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224 results on '"Artini, Paolo Giovanni"'

6. Acyl-Carnitines Exert Positive Effects on Mitochondrial Activity under Oxidative Stress in Mouse Oocytes: A Potential Mechanism Underlying Carnitine Efficacy on PCOS

Author

Placidi, Martina, primary, Vergara, Teresa, additional, Casoli, Giovanni, additional, Flati, Irene, additional, Capece, Daria, additional, Artini, Paolo Giovanni, additional, Virmani, Ashraf, additional, Zanatta, Samuele, additional, D’Alessandro, Anna Maria, additional, Tatone, Carla, additional, and Di Emidio, Giovanna, additional

Published
2023
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16. Endometrial Dysbiosis Is Related to Inflammatory Factors in Women with Repeated Implantation Failure: A Pilot Study

Author

Cela, Vito, primary, Daniele, Simona, additional, Obino, Maria Elena Rosa, additional, Ruggiero, Maria, additional, Zappelli, Elisa, additional, Ceccarelli, Lorenzo, additional, Papini, Francesca, additional, Marzi, Ilaria, additional, Scarfò, Giorgia, additional, Tosi, Fulvia, additional, Franzoni, Ferdinando, additional, Martini, Claudia, additional, and Artini, Paolo Giovanni, additional

Published
2022
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18. Gene expression profiles of cumulus cells obtained from women treated with recombinant human luteinizing hormone + recombinant human follicle-stimulating hormone or highly purified human menopausal gonadotropin versus recombinant human follicle-stimulating hormone alone

Author

Gatta, Valentina, Tatone, Carla, Ciriminna, Rosanna, Vento, Marilena, Franchi, Sara, d'Aurora, Marco, Sperduti, Samantha, Cela, Vito, Borzì, Placido, Palermo, Roberto, Stuppia, Liborio, and Artini, Paolo Giovanni

Published
2013
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21. Oxidative Stress Measurement in Frozen/Thawed Human Sperm: The Protective Role of an In Vitro Treatment with Myo-Inositol

Author

Ponchia, Rosetta, primary, Bruno, Annunziata, additional, Renzi, Asia, additional, Landi, Claudia, additional, Shaba, Enxhi, additional, Luongo, Francesca Paola, additional, Haxhiu, Alesandro, additional, Artini, Paolo Giovanni, additional, Luddi, Alice, additional, Governini, Laura, additional, and Piomboni, Paola, additional

Published
2021
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23. Exploring Epithelial–Mesenchymal Transition Signals in Endometriosis Diagnosis and In Vitro Fertilization Outcomes

Author

Cela, Vito, primary, Malacarne, Elisa, additional, Obino, Maria Elena Rosa, additional, Marzi, Ilaria, additional, Papini, Francesca, additional, Vergine, Francesca, additional, Pisacreta, Elena, additional, Zappelli, Elisa, additional, Pietrobono, Deborah, additional, Scarfò, Giorgia, additional, Daniele, Simona, additional, Franzoni, Ferdinando, additional, Martini, Claudia, additional, and Artini, Paolo Giovanni, additional

Published
2021
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24. Mitochondrial Sirtuins in Reproduction

Author

Di Emidio, Giovanna, primary, Falone, Stefano, additional, Artini, Paolo Giovanni, additional, Amicarelli, Fernanda, additional, D’Alessandro, Anna Maria, additional, and Tatone, Carla, additional

Published
2021
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31. Regulatory Functions of L-Carnitine, Acetyl, and Propionyl L-Carnitine in a PCOS Mouse Model: Focus on Antioxidant/Antiglycative Molecular Pathways in the Ovarian Microenvironment

Author

Di Emidio, Giovanna, primary, Rea, Francesco, additional, Placidi, Martina, additional, Rossi, Giulia, additional, Cocciolone, Domenica, additional, Virmani, Ashraf, additional, Macchiarelli, Guido, additional, Palmerini, Maria Grazia, additional, D’Alessandro, Anna Maria, additional, Artini, Paolo Giovanni, additional, and Tatone, Carla, additional

Published
2020
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38. Premature ovarian insufficiency: current progress and future prospectives

Author

Pinelli, Sara, Simi, Giovanna, Obino, MARIA ELENA ROSA, Cela, Vito, and Artini, PAOLO GIOVANNI

Subjects
ovarian aging, premature ovarian insufficiency, ovarian aging, premature ovarian failure, POF, POI, early menopause, premature ovarian insufficiency, early menopause, POI, POF, premature ovarian failure
Published
2017

42. Peroxisome Proliferator-Activated Receptors in Female Reproduction and Fertility

Author

Vitti, Maurizio, Di Emidio, Giovanna, Di Carlo, Michela, Carta, Gaspare, Antonosante, Andrea, Artini, Paolo Giovanni, Cimini, Annamaria, Tatone, Carla, and Benedetti, Elisabetta

Subjects
Article Subject
Abstract

Reproductive functions may be altered by the exposure to a multitude of endogenous and exogenous agents, drug or environmental pollutants, which are known to affect gene transcription through the peroxisome proliferator-activated receptors (PPARs) activation. PPARs act as ligand activated transcription factors and regulate metabolic processes such as lipid and glucose metabolism, energy homeostasis, inflammation, and cell proliferation and differentiation. All PPARs isotypes are expressed along the hypothalamic-pituitary-gonadal axis and are strictly involved in reproductive functions. Since female fertility and energy metabolism are tightly interconnected, the research on female infertility points towards the exploration of potential PPARs activating/antagonizing compounds, mainly belonging to the class of thiazolidinediones (TZDs) and fibrates, as useful agents for the maintenance of metabolic homeostasis in women with ovarian dysfunctions. In the present review, we discuss the recent evidence about PPARs expression in the hypothalamic-pituitary-gonadal axis and their involvement in female reproduction. Finally, the therapeutic potential of their manipulation through several drugs is also discussed.

Published
2016
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44. The Natural Carotenoid Crocetin and the Synthetic Tellurium Compound AS101 Protect the Ovary against Cyclophosphamide by Modulating SIRT1 and Mitochondrial Markers

Author

Di Emidio, Giovanna, primary, Rossi, Giulia, additional, Bonomo, Isabelle, additional, Alonso, Gonzalo Luis, additional, Sferra, Roberta, additional, Vetuschi, Antonella, additional, Artini, Paolo Giovanni, additional, Provenzani, Alessandro, additional, Falone, Stefano, additional, Carta, Gaspare, additional, D’Alessandro, Anna Maria, additional, Amicarelli, Fernanda, additional, and Tatone, Carla, additional

Published
2017
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45. Modulating Intrafollicular Hormonal Milieu in Controlled Ovarian Stimulation: Insights From PPAR Expression in Human Granulosa Cells

Author

Tatone, Carla, Benedetti, Elisabetta, Vitti, Maurizio, Di Emidio, Giovanna, Ciriminna, Rosanna, Vento, Maria Elena, Cela, Vito, Borzì, Placido, Carta, Gaspare, Lispi, Monica, Cimini, Anna Maria, and Artini, PAOLO GIOVANNI

Subjects
Granulosa Cells, Physiology, Clinical Biochemistry, Peroxisome Proliferator-Activated Receptors, Intracellular Space, Cell Biology, Luteinizing Hormone, Hormones, Recombinant Proteins, Protein Transport, Aromatase, Retinoid X Receptors, Ovarian Follicle, Ovulation Induction, Humans, Female, Steroids, Acyl Coenzyme A, Follicle Stimulating Hormone
Abstract

Controlled ovarian stimulation (COS) leading to ovulation of multiple follicles is a crucial aspect of biomedical infertility care. Nevertheless, biomarkers useful for COS management are still lacking. Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors relevant to steroid metabolism in granulosa cells (GCs). We investigated whether PPARs and their steroidogenic targets were differentially expressed in GCs differentiated under different recombinant or urinary gonadotropin preparations. GCs from women subjected to COS with r-hFSH, r-hFSH/r-hLH, or hMG-HP were processed to assess expression of PPARα, PPARβ/δ, PPARγ, and steroidogenic enzymes under PPAR modulation. As an evidence of their activation, all PPAR isotypes with their coactivators, the retinoic-X-receptors (RXRs), localized in the nucleus. When GCs from r-hFSH/r-hLH group were compared with r-hFSH, a significant reduction of PPARα protein was observed. By contrast, an increase of PPARβ/δ at both protein and mRNA levels along with that of PPARγ protein were detected. The steroidogenic enzymes 17βHSD IV, 3βHSD II, and HMG-CoA red were downregulated in the r-hFSH/r-hLH group in comparison to r-hFSH unlike CYP19A1 that remained unchanged. In GCs from urinary FSH-LH stimulation (hMG-HP), PPARα was more expressed in comparison with r-hFSH/r-hLH group. Likewise, 3βHSD II and 17βHSD IV were increased suggesting that hMG-HP partially mimicked r-hFSH/r-hLH effects. In summary, transcript analysis associated to protein investigation revealed differential effects of COS protocols on PPARs and their steroidogenic targets in relation to LH and gonadotropin source. These observations candidate PPARs as new biomarkers of follicle competence opening new hypotheses on COS effects on ovarian physiology. J. Cell. Physiol. 231: 908-914, 2016. © 2015 Wiley Periodicals, Inc.

Published
2015

46. Inside the granulosa transcriptome

Author

D’Aurora, Marco, primary, Sperduti, Samantha, additional, Di Emidio, Giovanna, additional, Stuppia, Liborio, additional, Artini, Paolo Giovanni, additional, and Gatta, Valentina, additional

Published
2016
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49. Ovarian response to controlled ovarian stimulation in women with different polycystic ovary syndrome phenotypes.

Author

Cela, Vito, Obino, Maria Elena Rosa, Alberga, Ylenia, Pinelli, Sara, Sergiampietri, Claudia, Casarosa, Elena, Simi, Giovanna, Papini, Francesca, and Artini, Paolo Giovanni

Subjects
INDUCED ovulation, POLYCYSTIC ovary syndrome, OVARIAN hyperstimulation syndrome, LUTEINIZING hormone releasing hormone, INFERTILITY
Abstract

Controlled ovarian stimulation (COH) in PCOS is a challenge for fertility expert both ovarian hyperstimulation syndrome (OHSS) and oocytes immaturity are the two major complication. Ovarian response to COH vary widely among POCS patients and while some patients are more likely to show resistance to COH, other experienced an exaggerated response. The aim of our study is to investigate a possible correlation between PCOS phenotypes and the variety of ovarian response to COH and ART outcomes in patients with different PCOS phenotypes. We retrospectively analyzed a total of 71 cycles performed in 44 PCOS infertile patients attending ART at Centre of Infertility and Assisted Reproduction of Pisa University between January 2013 and January 2016. Patientsundergoing IVF with GnRH-antagonist protocol and 150-225 UI/days of recombinant FSH; triggering was carried out using 250 mg of recombinant hCG or a GnRH analogous on the basis of the risk to OHSS. We observed that Phenotype B had a tendency to have a greater doses of gonadotropins used respect to all phenotypes. Phenotype A group showed a greater serum estrogen levels compared to all phenotypes groups, a greater number of follicles of diameter between 8-12 mm found by ultrasound on the day of triggering and a greater mean number of freeze embryo. Additionally serum AMH and antral follicles count (AFC) follow the same trend in the different phenotypes ad they were significantly higher in phenotype A and in phenotype D. In conclusion this study shows that the features of PCOS phenotypes reflect the variety of ovarian response to COH as well as the risks to develop OHSS. Serum AMH and AFC are related to the degree of ovulatory dysfunction making these ‘added values’ in identifying the different PCOS phenotypes. Phenotype A seems to be the phenotype with the higher risk to develop OHSS and the use of GnRH as a trigger seems to improve oocyte quality. To classify PCOS phenotype at diagnosis might help clinicians to identify patients at greater risk of OHSS, customize therapy and subsequently plan the trigger agent. [ABSTRACT FROM AUTHOR]

Published
2018
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