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3 results on '"Articular impairment"'

1. Arthropathy in acromegaly: a questionnaire-based estimation of motor disability and its relation with quality of life and work productivity.

Author

Fatti, L. M., Cangiano, B., Vitale, G., Persani, L., Mantovani, G., Sala, E., Arosio, M., Maffei, P., Dassie, F., Mormando, M., Giampietro, A., Tanda, L., Masiello, E. R., Nazzari, E., Ferone, D., Corbetta, S., Passeri, E., Guaraldi, F., Grottoli, S., and Cannavò, S.

Abstract

Purpose: Arthropathy is a common and disabling complication of acromegaly. Since in this condition radiological findings rarely correspond to functional impairment, we elected to quantify in a large cohort of acromegalic patients: the degree of motor disability compared with data from general population, the impact of joint involvement on quality of life and work productivity, and to look for associated factors. Methods: In 211 acromegalic patients, 131 with controlled disease and 80 with active disease, eight validated scales were used to evaluate the (i) prevalence and distribution of arthropathy, (ii) degree of motor disability and joint symptoms (VAS, AIMS symptoms and WOMAC), (iii) quality of life (AcroQoL and PASQ) and work capability (WPAI:GH) as consequences of joint complications. Results: Using the WOMAC questionnaire, for which population based normative values are available, a significantly higher prevalence and severity of motor disability was detected in acromegalics compared to the general population from literature. The results provided by the different questionnaires turned out to be highly concordant. All measures of motor disability correlated both with impaired quality of life and motor disability and were worse in females and in patients with higher BMI. Conclusions: The questionnaires VAS, AIMS symptoms, and WOMAC (this latter both as a whole and with its functionality subscale), with their scores, proved to be the most adequate tools to evaluate motor disability and its consequences on both quality of life and work productivity in acromegaly. Female gender and higher BMI are associated with worse articular symptoms. [ABSTRACT FROM AUTHOR]

Published
2019
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2. Arthropathy in acromegaly: a questionnaire-based estimation of motor disability and its relation with quality of life and work productivity

Author

M. L. Torre, Massimo Scacchi, Luca Persani, S. Cannavò, Davide Soranna, Biagio Cangiano, Elena Nazzari, Pietro Maffei, Elena Passeri, Maura Arosio, F. Cavagnini, Sabrina Corbetta, Diego Ferone, Elisa Sala, Letizia Maria Fatti, Francesca Dassie, Giovanni Vitale, Giovanna Mantovani, Silvia Grottoli, Federica Guaraldi, E. R. Masiello, Marilda Mormando, Antonella Giampietro, Antonella Zambon, L. Tanda, Fatti, L, Cangiano, B, Vitale, G, Persani, L, Mantovani, G, Sala, E, Arosio, M, Maffei, P, Dassie, F, Mormando, M, Giampietro, A, Tanda, L, Masiello, E, Nazzari, E, Ferone, D, Corbetta, S, Passeri, E, Guaraldi, F, Grottoli, S, Cannavo, S, Torre, M, Soranna, D, Zambon, A, Cavagnini, F, and Scacchi, M

Subjects
Adult, Male, medicine.medical_specialty, WOMAC, Cross-sectional study, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, 030209 endocrinology & metabolism, Osteoarthritis, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, Quality of life, Surveys and Questionnaires, Arthropathy, Acromegaly, Articular impairment, Complication, Gender, Rehabilitation, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Joint Diseases, Middle Aged, Quality of Life, Acromegaly, Articular impairment, Complication, Gender, Osteoarthritis, Rehabilitation, medicine, 80 and over, Young adult, education, education.field_of_study, business.industry, medicine.disease, Diabetes and Metabolism, Physical therapy, Osteoarthriti, business, 030217 neurology & neurosurgery
Abstract

Purpose: Arthropathy is a common and disabling complication of acromegaly. Since in this condition radiological findings rarely correspond to functional impairment, we elected to quantify in a large cohort of acromegalic patients: the degree of motor disability compared with data from general population, the impact of joint involvement on quality of life and work productivity, and to look for associated factors. Methods: In 211 acromegalic patients, 131 with controlled disease and 80 with active disease, eight validated scales were used to evaluate the (i) prevalence and distribution of arthropathy, (ii) degree of motor disability and joint symptoms (VAS, AIMS symptoms and WOMAC), (iii) quality of life (AcroQoL and PASQ) and work capability (WPAI:GH) as consequences of joint complications. Results: Using the WOMAC questionnaire, for which population based normative values are available, a significantly higher prevalence and severity of motor disability was detected in acromegalics compared to the general population from literature. The results provided by the different questionnaires turned out to be highly concordant. All measures of motor disability correlated both with impaired quality of life and motor disability and were worse in females and in patients with higher BMI. Conclusions: The questionnaires VAS, AIMS symptoms, and WOMAC (this latter both as a whole and with its functionality subscale), with their scores, proved to be the most adequate tools to evaluate motor disability and its consequences on both quality of life and work productivity in acromegaly. Female gender and higher BMI are associated with worse articular symptoms.

Published
2019

3. Arthropathy in acromegaly: a questionnaire-based estimation of motor disability and its relation with quality of life and work productivity

Author

Fatti, L, Cangiano, B, Vitale, G, Persani, L, Mantovani, G, Sala, E, Arosio, M, Maffei, P, Dassie, F, Mormando, M, Giampietro, A, Tanda, L, Masiello, E, Nazzari, E, Ferone, D, Corbetta, S, Passeri, E, Guaraldi, F, Grottoli, S, Cannavo, S, Torre, M, Soranna, D, Zambon, A, Cavagnini, F, Scacchi, M, Fatti L. M., Cangiano B., Vitale G., Persani L., Mantovani G., Sala E., Arosio M., Maffei P., Dassie F., Mormando M., Giampietro A., Tanda L., Masiello E. R., Nazzari E., Ferone D., Corbetta S., Passeri E., Guaraldi F., Grottoli S., Cannavo S., Torre M. L. T., Soranna D., Zambon A., Cavagnini F., Scacchi M., Fatti, L, Cangiano, B, Vitale, G, Persani, L, Mantovani, G, Sala, E, Arosio, M, Maffei, P, Dassie, F, Mormando, M, Giampietro, A, Tanda, L, Masiello, E, Nazzari, E, Ferone, D, Corbetta, S, Passeri, E, Guaraldi, F, Grottoli, S, Cannavo, S, Torre, M, Soranna, D, Zambon, A, Cavagnini, F, Scacchi, M, Fatti L. M., Cangiano B., Vitale G., Persani L., Mantovani G., Sala E., Arosio M., Maffei P., Dassie F., Mormando M., Giampietro A., Tanda L., Masiello E. R., Nazzari E., Ferone D., Corbetta S., Passeri E., Guaraldi F., Grottoli S., Cannavo S., Torre M. L. T., Soranna D., Zambon A., Cavagnini F., and Scacchi M.

Abstract

Purpose: Arthropathy is a common and disabling complication of acromegaly. Since in this condition radiological findings rarely correspond to functional impairment, we elected to quantify in a large cohort of acromegalic patients: the degree of motor disability compared with data from general population, the impact of joint involvement on quality of life and work productivity, and to look for associated factors. Methods: In 211 acromegalic patients, 131 with controlled disease and 80 with active disease, eight validated scales were used to evaluate the (i) prevalence and distribution of arthropathy, (ii) degree of motor disability and joint symptoms (VAS, AIMS symptoms and WOMAC), (iii) quality of life (AcroQoL and PASQ) and work capability (WPAI:GH) as consequences of joint complications. Results: Using the WOMAC questionnaire, for which population based normative values are available, a significantly higher prevalence and severity of motor disability was detected in acromegalics compared to the general population from literature. The results provided by the different questionnaires turned out to be highly concordant. All measures of motor disability correlated both with impaired quality of life and motor disability and were worse in females and in patients with higher BMI. Conclusions: The questionnaires VAS, AIMS symptoms, and WOMAC (this latter both as a whole and with its functionality subscale), with their scores, proved to be the most adequate tools to evaluate motor disability and its consequences on both quality of life and work productivity in acromegaly. Female gender and higher BMI are associated with worse articular symptoms.

Published
2019

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