Search

Your search keyword '"Arsenijevic, V.A."' showing total 4 results
Start Over Author "Arsenijevic, V.A."
4 results on '"Arsenijevic, V.A."'

2. Etiology and Outcome of Candidemia in Neonates and Children in Europe: An 11-year Multinational Retrospective Study

Author

Warris, A., Pana, Z.D., Oletto, A., Lundin, R., Castagnola, E., Lehrnbecher, T., Groll, A.H., Roilides, E., Andersen, C.T., Arendrup, M.C., Arsenijevic, V.A., Bianchini, S., Both, U. von, Chmelnik, M., Controzzi, T., Emonts, M., Esposito, S., Ferreras-Antolin, L., Henriet, S.S., Iosifidis, E., Irwin, A., Kopsidas, J., Lagrou, K., Lyall, H., Casteleiro, A.M., Mesini, A., Olbrich, P., Paulus, S., Lausch, K.R., Soler-Palacin, P., Spyridis, N., Strenger, V., Theodoraki, M., and Wolfs, T.

Subjects
Microbiology (medical), medicine.medical_specialty, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Candida parapsilosis, 03 medical and health sciences, [**EUROCANDY study group], 0302 clinical medicine, children, 030225 pediatrics, Internal medicine, Epidemiology, medicine, 030212 general & internal medicine, Candida albicans, Candida spp, biology, infants, business.industry, candidemia, Postmenstrual Age, Retrospective cohort study, Odds ratio, biology.organism_classification, neonates, Confidence interval, Infectious Diseases, EUROCANDY Study Group, Pediatrics, Perinatology and Child Health, Etiology, business
Abstract

BACKGROUND: Data on Candida bloodstream infections in pediatric patients in Europe are limited. We performed a retrospective multicenter European study of the epidemiology and outcome of neonatal and pediatric candidemia. MATERIAL AND METHODS: All first positive blood cultures from patients ≤ 18 years of age with candidemia were registered. Patients' demographic and clinical characteristics and causative Candida species were collected and analyzed. Regression analysis was used to identify factors independently associated with mortality. RESULTS: One thousand three hundred ninety-five episodes of candidemia (57.8% male) were reported from 23 hospitals in 10 European countries. Of the 1395 episodes, 36.4% occurred in neonates (≤ 44 weeks postmenstrual age), 13.8% in infants (> 44 weeks postmenstrual age to 1 year) and 49.8% in children and adolescents. Candida albicans (52.5%) and Candida parapsilosis (28%) were the predominant species. A higher proportion of candidemia caused by C. albicans was observed among neonatal patients (60.2%) with highest rates of C. parapsilosis seen among infants (42%). Children admitted to hematology-oncology wards presented the highest rates of non-albicans Candida species. Candidemia because of C. albicans was more frequent than non-albicans Candida in Northern versus Southern Europe (odds ratio, 2.3; 95% confidence interval, 1.8-2.9; P < 0.001). The all-cause mortality at 30 days was 14.4%. All-cause mortality was higher among patients admitted to the neonatal or pediatric intensive care units than other wards. Over time, no significant changes in species distribution were observed. CONCLUSIONS: This first multicenter European study shows unique characteristics of the epidemiology of pediatric candidemia. The insights obtained from this study will be useful to guide clinical management and antifungal stewardship. ispartof: Pediatr Infect Dis J vol:39 issue:2 pages:114-120 ispartof: location:United States status: published

Published
2020
Full Text
View/download PDF

3. Importance of Resolving Fungal Nomenclature: the Case of Multiple Pathogenic Species in the Cryptococcus Genus

Author

Hagen, F., Lumbsch, H.T., Arsenijevic, V.A., Badali, H., Bertout, S., Billmyre, R.B., Bragulat, M.R., Cabanes, F.J., Carbia, M., Chakrabarti, A, Chaturvedi, S., Chaturvedi, V., Chen, M., Chowdhary, A., Colom, M.F., Cornely, O.A., Crous, P.W., Cuetara, M.S., Diaz, M.R., Espinel-Ingroff, A., Fakhim, H., Falk, R., Fang, W., Herkert, P.F., Rodriguez, C., Fraser, J.A., Gene, J., Guarro, J., Idnurm, A., Illnait-Zaragozi, M.T., Khan, Z., Khayhan, K., Kolecka, A., Kurtzman, C.P., Lagrou, K., Liao, W., Linares, C., Meis, J.F.G.M., Nielsen, K., Nyazika, T.K., Pan, W., Pekmezovic, M., Polacheck, I., Posteraro, B., Queiroz Telles, F.F. de, Romeo, O., Sanchez, M., Sampaio, A., Sanguinetti, M., Sriburee, P., Sugita, T., Taj-Aldeen, S.J., Takashima, M., Taylor, J.W., Theelen, B., Tomazin, R., Verweij, P.E., Wahyuningsih, R., Wang, P., Boekhout, T., Hagen, F., Lumbsch, H.T., Arsenijevic, V.A., Badali, H., Bertout, S., Billmyre, R.B., Bragulat, M.R., Cabanes, F.J., Carbia, M., Chakrabarti, A, Chaturvedi, S., Chaturvedi, V., Chen, M., Chowdhary, A., Colom, M.F., Cornely, O.A., Crous, P.W., Cuetara, M.S., Diaz, M.R., Espinel-Ingroff, A., Fakhim, H., Falk, R., Fang, W., Herkert, P.F., Rodriguez, C., Fraser, J.A., Gene, J., Guarro, J., Idnurm, A., Illnait-Zaragozi, M.T., Khan, Z., Khayhan, K., Kolecka, A., Kurtzman, C.P., Lagrou, K., Liao, W., Linares, C., Meis, J.F.G.M., Nielsen, K., Nyazika, T.K., Pan, W., Pekmezovic, M., Polacheck, I., Posteraro, B., Queiroz Telles, F.F. de, Romeo, O., Sanchez, M., Sampaio, A., Sanguinetti, M., Sriburee, P., Sugita, T., Taj-Aldeen, S.J., Takashima, M., Taylor, J.W., Theelen, B., Tomazin, R., Verweij, P.E., Wahyuningsih, R., Wang, P., and Boekhout, T.

Abstract

Contains fulltext : 177602.pdf (publisher's version ) (Open Access), Cryptococcosis is a major fungal disease caused by members of the Cryptococcus gattii and Cryptococcus neoformans species complexes. After more than 15 years of molecular genetic and phenotypic studies and much debate, a proposal for a taxonomic revision was made. The two varieties within C. neoformans were raised to species level, and the same was done for five genotypes within C. gattii. In a recent perspective (K. J. Kwon-Chung et al., mSphere 2:e00357-16, 2017, https://doi.org/10.1128/mSphere.00357-16), it was argued that this taxonomic proposal was premature and without consensus in the community. Although the authors of the perspective recognized the existence of genetic diversity, they preferred the use of the informal nomenclature "C. neoformans species complex" and "C. gattii species complex." Here we highlight the advantage of recognizing these seven species, as ignoring these species will impede deciphering further biologically and clinically relevant differences between them, which may in turn delay future clinical advances.

Published
2017

Catalog

Books, media, physical & digital resources
See catalog results