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Using the SCI-expanded database, this study provides a quantitative description of the development of the research involving matrix metalloproteinase (MMP) over a period of 20 years. From 1986 to 2007 the scientific literature related to MMP increased sevenfold (397 papers in 1986-1987 and 2834 in 2006-2007). The number of countries participating in MMP-related research doubled during this period (33 in 1986-1987 to 67 in 2006-2007), and the USA continually remained the leader. Several industrialized nations (Japan, Germany, UK, Canada, and France) also continuously played important roles, with some emerging Asian countries joining the top 10 most productive countries in 20062007: China (ranked 5th), South Korea (6th), and Taiwan (10th). The MMP-related literature was distributed among a continuously growing number of journals (188 in 1986-1987, 527 in 1996-1997, and 913 in 2006-2007) and The Journal of Biological Chemistry remained the most prolific throughout the entire period. The development of the research involving MMPs during the past two decades was also characterized by a progressive transfer of interest from basic research to clinical medicine; cell biology and pharmacology were important routes of investigation generally pursued by researchers. Journals dedicated to oncology have progressively risen to the top 8 most prolific journals during the 20 year period analyzed. Key words: matrix metalloproteinase, MMP, journal analysis, cancer research, bibliometrics. Menee sur la base de donneees SCI-expanded, cette etude presente une description quantitative du deeveloppement de la recherche sur les metalloproteiases matricielles sur une peeriode de 20 ans. De 1986 a 2007, la litterature scientifique en lien avec les MMP s'est accrue d'un facteur 7 (397 articles en 1986-1987 a 2834 en 2006-2007). Durant la periode 1986-2007, le nombre de pays participant a la recherche sur les MMP a double (33 en 1986-1987 et 67 en 2006-2007), et les Etats-Unis ont maintenu leur position de leader. Plusieurs pays industrialises (Japon, Allemagne, RoyaumeUni, Canada et France) ont aussi joue un role important, avec quelques pays emergents d'Asie qui se sont joint aux dix pays les plus productifs en 2006-2007 : la Chine (5ieme rang), la Coree du Sud (6ieme) et Taiwan (10ieme). La litterature reliee aux MMP etait distribueeea travers un nombre croissant de revues scientifiques (188 en 1986-1987, 527 en 19961997 et 913 en 2006-2007), et The Journal of Biological Chemistry est demeuree la plus prolifique durant toute cette periode. Le developpement de la recherche sur les MMP au cours des deux dernieres deecennies a aussi ete caracteerise par un transfert progressif de l'interet de la recherche fondamentale vers la medecine clinique ; la biologie cellulaire et la pharmacologie ont constitue; des voies de recherche importantes geneeralement poursuivies par les chercheurs. Au cours de la periode analysee, des revues specialiseees dans la recherche en oncologie ont progressivement integre le top-8 des revues les plus prolifiques. Mots-cles: metalloproteases matricielles, MMP, analyse des revues scientifiques, recherche sur le cancer, bibliomeetrie. [Traduit par la Redaction], Introduction Among the various types of proteinases involved in extracellular matrix degradation, a predominant group is the matrix metalloproteinases (MMPs) or matrixins. MMPs were described in a seminal study in [...]

Aims: To provide a snapshot of the scientific literature on orofacial pain. Methods: The authors identified 975 papers related to orofacial pain in the Current Contents Life Sciences and Clinical Medicine collections of the Thomson Scientific database that were published during 2004 and 2005 and analyzed them using bibliometric indicators. Results: Among the 54 countries involved, the United States ranks first by number of papers (293), followed by Japan (107), and the United Kingdom (90). The high volume of research activity in some Northern European countries is highlighted, along with that of the European Union (384 papers). The scientific literature on orofacial pain was published in 247 journals; 13 of the top 15 most prolific journals for articles on orofacial pain were found in the Dentistry, Oral Surgery and Medicine subdiscipline of Current Contents/Clinical Medicine, and the Journal of Orofacial Pain was the highest ranked for such articles. Conclusion: This study complements subject reviews of orofacial pain research and provides a more complete picture of the research activity in this field. [ABSTRACT FROM AUTHOR]

Purpose Obstructive sleep apnea (OSA) has been described as a common sleep respiratory disorder. Its prevalence in the adult population has been reported to be high, varying from 3% to 28%. Dental practitioners play a key role in the treatment of this disease, using tailor-made mandibular advancement devices (MADs). This pilot study assessed the efficacy and compliance of a custom-fitted thermoplastic MAD for the treatment of moderate to severe OSA syndrome. Materials and Methods In this open study without a control group, OSA syndrome sufferers were enrolled by four centers. One specific MAD was custom fitted to the patients. Polysomnography, Epworth, and snoring scales were administered from inclusion to 45 days postinclusion. Results The study population consisted of 33 men and 8 women; 35 patients completed the study. Patient response was high with 69% of them considered as responders, and 60% showing a complete response. Also, 77.3% of patients with moderate OSA syndrome presented a complete response. An improvement was observed in the apnea hypopnea index, which decreased from 34.1 ± 18.9 to 12.8 ± 14.1. The Epworth Sleepiness Scale score, snoring, and quality of sleep scores decreased with the device ( p < 0.0001). Compliance rates were high, with patients wearing the device 6.5 nights a week. Side effects and patient complaints were minor and transient. Conclusion This custom-fitted MAD improved respiratory and somnolence parameters, with response rates similar to those published in the literature with other devices. [ABSTRACT FROM AUTHOR]

While functional imaging and deep brain stimulation studies point to a pivotal role of the hypothalamus in the pathophysiology of migraine and trigeminal autonomic cephalalgias, the circuitry and the mechanisms underlying the modulation of medullary trigeminovascular (Sp5C) neu-rons have not been fully identified. We investigated the existence of a direct anatomo-functional relationship between hypothalamic excitability disturbances and modifications of the activities of Sp5C neurons in the rat. Anterograde and retrograde neuronal anatomical tracing, intrahy-pothalamic microinjections, extracellular single-unit recordings of Sp5C neurons, and behavioral trials were used in this study. We found that neurons of the paraventricular nucleus of the hypothalamus (P VN) send descending projections to the superior salivatory nucleus, a region that gives rise to parasympathetic outflow to cephalic and ocular/nasal structures. PVN cells project also to laminae I and outer II of the Sp5C. Microinjections of the GABAa agonist muscimol into PVN inhibit both basal and meningeal-evoked activities of Sp5C neurons. Such inhibitions were reduced in acutely restrained stressed rats. GABAa antagonist gabazine infusions into the PVN facilitate meningeal-evoked responses of Sp5C neurons. PVN injections of the neuropeptide pituitary adenylate cyclase activating peptide (PACAP38) enhance Sp5C basal activities, whereas the antagonist PACAP6-38 depresses all types of Sp5C activities. 5-HT1B/D receptor agonist naratriptan infusion confined to the PVN depresses both basal and meningeal-evoked Sp5C activities. Our findings suggest that paraventricular hypothalamic neurons directly control both spontaneous and evoked activities of Sp5C neurons and could act either as modulators or triggers of migraine and/or trigeminal autonomic cephalalgias by integrating nociceptive, autonomic, and stress processing mechanisms. [ABSTRACT FROM AUTHOR]

Aim This study charts the growth of the scientific journal literature on headache for 30+ years (1983-2014). Methods Using the Web of Science, articles published in four two-year periods (1983-1984, 1993-1994, 2003-2004, 2013-2014) from journals indexed in the Science Citation Index Expanded database were retrieved and analyzed. Results From 1983-1984 to 2013-2014, the scientific literature on headache increased nearly fourfold (3.8) from 468 to 1776 articles; the number of participating countries more than doubled (26 to 67); and the two most prolific countries in each period were the USA and Italy. While several European countries (Italy, Germany, UK and Denmark) were among the top 10 in each period, the notable appearance of Turkey, China and Brazil among the top 10 in 2013-2014 indicates the growing geographic spread of publications on headache research. Meanwhile, the comet-like distribution of journals has not changed: two journals, Headache and Cephalalgia, persist throughout as the nucleus, with the tail increasing more than threefold from 141 journals in 1983-1984 to 462 in 2013-2014. Conclusion Our study follows the recent growth and spread of the scientific literature on headache research and should stimulate further bibliometric investigation in this field. [ABSTRACT FROM AUTHOR]