Search

Your search keyword '"Arpa, Abdurrahman"' showing total 10 results
Start Over Author "Arpa, Abdurrahman"
10 results on '"Arpa, Abdurrahman"'

6. Histopathological effects of nimodipine and pentoxifylline on the vessel wall in end-toend anastomoses in rat carotid arteries.

Author

ARPA, Abdurrahman and AYDIN OZTURK, Pınar

Subjects
*CAROTID artery, *PENTOXIFYLLINE, *CEREBRAL vasospasm, *NIMODIPINE, *HISTOPATHOLOGY, *SPRAGUE Dawley rats
Abstract

When reperfusion following ischemia occurs, oxygen returns to the ischemic tissue, increasing free oxygen radicals and inducing paradox secondary damage. Before infarction, revascularization may influence the morbidity rate. Successful revascularization is not always achieved due to stenosis incidence, proliferation of smooth muscle cells, and intimal hyperplasia. This study compares the effects of nimodipine that prevents vasospasm and pentoxifylline, which stimulates growth factors and reduces collagen synthesis on intimal hyperplasia. Eighteen randomly selected Sprague-Dawley rats were divided into three groups: Group 1, the control group; Group 2, intraperitoneally administered nimodipine; Group 3, orally administered pentoxifylline. Their right-sided carotid arteries were used for anastomosis and the left-sided ones for the control. After a 7-day treatment, both the right and left carotid arteries were removed. In the biopsy, the lumen's area and diameter, thickness of tunica media thickness, thrombus, edema, intimal hyperplasia, vessel wall injury, and inflammation were analyzed. Pentoxifylline was effective in preventing intimal hyperplasia and tunica intima was similar to that in untreated carotid arteries. However, nimodipine inhibited intimal hyperplasia, but it was not as effective as pentoxifylline. The effects of pentoxifylline after anastomosis should be further assessed in vasoprotective treatment taking into account its efficacy against intimal hyperplasia. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

7. Küçük ve Dev Ensefalosellerin Etiyolojik Faktörler ve Peroperatif Süreç Açısından Karşılaştırılması.

Author

Aydın Öztürk, Pınar, Arpa, Abdurrahman, and Asena, Muhammet

Abstract

Objective: Encephaloceles are congenital neural tube defects and are characterized by the herniated of the brain and / or meninges through a defect in the skull. Cases where the encephalocele sac is larger than the head are called 'giant encephaloceles'. The management of 'giant encephaloceles' is quite different from small encephaloceles. In this study, small and 'giant encephaloceles' were compared in terms of etiological and peroperative management. Methods: The encephaloceles operated in the neonatal period in our hospital were divided into two groups according to their size and evaluated separately and comparatively. Results: 32 patients who were operated for encephalocele were included in the study. 62.5% of the patients are females and 37.5% are males. 15.6% of the patients had 'giant encephalocele'. 53.1% of the patients had neural tissue herniated into the sac. Extra-cranial anomaly was present in 21.9% of the patients. Ventricular dilatation requiring shunt insertion was found in 65.6% of the patients at birth or during a one-year follow-up period. Mean size of the sac was found to be 74.6 ± 110.3 cm2. Sac size as it increases, enhanced the risk of developing deficits (p = 0.023). Conclusion: Encephaloceles are a group of patients whose peroperative process should be managed well with a multidisciplinary approach. Although the postoperative process of "giant encephaloceles" is the same as other encephaloceles, careful preoperative preparation and coordinated work of the anesthesia and surgical team will reduce the risk of peroperative complications, which is higher than other encephaloceles. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

8. Rat karotid arterlerinde yapılan anastomozlarda nimodipin ve pentoksifilin maddelerinin damar duvarı üzerine histopatolojik etkilerinin araştırılması

Author

Arpa, Abdurrahman, Kemaloğlu, M. Serdar, Dicle Üniversitesi, Tıp Fakültesi, Rat karotid arterlerinde yapılan anastomozlarda nimodipin ve pentoksifilin maddelerinin damar duvarı üzerine histopatolojik etkilerinin araştırılması, Arpa, Abdurrahman, Kemaloğlu, Mustafa Serdar, and Beyin ve Sinir Cerrahisi Anabilim Dalı

Subjects
Hyperplasia, Restenosis, Vasopressins, Anastomosis, Nimodipin, Neurosurgery, Restenoz, Nöroşirürji, Intimal hyperplasia, Vazoprotective, Rats, Carotid arteries, Anastomoz, İntimal hiperplazi, Calcium channel blockers, Rat, Nimodipine, Pentoxifylline, Pentoksifilin, Vazoprotektif
Abstract

Rat karotid arterlerinde yapılan anastomozlarda nimodipin ve pentoksifilin maddelerinin damar duvarı üzerine histopatolojik etkilerinin araştırılması Abdurrahman ARPA, Dicle Üniversitesi Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, Diyarbakır.Giriş ve Amaç: Serebral iskemi, arteryel kan akımının azalmasına bağlı olarak serebral dokular için gerekli oksijenizasyonun sürdürülememesi durumudur. İskemi sonrasında oluşan reperfüzyon sonucunda, iskemik dokuya ulaşan oksijen, serbest oksijen radikallerini artırarak paradoks sekonder hasarlara neden olur. Bu nedenle enfarkt gelişmeden önce yapılacak revaskülarizasyon, morbiditenin derecesini etkileyebilmektedir. Revaskülarizasyon amacıyla yapılan girişimlerin başarısı stenoz oluşumu, düz kas hücre proliferasyonu ve intimal hiperplazi oluşumu nedeni ile beklenenden daha azdır. Vasküler rekonstruktif girişimlerden sonra gelişen bu hadiseler mortalite ve morbiditenin beklenenden daha yüksek olmasına sebep olmaktadır. Aynı zamanda geç dönemdeki daralma veya restenozda düz kas hücre migrasyonu, proliferasyonu ve ekstrasellüler matriks birikimi sonucu oluşan neointimal hiperplazi önemli rol oynamaktadır.Nimodipin, dihidropiridin türevi olan bir kalsiyum kanal blokörüdür. Pentoksifilin, ksantin türevi (teofilin benzeri) fosfodiesteraz inhibitörü bir ilaçtır. Rat karotis arterinde yapılan anastomozlarda nimodipin ve pentoksifilin maddelerinin damar duvarı üzerine histopatolojik etkilerini araştırdık.Gereç ve Yöntem: Çalışmamızda randomize olarak seçilen, 18 adet Sprague-Dawley tipi erkek veya dişi rat kullanıldı. Deney günü 4 saatlik açlık süresinden sonra ratlara 80mg/kg ketamin + 10 mg/kg ksilazin ile anestezi uygulandı.Anastomoz için sağ karotid arteri, kontrol için sol karotid arteri kullanıldı. Sterilizasyon sonrasında horizontal boyun insizyonu ile common karotid arter eksplore edildi. Karotid arter mikroklemple klemlenerek mikromakasla transekte edildi. 10/0 polipropilenle anastomoze edilerek dokular anatomik planda kapatıldı.Ratlar, 1 haftalık adaptasyon döneminden sonra rastgele seçilmiş üç gruba ayrıldı. Grup 1 ratlar kontrol grubu, grup 2 ratlar nimodipin 10mg/kg intraperitoneal günde tek doz 7 gün verilen grup, grup 3 ratlar pentoksifilin 100mg/kg oral günde tek doz 7 gün verilen grup olarak ayrıldı.Yedi günlük tedavi sonrasında anastomoz yapılan sağ karotid arteri ve yapılmayan sol karotid arteri 1 cm'lik segmentler halinde çıkarılarak patoloji laboratuvarına gönderildi. Alınan materyaller formol solusyonunda korunarak hematoksilen-eozin, PAS, masson ile boyanıp aynı patolog tarafından incelendi. İnflamasyon, damar duvar hasarı, intimal hiperplazi, lümen çapı, tunika media kalınlığı, trombüs, lümen alanı değerlendirildi. Bulgular: Anastomoz sonrasında kullanılan pentoksifilinin intimal hiperplaziyi azalttığı, lümen çap ve alanında belirgin küçülmeye sebep olmadığı görülmüştür. Nimodipin grubunun da aynı etkileri olduğu ancak pentoksifilin kadar etkin olmadığı görülmüştür.Sonuç: Pentoksifilin grubunun intimal hiperplaziyi önleme üzerine etkinliğinin belirgin olduğu ve ileri deneysel araştırmalar sonrasında tedavi protokollerinde yerinin olabileceği kanaati oluşmuştur.Anahtar Kelimeler: Rat, Anastomoz, İntimal hiperplazi, Restenoz, Nimodipin, Pentoksifilin, Vazoprotektif The comparison of histopathologic effects on vessel wall of pentoxifylline and nimodipine substances after anastomosis which made in the rat carotid arteries.Abdurrahman ARPA, Dicle University Faculty of Medicine, Department of Neurosurgery, Diyarbakır.Background and Objectives: Cerebral ischemia is unable to maintain the necessary conditions for the cerebral tissue oxygenation depending on the reduction of arterial blood flow. The results of reperfusion after ischemia occurring in oxygen reaching ischemic tissue, increasing reactive oxygen species can cause secondary damage. Therefore, revascularization before infarct development will be decreased the degree of morbidity. The success of the techniques of revascularization less than expected because of restenosis. These events developing after vascuar reconstructive procedures leads to higher than expected mortality and morbidity. At the same time in the late period smooth muscle cell migration, proliferation and extracellular matrix accumulation will be caused restenosis with intimal hyperplasia. Nimodipine is a dihydropyridine derivative calcium channel blocker. Pentoxifylline is a xanthine derivative phosphodiesterase inhibitör. Because of these we researched and compared histopathologic effects of nimodipine and pentoxifylline substances on vessel wall after anastomosis which made in the rat carotid arteries.Material and Method: In our work randomly chosen, Sprague-Dawley type, male or female 24 rats used. On the day of experiment, 80mg/kg ketamine + 10 mg/kg xylazine was given for anestesia, after 4 hour fasting. The rats right side carotid artery was used for anastomosis an the left side carotid artery was used for controlling. After sterilization the common carotid artery was explored by making a horizontal neck incision. Then the carotid artery was dissected and transected. Anastomosis was applied with 10/0 polypropylene suture.The rats were seperated into 3 groups. Group 1 rats were control group. Group 2 rats were nimodipine group which 10 mg/kg dose of nimodipine were given intraperitoneally through 7 days. Group 3 rats were pentoxifylline group which 100mg/kg dose of pentoxifylline were given oral through 7 days.After seven days treatment, the right carotid artery which were anastomosis and the left carotid artery which were not anastomosis were removed and sent to patology laboratory. The biopsies obtained were preserved in formalin solution, stained with hematoxylin-eosin, PAS, masson and examined by the same pathologist. Lumen diamater, lumen area, tunica media thickness, edema, vessel wall injury, intimal hyperplasia, thrombus and inflammation were evaluated.Results: Pentoksifilin used after anastomosis caused reduced intimal hyperplasia, but didn't decrease lumen diamater and area. The same effects as in the nimodipine group, but hasn't been shown to be effective as pentoxifylline.Conclusion: Effectiveness of pentoxifylline group is evident on the intimal hyperplasia prevention and it can be used treatment protocols after advanced experimental studies.Key words: Rat, Anastomosis, Intimal hyperplasia, Restenosis, Pentoxifylline, Nimodipine, Vazoprotective 97

Published
2016

10. Tavşanlarda Deneysel Subaraknoı̇d Kanama Modelı̇nde IV %20 Mannı̇tolün Serebral Vazospazm Üzerı̇ne Etkı̇lerı̇.

Author

Sanrı, Ömer, Yılmaz, Adil, Arpa, Abdurrahman, Öztürk, Pınar Aydın, and Turan, Yahya

Abstract

Objective: We found that the effects of 20% mannitol, which is frequently used in the treatment of subarachnoid hemorrhage (SAH), on cerebral vasospasm have not been investigated in the English literature. Therefore, in this study, we aimed to investigate the effects of intravenous 20% mannitol, an osmotic diuretic agent frequently used in the treatment of increased intracranial pressure syndrome (ICPPS), on cerebral vasospasm in an experimental SAH model in rabbits. Method: In our study, 28 New Zealand white rabbits were used. The rabbits were divided into 4 groups as Group 1 (control, n=7), Group 2 (SAH(+), n=7), Group 3 (SAH(-), 20% Mannitol(+), n=7), Group 4 (SAH(+), 20% Mannitol(+), n=7). Experimental SAH model SAH was induced by injecting autologous arterial blood into the cisterna magna of rabbits in Groups 2 and 4. Rabbits in groups 3 and 4 received 1 g/kg/day 20% mannitol intravenously for 3 days divided into 4 equal doses. All rabbits were sacrificed at the 72nd hour following SAH formation and the brain brainstem was removed globally and fixed. Sections obtained from the basilar arteries were stained with Hematoxylin and Eosin and examined under a microscope. Results: Vascular thickness, vessel diameter, lumen diameter, lumen cross-sectional area and total vessel area were measured in the basilar artery sections obtained. There was no significant difference between groups 1,3,4 in terms of vessel wall thickness (p=0.01). Among all groups, the highest vessel wall thickness was measured in group 2. There was no significant difference in basilar artery lumen diameter between groups 1 and 3 (p=0.46). No difference was found between the lumen diameters of groups 1,2,4. There was also no significant difference between basilar artery lumen cross-sectional areas (p=0.08). Conclusion: It was determined that 20% mannitol treatment had no positive or negative effect on cerebral vasospasm that developed after the experimental model of subarachnoid hemorrhage. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results