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2. Challenges associated with the implementation of institutional quarantine and isolation strategies during major multicountry viral outbreaks in Africa (2000–2023): a scoping review

Author

Jimoh Amzat, Ebunoluwa Oduwole, Saheed Akinmayowa Lawal, Olusola Aluko-Arowolo, Rotimi Afolabi, Isaac Akinkunmi Adedeji, Ige Angela Temisan, Ayoyinka Oludiran, Kafayat Aminu, Afeez Abolarinwa Salami, and Kehinde Kazeem Kanmodi

Subjects
Public aspects of medicine, RA1-1270
Abstract

Abstract Background Quarantine and isolation (Q&I) are interrelated but not mutually exclusive public health practices for disease control, which may face public resistance in the context of health emergencies due to associated challenges. Hence, it is often tough for most countries to implement Q&I even in the context of health emergencies. Therefore, this scoping review examines the challenges associated with the implementation of institutional Q&I strategies during major multicountry viral outbreaks (Ebola, Lassa and COVID-19) in Africa between 2000 and 2023. Methods This scoping review was designed based on Arksey and O’Malley’s guidelines. A systematic literature search, using nine online research databases, was conducted with the aid of relevant search terms, Boolean operators and truncations. All articles obtained from the literature search were electronically imported into Rayyan web application for deduplication based on specific inclusion and exclusion criteria. From the included literature, relevant data were charted, summarized, collated, and presented. Results This review included 24 of the 787 retrieved articles. Sixteen of the 24 selected articles investigated issues related to COVID-19 prevention and control in Africa. Two assessed precautionary practices for Lassa fever, while five were on Ebola virus disease. However, one article explored knowledge, preventive practices, and general isolation precautions. The review identified various challenges that hindered the implementation of successful Q&I practices during viral infection outbreaks in Africa. Essential healthcare infrastructure, equipment (medical supplies including personal protective equipment and testing kits) and facilities that are essential for Q&I were deficient. Q&I implementation was often threatened by low human resource capacity and inefficiencies in the healthcare system which portray Africa as unprepared to handle complex public health crises. Conclusions This review shows that Q&I implementation in Africa is often threatened by low human resource capacity and inefficiencies in the healthcare system and also portrays Africa as unprepared to handle complex public health crises. Hence, Q&I for major multicountry outbreaks in Africa is very challenging. Therefore, continuous efforts to address these identified challenges are crucial to enhancing health emergency preparedness in Africa.

Published
2024
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3. Underexplored Molecular Mechanisms of Toxicity

Author

Olatunbosun Arowolo and Alexander Suvorov

Subjects
publication bias, underexplored pathways, toxicity mechanisms, Therapeutics. Pharmacology, RM1-950, Toxicology. Poisons, RA1190-1270
Abstract

Social biases may concentrate the attention of researchers on a small number of well-known molecules/mechanisms leaving others underexplored. In accordance with this view, central to mechanistic toxicology is a narrow range of molecular pathways that are assumed to be involved in a significant part of the responses to toxicity. It is unclear, however, if there are other molecular mechanisms which play an important role in toxicity events but are overlooked by toxicology. To identify overlooked genes sensitive to chemical exposures, we used publicly available databases. First, we used data on the published chemical–gene interactions for 17,338 genes to estimate their sensitivity to chemical exposures. Next, we extracted data on publication numbers per gene for 19,243 human genes from the Find My Understudied Genes database. Thresholds were applied to both datasets using our algorithm to identify chemically sensitive and chemically insensitive genes and well-studied and underexplored genes. A total of 1110 underexplored genes highly sensitive to chemical exposures were used in GSEA and Shiny GO analyses to identify enriched biological categories. The metabolism of fatty acids, amino acids, and glucose were identified as underexplored molecular mechanisms sensitive to chemical exposures. These findings suggest that future effort is needed to uncover the role of xenobiotics in the current epidemics of metabolic diseases.

Published
2024
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4. Pharmacognostic, phytochemical, and chemomicroscopic evaluation of Physalis angulata (L)

Author

Zainab B. Arowolo, Mubarak O. Ameen, Edehia Owen-Obaseki(, Ibrahim B. Gegele, Aliyu Adamu, Ruel C. Samuel, Jemilat A. Ibrahim, and Teghtegh F. Samoh

Subjects
pharmacognostic evaluation, phytochemical screening, physalis angulata, hplc analysis, Science
Abstract

Background/Introduction: Since the start of civilization, human culture has used plants to treat illnesses. Many plant samples have been adulterated intentionally or unintentionally during processing or even misidentified during collection. This study aims at authenticating and standardizing of Physalis angulata by carrying out Pharmacognostic evaluation, HPLC and GCMS analysis. Methodology: The dried leaves of Physalis angulata was extracted with 70% ethanol. Phytochemical screening (qualitative and quantitative screening) analysis was carried out on the ethanolic leave extract using standard method, while the chemical compounds were established with HPLC-DAD and GCMS and Pharmacognostic evaluation was carried out on the powdered leave. Results and discussion: Qualitative phytochemical analysis of the leave extract reveals the presence of flavonoids, terpenes, alkaloid, tannins and saponin while carbohydrate, glycosides and resins were absent. Quantitative phytochemical screening shows alkaloid present to be 2.4±0.4% and saponin 2±1.32%. HPLC analysis reveals the presence of quercetin, rutin, catechin and ferulic acid while GCMS reveals the presence of cyclohexene, Palmitic acid, 17-Octadecynoic acid, 1,2-Benzenedicarboxylic acid and Phytol. Total Ash content is (15.23±0.43) %w/w with acid insoluble ash of (1.16 ±0.28) %w/w, water soluble ash of (8.13 ±0.32) %w/w, moisture content (5.67 ±0.14) %w/w, alcohol soluble extractive value of (5.76 ±0.40) %w/w and water-soluble extractive value of (10.96 ±0.35) %w/w. Chemomicroscopic evaluation indicate the presence of lignin, cellulose, tannins, starch, calcium oxalate, oils and protein. Microscopy, fluorescence and organoleptic analysis were also documented. Conclusion: From this study, the presence of valuable phytochemicals has been established from the plant, while HPLC and GCMS revealed the identities of these compounds. Thus, the physico chemical parameters established for Physalis angulata in this study falls within the range approved by WHO (1992) for crude plant and extract.

Published
2024
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5. Journalism ethics: the dilemma, social and contextual constraints

Author

Lai Oso, Raheemat Adeniran, and Olasunkanmi Arowolo

Subjects
Media ethics, objectivity, media ownership and control, Nigerian media, news routines, Guangchao Charles Feng, School of Communication, Hong Kong Baptist University, Hong Kong, Social Sciences
Abstract

AbstractJournalism, with its claim to professionalism, is guided in its practice by ethical codes which prescribe what is considered ‘good work’. This theoretical article argues that, though based on certain universal prescriptions, ethics is socially and culturally situated. The observance of the codes is socially determined based on the prevailing moral and political conditions. It is also argued that the issue of the type and quality of representations available in the media should also be of concern when we discuss ethics. The article discusses some of the social constraints to the observance of ethics within the Nigerian context and argues for the need to pay greater attention to addressing the material and economic barriers to media access and representation.

Published
2024
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6. Structures, processes and outcomes between first referral and referral hospitals in low-income and middle-income countries: a secondary preplanned analysis of the FALCON and ChEETAh randomised trials

Author

Rajeev Sharma, Neha Mishra, Simon Cousens, Sanjay Gupta, Thomas Pinkney, Neil Smart, Jonathan Cook, Hemanth Kumar, Peter Brocklehurst, Mohammed Bashir, Dmitri Nepogodiev, Adesoji O Ademuyiwa, Philip Alexander, Laura Magill, Rachel Moore, Stephen Tabiri, Joseph Yorke, Dion Morton, Aneel Bhangu, Bryar Kadir, Naveen Sharma, Punam Mistry, Joshua Arthur, Muneer A Malik, Tracy Roberts, Elisee Rwagahirima, Christian Urimubabo, Ewen Harrison, Vijay Kumar, Julia Brown, Pollyanna Hardy, Amit Mahajan, Pratik Solanki, James Glasbey, Himani Gupta, Omar Omar, Joana Simoes, Sivesh K Kamarajah, Adesoji Ademuyiwa, Felix Alakaloko, Olumide Elebute, Omolara Faboya, Justina Seyi-Olajide, Anita Thomas, David Lissauer, Zainab Imam, George Ihediwa, Zainab O Imam, Felix M Alakaloko, Pradeep Zechariah, Suraj Surendran, Olatunji O Lawal, Mohammed Adnan, Savleen Kaur, Faustin Ntirenganya, JC Allen Ingabire, Lawani Ismaïl, Emmy Runigamugabo, Djifid Morel Seto, Paul Wondoh, Charles Dally, Kwabena Agbedinu, Florence Dedey, Enoch Tackie, Frank Enoch Gyamfi, Anthony Davor, Akinlabi Ajao, Omobolaji Ayandipo, Olalekan Ajai, Mobolaji Oludara, Muhammad Daniyan, Danjuma Sale, Lawal Abdullahi, Olabisi Osagie, Adedeji Fatuga, Muzzammil Abdullahi, Manish Pathak, Prashant Singh, Rita Jain, Kwaku Boakye-Yiadom, Kazeem Atobatele, Ayokunle Ogunyemi, Olabode Oshodi, Christopher Bode, Omobolaji O Ayandipo, Akinlabi E Ajao, Godwin Akaba, Gabriella Hyman, Deepak Singh, Olukemi Akande, Sivesh Kathir Kamarajah, Naseem Akhtar, José A Flores, Donna Smith, Olatunji Lawal, Hadijat Olaide Raji, Zafar Khan, Matthew Francis, Emmanuel Williams, Pardeep Kumar, Oliver Samuel, María Paz Muñoz, Arun Chaturvedi, Sameer Gupta, Puneet Prakash, John Raphael, Funmilola Wuraola, Olalekan Olasehinde, Murlidhar V Pai, Deepak Jain, Anwar Sadat Seidu, Victor Ifeanyichukwu Modekwe, Jideofor Okechukwu Ugwu, Lukmon Amosu, Akan Inyang, Michael Amoah, Boateng Nimako, Dhruva Ghosh, Neil Winkles, Olabisi O Osagie, Karolin Kroese, Olubunmi Ogein, Mustapha Yakubu, Vasanth Mark Samuel, Cecil Thomas, Enono Yhoshu, Vishal Michael, William Bhatti, Swati Daniel, Jyoti Dhiman, Atul Suroy, Christopher O Bode, George C Ihediwa, Adaiah Soibi-Harry, Benedetto Osunwusi, Elizabeth Li, Sonia Mathai, Deepak Singla, Farhanul Huda, Aisha Mustapha, Anisah Yahya, Samuel Mensah, Puneet Pareek, Bernard Ofori, Souliath Lawani, Oluwafunmilayo Adeniyi, Opeyemi Rebecca Akinajo, Richard Ofosu-Akromah, Olumide Adeniyi, Adewale O. Adisa, Natacha Boumas, Fareeda Galley, Frank Enoch Gyamfi Parvez D Haque, Antonio Ramos de la Medina, Chukwuma Okereke, Ronald Tubasime, Felicity Brant, Sohini Chakrabortee, Parvez D Haque, Emily Heritage, Carmela Lapitan, Rachel Lillywhite, Pierre Sodonougbo, Pamphile Assouto, Michel Fiogbe, Houenoukpo Koco, Serge Metchinhoungbe, Hodonou Sogbo, Hulrich Behanzin, Yannick Tandje, Sosthène Kangni, Cyrile Kpangon, Marcelin Akpla, Hugues Herve Chobli, Blaise Kovohouande, Gérard Agboton, Rene Ahossi, Raoul Baderha Ngabo, Nathan Bisimwa, Covalic Melic Bokossa Kandokponou, Mireille Dokponou, Francis Moïse Dossou, Corinne Dzemta, Antoine Gaou, Roland Goudou, Emmanuel Hedefoun, Sunday Houtoukpe, Felix Kamga, Eric Kiki- Migan, Ismaïl Lawani, René Loko, Afissatou Moutaïrou, Pencome Ogouyemi, Fouad Soumanou, Pia Tamadaho, Mack-Arthur Zounon, Luke Aniakwo Adagrah, Bin Baaba Alhaji Alhassan, Mabel Pokuah Amoako-Boateng, Anthony Baffour Appiah, Alvin Asante-Asamani, Benedict Boakye, Samuel A Debrah, Donald Enti, Rahman Adebisi Ganiyu, Patience Koggoh, Richard Kpankpari, Isabella Naa M. Opandoh, Meshach Agyemang Manu, Maison Patrick Opoku Manu, Martin Tangnaa Morna, John Nkrumah, Michael Nortey, Emmanuel Owusu Ofori, Elizaberth Mercy Quartson, Esther Adjei-Acquah, Eric Agyemang Vera Agyekum, Rebecca Adjeibah Akesseh, Forster Amponsah-Manu, Ato Oppong Acquah, Leslie Issa Adam-Zakariah, Esther Asabre, Ruby Acheampong Boateng, Barbara Koomson, Ataa Kusiwaa, Emmanuel Yaw Twerefour, James Ankomah, Frank Assah-Adjei, Anthony Appiah Boakye, Godfred Fosu, Godwin Serbeh, Kofi Yeboah Gyan, Isaac Omane Nyarko, Zelda Robertson, Ralph Armah, Christopher Asare, Delali Akosua Gakpetor, Victoria Sena Gawu, Ambe Obbeng, Doris Ofosuhene, Dorcas Osei-Poku, Diana Puozaa, Arkorful Ebenezer Temitope, Regina Acquah, James Amoako, Akosua Dwamena Appiah, Mark Aseti, Charles Banka, Samuel Dadzie, Derick Essien, Romeo Hussey, Jemima Kwarteng, Naa Anyekaa Sowah, Grace Yeboah, Cynthia Yeboah, Kwame Gyambibi Addo, Enoch Appiah Akosa, Percy Boakye, Christian Larbi Coompson, Brian Gyamfi, Bismark Effah Kontor, Christian Kyeremeh, Ruth Manu, Elijah Mensah, Friko Ibrahim Solae, Gideon Kwasi Toffah, Dorcas Otuo Acheampong, Jane Acquaye, Michael Adinku, Anita Eseenam Agbeko, Emmanuel Gyimah Amankwa, George Amoah, Juliana Appiah, Alex Ayim, Emmanuel Kafui Ayodeji, Jonathan Boakye-Yiadom, Edward Amoah Boateng, Christian Kofi Gyasi-Sarpong, Naabo Nuhu Noel Hamidu, Iddrisu Haruna, Naa Kwarley, Agbenya Kobla Lovi, Bertina Beauty Nyadu, Dominic Opoku, Anita Osabutey, Robert Sagoe, Samuel Tuffour, Yaa Tufour, Francis Akwaw Yamoah, Abiboye Cheduko Yefieye, Nii Armah Adu-Aryee, Faisal Adjei, Erica Akoto, Elikem Ametefe, Joachim Kwaku Amoako, Godsway Solomon Attepor, George Darko Brown, Benjamin Fenu, Philemon Kwame Kumassah, David Olatayo Olayiwola, Theodore Wordui, Nelson Agboadoh, Fatao Abubakari, Cletus Ballu, Charles Gyamfi Barimah, Guy Casskey Boateng, Prosper Tonwisi Luri, Abraham Titigah, Frank Owusu, Raphael Adu-Brobbey, Abdul-Hamid Labaran, Junior Atta Owusu, Vivian Adobea, Amos Bennin, Fred Dankwah, Stanley Doe, Ruth Sarfo Kantanka, Ephraim Kobby, Kennedy Kofi Korankye Hanson Larnyor, Edwin Osei, Prince Yeboah Owusu, Clement Ayum Sie-Broni, Marshall Zume, Francis Atindaana Abantanga, Darling Ramatu Abdulai, Daniel Kwesi Acquah, Emmanuel Ayingayure, Imoro Osman, Sheba Kunfah, Gbana Limann, Shamudeen Alhassan Mohammed, Sheriff Mohammed, Yakubu Musah, Emmanuel Abem Owusu, Abdul-Hafiz Saba, Edwin Mwintiereh Ta-ang Yenli, Arun Gautham, Alice Hepzibah, Grace Mary, Dimple Bhatti, Karan Bir, Tapasya Dhar, Sunita Goyal, Goyal Ankush, Monika Hans, Parvez Haque, Samuel Konda, Anil Luther, Shalini Makkar, Kavita Mandrelle, Partho Mukherjee, Reuben Rajappa, Ravinder Thind, Alen Thomas, Arti Tuli, Sreejith Veetil, Esther Daniel Mark Jesudason, K Priyadarshini, Latha Madankumar, Rohin Mittal, Ida Nagomy, Rajesh Selvakumar, Bharat Shankar, Moonish Sivakumar, Rajeevan Sridhar, Devabalan Titus, Manisha Aggarwal, Parth Dhamija, Vinoth Kanna, Ashwani Kumar, Gurtaj Singh, Josy Thomas, Amos Dasari, Priya Jacob, Elizabeth Kurien, Arpit Mathew, Danita Prakash, Anju Susan, Rose Varghese, Rahul Alpheus, Ashish Choudhrie, Nitin Peters, Subrat Raul, Rakesh Vakil, Wenceslao Ángeles Bueno, Francisco Barbosa Camacho, Aldo Bernal Hernández, Ana Bogurin Arellano, Edgar Cortes Torres, Clotilde Fuentes Orozco, Erick González García de Rojas, Alejandro González Ojeda, Bertha Guzmán Ramírez, Michel Hernández Valadez, Diego Luna Acevedo, Rubén Morán Galaviz, Oscar Olvera Flores, José Pérez Navarro, Kevin Pintor Belmontes, Fernando Ramirez Marbello, Luis Ramírez-González, Laura Reyes Aguirre, Ramona Rojas García, Eduardo Valtierra Robles, Reyes Cervantes Ortiz, Gonzalo Hernandez Gonzalez, Rosa Hernandez Krauss, Luis Hernández Miguelena, Marco Hurtado Romero, Isaac Baltazar Gomez, Celina Cuellar Aguirre, Alejandro Cuevas Avendaño, Luis Dominguez Sansores, Hector Ortiz Mejia, Laura Urdapilleta Gomez del Campo, Claudia Caballero Cerdan, David Dominguez Solano, Rafael Toriz Garcia, Mariana Barreto Gallo, Ana Cortes Flores, Alejandro Gonzalez Ojeda, Monica Jimenez Velasco, Rozana Reyes Gamez, Roque Lincona Menindez, Alberto Navarrete Peón, Irani Durán Sánchez, Diana Gonzalez Vazquez, Maria Martínez Lara, Laura Martinez Perez Maldonado, Alejandra Nayen Sainz de la Fuente, Antonio Ramos De la Medina, Khadija Ado, Mohammed Aliyu, Lofty-John Anyanwu, Mahmoud Magashi, Abubakar Muhammad, Saminu Muhammad, Bello Muideen, Idris Takai, Onyekachi Ukata, Opeoluwa Adesanya, David Awonuga, Olushola Fasiku, Chidiebere Ogo, Moruf Abdulsalam, Abimbola Adeniran, Grace Eke, Esther Momson, Francisca Nwaenyi, Olufunmilade Omisanjo, Yusuf Oshodi, Yemisi Oyewole, Omotade Salami, Omolara Williams, Victoria Adeleye, Opeyemi Akinajo, David Akinboyewa, Iyabo Alasi, Oluwole Atoyebi, Olanrewaju Balogun, Orimisan Belie, Andrew Ekwesianya, Francis Ezenwankwo, Adesola Jimoh, Jubril Kuku, Oluwaseun Ladipo- Ajayi, Ayomide Makanjuola, Olayanju Mokwenyei, Samuel Nwokocha, Rufus Ojewola, Abraham Oladimeji, Thomas Olajide, Oluwaseun Oluseye, Aloy Ugwu, Ochomma Egwuonwu, Okechukwu Ekwunife, Victor Modekwe, Chukwuemeka Okoro, Chisom Uche, Kenneth Ugwuanyi, Chuka Ugwunne, Akeem Adeleke, Wilson Adenikinju, Akinfolarin Adepiti, Adewale Aderounmu, Abdulhafiz Adesunkanmi, Adewale Adisa, Samuel Ajekwu, Olusegun Ajenjfuja, Jerrie Akindojutimi, Akinbolaji Akinkuolie, Olusegun Alatise, Olubukola Allen, Micheal Archibong, Olukayode Arowolo, Deborah Ayantona, Ademola Ayinde, Olusegun Badejoko, Tajudeen Badmus, Amarachukwu Etonyeaku, Emeka Igbodike, Omotade Ijarotimi, Adedayo Lawal, Fayowole Nana, Tunde Oduanafolabi, Olaniyi Olayemi, Stephen Omitinde, Owolabi Oni, Chigozie Onyeze, Ernest Orji, Adewale Rotimi, Abdulkadir Salako, Olufemi Solaja, Oluwaseun Sowemimo, Ademola Talabi, Mohammed Tajudeen, Francis Adebayo, Oseremen Aisuodionoe- Shadrach, Lazarus Ameh, Ndubuisi Mbajiekwe, Felix Ogbo, Samson Olori, Samuel Sani Abu Sadiq, Nancy Tabuanu, Martins Uanikhoba, Godwin Chiejina, Ekpo Edet, Mary Isa, Faith Iseh, Adams Marwa, Sunday Ogbeche, Edima Olory, Gabriel Udie, Joseph Udosen, Usang Usang, Olukayode Abayomi, Rukiyat Abdus-Salam, Sikiru Adebayo, Olanrewaju Amusat, Kelvin Egbuchulem, Hyginus Ekwuazi, Peter Elemile, Taiwo Lawal, Solomon Olagunju, Peter Osuala, Bamidele Suleman, Augustine Takure, Lukman Abdur-Rahman, Nurudeen Adeleke, Muideen Adesola, Rafiat Afolabi, Sulaiman Agodirin, Isiaka Aremu, Jibril Bello, Saheed Lawal, Abdulwahab Lawal, Hadijat Raji, Olayinka Sayomi, Asimiyu Shittu, Jude Ede, Sebastian Ekenze, Vincent Enemuo, Matthew Eze, Uchechukwu Ezomike, Emmanuel Izuka, Okezie Mbadiwe, Ngozi Mbah, Uba Ezinne, Iweha Ikechukwu, Okoi Nnyonno, Philemon Okoro, Igwe Patrick, Oriji Vaduneme, Abhulimen Victor, Salathiel Kanyarukiko, Francine Mukaneza, Deborah Mukantibaziyaremye, Aphrodis Munyaneza, Gibert Ndegamiye, Ronald Tubasiime, Moses Dusabe, Emelyne Izabiriza, Hope Lydia Maniraguha, Christophe Mpirimbanyi, Josiane Mutuyimana, Olivier Mwenedata, Francine Uwizeyimana, Job Zirikana, Aime Dieudonne Hirwa, Elysee Kabanda, Salomee Mbonimpaye, Christine Mukakomite, Piolette Muroruhirwe, Georges Bucyibaruta, Gisele Juru Bunogerane, Sosthene Habumuremyi, Jean de Dieu Haragirimana, Alphonsine Imanishimwe, Violette Mukanyange, Emmanuel Munyaneza, Emmanuel Mutabazi, Isaie Ncogoza, Jeannette Nyirahabimana, Mary Augusta Adams, Richard Crawford, Chikwendu Jeffrey Ede, Maria Fourtounas, Morapedi Kwati, Mpho Nosipho Mathe, Ncamsile Anthea Nhlabathi, Hlengiwe Samkelisiwe Nxumalo, Paddy Pattinson, Nnosa Sentholang, Mmule Evelyn Sethoana, Maria Elizabeth Stassen, Laura Thornley, Cheryl Birtles, Mathete Ivy, Cynthia Mbavhalelo, Zain Ally, Abdus-sami Adewunmi, Maria Picciochi, Michael Bahrami-Hessari, Didier Ahogni Benin, Aristide Ahounou, K. Alassan Boukari, Oswald Gbehade, Thierry K Hessou, Sinama Nindopa, M.J. Bienvenue Nontonwanou, Nafissatou Orou Guessou, Arouna Sambo, Sorekou Victoire Tchati, Affisatou Tchogo, Semevo Romaric Tobome, Parfait Yanto, Isidore Gandaho, Armel Hadonou, Simplice Hinvo, Montcho Adrien Hodonou, Sambo Bio Tamou, Marie-Claire Kouroumta, Enrif Malade, Anne stredy Mkoh Dikao, Joel Nzuwa Nsilu, Nathan Bisimwa Mitima, Cyrille Kpangon, Stephane Laurent Loupeda, Mamonde Victorin Agbangla, Sena Emmanuel Hedefoun, Thierry Mavoha, Juvenal Ngaguene, Janvier Rugendabanga, Rish Romaric Soton, Martin Totin, Mouhamed Agbadebo, Irene Akpo, Hubert Dewamon, Martin Djeto, Aissatou Hada, Monsede Hollo, Albert Houndji, Anasthasie Houndote, Sylvestre Hounsa, Expedit Kpatchassou, Hugues Yome, Mohamed Moussa Alidou, Bonheur Dossou Yovo, Robert Guinnou, Souleymane Hamadou, Nabil Moussa, Boniface Cakpo, Lolyta Etchisse, Emery Hatangimana, Moise Muhindo, Katia Sanni, Agossou Barthelemy Yevide, Hermann Agossou, Fiston Basirwa Musengo, Bill Armstrong Alia, Arnaud Alitonou, Lucien Agbanda, Julien Attinon, Marcel Gbassi, Nounagnon Rene Hounsou, Derick Esssien, Yakubu Mustapha, Kojo Nunoo-Ghartey, Luke A Aniakwo, Margarey N M Adjei, Yvonne Adofo-Asamoah, Meshach M Agyapong, Thomas Agyen, Baba A B Alhassan, Mabel P Amoako-Boateng, Josephine Ashong, Joseph K Awindaogo, Benjamin B Brimpong, Makafui S C J K Dayie, Wendy W Ghansah, Jude E Gyamfi, Vincent Kudoh, Philip Mensah, Isabella N Morkor Opandoh, Martin T Morna, Emelia Odame, Emmanuel O Ofori, Sandra Quaicoo, Elizabert M Quartson, Cynthia Teye-Topey, Makafui Yigah, Safia Yussif, Vera O Agyekum-Gyimah, Eric Agyemang, Arko Akoto- Ampaw, Temitope E Arkorful, Moses A Dokurugu, Nanabanyin Essel, Aja Ijeoma, Emmanuel L Obiri, Karen N D Quarchey, Leslie Adam-Zakariah, Aaron B Andoh, Ruby A Boateng, Atta Kusiwaa, Adeline Naah, Ato Oppon-Acquah, Benjamin A Oppong, Emma A Agbowada, Ameley Akosua, O Lawrence Dorcas Acheampong, Frank E Gyamfi, Bertina B Nyadu, Samira Abdulai, Nii A Adu-Aryee, Joachim K Amoako, Nicholas T Aperkor, Wilfred K Asman, Godsway S Attepor, Antoinette A Bediako-Bowan, George D Brown, Victor K Etwire, Benjamin S Fenu, Philemon K Kumassah, Linda A Larbi-Siaw, Josephine Nsaful, David O Olatola, Sandra E Tsatsu, Iddrisu I A Abdul-Aziz, Johnson Akunyam, Gilbert A G Anasara, Charles G Barimah, Guy C Boateng, Ponala W Kwabena, Seidu M Kwarteng, Prosper T Luri, Kennedy Ngaaso, David K D Ogudi, Collins Kyeremeh, Clement Sie-Broni, Saba Abdul-Hafiz, Daniel K Acquah, Shamsudeen M Adams, Mohammed S Alhassan, Munira Amadu, Samuel A Asirifi, Martin Awe, Millicent Azanlerigu, Mathias K Dery, Yenli Edwin, Abantanga Atindaana Francis, Aloysius Maalekuu, Hawa Malechi, Ibrahim Mohammed, Kareem Mumuni, Bernard A Ofori, Jonathan I K Quansah, Napoleon Bellua Sam, Anwar S Seidu, Shekira Yahaya, Emmanuel Kojo Acquah, Jaabir Alhassan, Christian L Coompson, Addo K Gyambibi, Ametepe Jeffery-Felix, Bismark E Kontor, Gifty Naah, Carmen Noufuentes, Abraham Sakyi, Ramkaran Chaudhary, Sanjeev Misra, Dharma R Poonia, Kirti K Rathod, Mahaveer S Rodha, Nivedita Sharma, Subhash C Soni, Vaibhav K Varsheney, Jeevan R Vishnoi, Deepak K Garnaik, Manoj J Lokavarapu, Rohit Ranjan, Rajkumar K Seenivasagam, Shanky Singh, Raunak Verma, Suzan John, Jeffery A Kalyanapu, Ananta Kutma, Sanish Philips, Arun K Gautham, Deepak S Singh, Eunice S Abraham, Chetana Chetana, Prashant Dummala, Chinta S Gold, Jurgen Jacob, Jeremiah N Joseph, Elizabeth N Kurien, Priya Mary, Arpit J Mathew, Amy E Mathew, Danita D Prakash, Ashwin Sukumar, Niyah Syam, Alisha Bhatt, Dhruva N Ghosh, Ankush Goyal, Monika A Hans, Jyoti Jyoti, Karan Kumar, Vivin Daniel Sam, Ravinder Singh Thind, Sreejith K Veetil, Rahul Williams, D Sreekar, Esther R Daniel, Smitha E Jacob, Mark R Jesudason, Pushplatha Kumari, Soosan Prasad, Srujan Sharma, Moonish V Sivakumar, Paul Trinity, Sudheer Kanchodu, K Leshiini, Sundeep S Saluja, Ashok K Attri, Ishan Bansal, Monika Gureh, Simran Kapoor, Harmanjot Kaur, Simrandeep Singh, Viju John, Nivesh Agrawal, Uttkarsh Kumar, S Abhishek, Vikram Sehrawat, Gaurav Thami, Stanley Mathew, P S Prabhu, P T Sundeep, Shiv Rajan, Mohit Singh, Abhilasha Tripathi, Philip V Alexander, A Vijay, Moloti Kichu* Ismavel, Carolin V Solomi, Rahul A Alpheus, Ashish Victor Choudhrie, Rashmi Jacob Gunny, Susan Joseph, Nitin J Peters, Neha Pundir, Ram Samujh, Hafsa I Ahmed, Gowhar Aziz, Nisar A Chowdri, Rayees A Dar, Robindera Kour, Imtiyaz Mantoo, Asif Mehraj, Fazl Q Parray, Najmus Saqib, Zamir A Shah, Rauf A Wani, Komal Rautela, Nishu Singh, Priyanka Chowdhury, Sona Chowdhury, Pragyanmai Nayak, Bipradas Roy, Andrea S Alvarez Villaseñor, Kriscia V Ascencio Díaz, Victor J Avalos Herrera, Francisco J Barbosa, Elyoenai Bonilla Ahumada, Irma V Brancaccio, Miguel A Calderón, Guadalupe Castillo Cardiel, Guillermo A Cervantes, Gabino Cervantes Guevara, Enrique Cervantes Perez, Maria Chávez, Jonathan M Chejfec, Luis R Cifuentes, Ana O Cortés, Edgar J Cortes, Tania A Cueto, Andrea E Cueto, Esteban Cueva Martinez, Paulina Domínguez Barradas, Isaac Esparza Estrada, Paola Flores Becerril, Luis A García, Benjamín García Reyna, Eduardo Gómez Sánchez, Jaime L González, Eduardo González Espinoza, Fanny Y González, Cristhian S Guerrero, José A Guzmán, Bertha G Guzmán, Mario J Guzmán, DanielA Hérnandez Alva, SilviaA Ibarra Camargo, JuanC Ibarrola Peña, Martin Islas Torres, Jorge Jiménez Tornero, ZayraM Lara Pérez, Roberto Mares País, MelP Mellado Tellez, RobertoC Miranda Ackerman, Damián Mora Santana, Gilberto Morgan Villela, Rodrigo Nájar Hinojosa, Cesar Nuño Escobar, Itzel Ochoa Rodríguez, Angelica Ortega Barreiro, Jacqueline Osuna Rubio, Luis RPacheco Vallejo, VíctorH Pérez Bocanegra, JoseV Pérez Navarro, Francisco JPlascencia Posada, MaríaA Quirarte Hernández, LuisR Ramirez Gonzalez, Emilio AReyes Elizalde, EveliaV Romo Ascencio, Cornelio Ruelas Bravo, CarlosB Ruiz Velasco, JoséA Sánchez Martínez, Guillermo Sanchez Villaseñor, JoséI Sandoval Pulido, AlejandroG Serrano García, LuisO Suárez Carreón, JuanJ Tijerina Ávila, JesusO Vega Gastelum, MelissaL Vicencio Ramirez, MariaF Zarate Casas, CarlosJ Zuloaga, Fernández del Valle, JesusAntonion Aguilar Mata, MiguelAntonio Calderon Vanegas, RocioGuadalupe Cano Arias, Carlos Colunga Tinajero, Fernanda Diaz Samano, Fernando Duque Zepeda, BrendaVanessa Enriquez Barajas, Gerardo Gallardo Banuelos, MarijoseDe CristoGonzalez Calvillo, Francisco Ibanez Ortiz, Maryzela Lazo Ramirez, Gerardo Lopez Arroyo, LauraOlivia Montano Angeles, DavidGiovannyI Morales Iriarte, AngeloFernando Mortola Lomeli, Jose EstebanOrozco Navarro, Jaime Orozco Perez, Damaris Orozco Ramirez, LauraGabriela Pena Baolboa, Jesus Pizarro Lozano, Guillermo Yanowsky Reyes, Monica N Castillo, Ana CamilleG Dominguez, Dorihela H Mellado, Jesus FlavioM Morales, Luzdel CarmenM Namur, Jose AlbertoA Pesquera, LauraMartinez Perez Maldonado, Antonio RamosDe laMedina, Katya Bozada-Gutierrez, AnaFlorencia Casado-Zarate, Roberto Delano-Alonso, Jose Herrera-Esquivel, Mucio Moreno-Portillo, Mario Trejo-Avila, Roland Kevin CethorthFonseca, Edgard Efren LozadaHernandez, Bruno Crocco Quiros, JairoArturo Rodriguez Ramirez, Gabriela Ambriz-González, MitziR Becerra Moscoso, Ishtar Cabrera-Lozano, AnaB Calderón-Alvarado, FranciscoJ León-Frutos, ErickE Villanueva-Martínez, Aisha Abdullahi, Maimuna Abubakar, MohammedS Aliyu, Mudi Awaisu, Fadimatu Bakari, Abigail Olajumoke Balogun, Ahmad Bello, Kehinde Michael Duromola, Stephen G Gana, Mukoro Duke George, Justina Gimba, Isaac Gundu, Lambert Onahi Iji, Aminat O Jimoh, Afolabi K Koledade, Ahmad T Lawal, Bilkisu K Lawal, Stanley Emeka Nwabuoku, Oluseyi O Ogunsua, Ifeanyi Fidelis Okafor, Ethos Ike Okorie, Nasir Oyelowo, Ibrahim A Saidu, Tunde T Sholadoye, Ibrahim Sufyan, Musliu Adetola Tolani, Aliyu Muhammad Tukur, Ahmad Shehu Umar, Aminatu M Umar, Hajara Umaru-Sule, Mohammed Usman, Alfa Yakubu, Salisu Abeku Yusuf, Abdulhafiz A Abdulkarim, Lawal Barau Abdullahi, Khadija A Ado, Nura U Aliyu, Lofty-John Chukwuemeka Anyanwu, Sulaiman M Daneji, Mahmoud Kawu Magashi, Mohammad A Mohammad, Abubakar Bala Muhammad, Saminu S Muhammad, Bello Abodunde Muideen, Calistus U Nwachukwu, Suleiman B Sallau, Abdulrahman A Sheshe, Abdulmajeed Soladoye, Idris Usman Takai, Garzali I Umar, Abubakar Yahaya, Lubabatu Abdulrasheed, Joel A Adze, Lydia R Airede, Bashiru Aminu, Stephen B Bature, Firdaws Bello-Tukur, Damai Chinyio, SharonA N Duniya, Moses C Galadima, Babatunde K Hamza, Samaila Joshua, Stephen A Kache, Williams Y Kagomi, Ifeanyi A Kene, Jamila Lawal, Jerry G Makama, Caleb Mohammed, Amina A Mohammed-Durosinlorun, Deborah Nuwam, Abdulrasheed Sani, Salome Tabara, Mathew C Taingson, Emmanuel Usam, Josiah Yakubu, Folasade Adegoke, Oluwasuyi Ige, Tunde A Odunafolabi, Chukwuma E Okereke, Oluwafemi O Oladele, Oluwaseun H Olaleye, Oyetunde O Olubayo, Olukayode P Abiola, Henry O Abiyere, Idowu O Adebara, GbadeboT C Adeleye, Adebayo A Adeniyi, Olumide E Adewara, Olabisi T Adeyemo, Ademola A Adeyeye, Abimbola L Ariyibi, Babatunde S Awoyinka, Olumide M Ayankunle, Olakunle F Babalola, Adewumi Bakare, TajudeenI B Bakare, Oluseyi O Banjo, Peter A Egharevba, Oluwafemi S Fatudimu, John A Obateru, Oluremi J Odesanya, Owolabi D Ojo, Abiodun I Okunlola, Cecilia K Okunlola, Adewale T Olajide, Tesleem O Orewole, Adedayo I Salawu, Moruf A Abdulsalam, Aderinsola T Adelaja, Olalekan T Ajai, Noble Anyanwu, Kazeem M Atobatele, Oludayo Oluwaseyi Bakare, Omolara M Faboya, Francisca C Nwaenyi, Ayokunle A Ogunyemi, Mobolaji A Oludara, Olufunmilade A Omisanjo, Chinonso U Onyeka, Olabode A Oshodi, Yusuf A Oshodi, Omotade S Salami, Omolara M Williams, Esther Abunimye, Adebunmi Adeoluwa, Adedotun Adesiyakan, Victoria Ibukunoluwa Adeyeye, Moses Vincent Agbulu, David O Akinboyewa, Iyabo O Alasi, Michael Amao, Christiana Ashley-Osuzoka, Oluwole A Atoyebi, Olanrewaju S Balogun, Maryam Oluwatobi Busari, Nnamdi Jonathan Duru, Glory Bassey Edet, Olumide A Elebute, Francis Chinonso Ezenwankwo, Adedeji L Fatuga, Christianah Gbenga-Oke, Emmanuel Sylvester Inyang, Adesola I Jimoh, Jubril Oladayo Kuku, OluwaseunA Ladipo-Ajayi, Abdulrazzaq O Lawal, Christian Chigoze Makwe, Chinelo Victoria Mgbemena, Samuel U Nwokocha, Moses Adebisi Ogunjimi, Ephraim Okwudiri Ohazurike, Rufus W Ojewola, Moyosoluwa Eunice Badedale, Chike J Okeke, Adeyemi A Okunowo, Abraham T Oladimeji, Thomas O Olajide, Olabisi Olanrewaju, Olawunmi Olayioye, Oluwaseun O Oluseye, Stephen Olutola, Kenneth Onyekachi, Adeola Ayoola Orowale, Emili Osariemen, Adedapo Olumide Osinowo, Emmanuel Owie, Christianah Bidemi Oyegbola, Justina OSeyi-Olajide, AdaiahP Soibi-Harry, Manuella Talla Timo, Aloy Okechukwu Ugwu, Emmanuel Ojo Williams, Innocent O Duruewuru, Ochonma A Egwuonwu, Okechukwu Hyginus Ekwunife, James J Emeka, Chimdiebele Daisy Nwosu, Sylvester O Obiechina, Ahuizechukwu E Obiesie, Celestine I Okafor, Theophilus O Okonoboh, Odili A Okoye, Onyekachi A Onu, Chukwudubem C Onyejiaka, Chisom Faith Uche, JosephO Ugboajah, Akeem A Adeleke, Akinfolarin C Adepiti, Adewale A Aderounmu, Abdulhafiz O Adesunkanmi, Adewale O Adisa, Samuel C Ajekwu, Olusegun K Ajenifuja, Olusegun I Alatise, Tajudeen A Badmus, Tajudeen O Mohammed, Abdulkadir A Salako, Oludayo A Sowande, Ademola O Talabi, Funmilola O Wuraola, Paul Aderemi Adegoke, Abidemi Akinloye, Ayodeji Akinniyi, Joseph Ejimogu, Ideyonbe Samuel Eseile, Olakayode Olaolu Ogundoyin, Amos Okedare, Dare Isaac Olulana, Omolara Omotola, Francis Sanwo, Collins C Adumah, Adewale O Ajagbe, Olugbenga P Akintunde, Opeyemi Q Asafa, Kehinde Awodele, Amogu K Eziyi, Adeniyi O Fasanu, Olufemi O Ojewuyi, Abiodun R Ojewuyi, Abisola E Oyedele, Oluwaseun A Taiwo, Habiba I Abdullahi, Nathaniel D Adewole, Teddy E Agida, Eunice E Ailunia, Oseremen Aisuodionoe-Shadrach, Godwin O Akaba, Janet Alfred, Terkaa Atim, Kehinde G Bawa, John Y Chinda, Esther B Daluk, Sefiu B Eniola, Augusta O Ezenwa, Stephen E Garba, Philip M Mshelbwala, Ngozi O Ndukwe, Idoko P Ogolekwu, Alexander A Ohemu, Samuel A Sani, Salisu Suleiman, Helen Sunday, Nancy O Tabuanu, Aminu M Umar, Peter I Agbonrofo, Alexander I Arekhandia, Morrison E Edena, Raymond A Eghonghon, Joel E Enaholo, Genesis Ida, Stanley N Ideh, Oseihie I Iribhogbe, Omorodion O Irowa, Maradona E Isikhuemen, Oluwatomi R Odutola, Kester O Okoduwa, Scott O Omorogbe, David Oruade, Osasumwen T Osagie, Osarenkhoe Osemwegie, RukiyatA Abdus-Salam, Sikiru Adekola Adebayo, Oluwasanmi A Ajagbe, Gboyega Ajibola, Kelvin I Egbuchulem, Hyginus O Ekwuazi, Adegbolahan Fakoya, Oluwasegun C Idowu, David O Irabor, Taiwo A Lawal, Olakayode O Ogundoyin, Oluwabukade Ojediran, Naomi Olagunju, Akinsola T Sanusi, Augustine O Takure, Lukman Olajide Abdur-Rahman, Mary Oluwadamilola Adebisi, Nurudeen Abiola Adeleke, Rafiat Tinuola Afolabi, Isiaka Ishola Aremu, Jibril Oyekunle Bello, Robiat Bello, Saheed Abolade Lawal, Adeolu Ojajuni, Sabur Oyewale, Victor Abhulimen, Patrick O Igwe, Ikechukwu Enyinnaya Iweha, Raphael E John, Nnyonno Okoi, Philemon E Okoro, Vaduneme Kingsley Oriji, Ibiene T Oweredaba, Japhet Mizero, Immaculee Mutimamwiza, Francoise Nirere, Irenee Niyongombwa, Jean Paul Majyabere, Anastase Byaruhanga, Rongin Dukuzimana, Jean Aimable Habiyakare, Marie Gloriose Nabada, Marcel Uwizeye, Mathias Ruhosha, Joselyne Igiraneza, Faustine Ingabire, Aloys Karekezi, Jean pierre Masengesho, Lydia Mukamazera, Clemence Mukangabo, Jean Paul Niyomuremyi, Gabriel Ntwari, Celestin Seneza, Divine Umuhoza, Pierrine Nyirangeri, Jean Claude Uwimana, Isaie Sibomana, Desire Rubanguka, Josine Umuhoza, Roda Uwayezu, Leoncie Uzikwambara, Herbert Butana, Moise Dusabeyezu, Athanasie Mukasine, Jean N Utumatwishima, Mediatrice Batangana, Jeande Dieu Haragirimana, AllenJ C Ingabire, Espoir Mwungura, Dancilla Nyirasebura, Christian Jean Urimubabo, Anaclet Dusabimana, Sam Kanyesigye, Robert Munyaneza, Jean Yves Shyirakera, Aimee Domingo, Philip Munda, Chido Nyatsambo, Victor Ojo, Rudo Pswarayi, and Soeren Laurberg

Subjects
Medicine (General), R5-920, Infectious and parasitic diseases, RC109-216
Published
2024
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7. Electric mobility investment in the power and transport sector coupling context: Lessons from Argentina, the Philippines, Poland and Romania

Author

Wale Arowolo and Yannick Perez

Subjects
Investment, Electric mobility, Energy transition, Developing countries, Decarbonisation, Digitalisation, Transportation and communications, HE1-9990
Abstract

Many developing countries are at a crucial juncture in road transport electrification with electric mobility because they have limited economic capacity to implement government policy support and financial mechanisms that have spurred the capital-intensive electric mobility growth in developed countries. Attracting private sector investments remains a viable option for developing countries. While investors have identified opportunities to invest in developing countries, it remains to be seen which countries to prioritise, considering the complexities involved in investment decision-making despite the availability of myriad investment appraisal tools. This paper contributes to this academic and policy debate. With a power and transport sector coupling viewpoint, we explain the interaction of the power and transport sectors in the context of decarbonisation and digitalisation to identify developing countries that could be considered for private sector investment in electric mobility. Then, we apply our framework to case studies of the Philippines, Argentina, Romania, and Poland. We argue that countries with wholesale power markets and wholesale and retail power markets could attract electric mobility investment. We offer policy recommendations to stakeholders interested in electric mobility investment issues in developing countries.

Published
2024
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8. A scoping review of cultural issues concerning institutional quarantine and isolation during major multi‐country outbreaks in Africa: 2000–2023

Author

Ebunoluwa Oduwole, Jimoh Amzat, Olusola Aluko‐Arowolo, Rotimi Afolabi, Isaac Akinkunmi Adedeji, Saheed Akinmayowa Lawal, Ige Angela Temisan, Ayoyinka Oludiran, Kafayat Aminu, Afeez Abolarinwa Salami, and Kehinde Kazeem Kanmodi

Subjects
Africa, cultural issues, outbreaks, pandemic, quarantine and isolation, review, Medicine
Abstract

Abstract Background and Aims Infectious disease outbreaks pose significant challenges in Africa due to its ecology, socioeconomic conditions, and weak health systems. Implementing institutional quarantine and isolation (Q&I) measures is crucial for managing major outbreaks. However, the cultural context often determines the success of these measures. This scoping review aims to examine existing evidence on the cultural aspects of institutional Q&I in Africa over the past two decades, focusing on the COVID‐19 pandemic and other major multi‐country disease outbreaks. Methods This scoping review's protocol was registered with the Open Science Framework registry. Nine research databases were systematically searched to retrieve all relevant literature, followed by deduplication and a two‐stage screening process using the Rayyan web application. The inclusion of any literature into this review was based on a set of eligibility criteria. Also, manual searching of the reference lists of included literature was done to retrieve any other eligible literature. From the included literature, data were charted, collected, and summarized. Findings Out of the 787 articles retrieved from the database searches, this review found only one to be eligible for inclusion. Also, no other eligible article was obtained after manual searching of the reference list for this article. The reviewed article presented empirical findings on the impact of COVID‐19 Q&I protocols on traditional burial rites in Ghana. Many Ghanaian families were against their country's protocol because they felt it was insensitive to their traditional values and burial practices. Also, the way the protocol was implemented made some Ghanaian families feel that foreign burial practices were imposed on them, which bred feelings of cultural exclusion and neglect (by the government) among Ghanaians. Conclusion Research evidence on the cultural implications of Q&I in Africa is very scanty. More research is needed on this topic of public health interest.

Published
2024
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15. Image Augmentation for Satellite Images

Author

Adedeji, Oluwadara, Owoade, Peter, Ajayi, Opeyemi, and Arowolo, Olayiwola

Subjects
Computer Science - Computer Vision and Pattern Recognition, Computer Science - Artificial Intelligence, Computer Science - Machine Learning, Electrical Engineering and Systems Science - Image and Video Processing
Abstract

This study proposes the use of generative models (GANs) for augmenting the EuroSAT dataset for the Land Use and Land Cover (LULC) Classification task. We used DCGAN and WGAN-GP to generate images for each class in the dataset. We then explored the effect of augmenting the original dataset by about 10% in each case on model performance. The choice of GAN architecture seems to have no apparent effect on the model performance. However, a combination of geometric augmentation and GAN-generated images improved baseline results. Our study shows that GANs augmentation can improve the generalizability of deep classification models on satellite images., Comment: 14 pages, 4 figures, 6 tables. Research project for Introduction to Deep Learning (11785) at Carnegie Mellon University

Published
2022

16. Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation

Author

Saira Amir, Olatunbosun Arowolo, Ekaterina Mironova, Joseph McGaunn, Oladele Oluwayiose, Oleg Sergeyev, J Richard Pilsner, and Alexander Suvorov

Subjects
rejuvenation, aging, DNA methylation, epigenetic, mTOR, sperm, Medicine, Science, Biology (General), QH301-705.5
Abstract

Over the past several decades, a trend toward delayed childbirth has led to increases in parental age at the time of conception. Sperm epigenome undergoes age-dependent changes increasing risks of adverse conditions in offspring conceived by fathers of advanced age. The mechanism(s) linking paternal age with epigenetic changes in sperm remain unknown. The sperm epigenome is shaped in a compartment protected by the blood-testes barrier (BTB) known to deteriorate with age. Permeability of the BTB is regulated by the balance of two mTOR complexes in Sertoli cells where mTOR complex 1 (mTORC1) promotes the opening of the BTB and mTOR complex 2 (mTORC2) promotes its integrity. We hypothesized that this balance is also responsible for age-dependent changes in the sperm epigenome. To test this hypothesis, we analyzed reproductive outcomes, including sperm DNA methylation in transgenic mice with Sertoli cell-specific suppression of mTORC1 (Rptor KO) or mTORC2 (Rictor KO). mTORC2 suppression accelerated aging of the sperm DNA methylome and resulted in a reproductive phenotype concordant with older age, including decreased testes weight and sperm counts, and increased percent of morphologically abnormal spermatozoa and mitochondrial DNA copy number. Suppression of mTORC1 resulted in the shift of DNA methylome in sperm opposite to the shift associated with physiological aging – sperm DNA methylome rejuvenation and mild changes in sperm parameters. These results demonstrate for the first time that the balance of mTOR complexes in Sertoli cells regulates the rate of sperm epigenetic aging. Thus, mTOR pathway in Sertoli cells may be used as a novel target of therapeutic interventions to rejuvenate the sperm epigenome in advanced-age fathers.

Published
2024
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18. Hospitalized Patients With COVID-19 Have Higher Plasma Aldosterone-Renin Ratio and Lower ACE Activity Than Controls

Author

Parikh, Nisha I, Arowolo, Folagbayi, Durstenfeld, Matthew S, Nah, Gregory, Njoroge, Joyce, Vittinghoff, Eric, Long, Carlin S, Ganz, Peter, Pearce, David, Hsue, Priscilla, Wu, Alan HS, Hajizadeh, Negin, Liu, Kathleen D, and Lynch, Kara L

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Cardiovascular, Lung, Good Health and Well Being, COVID-19, renin-aldosterone ratio, hospitalization, severity, renin-angiotensin aldosterone system, obesity, ACE-2, biomarkers, Cardiovascular medicine and haematology
Abstract

ContextSARS-CoV-2 infects cells via the angiotensin converting enzyme 2 (ACE2) receptor, whose downstream effects "counterbalance" the classical renin angiotensin aldosterone system (RAAS).ObjectiveWe aimed to determine to what extent circulating RAAS biomarker levels differ in persons with and without COVID-19 throughout the disease course.MethodsWe measured classical (renin, aldosterone, aldosterone/renin ratio [ARR], Ang2, ACE activity) and nonclassical (ACE2, Ang1,7) RAAS biomarkers in hospitalized COVID-19 patients vs SARS-CoV-2 negative controls. We compared biomarker levels in cases with contemporaneous samples from control patients with upper respiratory symptoms and a negative SARS-CoV-2 PCR test. To assess RAAS biomarker changes during the course of COVID-19 hospitalization, we studied cases at 2 different times points ∼ 12 days apart. We employed age- and sex-adjusted generalized linear models and paired/unpaired t tests.ResultsMean age was 51 years for both cases (31% women) and controls (50% women). ARR was higher in the first sample among hospitalized COVID-19 patients vs controls (P = 0.02). ACE activity was lower among cases at their first sample vs controls (P =

Published
2022

21. Microbiology testing capacity and antimicrobial drug resistance in surgical-site infections: a post-hoc, prospective, secondary analysis of the FALCON randomised trial in seven low-income and middle-income countries

Author

Aboderin, Aaron Oladipo, Amfoabegyi, Solomon, Awopeju, Abimbola Temitayo, Bahrami-Hessari, Michael, Garchie, Emmanuel Isaac Acquah, Gill, Martin, Karikari, Akosua, Kirby, Andrew, Makanjuola, Olufunmilola, Mutiu, Bamidele, Offiong, Anthony Bassey, Oshun, Philip Olayiwola, Osumanu, Hisham Alhassan, Owusu-Ofori, Alex, Varghese, Shereen Rachel, Adam-Zakariah, Leslie Issa, Adebanjo, Ademola Tolulope, Aguirre, Celina Cuellar, Akoto, Erica, Aminu, Aliyu, Armah, Ralph, Aruldas, Neerav David, Choudhrie, Ashish V, Coompson, Christian Larbi, Ekwunife, Okechukwu Hyginus, Fourtounas, Maria, Lawani, Souliath, Mathew, Arpit Jacob, Patel, Akhil, Ademuyiwa, Adesoji O, Hardy, Pollyanna, Runigamugabo, Emmy, Sodonougbo, Pierre, Behanzin, Hulrich, Kangni, Sosthène, Agboton, Gérard, Adagrah, Luke Aniakwo, Adjei-Acquah, Esther, Acquah, Ato Oppong, Ankomah, James, Acquah, Regina, Addo, Kwame Gyambibi, Acheampong, Dorcas Otuo, Adu-Aryee, Nii Armah, Abubakari, Fatao, Titigah, Abraham, Owusu, Frank, Adu-Brobbey, Raphael, Adobea, Vivian, Abantanga, Francis Atindaana, Gautham, Arun, Bhatti, Dimple, Jesudason, Esther Daniel Mark, Aggarwal, Manisha, Alexander, Philip, Dasari, Amos, Alpheus, Rahul, Kumar, Hemanth, Raul, Subrat, Bueno, Wenceslao Ángeles, Ortiz, Reyes Cervantes, Gomez, Isaac Baltazar, Cerdan, Claudia Caballero, Gallo, Mariana Barreto, Gamez, Rozana Reyes, Sánchez, Irani Durán, Abdullahi, Lawal, Adesanya, Opeoluwa, Abdulsalam, Moruf, Adeleye, Victoria, Egwuonwu, Ochomma, Adeleke, Akeem, Adebayo, Francis, Chiejina, Godwin, Abayomi, Olukayode, Abdur-Rahman, Lukman, Ede, Jude, Ezinne, Uba, Kanyarukiko, Salathiel, Dusabe, Moses, Hirwa, Aime Dieudonne, Bucyibaruta, Georges, Adams, Mary Augusta, Birtles, Cheryl, Ally, Zain, Adewunmi, Abdus-sami, Cook, Jonathan, Brown, Julia, Adisa, Adewale O, Ismail, Lawani, Bhangu, Aneel, Omar, Omar, Simoes, Joana FF, Li, Elizabeth, Chaudhry, Daoud, Saeed, Samerah, Spurring, Eleanor Margaret, Verjee, Azmina, Assouto, Pamphile, Seto, Djifid Morel, Kpangon, Cyrile, Ahossi, Rene, Alhassan, Bin Baaba Alhaji, Agyekum, Vera, Assah-Adjei, Frank, Asare, Christopher, Amoako, James, Akosa, Enoch Appiah, Acquaye, Jane, Adjei, Faisal, Ballu, Cletus, Bennin, Amos, Abdulai, Darling Ramatu, Hepzibah, Alice, Bhatti, William, Paul, Priyadarshini K, Dhamija, Parth, Thomas, Josy, Jacob, Priya, Choudhrie, Ashish, Peters, Nitin, Sharma, Rajeev, Camacho, Francisco Barbosa, Gonzalez, Gonzalo Hernandez, Solano, David Dominguez, Flores, Ana Cortes, Menindez, Roque Lincona, Vazquez, Diana Gonzalez, Ado, Khadija, Awonuga, David, Adeniran, Abimbola, Ademuyiwa, Adesoji, Ekwunife, Okechukwu, Adenikinju, Wilson, Aisuodionoe-Shadrach, Oseremen, Edet, Ekpo, Abdus-Salam, Rukiyat, Adeleke, Nurudeen, Ekenze, Sebastian, Francis, Matthew, Mukaneza, Francine, Izabiriza, Emelyne, Kabanda, Elysee, Bunogerane, Gisele Juru, Crawford, Richard, Ivy, Mathete, Jayne, David, Cousens, Simon, Chakrabortee, Sohini, Ghosh, Dhruva, Gyamfi, Frank Enoch, Brant, Felicity, Fiogbe, Michel, Tandje, Yannick, Akpla, Marcelin, Ngabo, Raoul Baderha, Amoako-Boateng, Mabel Pokuah, Agyemang, Eric, Asabre, Esther, Boakye, Anthony Appiah, Gakpetor, Delali Akosua, Appiah, Akosua Dwamena, Boakye, Percy, Adinku, Michael, Barimah, Charles Gyamfi, Labaran, Abdul-Hamid, Dankwah, Fred, Acquah, Daniel Kwesi, Mary, Grace, Bir, Karan, Madankumar, Latha, Gupta, Himani, Zechariah, Pradeep, Kurien, Elizabeth, Vakil, Rakesh, Hernández, Aldo Bernal, Krauss, Rosa Hernandez, Avendaño, Alejandro Cuevas, Garcia, Rafael Toriz, Ojeda, Alejandro Gonzalez, Peón, Alberto Navarrete, Lara, Maria Martínez, Aliyu, Mohammed, Fasiku, Olushola, Ajai, Olalekan, Adeniyi, Oluwafunmilayo, Modekwe, Victor, Adeniyi, Olumide, Akaba, Godwin, Inyang, Akan, Adebayo, Sikiru, Adesola, Muideen, Enemuo, Vincent, Ikechukwu, Iweha, Mukantibaziyaremye, Deborah, Maniraguha, Hope Lydia, Mbonimpaye, Salomee, Habumuremyi, Sosthene, Ede, Chikwendu Jeffrey, Mbavhalelo, Cynthia, Laurberg, Soren, Smart, Neil, de la Medina, Antonio Ramos, Brocklehurst, Peter, Koco, Houenoukpo, Chobli, Hugues Herve, Bisimwa, Nathan, Appiah, Anthony Baffour, Akesseh, Rebecca Adjeibah, Boateng, Ruby Acheampong, Fosu, Godfred, Gawu, Victoria Sena, Aseti, Mark, Agbedinu, Kwabena, Ametefe, Elikem, Boateng, Guy Casskey, Owusu, Junior Atta, Doe, Stanley, Ayingayure, Emmanuel, Singh, Deepak, Daniel, Swati, Mittal, Rohin, Kanna, Vinoth, Mathew, Arpit, Arellano, Ana Bogurin, Miguelena, Luis Hernández, Sansores, Luis Dominguez, Velasco, Monica Jimenez, Muñoz, Maria Paz, Perez-Maldonado, Laura Martinez, Anyanwu, Lofty-John, Ogo, Chidiebere, Akande, Olukemi, Akinajo, Opeyemi, Okoro, Chukwuemeka, Adepiti, Akinfolarin, Ameh, Lazarus, Isa, Mary, Ajao, Akinlabi, Afolabi, Rafiat, Eze, Matthew, Nnyonno, Okoi, Munyaneza, Aphrodis, Mpirimbanyi, Christophe, Mukakomite, Christine, Haragirimana, Jean de Dieu, Moore, Rachel, Metchinhoungbe, Serge, Kovohouande, Blaise, Kandokponou, Covalic Melic Bokossa, Asante-Asamani, Alvin, Amponsah-Manu, Forster, Koomson, Barbara, Serbeh, Godwin, Obbeng, Ambe, Banka, Charles, Gyamfi, Brian, Agbeko, Anita Eseenam, Amoako, Joachim Kwaku, Luri, Prosper Tonwisi, Kantanka, Ruth Sarfo, Osman, Imoro, Dhar, Tapasya, Nagomy, Ida, Kumar, Ashwani, Prakash, Danita, Torres, Edgar Cortes, Romero, Marco Hurtado, Mejia, Hector Ortiz, de la Fuente, Alejandra Nayen Sainz, Magashi, Mahmoud, Atobatele, Kazeem, Akinboyewa, David, Uche, Chisom, Aderounmu, Adewale, Mbajiekwe, Ndubuisi, Iseh, Faith, Amusat, Olanrewaju, Agodirin, Sulaiman, Ezomike, Uchechukwu, Okoro, Philemon, Ndegamiye, Gibert, Mutuyimana, Josiane, Muroruhirwe, Piolette, Imanishimwe, Alphonsine, Hyman, Gabriella, Ntirenganya, Faustin, Sogbo, Hodonou, Dokponou, Mireille, Boakye, Benedict, Ofosu-Akromah, Richard, Kusiwaa, Ataa, Gyan, Kofi Yeboah, Ofosuhene, Doris, Dadzie, Samuel, Kontor, Bismark Effah, Amankwa, Emmanuel Gyimah, Attepor, Godsway Solomon, Kobby, Ephraim, Kunfah, Sheba, Dhiman, Jyoti, Selvakumar, Rajesh, Singh, Gurtaj, Susan, Anju, Orozco, Clotilde Fuentes, del Campo, Laura Urdapilleta Gomez, de la Medina, Antonio Ramos De, Muhammad, Abubakar, Eke, Grace, Alasi, Iyabo, Ugwuanyi, Kenneth, Adesunkanmi, Abdulhafiz, Ogbo, Felix, Marwa, Adams, Ayandipo, Omobolaji, Aremu, Isiaka, Izuka, Emmanuel, Patrick, Igwe, Tubasiime, Ronald, Mwenedata, Olivier, Ingabire, JC Allen, Khan, Zafar, Harrison, Ewen, Tabiri, Stephen, Glasbey, James, Dossou, Francis Moïse, Debrah, Samuel A, Enti, Donald, Twerefour, Emmanuel Yaw, Nyarko, Isaac Omane, Osei-Poku, Dorcas, Essien, Derick, Kyeremeh, Christian, Amoah, Michael, Brown, George Darko, Larnyor, Kennedy Kofi Korankye-Hanson, Limann, Gbana, Shankar, Bharat, Varghese, Rose, de Rojas, Erick González García, Muhammad, Saminu, Faboya, Omolara, Alakaloko, Felix, Ugwunne, Chuka, Adisa, Adewale, Olori, Samson, Ogbeche, Sunday, Egbuchulem, Kelvin, Bello, Jibril, Mbadiwe, Okezie, Raphael, John, Rwagahirima, Elisee, Mukanyange, Violette, Kwati, Morapedi, Dzemta, Corinne, Ganiyu, Rahman Adebisi, Robertson, Zelda, Puozaa, Diana, Manu, Ruth, Amoah, George, Fenu, Benjamin, Osei, Edwin, Mohammed, Shamudeen Alhassan, Goyal, Sunita, Sivakumar, Moonish, Muideen, Bello, Imam, Zainab, Atoyebi, Oluwole, Ajekwu, Samuel, Osagie, Olabisi, Olory, Edima, Ekwuazi, Hyginus, Lawal, Saheed, Mbah, Ngozi, Vaduneme, Oriji, Uwizeyimana, Francine, Munyaneza, Emmanuel, Mathe, Mpho Nosipho, Haque, Parvez D, Gaou, Antoine, Koggoh, Patience, Tackie, Enoch, Hussey, Romeo, Mensah, Elijah, Appiah, Juliana, Kumassah, Philemon Kwame, Owusu, Prince Yeboah, Mohammed, Sheriff, Goyal, Ankush, Sridhar, Rajeevan, Ramírez, Bertha Guzmán, Takai, Idris, Momson, Esther, Balogun, Olanrewaju, Ajenjfuja, Olusegun, Sadiq, Abu, Udie, Gabriel, Elemile, Peter, Lawal, Abdulwahab, Victor, Abhulimen, Zirikana, Job, Mutabazi, Emmanuel, Heritage, Emily, Goudou, Roland, Kpankpari, Richard, Temitope, Arkorful Ebenezer, Kwarteng, Jemima, Solae, Friko Ibrahim, Arthur, Joshua, Olayiwola, David Olatayo, Sie-Broni, Clement Ayum, Musah, Yakubu, Thomas, Cecil, Valadez, Michel Hernández Valadez, Ukata, Onyekachi, Nwaenyi, Francisca, Belie, Orimisan, Akindojutimi, Jerrie, Sani, Samuel, Udosen, Joseph, Lawal, Taiwo, Raji, Hadijat, Ncogoza, Isaie, Nhlabathi, Ncamsile Anthea, Hedefoun, Emmanuel, Opandoh, Isabella Naa M., Sowah, Naa Anyekaa, Toffah, Gideon Kwasi, Ayim, Alex, Wordui, Theodore, Zume, Marshall, Ofori, Bernard, Hans, Monika, Titus, Devabalan, Acevedo, Diego Luna, Ogunyemi, Ayokunle, Bode, Christopher, Akinkuolie, Akinbolaji, Tabuanu, Nancy, Usang, Usang, Lawal, Olatunji, Sayomi, Olayinka, Nxumalo, Hlengiwe Samkelisiwe, Kroese, Karolin, Houtoukpe, Sunday, Manu, Meshach Agyemang, Yeboah, Grace, Ayodeji, Emmanuel Kafui, Agboadoh, Nelson, Owusu, Emmanuel Abem, Haque, Parvez, Galaviz, Rubén Morán, Oludara, Mobolaji, Ekwesianya, Andrew, Alatise, Olusegun, Uanikhoba, Martins, Olagunju, Solomon, Shittu, Asimiyu, Nyirahabimana, Jeannette, Pattinson, Paddy, Lillywhite, Rachel, Lapitan, Carmela, Kamga, Felix, Manu, Maison Patrick Opoku, Yeboah, Cynthia, Boakye-Yiadom, Jonathan, Saba, Abdul-Hafiz, Konda, Samuel, Flores, Oscar Olvera, Omisanjo, Olufunmilade, Elebute, Olumide, Allen, Olubukola, Osuala, Peter, Urimubabo, Christian, Sentholang, Nnosa, Kiki-Migan, Eric, Mensah, Samuel, Boateng, Edward Amoah, Seidu, Anwar Sadat, Luther, Anil, Navarro, José Pérez, Oshodi, Olabode, Ezenwankwo, Francis, Amosu, Lukmon, Suleman, Bamidele, Sethoana, Mmule Evelyn, Lissauer, David, Morna, Martin Tangnaa, Dally, Charles, Mahajan, Amit, Belmontes, Kevin Pintor, Oshodi, Yusuf, Fatuga, Adedeji, Archibong, Micheal, Takure, Augustine, Stassen, Maria Elizabeth, Magill, Laura, Lawani, Ismaïl, Nkrumah, John, Davor, Anthony, Yakubu, Mustapha, Makkar, Shalini, Marbello, Fernando Ramirez, Oyewole, Yemisi, Ihediwa, George, Arowolo, Olukayode, Thornley, Laura, Morton, Dion, Loko, René, Nortey, Michael, Gyasi-Sarpong, Christian Kofi, Yenli, Edwin Mwintiereh Ta-ang, Mandrelle, Kavita, Ramírez-González, Luis, Salami, Omotade, Jimoh, Adesola, Ayantona, Deborah, Wondoh, Paul, Nepogodiev, Dmitri, Mistry, Punam, Moutaïrou, Afissatou, Ofori, Emmanuel Owusu, Hamidu, Naabo Nuhu Noel, Michael, Vishal, Aguirre, Laura Reyes, Williams, Omolara, Kuku, Jubril, Ayinde, Ademola, Monahan, Mark, Ogouyemi, Pencome, Quartson, Elizaberth Mercy Quartson, Haruna, Iddrisu, Mukherjee, Partho, García, Ramona Rojas, Ladipo-Ajayi, Oluwaseun, Badejoko, Olusegun, Soumanou, Fouad, Kwarley, Naa, Rajappa, Reuben, Robles, Eduardo Valtierra, Makanjuola, Ayomide, Badmus, Tajudeen, Smith, Donna, Tamadaho, Pia, Lovi, Agbenya Kobla, Singh, Prashant, Mokwenyei, Olayanju, Etonyeaku, Amarachukwu, Zounon, Mack-Arthur, Nimako, Boateng, Suroy, Atul, Nwokocha, Samuel, Igbodike, Emeka, Nyadu, Bertina Beauty, Thind, Ravinder, Ogein, Olubunmi, Ijarotimi, Omotade, Opoku, Dominic, Thomas, Alen, Ojewola, Rufus, Lawal, Adedayo, Pinkney, Thomas, Osabutey, Anita, Tuli, Arti, Oladimeji, Abraham, Nana, Fayowole, Roberts, Tracy, Sagoe, Robert, Veetil, Sreejith, Olajide, Thomas, Oduanafolabi, Tunde, Tuffour, Samuel, Oluseye, Oluwaseun, Olasehinde, Olalekan, Tufour, Yaa, Seyi-Olajide, Justina, Olayemi, Olaniyi, Winkles, Neil, Yamoah, Francis Akwaw, Soibi-Harry, Adaiah, Omitinde, Stephen, Yefieye, Abiboye Cheduko, Ugwu, Aloy, Oni, Owolabi, Yorke, Joseph, Williams, Emmanuel, Onyeze, Chigozie, Orji, Ernest, Rotimi, Adewale, Salako, Abdulkadir, Solaja, Olufemi, Sowemimo, Oluwaseun, Talabi, Ademola, Tajudeen, Mohammed, and Wuraola, Funmilola

Published
2024
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22. Sexual health risk indicators and their associations with caries status and gingival health of adolescents resident in sub-urban South-West Nigeria [version 2; peer review: 1 approved, 2 approved with reservations]

Author

Morenike Oluwatoyin Folayan, Maha El Tantawi, Olaniyi Arowolo, Randa Yassin, and Nadia A. Sam-Agudu

Subjects
Adolescents, Risk-taking, Sexual health, Oral Health, Nigeria, eng, Science, Social Sciences
Abstract

Background Adolescents are at high risk of poor sexual and oral health. We investigated for sexual risk factors associated with caries experience and gingival health among adolescents in Nigeria. Methods This cross-sectional study collected data from 10-19-year-old adolescents in Ile-Ife, South-West Nigeria through a household survey conducted between December 2018 and January 2019. Information collected included age; sex; socioeconomic status; sexual practices (vaginal, oral, anal sex); sexual (transactional sex, multiple sex partners, condom use at last sexual intercourse) and oral health (frequency of tooth brushing, use of fluoridated toothpaste, dental service utilization in the last 12 months, consumption of refined carbohydrates in-between meals) risk behaviors; caries experience; and gingival health. Logistic regression was used to determine associations between explanatory variables (sexual and oral health risk behaviors) and outcome variables (caries experience and gingivitis). Results There were no significant associations between caries experience and history of sexual intercourse (OR:1.00); condom use at last sex act (OR:0.68); and having one (OR:2.27) or more sexual partners. Also, there was no significant association between moderate/severe gingivitis and a history of anal (OR:2.96), oral (OR:2.69), or vaginal (OR:1.40) sex; and a report of having one (OR:1.71) or more (OR:2.57) sex partners. Conclusions Some sexual health risk indicators insignificantly increase the risk for caries and moderate/severe gingivitis. Screening for sexual risk behaviors during dental care may be a suitable wellness programs approach for adolescents.

Published
2024
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25. Androgenetic alopecia: An updateCapsule Summary

Author

Sincengile Ntshingila, PhD, Ogheneochuko Oputu, PhD, Afolake T. Arowolo, PhD, and Nonhlanhla P. Khumalo, FCDerm, PhD

Subjects
AGA, androgenetic alopecia, cyproterone, female pattern baldness, finasteride, flutamide hair follicle transplantation, Dermatology, RL1-803
Abstract

Androgenetic alopecia (AGA) is the most common nonscarring alopecia and is characterised by distinct gradual patterned hair loss. AGA is mediated by genetic predisposition and excessive follicular sensitivity to androgens, mainly in males, leading to the progressive conversion of scalp terminal hair into vellus hair. Although highly prevalent, it is not fatal but may have a severe psychosocial impact, especially on females and younger males. Significant advances have been made in understanding AGA's epidemiology and pathophysiology, but only 2 drugs remain approved by the FDA - finasteride and minoxidil. Prolonged use of these drugs, is a prerequisite for enhanced treatment response. However, this leads to poor medication adherence and adverse effects from extended use eg, the “postfinasteride syndrome” which persists beyond stopping the drug. Hence, there is a need for research on more effective alternative treatments for AGA, with fewer side effects.This paper reviewed recent advances in AGA pathophysiology and its treatment options. The recently characterized structure of type 2, 5-alpha reductase holds significance in comprehending present and prospective treatments of AGA.

Published
2023
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26. Levels of toxic and trace metals in the breast milk of lactating mothers in Abeokuta, Ogun State, Nigeria

Author

Olanrewaju Olujimi, Sulaimon Ajakore, Damilola Abuganloye, Toyin Arowolo, Oliver Steiner, Walter Goessler, and Taofeek Towolawi

Subjects
Human breast milk, Metal exposure, ICP-MS, Allergic reactions, Dysfunction, Pollution, Toxicology. Poisons, RA1190-1270
Abstract

Background and objectives: Breast milk is an essential source of nutrients and energy for infants. The study analyzed for the levels of essential, toxic and rare earth elements in the breast milk of lactating mothers within Abeokuta metropolis. Materials and methods: Thirty-seven (37) breast milk samples were collected with consents of lactating mothers at Ogun State General Hospital in Abeokuta. The samples were digested using standard method and analyzed for essential, toxic and rare earth elements using Inductively Coupled Plasma Mass Spectrometer (ICP-MS). The data were subjected to descriptive analysis. Results: The results showed higher concentrations of toxic elements than essential elements in the breast milk of lactating mothers, where five toxic metals: Ag, Ti, V, Pb and Ba were observed to be present in 11, 14, 15, 17 and 23 breast milk samples respectively. Two essential (P and S) and two toxic (Cd and Hg (except sample 19)) elements were observed to be present in all the breast milk samples. Rare Earth Elements (except Sr, U and Rb) were below the detection limit of the instrument. Though three breast milk samples (12, 14 and 17) were observed safe, they contained two toxic (Cd and Hg) and a rare earth trace (Rb) element. Conclusion: It could be concluded that despite the inherent benefits of human breast milk with essential elements to the infants, it can still be a source of toxic and trace earth metals contamination.

Published
2023
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28. A Machine Learning-Based Model for Energy Efficiency Classification of an Unmanned Aerial Vehicle

Author

Awotunde, Joseph Bamidele, Arowolo, Micheal Olaolu, Imoize, Agbotiname Lucky, Farhaoui, Yousef, Adeniyi, Abidemi Emmanuel, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Farhaoui, Yousef, editor, Rocha, Alvaro, editor, Brahmia, Zouhaier, editor, and Bhushab, Bharat, editor

Published
2023
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29. Development of a Chi-Square Approach for Classifying Ischemic Stroke Prediction

Author

Arowolo, Micheal Olaolu, Akubor, Victor Ashem, Misra, Sanjay, Garg, Lalit, Adebiyi, Marion Olubunmi, Awotunde, Joseph Bamidele, Kacprzyk, Janusz, Series Editor, Gomide, Fernando, Advisory Editor, Kaynak, Okyay, Advisory Editor, Liu, Derong, Advisory Editor, Pedrycz, Witold, Advisory Editor, Polycarpou, Marios M., Advisory Editor, Rudas, Imre J., Advisory Editor, Wang, Jun, Advisory Editor, Garg, Lalit, editor, Sisodia, Dilip Singh, editor, Kesswani, Nishtha, editor, Vella, Joseph G, editor, Brigui, Imene, editor, Xuereb, Peter, editor, Misra, Sanjay, editor, and Singh, Deepak, editor

Published
2023
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36. Financial Capability and Financial Well-Being Challenges and Vulnerabilities of Adults Living With Acquired Brain Injury: A Pilot Survey

Author

Lisa Engel, PhD, Roheema Ewesesan, MPH, Ibiyemi Arowolo, PhD, Celine Latulipe, PhD, Jane Karpa, PhD, and Mohammad N. Khan, PhD

Subjects
Brain injuries, Economics, Financial management, Financial stress, Rehabilitation, Socioeconomic factors, Medicine (General), R5-920
Abstract

Objective: To describe the financial capability (FC) and financial well-being (FWB) of adults living with acquired brain injury (ABI) from a lived experience perspective. Design: People living with ABI completed a 32-item and close others a 22-item anonymous survey using either online or print/mail-in options. Setting: Responses were collected from adults in the province of Manitoba (Canada) during August-October 2021. Participants: Respondents were adults (18+) living with ABI (n=38) or close others of ABI survivors (n=19). Adults living with ABI experienced traumatic brain injury (n=22; 58%), stroke (n=8; 21%), or other ABI mechanisms (n=8; 21%). Nineteen (50%) respondents with ABI were men, 17 (45%) were women, and 1 (2.5%) was nonbinary; 95% were more than 1-year post-ABI. Close others were spouses/partners, parents, other family, and paid caregivers. Three of the 19 close others self-reported as men and 16 as women. Interventions: n/a. Main Outcome Measure(s): n/a. Results: For key FC indicators, 13 (34%) people living with ABI felt their current knowledge and skills were insufficient, and 26 (70%) felt that ABI had affected their ability to make financial decisions or complete financial activities. Fourteen of the 19 close others have worried about the finance-related choices, skills, or behaviors of the person living with ABI, and 17 felt that ABI symptoms had affected the FC of the person living with ABI. For key FWB indicators, 22 (58%) adults living with ABI felt stressed or anxious about finances at least some of the time. Seventeen (45%) of the adults living with ABI reported having trouble making ends meet at least some of the time. Conclusions: Respondents reported FC limitations and FWB challenges for people living with ABI, which can be indicative of financial vulnerabilities and unmet needs. Future research should explore optimal ways to address these financial-related challenges after ABI.

Published
2024
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37. Governance of automated vehicle in the urban transport system: Insight from a willingness-to-use survey and Norwegian cultural context

Author

Wale Arowolo, Magnus Larsson, and Isabelle Nicolaï

Subjects
AV, Governance, Informal institution, Willingness-to-use, Urban transport system, Transportation and communications, HE1-9990
Abstract

Automated vehicles (AV) can increase safety, reduce congestion, and provide environmental benefits to the urban transport system. Nonetheless, AV’s governance in the urban transport system is challenging. This paper proposes a novel interdisciplinary methodology and contributes to the governance debate from the ‘policy’ and ‘polity’ dimensions. We attempt to draw insight from the Norwegian cultural context and a willingness to use AV survey in Oslo, Norway. We then attempt to provide insight into the workable governance approach for AV deployment in the Oslo region, Norway. Our result suggests that less than half of the people in the Oslo region are willing to use AV. Based on our analytical insight, we argue that a workable governance approach for AV that will allay fears of privacy loss while making people feel safe and secure, manage uncertainty, pessimism about technological innovation, and embrace time-honoured Norwegian traditions should be considered to support the deployment of AV in Norway.

Published
2024
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39. Phishing Detection in Blockchain Transaction Networks Using Ensemble Learning

Author

Roseline Oluwaseun Ogundokun, Micheal Olaolu Arowolo, Robertas Damaševičius, and Sanjay Misra

Subjects
blockchain, network security, phishing, attack recognition, deep learning, Computer engineering. Computer hardware, TK7885-7895, Electronic computers. Computer science, QA75.5-76.95
Abstract

The recent progress in blockchain and wireless communication infrastructures has paved the way for creating blockchain-based systems that protect data integrity and enable secure information sharing. Despite these advancements, concerns regarding security and privacy continue to impede the widespread adoption of blockchain technology, especially when sharing sensitive data. Specific security attacks against blockchains, such as data poisoning attacks, privacy leaks, and a single point of failure, must be addressed to develop efficient blockchain-supported IT infrastructures. This study proposes the use of deep learning methods, including Long Short-Term Memory (LSTM), Bi-directional LSTM (Bi-LSTM), and convolutional neural network LSTM (CNN-LSTM), to detect phishing attacks in a blockchain transaction network. These methods were evaluated on a dataset comprising malicious and benign addresses from the Ethereum blockchain dark list and whitelist dataset, and the results showed an accuracy of 99.72%.

Published
2023
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48. Exploring the Development of a User-Friendly Home Management System with ESP Rainmaker Firmware

Author

Matthew Oluwole Arowolo, Adekunle Okikioluwa Owolabi, Henry Onaopemipo, Bankole-Ajayi, and Oluwaseyi Paul Akinyele

Subjects
Home, Automation, ESP rainmaker, System, Device, Firmware, Engineering (General). Civil engineering (General), TA1-2040
Abstract

With the rapid development of the Internet of Things (IoT), managing living spaces has become more intuitive than ever. This research illustrates the implementation of a user-friendly home management system utilizing the advanced ESP Rainmaker firmware from Espressif Systems. The study focuses on creating a seamless user experience through the efficient integration of ESP Rainmaker's features. Various hardware components are carefully selected to facilitate the creation of user-friendly smart devices, including intelligent lighting systems, switches, and climate control units. The specialized firmware tailored to the unique attributes of each device ensures secure connections with the ESP Rainmaker cloud services. The research delves into comprehensive provisioning techniques, including Bluetooth and SoftAP, to simplify device onboarding and ensure secure connectivity. Leveraging the Rainmaker cloud services, the system emphasizes the enhanced user control and synchronization of device states, contributing to an average success rate of 88% and an average response time of 2.1 seconds. This study provides valuable insights into the development of intuitive and secure home automation systems, underscoring the significance of integrated platforms like ESP Rainmaker in shaping the future of IoT-enabled living environments.

Published
2023
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49. Assessment of Physical and Chemical Characteristics of Jebba Upper Basin on River Niger, North Central Nigeria

Author

K. M. Adelakun, A. A. Idowu, W. O. Alegbeleye, T. A. Arowolo, and A. O. Akinde

Subjects
Human activities, pollution, spatio-temporal, water quality, physicochemical characteristics, Science
Abstract

Jebba Upper Basin upstream at Kainji, was constructed on River Niger in Nigeria during the last five decades mainly for hydropower generation, but receives pollutants through anthropogenic activities. This study assesses physical and chemical characteristics of Jebba upper basin on River Niger, North Central Nigeria using appropriate standard methods. The results show that the mean values of the physical and chemical parameters of water were: temperature (27.89±1.84 °C), pH (7.17±0.22), dissolved oxygen (6.35±0.91 mg/L), total hardness (42.33±32.89 mg/L), biological oxygen demand (2.85±1.07 mg/L), and conductivity (51.13±29.09 µs/cm). The result shows that temperature has significant positive (either at r < 0.05 and r < 0.01) association with Total Hardness (TH) (0.47), BOD (0.30) and NO3- (0.43) though inversely correlated with transparency (-0.29, r >0.05). Total Hardness also have a positive correlation (0.52, r >0.05) with nitrate. Spatial-temporal variations influenced by environmental factors were observed to impacted water quality parameters in the study area.

Published
2023
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50. Development of a Mobile App for Inverter System Management

Author

Matthew Oluwole Arowolo, Emmanuel Akinyemi Oyetade, Oluwaseun Samuel Agboola, and Oluwatosin Steven George

Subjects
ESP32 Microcontroller, Inverter systems, Mobile application, Remote monitoring, Renewable energy, Engineering (General). Civil engineering (General), TA1-2040
Abstract

In many developing nations, inconsistent power supply has led to a reliance on generators for residential energy needs, resulting in increased noise and air pollution. In response, the adoption of inverters has gained prominence as a cleaner and safer alternative. However, the lack of remote monitoring and control capabilities has limited the widespread application of traditional inverters. While previous research efforts have focused on mobile app development for inverter systems, the observed limitations in accuracy, precision, and response time have prompted the need for further advancements. This study addresses these challenges through the development of a mobile app for precise inverter system control and monitoring, leveraging the Blynk app's remote-control features. The user-friendly interface of the application enhances accessibility and usability. A specialized control device, integrated with the inverter system, utilizes the ESP32 microcontroller for efficient and low-power operation. Performance evaluation of the developed system yielded an impressive 94.15% accuracy and an optimal precision of 0.98%. The recorded average response time of 1.2 seconds highlights the system's efficient and prompt responsiveness. These findings demonstrate the suitability of the developed mobile application for robust monitoring and control of inverter systems. Furthermore, the identified scope for improvement includes enhancing the response time using 5G networks and ensuring the system's compatibility with evolving technological standards.

Published
2023
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