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Background: Neoadjuvant chemotherapy (NAC) is an integral component of T4 breast cancer (BCa) treatment. We compared response to NAC for T4 BCa in the U.S. and Nigeria to direct future interventions., Materials and Methods: Cross-sectional retrospective analysis included all patients with non-metastatic T4 BCa treated from 2010 to 2016 at Memorial Sloan Kettering Cancer Center (New York, New York) and Obafemi Awolowo University Teaching Hospitals Complex (Ile Ife, Nigeria). Pathologic complete response (pCR) and survival were compared and factors contributing to disparities evaluated., Results: Three hundred and eight patients met inclusion criteria: 157 (51%) in the U.S. and 151 (49%) in Nigeria. All U.S. patients received NAC and surgery compared with 93 (62%) Nigerian patients. Fifty-six out of ninety-three (60%) Nigerian patients completed their prescribed course of NAC. In Nigeria, older age and higher socioeconomic status were associated with treatment receipt. Fewer patients in Nigeria had immunohistochemistry performed (100% U.S. vs. 18% Nigeria). Of those with available receptor subtype, 18% (28/157) of U.S. patients were triple negative versus 39% (9/23) of Nigerian patients. Overall pCR was seen in 27% (42/155) of U.S. patients and 5% (4/76) of Nigerian patients. Five-year survival was significantly shorter in Nigeria versus the U.S. (61% vs. 72%). However, among the subset of patients who received multimodality therapy, including NAC and surgery with curative intent, 5-year survival (67% vs. 72%) and 5-year recurrence-free survival (48% vs. 61%) did not significantly differ between countries., Conclusion: Addressing health system, socioeconomic, and psychosocial barriers is necessary for administration of complete NAC to improve BCa outcomes in Nigeria., Implications for Practice: This cross-sectional retrospective analysis of patients with T4 breast cancer in Nigeria and the U.S. found a significant difference in pathologic complete response to neoadjuvant chemotherapy (5% Nigeria vs. 27% U.S.). Five-year survival was shorter in Nigeria, but in patients receiving multimodality treatment, including neoadjuvant chemotherapy and surgery with curative intent, 5-year overall and recurrence-free survival did not differ between countries. Capacity-building efforts in Nigeria should focus on access to pathology services to direct systemic therapy and promoting receipt of complete chemotherapy to improve outcomes., (© 2021 AlphaMed Press.)

Humans have increasingly intervened in the nature to advance socioeconomic development at the expense of ecosystem services. Tradeoffs between ecosystem services and socioeconomic development are inevitable and should be considered in sustainable ecosystem management. This is no exception in Zhangye where intensive agricultural activities have significantly affected its ecological conditions. Thus, this study evaluated the tradeoffs between agricultural production and key ecosystem services along with their spatial distributions at the watershed level in Zhangye based on multisource observation data. The key ecosystem services, including net primary productivity (NPP), water yield, and soil conservation, were evaluated for the years 2000, 2010, and 2015 using remote sensing data and the InVEST model. The Morishima elasticity of substitution (MES) between these ecosystem services and agricultural production were then estimated by applying a quadratic directional output distance function, and mapped to determine the tradeoffs. The results showed that the average NPP and annual water yield respectively increased by 22% and 24%, while annual soil conservation decreased by 22% during 2000-2015. The average MES values for agricultural production with NPP, water yield, and soil conservation were 0.14, -0.69, and -0.56, respectively. This indicated the existence of a synergetic relationship between agricultural production and NPP as well as tradeoff relationships between agricultural production and water yield/soil conservation. Differences in the spatial patterns of the relationships between agricultural production and these ecosystem services were observed. Significant tradeoff relationships were observed for agricultural production with water yield and soil conservation in the upper reach of Zhangye. It indicated that increasing agricultural production would be at the cost of decreased water yield and soil conservation, especially in the upper reach area. The quantification and spatial pattern determinations of tradeoffs between ecosystem services and agricultural production is useful for the development of regional ecological conservation policy and sustainable ecosystem management., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Increasing human activities worldwide have significantly altered the natural ecosystems and consequently, the services they provide. This is no exception in Nigeria, where land-use/land-cover has undergone a series of dramatic changes over the years mainly due to the ever-growing large population. However, estimating the impact of such changes on a wide range of ecosystem services is seldom attempted. Thus, on the basis of GlobeLand30 land-cover maps for 2000 and 2010 and using the value transfer methodology, we evaluated changes in the value of ecosystem services in response to land-use/land-cover dynamics in Nigeria. The results showed that over the 10-year period, cultivated land sprawl over the forests and savannahs was predominant, and occurred mainly in the northern region of the country. During this period, we calculated an increase in the total ecosystem services value (ESV) in Nigeria from 665.93 billion (2007 US$) in 2000 to 667.44 billion (2007 US$) in 2010, 97.38% of which was contributed by cultivated land. The value of provisioning services increased while regulation, support, recreation and culture services decreased, amongst which, water regulation (-11.01%), gas regulation (-7.13%), cultural (-4.84%) and climate regulation (-4.3%) ecosystem functions are estimated as the most impacted. The increase in the total ESV in Nigeria associated with the huge increase in ecosystem services due to cultivated land expansion may make land-use changes (i.e. the ever-increasing agricultural expansion in Nigeria) appear economically profitable. However, continuous loss of services such as climate and water regulation that are largely provided by the natural ecosystems can result in huge economic losses that may exceed the apparent gains from cultivated land development. Therefore, we advocate that the conservation of the natural ecosystem should be a priority in future land-use management in Nigeria, a country highly vulnerable to climate change and incessantly impacted by natural disasters such as flooding., (Copyright © 2018 Elsevier B.V. All rights reserved.)

Curing, though important is sometimes underrated in concrete production. This dataset provided shows the effects of four (4) different methods of curing on two distinct mix ratios. The data provided in this article are for a study that was conducted on one hundred and sixty (160) cube samples of mix ratios 1:2:4 and 1:1.5:3 while employing four (4) different methods of curing. The data given in the article displays the finding of the study. The findings can aid in prediction and optimization of concrete behavior and compressive strength when any of the curing methods are utilized.

Background: Colonoscopy is useful for diagnosis, treatment and surveillance of anal and colorectal lesions. It affords a good, less invasive and tolerable way to see and access the large intestine., Aim and Objective: To determine the indications, finding and diagnosis at colonoscopy in a riverine setting in Southwestern Nigeria., Type of Study: Descriptive cross sectional study., Patients and Methods: Patients who presented in the State Specialist Hospital, Okitipupa and requiring colonoscopy in their management between January 2011 to April 2013 were included in this study. They were reviewed and their demographic and clinical data, indications for colonoscopy, the findings and the pathological diagnosis were entered in a proforma., Results: Colonoscopy was done in 100 patients out of which seventy seven (77%) were males and 23 (23%) were females. The indications were frank lower gastrointestinal bleeding 55 (55%) chronic diarrhea (11%), chronic constipation10(10%), occult gastrointestinal bleeding (7.0%), lower abdominal and anal pain 4 (4.0%), queried anorectal cancer 3 (3.0%) and enterocutaneous fistula 1(1%). Colonoscopic findings, include, normal finding 24(24%) colitis 24 (24.0%), hemorrhoid 20(20.0%), Anal fissure 16 (16.0%) colonic cancer 5 (5.0%), anorectal cancer 4 (4.0%), caecal cancer 2 (2.0%) faecal impaction 2 (2.0%), anal wart 2 (2.0%) , polyps 1 (1.0%) and anal fistula 1 (1.0%). The diagnostic yield was 76%., Conclusion: Bleeding from the lower gastrointestinal tract was the commonest indication for colonoscopy and the most frequent pathology was amoebic in the riverine Southwestern Nigeria.