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4. High-Flow Nasal Cannula System in Respiratory Failure Associated with Interstitial Lung Diseases: A Systematic Review and Narrative Synthesis.

Author

Pagliaro, Raffaella, Aronne, Luigi, Fomez, Ramona, Ferri, Vincenzo, Montella, Antonia, Sanduzzi Zamparelli, Stefano, Bianco, Andrea, and Perrotta, Fabio

Subjects
*NASAL cannula, *RESPIRATORY organs, *RESPIRATORY insufficiency, *SYSTEM failures, *ADULT respiratory distress syndrome, *BUTORPHANOL
Abstract

Background: High-flow nasal cannula (HFNC) therapy has emerged as a promising treatment modality for interstitial lung disease (ILD)-related respiratory failure. This systematic review aims to evaluate the efficacy and safety of HFNC therapy in patients with ILDs. Methods: A comprehensive literature search was conducted using major electronic databases to identify relevant studies investigating the use of HFNC therapy in ILD patients with respiratory failure. Outcome measures of interest included improvements in oxygenation, dyspnea relief, respiratory rate control, hospital length of stay, and mortality. Results: Twelve studies were analyzed with an overall population of 715 patients included. Idiopathic Pulmonary Fibrosis (IPF) was the most prevalent type of ILD. Evaluated clinical settings were acute (7 studies), chronic (2 studies), and end-stage (3 studies) ILDs. The HFNC as a support for acute respiratory failure seems not inferior to non-invasive ventilation while offering better comfort and patient's perception. Poor data are available about use in chronic/long-term or rehabilitative settings. In end of life/palliative care, an HFNC might improve quality of life. Despite the promising results, further research is warranted to establish optimal HFNC protocols, identify patient subgroups most likely to benefit, and explore long-term outcomes. Conclusions: Overall, the HFNC appears to be a valuable therapeutic option for managing respiratory failure in ILD patients, offering potential improvements in oxygenation and symptom relief. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt?

Author

Mariniello, Domenica Francesca, primary, Allocca, Valentino, additional, D’Agnano, Vito, additional, Villaro, Riccardo, additional, Lanata, Luigi, additional, Bagnasco, Michela, additional, Aronne, Luigi, additional, Bianco, Andrea, additional, and Perrotta, Fabio, additional

Published
2022
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7. Moving Immune Checkpoint Inhibitors to Early Non-Small Cell Lung Cancer: A Narrative Review

Author

Viscardi, Giuseppe, primary, Vitiello, Fabiana, additional, Servetto, Alberto, additional, Gristina, Valerio, additional, Pizzutilo, Elio Gregory, additional, Canciello, Maria Anna, additional, Medusa, Paola Maria, additional, Salomone, Fabio, additional, Di Guida, Gaetano, additional, Mollica, Mariano, additional, Aronne, Luigi, additional, Scaramuzzi, Roberto, additional, Napolitano, Filomena, additional, Battiloro, Ciro, additional, Caputo, Francesca, additional, Gilli, Marina, additional, Totaro, Giuseppe, additional, Curcio, Carlo, additional, Rocco, Danilo, additional, and Montesarchio, Vincenzo, additional

Published
2022
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8. Which impact for proton pump inhibitors in SARS-COV-2 pneumonia

Author

Mazzeo, Grazia, primary, Aronne, Luigi, additional, Mariniello, Domenica Francesca, additional, Allocca, Valentino, additional, Palma, Maria Ilaria, additional, Cerqua, Francesco Saverio, additional, Iadevaia, Carlo, additional, Costigliola, Adriano, additional, Parrella, Roberto, additional, Bianco, Andrea, additional, and COVID Group, Vanvitelli/Monaldi, additional

Published
2021
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9. Non-small cell lung cancer presenting as 'psoas muscle syndrome': A case report

Author

Mollica, Mariano, Maffucci, Rosalba, Lavoretano, Sabrina, Rea, Gaetano, Cerqua, Francesco Saverio, Aronne, Luigi, Bianco, Andrea, Perrotta, Fabio, Mollica, Mariano, Maffucci, Rosalba, Lavoretano, Sabrina, Rea, Gaetano, Cerqua, Francesco Saverio, Aronne, Luigi, Bianco, Andrea, and Perrotta, Fabio

Subjects
Psoas muscle syndrome, Skeletal muscles metastases, NSCLC, Skeletal muscles metastase
Abstract

Lung cancer is the leading cause of cancer-related death worldwide and majority of patients are diagnosed in advanced/metastatic disease stage. Sites of distant metastases mainly include contralateral lung, lymph nodes, brain, bones, adrenal glands and liver; skeletal muscles metastases (SMMs) are less common. Psoas muscle and diaphragm metastases are mainly found during autopsy, as their involvement commonly is asymptomatic. We report a case of a 60-year-old female, suffering from non-small cell lung cancer (NSCLC), with refractory lower back pain, as expression of malignant psoas syndrome (MPS). MPS is a rare and difficult-to-treat cancer-pain syndrome, unresponsive to majority of analgesic therapy, related to psoas muscle metastasis; it is usually caused by different tumors such as uterus, ovary, bladder, prostate, colon-rectum, lymphoma, melanoma and sarcoma and represents an uncommon finding in NSCLC patients.

Published
2019

10. Remarkable vessel enlargement within lung consolidation in COVID-19 compared to AH1N1 pneumonia: A retrospective study in Italy

Author

Bianco, Andrea, primary, Valente, Tullio, additional, Perrotta, Fabio, additional, Stellato, Elvira, additional, Brunese, Luca, additional, Wood, Brad J., additional, Carrafiello, Gianpaolo, additional, Parrella, Roberto, additional, Aronne, Luigi, additional, Boccia, Matilde, additional, Lassandro, Francesco, additional, Lassandro, Giulia, additional, Rea, Gaetano, additional, and Scialò, Filippo, additional

Published
2021
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11. Elderly with COPD: comoborbitidies and systemic consequences

Author

Mollica, Mariano, primary, Aronne, Luigi, additional, Paoli, Giorgio, additional, Flora, Martina, additional, Mazzeo, Grazia, additional, Tartaglione, Stefania, additional, Polito, Rita, additional, Tranfa, Carmelindo, additional, Ceparano, Maria, additional, Komici, Klara, additional, Mazzarella, Gennaro, additional, and Iadevaia, Carlo, additional

Published
2020
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14. Nutcracker syndrome

Author

Natale, Francesco, Granato, Chiara, Aronne, Luigi, Di Marco, Giovanni M., Priore, Emanuela Lo, Mocerino, Rosa, Cirillo, Chiara, Calabrò, Paolo, Golino, Paolo, Russo, Maria G., and Calabrò, Raffaele

Published
2009

17. A new character on the scene of cardiorenal syndrome

Author

Natale, Francesco, primary, Lo Priore, Emanuela, additional, Aronne, Luigi, additional, Siciliano, Alessandro, additional, Credendino, Maria, additional, Cirillo, Chiara, additional, Granato, Chiara, additional, Calabrò, Paolo, additional, Russo, Maria Giovanna, additional, and Calabrò, Raffaele, additional

Published
2011
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18. Which is the correct management of patients with asymptomatic severe calcific aortic stenosis after symptomatic spontaneous calcium cerebral embolism?

Author

Natale, Francesco, primary, Aronne, Luigi, additional, Credendino, Maria, additional, Siciliano, Alessandro, additional, Allocca, Filomena, additional, Weizs, Sara Hana, additional, Martone, Francesca, additional, Marco, Giovanni Maria di, additional, Calabrò, Paolo, additional, Tedesco, Michele Adolfo, additional, Russo, Maria Giovanna, additional, and Calabrò, Raffaele, additional

Published
2011
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22. When chewing gum is more than just a bad habit

Author

Natale, Francesco, primary, Cirillo, Chiara, additional, Di Marco, Giovanni Maria, additional, di Vetta, Lucia Scotto, additional, Aronne, Luigi, additional, Siciliano, Alessandro, additional, Mocerino, Rosa, additional, Tedesco, Michele A, additional, Golino, Paolo, additional, and Calabrò, Raffaele, additional

Published
2009
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24. Moving Immune Checkpoint Inhibitors to Early Non-Small Cell Lung Cancer: A Narrative Review

Author

Giuseppe Viscardi, Fabiana Vitiello, Alberto Servetto, Valerio Gristina, Elio Gregory Pizzutilo, Maria Anna Canciello, Paola Maria Medusa, Fabio Salomone, Gaetano Di Guida, Mariano Mollica, Luigi Aronne, Roberto Scaramuzzi, Filomena Napolitano, Ciro Battiloro, Francesca Caputo, Marina Gilli, Giuseppe Totaro, Carlo Curcio, Danilo Rocco, Vincenzo Montesarchio, Viscardi, Giuseppe, Vitiello, Fabiana, Servetto, Alberto, Gristina, Valerio, Pizzutilo, Elio Gregory, Canciello, Maria Anna, Medusa, Paola Maria, Salomone, Fabio, Di Guida, Gaetano, Mollica, Mariano, Aronne, Luigi, Scaramuzzi, Roberto, Napolitano, Filomena, Battiloro, Ciro, Caputo, Francesca, Gilli, Marina, Totaro, Giuseppe, Curcio, Carlo, Rocco, Danilo, Montesarchio, Vincenzo, Gregory Pizzutilo, Elio, Anna Canciello, Maria, and Maria Medusa, Paola

Subjects
immune checkpoint inhibitors, Cancer Research, lung cancer, non-small-cell lung carcinoma (NSCLC), Oncology, adjuvant, Settore MED/06 - Oncologia Medica, neoadjuvant, immunotherapy, immune checkpoint inhibitor
Abstract

Simple Summary Moving from the achievements of immune checkpoint inhibitors in metastatic lung cancer, the great promise of immunotherapy in resectable early-stage is to make a disease, often lethal until now for frequent post-surgery relapses, more curable. This review focuses on role of immunotherapy in early-stage non-small cell lung cancer. We summarize biological rationale, findings from clinical trials of adjuvant and neoadjuvant immune checkpoint inhibitors, questions about biomarkers and choice of endpoints, aiming to provide up-to-date information useful for clinical decision making. Lung cancer is the leading cause of cancer-related death worldwide. Since prognosis of early-stage non-small cell lung cancer (NSCLC) remains dismal for common relapses after curative surgery, considerable efforts are currently focused on bringing immunotherapy into neoadjuvant and adjuvant settings. Previously, perioperative chemotherapy showed only a modest but significative improvement in overall survival. The presence of broad tumor neoantigens load at primary tumor prior to surgery as well as the known immunosuppressive status following resection represent the main rationale for immunotherapy in early disease. Several trials have been conducted in recent years, leading to atezolizumab and nivolumab approval in the adjuvant and neoadjuvant setting, respectively, and perioperative immunotherapy in NSCLC remains a field of active clinical and preclinical investigation. Unanswered questions in perioperative therapy in NSCLC include the optimal sequence and timing of chemotherapy and immunotherapy, the potential of combination strategies, the role of predictive biomarkers for patient selection and the choice of useful endpoints in clinical investigation.

Published
2022

25. Strategies Tackling Viral Replication and Inflammatory Pathways as Early Pharmacological Treatment for SARS-CoV-2 Infection: Any Potential Role for Ketoprofen Lysine Salt?

Author

Domenica Francesca Mariniello, Valentino Allocca, Vito D’Agnano, Riccardo Villaro, Luigi Lanata, Michela Bagnasco, Luigi Aronne, Andrea Bianco, Fabio Perrotta, Mariniello, Domenica Francesca, Allocca, Valentino, D'Agnano, Vito, Villaro, Riccardo, Lanata, Luigi, Bagnasco, Michela, Aronne, Luigi, Bianco, Andrea, and Perrotta, Fabio

Subjects
ketoprofen, SARS-CoV-2, inflammation, Chemistry (miscellaneous), Organic Chemistry, Drug Discovery, COVID-19, Molecular Medicine, Pharmaceutical Science, Physical and Theoretical Chemistry, NSAID, Analytical Chemistry
Abstract

COVID-19 is an infective disease resulting in widespread respiratory and non-respiratory symptoms prompted by SARS-CoV-2 infection. Interaction between SARS-CoV-2 and host cell receptors prompts activation of pro-inflammatory pathways which are involved in epithelial and endothelial damage mechanisms even after viral clearance. Since inflammation has been recognized as a critical step in COVID-19, anti-inflammatory therapies, including both steroids and non-steroids as well as cytokine inhibitors, have been proposed. Early treatment of COVID-19 has the potential to affect the clinical course of the disease regardless of underlying comorbid conditions. Non-steroidal anti-inflammatory drugs (NSAIDs), which are widely used for symptomatic relief of upper airway infections, became the mainstay of early phase treatment of COVID-19. In this review, we discuss the current evidence for using NSAIDs in early phases of SARS-CoV-2 infection with focus on ketoprofen lysine salt based on its pharmacodynamic and pharmacokinetic features.

Published
2022

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