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5 results on '"Arobelidze K"'

1. Genetic determinants supporting the multi-drug resistance of Acinetobacter spp. in Georgia

Author

Trapaidze, N., primary, Farlow, J., additional, Latif, N., additional, Nozadze, M., additional, Aptsiauri, T., additional, Mitaishvili, N., additional, Butskhrikidze, N., additional, Arobelidze, K., additional, Tavadze, V., additional, Simsive, T., additional, Kotorahsvili, A., additional, Kotaria, N., additional, Imnadze, P., additional, and Washington, M., additional

Published
2019
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2. NDM arrived to Republic of Georgia

Author

Koiava, T., primary, Gonçalves, D., additional, Palmeira, J., additional, Arobelidze, K., additional, Tediashvili, M., additional, Akhvlediani, L., additional, and Ferreira, H., additional

Published
2017
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4. DETECTION OF CTX-M GENE ANTIBIOTICS RESISTANCE IN KLEBSIELLA PNEUMONIA ISOLATES OF HOSPITALS IN ADJARA (GEORGIA)

Author

Koiava T, Gonçalves D, Palmeira J, Arobelidze K, Tediashvili M, Leila Akhvlediani, and Ferreira H

Subjects
Cross Infection, Klebsiella pneumoniae, Genes, Bacterial, Drug Resistance, Multiple, Bacterial, Humans, Georgia (Republic), Hospitals, beta-Lactam Resistance, beta-Lactamases, Anti-Bacterial Agents
Abstract

Research describing the epidemiology of antibiotic resistant microbes is vital to the proactive development of new antimicrobial agents. In the last years, CTX-M extended-spectrum β-lactamases (ESBLs) have emerged worldwide and have replaced classical TEM and SHV-type ESBLs in many countries. CTX-M-15 is currently the most frequent, with a pandemic distribution, and its rapid spread is facilitated by incorporation of resistance genes in mobile genetic elements. The ESBL is efficacious in Gram-negative bacteria and thus closely associated with nosocomial environments, often colonizing the intestines, particularly in older and dependent patients. Little is known about the CTX-M ESBLs among Klebsiella pneumonia in Adjara. Our paper describes the detected and characterized ESBLs among Klebsiella pneumonia isolates from patients in two different hospitals in Adjara.

5. Comparative genomic analysis of four multidrug-resistant isolates of Acinetobacter baumannii from Georgia.

Author

Farlow J, Nozadze M, Mitaishvili N, Kotorashvili A, Kotoria N, Arobelidze K, Tavadze V, Simsive T, Imnadze P, Latif N, Nikolich MP, Washington M, Hinkle MK, Kwon P, and Trapaidze N

Subjects
Bacterial Typing Techniques, Genomics, Georgia, Humans, Multilocus Sequence Typing, Acinetobacter Infections microbiology, Acinetobacter baumannii drug effects, Acinetobacter baumannii genetics, Drug Resistance, Multiple, Bacterial, Genome, Bacterial
Abstract

Objectives: This study reports the draft genomes of four newly isolated multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) isolates (0830, 0365, 4022, and 2846) from western Georgia to identify putative antimicrobial resistance genes (ARGs) and to determine the clonal subtypes of local clinical isolates., Methods: An Illumina MiSeq sequencer was used to perform whole-genome sequencing (WGS). The Vitek 2 automated system was used for microbial identification and antimicrobial resistance profiling., Results: Taxonomical identification as A. baumannii was confirmed by WGS. In silico analyses resolved their ARG content and clonal relatedness using the Oxford (Oxf) and Pasteur (Pas) multi-locus sequence typing schemes. Isolates 0365 and 4022 displayed similar allelic profiles corresponding to ST944Oxf/ST78Pas. Isolate 2846 displayed a different allelic profile consistent with ST19Pas/IC 1 (International or European Clone I) and exhibited a novel Oxford ST that was designated as 1868. Isolate 0830 displayed the ST78Pas allelic profile, similar to isolates 0365 and 4022, and also possessed a single allelic mismatch in the gpi gene, resulting in an ST1104Oxf allele profile in the Oxford typing scheme., Conclusion: Circulating MDR A. baumannii exhibited genetic heterogeneity with variations in the structure and content of genomic A. baumannii resistance islands and encoded multiple putative ARGs. This report represents the first clonal subtype information and genomic characterization of MDR A. baumannii in Georgia and may inform future epidemiological investigations., (Copyright © 2019 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Published
2020
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