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1. Treatment Efficacy and Clinical Effectiveness of EEG Neurofeedback as a Personalized and Multimodal Treatment in ADHD: A Critical Review

Author

Garcia Pimenta M, Brown T, Arns M, and Enriquez-Geppert S

Subjects
neurofeedback, adhd, treatment efficacy, effectiveness, personalized, multimodal, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Miguel Garcia Pimenta,1 Trevor Brown,2 Martijn Arns,3– 5 Stefanie Enriquez-Geppert1,6 1Department of Clinical and Developmental Neuropsychology, University of Groningen, Groningen, the Netherlands; 2NeuroCare Group, Melbourne, Australia; 3Department of Psychiatry, Amsterdam UMC, University of Amsterdam, Location AMC, Amsterdam Neuroscience, Amsterdam, the Netherlands; 4Research Institute Brainclinics, Brainclinics Foundation, Nijmegen, the Netherlands; 5Department of Cognitive Neuroscience, Faculty of Psychology and Neuroscience, Maastricht University, Maastricht, the Netherlands; 6Department of Biomedical Sciences of Cells & Systems, Section of Cognitive Neuropsychiatry, University of Groningen, Groningen, the NetherlandsCorrespondence: Miguel Garcia PimentaDepartment of Clinical and Developmental Neuropsychology, Faculty of Behavioural and Social Sciences, University of Groningen, Grote Kruisstraat 2/1, Groningen, 9712 TS, the NetherlandsTel +31 50 363 6537Email m.garcia.pimenta@rug.nlPurpose: Recent reviews have proposed that scientifically validated standard EEG neurofeedback (NF) protocols are an efficacious and specific treatment for attention-deficit hyperactivity disorder (ADHD). Here, we review the current evidence for the treatment efficacy and clinical effectiveness of NF in ADHD to investigate whether NF treatment personalization (standard protocols matched to the electrophysiological features of ADHD) and combination with other interventions (psychosocial, sleep hygiene and nutritional advice) might yield superior long-term treatment outcomes relative to non-personalized NF and medication monotreatments.Methods: The electronic databases PubMed and PsycINFO were systematically searched using our key terms. Of the 38 resulting studies, 11 randomized controlled trials (RCTs) and open-label studies were eligible for inclusion. Studies were analyzed for effect sizes and remission rates at the end of treatment and at follow-up. The effects of personalized and multimodal NF treatments were compared to non-personalized NF monotreatments and with two benchmark medication studies.Results: The analysis of RCTs indicated that the long-term effects of personalized NF interventions were superior to non-personalized NF and comparable to those of medication alone or in combination with behavioral intervention. The analysis of open-label trials further indicates that the interaction of NF with parental interventions, sleep and nutritional advice might yield superior clinical effectiveness relative to NF and medication monotreatments.Conclusion: Personalized and multimodal NF interventions seem to yield superior treatment efficacy relative to NF alone and superior clinical effectiveness relative to medication. We propose that treatment outcomes may be further enhanced by adjusting NF non-specific factors (eg, reinforcement contingencies) to specific ADHD characteristics (eg, reward sensitivity). Future NF research should focus on the systematic evaluation of the treatment outcomes of personalized and multimodal treatments.Keywords: neurofeedback, ADHD, treatment efficacy, effectiveness, personalized, multimodal

Published
2021

2. Altered resting state EEG in chronic pancreatitis patients: toward a marker for chronic pain

Author

de Vries M, Wilder-Smith OH, Jongsma ML, van den Broeke EN, Arns M, van Goor H, and van Rijn CM

Subjects
Medicine (General), R5-920
Abstract

Marjan de Vries,1 Oliver HG Wilder-Smith,2 Marijtje LA Jongsma,3 Emanuel N van den Broeke,1 Martijn Arns,5,6 Harry van Goor,1 Clementina M van Rijn4 1Department of Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; 2Department of Anesthesiology, Pain and Palliative Care, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands; 3Behavioral Science Institute, Radboud University Nijmegen, Nijmegen, The Netherlands; 4Donders Institute for Brain, Cognition and Behavior, Radboud University Nijmegen, Nijmegen, The Netherlands; 5Research Institute Brainclinics Nijmegen, Nijmegen, The Netherlands; 6Department of Experimental Psychology, Utrecht University, Utrecht, The Netherlands Objectives: Electroencephalography (EEG) may be a promising source of physiological biomarkers accompanying chronic pain. Several studies in patients with chronic neuropathic pain have reported alterations in central pain processing, manifested as slowed EEG rhythmicity and increased EEG power in the brain's resting state. We aimed to investigate novel potential markers of chronic pain in the resting state EEG of patients with chronic pancreatitis. Participants: Resting state EEG data from 16 patients with persistent abdominal pain due to chronic pancreatitis (CP) were compared to data from healthy controls matched for age, sex and education. Methods: The peak alpha frequency (PAF) and power amplitude in the alpha band (7.5–13 Hz) were compared between groups in four regions of interest (frontal, central, parietal, and occipital) and were correlated with pain duration. Results: The average PAF was lowered in CP patients compared with that in healthy controls, observed as a statistically significant between-group effect (mean 9.9 versus 9.5 Hz; P=0.049). Exploratory post hoc analysis of average PAF per region of interest revealed a significant difference, particularly in the parietal and occipital regions. In addition, we observed a significant correlation between pain duration and PAF and showed increased shifts in PAF with longer pain durations. No significant group differences were found in peak power amplitudes. Conclusion: CP pain is associated with alterations in spontaneous brain activity, observed as a shift toward lower PAF. This shift correlates with the duration of pain, which demonstrates that PAF has the potential to be a clinically feasible biomarker for chronic pain. These findings could be helpful for assisting diagnosis, establishing optimal treatment, and studying efficacy of new therapeutic agents in chronic pain patients. Keywords: chronic pain, neuropathic pain, chronic pancreatitis, electroencephalography, EEG, alpha oscillations, peak frequency

Published
2013

5. Brainmarker-I differentially predicts remission to various attention-deficit/hyperactivity disorder treatments: A blinded discovery, transfer and validation study

Author

Voetterl, H., Wingen, G.A. van, Michelini, G., Griffiths, K., Gordon, E., Debeus, R., Korgaonkar, M., Loo, S., Palmer, D., Breteler, M.H.M., Denys, D.A.J.P., Arnold, L.E., Du Jour, P., Ruth, R. van, Jansen, J., Dijk, H. van, Arns, M., Voetterl, H., Wingen, G.A. van, Michelini, G., Griffiths, K., Gordon, E., Debeus, R., Korgaonkar, M., Loo, S., Palmer, D., Breteler, M.H.M., Denys, D.A.J.P., Arnold, L.E., Du Jour, P., Ruth, R. van, Jansen, J., Dijk, H. van, and Arns, M.

Abstract

Contains fulltext : 247442.pdf (Publisher’s version ) (Open Access), Background: Attention-deficit/hyperactivity disorder is characterized by neurobiological heterogeneity, possibly explaining why not all patients benefit from a given treatment. As a means to select the right treatment (stratification), biomarkers may aid in personalizing treatment prescription, thereby increasing remission rates. Methods: The biomarker in this study was developed in a heterogeneous clinical sample (N=4249), and first applied to two large transfer datasets, a priori stratifying young males (<18 years) with a higher individual alpha peak frequency (iAPF) to methylphenidate (N=336) and those with a lower iAPF to multimodal Neurofeedback, complemented with sleep coaching (N=136). Blinded, out-of-sample validations were conducted in two independent samples. In addition, the association between iAPF and response to Guanfacine and Atomoxetine was explored. Results: Retrospective stratification in the transfer datasets resulted in a predicted gain in normalized remission of 17-30%. Blinded out-of-sample validations for methylphenidate (N=41) and multimodal Neurofeedback (N=71) corroborated these findings, yielding a predicted gain in stratified normalized remission of 36% and 29%, respectively. Conclusion: The present study introduces a clinically interpretable and actionable biomarker based on the iAPF assessed during resting-state electroencephalography. Our findings suggest that acknowledging neurobiological heterogeneity can inform stratification of patients to their individual best treatment and enhance remission rates.

Published
2023

8. Brainmarker-I differentially predicts remission to various attention-deficit/hyperactivity disorder treatments: A blinded discovery, transfer and validation study

Author

Voetterl, H., Wingen, G.A. van, Michelini, G., Griffiths, K., Gordon, E., Debeus, R., Korgaonkar, M., Loo, S., Palmer, D., Breteler, M.H.M., Denys, D.A.J.P., Arnold, L.E., Du Jour, P., Ruth, R. van, Jansen, J., Dijk, H. van, Arns, M., Voetterl, H., Wingen, G.A. van, Michelini, G., Griffiths, K., Gordon, E., Debeus, R., Korgaonkar, M., Loo, S., Palmer, D., Breteler, M.H.M., Denys, D.A.J.P., Arnold, L.E., Du Jour, P., Ruth, R. van, Jansen, J., Dijk, H. van, and Arns, M.

Abstract

28 februari 2022, Item does not contain fulltext, Background: Attention-deficit/hyperactivity disorder is characterized by neurobiological heterogeneity, possibly explaining why not all patients benefit from a given treatment. As a means to select the right treatment (stratification), biomarkers may aid in personalizing treatment prescription, thereby increasing remission rates. Methods: The biomarker in this study was developed in a heterogeneous clinical sample (N=4249), and first applied to two large transfer datasets, a priori stratifying young males (<18 years) with a higher individual alpha peak frequency (iAPF) to methylphenidate (N=336) and those with a lower iAPF to multimodal Neurofeedback, complemented with sleep coaching (N=136). Blinded, out-of-sample validations were conducted in two independent samples. In addition, the association between iAPF and response to Guanfacine and Atomoxetine was explored. Results: Retrospective stratification in the transfer datasets resulted in a predicted gain in normalized remission of 17-30%. Blinded out-of-sample validations for methylphenidate (N=41) and multimodal Neurofeedback (N=71) corroborated these findings, yielding a predicted gain in stratified normalized remission of 36% and 29%, respectively. Conclusion: The present study introduces a clinically interpretable and actionable biomarker based on the iAPF assessed during resting-state electroencephalography. Our findings suggest that acknowledging neurobiological heterogeneity can inform stratification of patients to their individual best treatment and enhance remission rates.

Published
2022

9. rTMS combined with CBT as a next step in antidepressant non-responders: A study protocol for a randomized comparison with current antidepressant treatment approaches

Author

Dalhuisen, A.I., Smit, F., Spijker, J., Oostrom, I.I. van, Exel, E. van, Mierlo, H.C. van, Waardt, D. de, Arns, M., Tendolkar, I., Eijndhoven, P.F. van, Dalhuisen, A.I., Smit, F., Spijker, J., Oostrom, I.I. van, Exel, E. van, Mierlo, H.C. van, Waardt, D. de, Arns, M., Tendolkar, I., and Eijndhoven, P.F. van

Abstract

Contains fulltext : 246545.pdf (Publisher’s version ) (Open Access), Major depressive disorder (MDD) is one of the most common psychiatric disorders, however, current treatment options are insufficiently effective for about 35% of patients, resulting in treatment-resistant depression (TRD). Repetitive transcranial magnetic stimulation (rTMS) is a form of non-invasive neuromodulation that is effective in treating TRD. Not much is known about the comparative efficacy of rTMS and other treatments and their timing within the treatment algorithm, making it difficult for the treating physician to establish when rTMS is best offered as a treatment option. This study aims to investigate the (cost-)effectiveness of rTMS (in combination with cognitive behavioral therapy (CBT) and continued antidepressant medication), compared to the next step in the treatment algorithm. This will be done in a sample of patients with treatment resistant non-psychotic unipolar depression.

Published
2022

10. Interrogating Associations Between Polygenic Liabilities and Electroconvulsive Therapy Effectiveness.

Author

Luykx, JJ, Loef, D, Lin, B, van Diermen, L, Nuninga, JO, van Exel, E, Oudega, ML, Rhebergen, D, Schouws, SNTM, van Eijndhoven, P, Verwijk, E, Schrijvers, D, Birkenhager, TK, Ryan, KM, Arts, B, van Bronswijk, SC, Kenis, G, Schurgers, G, Baune, BT, Arns, M, van Dellen, EE, Somers, M, Sommer, IEC, Boks, MP, Gülöksüz, S, McLoughlin, DM, Dols, A, Rutten, BPF, Luykx, JJ, Loef, D, Lin, B, van Diermen, L, Nuninga, JO, van Exel, E, Oudega, ML, Rhebergen, D, Schouws, SNTM, van Eijndhoven, P, Verwijk, E, Schrijvers, D, Birkenhager, TK, Ryan, KM, Arts, B, van Bronswijk, SC, Kenis, G, Schurgers, G, Baune, BT, Arns, M, van Dellen, EE, Somers, M, Sommer, IEC, Boks, MP, Gülöksüz, S, McLoughlin, DM, Dols, A, and Rutten, BPF

Abstract

BACKGROUND: Electroconvulsive therapy (ECT) is the most effective treatment for severe major depressive episodes (MDEs). Nonetheless, firmly established associations between ECT outcomes and biological variables are currently lacking. Polygenic risk scores (PRSs) carry clinical potential, but associations with treatment response in psychiatry are seldom reported. Here, we examined whether PRSs for major depressive disorder, schizophrenia (SCZ), cross-disorder, and pharmacological antidepressant response are associated with ECT effectiveness. METHODS: A total of 288 patients with MDE from 3 countries were included. The main outcome was a change in the 17-item Hamilton Depression Rating Scale scores from before to after ECT treatment. Secondary outcomes were response and remission. Regression analyses with PRSs as independent variables and several covariates were performed. Explained variance (R2) at the optimal p-value threshold is reported. RESULTS: In the 266 subjects passing quality control, the PRS-SCZ was positively associated with a larger Hamilton Depression Rating Scale decrease in linear regression (optimal p-value threshold = .05, R2 = 6.94%, p < .0001), which was consistent across countries: Ireland (R2 = 8.18%, p = .0013), Belgium (R2 = 6.83%, p = .016), and the Netherlands (R2 = 7.92%, p = .0077). The PRS-SCZ was also positively associated with remission (R2 = 4.63%, p = .0018). Sensitivity and subgroup analyses, including in MDE without psychotic features (R2 = 4.42%, p = .0024) and unipolar MDE only (R2 = 9.08%, p < .0001), confirmed the results. The other PRSs were not associated with a change in the Hamilton Depression Rating Scale score at the predefined Bonferroni-corrected significance threshold. CONCLUSIONS: A linear association between PRS-SCZ and ECT outcome was uncovered. Although it is too early to adopt PRSs in ECT clinical decision making, these findings strengthen the positioning of PRS-SCZ as relevant to treatment response in psychiatry.

Published
2022

13. Individual alpha frequency proximity associated with repetitive transcranial magnetic stimulation outcome: An independent replication study from the ICON-DB consortium

Author

Roelofs, C.L., Krepel, N., Corlier, J., Carpenter, L.L., Fitzgerald, P.B., Daskalakis, Z.J., Tendolkar, I., Wilson, A., Downar, J., Bailey, N.W., Blumberger, D.M., Leuchter, A.F., Arns, M., Vila-Rodriguez, F., Roelofs, C.L., Krepel, N., Corlier, J., Carpenter, L.L., Fitzgerald, P.B., Daskalakis, Z.J., Tendolkar, I., Wilson, A., Downar, J., Bailey, N.W., Blumberger, D.M., Leuchter, A.F., Arns, M., and Vila-Rodriguez, F.

Abstract

Contains fulltext : 231309.pdf (Publisher’s version ) (Open Access), Objective: The aim of the current study was to attempt to replicate the finding that the individual alpha frequency (IAF) as well as the absolute difference between IAF and 10 Hz stimulation frequency (IAF-prox) is related to treatment outcome. Methods: Correlations were performed to investigate the relationship between IAF-prox and percentage symptom improvement in a sample of 153 patients with major depressive disorder treated with 10 Hz (N = 59) to the left dorsolateral prefrontal cortex (DLPFC) or 1 Hz (N = 94) to the right DLPFC repetitive Transcranial Magnetic Stimulation (rTMS). Results: There was a significant negative correlation between IAF-prox and the percentage of symptom improvement only for the 10 Hz group. Curve fitting models revealed that there was a quadratic association between IAF and treatment response in the 10 Hz group, with a peak at 10 Hz IAF. Conclusion: The main result of Corlier and colleagues was replicated, and the findings suggest that the distance between 10 Hz stimulation frequency and the IAF may influence clinical outcome in a non-linear manner. Significance: rTMS is often administered at a frequency of 10 Hz, which is the center of the EEG alpha frequency band. The results can make a significant contribution to optimizing the clinical application of rTMS.

Published
2021

14. On the numerical analysis of inhomogeneous continuous-time Markov chains

Author

Arns, M., Buchholz, P., and Panchenko, A.

Subjects
Numerical analysis -- Methods -- Analysis, Markov processes -- Analysis -- Methods
Abstract

Inhomogeneous continuous-time Markov chains play an important role in different application areas. In contrast to homogeneous continuous-time Markov chains, where a large number of numerical analysis techniques are available and [...]

Published
2010
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19. 3 e Conférence européenne sur la stimulation cérébrale en psychiatrie – Des mécanismes à l'application thérapeutique

Author

Brunelin, J, Mondino, M, Arns, M, Baeken, C, Brem, A-K, Filipčić, I, Ganho-Avila, A, Palm, U, Poleszczyk, A, Sauvaget, A, O'Shea, J, D'Urso, G, Poulet, E, Brein, Lichaam en Cognitie, Observerende Klinische wetenschappen, Neuroprotectie & Neuromodulatie, and Psychiatrie

Subjects
Psychiatry and Mental health, Arts and Humanities (miscellaneous)
Published
2019
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20. Consensus statement on the application of rtms in depression in the Netherlands and Belgium

Author

Arns, M., Bervoets, C., van Eijndhoven, P., Baeken, C., van den Heuvel, O. A., Aleman, A., Schutter, D. J. L. G., van der Werf, Y., van Belkum, S., Sommer, I. E., van Ruth, R., Haarman, B., Spijker, J., Sack, A. T., Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Psychiatry, and Anatomy and neurosciences

Subjects
Depressive Disorder, Major, Depressive Disorder, Treatment-Resistant, Consensus, Treatment Outcome, Belgium, nervous system, musculoskeletal, neural, and ocular physiology, mental disorders, Humans, Transcranial Magnetic Stimulation, behavioral disciplines and activities, psychological phenomena and processes, Netherlands
Abstract

Since 2017, repetitive transcranial magnetic stimulation (rTMS) has become eligible for reimbursement for the treatment of therapy-resistant depression in the Dutch healthcare system. AIM: To initiate a guideline in the Netherlands and Belgium for the safe and effective application of rTMS for the treatment of depression. METHOD: Based on literature review, existing guidelines and consensus among Dutch rTMS experts, recommendations were developed regarding the implementation of rTMS as a treatment of depression. All available evidence was weighed and discussed among all co-authors and recommendations were reached by consensus among the group. RESULTS: rTMS targeting the dorsolateral prefrontal cortex (DLPFC) should be seen as a first choice in the treatment of depression using high-frequency rTMS (left) or, as an alternative, low-frequency rTMS (right). Stimulation protocols should use more than 1000 pulses per session for an average of 20-30 sessions, offered in 2-5 sessions per week. Contraindications for rTMS include epilepsy, intracranial presence of (magnetisable) metals, pacemaker and cochlear implant. CONCLUSION: rTMS, performed by competent professionals is an effective and safe treatment for depression. ispartof: Tijdschr Psychiatr vol:61 issue:6 pages:411-420 ispartof: location:Netherlands status: published

Published
2019

23. The Role of Gene Encoding Variation ofDRD4in the Relationship between Inattention and Seasonal Daylight

Author

Vollebregt, M.A., primary, Franke, B., additional, Buitelaar, J.K., additional, Arnold, L.E., additional, Faraone, S.V., additional, Grevet, E.H., additional, Reif, A., additional, Zayats, T., additional, Bralten, J., additional, Bau, C.H.D., additional, Haavik, J., additional, Kuntsi, J., additional, Cupertino, R.B., additional, Loo, S.K., additional, Lundervold, A.J., additional, Ribasés, M., additional, Sánchez-Mora, C., additional, Ramos-Quiroga, J.A., additional, Asherson, P., additional, Swanson, J.M., additional, and Arns, M., additional

Published
2019
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27. Differences in Cortical Sources of the Event-Related P3 Potential Between Young and Old Participants Indicate Frontal Compensation

Author

van Dinteren, R., Huster, R. J., Jongsma, M. L.A., Kessels, R. P.C., Arns, M., van Dinteren, R., Huster, R. J., Jongsma, M. L.A., Kessels, R. P.C., and Arns, M.

Abstract

The event-related P3 potential, as elicited in auditory signal detection tasks, originates from neural activity of multiple cortical structures and presumably reflects an overlap of several cognitive processes. The fact that the P3 is affected by aging makes it a potential metric for age-related cognitive change. The P3 in older participants is thought to encompass frontal compensatory activity in addition to task-related processes. The current study investigates this by decomposing the P3 using group independent component analysis (ICA). Independent components (IC) of young and old participants were compared in order to investigate the effects of aging. Exact low-resolution tomography analysis (eLORETA) was used to compare current source densities between young and old participants for the P3-ICs to localize differences in cortical source activity for every IC. One of the P3-related ICs reflected a different constellation of cortical generators in older participants compared to younger participants, suggesting that this P3-IC reflects shifts in neural activations and compensatory processes with aging. This P3-IC was localized to the orbitofrontal/temporal, and the medio-parietal regions. For this IC, older participants showed more frontal activation and less parietal activation as measured on the scalp. The differences in cortical sources were localized in the precentral gyrus and the parahippocampal gyrus. This finding might reflect compensatory activity recruited from these cortical sources during a signal detection task.

Published
2018

29. Differences in Cortical Sources of the Event-Related P3 Potential Between Young and Old Participants Indicate Frontal Compensation

Author

Afd Psychologische functieleer, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), van Dinteren, R., Huster, R. J., Jongsma, M. L.A., Kessels, R. P.C., Arns, M., Afd Psychologische functieleer, Helmholtz Institute, Experimental Psychology (onderzoeksprogramma PF), van Dinteren, R., Huster, R. J., Jongsma, M. L.A., Kessels, R. P.C., and Arns, M.

Published
2018

30. EEG Neurofeedback for executive functions in children with neurodevelopmental challenges:Review protocol

Author

Landes, J, Reid, Corinne, Arns, M, Badcock, N, Ros, T, Bulsara, M, Brini, S, Rabipour, S, Enriquez-Geppert, S, Mason, M, Birbaumer, N, Gouldthorp, B, and Anderson, Michael

Subjects
education
Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:To assess the effectiveness of EEG neurofeedback as treatment for inhibition and updating problems in children facing neurodevelopmental challenges.

Published
2017
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31. Niet-invasieve hersenstimulatie bij psychiatrische stoornissen: beïnvloedende factoren en combinatie van intervenues

Author

Vanderhasselt, M. A., Dedoncker, J., Arns, M., Baeken, C., Afd Psychologische functieleer, Helmholtz Institute, and Experimental Psychology (onderzoeksprogramma PF)

Subjects
TDcs, Psychiatry and Mental health, Psychiatric disorder, ITMS
Abstract

BACKGROUND Thecausal influence of cortico-subcortical connectivity by means of brain stimulation seems to bean effective biological treatment in psychiatric patients. AIM To review the working mechanisms and moderating factors of two non-invasive brain stimulation techniques (NIBS), namely repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (toes). METHOD We reviewed the current literature on the use of NIBS in neuropsychiatrie disorders. RESULTS First of all, stimulation parameters (location of the stimulation, intensity and duration of the stimulation, number of sessions) are important for the effect of NIBS. Secondly, it is important to consider the non-specific neuroplasticity that results from NIBS.Thirdly, recent studies suggest that NIBS should be combined with neurobehavioral interventions, namely cognitive interventions, for the purpose of modulating specific neural processes (i.e. specific neuroplasticity). CONCLUSION If we want to Improve the NIBS treatment in neuropsychiatrie patients, we need to consider the factors that influence the patients' response to treatment with ITMS and tDCS.

Published
2017

33. EEG neurofeedback for executive functions in children with neurodevelopmental challenges

Author

Landes, J.K., Reid, C.L., Arns, M., Badcock, N.A., Ros, T., Enriquez-Geppert, S., Bulsara, M.K., Brini, S., Rabipour, S., Mason, M., Birbaumer, N., Gouldthorp, B., Anderson, M., Landes, J.K., Reid, C.L., Arns, M., Badcock, N.A., Ros, T., Enriquez-Geppert, S., Bulsara, M.K., Brini, S., Rabipour, S., Mason, M., Birbaumer, N., Gouldthorp, B., and Anderson, M.

Abstract

This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: To assess the effectiveness of EEG neurofeedback as treatment for inhibition and updating problems in children facing neurodevelopmental challenges.

Published
2017

37. Neurofeedback: One of today's techniques in psychiatry?

Author

Arns, M., primary, Batail, J.-M., additional, Bioulac, S., additional, Congedo, M., additional, Daudet, C., additional, Drapier, D., additional, Fovet, T., additional, Jardri, R., additional, Le-Van-Quyen, M., additional, Lotte, F., additional, Mehler, D., additional, Micoulaud-Franchi, J.-A., additional, Purper-Ouakil, D., additional, and Vialatte, F., additional

Published
2017
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40. The do's and don'ts for electrophysiological connectivity analysis

Author

Luijtelaar, G. van, Olbrich, S., Jobert, M., Prichep, L., Vollebregt, M., Arns, M., Schoffelen, J.M., Luijtelaar, G. van, Olbrich, S., Jobert, M., Prichep, L., Vollebregt, M., Arns, M., and Schoffelen, J.M.

Abstract

19th Biennial Meeting of the Pharmaco-EEG Society (IPEG 2016), Nijmegen, the Netherlands, 26-30 oktober 2016, Item does not contain fulltext, In recent years it has been increasingly recognized that insight into the dynamics of interareal interactions is crucial for our understanding of normal and pathological brain function. Methodological developments and open source availability of advanced analysis tools have enabled the wider neuroscientific community to estimate a wide range of connectivity metrics from non-invasively obtained electrophysiological signals. Next to deciding on an appropriate analysis strategy, researchers are faced with the challenge to correctly interpret their findings. Volume conduction and electromagnetic field spread cause neuronal signals to be picked up by multiple channels at once, causing spurious estimates of connectivity. Comparison across experimental groups and conditions may be confounded by differences in univariate signal properties such as signal-to-noise ratio. I will illustrate some of these interpretational pitfalls and provide some recommendations that may need to be taken into account to improve the validity of the interpretation of EEG/ MEG connectivity studies.

Published
2016

41. De rol van slaap bij ADHD: Mogelijkheden voor preventie van ADHD?

Author

Arns, M., Experimental Psychology (onderzoeksprogramma PF), Afd Psychologische functieleer, and Helmholtz Institute

Subjects
Psychiatry and Mental health, ADHD, Biomarker, EEG, Neurofeedback, Chronobiology
Abstract

Background: Personalized medicine aims to provide the right treatment for the right person at the right time, as opposed to the currently employed 'one-size-fits-all' approach. This developmentrelies on identification of ADHD subgroups using biomarkers. One important ADHD subgroup is characterised by impaired vigilance regulation, as quantified by the eeg and this subgroup responds well to stimulant medication and neurofeedback. Recent insights suggest a clear association between reduced sleep duration and adhd complaints in this sub-group of adhd patients. A recently published model explains how different treatments e.g. chronobiological treatments and neurofeedback impact on this neural circuitry and mediate adhd symptom improvement. Aim: To test this recently published model predicting a relationship between solar intensity and adhd prevalence. Method: A literature survey onstudies using identical methods to estimate the prevalence of adhd in differentgeographical areas and compare those to worldwide solar intensity data. Results: A clear relationship between solar intensity and the worldwide prevalence of ADH D was found, explaining 34-57% of the variance in adhd prevalence, where a lower prevalence of adhd was found in areas with high solar-intensity. Conclusion: The preventative eject of high solar intensity may be related to improvement of circadian clock disturbances. These findings likely apply to a substantial sub-group of A DHD patients and have major implications for our understanding of the etiology and possibly prevention Of adhd.

Published
2013

42. Neoadjuvante Chemo- oder Chemoradiotherapie gefolgt von Resektion bei lokal fortgeschrittenem Nicht-Kleinzelligem Lungekarzinom – eine retrospektive institutionelle Studie

Author

Hoda, A, primary, Klikovits, T, additional, Steindl, A, additional, Nguyen, MQ, additional, Waseda, R, additional, Arns, M, additional, Schenk, P, additional, Lang, G, additional, Taghavi, S, additional, Dieckmann, K, additional, Zöchbauer-Müller, S, additional, Pirker, R, additional, Klepetko, W, additional, and Aigner, C, additional

Published
2015
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45. Habituation effects on Somatosensory Event-related Potentials (SEPs) elicited by painful electrical stimuli

Author

van Rijn, C.M., Jongsma, M.L.A., van den Broeke, E., Postma, S., van der Lubbe, R., Buitenweg, J.R., Arns, M., Quian Quiroga, R., van Goor, H., Luckers, M., and Wilder-Smith, O.H.G.

Subjects
METIS-235011
Abstract

Background and Aims: Pain perception is typically measured by questionnaires and behavioural responses. Somatosensory Evoked Potentials (SEPs), however, provide a direct measure of stimulus processing in the brain. We studied how stimulus repetition influences the SEPs. Methods: A multi-channel EEG was recorded (band pass 0.1−100Hz, sample frequency 1000Hz) from 11 volunteers. Electrical stimuli were applied to the middle phalange of the left ring finger. Each trial consisted of 30 stimuli (1 s duration); inter-stimulus interval of 4 seconds. Three trials were recorded, corresponding with subjective intensity levels 5 (pain detection), 7 (moderate pain) and 9 (pain tolerance). Electric stimuli thus ranged from 1 to 25 mA. Mean amplitudes were extracted from single EEG epochs at Cz: N1: 115–125 ms, P2: 185–195 ms, N2: 195–205 ms and P3: 250–270 ms. Results and Discussion: The N1 component of the SEP decreased between the first and second stimulus. The P3 wave decreased slower; over 4 to 5 stimuli. For the amplitude of the N1 no differences were observed between the three VAS scores. For those of the P3, the amplitudes of the VAS 5 were lower than those of the two higher VAS scores. The amplitude of the N1 reaching an asymptotic level after the second stimulus in the trains, is consistent with those of many earlier studies [ref: J. Kekoni]. The slow habituation of the P3 component contrasts the sensitization in subjective VAS scores found in a parallel experiment. It will be interesting to study whether this SEP habituation differs between chronic pain patients and healthy volunteers.

Published
2006

46. EEG Markers for Cognitive Decline in Elderly Subjects with subjective memory complaints

Author

Alexander, D, Arns, M, Paul, R, Rowe, D, Cooper, N, Esser, A, and Fallahpour, K

Subjects
Central Nervous System, subjective memory, complaint, cognition, EEG
Abstract

New treatments for Alzheimer's disease require early detection of cognitive decline. Most studies seeking to identify markers of early cognitive decline have focused on a limited number of measures. We sought to establish the profile of brain function measures which best define early neuropsychological decline. We compared subjects with subjective memory complaints to normative controls on a wide range of EEG derived measures, including a new measure of event-related spatio-temporal waves and biophysical modeling, which derives anatomical and physiological parameters based on subject's EEG measurements. Measures that distinguished the groups were then related to cognitive performance on a variety of learning and executive function tasks. The EEG measures include standard power measures, peak alpha frequency, EEG desynchronization to eyes-opening, and global phase synchrony. The most prominent differences in subjective memory complaint subjects were elevated alpha power and an increased number of spatio-temporal wave events. Higher alpha power and changes in wave activity related most strongly to a decline in verbal memory performance in subjects with subjective memory complaints, and also declines in maze performance and working memory reaction time. Interestingly, higher alpha power and wave activity were correlated with improved performance in reverse digit span in the subjective memory complaint group. The modeling results suggest that differences in the subjective memory complaint subjects were due to a decrease in cortical and thalamic inhibitory gains and slowed dendritic time-constants. The complementary profile that emerges from the variety of measures and analyses points to a nonlinear progression in electrophysiological changes from early neuropsychological decline to late-stage dementia, and electrophysiological changes in subjective memory complaint that vary in their relationships to a range of memory-related tasks.

Published
2006

48. Circulating fibrinogen is a prognostic and predictive biomarker in malignant pleural mesothelioma

Author

Ghanim, B, primary, Hoda, M A, additional, Klikovits, T, additional, Winter, M-P, additional, Alimohammadi, A, additional, Grusch, M, additional, Dome, B, additional, Arns, M, additional, Schenk, P, additional, Jakopovic, M, additional, Samarzija, M, additional, Brcic, L, additional, Filipits, M, additional, Laszlo, V, additional, Klepetko, W, additional, Berger, W, additional, and Hegedus, B, additional

Published
2014
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