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2. OCT retinal nerve fiber layer thickness differentiates acute optic neuritis from MOG antibody-associated disease and Multiple Sclerosis RNFL thickening in acute optic neuritis from MOGAD vs MS

Author

Chen, John J, Sotirchos, Elias S, Henderson, Amanda D, Vasileiou, Eleni S, Flanagan, Eoin P, Bhatti, M Tariq, Jamali, Sepideh, Eggenberger, Eric R, Dinome, Marie, Frohman, Larry P, Arnold, Anthony C, Bonelli, Laura, Seleme, Nicolas, Mejia-Vergara, Alvaro J, Moss, Heather E, Padungkiatsagul, Tanyatuth, Stiebel-Kalish, Hadas, Lotan, Itay, Hellmann, Mark A, Hodge, Dave, Oertel, Frederike Cosima, Paul, Friedemann, Saidha, Shiv, Calabresi, Peter A, and Pittock, Sean J

Subjects
Clinical Research, Brain Disorders, Autoimmune Disease, Eye Disease and Disorders of Vision, Multiple Sclerosis, Neurosciences, Neurodegenerative, Neurological, Adult, Cross-Sectional Studies, Female, Humans, Middle Aged, Nerve Fibers, Optic Neuritis, Tomography, Optical Coherence, Myelin oligodendrocyte glycoprotein, MOG antibody-associated disease, Optic neuritis, Optical coherence tomography, Peripapillary retinal nerve fiber layer
Abstract

BackgroundOptic neuritis (ON) is the most common manifestation of myelin oligodendrocyte glycoprotein antibody associated disorder (MOGAD) and multiple sclerosis (MS). Acute ON in MOGAD is thought to be associated with more severe optic disk edema than in other demyelinating diseases, but this has not been quantitatively confirmed. The goal of this study was to determine whether optical coherence tomography (OCT) can distinguish acute ON in MOGAD from MS, and establish the sensitivity of OCT as a confirmatory biomarker of ON in these entities.MethodsThis was a multicenter cross-sectional study of MOGAD and MS patients with peripapillary retinal nerve fiber layer (pRNFL) thickness measured with OCT within two weeks of acute ON symptom. Cirrus HD-OCT (Carl Zeiss Meditec, Inc. Dublin, CA, USA) was used to measure the pRNFL during acute ON. Eyes with prior ON or disk pallor were excluded. A receiver operating characteristic (ROC) curve analysis was performed to assess the ability of pRNFL thickness to distinguish MOGAD from MS.ResultsSixty-four MOGAD and 50 MS patients met study inclusion criteria. Median age was 46.5 years (interquartile range [IQR]: 34.3-57.0) for the MOGAD group and 30.4 years (IQR: 25.7-38.4) for the MS group (p

Published
2022

3. Trans-synaptic degeneration of the optic radiation from optic nerve atrophy

Author

Kihira, Shingo, Arnold, Anthony C, Pawha, Puneet S, Villablanca, Pablo, and Nael, Kambiz

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Biomedical Imaging, Aging, Brain Disorders, Neurosciences, Neurodegenerative, Eye Disease and Disorders of Vision, Rare Diseases, Eye, Neurological, Optic nerve atrophy, Optic radiation, Trans-synaptic degeneration
Abstract

Fourty-seven-year-old woman with 5-year history of progressive decreased left eye vision. Optical coherence tomography showed optic nerve atrophy (left > right) and brain MRI revealed T2 hyperintense signal along the course of left optic radiations. We present a case of a trans-synaptic degeneration of the optic radiation in a patient with confirmed optic atrophy. Trans-synaptic degeneration of the optic radiation without associated infarct or inflammatory disease has not been reported before in patients with optic atrophy.

Published
2021

4. Visual Outcomes Following Plasma Exchange for Optic Neuritis: An International Multicenter Retrospective Analysis of 395 Optic Neuritis Attacks

Author

Chen, John J., Flanagan, Eoin P., Pittock, Sean J., Stern, Nicole Caroline, Tisavipat, Nanthaya, Bhatti, M. Tariq, Chodnicki, Kevin D., Tajfirouz, Deena A., Jamali, Sepideh, Kunchok, Amy, Eggenberger, Eric R., Nome, Marie A. Di, Sotirchos, Elias S., Vasileiou, Eleni S., Henderson, Amanda D., Arnold, Anthony C., Bonelli, Laura, Moss, Heather E., Navarro, Sylvia Elizabeth Villarreal, Padungkiatsagul, Tanyatuth, Stiebel-Kalish, Hadas, Lotan, Itay, Wilf-Yarkoni, Adi, Danesh-Meyer, Helen, Ivanov, Stefan, Huda, Saif, Forcadela, Mirasol, Hodge, David, Poullin, Pascale, Rode, Julie, Papeix, Caroline, Saheb, Samir, Boudot de la Motte, Marine, Vignal, Catherine, Hacohen, Yael, Pique, Julie, Maillart, Elisabeth, Deschamps, Romain, Audoin, Bertrand, and Marignier, Romain

Published
2023
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5. Details and outcomes of a large cohort of MOG-IgG associated optic neuritis

Author

Chen, John J., Flanagan, Eoin P., Bhatti, M. Tariq, Tisavipat, Nanthaya, Jamali, Sepideh, Kunchok, Amy, Eggenberger, Eric R., Nome, Marie Di, Sotirchos, Elias S., Vasileiou, Eleni S., Henderson, Amanda D., Arnold, Anthony C., Bonelli, Laura, Seleme, Nicolas, Mejia-Vergara, Alvaro J., Moss, Heather E., Padungkiatsagul, Tanyatuth, Stiebel-Kalish, Hadas, Lotan, Itay, Wilf-Yarkoni, Adi, Hellmann, Mark A., Vuppala, Amrita, Hodge, David, and Pittock, Sean J.

Published
2022
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6. Foveal and Peripapillary Vascular Decrement in Migraine With Aura Demonstrated by Optical Coherence Tomography Angiography

Author

Chang, Melinda Y, Phasukkijwatana, Nopasak, Garrity, Sean, Pineles, Stacy L, Rahimi, Mansour, Sarraf, David, Johnston, Mollie, Charles, Andrew, and Arnold, Anthony C

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Biomedical Imaging, Headaches, Clinical Research, Eye Disease and Disorders of Vision, Neurosciences, Pain Research, Migraines, Adolescent, Adult, Computed Tomography Angiography, Female, Fovea Centralis, Healthy Volunteers, Humans, Male, Middle Aged, Migraine with Aura, Migraine without Aura, Optic Disk, Tomography, Optical Coherence, Young Adult, migraine, OCT angiography, neuro-ophthalmology, Biological Sciences, Medical and Health Sciences, Ophthalmology & Optometry, Ophthalmology and optometry
Abstract

PurposeMigraine, particularly with aura, has been associated with ocular and systemic ischemic complications, but there are limited data on the ocular vasculature in migraine. We used optical coherence tomography angiography (OCTA) to assess perfusion of the macula and optic nerve in migraine patients, with (MA) and without (MO) aura, compared to healthy controls (HC).MethodsWe recruited 15 MA (mean age 42 years), 12 MO (mean age 46 years), and 22 HC (mean age 39 years) participants from neurology and neuro-ophthalmology clinics. Participants underwent optical coherence tomography and 3 × 3 mm OCTA of the macula and optic nerve. Foveal avascular zone area was automatically measured using AngioVue software, and vessel density was calculated as blood vessel length divided by scan area (mm-1) after skeletonization of OCTA images.ResultsOn macular OCTA, MA participants had an enlarged foveal avascular zone area when compared with HC (0.300 ± 0.019 vs. 0.220 ± 0.066 mm2, P = 0.006). In addition, superficial foveal vessel density was decreased in MA participants when compared with MO participants (7.8 ± 0.31 vs. 9.3 ± 0.44, P = 0.04) and HC (7.8 ± 0.31 vs. 9.4 ± 0.21 mm-1, P = 0.002). On optic nerve OCTA, the MA participants had reduced superior peripapillary vessel density when compared with the MO participants (12.0 ± 0.45 vs. 14.0 ± 0.38 mm-1, P = 0.031) and HC (12.0 ± 0.45 vs. 14.1 ± 0.53 mm-1, P = 0.035). There were no significant differences between the MO and HC groups.ConclusionsMigraine with, but not without, aura was associated with foveal and peripapillary vascular decrements, which may possibly mediate increased risk of ocular and systemic vascular complications in these patients. OCTA could potentially be useful as a biomarker for migraine with aura.

Published
2017

7. Severe bilateral optic nerve and retinal hypoperfusion in a patient with acute respiratory distress syndrome and septic shock

Author

Gui, Wei, Friesen, Erika Tanaka, Bonelli, Laura, Wang, Ye Elaine, and Arnold, Anthony C

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Hematology, Neurosciences, Neurodegenerative, Eye Disease and Disorders of Vision, Peripheral Neuropathy, Cardiovascular, Eye, Acute respiratory distress syndrome, Central retinal artery occlusion, Diffusion-weighted magnetic resonance imaging, Ischemic optic neuropathy, Septic shock
Abstract

PurposeTo report a case of bilateral central retinal artery occlusion with both anterior and posterior ischemic optic neuropathy.ObservationsA 65-year-old Caucasian woman presented with acute respiratory distress syndrome and septic shock. After treatment with vasopressors and prolonged prone positioning, she was noted to be bilaterally completely blind on hospitalization day 12. Evaluation revealed evidence of bilateral central retinal artery occlusion and bilateral ischemic optic neuropathy. Magnetic resonance imaging of the orbits demonstrated severe restricted diffusion of both optic nerves consistent with ischemia. Both central retinal artery occlusion and ischemic optic neuropathy have been reported in cases of severe hypotension, blood loss, and prone positioning, most often postoperatively after spinal surgery.Conclusions and importanceTo our knowledge, this is the first reported case of bilateral central retinal artery occlusion with both anterior and posterior ischemic optic neuropathy, presumed due to the combination of severe systemic hypotension, hypoxemia due to the respiratory distress syndrome, and prolonged prone positioning.

Published
2017

8. Progression of asymptomatic optic disc swelling to non-arteritic anterior ischaemic optic neuropathy

Author

Subramanian, Prem S, Gordon, Lynn K, Bonelli, Laura, and Arnold, Anthony C

Subjects
Biomedical and Clinical Sciences, Ophthalmology and Optometry, Neurosciences, Rare Diseases, Clinical Research, Peripheral Neuropathy, Neurodegenerative, Eye Disease and Disorders of Vision, Eye, Aged, Disease Progression, Female, Fluorescein Angiography, Humans, Male, Middle Aged, Optic Neuropathy, Ischemic, Papilledema, Tomography, Optical Coherence, Visual Acuity, Visual Field Tests, Visual Fields, Field of vision, Optic Nerve, Clinical Sciences, Opthalmology and Optometry, Public Health and Health Services, Ophthalmology & Optometry, Clinical sciences, Ophthalmology and optometry
Abstract

BackgroundThe time of onset of optic disc swelling in non-arteritic anterior ischaemic optic neuropathy (NAION) is not known, and it is commonly assumed to arise simultaneously with vision loss. Our goal is to report the presence and persistence of optic disc swelling without initial vision loss and its subsequent evolution to typical, symptomatic NAION.MethodsClinical case series of patients with optic disc swelling and normal visual acuity and visual fields at initial presentation who progressed to have vision loss typical of NAION. All subjects underwent automated perimetry, disc photography and optic coherence tomography and/or fluorescein angiography to evaluate optic nerve function and perfusion.ResultsFour patients were found to have sectoral or diffuse optic disc swelling without visual acuity or visual field loss; the fellow eye of all four had either current or prior NAION or a 'disc at risk' configuration. Over several weeks of clinical surveillance, each patient experienced sudden onset of visual field and/or visual acuity loss typical for NAION.ConclusionsCurrent treatment options for NAION once vision loss occurs are limited and may not alter the natural history of the disorder. Subjects with NAION may have disc swelling for 2-10 weeks prior to the occurrence of visual loss, and with the development of new therapeutic agents, treatment at the time of observed disc swelling could prevent vision loss from NAION.

Published
2017

9. Safety of long-term use of linezolid: results of an open-label study.

Author

Vazquez, Jose A, Arnold, Anthony C, Swanson, Robert N, Biswas, Pinaki, and Bassetti, Matteo

Subjects
linezolid, optic nerve diseases, oxazolidinones, peripheral nervous system diseases, safety, Oncology & Carcinogenesis, Public Health and Health Services
Abstract

ObjectiveThe objective of this study was to assess the long-term safety of linezolid in patients with chronic infections requiring treatment for ≥6 weeks. Enhanced monitoring for optic neuropathy was included to characterize the early development of this side effect and to identify ophthalmologic tests that might be valuable in early detection of this event.MethodsThis was a multicenter, open-label, pilot study of patients aged ≥18 years on long-term linezolid therapy. Matched control patients were included for baseline assessment comparison. Patients were assessed at study entry, monthly while on treatment, at the end of treatment, and 30 days following the last dose. Aggregate ocular safety data were reviewed. Response to treatment was reported.ResultsThe study was terminated owing to slow enrollment. Twenty-four patients received linezolid; nine patients were included as matched controls. Linezolid was prescribed for a median of 80.5 days (range, 50-254 days). In patients with a reported clinical outcome, the majority were considered improved or cured. Common treatment-related adverse events (AEs) included anemia, peripheral neuropathy, polyneuropathy, vomiting, and asthenia, and were consistent with the known safety profile. Most AEs resolved or stabilized with discontinuation of treatment. Results of ophthalmologic tests in the one case adjudicated as probable linezolid-associated optic neuropathy revealed abnormal color vision, characteristic changes in the optic disk, and central scotomas in each eye.ConclusionIn our small population, linezolid was generally well tolerated and AEs were consistent with the known safety profile. Extensive ophthalmologic testing of all 24 linezolid-treated patients identified one case adjudicated as probable, linezolid-associated optic neuropathy.

Published
2016

10. Aggressive Low-Grade Optic Nerve Glioma in Adults

Author

Bilgin, Gorkem, Al-Obailan, Majed, Bonelli, Laura, Glasgow, Ben J, Vinters, Harry V, and Arnold, Anthony C

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Ophthalmology and Optometry, Cancer, Brain Cancer, Rare Diseases, Eye Disease and Disorders of Vision, Neurosciences, Clinical Research, Brain Disorders, Eye, Adult optic glioma, ganglioglioma, pilocytic astrocytoma, WHO Grade I-II, WHO Grade I–II, Opthalmology and Optometry, Ophthalmology & Optometry, Ophthalmology and optometry, Biological psychology
Abstract

Primary optic nerve gliomas are most commonly benign pilocytic astrocytomas (World Health Organization [WHO] Grade I) occurring in childhood and following an indolent course. Malignant optic gliomas occur in adulthood and follow an extremely aggressive course, with rapid infiltration of the chiasm, blindness, and death typically within months. A third category of optic glioma, occurring in adulthood, histopathologically benign (WHO Grade I-II) but following an aggressive course, has been rarely reported. The authors describe clinical and histopathologic features of clinically aggressive but histopathologically benign optic nerve gliomas of adulthood. Retrospective review of cases of biopsy-proven optic nerve glioma in the neuro-ophthalmology division of the Jules Stein Eye Institute from 1990 to 2011 was carried out. Cases following an aggressive course were selected for review of clinical, neuroradiologic, and histopathologic features. Three cases were selected for detailed study. Ages ranged from 31 to 45 years. All were initially diagnosed with optic nerve inflammation or benign neoplasm based on clinical and neuroradiologic features, but all suffered neuroradiologic extension and rapid deterioration of vision in the affected eye to no light perception over 3-8 weeks. Optic nerve biopsies were undertaken for the suspicion of malignancy. Features ranged from WHO Grade I (pilocytic astrocytoma, ganglioglioma) in two cases, to WHO Grade II in one case (diffuse astrocytoma, histopathologically benign, but associated with aggressive features such as high p53 [13-21%] and Ki-67 [40%]). The diffuse astrocytoma case subsequently developed extensive intracranial extension suspicious for malignant transformation. These findings indicate that benign optic nerve glioma in adults may be initially misdiagnosed as inflammation, be clinically aggressive, and require excision to prevent further intracranial involvement.

Published
2014

18. OCT retinal nerve fiber layer thickness differentiates acute optic neuritis from MOG antibody-associated disease and Multiple Sclerosis

Author

Chen, John J., primary, Sotirchos, Elias S., additional, Henderson, Amanda D., additional, Vasileiou, Eleni S., additional, Flanagan, Eoin P., additional, Bhatti, M. Tariq, additional, Jamali, Sepideh, additional, Eggenberger, Eric R., additional, Dinome, Marie, additional, Frohman, Larry P., additional, Arnold, Anthony C., additional, Bonelli, Laura, additional, Seleme, Nicolas, additional, Mejia-Vergara, Alvaro J., additional, Moss, Heather E., additional, Padungkiatsagul, Tanyatuth, additional, Stiebel-Kalish, Hadas, additional, Lotan, Itay, additional, Hellmann, Mark A., additional, Hodge, Dave, additional, Oertel, Frederike Cosima, additional, Paul, Friedemann, additional, Saidha, Shiv, additional, Calabresi, Peter A., additional, and Pittock, Sean J., additional

Published
2022
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20. Contributors

Author

Abtahi, Maryam, Adams, Wendy, Afshari, Natalie A., Agarwal, Anita, Agranat, Joshua S., Ajlan, Radwan S., Akhlaq, Anam, Al-Aswad, Lama, AlBayyat, Ghada, Albini, Thomas A., Ghoul, Ahmed Al, Al-Mohtaseb, Zaina, Alvi, Nishat P., Apple, David J., Aquino, Maria Cecilia, Arnold, Anthony C., Arnoldi, Kyle, Arshinoff, Steve A., Asbell, Penny A., Ashe, Stephen A., Asroui, Lara, Atebara, Neal H., Awh, Katherine C., Aylward, G. William, Bacci, Tommaso, Bakri, Sophie J., Balcer, Laura J., Balducci, Nicole, Barboni, Piero, Baş, Zeynep, Basu, Soumyava, Baumal, Caroline R., Bessette, Angela P., Bhatt, Nirali, Bhullar, Paramjit K., Binotti, William, Birch, Eileen E., Biswas, Jyotirmay, Bjerregaard, Robert William, Bose, Swaraj, Bouchard, Charles S., Boulton, Michael E., Bouremel, Yann, Brandt, James D., Brocchini, Steve, Brodie, Scott E., Brodsky, Michael C., Brooks, Cassandra, Brown, Aaron Christopher, Budenz, Donald L., Cantor, Louis B., Capo, Hilda, Capone, Antonio, Jr., Carruthers, Alastair, Carruthers, Jean D., Carter, Keith D., Chahal, Harinderpal, Chan, Chi-Chao, Chan, Jane W., Chang, Melinda Y., Chang, Stanley, Charteris, David G., Chee, Soon-Phaik, Chen, Masako, Chen, Michael Yipeng, Chen, Sien, Chen, Xuejing, Tec Kuan Chew, Paul, Chong, Jillian K., Chow, Clement C., Clarke, Jonathan C.K., Codère, François, Conner, Ian P., Soledad Cortina, Maria, Couch, Steven M., Coupland, Stuart G., Cowan, Claude, Craven, E. Randy, Cukras, Catherine A., Dagi, Linda, Dalvin, Lauren A., Damgaard, Iben Bach, Fatehali Damji, Karim, Das, Dipankar, DeBusk, Adam, Carlo, Talisa E. de, Coulon, Sara Jacob, Demer, Joseph Louis, Desai, Shilpa J., Dhaliwal, Deepinder K., Dhawlikar, Nisha, Diamond, Gary R., Diaz, Jose Daniel, Diniz, Daniel, Djenderedjian, Levon, Do, Anna Thanh Tam, Do, Diana V., Dolman, Peter J., Donahue, Sean P., Drenser, Kimberly A., Duffy, Kevin R., Duker, Jacob S., Duker, Jay S., Dupps, William J., Jr., Durairaj, Vikram D., Dutton, Jonathan J., Eliott, Dean, Engelbert, Michael, Enzor, Rikki S., Epstein, Aliza, Evans, Joshua W., Evans, Monica, Faia, Lisa J., Fallano, Katherine A., Farjo, Ayad A., Fernandez, Karen B., Fisher, Yale L., Fortun, Jorge A., Friedman, Deborah I., Friedman, Neil J., Fynn-Thompson, Nicoletta, Gadaria-Rathod, Neha, Garg, Sumit (Sam), Gayre, Gregg, Gedde, Steven, Geevarghese, Alexi, Ghosh, Saurabh, William Gigantelli, James, Goerlitz-Jessen, Mark, Goldberg, Ivan, Goldberg, Jeffrey L., Goldstein, Debra A., Goldstein, Michael H., Gonzales, John A., Gore, Charlotte, Granet, David B., Greven, Craig M., Greven, Margaret A., Gross, Ronald L., Gündüz, Ahmet Kaan, Gupta, Preeya K., Haller, Julia A., Hamrah, Pedram, Hannush, Sadeer B., Hardin, Joshua S., Harris, Alon, Hassan, Muhammad, Heier, Jeffrey S., Herndon, Leon W., Ho, Allen C., Ho, Joanne W., Honasoge, Avinash, Hood, Christopher T., Houghton, Odette, Houser, Kourtney, Howes, Frank W., Hsu, Jason, Hurwitz, Jeffrey J., Irochima, Francisco, Isteitiya, Jihad, Iyer, Geetha, Izak, Andrea M., Jackson, Kevin, Jacob, Soosan, Jacoba, Cris Martin P., Jacobs, Deborah S., Jampel, Henry D., Jampol, Lee M., Jeng-Miller, Karen, Jing-Wei Chen, John, Johnson, Mark W., Johnson, T. Mark, Johnstone, Murray, Kaakour, Abdul-Hadi, Kaehr, Mark M., Kahook, Malik Y., Kaiser, Peter K., Kalafatis, Nicholas, Kalevar, Ananda, Kane, Steven, Kang, Kai, Kanner, Elliott M., Kapoor, Saloni, Alton Kapusta, Michael, Karanjia, Rustum, Kardon, Randy H., Karp, Carol L., Kashani, Amir H., Kass, Michael A., Kataguiri, Paula, Kaufman, Paul L., D. Keenan, Jeremy, Kelly, Elaine, Kenyon, Kenneth R., Khandelwal, Sumitra, Tee Khaw, Peng, Kim, Ivana K., Kim, Terry, Kinori, Michael, Kiss, Szilárd, Kitchens, John W., Klein, Kendra, Ko, Narae, Koch, Douglas D., Kodati, Shilpa, Koh, Victor, Kohnen, Thomas, Konstas, Angelos A., Koo, Ellen, Lane, Stephen S., Lavin, Patrick J.M., Lavinsky, Fabio, Lawton, Andrew W., Le, Nhon T., Lee, Bonny, Lee, Crystal, Lee, Gregory D., Lee, Paul P, Han Lee, Rachel, Ann Lim, Dawn Ka, Lin, Tony, Lind, John T., Liu, Dan, Liu, Yao, Liyanage, Sidath E., Longmuir, Reid A., Lundström, Mats, N. Maamari, Robi, Mahjoub, Heba, Maloney, Maya H., Mamalis, Christina, Manche, Edward E., Mandava, Naresh, Martheswaran, Tanisha, Masket, Samuel, Mattox, Cynthia, Kevin McClatchey, Scott, McLeod, Stephen D., McMillan, Brian D., McNab, Alan A., Mehra, Ankur, Mehta, Jodhbir S., Mejia-Vergara, Alvaro J., Mejico, Luis J., Mekhail, Joseph, N. Mercer, Ryan, Mian, Shahzad I., Mieler, William F., Miller, Kyle E., Mirza, Rukhsana G., Misra, Poonam, Mititelu, Mihai, Mohammed, Taariq, Moorthy, Ramana S., Morkin, Melina I., Moshfeghi, Andrew A., Moshirfar, Majid, Moss, Heather E., Moster, Mark L., Muhtaseb, Ruba, Muir, Kelly W., Neff, Ann G., Nerad, Jeffrey A., Ng, Caleb C., Nguyen, Annie, Nikpoor, Neda, Nosé, Ricardo, Okada, Annabelle A., Datoo O'Keefe, Ghazala A., Olson, Jeffrey L., Olver, Jane M., Örge, Faruk H., Packard, Richard, Packer, Mark, Panarelli, Joseph, Pandey, Suresh K., Parikh, Vishal S., Pasha, Hamza, Pasquale, Louis R., Patel, Palak, Patel, Sarju S., Patel, Shaila R., Patel, Vivek R., Pavesio, Carlos, Perez, Victor L., Phillips, Lauren T., Piltz-Seymour, Jody R., Piva, Alfio P., Presland, Andrew H., Price, Francis W., Price, Marianne O., Quiros, Peter A., Rachitskaya, Aleksandra, Rahmani, Safa, Ramulu, Pradeep Y., Randleman, J. Bradley, Rao, Narsing A., Rao, Naveen K., Rao, P. Kumar, Rao, Rajesh C., Rathinam, Sivakumar, Read, Russell W., Reed, Donovan, Vinícius Saito Regatieri, Caio, Regillo, Carl D., Reichel, Elias, Reighard, Chelsea L., Richard, Alyse, Ringeisen, Alexander, Ritch, Robert, Robbins, Shira L., M. Rocha, Karolinne, Rodger, Damien C., Roh, Miin, Rosado-Adames, Noel, Rowe, Lucas W., Rubenstein, Jonathan B., Rubin, Richard M., Rubsamen, Patrick E., Saadati, Hossein G., Sadun, Alfredo A., Saeedi, Osamah, Sajjad, Ahmar, Salchow, Daniel J., Salim, Sarwat, Salongcay, Recivall P., Sandhu, Simrenjeet, Santhiago, Marcony R., Satija, Celine E., M. Schallhorn, Julie, Schmitt, Melanie, Schor, Paulo, Schroeder, Richard, Schubert, Hermann D., Schuman, Joel S., Schwartz, Gary S., Sen, H. Nida, Shah, Gaurav K., Shah, Ravi, Shields, Carol L., Shields, Jerry A., Shildkrot, Yevgeniy (Eugene), Shingleton, Bradford J., Shtein, Roni M., Shu-Wen Chan, Nicole, Shultz, Ryan W., Sieck, Erin, Siesky, Brent, Sieving, Paul A., S. Silva, Paolo, Simmons, Kirsten, Skondra, Dimitra, Smiddy, William E., Somogyi, Marie, Soong, H. Kaz, Soukiasian, Sarkis H., Spoor, Thomas C., Srinivasan, Bhaskar, Srivastava, Sunil K., Starnes, Taylor W., Starr, Matthew R., Steel, David H., Steigleman, W. Allan, Stein, Joshua D., Stepien, Kimberly E., Stevens, Dylan V., Strominger, Mitchell B., Sugar, Alan, Sugar, Joel, Suh, Donny W., Sun, Michelle, Sun, Yang, Sychev, Yevgeniy V., Tai, Tania, Tan, James C., Tanenbaum, Myron, Tasman, William, Tassignon, Marie-José B., Testi, Ilaria, Thall, Edmond H., Thanos, Aristomenis, Theophanous, Christos N., Thornton, Sarah, Tingey, David P., Todorich, Bozho, Tompson, Stuart W., Toy, Brian, Tsai, James C., Tsai, Julie, Tucker, Nancy, Tuli, Sonal S., Valerio, Gabriel S., Vargason, Caroline W., Vasaiwala, Roshni A., Vitor Vasconcelos-Santos, Daniel, Vaughn, Gregory J., Venkateswaran, Nandini, Vinod, Kateki, Vislisel, Jesse M., Vrcek, Ivan, Walton, David S., Wang, Li, Wang, Michelle Y., Wang, Robert C., Waring IV, George O., Weikert, Mitchell P., Werner, Liliana, Wevill, Mark, Wiggs, Janey L., Williams, Andrew M., Williams, George A., Witmer, Matthew T., Wollstein, Gadi, Woodward, Maria A., Wride, Nicholas K., Wu, Albert Y., Yaghy, Antonio, Young, Joshua A., Zaguia, Fatma, Zein, Wadih M., and Zhu, Ivy

Published
2023
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24. List of Contributors

Author

Ahmed, Iqbal ike K., primary, Ahmed, Irma, additional, Ai, Everett, additional, Al-Ghoul, Ahmed, additional, Allen, David, additional, Alvi, Nishat P., additional, Anand, Rajiv, additional, Ang, Leonard P.-K., additional, Apple, David J., additional, Archer, Desmond B., additional, Arnold, Anthony C., additional, Arshinoff, Steve A., additional, Assil, Kerry K., additional, Atebara, Neal H., additional, Atluri, Harvinder K.S., additional, Augsburger, James J., additional, Aylward, G. William, additional, Azar, Dimitri T., additional, Baker, Brad J., additional, Balcer, Laura Joan, additional, Barnett, C.J., additional, Baumal, Caroline R., additional, Bearelly, Srilaxmi, additional, Benson, William E., additional, Berger, Steven Thomas, additional, Biswas, Jyotirmav, additional, Bolling, James P., additional, Bornfeld, Norbert, additional, Bose, Swaraj, additional, Bouchard, Charles S., additional, Boulton, Michael E., additional, Brandt, James D., additional, Brodsky, Michael C., additional, Brown, Kimberly Ellen, additional, Brown, Gary C., additional, Brown, Melissa M., additional, Budenz, Donald L., additional, Bui, Alex, additional, Burns, Stephen K., additional, Campolattaro, Brian N., additional, Cantor, Louis B., additional, Jr, Antonio Capone, additional, Carter, Keith D., additional, Chan, Chi-Chao, additional, Chang, Stanley, additional, Chao, Jennifer R., additional, Charonis, George C., additional, Chew, Paul T.K., additional, Ciardella, Antonio P., additional, Civan, Mortimer M., additional, Clark, Abbott F., additional, Clarke, Jonathan, additional, Contreras, Janice E., additional, Collin, J. Richard O., additional, Codère, François, additional, Corrêa, Zélia M., additional, Cowan, Claude L., additional, Craven, E. Randy, additional, Cruess, Alan F., additional, Custer, Phillip L., additional, Dahan, Elie, additional, Dai, Eric, additional, Damato, Bertil E., additional, Damji, Karim F., additional, Davidson, Richard S., additional, Davis, Elizabeth A., additional, Dhaliwal, Deepinder K., additional, Diamond, Gary R., additional, Do, Diana V., additional, Donahue, Sean P., additional, Dortzbach, Richard K., additional, Drenser, Kimberly A., additional, Duker, Jay S., additional, Dutton, Jonathan J., additional, Edgington, Bryan, additional, Eggers, Howard M., additional, Ehlers, William, additional, Engelbert, Michael, additional, Espandar, Ladan, additional, Evans, Monica, additional, Farjo, Ayad A., additional, Farjo, Qais Anastas, additional, Faucett, Donald C., additional, Feiz, Vahid, additional, Fine, I. Howard, additional, Fisher, Yale L., additional, Fishman, Gerald A., additional, Forster, David J., additional, Fox, Gregory M., additional, Freedman, Jeffrey, additional, Friedman, David S., additional, Friedman, Neil J., additional, Friedman, Deborah I., additional, Fu, Arthur D., additional, Fynn-Thompson, Nicoletta, additional, Ganatra, Jyotsom, additional, Gayre, Gregg S., additional, Gery, Igal, additional, Ghanem, Ramon C., additional, Giblin, Michael, additional, Gigantelli, James W., additional, Goldberg, Anna, additional, Goldberg, Robert A., additional, Goldberg, William, additional, Goldberg, Ivan, additional, Goldstein, Debra A., additional, Goldstein, Michael H., additional, Gonder, John R., additional, Green, Jeffrey P., additional, Greven, Craig M., additional, Gross, Nicole E., additional, Gross, Ronald L., additional, Grover, Sandeep, additional, Guercio, Jason R., additional, Gupta, Vishali, additional, Gupta, Amod, additional, Gurkan, Sevgi, additional, Guthoff, Rudolf E., additional, Hallak, Joelle, additional, Haller, Julia A., additional, Hamilton, Richard S., additional, Harbour, J. William, additional, Hardten, David R., additional, Harris, Alon, additional, Hedges Jr, Thomas R., additional, Heier, Jeffrey S., additional, Henderson, Polly A., additional, Herndon, Leon W., additional, Hitchings, Roger A., additional, Ho, Allen C., additional, Hoffman, Richard S., additional, Holz, Huck A., additional, Howard, Gene R., additional, Howes, Frank W., additional, Hsu, Jason, additional, Hurwitz, Jeffrey J., additional, Inomata, Hajime, additional, Ip, Michael, additional, Isaacs, Robert T., additional, Izak, Andrea M., additional, Jampel, Henry, additional, Jampol, Lee M., additional, Jiyamapa, Julia, additional, Johnson, Chris A., additional, Johnson, T. Mark, additional, Johnson, Mark W., additional, Jones, Nicholas, additional, Kahook, Malik, additional, Kanner, Elliott M., additional, Kapusta, Michael A., additional, Kardon, Randy, additional, Karp, Carol L., additional, Kass, Michael, additional, Katz, L. Jay, additional, Kaufman, Paul L., additional, Khan, Baseer, additional, Khaw, Peng Tee, additional, Kim, Gene, additional, Kimura, Alan E., additional, Kitzmann, Anna, additional, Klancnik, James M., additional, Koch, Douglas D., additional, Kohnen, Thomas, additional, Kojima, Takashi, additional, Kornmehl, Ernest W., additional, Kramarevsky, Natalia, additional, Labbe, Thad, additional, Lane, Stephen S., additional, Lavin, Patrick J.M., additional, Lawton, Andrew, additional, Lee, Paul P., additional, Leen, Martha Motuz, additional, Levinson, Ralph, additional, Lim, Ridia, additional, Lingua, Robert W., additional, Lipham, William J., additional, Lopez, Pedro F., additional, Lundstrom, Mats, additional, Magnante, Peter, additional, Mandava, Naresh, additional, Marak, George E., additional, Marmor, Michael F., additional, Marten, Lisa, additional, Mathura, Jeevan R., additional, Martidis, Adam, additional, Mattox, Cynthia, additional, McDermott, Mark L., additional, McLeod, Stephen D., additional, Mejico, Luis J., additional, Meyers, Sanford M., additional, Mieler, William F., additional, Migdal, Clive S., additional, Miller, David, additional, Miller, Russell, additional, Mimura, Tatsuya, additional, Mittra, Robert A., additional, Moorthy, Ramana S., additional, Morley, Michael G., additional, Morse, Lawrence S., additional, Moshirfar, Majid, additional, Moster, Mark L., additional, Nehls Rikkers, Sarah M., additional, Neff, Ann G., additional, Newlin, Anna C., additional, Noble, Kenneth G., additional, Noecker, Robert J., additional, Okada, Annabelle A., additional, Olson, Jeffrey L., additional, Opalinski, Yvonne A.V., additional, Packer, Mark, additional, Pandey, Suresh K., additional, Patel, Vivek Ravindra, additional, Pavesio, Carlos E., additional, Pineles, Stacy, additional, Piva, Alfio, additional, Piltz-Seymour, Jody, additional, Pollack, John S., additional, Prall, F. Ryan, additional, Price, Marianne O., additional, Price, Francis W., additional, Primack, Jonathan D., additional, Pruett, Ronald C., additional, Puliafito, Carmen A., additional, Pulido, Jose S., additional, Quiros, Peter A., additional, Ramulu, Pradeep, additional, Ramos-Esteban, Jerome C., additional, Rao, P. Kumar, additional, Rao, Narsing A., additional, Read, Russell W., additional, Rechtman, Ehud, additional, Regillo, Carl D., additional, Reichel, Elias, additional, Rhee, Douglas J., additional, Rhee, Steven S., additional, Rheinstrom, Stephen D., additional, Riedel, Patrick J., additional, Rikkers, Sarah M., additional, Robinson, Fiona O., additional, Rodriguez-Coleman, Hannah, additional, Rogers, Adam, additional, Roe, Richard, additional, Roh, Shiyoung, additional, Rosen, Emanuel S., additional, Rosenblatt, Brett, additional, Rosenfeld, Philip J., additional, Rubenstein, Jonathan B., additional, Rubin, Steven E., additional, Rubin, Richard M., additional, Rubsamen, Patrick E., additional, Saadati, Hossein G., additional, Sadun, Alfredo A., additional, Salim, Sarwat, additional, Salinas, Humberto, additional, Samuelson, Thomas W., additional, Sanborn, George E., additional, Sarmiento, Jerome S., additional, Scheufele Cleary, Tina A., additional, Schor, Paulo, additional, Schubert, Hermann D., additional, Schuman, Joel, additional, Schwab, Ivan R., additional, Schwartz, Gary S., additional, Scott, Clifford A., additional, Sebag, Jerry, additional, See, Jovina L.S., additional, Selkin, Robert P., additional, Shields, Bruce, additional, Shingleton, Bradford, additional, Sierra, Patricia B., additional, Sieving, Paul A., additional, Sivalingam, Arunan, additional, Small, Kent W., additional, Smiddy, William E., additional, Soong, Kaz, additional, Soukiasian, Sarkis, additional, Spaide, Richard F., additional, Spoor, Thomas C., additional, Stasi, Kalliopi, additional, Steel, David, additional, Stein, Joshua D., additional, Steinemann, Thomas L., additional, Suchecki, Jeanine, additional, Sugar, Joel, additional, Sugar, Alan, additional, Tan, J.C.H., additional, Tanenbaum, Myron, additional, Taravella, Michael J., additional, Tasman, William S., additional, Telander, David G., additional, Tennant, Matthew T.S., additional, Tessler, Howard H., additional, Thall, Edmond H., additional, Tingey, David P., additional, Tobaigy, Faisal M., additional, Truong, Steven, additional, Tsai, James C., additional, Tsai, Julie, additional, Tsiaras, William G., additional, Tu, Elmer Y., additional, Tucker, Nancy, additional, Tuli, Sonal S., additional, Valluri, Shailaja, additional, Vander, James F., additional, Vaughn, Gregory J., additional, Virasch, Vanee Val, additional, Wadia, Hormuz P., additional, Walker, Rebecca S., additional, Walton, David Sellers, additional, Wang, Li, additional, Wang, Frederick M., additional, Wang, Ming X., additional, Wang, Robert C., additional, Wax, Martin, additional, Weinberg, David V., additional, Weinstein, Joel M., additional, Weiter, John J., additional, Werner, Liliana, additional, Wevill, Mark T., additional, White, Paul F., additional, Wiggs, Janey L., additional, Wilkinson, Charles P., additional, Williams, Patrick D., additional, Williams, George A., additional, Wirostko, William J., additional, Wollstein, Gadi, additional, Yee, Robert D., additional, Young, Joshua A., additional, and Zamir, Ehud, additional

Published
2009
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33. Reply

Author

Chang, Melinda Y., primary, Velez, Federico G., additional, Demer, Joseph L., additional, Bonelli, Laura, additional, Quiros, Peter A., additional, Arnold, Anthony C., additional, Sadun, Alfredo A., additional, and Pineles, Stacy L., additional

Published
2018
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35. Colaboradores

Author

Acera, Erika C., Afshari, Natalie A., Agarwal, Anita, Agranat, Joshua S., Ajlan, Radwan S., Akhlaq, Anam, Albini, Thomas A., Al-Ghoul, Ahmed, Ali, Ferhina S., Alió, Jorge L., Allemann, Norma, Allen, David, Allman, Keith G., Alvi, Nishat P., Ang, Leonard P.K., Apple, David J., Aquino, Maria Cecilia D., Arnold, Anthony C., Arshinoff, Steve A., Asbell, Penny A., Assil, Kerry K., Atebara, Neal H., Augsburger, James J., Aylward, G. William, Azar, Dimitri T., Bakri, Sophie J., Balcer, Laura J., Balducci, Nicole, Barboni, Piero, Barnett, Cullen J., Basu, Soumyava, Batta, Priti, Baumal, Caroline R., Bearelly, Srilaxmi, Berry, Jesse L., Bessette, Angela P., Bhatt, Nirali, Birdsong, Orry C., Biswas, Jyotirmay, Bodaghi, Bahram, Bose, Swaraj, Bouchard, Charles S., Boulton, Michael E., Brandt, James D., Brodie, Scott E., Brodsky, Michael C., Brooks, Cassandra C., Brumm, Matthew V., Budenz, Donald L., Bussel, Igor I., Cantor, Louis B., Capó, Hilda, Capone, Antonio, Jr., Carruthers, Alastair, Carruthers, Jean, Carter, Keith D., Caruso, Rafael C., Chahal, Harinderpal S., Chamon, Wallace, Chan, Chi-Chao, Chang, Melinda Y., Chang, Stanley, Chang, Victoria S., Charteris, David G., Chee, Soon-Phaik, Chen, John J., Chen, Xuejing, Chew, Paul T.K., Chiu, Bing, Chow, Clement C., Civan, Mortimer M., Clark, Abbot (Abe), Clarke, Jonathan C.K., Codère, François, Conner, Ian P., Coombs, Peter, Corrêa, Zélia M., Couch, Steven M., Coupland, Stuart G., Cowan, Claude L., Jr., Craven, E. Randy, Cukras, Catherine A., Dagi, Linda R., Dahan, Elie, Damgaard, Iben Bach, Damji, Karim F., Das, Dipankar, DeBusk, Adam, de la Cruz, Jose, Demer, Joseph L., Desai, Shilpa J., Dhaliwal, Deepinder K., Diamond, Gary R., Diniz, Daniel, Do, Diana V., Dolman, Peter J., Donahue, Sean P., Dortzbach, Richard K., Drenser, Kimberly A., Duker, Jacob S., Duker, Jay S., Durairaj, Vikram D., Dutton, Jonathan J., Edgington, Bryan, Eggers, Howard M., Eliott, Dean, Ellis, George S., Jr., Engelbert, Michael, Englander, Miriam, Esmaeli, Bita, Evans, Joshua W., Evans, Monica, Fahd, Daoud S., Faia, Lisa J., Fallano, Katherine A., Farjo, Ayad A., Feinstein, Eric, Fernandez, Karen B., Fisher, Yale L., Fishman, Gerald A., Fortun, Jorge A., Fragoso, Veronica Vargas, Freeman, Nicola, Friedman, David S., Friedman, Deborah I., Friedman, Neil J., Fynn-Thompson, Nicoletta, Gadaria-Rathod, Neha, Garcia-Zalisnak, Debora E., Gayre, Gregg S., Gedde, Steven J., Gery, Igal, Ghanem, Ramon C., Ghanem, Vinícius C., Ghosh, Saurabh, Gibbons, Allister, Gigantelli, James W., Giri, Pushpanjali, Goldberg, Ivan, Goldberg, Jeffrey L., Goldstein, Debra A., Goldstein, Michael H., Gonzales, John A., Granet, David B., Gray, Matthew J., Green, Kyle M., Greven, Craig M., Greven, Margaret A., Gross, Josh C., Gross, Ronald L., Grover, Sandeep, Guercio, Jason R., Gueudry, Julie, Gündüz, Ahmet Kaan, Hallak, Joelle A., Haller, Julia A., Hamrah, Pedram, Hardten, David R., Harris, Alon, Heier, Jeffrey S., Herndon, Leon W., Jr., Ho, Allen C., Hood, Christopher T., Hou, Joshua H., Houghton, Odette M., Houser, Kourtney, Howes, Frank W., Hsu, Jason, Hurwitz, Jeffrey J., Irochima, Francisco, Isteitiya, Jihad, Izak, Andrea M., Jacobs, Deborah S., Jain, Sandeep, Jampel, Henry D., Jampol, Lee M., Jap, Aliza, Johnson, Chris A., Johnson, Mark W., Johnson, T. Mark, Kaehr, Mark M., Kahook, Malik Y., Kaiser, Peter K., Kalarn, Sachin P., Kalevar, Ananda, Kane, Steven, Kanner, Elliott M., Kaplowitz, Kevin, Kapusta, Michael A., Karanjia, Rustum, Kardon, Randy H., Karp, Carol L., Kashani, Amir H., Kass, Michael A., Kataguiri, Paula, Katz, L. Jay, Kaufman, Paul L., Keenan, Jeremy D., Kenyon, Kenneth R., Khaw, Sir Peng Tee, Kim, Gene, Kim, Ivana K., Kimura, Alan E., Kinori, Michael, Kirwan, Caitriona, Kiss, Szilárd, Kitchens, John W., Klein, Kendra, Koch, Douglas D., Koh, Victor T.C., Kohnen, Thomas, Koustenis, Andrew, Lane, Stephen S., Lavin, Patrick J.M., Lavinsky, Fabio, Lawton, Andrew W., Lee, Bryan S., Lee, Daniel, Lee, Gregory D., Lee, Olivia L., Lee, Paul P., Lee, Richard M.H., Lim, Dawn K.A., Lim, Jennifer I., Lim, Ridia, Lin, Tony K.Y., Lind, John T., Liu, Yao, Liyanage, Sidath E., Lockwood, Alastair J., Loewen, Nils A., Longmuir, Reid A., Lopez, Pedro F., Lundström, Mats, Maamari, Robi N., Madu, Assumpta, Maloney, Maya H., Mandava, Naresh, Marmor, Michael F., Mathura, Jeevan R., Jr., Mattox, Cynthia, McClatchey, Scott K., McLeod, Stephen D., McMillan, Brian D., McNab, Alan A., Mehta, Jodhbir S., Mejico, Luis J., Mercado, Carolina L., Mian, Shahzad I., Mieler, William F., Miller, David, Miller, Kyle E., Mimura, Tatsuya, Mirza, Rukhsana G., Mititelu, Mihai, Moorthy, Ramana S., Moshfeghi, Andrew A., Moshirfar, Majid, Moss, Heather E., Moster, Mark L., Muir, Kelly W., Neff, Ann G., Nerad, Jeffrey A., Nikpoor, Neda, Noecker, Robert J., Nosé, Ricardo, Okada, Annabelle A., O’Keefe, Michael, Olson, Jeffrey L., Olver, Jane M., Opalinski, Yvonne A.V., Örge, Faruk H., Packer, Mark, Pandey, Suresh K., Parikh, Vishal S., Pasquale, Louis R., Patel, Sarju S., Patel, Vivek R., Pavesio, Carlos E., Perez, Victor L., Perez-Straziota, Claudia E., Phillips, Lauren T., Piltz-Seymour, Jody R., Piva, Alfio P., Podbielski, Dominik W., Pondelis, Nicolas J., Price, Francis W., Jr., Price, Marianne O., Pritchard, Cindy, Quiros, Peter A., Rachitskaya, Aleksandra V., Ramulu, Pradeep Y., Randleman, J. Bradley, Rao, Narsing A., Rao, Naveen K., Rao, P. Kumar, Rao, Rajesh C., Rathinam, Sivakumar, Read, Russell W., Regatieri, Caio Vinicius Saito, Regillo, Carl D., Reichel, Elias, Rhee, Douglas J., Ringeisen, Alexander L., Ritch, Robert, Robbins, Shira L., Rodger, Damien C., Roh, Miin, Roh, Shiyoung, Rosado-Adames, Noel, Rosen, Emanuel S., Rubenstein, Jonathan B., Rubin, Richard M., Rubin, Steven E., Rubsamen, Patrick E., Rupp, Jason D., Saadati, Hossein G., Sadun, Alfredo A., Saeedi, Osamah J., Salchow, Daniel J., Salim, Sarwat, Samuelson, Thomas W., Sandhu, Simrenjeet, Santhiago, Marcony R., Savini, Giacomo, Sayed-Ahmed, Ibrahim O., Scheffler, Amy C., Schor, Paulo, Schubert, Hermann D., Schuman, Joel S., Schwartz, Gary S., Sebag, J., Sebrow, Dov B., Sen, H. Nida, Shah, Gaurav K., Shields, Carol L., Shildkrot, Yevgeniy (Eugene), Shingleton, Bradford J., Shtein, Roni M., Shultz, Ryan W., Sierra, Patricia B., Siesky, Brent, Sieving, Paul A., Skondra, Dimitra, Small, Kent W., Smiddy, William E., Somogyi, Marie, Soong, H. Kaz, Soukiasian, Sarkis H., Spaide, Richard F., Spektor, Tatyana, Spoor, Thomas C., Srivastava, Sunil K., Stagg, Brian C., Steel, David H.W., Stein, Joshua D., Strominger, Mitchell B., Sugar, Alan, Sugar, Joel, Sychev, Yevgeniy V., Tai, Tak Yee Tania, Tan, James C., Tanenbaum, Myron, Taneri, Suphi, Tasman, William, Telander, David G., Thall, Edmond H., Thanos, Aristomenis, Theophanous, Christos N., Thomas, Benjamin J., Thulasi, Praneetha, Tibbetts, Michael D., Tingey, David P., Tobaigy, Faisal M., Todorich, Bozho, Tompson, Stuart W., Tsai, James C., Tsai, Julie H., Tucker, Nancy, Tuli, Sonal S., Vargason, Caroline W., Vasaiwala, Roshni A., Vasconcelos-Santos, Daniel Vitor, Vaughn, Gregory J., Venkat, Arthi, Villarreal, Guadalupe, Jr., Vinod, Kateki, Vislisel, Jesse M., Vrcek, Ivan, Wadia, Hormuz P., Walker, Brian D., Walton, David S., Wang, Li, Wang, Michelle Y., Wang, Robert C., Wax, Martin, Weinstein, Joel M., Weiter, John J., Werner, Liliana, Wevill, Mark, Wiggs, Janey L., Williams, Andrew M., Williams, George A., Witmer, Matthew T., Wollstein, Gadi, Woodward, Maria A., Wride, Nicholas K., Wu, Albert, Xu, David, Young, Joshua A., Yung, Edward S., Yu-Wai-Man, Cynthia, Zein, Wadih M., and Zhu, Ivy

Published
2020
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41. List of Contributors

Author

Acera, Erika C., Afshari, Natalie A., Agarwal, Anita, Agranat, Joshua S., Ajlan, Radwan S., Akhlaq, Anam, Albini, Thomas A., Al-Ghoul, Ahmed, Ali, Ferhina S., Alió, Jorge L., Allemann, Norma, Allen, David, Allman, Keith G., Alvi, Nishat P., Ang, Leonard P.K., Apple, David J., Aquino, Maria Cecilia D., Arnold, Anthony C., Arshinoff, Steve A., Asbell, Penny A., Assil, Kerry K., Atebara, Neal H., Augsburger, James J., Aylward, G. William, Azar, Dimitri T., Bakri, Sophie J., Balcer, Laura J., Balducci, Nicole, Barboni, Piero, Barnett, Cullen J., Basu, Soumyava, Batta, Priti, Baumal, Caroline R., Bearelly, Srilaxmi, Berry, Jesse L., Bessette, Angela P., Bhatt, Nirali, Birdsong, Orry C., Biswas, Jyotirmay, Bodaghi, Bahram, Bose, Swaraj, Bouchard, Charles S., Boulton, Michael E., Brandt, James D., Brodie, Scott E., Brodsky, Michael C., Brooks, Cassandra C., Brumm, Matthew V., Budenz, Donald L., Bussel, Igor I., Cantor, Louis B., Capó, Hilda, Capone, Antonio, Jr, Carruthers, Alastair, Carruthers, Jean, Carter, Keith D., Caruso, Rafael C., Chahal, Harinderpal S., Chamon, Wallace, Chan, Chi-Chao, Chang, Melinda Y., Chang, Stanley, Chang, Victoria S., Charteris, David G., Chee, Soon-Phaik, Chen, John J., Chen, Xuejing, Chew, Paul T.K., Chiu, Bing, Chow, Clement C., Civan, Mortimer M., Clark, Abbot (Abe), Clarke, Jonathan C.K., Codère, François, Conner, Ian P., Coombs, Peter, Corrêa, Zélia M., Couch, Steven M., Coupland, Stuart G., Cowan, Claude L., Jr, Craven, E. Randy, Cukras, Catherine A., Dagi, Linda R., Dahan, Elie, Damgaard, Iben Bach, Damji, Karim F., Das, Dipankar, DeBusk, Adam, de la Cruz, Jose, Demer, Joseph L., Desai, Shilpa J., Dhaliwal, Deepinder K., Diamond, Gary R., Diniz, Daniel, Do, Diana V., Dolman, Peter J., Donahue, Sean P., Dortzbach, Richard K., Drenser, Kimberly A., Duker, Jacob S., Duker, Jay S., Durairaj, Vikram D., Dutton, Jonathan J., Edgington, Bryan, Eggers, Howard M., Eliott, Dean, Ellis, George S., Jr, Engelbert, Michael, Englander, Miriam, Esmaeli, Bita, Evans, Joshua W., Evans, Monica, Fahd, Daoud S., Faia, Lisa J., Fallano, Katherine A., Farjo, Ayad A., Feinstein, Eric, Fernandez, Karen B., Fisher, Yale L., Fishman, Gerald A., Fortun, Jorge A., Fragoso, Veronica Vargas, Freeman, Nicola, Friedman, David S., Friedman, Deborah I., Friedman, Neil J., Fynn-Thompson, Nicoletta, Gadaria-Rathod, Neha, Garcia-Zalisnak, Debora E., Gayre, Gregg S., Gedde, Steven J., Gery, Igal, Ghanem, Ramon C., Ghanem, Vinícius C., Ghosh, Saurabh, Gibbons, Allister, Gigantelli, James W., Giri, Pushpanjali, Goldberg, Ivan, Goldberg, Jeffrey L., Goldstein, Debra A., Goldstein, Michael H., Gonzales, John A., Granet, David B., Gray, Matthew J., Green, Kyle M., Greven, Craig M., Greven, Margaret A., Gross, Josh C., Gross, Ronald L., Grover, Sandeep, Guercio, Jason R., Gueudry, Julie, Gündüz, Ahmet Kaan, Hallak, Joelle A., Haller, Julia A., Hamrah, Pedram, Hardten, David R., Harris, Alon, Heier, Jeffrey S., Herndon, Leon W., Jr, Ho, Allen C., Hood, Christopher T., Hou, Joshua H., Houghton, Odette M., Houser, Kourtney, Howes, Frank W., Hsu, Jason, Hurwitz, Jeffrey J., Irochima, Francisco, Isteitiya, Jihad, Izak, Andrea M., Jacobs, Deborah S., Jain, Sandeep, Jampel, Henry D., Jampol, Lee M., Jap, Aliza, Johnson, Chris A., Johnson, Mark W., Johnson, T. Mark, Kaehr, Mark M., Kahook, Malik Y., Kaiser, Peter K., Kalarn, Sachin P., Kalevar, Ananda, Kane, Steven, Kanner, Elliott M., Kaplowitz, Kevin, Kapusta, Michael A., Karanjia, Rustum, Kardon, Randy H., Karp, Carol L., Kashani, Amir H., Kass, Michael A., Kataguiri, Paula, Katz, L. Jay, Kaufman, Paul L., Keenan, Jeremy D., Kenyon, Kenneth R., Khaw, Peng Tee, Kim, Gene, Kim, Ivana K., Kimura, Alan E., Kinori, Michael, Kirwan, Caitriona, Kiss, Szilárd, Kitchens, John W., Klein, Kendra, Koch, Douglas D., Koh, Victor T.C., Kohnen, Thomas, Koustenis, Andrew, Lane, Stephen S., Lavin, Patrick J.M., Lavinsky, Fabio, Lawton, Andrew W., Lee, Bryan S., Lee, Daniel, Lee, Gregory D., Lee, Olivia L., Lee, Paul P., Lee, Richard M.H., Lim, Dawn K.A., Lim, Jennifer I., Lim, Ridia, Lin, Tony K.Y., Lind, John T., Liu, Yao, Liyanage, Sidath E., Lockwood, Alastair J., Loewen, Nils A., Longmuir, Reid A., Lopez, Pedro F., Lundström, Mats, Maamari, Robi N., Madu, Assumpta, Maloney, Maya H., Mandava, Naresh, Marmor, Michael F., Mathura, Jeevan R., Jr, Mattox, Cynthia, McClatchey, Scott K., McLeod, Stephen D., McMillan, Brian D., McNab, Alan A., Mehta, Jodhbir S., Mejico, Luis J., Mercado, Carolina L., Mian, Shahzad I., Mieler, William F., Miller, David, Miller, Kyle E., Mimura, Tatsuya, Mirza, Rukhsana G., Mititelu, Mihai, Moorthy, Ramana S., Moshfeghi, Andrew A., Moshirfar, Majid, Moss, Heather E., Moster, Mark L., Muir, Kelly W., Neff, Ann G., Nerad, Jeffrey A., Nikpoor, Neda, Noecker, Robert J., Nosé, Ricardo, Okada, Annabelle A., O'Keefe, Michael, Olson, Jeffrey L., Olver, Jane M., Opalinski, Yvonne A.V., Örge, Faruk H., Packer, Mark, Pandey, Suresh K., Parikh, Vishal S., Pasquale, Louis R., Patel, Sarju S., Patel, Vivek R., Pavesio, Carlos E., Perez, Victor L., Perez-Straziota, Claudia E., Phillips, Lauren T., Piltz-Seymour, Jody R., Piva, Alfio P., Podbielski, Dominik W., Pondelis, Nicolas J., Price, Francis W., Jr, Price, Marianne O., Pritchard, Cindy, Quiros, Peter A., Rachitskaya, Aleksandra V., Ramulu, Pradeep Y., Randleman, J. Bradley, Rao, Narsing A., Rao, Naveen K., Rao, P. Kumar, Rao, Rajesh C., Rathinam, Sivakumar, Read, Russell W., Saito Regatieri, Caio Vinicius, Regillo, Carl D., Reichel, Elias, Rhee, Douglas J., Ringeisen, Alexander L., Ritch, Robert, Robbins, Shira L., Rodger, Damien C., Roh, Miin, Roh, Shiyoung, Rosado-Adames, Noel, Rosen, Emanuel S., Rubenstein, Jonathan B., Rubin, Richard M., Rubin, Steven E., Rubsamen, Patrick E., Rupp, Jason D., Saadati, Hossein G., Sadun, Alfredo A., Saeedi, Osamah J., Salchow, Daniel J., Salim, Sarwat, Samuelson, Thomas W., Sandhu, Simrenjeet, Santhiago, Marcony R., Savini, Giacomo, Sayed-Ahmed, Ibrahim O., Scheffler, Amy C., Schor, Paulo, Schubert, Hermann D., Schuman, Joel S., Schwartz, Gary S., Sebag, J., Sebrow, Dov B., Sen, H. Nida, Shah, Gaurav K., Shields, Carol L., Shildkrot, Yevgeniy (Eugene), Shingleton, Bradford J., Shtein, Roni M., Shultz, Ryan W., Sierra, Patricia B., Siesky, Brent, Sieving, Paul A., Skondra, Dimitra, Small, Kent W., Smiddy, William E., Somogyi, Marie, Soong, H. Kaz, Soukiasian, Sarkis H., Spaide, Richard F., Spektor, Tatyana, Spoor, Thomas C., Srivastava, Sunil K., Stagg, Brian C., Steel, David H.W., Stein, Joshua D., Strominger, Mitchell B., Sugar, Alan, Sugar, Joel, Sychev, Yevgeniy V., Tania Tai, Tak Yee, Tan, James C., Tanenbaum, Myron, Taneri, Suphi, Tasman, William, Telander, David G., Thall, Edmond H., Thanos, Aristomenis, Theophanous, Christos N., Thomas, Benjamin J., Thulasi, Praneetha, Tibbetts, Michael D., Tingey, David P., Tobaigy, Faisal M., Todorich, Bozho, Tompson, Stuart W., Tsai, James C., Tsai, Julie H., Tucker, Nancy, Tuli, Sonal S., Vargason, Caroline W., Vasaiwala, Roshni A., Vasconcelos-Santos, Daniel Vitor, Vaughn, Gregory J., Venkat, Arthi, Villarreal, Guadalupe, Jr, Vinod, Kateki, Vislisel, Jesse M., Vrcek, Ivan, Wadia, Hormuz P., Walker, Brian D., Walton, David S., Wang, Li, Wang, Michelle Y., Wang, Robert C., Wax, Martin, Weinstein, Joel M., Weiter, John J., Werner, Liliana, Wevill, Mark, Wiggs, Janey L., Williams, Andrew M., Williams, George A., Witmer, Matthew T., Wollstein, Gadi, Woodward, Maria A., Wride, Nicholas K., Wu, Albert, Xu, David, Young, Joshua A., Yung, Edward S., Yu-Wai-Man, Cynthia, Zein, Wadih M., and Zhu, Ivy

Published
2019
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47. The Spectrum of Optic Disc Ischemia in Patients Younger than 50 Years (An Amercian Ophthalmological Society Thesis)

Author

Arnold, Anthony C., Costa, Roberta M. S., and Dumitrascu, Oana M.

Subjects
Adult, Male, Adolescent, Articles, Kaplan-Meier Estimate, Middle Aged, Young Adult, Logistic Models, Risk Factors, Disease Progression, Humans, Kidney Failure, Chronic, Female, Optic Neuropathy, Ischemic, Fluorescein Angiography, Retrospective Studies
Abstract

To identify the spectrum of clinical and fluorescein angiographic features of optic disc ischemia in patients younger than 50 years.This retrospective comparative case series from a university consultative neuro-ophthalmology practice consisted of two phases. The first compared 108 cases of nonarteritic anterior ischemic optic neuropathy in patients younger than 50 years (NAIONy) to a cohort of 108 cases in patients 50 years or older (NAIONo). Predisposing risk factors, fluorescein angiographic features, and clinical course were compared. In the second phase, 12 cases of diabetic papillopathy under age 50 were assessed by fluorescein angiographic criteria for evidence of optic disc ischemia and compared to patients with NAIONy.NAIONy comprised 108 (12.7%) of 848 NAION cases reviewed. Chronic renal failure with dialysis and migraine were more common in NAIONy. Fellow eye involvement rate was significantly higher for NAIONy patients (46/108, 42.6%) than for NAIONo patients (32/108, 29.6%). Fluorescein angiographic features of ischemia were documented in 44 (81.5%) of 54 eyes studied. In one case, these features were documented in pre-NAION edema. Diabetic papillopathy demonstrated delayed filling consistent with ischemia in 7 of 10 (70.0%), without significant visual field loss.Ischemic optic neuropathy in patients younger than 50 years is not rare. Fellow eye involvement is more frequent in younger patients. Fluorescein angiography confirmation of impaired perfusion in multiple syndromes of optic neuropathy corroborates a spectrum of optic disc ischemia ranging from perfusion delay without visual loss to severely impaired perfusion and visual loss and incorporates optic neuropathies previously considered nonischemic.

Published
2013

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