18 results on '"Arnaud Lemière"'
Search Results
2. Dispersion-Engineered Step-Index Tellurite Fibers for Mid-Infrared Coherent Supercontinuum Generation from 1.5 to 4.5 μm with Sub-Nanojoule Femtosecond Pump Pulses
- Author
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Paul Froidevaux, Arnaud Lemière, Bertrand Kibler, Frédéric Désévédavy, Pierre Mathey, Grégory Gadret, Jean-Charles Jules, Kenshiro Nagasaka, Takenobu Suzuki, Yasutake Ohishi, and Frédéric Smektala
- Subjects
optical fibers ,tellurite glasses ,supercontinuum generation ,nonlinear optics ,mid-infrared light sources ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Mid-infrared supercontinuum generation from 1.5 to 4.5 µm with sub-nanojoule femtosecond pump pulses is demonstrated by using a short segment of dispersion-engineered step-index tellurite fiber with very low OH content. Distinct group-velocity dispersion regimes in a simple design of step-index tellurite fiber are also reported, which allows to choose the nonlinear pulse propagation regime according to the required tailoring of the supercontinuum source. Numerical simulations based on the generalized nonlinear Schrödinger equation are used to determine optimized fiber parameters before experimental demonstrations. We also analyse the coherence properties of the resulting supercontinuum sources.
- Published
- 2018
- Full Text
- View/download PDF
3. 2-18 μm mid-infrared supercontinuum generation in a step-index chalcogenide fiber
- Author
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Arnaud Lemière, Rémi Bizot, Frédéric Désévédavy, Grégory Gadret, Jean-Charles Jules, Pierre Mathey, Bertrand Kibler, and Frédéric Smektala
- Published
- 2022
4. 1.7–18 µm mid-infrared supercontinuum generation in a dispersion-engineered step-index chalcogenide fiber
- Author
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Christophe Aquilina, Arnaud Lemière, Grégory Gadret, Pierre Mathey, Rémi Bizot, Olivier Faucher, Frédéric Smektala, Franck Billard, Frédéric Désévédavy, Pierre Béjot, Jean-Charles Jules, Bertrand Kibler, Laboratoire Interdisciplinaire Carnot de Bourgogne [Dijon] (LICB), and Université de Bourgogne (UB)-Université de Technologie de Belfort-Montbeliard (UTBM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Optical fiber ,Materials science ,Nonlinear optics ,Chalcogenide glasses ,Chalcogenide ,QC1-999 ,Mid infrared ,General Physics and Astronomy ,02 engineering and technology ,01 natural sciences ,law.invention ,chemistry.chemical_compound ,law ,0103 physical sciences ,Dispersion (optics) ,Optical fibers ,Fiber ,Supercontinuum ,ComputingMilieux_MISCELLANEOUS ,Mid-infrared ,010302 applied physics ,[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics] ,business.industry ,Physics ,021001 nanoscience & nanotechnology ,Transmission (telecommunications) ,chemistry ,Optoelectronics ,0210 nano-technology ,business - Abstract
We demonstrate 1.7–18 µm mid-infrared coherent supercontinuum generation by means of the full transmission window of a unique dispersion-engineered step-index Ge-Se-Te fiber. Our study thus opens the entire molecular fingerprint region to future chalcogenide fiber platforms.
- Published
- 2021
5. Effect of post-heat-treatment on the structural, spectroscopic and dissolution properties of a highly stable Er3+-doped multi-component phosphate glass
- Author
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Nadia Giovanna Boetti, Laeticia Petit, Alexander Veber, Arnaud Lemière, and Diego Pugliese
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Materials science ,Scanning electron microscope ,Analytical chemistry ,Hydrochloric acid ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,law.invention ,Phosphate glass ,chemistry.chemical_compound ,law ,heat-treatment ,Materials Chemistry ,Spectroscopy ,Dissolution ,Glass-ceramic ,nucleation and growth ,Mechanical Engineering ,Doping ,Metals and Alloys ,glass-ceramic ,dissolution test ,021001 nanoscience & nanotechnology ,Er3+ luminescence property ,0104 chemical sciences ,chemistry ,Polymerization ,Mechanics of Materials ,0210 nano-technology - Abstract
In this paper, the impact of the post-heat-treatment on the structural and spectroscopic properties as well as on the chemical durability of a thermally stable Er3+-doped phosphate glass in the system P2O5 - K2O - Al2O3 - B2O3 - BaO - PbO - La2O3 - Gd2O3 is reported. Two crystalline phases, namely La, Gd-monazite and AlKP2O7, were found to precipitate from the surface of the glass after heat-treatment, as confirmed by both X-ray Diffraction (XRD) and Scanning Electron Microscopy/Energy Dispersive X-ray (SEM/EDX) analyses. Moreover, the heat-treatment was responsible for the formation of a more polymerized glass network close to the surface crystalline layer as evidenced using micro-Raman spectroscopy. From the changes in the Er3+ optical properties, some of the Er3+ ions are suspected to enter in the crystals. Both the as-prepared and heat-treated glasses were subjected to a degradation test in hydrochloric acid (HCl) and showed a congruent and incongruent dissolution behavior, respectively.
- Published
- 2021
6. Review of tellurite glasses purification issues for mid‐IR optical fiber applications
- Author
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Arnaud Lemière, Frédéric Désévédavy, Bertrand Kibler, Pierre Mathey, Jean-Charles Jules, Clément Strutynski, Frédéric Smektala, Grégory Gadret, Laboratoire Interdisciplinaire Carnot de Bourgogne [Dijon] (LICB), and Université de Bourgogne (UB)-Université de Technologie de Belfort-Montbeliard (UTBM)-Centre National de la Recherche Scientifique (CNRS)
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[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics] ,Optical fiber ,Materials science ,business.industry ,Portable water purification ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,law.invention ,010309 optics ,law ,0103 physical sciences ,Materials Chemistry ,Ceramics and Composites ,Optoelectronics ,0210 nano-technology ,business ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2020
7. Elaboration of multimaterials optical fibers combining tellurite glass and metal for electro-optical applications
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Arnaud Lemière, Sylvain Danto, Younes Messaddeq, Yannick Ledemi, Anthony Maldonado, Wagner Rafael Correr, Thierry Cardinal, Clément Strutynski, Frédéric Désévédavy, Jean-Charles Jules, Frédéric Smektala, Laboratoire Interdisciplinaire Carnot de Bourgogne [Dijon] (LICB), Université de Bourgogne (UB)-Université de Technologie de Belfort-Montbeliard (UTBM)-Centre National de la Recherche Scientifique (CNRS), Center for Optics, Photonics and Lasers (COPL), Université Laval, Quebec, QC, G1V 0A6, Canada, Institut de Chimie de la Matière Condensée de Bordeaux (ICMCB), Université de Bordeaux (UB)-Institut Polytechnique de Bordeaux-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Maurizio Ferrari, Jacob I. Mackenzie, and Stefano Taccheo
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electro-optical functionalities ,Materials science ,Optical fiber ,business.industry ,tellurite glasses ,Composite number ,Physics::Optics ,[CHIM.MATE]Chemical Sciences/Material chemistry ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Waveguide (optics) ,0104 chemical sciences ,law.invention ,Core (optical fiber) ,law ,Electrode ,Optoelectronics ,Fiber ,Photonics ,Hybrid multimaterials optical fibers ,0210 nano-technology ,business ,Refractive index - Abstract
International audience; The development and the emergence of fully integrated all-fiber optical systems is very interesting from a technical point of view in photonics. Indeed, the development of mutimaterials fibers combining both optical waveguide properties and simultaneous in-fiber electrical excitation could provide plenty of innovative signal-processing, sensing or imaging functionalities. Here, we report the engineering of a new glass/metal composite fiber. For the glass, we have chosen tellurite glasses for their excellent thermo-viscous abilities (low Tg) and linear/nonlinear optical properties. This low Tg allows to have a larger panel of potential metals to be co-drawn with. The synthesis is firstly realized by build-in-casting at room atmosphere which allows to get a large-core. Then, the rod-in-tube technique and the insertion of metallic wires allow to get a step-index fiber with a small-core (7µm) and two continuous metallic electrodes running along the fiber axis (Øelectrodes = 30µm). Thus, we obtain a tellurite-based core-clad dual-electrode composite fiber made by direct, homothetic preform-to-fiber thermal co-drawing. The rheological and optical properties of the selected glasses allow both to regulate the metallic melting flow and to manage the refractive index core/clad waveguide profile. We will discuss the engineering of these multimaterials optical fibers and their characterization: thermal and viscosity properties, linear optical properties (loss), electrical properties with a continuity of the electrodes over meters of fiber.
- Published
- 2020
8. Mid-IR supercontinuum in optical fibers drawn from low phonon energy glasses
- Author
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Arnaud Lemière, Paul Froidevaux, Anthony Maldonado, Frédéric Smektala, Frédéric Désévédavy, and Bertrand Kibler
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Optical fiber ,Materials science ,business.industry ,Infrared ,Chalcogenide ,Supercontinuum ,law.invention ,Core (optical fiber) ,chemistry.chemical_compound ,Wavelength ,Zero-dispersion wavelength ,chemistry ,law ,Optoelectronics ,business ,Spectroscopy - Abstract
Optical fibers mid-infrared (mid-IR) supercontinuum (SC) generation for sources covering the 1–20 μm range are of great interest for many applications in optics, spectroscopy, sensing for environmental monitoring or medical diagnosis and treatment. We present here our work regarding two low phonon energy glasses families, leading to highly nonlinear optical fibers for SC generation: tellurites and seleno-telluride glasses. Tellurite fibers are suitable for working in the 1-5 μm range, when seleno-telluride ones are intended to the 2-16 μm range. For tellurites, we focus on the definition of glass pairs suitable for the drawing of step index fibers with a controlled chromatic dispersion for a femto-second (fs) pumping around 2 μm. In the case of chalcogenide glasses, we focus on the Ge-Se-Te ternary system, which offers the advantage of allowing the drawing of step index or micro-structured fibers avoiding the usage of toxic arsenic. Depending on the fiber geometry the management of the chromatic dispersion is quite different. Suspended core fibers allow to shift deeply the unique zero dispersion wavelength (ZDW) towards short wavelengths for fs pumping around 2- 3 μm. For step index fibers, it is possible to design waveguides with no, one or two ZDW. Various pumping schemes are available between 3 and 9 μm, with a fs tunable source. As a result, SC generation experiments in these different fibers allows to reach wide spanning spectra, between 1 and more than 5 μm for tellurite fibers, and between 2 and more than 14 μm in the case of chalcogenides ones.
- Published
- 2020
9. Tellurite-Based Core-Clad Dual-Electrodes Composites Fibers
- Author
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Wagner Rafael Correr, Marc Dussauze, Anthony Maldonado, Frédéric Désévédavy, Yannick Ledemi, J-C Jules, Thierry Cardinal, Clément Strutynski, Younes Messaddeq, Sylvain Danto, Grégory Gadret, Olivier Bidault, Frédéric Smektala, and Arnaud Lemière
- Subjects
Core (optical fiber) ,Materials science ,Metallic electrode ,Tellurite glass ,Composite number ,Electrode ,Thermal ,Fiber ,Composite material ,Manual insertion - Abstract
Here, we propose to design a new class of glass/metal composite fibers for all-guided optical-electrical signals. The objective is to combine metal and glass materials by using additive manufacturing approach to engineer multimaterials fibers. Thus, after manual insertion of metallic electrodes into the tellurite glass preform, we can obtain the first tellurite-based core-clad dualelectrode composite fiber made by direct, homothetic preform-to-fiber thermal co-drawing.
- Published
- 2019
10. Dispersion-Engineered Step-Index Tellurite Fibers for Mid-Infrared Coherent Supercontinuum Generation from 1.5 to 4.5 μm with Sub-Nanojoule Femtosecond Pump Pulses
- Author
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Grégory Gadret, Bertrand Kibler, Arnaud Lemière, Kenshiro Nagasaka, Jean-Charles Jules, Pierre Mathey, Takenobu Suzuki, Frédéric Désévédavy, Paul Froidevaux, Frédéric Smektala, Yasutake Ohishi, Laboratoire Interdisciplinaire Carnot de Bourgogne [Dijon] (LICB), Université de Bourgogne (UB)-Université de Technologie de Belfort-Montbeliard (UTBM)-Centre National de la Recherche Scientifique (CNRS), SLCO, Laboratoire Interdisciplinaire Carnot de Bourgogne (LICB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Verres et Céramiques, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), ANR-11-LABX-01-01, Agence Nationale de la Recherche, Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), Université de Technologie de Belfort-Montbeliard (UTBM)-Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre National de la Recherche Scientifique (CNRS), and Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
optical fibers ,Optical fiber ,Materials science ,Physics::Optics ,02 engineering and technology ,lcsh:Technology ,01 natural sciences ,law.invention ,lcsh:Chemistry ,010309 optics ,symbols.namesake ,law ,0103 physical sciences ,Dispersion (optics) ,mid-infrared light sources ,Coherence (signal processing) ,General Materials Science ,Fiber ,lcsh:QH301-705.5 ,supercontinuum generation ,Instrumentation ,Nonlinear Schrödinger equation ,ComputingMilieux_MISCELLANEOUS ,Fluid Flow and Transfer Processes ,[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics] ,lcsh:T ,business.industry ,tellurite glasses ,Process Chemistry and Technology ,nonlinear optics ,General Engineering ,Nonlinear optics ,021001 nanoscience & nanotechnology ,lcsh:QC1-999 ,3. Good health ,Computer Science Applications ,Supercontinuum ,lcsh:Biology (General) ,lcsh:QD1-999 ,lcsh:TA1-2040 ,Femtosecond ,symbols ,Optoelectronics ,lcsh:Engineering (General). Civil engineering (General) ,0210 nano-technology ,business ,lcsh:Physics - Abstract
Mid-infrared supercontinuum generation from 1.5 to 4.5 µ, m with sub-nanojoule femtosecond pump pulses is demonstrated by using a short segment of dispersion-engineered step-index tellurite fiber with very low OH content. Distinct group-velocity dispersion regimes in a simple design of step-index tellurite fiber are also reported, which allows to choose the nonlinear pulse propagation regime according to the required tailoring of the supercontinuum source. Numerical simulations based on the generalized nonlinear Schrö, dinger equation are used to determine optimized fiber parameters before experimental demonstrations. We also analyse the coherence properties of the resulting supercontinuum sources.
- Published
- 2018
11. Mid-IR supercontinuum between 1 and 5 µm in step index tellurite fibres for greenhouse or pollutant gases detection (Conference Presentation)
- Author
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Frédéric Smektala, Frédéric Désévédavy, Bertrand Kibler, Paul Froidevaux, Grégory Gadret, Pierre Mathey, Arnaud Lemière, and Jean-Charles Jules
- Subjects
Materials science ,Infrared ,business.industry ,Chalcogenide ,Supercontinuum ,Core (optical fiber) ,chemistry.chemical_compound ,Wavelength ,chemistry ,Optoelectronics ,Fiber ,Spectroscopy ,business ,Refractive index - Abstract
Development of broadband supercontinuum sources has been studied since decades for its high application potential in various fields like spectroscopy, medical science and others. First experiments were made with silica but the results shown the need to find new materials for supercontinuum generation in the IR wavelength range. Two types of materials have been found interesting for supercontinuum generation: chalcogenide and tellurite glasses. These materials have a high non-linear refractive index and a good transmission in infrared which provides a high potential for applications. Bulks tellurite glasses transmit until 5µm while bulks chalcogenide glasses transmit until 12-20µm depending on their composition. We report here the synthesis of low-OH step-index tellurite fibers and their linear and non-linear characterization. The synthesis is firstly realized by build-in-casting in a glovebox which allows to get a large-core preform(∅clad/∅core 2) and a large core corresponding fiber(∅core 60µm). Then, the rod-in-tube technique allows, from the jacketing of the stretched initial preform, to get a small-core preform and subsequently a small core fiber (∅core 3.5µm). The minimum of losses of the large-core fiber is below 1dB/m, the IR transmission wavelength exceeds 4 µm on several meters of fibers and reaches more than 5 µm on small samples (several centimeters long). We have developed core-clad composition with a large refractive index difference (∆n=0.132) which provides a high confinement in our step-index fibers. We discuss the supercontinuum generation in these fibers exploiting numerical simulations based on the generalized nonlinear Schrodinger equation and then we present the supercontinuum experimental results obtained between 1 and 5µm. Most of pollutant and greenhouse gases emitted by human activity, including methane, carbon dioxide and nitrous oxide, absorbs in the mid-IR. The spectroscopic experiments realized on the gases through supercontinuum generation between 1 and 5 µm are presented.
- Published
- 2018
12. Dispersion-engineered step-index tellurite fibers for mid-infrared supercontinuum generation from 1.5 to 4.5 μm
- Author
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Frédéric Désévédavy, Arnaud Lemière, Jean-Charles Jules, Grégory Gadret, Pierre Mathey, Bertrand Kibler, Frédéric Smektala, Paul Froidevaux, Yasutake Ohishi, and Kenshiro Nagasaka
- Subjects
Materials science ,business.industry ,Mid infrared ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Supercontinuum ,010309 optics ,0103 physical sciences ,Dispersion (optics) ,Optoelectronics ,Fiber ,0210 nano-technology ,Self-phase modulation ,business - Abstract
We present the experimental development of dispersion-engineered tellurite fibers based on a simple step-index profile for mid-infrared supercontinuum generation. A supercontinuum spanning from 1.5 to 4.5 μm is obtained in a 12-cm-long fiber.
- Published
- 2018
13. Nonlinear glasses-based microstructured or step-index optical fibers: mid-IR supercontinuum generation and IR spectroscopy applications
- Author
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Arnaud Lemière, Frédéric Désévédavy, Jean-Charles Jules, J. Picot-Clémente, Paul Froidevaux, Clément Strutynski, Frédéric Smektala, Grégory Gadret, and Bertrand Kibler
- Subjects
Optical fiber ,Materials science ,Absorption spectroscopy ,business.industry ,02 engineering and technology ,Microstructured optical fiber ,Cladding (fiber optics) ,01 natural sciences ,Supercontinuum ,law.invention ,010309 optics ,020210 optoelectronics & photonics ,Optics ,Zero-dispersion wavelength ,law ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Spectroscopy ,business ,Photonic-crystal fiber - Abstract
We present an overview of the fabrication process and characterization of germanate, germanate-tellurite and tellurite microstructured fibers or step-index fibers with different index contrasts. For microstructured fibers, we exploit the generated SC for methane spectroscopy measurements in the mid-infrared by means of the supercontinuum absorption spectroscopy technique. We demonstrate also an ageing process of microstructured fibers in ambient atmosphere. For stepindex fibers, several compatible core/cladding glasses were explored for fiber manufacturing with a dehydration process, allowing the drawing of low-OH tellurite fibers. We report both numerical and experimental demonstrations supercontinuum (SC) generation in these fibers. Finally we report our latest results in the generation of SC until 5.3 μm in a step-index tellurite fiber.
- Published
- 2017
14. Mid-infrared two-octave spanning supercontinuum generation in a Ge–Se–Te glass suspended core fiber
- Author
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Franck Billard, Pierre Mathey, Christophe Aquilina, Frédéric Désévédavy, Olivier Faucher, Jean-Charles Jules, Arnaud Lemière, Frédéric Smektala, Pierre Béjot, Bertrand Kibler, Grégory Gadret, Laboratoire Interdisciplinaire Carnot de Bourgogne [Dijon] (LICB), and Université de Bourgogne (UB)-Université de Technologie de Belfort-Montbeliard (UTBM)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
[PHYS]Physics [physics] ,Optical fiber ,Materials science ,Physics and Astronomy (miscellaneous) ,business.industry ,Mid infrared ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Octave (electronics) ,01 natural sciences ,Supercontinuum ,law.invention ,010309 optics ,Core (optical fiber) ,Optics ,law ,0103 physical sciences ,Fiber ,0210 nano-technology ,business ,Instrumentation ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
- Published
- 2019
15. Mid-infrared supercontinuum generation from 2 to 14 μm in arsenic- and antimony-free chalcogenide glass fibers
- Author
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Jean-Charles Jules, Paul Froidevaux, Frédéric Désévédavy, Arnaud Lemière, Olivier Faucher, Christophe Aquilina, Pierre Béjot, Frédéric Smektala, Bertrand Kibler, Grégory Gadret, Franck Billard, Pierre Mathey, Laboratoire Interdisciplinaire Carnot de Bourgogne [Dijon] (LICB), Université de Bourgogne (UB)-Université de Technologie de Belfort-Montbeliard (UTBM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Charles Fabry de l'Institut d'Optique / Manolia, Laboratoire Charles Fabry de l'Institut d'Optique (LCFIO), Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Sud - Paris 11 (UP11), SLCO, Laboratoire Interdisciplinaire Carnot de Bourgogne (LICB), and Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS)
- Subjects
Materials science ,Optical fiber ,business.industry ,Chalcogenide ,Glass fiber ,Physics::Optics ,Chalcogenide glass ,Statistical and Nonlinear Physics ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,Supercontinuum ,law.invention ,010309 optics ,Core (optical fiber) ,chemistry.chemical_compound ,chemistry ,law ,0103 physical sciences ,Femtosecond ,Optoelectronics ,[NLIN]Nonlinear Sciences [physics] ,Photonics ,business - Abstract
International audience; We demonstrate the fabrication of arsenic-and antimony-free chalcogenide glasses compatible with glass fiber processing. Optical fibers with distinct index profiles are presented and characterized, namely, single-material fibers with or without a suspended core and standard step-index fibers with varying core diameter. In addition, we evidence their potential for nonlinear photonic devices in the mid-infrared spectral region by means of super-continuum generation experiments in the femtosecond regime. Spectral broadenings extend on several octaves in the mid-infrared from 2 to 14 μm.
- Published
- 2019
16. Met degradation: more than one stone to shoot a receptor down
- Author
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Arnaud Lemière, Ghaffar Muharram, Jonathan Lefebvre, Frédéric Ancot, Catherine Leroy, and David Tulasne
- Subjects
media_common.quotation_subject ,Leucine-Rich Repeat Proteins ,Ligands ,Biochemistry ,Receptor tyrosine kinase ,Neoplasms ,Genetics ,medicine ,Animals ,Humans ,Internalization ,Receptor ,Molecular Biology ,Caspase ,media_common ,biology ,Hepatocyte Growth Factor ,Proteins ,Proto-Oncogene Proteins c-met ,Cell biology ,Forced degradation ,biology.protein ,Hepatocyte growth factor ,Signal transduction ,Lysosomes ,Intracellular ,Signal Transduction ,Biotechnology ,medicine.drug - Abstract
The receptor tyrosine kinase Met and its high-affinity ligand, the hepatocyte growth factor/scatter factor (HGF/SF), are essential to embryonic development. Deregulation of their signaling is associated with tumorigenesis and metastasis, notably through receptor overexpression. It is thus important to understand the mechanisms controlling Met expression. The ligand-dependent internalization of Met and its subsequent degradation in the lysosomal compartment are well described. This process is known to attenuate downstream Met signaling pathways. Yet internalized Met takes part directly in intracellular signaling by chaperoning signaling factors in the course of its trafficking. Furthermore, recent studies describe various new degradation mechanisms of membrane-anchored Met, involving proteolytic cleavages or association with novel partners. Although all these degradations are ligand-independent, they share, to different extents, some common features with canonical HGF/SF-dependent degradation. Interestingly, activated Met variants display resistance to degradation, suggesting defective degradation is involved in tumorigenesis. Conversely, forced degradation of Met through reinduction of one or more degradation pathways is a promising therapeutic strategy.
- Published
- 2012
17. Fabrication and characterization of step-index tellurite fibers with varying numerical aperture for near- and mid-infrared nonlinear optics
- Author
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Paul Froidevaux, Frédéric Désévédavy, Arnaud Lemière, Clément Strutynski, Grégory Gadret, Frédéric Smektala, J. Picot-Clémente, Bertrand Kibler, and Jean-Charles Jules
- Subjects
Optical fiber ,Materials science ,Plastic-clad silica fiber ,business.industry ,Statistical and Nonlinear Physics ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Cladding (fiber optics) ,01 natural sciences ,Graded-index fiber ,Atomic and Molecular Physics, and Optics ,Supercontinuum ,law.invention ,Numerical aperture ,010309 optics ,Optics ,law ,0103 physical sciences ,0210 nano-technology ,business ,Hard-clad silica optical fiber ,Photonic-crystal fiber - Abstract
We present an overview of the fabrication process and characterization of tellurite, germanate, and germanate–tellurite step-index fibers with different index contrasts. Several compatible core/cladding glass pairs were first explored for fiber manufacturing under ambient atmosphere. The potential of the resulting waveguides for nonlinear optics is revealed by means of supercontinuum generation experiments using a near-infrared femtosecond fiber laser. Fabrication of the glass preforms was also adapted to dehydration procedures, allowing the drawing of low-OH step-index tellurite fibers. The beneficial impact of glass purification on supercontinuum generation toward the mid-infrared region is confirmed.
- Published
- 2016
18. Mid-infrared two-octave spanning supercontinuum generation in a Ge–Se–Te glass suspended core fiber.
- Author
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Arnaud Lemière, Frédéric Désévédavy, Bertrand Kibler, Pierre Mathey, Grégory Gadret, Jean-Charles Jules, Christophe Aquilina, Pierre Béjot, Franck Billard, Olivier Faucher, and Frédéric Smektala
- Published
- 2019
- Full Text
- View/download PDF
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