1,286 results on '"Arnaud, F."'
Search Results
2. Tumor and Nodal Disease Growth Rates in Patients with Oropharyngeal Squamous Cell Carcinoma
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Farber, Nicole I, Li, Yimin, Solis, Roberto N, Chen, Joy, Masheeb, Zahrah, Wilson, Machelle, Bewley, Arnaud F, Abouyared, Marianne, Rao, Shyam, Rong, Yi, and Birkeland, Andrew C
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Clinical Research ,Cancer ,Digestive Diseases ,Dental/Oral and Craniofacial Disease ,Rare Diseases ,Sexually Transmitted Infections ,oropharyngeal ,tumor growth ,squamous cell carcinoma ,Oncology and carcinogenesis - Abstract
Though specific growth rate (SGR) has potential prognostic value for oropharyngeal squamous cell carcinoma (OPSCC), there is sparse literature defining these rates. Our aims were to establish the SGRs of primary tumors (PTs) and lymph nodes (LNs) in OPSCC and to correlate SGR with oncologic outcome. A pilot study was designed with a retrospective analysis examining 54 patients from the University of California, Davis with OPSCC (diagnosed 2012-2019). Radiation oncology software and pretreatment serial CT scans were used to measure PT and LN volumes to calculate SGR and doubling time (DT). The mean PT-SGR was 1.2 ± 2.2%/day and the mean LN-SGR was 1.6 ± 1.9%/day. There was no statistically significant difference between slow-growing and fast-growing cohorts in terms of age, gender, smoking status, tumor subsite, HPV status (as determined with p16 staining), initial volume, or overall stage. SGR had no impact on 2-year overall survival, disease-free survival, or disease-specific survival. We found the average daily growth rates for OPSCC to be 1.2%/day and 1.6%/day. Our findings suggest PT- and LN-SGR are independent factors, not heavily influenced by known biomarkers and patient characteristics, without a statistical impact on prognosis. This information has value in patient counseling regarding tumor growth and in providing patients worried about fast-growing tumors the appropriate reassurance.
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- 2023
3. Bereavement Practices Among Head and Neck Cancer Surgeons
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Solis, Roberto N, Farber, Nicole I, Fairman, Nathan, Yang, Nuen T, Taylor, Sandra L, Abouyared, Marianne, Bewley, Arnaud F, Farwell, D Gregory, and Birkeland, Andrew C
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Biomedical and Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Dental/Oral and Craniofacial Disease ,Clinical Research ,Management of diseases and conditions ,7.3 Management and decision making ,Bereavement ,Family ,Head and Neck Neoplasms ,Humans ,Surgeons ,Surveys and Questionnaires ,United States ,cancer ,death ,head and neck ,survey ,Clinical Sciences ,Otorhinolaryngology ,Clinical sciences - Abstract
ObjectivesHead and neck cancer surgeons frequently interact with dying patients with advanced disease and their families, but little is known about their bereavement practices after a patient's death. The aim of this study is to elucidate the frequency of common bereavement practices, cited barriers to bereavement, and predictive physician factors that lead to an increase in bereavement practices among head and neck cancer surgeons.MethodsA 20-item survey was sent to 827 active surgeons of the American Head and Neck Society. Approval was obtained and the survey was distributed through the American Head and Neck Society. Demographics, frequency of common bereavement practices, empathy, and barriers were assessed. Multiple linear regression was performed to determine physician factors associated with more frequent bereavement follow-up.ResultsThere were 156 respondents (18.9% response rate). Overall, surgeons were more likely to usually/always call (48.5%) or send a letter (42.4%) compared with other practices such as attending funerals (0%), offering family meetings (18.6%), or referring family members to counseling (7.7%). Many barriers were cited as being at least somewhat important: being unaware about a patient's death (67.3%) was the most cited, whereas 51.3% cited a lack of mentorship/training in this area. Scoring higher on empathy questions (P ≤ .001) was associated with more frequent surgeon bereavement follow-up with the family of deceased patients.ConclusionThere is substantial practice variation among surgeons suggesting a lack of consensus on their roles in bereavement follow-up. Having higher empathy was predictive of higher engagement.Level of evidenceNA Laryngoscope, 132:1971-1975, 2022.
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- 2022
4. Intraoperative delineation of p16+ oropharyngeal carcinoma of unknown primary origin with fluorescence lifetime imaging: Preliminary report
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Weyers, Brent W, Birkeland, Andrew C, Marsden, Mark A, Tam, Athena, Bec, Julien, Frusciante, Roberto P, Gui, Dorina, Bewley, Arnaud F, Abouyared, Marianne, Marcu, Laura, and Farwell, Donald Gregory
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Cancer ,Dental/Oral and Craniofacial Disease ,Machine Learning and Artificial Intelligence ,Digestive Diseases ,Rare Diseases ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Carcinoma ,Squamous Cell ,Fluorescence ,Head and Neck Neoplasms ,Humans ,Neoplasms ,Unknown Primary ,Oropharyngeal Neoplasms ,cancer delineation ,endogenous autofluorescence ,fluorescence lifetime imaging ,intraoperative surgical guidance ,machine learning in oncology applications ,occult primary tumor ,oropharyngeal cancer of unknown primary origin ,p16+squamous cell carcinoma ,transoral robotic surgery ,p16+ squamous cell carcinoma ,Dentistry ,Otorhinolaryngology ,Clinical sciences - Abstract
BackgroundThis study evaluated whether fluorescence lifetime imaging (FLIm), coupled with standard diagnostic workups, could enhance primary lesion detection in patients with p16+ head and neck squamous cell carcinoma of the unknown primary (HNSCCUP).MethodsFLIm was integrated into transoral robotic surgery to acquire optical data on six HNSCCUP patients' oropharyngeal tissues. An additional 55-patient FLIm dataset, comprising conventional primary tumors, trained a machine learning classifier; the output predicted the presence and location of HNSCCUP for the six patients. Validation was performed using histopathology.ResultsAmong the six HNSCCUP patients, p16+ occult primary was surgically identified in three patients, whereas three patients ultimately had no identifiable primary site in the oropharynx. FLIm correctly detected HNSCCUP in all three patients (ROC-AUC: 0.90 ± 0.06), and correctly predicted benign oropharyngeal tissue for the remaining three patients. The mean sensitivity was 95% ± 3.5%, and specificity 89% ± 12.7%.ConclusionsFLIm may be a useful diagnostic adjunct for detecting HNSCCUP.
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- 2022
5. Early Detection of Lymph Node Metastasis Using Primary Head and Neck Cancer Computed Tomography and Fluorescence Lifetime Imaging
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Nimu Yuan, Mohamed A. Hassan, Katjana Ehrlich, Brent W. Weyers, Garrick Biddle, Vladimir Ivanovic, Osama A. A. Raslan, Dorina Gui, Marianne Abouyared, Arnaud F. Bewley, Andrew C. Birkeland, D. Gregory Farwell, Laura Marcu, and Jinyi Qi
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radiomics ,machine learning ,head and neck cancer ,lymph node metastasis ,CT ,fluorescence lifetime imaging ,Medicine (General) ,R5-920 - Abstract
Objectives: Early detection and accurate diagnosis of lymph node metastasis (LNM) in head and neck cancer (HNC) are crucial for enhancing patient prognosis and survival rates. Current imaging methods have limitations, necessitating new evaluation of new diagnostic techniques. This study investigates the potential of combining pre-operative CT and intra-operative fluorescence lifetime imaging (FLIm) to enhance LNM prediction in HNC using primary tumor signatures. Methods: CT and FLIm data were collected from 46 HNC patients. A total of 42 FLIm features and 924 CT radiomic features were extracted from the primary tumor site and fused. A support vector machine (SVM) model with a radial basis function kernel was trained to predict LNM. Hyperparameter tuning was conducted using 10-fold nested cross-validation. Prediction performance was evaluated using balanced accuracy (bACC) and the area under the ROC curve (AUC). Results: The model, leveraging combined CT and FLIm features, demonstrated improved testing accuracy (bACC: 0.71, AUC: 0.79) over the CT-only (bACC: 0.58, AUC: 0.67) and FLIm-only (bACC: 0.61, AUC: 0.72) models. Feature selection identified that a subset of 10 FLIm and 10 CT features provided optimal predictive capability. Feature contribution analysis identified high-pass and low-pass wavelet-filtered CT images as well as Laguerre coefficients from FLIm as key predictors. Conclusions: Combining CT and FLIm of the primary tumor improves the prediction of HNC LNM compared to either modality alone. Significance: This study underscores the potential of combining pre-operative radiomics with intra-operative FLIm for more accurate LNM prediction in HNC, offering promise to enhance patient outcomes.
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- 2024
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6. Polyamine Metabolites as Biomarkers in Head and Neck Cancer Biofluids
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DeFelice, Brian C, Fiehn, Oliver, Belafsky, Peter, Ditterich, Constanze, Moore, Michael, Abouyared, Marianne, Beliveau, Angela M, Farwell, D Gregory, Bewley, Arnaud F, Clayton, Shannon M, Archard, Joehleen A, Pavlic, Jordan, Rao, Shyam, Kuhn, Maggie, Deng, Peter, Halmai, Julian, Fink, Kyle D, Birkeland, Andrew C, and Anderson, Johnathon D
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Medical Biochemistry and Metabolomics ,Biomedical and Clinical Sciences ,Cancer ,Dental/Oral and Craniofacial Disease ,Prevention ,Rare Diseases ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Good Health and Well Being ,head and neck cancer ,biomarkers ,metabolomics ,polyamines ,saliva ,urine ,Clinical sciences - Abstract
Background: Novel, non-invasive diagnostic biomarkers that facilitate early intervention in head and neck cancer are urgently needed. Polyamine metabolites have been observed to be elevated in numerous cancer types and correlated with poor prognosis. The aim of this study was to assess the concentration of polyamines in the saliva and urine from head and neck cancer (HNC) patients, compared to healthy controls. Methods: Targeted metabolomic analysis was performed on saliva and urine from 39 HNC patient samples and compared to 89 healthy controls using a quantitative, targeted liquid chromatography mass spectrometry approach. Results: The metabolites N1-acetylspermine (ASP), N8-acetylspermidine (ASD) and N1,N12-diacetylspermine (DAS) were detected at significantly different concentrations in the urine of HNC patients as compared to healthy controls. Only ASP was detected at elevated levels in HNC saliva as compared to healthy controls. Conclusion: These data suggest that assessment of polyamine-based metabolite biomarkers within the saliva and urine warrants further investigation as a potential diagnostic in HNC patients.
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- 2022
7. Head and Neck Cutaneous Soft-Tissue Sarcoma Demonstrate Sex and Racial/Ethnic Disparities in Incidence and Socioeconomic Disparities in Survival
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Jawad, Muhammad Umar, Zeitlinger, Lauren N, Bewley, Arnaud F, O’Donnell, Edmond F, Traven, Sophia A, Carr-Ascher, Janai R, Monjazeb, Arta M, Canter, Robert J, Thorpe, Steven W, and Randall, R Lor
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Clinical Research ,Rare Diseases ,Cancer ,Dental/Oral and Craniofacial Disease ,cutaneous soft tissue sarcoma ,disparities ,Clinical Sciences - Abstract
BackgroundCutaneous soft-tissue sarcoma (CSTS) of the head and neck are rare and are known to have aggressive clinical course. The current study utilizes a population-based registry in the U.S. to characterize these malignancies and explore disparities.MethodsNational Cancer Institute's (NCI) Surveillance, Epidemiology and End Result (SEER) database from 2000 to 2018 was queried to report incidence and survival data in 4253 cases in the U.S.ResultsMales were 5.37 times more likely and Non-Hispanic-White people (NHW) were 4.62 times more likely than females and Non-Hispanic-Black people (NHB) to develop CSTS of the head and neck. The overall incidence was 0.27 per 100,000 persons in 2018, with a significant increase since 2000. Advanced age and stage, histologic group other than 'fibromatous sarcoma' and lower SES groups were independent factors for worse overall survival.ConclusionsCSTS of the head and neck demonstrate sex and racial/ethnic disparities in incidence and socioeconomic disparities in overall survival.Level of evidenceII.
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- 2022
8. FLIm-Based in Vivo Classification of Residual Cancer in the Surgical Cavity During Transoral Robotic Surgery.
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Mohamed A. Hassan, Brent W. Weyers, Julien Bec, Jinyi Qi, Dorina Gui, Arnaud F. Bewley, Marianne Abouyared, D. Gregory Farwell, Andrew C. Birkeland, and Laura Marcu
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- 2023
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9. The Impact of COVID‐19 on Head and Neck Cancer Treatment: Before and During the Pandemic
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Solis, Roberto N, Mehrzad, Mehrnaz, Faiq, Samya, Frusciante, Roberto P, Sekhon, Harveen K, Abouyared, Marianne, Bewley, Arnaud F, Farwell, D Gregory, and Birkeland, Andrew C
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Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Prevention ,Cancer ,Rare Diseases ,Dental/Oral and Craniofacial Disease ,6.4 Surgery ,Evaluation of treatments and therapeutic interventions ,Good Health and Well Being ,COVID-19 ,head and neck cancer ,pandemic ,head and neck cancer care ,delays in care - Abstract
ObjectivesTo describe the impact that the coronavirus disease 2019 (COVID-19) pandemic had on the presentation of patients with head and neck cancer in a single tertiary care center.Study designRetrospective cohort study.SettingAcademic institution.MethodsWe performed a retrospective review of patients with newly diagnosed head and neck squamous cell carcinoma (HNSCC) who presented as new patients between September 10, 2019, and September 11, 2020. Patients presenting during the 6 months leading up to the announcement of the pandemic (pre-COVID-19 period) on March 11, 2020, were compared to those presenting during the first 6 months of the pandemic (COVID-19 period). Demographics, time to diagnosis and treatment, and tumor characteristics were analyzed.ResultsThere were a total of 137 patients analyzed with newly diagnosed malignancies. There were 22% fewer patients evaluated during the COVID-19 timeframe. The groups were similar in demographics, duration of symptoms, time to diagnosis, time to surgery, extent of surgery, and adjuvant therapy. There was a larger proportion of tumors classified as T3/T4 (61.7%) in the COVID-19 period vs the pre-COVID-19 period (40.3%) (P = .024), as well as a larger median tumor size during the COVID-19 period (P = .0002). There were no differences between nodal disease burden (P = .48) and distant metastases (P = .42).ConclusionDespite similar characteristics, time to diagnosis, and surgery, our findings suggest that there was an increase in primary tumor burden in patients with HNSCC during the early COVID-19 pandemic.
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- 2021
10. 28nm Fully-Depleted SOI Technology: Cryogenic Control Electronics for Quantum Computing
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Bohuslavskyi, H., Barraud, S., Cassé, M., Barral, V., Bertrand, B., Hutin, L., Arnaud, F., Galy, P., Sanquer, M., De Franceschi, S., and Vinet, M.
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Physics - Applied Physics ,Condensed Matter - Mesoscale and Nanoscale Physics ,Quantum Physics - Abstract
This paper reports the first cryogenic characterization of 28nm Fully-Depleted-SOI CMOS technology. A comprehensive study of digital/analog performances and body-biasing from room to the liquid helium temperature is presented. Despite a cryogenic operation, effectiveness of body-biasing remains unchanged and provides an excellent $V_{TH}$ controllability. Low-temperature operation enables higher drive current and a largely reduced subthreshold swing (down to 7mV/dec). FDSOI can provide a valuable approach to cryogenic low-power electronics. Applications such as classical control hardware for quantum processors are envisioned.
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- 2019
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11. Intraoperative Margin Assessment in Oral and Oropharyngeal Cancer Using Label-Free Fluorescence Lifetime Imaging and Machine Learning
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Marsden, Mark, Weyers, Brent W, Bec, Julien, Sun, Tianchen, Gandour-Edwards, Regina F, Birkeland, Andrew C, Abouyared, Marianne, Bewley, Arnaud F, Farwell, D Gregory, and Marcu, Laura
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Engineering ,Biomedical Engineering ,Information and Computing Sciences ,Electronics ,Sensors and Digital Hardware ,Computer Vision and Multimedia Computation ,Minority Health ,Dental/Oral and Craniofacial Disease ,Machine Learning and Artificial Intelligence ,Bioengineering ,Health Disparities ,Digestive Diseases ,Rare Diseases ,Cancer ,Humans ,Machine Learning ,Margins of Excision ,Optical Imaging ,Oropharyngeal Neoplasms ,Robotic Surgical Procedures ,Surgery ,Imaging ,Robots ,Probes ,Machine learning ,Feature extraction ,medical robotics ,surgical guidance ,navigation ,Artificial Intelligence and Image Processing ,Electrical and Electronic Engineering ,Biomedical engineering ,Electronics ,sensors and digital hardware ,Computer vision and multimedia computation - Abstract
ObjectiveTo demonstrate the diagnostic ability of label-free, point-scanning, fiber-based Fluorescence Lifetime Imaging (FLIm) as a means of intraoperative guidance during oral and oropharyngeal cancer removal surgery.MethodsFLIm point-measurements acquired from 53 patients (n = 67893 pre-resection in vivo, n = 89695 post-resection ex vivo) undergoing oral or oropharyngeal cancer removal surgery were used for analysis. Discrimination of healthy tissue and cancer was investigated using various FLIm-derived parameter sets and classifiers (Support Vector Machine, Random Forests, CNN). Classifier output for the acquired set of point-measurements was visualized through an interpolation-based approach to generate a probabilistic heatmap of cancer within the surgical field. Classifier output for dysplasia at the resection margins was also investigated.ResultsStatistically significant change (P 0.01) between healthy and cancer was observed in vivo for the acquired FLIm signal parameters (e.g., average lifetime) linked with metabolic activity. Superior classification was achieved at the tissue region level using the Random Forests method (ROC-AUC: 0.88). Classifier output for dysplasia (% probability of cancer) was observed to lie between that of cancer and healthy tissue, highlighting FLIm's ability to distinguish various conditions.ConclusionThe developed approach demonstrates the potential of FLIm for fast, reliable intraoperative margin assessment without the need for contrast agents.SignificanceFiber-based FLIm has the potential to be used as a diagnostic tool during cancer resection surgery, including Transoral Robotic Surgery (TORS), helping ensure complete resections and improve the survival rate of oral and oropharyngeal cancer patients.
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- 2021
12. TLP/VFTLP investigation on eNVM 1T1R PCM in FD-SOI UTBB CMOS technology at room temperature
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Galy, Ph., Jacquier, B., Sandrini, J., and Arnaud, F.
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- 2023
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13. Anatomy-Specific Classification Model Using Label-Free FLIm to Aid Intraoperative Surgical Guidance of Head and Neck Cancer.
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Mohamed Abul Hassan, Brent W. Weyers, Julien Bec, Farzad Fereidouni, Jinyi Qi, Dorina Gui, Arnaud F. Bewley, Marianne Abouyared, D. Gregory Farwell, Andrew C. Birkeland, and Laura Marcu
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- 2023
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14. Cryogenic characterization of 28nm FD-SOI ring oscillators with energy efficiency optimization
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Bohuslavskyi, H., Barraud, S., Barral, V., Cassé, M., Guevel, L. Le, Hutin, L., Bertrand, B., Crippa, A., Jehl, X., Pillonnet, G., Jansen, A. G. M., Arnaud, F., Galy, P., Maurand, R., De Franceschi, S., Sanquer, M., and Vinet, M.
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Physics - Applied Physics ,Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
Extensive electrical characterization of ring oscillators (ROs) made in high-$\kappa$ metal gate 28nm Fully-Depleted Silicon-on- Insulator (FD-SOI) technology is presented for a set of temperatures between 296 and 4.3K. First, delay per stage ($\tau_P$), static current ($I_{STAT}$), and dynamic current ($I_{DYN}$) are analyzed for the case of the increase of threshold voltage ($V_{TH}$) observed at low temperature. Then, the same analysis is performed by compensating $V_{TH}$ to a constant, temperature independent value through forward body-biasing (FBB). Energy efficiency optimization is proposed for different supply voltages ($V_{DD}$) in order to find an optimal operating point combining both high RO frequencies and low power dissipation. We show that the Energy-Delay product ($EDP$) can be significantly reduced at low temperature by applying a forward body bias voltage ($V_{FBB}$). We demonstrate that outstanding performance of RO in terms of speed ($\tau_P$=37ps) and static power (7nA/stage) can be achieved at 4.3K with $V_{DD}$ reduced down to 0.325V.
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- 2019
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15. Cryogenic Subthreshold Swing Saturation in FD-SOI MOSFETs described with Band Broadening
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Bohuslavskyi, H., Jansen, A. G. M., Barraud, S., Barral, V., Cassé, M., Guevel, L. Le, Jehl, X., Hutin, L., Bertrand, B., Billiot, G., Pillonnet, G., Arnaud, F., Galy, P., De Franceschi, S., Vinet, M., and Sanquer, M.
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Condensed Matter - Mesoscale and Nanoscale Physics - Abstract
In the standard MOSFET description of the drain current $I_{D}$ as a function of applied gate voltage $V_{GS}$, the subthreshold swing $SS(T)\equiv dV_{GS}/d\log I_{D}$ has a fundamental lower limit as a function of temperature $T$ given by $SS(T) = \ln10~k_BT/e$. However, recent low-temperature studies of different advanced CMOS technologies have reported $SS$(4K or lower) values that are at least an order of magnitude larger. Here, we present and analyze the saturation of $SS(T)$ in 28nm fully-depleted silicon-on-insulator (FD-SOI) devices for both n- and p-type MOSFETs of different gate oxide thicknesses and gate lengths down to 4K. Until now, the increase of interface-trap density close to the band edge as temperature decreases has been put forward to understand the saturation. Here, an original explanation of the phenomenon is presented by considering a disorder-induced tail in the density of states at the conduction (valence) band edge for the calculation of the MOS channel transport by applying Fermi-Dirac statistics. This results in a subthreshold $I_{D}\sim e^{eV_{GS}/k_BT_0}$ for $T_0=35$K with saturation value $SS(T
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- 2019
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16. Advanced head and neck surgery training during the COVID-19 pandemic.
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Givi, Babak, Moore, Michael G, Bewley, Arnaud F, Coffey, Charles S, Cohen, Marc A, Hessel, Amy C, Jalisi, Scharukh, Kang, Steven, Newman, Jason G, Puscas, Liana, Shindo, Maisie, Shuman, Andrew, Thakkar, Punam, Weed, Donald T, and Chalian, Ara
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Humans ,Pneumonia ,Viral ,Coronavirus Infections ,Head and Neck Neoplasms ,Risk Assessment ,Otolaryngology ,Communicable Disease Control ,Fellowships and Scholarships ,Curriculum ,Education ,Medical ,Graduate ,Clinical Competence ,Occupational Health ,Employment ,United States ,Female ,Male ,Pandemics ,Patient Safety ,Surveys and Questionnaires ,COVID-19 ,education ,head and neck surgery ,pandemic ,surgical education ,Dental/Oral and Craniofacial Disease ,Quality Education ,Clinical Sciences ,Dentistry ,Otorhinolaryngology - Abstract
BackgroundThe COVID-19 pandemic has significantly impacted medical training. Here we assess its effect on head and neck surgical education.MethodsSurveys were sent to current accredited program directors and trainees to assess the impact of COVID-19 on the fellow's experience and employment search. Current fellows' operative logs were compared with those of the 2018 to 2019 graduates.ResultsDespite reduction in operative volume, 82% of current American Head and Neck Society fellows have reached the number of major surgical operations to support certification. When surveyed, 86% of program directors deemed their fellow ready to enter practice. The majority of fellows felt prepared to practice ablative (96%), and microvascular surgery (73%), and 57% have secured employment to follow graduation. Five (10%) had a pending job position put on hold due to the pandemic.ConclusionsDespite the impact of the COVID-19 pandemic, current accredited trainees remain well-positioned to obtain proficiency and enter the work-force.
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- 2020
17. Immunoregulatory Potential of Exosomes Derived from Cancer Stem Cells
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Clayton, Shannon M, Archard, Joehleen A, Wagner, Joseph, Farwell, D Gregory, Bewley, Arnaud F, Beliveau, Angela, Birkeland, Andrew, Rao, Shyam, Abouyared, Marianne, Belafsky, Peter C, and Anderson, Johnathon D
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Biological Sciences ,Stem Cell Research - Nonembryonic - Human ,Cancer ,Dental/Oral and Craniofacial Disease ,Stem Cell Research ,Stem Cell Research - Nonembryonic - Non-Human ,Rare Diseases ,Clinical Research ,Aetiology ,2.1 Biological and endogenous factors ,Carcinoma ,Squamous Cell ,Cell Differentiation ,Cell Self Renewal ,Exosomes ,Head and Neck Neoplasms ,Humans ,Neoplasm Recurrence ,Local ,Neoplastic Stem Cells ,Signal Transduction ,Tumor Microenvironment ,cancer stem cells ,exosomes ,regulatory T lymphocytes ,m2 macrophages ,head and neck cancer ,secretory proteins ,Technology ,Medical and Health Sciences ,Developmental Biology ,Immunology ,Biological sciences - Abstract
Head and neck squamous cell carcinomas (HNSCCs) are malignancies that originate in the mucosal lining of the upper aerodigestive tract. Despite advances in therapeutic interventions, survival rates among HNSCC patients have remained static for years. Cancer stem cells (CSCs) are tumor-initiating cells that are highly resistant to treatment, and are hypothesized to contribute to a significant fraction of tumor recurrences. Consequently, further investigations of how CSCs mediate recurrence may provide insights into novel druggable targets. A key element of recurrence involves the tumor's ability to evade immunosurveillance. Recent published reports suggest that CSCs possess immunosuppressive properties, however, the underlying mechanism have yet to be fully elucidated. To date, most groups have focused on the role of CSC-derived secretory proteins, such as cytokines and growth factors. Here, we review the established immunoregulatory role of exosomes derived from mixed tumor cell populations, and propose further study of CSC-derived exosomes may be warranted. Such studies may yield novel insights into new druggable targets, or lay the foundation for future exosome-based diagnostics.
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- 2020
18. Fluorescence lifetime imaging for intraoperative cancer delineation in transoral robotic surgery.
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Weyers, Brent W, Marsden, Mark, Sun, Tianchen, Bec, Julien, Bewley, Arnaud F, Gandour-Edwards, Regina F, Moore, Michael G, Farwell, D Gregory, and Marcu, Laura
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autofluorescence ,coregistration techniques ,fluorescence lifetime imaging ,head and neck cancer ,intraoperative surgical guidance ,robotic surgery ,surgical visualization ,Cancer ,Biomedical Imaging ,Bioengineering ,Clinical Research - Abstract
This study evaluates the potential for fluorescence lifetime imaging (FLIm) to enhance intraoperative decisionmaking during robotic-assisted surgery of oropharyngeal cancer. Using a custom built FLIm instrument integrated with the da Vinci robotic surgical platform, we first demonstrate that cancer in epithelial tissue diagnosed by histopathology can be differentiated from surrounding healthy epithelial tissue imaged in vivo prior to cancer resection and ex vivo on the excised specimen. Second, we study the fluorescence properties of tissue imaged in vivo at surgical resection margins (tumor bed). Fluorescence lifetimes and spectral intensity ratios were calculated for three spectral channels, producing a set of six FLIm parameters. Current results from 10 patients undergoing TORS procedures demonstrate that healthy epithelium can be resolved from cancer (P < .001) for at least one FLIm parameter. We also showed that a multiparameter linear discriminant analysis approach provides superior discrimination to individual FLIm parameters for tissue imaged both in vivo and ex vivo. Overall, this study highlights the potential for FLIm to be developed into a diagnostic tool for clinical cancer applications of the oropharynx. This technique could help to circumvent the issues posed by the lack of tactile feedback associated with robotic surgical platforms to better enable cancer delineation.
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- 2019
19. HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection.
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Timbang, Mary Roz, Sim, Michael W, Bewley, Arnaud F, Farwell, D Gregory, Mantravadi, Avinash, and Moore, Michael G
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Humans ,Papillomaviridae ,Papillomavirus Infections ,Carcinoma ,Squamous Cell ,Head and Neck Neoplasms ,Oropharyngeal Neoplasms ,Incidence ,Risk Factors ,Cost of Illness ,United States ,Papillomavirus Vaccines ,Early Detection of Cancer ,HPV ,Oropharyngeal cancer ,detection ,prevention ,screening ,vaccination ,Cancer ,Prevention ,Clinical Trials and Supportive Activities ,Cervical Cancer ,Digestive Diseases ,Clinical Research ,Rare Diseases ,Infectious Diseases ,Sexually Transmitted Infections ,Dental/Oral and Craniofacial Disease ,Infection ,Good Health and Well Being ,Immunology ,Medical Microbiology ,Pharmacology and Pharmaceutical Sciences ,Virology - Abstract
The incidence of oropharyngeal cancer (OPC) related to infection with human papillomavirus (HPV) is rising, making it now the most common HPV-related malignancy in the United States. These tumors present differently than traditional mucosal head and neck cancers, and those affected often lack classic risk factors such as tobacco and alcohol use. Currently, there are no approved approaches for prevention and early detection of disease, thus leading many patients to present with advanced cancers requiring intense surgical or nonsurgical therapies resulting in significant side effects and cost to the health-care system. In this review, we outline the evolving epidemiology of HPV-related OPC. We also summarize the available evidence corresponding to HPV-related OPC prevention, including efficacy and safety of the HPV vaccine in preventing oral HPV infections. Finally, we describe emerging techniques for identifying and screening those who may be at high risk for developing these tumors.
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- 2019
20. Essential Cases in Head and Neck Oncology
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Michael G. Moore, Arnaud F. Bewley, Babak Givi, Michael G. Moore, Arnaud F. Bewley, Babak Givi and Michael G. Moore, Arnaud F. Bewley, Babak Givi, Michael G. Moore, Arnaud F. Bewley, Babak Givi
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- 2022
21. Impact of warmer climate periods on flood hazard in the European Alps
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Wilhelm, B., Rapuc, W., Amann, B., Anselmetti, F. S., Arnaud, F., Blanchet, J., Brauer, A., Czymzik, M., Giguet-Covex, C., Gilli, A., Glur, L., Grosjean, M., Irmler, R., Nicolle, M., Sabatier, P., Swierczynski, T., and Wirth, S. B.
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- 2022
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22. Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats
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Arandel, Ludovic, Matloka, Magdalena, Klein, Arnaud F., Rau, Frédérique, Sureau, Alain, Ney, Michel, Cordier, Aurélien, Kondili, Maria, Polay-Espinoza, Micaela, Naouar, Naira, Ferry, Arnaud, Lemaitre, Mégane, Begard, Séverine, Colin, Morvane, Lamarre, Chloé, Tran, Hélène, Buée, Luc, Marie, Joëlle, Sergeant, Nicolas, and Furling, Denis
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- 2022
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23. The clinical behavior and genomic features of the so-called adenoid cystic carcinomas of the solid variant with basaloid features
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Schwartz, Christopher J., Brogi, Edi, Marra, Antonio, Da Cruz Paula, Arnaud F, Nanjangud, Gouri J., da Silva, Edaise M., Patil, Sujata, Shah, Shreena, Ventura, Katia, Razavi, Pedram, Norton, Larry, D’alfonso, Timothy, Weigelt, Britta, Pareja, Fresia, Reis-Filho, Jorge S., and Wen, Hannah Y.
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- 2022
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24. Adaptive neuro-synergetic control technique for SEPIC converter in PV systems
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Nguimfack-Ndongmo, Jean de Dieu, Kenné, Godpromesse, Kuate-Fochie, René, Tchouani Njomo, Arnaud F., and Mbaka Nfah, Eustace
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- 2022
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25. Role of Prosthetics and Osseointegration in Lateral Craniofacial Reconstruction
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Kinzinger, Michael, Bewley, Arnaud F., Wang, Steven J, editor, and Fung, Kevin, editor
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- 2021
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26. Diverse alterations associated with resistance to KRAS(G12C) inhibition
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Zhao, Yulei, Murciano-Goroff, Yonina R., Xue, Jenny Y., Ang, Agnes, Lucas, Jessica, Mai, Trang T., Da Cruz Paula, Arnaud F., Saiki, Anne Y., Mohn, Deanna, Achanta, Pragathi, Sisk, Ann E., Arora, Kanika S., Roy, Rohan S., Kim, Dongsung, Li, Chuanchuan, Lim, Lee P., and Li, Mark
- Subjects
Oncology, Experimental ,Drug resistance -- Research ,Chemical inhibitors -- Dosage and administration ,Lung cancer -- Drug therapy ,Cancer -- Research ,Environmental issues ,Science and technology ,Zoology and wildlife conservation - Abstract
Inactive state-selective KRAS(G12C) inhibitors.sup.1-8 demonstrate a 30-40% response rate and result in approximately 6-month median progression-free survival in patients with lung cancer.sup.9. The genetic basis for resistance to these first-in-class mutant GTPase inhibitors remains under investigation. Here we evaluated matched pre-treatment and post-treatment specimens from 43 patients treated with the KRAS(G12C) inhibitor sotorasib. Multiple treatment-emergent alterations were observed across 27 patients, including alterations in KRAS, NRAS, BRAF, EGFR, FGFR2, MYC and other genes. In preclinical patient-derived xenograft and cell line models, resistance to KRAS(G12C) inhibition was associated with low allele frequency hotspot mutations in KRAS(G12V or G13D), NRAS(Q61K or G13R), MRAS(Q71R) and/or BRAF(G596R), mirroring observations in patients. Single-cell sequencing in an isogenic lineage identified secondary RAS and/or BRAF mutations in the same cells as KRAS(G12C), where they bypassed inhibition without affecting target inactivation. Genetic or pharmacological targeting of ERK signalling intermediates enhanced the antiproliferative effect of G12C inhibitor treatment in models with acquired RAS or BRAF mutations. Our study thus suggests a heterogenous pattern of resistance with multiple subclonal events emerging during G12C inhibitor treatment. A subset of patients in our cohort acquired oncogenic KRAS, NRAS or BRAF mutations, and resistance in this setting may be delayed by co-targeting of ERK signalling intermediates. These findings merit broader evaluation in prospective clinical trials. Multiple treatment-emergent alterations appear in patients with advanced-stage cancer who were treated with a KRAS inhibitor., Author(s): Yulei Zhao [sup.1] , Yonina R. Murciano-Goroff [sup.2] , Jenny Y. Xue [sup.1] [sup.3] , Agnes Ang [sup.4] , Jessica Lucas [sup.1] , Trang T. Mai [sup.1] , Arnaud [...]
- Published
- 2021
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- View/download PDF
27. Tracing Natural Organic Matter at the Scale of Drainage Basins
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Pépin-Donat, B., Poulenard, J., Blondel, T., Lombard, C., Protière, M., Dudal, Y., Perrette, Y., Fanget, B., Miège, C., Delannoy, J.-J., Dorioz, J. -M., Emblanch, C., Arnaud, F., Giguet-Covex, C., and Bertrand, Patrick
- Published
- 2020
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28. Crystallization behavior of N -doped Ge-rich GST thin films and nanostructures: An in-situ synchrotron X-ray diffraction study
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Thomas, O., Mocuta, C., Putero, M., Richard, M.-I., Boivin, P., and Arnaud, F.
- Published
- 2021
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29. Tumor and Nodal Disease Growth Rates in Patients with Oropharyngeal Squamous Cell Carcinoma
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Nicole I. Farber, Yimin Li, Roberto N. Solis, Joy Chen, Zahrah Masheeb, Machelle Wilson, Arnaud F. Bewley, Marianne Abouyared, Shyam Rao, Yi Rong, and Andrew C. Birkeland
- Subjects
oropharyngeal ,tumor growth ,squamous cell carcinoma ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Though specific growth rate (SGR) has potential prognostic value for oropharyngeal squamous cell carcinoma (OPSCC), there is sparse literature defining these rates. Our aims were to establish the SGRs of primary tumors (PTs) and lymph nodes (LNs) in OPSCC and to correlate SGR with oncologic outcome. A pilot study was designed with a retrospective analysis examining 54 patients from the University of California, Davis with OPSCC (diagnosed 2012–2019). Radiation oncology software and pretreatment serial CT scans were used to measure PT and LN volumes to calculate SGR and doubling time (DT). The mean PT-SGR was 1.2 ± 2.2%/day and the mean LN-SGR was 1.6 ± 1.9%/day. There was no statistically significant difference between slow-growing and fast-growing cohorts in terms of age, gender, smoking status, tumor subsite, HPV status (as determined with p16 staining), initial volume, or overall stage. SGR had no impact on 2-year overall survival, disease-free survival, or disease-specific survival. We found the average daily growth rates for OPSCC to be 1.2%/day and 1.6%/day. Our findings suggest PT- and LN-SGR are independent factors, not heavily influenced by known biomarkers and patient characteristics, without a statistical impact on prognosis. This information has value in patient counseling regarding tumor growth and in providing patients worried about fast-growing tumors the appropriate reassurance.
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- 2023
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30. A 1600 year-long sedimentary record of tsunamis and hurricanes in the Lesser Antilles (Scrub Island, Anguilla)
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Biguenet, M., Sabatier, P., Chaumillon, E., Chagué, C., Arnaud, F., Jorissen, F., Coulombier, T., Geba, E., Cordrie, L., Vacher, P., Develle, A.L., Chalmin, E., Soufi, F., and Feuillet, N.
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- 2021
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31. Radiothérapie et toxicité médullaire : actualités et perspectives
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Peyraga, G., Ducassou, A., Arnaud, F.-X., Lizée, T., Pouédras, J., and Moyal, É.
- Published
- 2021
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32. Intraoperative Margin Assessment in Oral and Oropharyngeal Cancer Using Label-Free Fluorescence Lifetime Imaging and Machine Learning.
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Mark Marsden, Brent W. Weyers, Julien Bec, Tianchen Sun, Regina F. Gandour-Edwards, Andrew C. Birkeland, Marianne Abouyared, Arnaud F. Bewley, D. Gregory Farwell, and Laura Marcu
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- 2021
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33. Oropharyngeal reconstruction after transoral robotic surgery
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Silverman, Dustin A., Birkeland, Andrew C., and Bewley, Arnaud F.
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- 2022
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34. Characterization and clinical validation of patient-specific three-dimensional printed tissue-equivalent bolus for radiotherapy of head and neck malignancies involving skin
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Dyer, Brandon A., Campos, David D., Hernandez, Daniel D., Wright, Cari L., Perks, Julian R., Lucero, Steven A., Bewley, Arnaud F., Yamamoto, Tokihiro, Zhu, Xiandong, and Rao, Shyam S.
- Published
- 2020
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35. CT predictors of sub-centimeter occult lymph node metastases in oral cavity squamous cell carcinoma: A case-control study
- Author
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Morisada, Megan V, primary, Bewley, Arnaud F, additional, Broadhead, Kenneth, additional, Assadsangabi, Reza, additional, Paydar, Alireza, additional, Birkeland, Andrew C, additional, Abouyared, Marianne, additional, Qi, Lihong, additional, and Ivanovic, Vladimir, additional
- Published
- 2023
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- View/download PDF
36. 3D sequential integration with Si CMOS stacked on 28nm industrial FDSOI with Cu-ULK iBEOL featuring RO and HDR pixel
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Mota-Frutuoso, T., primary, Lapras, V., additional, Brunet, L., additional, Basset, L., additional, Lugo, J., additional, Fenouillet-Beranger, C., additional, Vinet, M., additional, Lattard, D., additional, Boulard, F., additional, Exbraya, Y., additional, Boutry, D., additional, Billoint, O., additional, Bosch, D., additional, Maneglia, Y., additional, Peizerat, A., additional, Dumas, S., additional, Sicard, G., additional, Kerdiles, S., additional, Kanyandekwe, J., additional, Sideris, P., additional, Mazzocchi, V., additional, Sarrazin, A., additional, Loup, V., additional, Mauguen, G., additional, Morales, C., additional, Alba, P. Acosta, additional, Balan, V., additional, Perrot, C., additional, Sturm, J., additional, Euvrard, C., additional, Aussenac, F., additional, Janaud, A., additional, Chapon, J-D., additional, Guillermet, M., additional, Guglieri, S., additional, Bailly, F., additional, Toresani, P., additional, Fournel, F., additional, Mouhdach, M., additional, Berthoud, A., additional, Chapelon, L-L., additional, Ribotta, M., additional, Ponthenier, F., additional, Magalhaes, A., additional, Maitrejean, S., additional, Moulin, C., additional, Michailos, J., additional, Arnaud, F., additional, Cathelin, A., additional, Arcamone, J., additional, Andrieu, F., additional, Garros, X., additional, Gaillard, F., additional, and Batude., P., additional
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- 2023
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37. Chondroblastoma of the Clivus: Case Report and Review
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Liu, Jonathan, Ahmadpour, Arjang, Bewley, Arnaud F, Lechpammer, Mirna, Bobinski, Matthew, and Shahlaie, Kiarash
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Dental/Oral and Craniofacial Disease ,Pediatric ,Cancer ,Pediatric Research Initiative ,Rare Diseases ,chondroblastoma ,clivus ,endoscopic endonasal approach ,clival tumor - Abstract
Background and Importance Chondroblastoma is a benign primary bone tumor that typically develops in the epiphyses of long bones. Chondroblastoma of the craniofacial skeleton is extremely rare, with most cases occurring in the squamosal portion of the temporal bone. In this report, we describe the first case of chondroblastoma of the clivus presenting with cranial neuropathy that was treated with endoscopic endonasal resection. We review the literature on craniofacial chondroblastomas with particular emphasis on extratemporal lesions. Case Presentation A 27-year-old woman presented with severe headache, left facial dysesthesias, and diplopia. Physical examination revealed hypesthesia in the left maxillary nerve dermatome, and complete left abducens nerve palsy. Imaging demonstrated an expansile intraosseous mass originating in the upper clivus with extension superiorly into the sella turcica and laterally to involve the medial wall of the left cavernous sinus. The tumor was completely resected via an endoscopic endonasal approach, with postoperative improvement in lateral gaze palsy. Histopathology was consistent with chondroblastoma. Conclusion Chondroblastoma is a rare tumor of the craniofacial skeleton that should be included in the differential diagnosis of an osteolytic lesion of the clivus. Complete surgical resection remains the mainstay of treatment.
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- 2015
38. The Impact of COVID-19 on Head and Neck Cancer Treatment: Before and During the Pandemic
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Roberto N. Solis MD, Mehrnaz Mehrzad, Samya Faiq, Roberto P. Frusciante, Harveen K. Sekhon, Marianne Abouyared MD, Arnaud F. Bewley MD, D. Gregory Farwell MD, and Andrew C. Birkeland MD
- Subjects
Otorhinolaryngology ,RF1-547 ,Surgery ,RD1-811 - Abstract
Objectives To describe the impact that the coronavirus disease 2019 (COVID-19) pandemic had on the presentation of patients with head and neck cancer in a single tertiary care center. Study Design Retrospective cohort study. Setting Academic institution. Methods We performed a retrospective review of patients with newly diagnosed head and neck squamous cell carcinoma (HNSCC) who presented as new patients between September 10, 2019, and September 11, 2020. Patients presenting during the 6 months leading up to the announcement of the pandemic (pre–COVID-19 period) on March 11, 2020, were compared to those presenting during the first 6 months of the pandemic (COVID-19 period). Demographics, time to diagnosis and treatment, and tumor characteristics were analyzed. Results There were a total of 137 patients analyzed with newly diagnosed malignancies. There were 22% fewer patients evaluated during the COVID-19 timeframe. The groups were similar in demographics, duration of symptoms, time to diagnosis, time to surgery, extent of surgery, and adjuvant therapy. There was a larger proportion of tumors classified as T3/T4 (61.7%) in the COVID-19 period vs the pre–COVID-19 period (40.3%) ( P = .024), as well as a larger median tumor size during the COVID-19 period ( P = .0002). There were no differences between nodal disease burden ( P = .48) and distant metastases ( P = .42). Conclusion Despite similar characteristics, time to diagnosis, and surgery, our findings suggest that there was an increase in primary tumor burden in patients with HNSCC during the early COVID-19 pandemic.
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- 2021
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39. Peptide-conjugated oligonucleotides evoke long-lasting myotonic dystrophy correction in patient-derived cells and mice
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Klein, Arnaud F., Varela, Miguel A., Arandel, Ludovic, Holland, Ashling, Naouar, Naira, Arzumanov, Andrey, Seoane, David, Revillod, Lucile, Bassez, Guillaume, Ferry, Arnaud, Jauvin, Dominic, Gourdon, Genevieve, Puymirat, Jack, Gait, Michael J., Furling, Denis, and Wood, Matthew J.A.
- Subjects
Myotonic dystrophy -- Genetic aspects -- Health aspects ,Skeletal muscle -- Health aspects ,Peptides -- Health aspects ,RNA -- Health aspects ,Arginine ,Protein kinases ,Phenotypes ,Health care industry - Abstract
Antisense oligonucleotides (ASOs) targeting pathologic RNAs have shown promising therapeutic corrections for many genetic diseases including myotonic dystrophy (DM1). Thus, ASO strategies for DM1 can abolish the toxic RNA gain-of-function mechanism caused by nucleus-retained mutant DMPK (DM1 protein kinase) transcripts containing CUG expansions (CUGexps). However, systemic use of ASOs for this muscular disease remains challenging due to poor drug distribution to skeletal muscle. To overcome this limitation, we test an arginine-rich Pip6a cell-penetrating peptide and show that Pip6aconjugated morpholino phosphorodiamidate oligomer (PMO) dramatically enhanced ASO delivery into striated muscles of DM1 mice following systemic administration in comparison with unconjugated PMO and other ASO strategies. Thus, low-dose treatment with Pip6a-PMO-CAG targeting pathologic expansions is sufficient to reverse both splicing defects and myotonia in DM1 mice and normalizes the overall disease transcriptome. Moreover, treated DM1 patient-derived muscle cells showed that Pip6a-PMO-CAG specifically targets mutant CUGexp-DMPK transcripts to abrogate the detrimental sequestration of MBNL1 splicing factor by nuclear RNA foci and consequently MBNL1 functional loss, responsible for splicing defects and muscle dysfunction. Our results demonstrate that Pip6a-PMO-CAG induces long- lasting correction with high efficacy of DM1-associated phenotypes at both molecular and functional levels, and strongly support the use of advanced peptide conjugates for systemic corrective therapy in DM1., Introduction Myotonic dystrophy (DM1), one of the most common muscular dystrophies in adults (1), is an RNA-dominant disorder caused by the expression of expanded microsatellite repeats located in the 3' [...]
- Published
- 2019
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40. National Trends and Factors Associated with Hospital Costs Following Thyroid Surgery.
- Author
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Biron, Vincent L, Bang, Heejung, Farwell, D Gregory, and Bewley, Arnaud F
- Subjects
Humans ,Thyroid Diseases ,Postoperative Complications ,Hospitalization ,Length of Stay ,Thyroidectomy ,Lymph Node Excision ,Severity of Illness Index ,Linear Models ,Retrospective Studies ,Cohort Studies ,Cross-Sectional Studies ,Comorbidity ,Middle Aged ,Hospitals ,Rural ,Hospital Costs ,Diagnosis-Related Groups ,United States ,Female ,Male ,Patient Safety ,Clinical Research ,Genetics ,Clinical Sciences ,Endocrinology & Metabolism - Abstract
BackgroundMedical costs in the United States have been increasing disproportionally to gross domestic product, raising concerns about the sustainability of U.S. healthcare expenditures. Care of patients with thyroid disease has been identified as an area of medicine where cost increases have been pronounced.ObjectivesThe goals of this study were to identify potential drivers of the cost of hospitalization following thyroid surgery, and to understand which of these factors may be contributing to observed increases in cost from 2003 to 2011.MethodsA retrospective cross-sectional analysis of discharge data from the Nationwide Inpatient Sample (NIS) database for all admissions following thyroid lobectomy or total thyroidectomy in the years 2003, 2007, and 2011 was performed. Multiple regression analysis via a weighted generalized linear model was used to identify factors that were independently associated with high cost of hospitalization. Trend as well as subgroup analyses were then performed to identify which of these factors could be contributing to increasing costs.ResultsThere were 47,854 hospital admissions following total thyroidectomy or thyroid lobectomy identified in the years 2003, 2007, and 2011. The aggregate national cost of hospitalization increased from $198 million in 2003 to $373 million in 2011 in inflation-adjusted 2011 dollars. The weighted mean cost of hospitalization following thyroid surgery increased from $6154 to $8982 from 2003 to 2011 in inflation-adjusted 2011 dollars. Higher comorbidity score, total thyroidectomy, lymphadenectomy, western region, rural region, and certain postoperative complications were the factors most highly associated with increased hospital costs. Of these, an increasing proportion of patients with higher severity of illness score and an increasing proportion of patients undergoing total thyroidectomy and lymphadenectomy were implicated as the most likely contributors to the cost increases. The rate of total thyroidectomy and lymphadenectomy was found to be increasing for patients with both benign and malignant thyroid disease.ConclusionsAccording to the NIS data set, costs associated with hospitalization after thyroid surgery increased markedly from 2003 to 2011. This increase could be in part due to a growing proportion of sicker patients undergoing more extensive surgery, but a number of confounders in this study limit the conclusions. Further analysis of factors that could be associated with the rising costs of inpatient thyroid surgery should be undertaken.
- Published
- 2015
41. Head and Neck Cutaneous Soft-Tissue Sarcoma Demonstrate Sex and Racial/Ethnic Disparities in Incidence and Socioeconomic Disparities in Survival
- Author
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Muhammad Umar Jawad, Lauren N. Zeitlinger, Arnaud F. Bewley, Edmond F. O’Donnell, Sophia A. Traven, Janai R. Carr-Ascher, Arta M. Monjazeb, Robert J. Canter, Steven W. Thorpe, and R. Lor Randall
- Subjects
cutaneous soft tissue sarcoma ,disparities ,Medicine - Abstract
Background: Cutaneous soft-tissue sarcoma (CSTS) of the head and neck are rare and are known to have aggressive clinical course. The current study utilizes a population-based registry in the U.S. to characterize these malignancies and explore disparities. Methods: National Cancer Institute’s (NCI) Surveillance, Epidemiology and End Result (SEER) database from 2000 to 2018 was queried to report incidence and survival data in 4253 cases in the U.S. Results: Males were 5.37 times more likely and Non-Hispanic-White people (NHW) were 4.62 times more likely than females and Non-Hispanic-Black people (NHB) to develop CSTS of the head and neck. The overall incidence was 0.27 per 100,000 persons in 2018, with a significant increase since 2000. Advanced age and stage, histologic group other than ‘fibromatous sarcoma’ and lower SES groups were independent factors for worse overall survival. Conclusions: CSTS of the head and neck demonstrate sex and racial/ethnic disparities in incidence and socioeconomic disparities in overall survival. Level of evidence: II.
- Published
- 2022
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42. CT predictors of sub-centimeter occult lymph node metastases in oral cavity squamous cell carcinoma: A case-control study.
- Author
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Morisada, Megan V, Bewley, Arnaud F, Broadhead, Kenneth, Assadsangabi, Reza, Paydar, Alireza, Birkeland, Andrew C, Abouyared, Marianne, Qi, Lihong, and Ivanovic, Vladimir
- Abstract
Background: For patients with oral cavity squamous cell carcinoma (OCSCC) without evidence of nodal metastasis (cN0) on pre-operative evaluation, there are no clear guidelines who should undergo elective neck dissection (END) versus clinical surveillance. Objective: To identify CT imaging characteristics of sub-centimeter lymph nodes that would help predict the likelihood of nodal metastases on pathology. Methods: Retrospective review of cN0 OCSCC patients at a tertiary academic medical center was performed. Inclusion criteria included elective neck dissection, pre-operative CT imaging and presence of metastatic disease within lymph nodes. Control group consisted of patients without nodal metastases on pathology. CT features that were evaluated included asymmetric size, disrupted fatty hilum, asymmetric number, presence of cortical nodule, cortical nodule size, and round/oval shape. We evaluated the associations between CT LN features and the presence of metastases using multi-level mixed-effects logistic regression models. Model evaluation was performed using 5-fold cross-validation. The positive predictive value (PPV) and negative predictive value (NPV) were calculated. Results: 26 patients in each study and control groups were included. Three-level mixed-effects logistic regression models indicated round/oval shape (OR = 1.39, p =.01), asymmetric number (OR = 7.20, p =.005), and disrupted fatty hilum (OR = 3.31, p =.04) to be independently predictive in a 3-variable model with sensitivity = 38.0%, specificity = 92.0%, and PPV = 93.8%. Conclusions: In cN0 OCSCC patients undergoing END, round/oval shape, asymmetric number, and disrupted fatty hilum of lymph nodes on pre-operative CT imaging are novel and highly predictive of occult nodal disease. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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43. Comparing Field, Probabilistic, and 2D Numerical Approaches to Assess Gravel Mobility in a Gravel‐Bed River
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Arnaud, F., primary, Paquier, A., additional, Vázquez‐Tarrío, D., additional, Camenen, B., additional, Le Coz, J., additional, Michel, K., additional, Naudet, G., additional, Pella, H., additional, and Piégay, H., additional
- Published
- 2023
- Full Text
- View/download PDF
44. HPV-related oropharyngeal cancer: a review on burden of the disease and opportunities for prevention and early detection
- Author
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Mary Roz Timbang, Michael W. Sim, Arnaud F. Bewley, D. Gregory Farwell, Avinash Mantravadi, and Michael G. Moore
- Subjects
oropharyngeal cancer ,hpv ,vaccination ,detection ,screening ,prevention ,Immunologic diseases. Allergy ,RC581-607 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
The incidence of oropharyngeal cancer (OPC) related to infection with human papillomavirus (HPV) is rising, making it now the most common HPV-related malignancy in the United States. These tumors present differently than traditional mucosal head and neck cancers, and those affected often lack classic risk factors such as tobacco and alcohol use. Currently, there are no approved approaches for prevention and early detection of disease, thus leading many patients to present with advanced cancers requiring intense surgical or nonsurgical therapies resulting in significant side effects and cost to the health-care system. In this review, we outline the evolving epidemiology of HPV-related OPC. We also summarize the available evidence corresponding to HPV-related OPC prevention, including efficacy and safety of the HPV vaccine in preventing oral HPV infections. Finally, we describe emerging techniques for identifying and screening those who may be at high risk for developing these tumors.
- Published
- 2019
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45. Role of Prosthetics and Osseointegration in Lateral Craniofacial Reconstruction
- Author
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Kinzinger, Michael, primary and Bewley, Arnaud F., additional
- Published
- 2020
- Full Text
- View/download PDF
46. Laryngeal Transplantation
- Author
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Bewley, Arnaud F., primary and Farwell, D. Gregory, additional
- Published
- 2020
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- View/download PDF
47. Microsurgical techniques in maxillofacial surgery
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Bewley, Arnaud F., primary and Arzi, Boaz, additional
- Published
- 2020
- Full Text
- View/download PDF
48. Head and Neck Cancer and the Elderly Patient
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Cervenka, Brian P., Rao, Shyam, and Bewley, Arnaud F.
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- 2018
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49. Prise en charge en imagerie du traumatisé grave (hors radiologie interventionnelle)
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Scemama, U., Arnaud, F., Soussan, J., Léone, M., and Chaumoitre, K.
- Published
- 2018
- Full Text
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50. Nerve grafts in head and neck reconstruction
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Hoshal, Steven G., Solis, Roberto N., and Bewley, Arnaud F.
- Published
- 2020
- Full Text
- View/download PDF
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