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389 results on '"Arnaldi, G."'

8. Towards the tailoring of glucocorticoid replacement in adrenal insufficiency: the Italian Society of Endocrinology Expert Opinion

Author

Isidori, A. M., Arnaldi, G., Boscaro, M., Falorni, A., Giordano, C., Giordano, R., Pivonello, R., Pozza, C., Sbardella, E., Simeoli, C., Scaroni, C., and Lenzi, A.

Abstract

Context: Glucocorticoid (GC) replacement therapy in patients with adrenal insufficiency (AI) is life saving. After over 50 years of conventional GC treatment, novel formulations are now entering routine clinical practice. Methods: Given the spectrum of medications currently available and new insights into the understanding of AI, the authors reviewed relevant medical literature with emphasis on original studies, prospective observational data and randomized controlled trials performed in the past 35 years. The Expert Opinion of a panel of selected endocrinologists was sought to answer specific clinical questions. The objective was to provide an evidence-supported guide, for the use of GC in various settings from university hospitals to outpatient clinics, that offers specific advice tailored to the individual patient. Results: The Panel reviewed available GC replacement therapies, comprising short-acting, intermediate and long-acting oral formulations, subcutaneous formulations and the novel modified-release hydrocortisone. Advantages and disadvantages of these formulations were reviewed. Conclusions: In the Panel’s opinion, achieving the optimal GC timing and dosing is needed to improve the outcome of AI. No-single formulation offers the best option for every patients. Recent data suggest that more emphasis should be given to the timing of intake. Tailoring of GS should be attempted in all patients—by experts—on a case-by-case basis. The Panel identified specific subgroups of AI patients that could be help by this process. Long-term studies are needed to confirm the short-term benefits associated with the modified-release GCs. The impact of GC tailoring has yet to be proven in terms of hospitalization rate, morbidity and mortality.

Published
2024
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9. Approach to hyponatremia according to the clinical setting: Consensus statement from the Italian Society of Endocrinology (SIE), Italian Society of Nephrology (SIN), and Italian Association of Medical Oncology (AIOM)

Author

Sbardella, E., Isidori, A. M., Arnaldi, G., Arosio, M., Barone, C., Benso, A., Berardi, R., Capasso, G., Caprio, M., Ceccato, F., Corona, G., Della Casa, S., De Nicola, L., Faustini-Fustini, M., Fiaccadori, E., Gesualdo, L., Gori, S., Lania, A., Mantovani, G., Menè, P., Parenti, G., Pinto, C., Pivonello, R., Razzore, P., Regolisti, G., Scaroni, C., Trepiccione, F., Lenzi, A., Peri, A., and On behalf of the: Fluid and Electrolyte Disorders Club of the Italian Society of Endocrinology; Italian Society of Nephrology; and Italian Association of Medical Oncology

Published
2017
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11. Pegvisomant in acromegaly: an update

Author

Giustina, A., Arnaldi, G., Bogazzi, F., Cannavò, S., Colao, A., De Marinis, L., De Menis, E., Degli Uberti, E., Giorgino, F., Grottoli, S., Lania, A. G., Maffei, P., Pivonello, R., and Ghigo, E.

Published
2017
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21. Conventional and Nuclear Medicine Imaging in Ectopic Cushingʼs Syndrome: A Systematic Review

Author

Isidori, Andrea M., Sbardella, Emilia, Zatelli, Maria Chiara, Boschetti, Mara, Vitale, Giovanni, Colao, Annamaria, Pivonello, Rosario, Albiger, N., Ambrogio, A., Arnaldi, G., Arvat, E., Berardelli, R., Boscaro, M., Boschetti, M., Cannavò, S., Cavagnini, F., Colao, A., Corsello, S. M., Cozzolino, A., De Leo, M., Di Somma, C., Esposito, K., Ferone, D., Foresta, C., Gatto, F., Giordano, C., Giugliano, D., Graziadio, C., Isidori, A. M., Loli, P., Manetti, L., Mannelli, M., Marzullo, P., Mantero, F., Minuto, F., Paragliola, R. M., Giraldi, F. Pecori, Pivonello, R., Reimondo, G., Scaroni, C., Scillitani, A., Simeoli, C., Stigliano, A., Terzolo, M., Tortora, F., Trementino, L., Vitale, G., and Zatelli, M. C.

Published
2015

22. ENSAT registry-based randomized clinical trials for adrenocortical carcinoma

Author

Crona, J. Baudin, E. Terzolo, M. Chrisoulidou, A. Angelousi, A. Ronchi, C.L. Oliveira, C.L. Nieveen van Dijkum, E.J.M. Ceccato, F. Borson-Chazot, F. Reimondo, G. Tiberi, G.A.M. Ettaieb, H. Kiriakopoulos, A. Letizia, C. Kastelan, D. Osher, E. Yiannakopoulou, E. Arnaldi, G. Assié, G. Paiva, I. Bourdeau, I. Newell-Price, J. Nowak, K.M. Tous Romero, M. de Martino, M.C. Bugalho, M.J. Sherlock, M. Vantyghem, M.-C. Dennedy, M.C. Loli, P. Rodien, P. Feelders, R. de Krijger, R. van Slycke, S. Aylwin, S. Morelli, V. Vroonen, L. Shafigullina, Z. Bancos, I. Trofimiuk-Müldner, M. Quinkler, M. Luconi, M. Kroiss, M. Naruse, M. Igaz, P. Mihai, R. della Casa, S. Berruti, A. Fassnacht, M. Beuschlein, F.

Abstract

Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been introduced in clinical research, so allowing for significant cost reduction, but without compromising scientific benefit. Herein, we describe how the European Network for the Study of Adrenal Tumours (ENSAT) could transform its current registry into one fit for a clinical trial infrastructure. The rationale to perform randomized registry-based trials in ACC is outlined including an analysis of relevant limitations and challenges. We summarize a survey on this concept among ENSAT members who expressed a strong interest in the concept and rated its scientific potential as high. Legal aspects, including ethical approval of registry-based randomization were identified as potential obstacles. Finally, we describe three potential randomized registry-based clinical trials in an adjuvant setting and for advanced disease with a high potential to be executed within the framework of an advanced ENSAT registry. Thus we, therefore, provide the basis for future registry-based trials for ACC patients. This could ultimately provide proof-of-principle of how to perform more effective randomized trials for an orphan disease. © 2021 BioScientifica Ltd.. All rights reserved.

Published
2021

23. ENSAT registry-based randomized clinical trials for adrenocortical carcinoma

Author

Crona, J, Baudin, E, Terzolo, M, Chrisoulidou, A, Angelousi, A, Ronchi, CL, Oliveira, CL, van Dijkum, E, Ceccato, F, Borson-Chazot, F, Reimondo, G, Tiberi, GAM, Ettaieb, H, Kiriakopoulos, A, Letizia, C, Kastelan, D, Osher, E, Yiannakopoulou, E, Arnaldi, G, Assie, G, Paiva, I, Bourdeau, I, Newell-Price, J, Nowak, KM, Romero, MT, de Martino, MC, Bugalho, MJ, Sherlock, M, Vantyghem, MC, Dennedy, MC, Loli, P, Rodien, P, Feelders, R.A., de Krijger, R, Van Slycke, S, Aylwin, S, Morelli, V, Vroonen, L, Shafigullina, Z, Bancos, I, Trofimiuk-Muldner, M, Quinkler, M, Luconi, M, Kroiss, M, Naruse, M, Igaz, P, Mihai, R, Della Casa, S, Berruti, A, Fassnacht, M, Beuschlein, F, Crona, J, Baudin, E, Terzolo, M, Chrisoulidou, A, Angelousi, A, Ronchi, CL, Oliveira, CL, van Dijkum, E, Ceccato, F, Borson-Chazot, F, Reimondo, G, Tiberi, GAM, Ettaieb, H, Kiriakopoulos, A, Letizia, C, Kastelan, D, Osher, E, Yiannakopoulou, E, Arnaldi, G, Assie, G, Paiva, I, Bourdeau, I, Newell-Price, J, Nowak, KM, Romero, MT, de Martino, MC, Bugalho, MJ, Sherlock, M, Vantyghem, MC, Dennedy, MC, Loli, P, Rodien, P, Feelders, R.A., de Krijger, R, Van Slycke, S, Aylwin, S, Morelli, V, Vroonen, L, Shafigullina, Z, Bancos, I, Trofimiuk-Muldner, M, Quinkler, M, Luconi, M, Kroiss, M, Naruse, M, Igaz, P, Mihai, R, Della Casa, S, Berruti, A, Fassnacht, M, and Beuschlein, F

Abstract

Adrenocortical carcinoma (ACC) is an orphan disease lacking effective systemic treatment options. The low incidence of the disease and high cost of clinical trials are major obstacles in the search for improved treatment strategies. As a novel approach, registry-based clinical trials have been introduced in clinical research, so allowing for significant cost reduction, but without compromising scientific benefit. Herein, we describe how the European Network for the Study of Adrenal Tumours (ENSAT) could transform its current registry into one fit for a clinical trial infrastructure. The rationale to perform randomized registry-based trials in ACC is outlined including an analysis of relevant limitations and challenges. We summarize a survey on this concept among ENSAT members who expressed a strong interest in the concept and rated its scientific potential as high. Legal aspects, including ethical approval of registry-based randomization were identified as potential obstacles. Finally, we describe three potential randomized registry-based clinical trials in an adjuvant setting and for advanced disease with a high potential to be executed within the framework of an advanced ENSAT registry. Thus we, therefore, provide the basis for future registry-based trials for ACC patients. This could ultimately provide proof-of-principle of how to perform more effective randomized trials for an orphan disease.

Published
2021

24. Natural history of gastro-entero-pancreatic and thoracic neuroendocrine tumors. Data from a large prospective and retrospective Italian Epidemiological study: THE NET MANAGEMENT STUDY

Author

Faggiano, A., Ferolla, P., Grimaldi, F., Campana, D., Manzoni, M., Davì, M. V., Bianchi, A., Valcavi, R., Papini, E., Giuffrida, D., Ferone, D., Fanciulli, G., Arnaldi, G., Franchi, G. M., Francia, G., Fasola, G., Crinò, L., Pontecorvi, A., Tomassetti, P., and Colao, A.

Published
2012
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30. Pegvisomant in acromegaly: Why, when, how

Author

Colao, A., Arnaldi, G., Beck-Peccoz, P., Cannavò, S., Cozzi, R., degli Uberti, E., De Marinis, L., De Menis, E., Ferone, D., Gasco, V., Giustina, A., Grottoli, S., Lombardi, G., Maffei, P., Martino, E., Minuto, F., Pivonello, R., and Ghigo, E.

Published
2007
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36. Correction to: Pegvisomant in acromegaly: an update (Journal of Endocrinological Investigation, (2017), 40, 6, (577-589), 10.1007/s40618-017-0614-1)

Author

Giustina, A., Arnaldi, G., Bogazzi, F., Cannavò, S., Colao, A., De Marinis, L., De Menis, E., Degli Uberti, E., Giorgino, F., Grottoli, S., Lania, A. G., Maffei, P., Pivonello, R., Ghigo, E., Giustina, A., Arnaldi, G., Bogazzi, F., Cannavò, S., Colao, A., De Marinis, L., De Menis, E., Degli Uberti, E., Giorgino, F., Grottoli, S., Lania, A. G., Maffei, P., Pivonello, R., and Ghigo, E.

Subjects
Endocrinology, Endocrinology, Diabetes and Metabolism
Published
2018

41. Diagnosis and Complications of Cushing’s Syndrome: A Consensus Statement

Author

Arnaldi, G, Angeli, A, Atkinson, A B., Bertagna, X, Cavagnini, F, Chrousos, G P., Fava, G A., Findling, J W., Gaillard, R C., Grossman, A B., Kola, B, Lacroix, A, Mancini, T, Mantero, F, Newell-Price, J, Nieman, L K., Sonino, N, Vance, M L., Giustina, A, and Boscaro, M

Published
2003

43. Approach to hyponatremia according to the clinical setting: Consensus statement from the Italian Society of Endocrinology (SIE), Italian Society of Nephrology (SIN), and Italian Association of Medical Oncology (AIOM)

Author

Sbardella, E, Isidori, A, Arnaldi, G, Arosio, M, Barone, C, Benso, A, Berardi, R, Capasso, G, Caprio, M, Ceccato, F, Corona, G, Della Casa, Silvia, De Nicola, L, Faustini-Fustini, M, Fiaccadori, E, Gesualdo, L, Gori, S, Lania, A, Mantovani, G, Mene, P, Parenti, G, Pinto, C, Pivonello, R, Razzore, P, Regolisti, G, Scaroni, C, Trepiccione, F, Lenzi, A, Peri, A, Della Casa, S (ORCID:0000-0003-4796-9217), Sbardella, E, Isidori, A, Arnaldi, G, Arosio, M, Barone, C, Benso, A, Berardi, R, Capasso, G, Caprio, M, Ceccato, F, Corona, G, Della Casa, Silvia, De Nicola, L, Faustini-Fustini, M, Fiaccadori, E, Gesualdo, L, Gori, S, Lania, A, Mantovani, G, Mene, P, Parenti, G, Pinto, C, Pivonello, R, Razzore, P, Regolisti, G, Scaroni, C, Trepiccione, F, Lenzi, A, Peri, A, and Della Casa, S (ORCID:0000-0003-4796-9217)

Abstract

N/A

Published
2018

44. The role of inferior petrosal sinus sampling in ACTH-dependent Cushing's syndrome: review and joint opinion statement by members of the Italian Society for Endocrinology, Italian Society for Neurosurgery, and Italian Society for Neuroradiology

Author

Pecori Giraldi, Francesca, Cavallo, Luigi Maria, Tortora, Fabio, Pivonello, Rosario, Colao, Annamaria, Cappabianca, Paolo, Mantero, Franco, Albiger, N, Alviggi, C, Ambrogio, Ag, Arnaldi, G, Arvat, E, Baldelli, R, Boscaro, M, Campo, M, Cannavo', Salvatore, Cavagnini, F, Chiodini, I, Corsello, Sm, Cozzolino, A, Di Leo, M, De Martino, Mc, Di Somma, C, Esposito, K, Ferone, D, Gatto, F, Giordano, R, Giugliano, D, Graziadio, C, Grimaldi, F, Iacuaniello, D, Isidori, A, Karamouzis, I, Lenzi, A, Loli, P, Mannelli, M, Marzullo, P, Morelli, V, Paragliola, Rm, Parenti, G, Pivolenno, C, Reimondo, G, Scaroni, C, Alfredo, S, Simeoli, C, Stigliano, A, Talco, M, Terzolo, M, Trementino, L, Urbani, C, Vitale, G, Zatelli, Mc, Giraldi, F, Cavallo, Lm, Tortora, F, Pivonello, Rosario, Colao, Annamaria, Cappabianca, Paolo, Mantero, F, Albiger, N, Alviggi, Carlo, Ambrogio, Ag, Arnaldi, G, Arvat, E, Baldelli, R, Boscaro, M, Campo, M, Cannavò, S, Cavagnini, F, Chiodini, I, Corsello, Sm, Cozzolino, A, Di Leo, M, De Martino, M, Di Somma, C, Esposito, K, Ferone, D, Gatto, F, Giordano, R, Giugliano, D, Graziadio, C, Grimaldi, F, Iacuaniello, D, Isidori, A, Karamouzis, I, Lenzi, A, Loli, P, Mannelli, M, Marzullo, P, Morelli, V, Paragliola, Rm, Parenti, G, Pivolenno, C, Reimondo, G, Scaroni, C, Alfredo, S, Simeoli, C, Stigliano, A, Talco, M, Terzolo, M, Trementino, L, Urbani, C, Vitale, G, Zatelli, Mc, Pecori Giraldi, F, Tortora, Fabio, Pivonello, R, Colao, A, Cappabianca, P, Giugliano, Dario, and Esposito, Katherine

Subjects
ACTH = adrenocorticotropic hormone, diagnosis, ACTH = adrenocorticotropic hormone, or corticotropin, CRH = corticotropin-releasing hormone, Cushing's disease, Cushing's syndrome, IPSS = inferior petrosal sinus sampling, NIH = National Institutes of Health, diagnosis, inferior petrosal sinus sampling, pituitary adenoma, pituitary imaging, pituitary surgery, adrenocorticotropic hormone, Cushing syndrome, endocrinology, humans, Italy, neuroradiography, neurosurgery, petrosal sinus sampling, societies, medical, Cushing's syndrome, pituitary adenoma, Petrosal Sinus Sampling, urologic and male genital diseases, or corticotropin, ACTH = adrenocorticotropic hormone, or corticotropin, medical, Endocrinology, Cushing Syndrome, Societies, Medical, Neuroradiology, General Medicine, inferior petrosal sinus sampling, Inferior petrosal sinus sampling, CRH = corticotropin-releasing hormone, Cushing's disease, IPSS = inferior petrosal sinus sampling, NIH = National Institutes of Health, pituitary imaging, pituitary surgery, Italy, Neuroradiography, Diagnosis, Pituitary adenoma, Pituitary imaging, Pituitary surgery, Adrenocorticotropic Hormone, Humans, Neurosurgery, Surgery, Neurology (clinical), hormones, hormone substitutes, and hormone antagonists, medicine.medical_specialty, education, Context (language use), Neuroradiologist, Adrenocorticotropic hormone, societies, Internal medicine, medicine, business.industry, Settore MED/13 - ENDOCRINOLOGIA, medicine.disease, business
Abstract

In the management of adrenocorticotropic hormone (ACTH)–dependent Cushing's syndrome, inferior petrosal sinus sampling (IPSS) provides information for the endocrinologist, the neurosurgeon, and the neuroradiologist. To the endocrinologist who performs the etiological diagnosis, results of IPSS confirm or exclude the diagnosis of Cushing's disease with 80%–100% sensitivity and over 95% specificity. Baseline central-peripheral gradients have suboptimal accuracy, and stimulation with corticotropin-releasing hormone (CRH), possibly desmopressin, has to be performed. The rationale for the use of IPSS in this context depends on other diagnostic means, taking availability of CRH and reliability of dynamic testing and pituitary imaging into account. As regards the other specialists, the neuroradiologist may collate results of IPSS with findings at imaging, while IPSS may prove useful to the neurosurgeon to chart a surgical course. The present review illustrates the current standpoint of these 3 specialists on the role of IPSS.

Published
2015

50. Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH)

Author

Bonomi, Marco, primary, Vezzoli, Valeria, additional, Krausz, Csilla, additional, Guizzardi, Fabiana, additional, Vezzani, Silvia, additional, Simoni, Manuela, additional, Bassi, Ivan, additional, Duminuco, Paolo, additional, Di Iorgi, Natascia, additional, Giavoli, Claudia, additional, Pizzocaro, Alessandro, additional, Russo, Gianni, additional, Moro, Mirella, additional, Fatti, Letizia, additional, Ferlin, Alberto, additional, Mazzanti, Laura, additional, Zatelli, Maria Chiara, additional, Cannavò, Salvo, additional, Isidori, Andrea M, additional, Pincelli, Angela Ida, additional, Prodam, Flavia, additional, Mancini, Antonio, additional, Limone, Paolo, additional, Tanda, Maria Laura, additional, Gaudino, Rossella, additional, Salerno, Mariacarolina, additional, Francesca, Pregnolato, additional, Maghnie, Mohamad, additional, Maggi, Mario, additional, Persani, Luca, additional, _, _, additional, Aimaretti, G, additional, Altobelli, M, additional, Ambrosio, M R, additional, Andrioli, M, additional, Angeletti, G, additional, Arecco, F, additional, Arnaldi, G, additional, Arosio, M, additional, Balsamo, A, additional, Baldassarri, M, additional, Bartalena, L, additional, Bazzoni, N, additional, Beccaria, L, additional, Beck-Peccoz, P, additional, Bellastella, G, additional, Bellizzi, M, additional, Benedicenti, F, additional, Bernasconi, S, additional, Bizzarri, C, additional, Bona, G, additional, Bonadonna, S, additional, Borretta, G, additional, Boschetti, M, additional, Brunani, A, additional, Brunelli, V, additional, Buzi, F, additional, Cacciatore, C, additional, Cangiano, B, additional, Cappa, M, additional, Casalone, R, additional, Cassio, A, additional, Cavarzere, P, additional, Cherubini, V, additional, Ciampani, T, additional, Cicognani, D, additional, Cignarelli, A, additional, Cisternino, M, additional, Colombo, P, additional, Corbetta, S, additional, Corciulo, N, additional, Corona, G, additional, Cozzi, R, additional, Crivellaro, C, additional, Dalle Mule, I, additional, Danesi, L, additional, D’Elia, A V, additional, degli Uberti, E, additional, De Leo, S, additional, Della Valle, E, additional, De Marchi, M, additional, Di Iorgi, N, additional, Di Mambro, A, additional, Fabbri, A, additional, Foresta, C, additional, Forti, G, additional, Franceschi, A R, additional, Garolla, A, additional, Ghezzi, M, additional, Giacomozzi, C, additional, Giusti, M, additional, Grosso, E, additional, Guabello, G, additional, Guarneri, M P, additional, Grugni, G, additional, Isidori, A M, additional, Lanfranco, F, additional, Lania, A, additional, Lanzi, R, additional, Larizza, L, additional, Lenzi, A, additional, Loche, S, additional, Loli, P, additional, Lombardi, V, additional, Maggio, M C, additional, Mandrile, G, additional, Manieri, C, additional, Mantovani, G, additional, Marelli, S, additional, Marzullo, M, additional, Mencarelli, M A, additional, Migone, N, additional, Motta, G, additional, Neri, G, additional, Padova, G, additional, Parenti, G, additional, Pasquino, B, additional, Pia, A, additional, Piantanida, E, additional, Pignatti, E, additional, Pilotta, A, additional, Pivetta, B, additional, Pollazzon, M, additional, Pontecorvi, A, additional, Porcelli, P, additional, Pozzan, G B, additional, Pozzobon, G, additional, Radetti, G, additional, Razzore, P, additional, Rocchetti, L, additional, Roncoroni, R, additional, Rossi, G, additional, Sala, E, additional, Salvatoni, A, additional, Salvini, F, additional, Secco, A, additional, Segni, M, additional, Selice, R, additional, Sgaramella, P, additional, Sileo, F, additional, Sinisi, A A, additional, Sirchia, F, additional, Spada, A, additional, Tresoldi, A, additional, Vigneri, R, additional, Weber, G, additional, and Zucchini, S, additional

Published
2018
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