241 results on '"Arnér, Elias S.J."'
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2. Arsenic exposure and increased C-reactive protein are independently associated with lower erythrocyte glutathione peroxidase activity in Bangladeshi children
3. TXNL1 has dual functions as a redox active thioredoxin-like protein as well as an ATP- and redox-independent chaperone
4. Clozapine suppresses NADPH oxidase activation, counteracts cytosolic H2O2, and triggers early onset mitochondrial dysfunction during adipogenesis of human liposarcoma SW872 cells
5. Development of an assay pipeline for the discovery of novel small molecule inhibitors of human glutathione peroxidases GPX1 and GPX4
6. The ferroptosis inducing compounds RSL3 and ML162 are not direct inhibitors of GPX4 but of TXNRD1
7. Cardiolipin drives the catalytic activity of GPX4 on membranes: Insights from the R152H mutant
8. Selective cellular probes for mammalian thioredoxin reductase TrxR1: Rational design of RX1, a modular 1,2-thiaselenane redox probe
9. Thioredoxin and glutathione reductases
10. Contributors
11. Expressing recombinant selenoproteins using redefinition of a single UAG codon in an RF1-depleted E. coli host strain
12. To inhibit TrxR1 is to inactivate STAT3–Inhibition of TrxR1 enzymatic function by STAT3 small molecule inhibitors
13. Contributors
14. Perspectives of TrxR1-based cancer therapies
15. NADPH-dependent and -independent disulfide reductase systems
16. The A to Z of modulated cell patterning by mammalian thioredoxin reductases
17. Piperazine-Fused Cyclic Disulfides Unlock High-Performance Bioreductive Probes of Thioredoxins and Bifunctional Reagents for Thiol Redox Biology.
18. Is there a substrate specificity of glutathione peroxidase isoforms?
19. Thioredoxin reductase selenoproteins from different organisms as potential drug targets for treatment of human diseases
20. H2O2, Thioredoxin, and Signaling
21. Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy
22. Chapter Five: Targeting the Selenoprotein Thioredoxin Reductase 1 for Anticancer Therapy
23. Biochemical and structural characterizations of thioredoxin reductase selenoproteins of the parasitic filarial nematodes Brugia malayi and Onchocerca volvulus
24. Thioredoxin Reductase Inhibition for Cancer Therapy
25. Redox regulation of PTPN22 affects the severity of T cell dependent autoimmune inflammation
26. TRP14 deficiency markedly reduces the inflammatory response in acute pancreatitis through Nrf2 activation
27. Comprehensive chemical proteomics analyses reveal that the new TRi-1 and TRi-2 compounds are more specific thioredoxin reductase 1 inhibitors than auranofin
28. Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities
29. Production and purification of homogenous recombinant human selenoproteins reveals a unique codon skipping event in E. coli and GPX4-specific affinity to bromosulfophthalein
30. Crystal Structure and Catalysis of the Selenoprotein Thioredoxin Reductase 1
31. High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy
32. Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1
33. Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates
34. Sepp1UF forms are N-terminal selenoprotein P truncations that have peroxidase activity when coupled with thioredoxin reductase-1
35. In Memoriam Arne Holmgren (1940–2020)
36. SIESTA as a universal unbiased proteomics approach for identification and prioritization of enzyme substrates
37. Qualitative Differences in Protection of PTP1B Activity by the Reductive Trx1 or TRP14 Enzyme Systems upon Oxidative Challenges with Polysulfides or H2O2 Together with Bicarbonate
38. Wobble decoding by the Escherichia coli selenocysteine insertion machinery
39. A Txnrd1-dependent metabolic switch alters hepatic lipogenesis, glycogen storage, and detoxification
40. Redox activation of Fe(III)–thiosemicarbazones and Fe(III)–bleomycin by thioredoxin reductase: specificity of enzymatic redox centers and analysis of reactive species formation by ESR spin trapping
41. Studies of an active site mutant of the selenoprotein thioredoxin reductase: The Ser-Cys-Cys-Ser motif of the insect orthologue is not sufficient to replace the Cys-Sec dyad in the mammalian enzyme
42. Pyrroloquinoline quinone modulates the kinetic parameters of the mammalian selenoprotein thioredoxin reductase 1 and is an inhibitor of glutathione reductase
43. Hepatocyte DNA replication in growing liver requires either glutathione or a single allele of txnrd1
44. Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay
45. Substrate and inhibitor specificities differ between human cytosolic and mitochondrial thioredoxin reductases: Implications for development of specific inhibitors
46. Comprehensive chemical proteomics for target deconvolution of the redox active drug auranofin
47. Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone
48. Common modifications of selenocysteine in selenoproteins
49. Selenoproteins—What unique properties can arise with selenocysteine in place of cysteine?
50. Red wine triggers cell death and thioredoxin reductase inhibition: Effects beyond resveratrol and SIRT1
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