1,560 results on '"Armaganidis A"'
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2. Success stories about severe pneumonia caused by Panton–Valentine leucocidin-producing Staphylococcus aureus
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Paramythiotou Elisabeth, Souli Maria, Galani Irene, Giamarellou Helen, and Armaganidis Apostolos
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Infectious and parasitic diseases ,RC109-216 ,Microbiology ,QR1-502 - Abstract
We describe three cases of community-acquired necrotizing pneumonia which were caused by Panton–Valentine leucocidin-producing strains of Staphylococcus aureus (one of them methicillin sensitive). All cases were successfully treated without any sequelae for the patients due to the prompt initiation of adequate antimicrobial therapy. High suspicion toward this fatal pathogen was the key to the successful outcome of the patients. Keywords: Community-acquired pneumonia, Clindamycin, Staphylococcus aureus, Panton–Valentine leukocidin
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- 2014
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3. Treatment of invasive candidiasis in the elderly: a review
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Flevari A, Theodorakopoulou M, Velegraki A, Armaganidis A, and Dimopoulos G
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emerging fungal infections ,elderly patients ,treatment ,Geriatrics ,RC952-954.6 - Abstract
Aikaterini Flevari,1 Maria Theodorakopoulou,1 Aristea Velegraki,2 Apostolos Armaganidis,1 George Dimopoulos1 1Department of Critical Care, University Hospital Attikon, Medical School, 2Mycology Laboratory, Department of Microbiology, Medical School, University of Athens, Athens, Greece Abstract: Fungi are major causes of infections among immunocompromised or hospitalized patients with serious underlying diseases and comorbidities. Candida species remain the most important cause of opportunistic infections worldwide, affecting predominantly patients over 65 years old, while they are considered to be the fourth most common cause of nosocomial bloodstream infections. The rapidly growing elderly population has specific physiological characteristics, which makes it susceptible to colonization and subsequent infection due to Candida species. Comorbidities and multidrug use should be taken into account any time the therapeutic regimen is under consideration. Different classes of antifungal drugs are available for the treatment of invasive fungal infections but echinocandins, apart from their activity against resistant strains (Candida glabrata and Candida krusei), seem to be safe, with limited adverse events and minimal drug–drug interactions in comparison to the other regimens. Therefore, these agents are strongly recommended when dealing with elderly patients suffering from an invasive form of Candida infection. Keywords: emerging fungal infections, elderly patients, treatment
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- 2013
4. Life-threatening aortic thrombosis in a trauma patient homozygous for factor V Leiden mutation: Case report
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Kopterides Petros, Tsantes Argirios, Tsaknis Georgios, Tsangaris Iraklis, and Armaganidis Apostolos
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Abstract We report a case of near fatal aortic thrombosis in a trauma patient homozygous for mutation of Factor V Leiden. He responded well to vascular surgery and intensive care unit management and was discharged successfully from the hospital one month later.
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- 2011
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5. Static and dynamic mechanics of the murine lung after intratracheal bleomycin
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Papiris Spyridon, Roussos Charis, Karabela Sophia P, Psallidas Ioannis, Kotanidou Anastasia, Triantafillidou Christina, Moschos Charalampos, Manali Effrosyni D, Armaganidis Apostolos, Stathopoulos Georgios T, and Maniatis Nikolaos A
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Diseases of the respiratory system ,RC705-779 - Abstract
Abstract Background Despite its widespread use in pulmonary fibrosis research, the bleomycin mouse model has not been thoroughly validated from a pulmonary functional standpoint using new technologies. Purpose of this study was to systematically assess the functional alterations induced in murine lungs by fibrogenic agent bleomycin and to compare the forced oscillation technique with quasi-static pressure-volume curves in mice following bleomycin exposure. Methods Single intratracheal injections of saline (50 μL) or bleomycin (2 mg/Kg in 50 μL saline) were administered to C57BL/6 (n = 40) and Balb/c (n = 32) mice. Injury/fibrosis score, tissue volume density (TVD), collagen content, airway resistance (RN), tissue damping (G) and elastance coefficient (H), hysteresivity (η), and area of pressure-volume curve (PV-A) were determined after 7 and 21 days (inflammation and fibrosis stage, respectively). Statistical hypothesis testing was performed using one-way ANOVA with LSD post hoc tests. Results Both C57BL/6 and Balb/c mice developed weight loss and lung inflammation after bleomycin. However, only C57BL/6 mice displayed cachexia and fibrosis, evidenced by increased fibrosis score, TVD, and collagen. At day 7, PV-A increased significantly and G and H non-significantly in bleomycin-exposed C57BL/6 mice compared to saline controls and further increase in all parameters was documented at day 21. G and H, but not PV-A, correlated well with the presence of fibrosis based on histology, TVD and collagen. In Balb/c mice, no change in collagen content, histology score, TVD, H and G was noted following bleomycin exposure, yet PV-A increased significantly compared to saline controls. Conclusions Lung dysfunction in the bleomycin model is more pronounced during the fibrosis stage rather than the inflammation stage. Forced oscillation mechanics are accurate indicators of experimental bleomycin-induced lung fibrosis. Quasi-static PV-curves may be more sensitive than forced oscillations at detecting inflammation and fibrosis.
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- 2011
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6. Metabolic acidosis may be as protective as hypercapnic acidosis in an ex-vivo model of severe ventilator-induced lung injury: a pilot study
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Patsouris Efstratios, Agrogiannis George, Kopterides Petros, Metaxas Eugenios I, Siempos Ilias I, Kapetanakis Theodoros, Lazaris Andreas C, Stravodimos Konstantinos G, Roussos Charis, and Armaganidis Apostolos
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Anesthesiology ,RD78.3-87.3 - Abstract
Abstract Background There is mounting experimental evidence that hypercapnic acidosis protects against lung injury. However, it is unclear if acidosis per se rather than hypercapnia is responsible for this beneficial effect. Therefore, we sought to evaluate the effects of hypercapnic (respiratory) versus normocapnic (metabolic) acidosis in an ex vivo model of ventilator-induced lung injury (VILI). Methods Sixty New Zealand white rabbit ventilated and perfused heart-lung preparations were used. Six study groups were evaluated. Respiratory acidosis (RA), metabolic acidosis (MA) and normocapnic-normoxic (Control - C) groups were randomized into high and low peak inspiratory pressures, respectively. Each preparation was ventilated for 1 hour according to a standardized ventilation protocol. Lung injury was evaluated by means of pulmonary edema formation (weight gain), changes in ultrafiltration coefficient, mean pulmonary artery pressure changes as well as histological alterations. Results HPC group gained significantly greater weight than HPMA, HPRA and all three LP groups (P = 0.024), while no difference was observed between HPMA and HPRA groups regarding weight gain. Neither group differ on ultrafiltration coefficient. HPMA group experienced greater increase in the mean pulmonary artery pressure at 20 min (P = 0.0276) and 40 min (P = 0.0012) compared with all other groups. Histology scores were significantly greater in HP vs. LP groups (p < 0.001). Conclusions In our experimental VILI model both metabolic acidosis and hypercapnic acidosis attenuated VILI-induced pulmonary edema implying a mechanism other than possible synergistic effects of acidosis with CO2 for VILI attenuation.
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- 2011
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7. Diagnostic and prognostic value of procalcitonin among febrile critically ill patients with prolonged ICU stay
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Giamarellos-Bourboulis Evangelos, Orfanos Stylianos, Dimopoulou Ioanna, Tsaknis George, Kopterides Petros, Tsantes Argirios, Gourgoulis George, Kavatha Dimitra, Plachouras Diamantis, Tsangaris Iraklis, Giamarellou Helen, and Armaganidis Apostolos
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Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Procalcitonin (PCT) has been proposed as a diagnostic and prognostic sepsis marker, but has never been validated in febrile patients with prolonged ICU stay. Methods Patients were included in the study provided they were hospitalised in the ICU for > 10 days, were free of infection and presented a new episode of SIRS, with fever >38°C being obligatory. Fifty patients fulfilled the above criteria. PCT was measured daily during the ICU stay. The primary outcome was proven infection. Results Twenty-seven out of 50 patients were diagnosed with infection. Median PCT on the day of fever was 1.18 and 0.17 ng/ml for patients with and without proven infections (p < 0.001). The area under the curve for PCT was 0.85 (95% CI; 0.71-0.93), for CRP 0.65 (0.46-0.78) and for WBC 0.68 (0.49-0.81). A PCT level of 1 ng/mL yielded a negative predictive value of 72% for the presence of infection, while a PCT of 1.16 had a specificity of 100%. A two-fold increase of PCT between fever onset and the previous day was associated with proven infection (p 0.001) (OR = 8.55; 2.4-31.1), whereas a four-fold increase of PCT of any of the 6 preceding days was associated with a positive predictive value exceeding 69.65%. A PCT value less than 0.5 ng/ml on the third day after the advent of fever was associated with favorable survival (p 0.01). Conclusion The reported data support that serial serum PCT may be a valuable diagnostic and prognostic marker in febrile chronic critically ill patients.
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- 2009
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8. Kinetics of progenitor hemopoetic stem cells in sepsis: Correlation with patients survival?
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Drakoulis Nikolaos, Koroneos Apostolos, Kontogiorgi Marina, Tampaki Ekaterini-Christina, Pelekanou Aimilia, Karagianni Vassiliki, Zervakis Dimitrios, Kollias Spyridon, Giamarellos-Bourboulis Evangelos J, Tsaganos Thomas, Armaganidis Apostolos, Roussos Charis, and Giamarellou Helen
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Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Current theories underline the crucial role of pro-inflammatory mediators produced by monocytes for the pathogenesis of sepsis. Since monocytes derive from progenitor hemopoetic cells, the kinetics of stem cells was studied in peripheral blood of patients with sepsis. Methods Blood was sampled from 44 patients with septic syndrome due to ventilator-associated pneumonia on days 1, 3, 5 and 7 upon initiation of symptoms. Concentrations of tumour necrosis factor-alpha (TNFα), interleukin (IL)-6, IL-8 and G-CSF were estimated by ELISA. CD34/CD45 cells were determined after incubation with anti-CD45 FITC and anti-CD34 PE monocloncal antibodies and flow cytometric analysis. Samples from eight healthy volunteers served as controls. Results Median of CD34/CD45 absolute count of controls was 1.0/μl. Respective values of the total study population were 123.4, 112.4, 121.5 and 120.9/μl on days 1, 3, 5 and 7 (p < 0.0001 compared to controls). Positive correlations were found between the absolute CD34/CD45 count and the absolute monocyte count on days 1, 5 and 7. Survival was prolonged among patients with less than 310/μl CD34/CD45 cells on day 1 compared to those with more than 310/μl of CD34/CD45 cells (p: 0.022). Hazard ratio for death due to sepsis was 5.47 (p: 0.039) for CD34/CD45 cells more than 310/μl. Median IL-6 on day 1 was 56.78 and 233.85 pg/ml respectively for patients with less than 310/μl and more than 310/μl CD34/CD45 cells (p: 0.021). Conclusion Stem cells are increased in peripheral blood over all days of follow-up compared to healthy volunteers. Patients with counts on day 1 less than 310/μl are accompanied by increased survival compared to patients with more than 310/μl.
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- 2006
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9. Protocol for an international, multicentre, prospective, observational study of nosocomial pneumonia in intensive care units: The pneumoINSPIRE study
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Koulenti, Despoina, Armaganidis, Apostolos, Arvaniti, Kostoula, Blot, Stijn, Brun-Buisson, Christian, Deja, Maria, de Waele, Jan, Du, Bin, Dulhunty, Joel M, Garcia-Diaz, Julia, Judd, Matthew, Paterson, David L, Putensen, Christian, Reina, Rosa, Rello, Jordi, Restrepo, Marcos I, Roberts, Jason A, Sjovall, Fredrik, Timsit, Jean-Francois, Tsiodras, Sotirios, Zahar, Jean-Ralph, Zhang, Yuchi, and Lipman, Jeffrey
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- 2021
10. Demographic and clinical features of critically ill patients with COVID-19 in Greece: The burden of diabetes and obesity
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Halvatsiotis, P., Kotanidou, A., Tzannis, K., Jahaj, E., Magira, E., Theodorakopoulou, M., Konstandopoulou, G., Gkeka, E., Pourzitaki, C., Kapravelos, N., Papoti, S., Sileli, M., Gogos, C., Velissaris, D., Markou, N., Stefanatou, E., Vlachogianni, G., Aimoniotou, E., Komnos, A., Zafeiridis, T., Koulouvaris, P., Armaganidis, A., Bamias, A., and Dimopoulos, G.
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- 2020
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11. Survivin and caspases serum protein levels and survivin variants mRNA expression in sepsis
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Miliaraki, Marianna, Briassoulis, Panagiotis, Ilia, Stavroula, Polonifi, Aikaterini, Mantzourani, Marina, Briassouli, Efrossini, Vardas, Konstantinos, Nanas, Serafim, Pistiki, Aikaterini, Theodorakopoulou, Maria, Tavladaki, Theonymfi, Spanaki, Anna Maria, Kondili, Eumorfia, Dimitriou, Helen, Tsiodras, Sotirios, Georgopoulos, Dimitrios, Armaganidis, Apostolos, Daikos, George, and Briassoulis, George
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- 2021
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12. Prognostic Role of Soluble Urokinase Plasminogen Activator Receptor at the Emergency Department: A Position Paper by the Hellenic Sepsis Study Group
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Velissaris, Dimitrios, Dimopoulos, George, Parissis, John, Alexiou, Zoi, Antonakos, Nikolaos, Babalis, Dimitrios, Gerakari, Styliani, Kaldis, Vassileios, Koutoukas, Pantelis, Lada, Malvina, Leventogiannis, Konstantinos, Pantazopoulos, Ioannis, Papadopoulos, Antonios, Polyzogopoulou, Eftihia, Gogos, Charalambos, Armaganidis, Apostolos, and Giamarellos-Bourboulis, Evangelos J.
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- 2020
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13. A Hospital Information System Application May Facilitate Staff Compliance with Quality Protocols in a Medical Unit: A Case Study.
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Irene Karampela, Evangelos Tzortzis, Markos Nikolopoulos, Maria Dalamaga, Marianna Diomidous, and Apostolos Armaganidis
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- 2018
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14. The respiratory effect of tracheal gas insufflation (TGI) on tracheostomized spontaneously breathing ICU patients
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Grigoriadis, K., Tsangaris, I., Koutsoukou, A., Kopterides, P., Grammatopoulou, E., Grigoriadou, A., and Armaganidis, A.
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- 2018
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15. Prognostic value of serum omentin-1 in critically ill patients with sepsis
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Karampela, Irene, primary, Christodoulatos, Gerasimos-Socrates, additional, Vallianou, Natalia, additional, Tsilingiris, Dimitrios, additional, Antonakos, Georgios, additional, Marinou, Ioanna, additional, Vogiatzakis, Evaggelos, additional, Armaganidis, Apostolos, additional, and Dalamaga, Maria, additional
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- 2023
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16. A prospective study of circulating omentin-1 in critically ill patients with sepsis
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Karampela, Irene, primary, Vallianou, Natalia, additional, Christodoulatos, Gerasimos-Socrates, additional, Tsilingiris, Dimitrios, additional, Antonakos, Georgios, additional, Marinou, Ioanna, additional, Vogiatzakis, Evaggelos, additional, Armaganidis, Apostolos, additional, and Dalamaga, Maria, additional
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- 2023
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17. Proposal for the Implementation of Quality Standards in a Medical Unit Through Integration to the Hospital Information System.
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Irene Karampela, Evangelos Tzortzis, Ioanna Kefala, Eleutheria Zygoura, Vasiliki Mantzana, and Apostolos Armaganidis
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- 2017
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18. Reduced circulating B cells and plasma IgM levels are associated with decreased survival in sepsis - A meta-analysis
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Krautz, Christian, Maier, Sarah L., Brunner, Maximilian, Langheinrich, Melanie, Giamarellos-Bourboulis, Evangelos J., Gogos, Charalambos, Armaganidis, Apostolos, Kunath, Frank, Grützmann, Robert, and Weber, Georg F.
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- 2018
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19. Kinetics of circulating fetuin-A may predict mortality independently from adiponectin, high molecular weight adiponectin and prognostic factors in critically ill patients with sepsis: A prospective study
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Karampela, Irene, Kandri, Evangelia, Antonakos, Georgios, Vogiatzakis, Evangelos, Christodoulatos, Gerasimos Socrates, Nikolaidou, Athina, Dimopoulos, George, Armaganidis, Apostolos, and Dalamaga, Maria
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- 2017
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20. Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients
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Karampela, Irene, primary, Vallianou, Natalia G., additional, Tsilingiris, Dimitrios, additional, Christodoulatos, Gerasimos Socrates, additional, Antonakos, Georgios, additional, Marinou, Ioanna, additional, Vogiatzakis, Evaggelos, additional, Armaganidis, Apostolos, additional, and Dalamaga, Maria, additional
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- 2023
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21. The haemostatic profile in critically ill COVID-19 patients receiving therapeutic anticoagulant therapy: An observational study
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Tsantes, Argirios E., Frantzeskaki, Frantzeska, Tsantes, Andreas G., Rapti, Evdoxia, Rizos, Michalis, Kokoris, Styliani I., Paramythiotou, Elizabeth, Katsadiotis, Georgios, Karali, Vassiliki, Flevari, Aikaterini, Chrysanthopoulou, Evangelia, Maratou, Eirini, Kyriakou, Elias, Gialeraki, Argyri, Bonovas, Stefanos, Dimopoulos, George, Tsangaris, Iraklis, and Armaganidis, Apostolos
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- 2020
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22. Immunoparalysis: Clinical and immunological associations in SIRS and severe sepsis patients
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Papadopoulos, Panagiotis, Pistiki, Aikaterini, Theodorakopoulou, Maria, Christodoulopoulou, Theodora, Damoraki, Georgia, Goukos, Dimitris, Briassouli, Efrossini, Dimopoulou, Ioanna, Armaganidis, Apostolos, Nanas, Serafim, Briassoulis, George, and Tsiodras, Sotirios
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- 2017
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23. Validation of the new Sepsis-3 definitions: proposal for improvement in early risk identification
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Giamarellos-Bourboulis, E.J., Tsaganos, T., Tsangaris, I., Lada, M., Routsi, C., Sinapidis, D., Koupetori, M., Bristianou, M., Adamis, G., Mandragos, K., Dalekos, G.N., Kritselis, I., Giannikopoulos, G., Koutelidakis, I., Pavlaki, M., Antoniadou, E., Vlachogiannis, G., Koulouras, V., Prekates, A., Dimopoulos, G., Koutsoukou, A., Pnevmatikos, I., Ioakeimidou, A., Kotanidou, A., Orfanos, S.E., Armaganidis, A., and Gogos, C.
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- 2017
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24. Triiodothyronine for the treatment of critically ill patients with COVID-19 infection: A structured summary of a study protocol for a randomised controlled trial
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Pantos, Constantinos, Kostopanagiotou, Georgia, Armaganidis, Apostolos, Trikas, Athanasios, Tseti, Ioulia, and Mourouzis, Iordanis
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- 2020
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25. Occupational Stress and Quality of Life among Health Professionals during the COVID-19 Pandemic
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Efstratios, Vamvakas, Ioanna, Kontogeorgou, Aggeliki, Ntaountaki, Georgia, Karkouli, Eleni, Pisimisi, Eirini, Karampekiou, Efstathios, Politis, Iordana, Moskofi, Dimitrios, Konitopoulos, Eleni, Dokoutsidou, Maria, Grigoropoulou, Maria, Theodorakopoulou, and Apostolos, Armaganidis
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General Medicine - Abstract
Introduction Healthcare professionals, due to the nature of their work, have always experienced occupational stress, depression and low quality of life, which have been aggravated during the COVID-19 pandemic. Aim A large-scale cross-sectional descriptive correlational study aimed to investigate the impact of the COVID-19 pandemic on Greek healthcare professionals’ psychological status and quality of life. Material and Methods The study was conducted at “Attikon” General University Hospital and the 2nd Health Region in Athens, Greece. An assessment of anxiety and depression was carried out using the Zung’s Self-Rating Anxiety and Depression Scale (SAS/SDS). To assess the participants’ Quality of Life (QoL) the Short Form Survey-36 (SF-36) was used. Results 147 healthcare professionals were enrolled in the study. 70.7% experienced normal stress levels, 23.8% mild, 4.8% moderate and 0.7% severe. Mild depression was experienced by 34.7%, moderate by 10.2% and severe by 1.4%, with a 53.7% showing no depressive symptoms. Women experienced higher levels of anxiety and depression (p=0.001 & 0.001 respectively), and were 5.4 times more at risk to develop anxiety [Odds Ratio (OR) 5.357, 95% Confidence Interval (CI), 1.95-14.72: p=0.001] and 3.4 depression (OR, 3.365, 95% CI, 1.59- 7.12: p=0.002). Nurses and other professionals experienced higher stress and depression levels (p=0.004 & 0.040 respectively) than doctors. Participants reporting more exhaustion exhibited higher anxiety and depression levels (p=0.001). Compared to the pre-COVID-19 era, women (p=0.001), other health professionals (p=0.001) and those experiencing more physical burnout during COVID-19 (p=0.005) reported worse physical health. Anxiety and depression were negatively correlated with most sub scales of SF-36 except social functioning and bodily pain (p=0.001). Conclusions Healthcare professionals’ QoL has been affected by the COVID-19 pandemic and they experience higher levels of anxiety and depression. There is a need to develop strategies to address the negative psychological impact of this pandemic on healthcare professionals.
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- 2022
26. Diagnostic and Prognostic Value of Serum Omentin-1 in Sepsis: A Prospective Study in Critically Ill Patients
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Irene Karampela, Natalia G. Vallianou, Dimitrios Tsilingiris, Gerasimos Socrates Christodoulatos, Georgios Antonakos, Ioanna Marinou, Evaggelos Vogiatzakis, Apostolos Armaganidis, and Maria Dalamaga
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General Medicine ,adipokine ,adipose tissue ,biomarker ,critically ill ,intelectin-1 ,mortality ,omentin-1 ,sepsis ,septic shock - Abstract
Background and Objectives: Omentin-1, also known as intelectin-1, is a novel adipokine with anti-inflammatory activities implicated in inflammatory diseases and sepsis. We aimed to explore serum omentin-1 and its kinetics in critically ill patients early in sepsis and its association with severity and prognosis. Materials and Methods: Serum omentin-1 was determined in 102 critically ill patients with sepsis during the first 48 h from sepsis onset and 1 week later, and in 102 age- and gender-matched healthy controls. The outcome of sepsis at 28 days after enrollment was recorded. Results: Serum omentin-1 at enrollment was significantly higher in patients compared to controls (763.3 ± 249.3 vs. 451.7 ± 122.3 μg/L, p < 0.001) and it further increased 1 week after (950.6 ± 215.5 vs. 763.3 ± 249.3 μg/L, p < 0.001). Patients with septic shock (n = 42) had higher omentin-1 compared to those with sepsis (n = 60) at enrollment (877.9 ± 241.2 vs. 683.1 ± 223.7 μg/L, p < 0.001) and 1 week after (1020.4 ± 224.7 vs. 901.7 ± 196.3 μg/L, p = 0.007). Furthermore, nonsurvivors (n = 30) had higher omentin-1 at sepsis onset (952.1 ± 248.2 vs. 684.6 ± 204.7 μg/L, p < 0.001) and 1 week after (1051.8 ± 242 vs. 908.4 ± 189.8 μg/L, p < 0.01). Patients with sepsis and survivors presented higher kinetics than those with septic shock and nonsurvivors (Δ(omentin-1)% 39.8 ± 35.9% vs. 20.2 ± 23.3%, p = 0.01, and 39.4 ± 34.3% vs. 13.3 ± 18.1%, p < 0.001, respectively). Higher omentin-1 at sepsis onset and 1 week after was an independent predictor of 28-day mortality (HR 2.26, 95% C.I. 1.21–4.19, p = 0.01 and HR: 2.15, 95% C.I. 1.43–3.22, p < 0.001, respectively). Finally, omentin-1 was significantly correlated with the severity scores, the white blood cells, coagulation biomarkers, and CRP, but not procalcitonin and other inflammatory biomarkers. Conclusions: Serum omentin-1 is increased in sepsis, while higher levels and lower kinetics during the first week of sepsis are associated with the severity and 28-day mortality of sepsis. Omentin-1 may be a promising biomarker of sepsis. However, more studies are needed to explore its role in sepsis.
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- 2023
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27. Phlegmonous Gastritis and Streptoccocal Toxic Shock Syndrome: An Almost Lethal Combination
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Antoniadou Anastasia, Elisabeth Paramythiotou, Mitrakou Cornelia, Armaganidis Apostolos, Savva Athinna, and Dimopoulos George
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medicine.medical_specialty ,business.industry ,Septic shock ,Toxic shock syndrome ,Case Report ,Multi-organ failure ,Critical Care and Intensive Care Medicine ,medicine.disease ,Multiorgan failure ,Gastroenterology ,Streptococcus group A ,Phlegmonous gastritis ,Internal medicine ,Medicine ,business - Abstract
We report a case of phlegmonous gastritis in a 70-year-old woman without any predisposing factors, presenting with high fever, epigastric pain, and vomiting complicated by septic shock and multi-organ failure. The ultrasound and the computed tomography scan showed thickening of the stomach wall. Streptococcus pyogenes was isolated in the blood, thereby establishing the diagnosis of streptococcal toxic shock syndrome. An exploratory laparotomy excluded the need for a gastrectomy, and the patient was successfully treated with antibiotics. A short review of phlegmonous gastritis caused by S. pyogenes during the last 12 years is also presented. How to cite this article: Elisabeth P, Cornelia M, Athinna S, Anastasia A, Apostolos A, George D. Phlegmonous Gastritis and Streptoccocal Toxic Shock Syndrome: An Almost Lethal Combination. Indian J Crit Care Med 2021;25(10):1197–1200.
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- 2022
28. Factors Associated with Interruptions of Enteral Nutrition and the Impact on Macro- and Micronutrient Deficits in ICU Patients
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Kasti, Arezina N., primary, Theodorakopoulou, Maria, additional, Katsas, Konstantinos, additional, Synodinou, Kalliopi D., additional, Nikolaki, Maroulla D., additional, Zouridaki, Alice Efstathia, additional, Fotiou, Stylianos, additional, Kapetani, Aliki, additional, and Armaganidis, Apostolos, additional
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- 2023
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29. Improving outcomes of severe infections by multidrug-resistant pathogens with polyclonal IgM-enriched immunoglobulins
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Giamarellos-Bourboulis, E.J., Tziolos, N., Routsi, C., Katsenos, C., Tsangaris, I., Pneumatikos, I., Vlachogiannis, G., Theodorou, V., Prekates, A., Antypa, E., Koulouras, V., Kapravelos, N., Gogos, C., Antoniadou, E., Mandragos, K., and Armaganidis, A.
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- 2016
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30. Calibration of a microdialysis sensor and recursive glucose level estimation in ICU patients using Kalman and particle filtering
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Charalampidis, Alexandros C., Pontikis, Konstantinos, Mitsis, Georgios D., Dimitriadis, George, Lampadiari, Vaia, Marmarelis, Vasilis Z., Armaganidis, Apostolos, and Papavassilopoulos, George P.
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- 2016
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31. Calibration of a microdialysis sensor and recursive glucose level estimation in ICU patients using Kalman and particle filtering.
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Alexandros C. Charalampidis, Konstantinos Pontikis, Georgios D. Mitsis, George Dimitriadis, Vaia Lampadiari, Vasilis Z. Marmarelis, Apostolos Armaganidis, and George P. Papavassilopoulos
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- 2016
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32. Cytomegalovirus reactivation in a general, nonimmunosuppressed intensive care unit population: Incidence, risk factors, associations with organ dysfunction, and inflammatory biomarkers
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Frantzeskaki, Frantzeska G., Karampi, Eirini-Sofia, Kottaridi, Christina, Alepaki, Maria, Routsi, Christina, Tzanela, Marinella, Vassiliadi, Dimitra Argyro, Douka, Evangelia, Tsaousi, Sofia, Gennimata, Vasiliki, Ilias, Ioannis, Nikitas, Nikitas, Armaganidis, Apostolos, Karakitsos, Petros, Papaevangelou, Vassiliki, and Dimopoulou, Ioanna
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- 2015
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33. Critical care admission following elective surgery was not associated with survival benefit: prospective analysis of data from 27 countries
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Kahan, Brennan C., Koulenti, Desponia, Arvaniti, Kostoula, Beavis, Vanessa, Campbell, Douglas, Chan, Matthew, Moreno, Rui, Pearse, Rupert M., Pearse, Rupert M., Beattie, Scott, Clavien, Pierre-Alain, Demartines, Nicolas, Fleisher, Lee A., Grocott, Mike, Haddow, James, Hoeft, Andreas, Holt, Peter, Moreno, Rui, Pritchard, Naomi, Rhodes, Andrew, Wijeysundera, Duminda, Wilson, Matt, Ahmed, Tahania, Everingham, Kirsty, Hewson, Russell, Januszewska, Marta, Pearse, Rupert M., Phull, Mandeep-Kaur, Halliwell, Richard, Shulman, Mark, Myles, Paul, Schmid, Werner, Hiesmayr, Michael, Wouters, Patrick, de Hert, Stefan, Lobo, Suzana, Beattie, Scott, Wijeysundera, Duminda, Fang, Xiangming, Rasmussen, Lars, Futier, Emmanuel, Biais, Matthieu, Venara, Aurélien, Slim, Karem, Sander, Michael, Koulenti, Despoina, Arvaniti, Kostoula, Chan, Mathew, Kulkarni, Atul, Chandra, Susilo, Tantri, Aida, Geddoa, Emad, Abbas, Muntadhar, Della Rocca, Giorgio, Sivasakthi, Datin, Mansor, Marzida, Luna, Pastor, Bouwman, Arthur, Buhre, Wolfgang, Beavis, Vanessa, Campbell, Douglas, Short, Tim, Osinaike, Tunde, Matos, Ricardo, Grigoras, Ioana, Kirov, Mikhail, Protsenko, Denis, Biccard, Bruce, Aldecoa, Cesar, Chew, Michelle, Hofer, Christoph, Hubner, Martin, Ditai, James, Szakmany, Tamas, Fleisher, Lee, Ferguson, Marissa, MacMahon, Michael, Shulman, Mark, Cherian, Ritchie, Currow, Helen, Kanathiban, Kathirgamanathan, Gillespie, David, Pathmanathan, Edward, Phillips, Katherine, Reynolds, Jenifer, Rowley, Joanne, Douglas, Jeanene, Kerridge, Ross, Currow, Helen, Garg, Sameer, Bennett, Michael, Jain, Megha, Alcock, David, Terblanche, Nico, Cotter, Rochelle, Leslie, Kate, Stewart, Marcelle, Zingerle, Nicolette, Clyde, Antony, Hambidge, Oliver, Rehak, Adam, Cotterell, Sharon, Binh QuanHuynh, Wilson, McCulloch, Timothy, Ben-Menachem, Erez, Egan, Thomas, Cope, Jennifer, Halliwell, Richard, Fellinger, Paul, Haselberger, Simone, Holaubek, Caroline, Lichtenegger, Paul, Scherz, Florian, Schmid, Werner, Hoffer, Franz, Cakova, Veronika, Eichwalder, Andreas, Fischbach, Norbert, Klug, Reinhold, Schneider, Elisabeth, Vesely, Martin, Wickenhauser, Reinhart, Grubmueller, Karl Gernot, Leitgeb, Marion, Lang, Friedrich, Toro, Nancy, Bauer, Marlene, Laengle, Friedrich, Mayrhofer, Thomas, Buerkle, Christian, Forstner, Karin, Germann, Reinhard, Rinoesl, Harald, Schindler, Elke, Trampitsch, Ernst, Fritsch, Gerhard, Szabo, Christian, Bidgoli, Jawad, Verdoodt, Hans, Forget, Patrice, Kahn, David, Lois, Fernande, Momeni, Mona, Prégardien, Caroline, Pospiech, Audrey, Steyaert, Arnaud, Veevaete, Laurent, De Kegel, Dirk, De Jongh, Karen, Foubert, Luc, Smitz, Carine, Vercauteren, Marcel, Poelaert, Jan, Van Mossevelde, Veerle, Abeloos, Jacques, Bouchez, Stefaan, Coppens, Marc, De Baerdemaeker, Luc, Deblaere, Isabel, De Bruyne, Ann, De Hert, Stefan, Fonck, Kristine, Heyse, Bjorn, Jacobs, Tom, Lapage, Koen, Moerman, Anneliese, Neckebroek, Martine, Parashchanka, Aliaksandra, Roels, Nathalie, Van Den Eynde, Nancy, Vandenheuvel, Michael, Van Limmen, Jurgen, Vanluchene, Ann, Vanpeteghem, Caroline, Wouters, Patrick, Wyffels, Piet, Huygens, Christel, Vandenbempt, Punitha, Van de Velde, Marc, Dylst, Dimitri, Janssen, Bruno, Schreurs, Evelien, Aleixo, Fábia Berganton, Candido, Keulle, Dias Batista, Hugo, Guimarães, Mario, Guizeline, Jaqueline, Hoffmann, João, Lobo, Suzana M., Lobo, Francisco Ricardo, Nascimento, Vinícius, Nishiyama, Katia, Pazetto, Lucas, Souza, Daniela, Souza Rodrigues, Rodrigo, Vilela dos Santos, Ana Maria, Jardim, Jaquelline, Silva, Joao, do NascimentoJunior, Paulo, Baio, Thalissa Hermínia, Pereira de Castro, Gabriel Isaac, Watanabe Oliveira, Henri Roger, Amendola, Cristina Prata, Cardoso, Gutemberg, Ortega, Daniela, Brotto, Ana Flavia, De Oliveira, Mirella Cristine, Réa-Neto, Álvaro, Dias, Fernando, Azambuja, Pedro, Knibel, Marcos Freitas, Martins, Antonio, Almeida, William, Neto, Calim Neder, Tardelli, Maria Angela, Caser, Eliana, Machado, Marcio, Aguzzoli, Crisitiano, Baldisserotto, Sérgio, Beck Tabajara, Fernanda, Bettega, Fernanda, Rodrigues Júnior, La Hore Correa, de Gasperi, Julia, Faina, Lais, Nolasco, Marcos Farias, da Costa Fischer, Bruna Ferreira, de Campos Ferreira, Mariana Fosch, Hartmann, Cristina, Kliemann, Marta, Ribeiro, Gustavo LuisHubert, Fraga, Julia Merladete, Netto, Thiago Motta, Pozza, Laura Valduga, Wendling, Paulo Rafael, Azevedo, Caroline, Garcia, Juliana, Lopes, Marcel, Maia, Bernardo, Maselli, Paula, Melo, Ralph, Mendes, Weslley, Neves, Matheus, Ney, Jacqueline, Piras, Claudio, Applewhaite, Christopher, Carr, Adrienne, Chow, Lorraine, Duttchen, Kaylene, Foglia, Julena, Greene, Michael, Hinther, Ashley, Houston, Kendra, McCormick, Thomas Jared, Mikhayel, Jennifer, Montasser, Sam, Ragan, Alex, Suen, Andrew, Woolsey, Adrianna, Yu, Hai Chuan, Funk, Duane, Kowalski, Stephen, Legaspi, Regina, McDonald, Heather, Siddiqui, Faisal, Pridham, Jeremy, Rowe, Bernadette, Sampson, Sonia, Thiessen, Barton, Zbitnew, Geoff, Bernard, Andre, George, Ronald, Jones, Philip, Moor, Rita, Siddiqui, Naveed, Wolfer, Alexandra, Tran, Diem, Winch, Denyse, Dobson, Gary, Hinther, Ashley, McCormick, Thomas, Montasser, Osama, Suen, Andrew, Woolsey, Adrianna, Bernard, Andre, George, Ronald, Hall, Richard, Bernard, Andre, George, Ronald, Hall, Richard, Applewhaite, Christopher, Baghirzada, Leyla, McCormick, Thomas Jared, Suen, Andrew, Dai, Si Yuan, Hare, Gregory, Lee, Esther, Shastri, Uma, Tsui, Albert, Yagnik, Anmol, Alvares, Danielle, Choi, Stephen, Dwyer, Heather, Flores, Kathrina, McCartney, Colin, Somascanthan, Priya, Beattie, Scott, Carroll, Jo, Pazmino-Canizares, Janneth, Wijeysundera, Duminda, Wolfer, Alexandra, Ami, Noam, Chan, Vincent, Perlas, Anahi, Argue, Ruth, Lavis, Katie, Mayson, Kelly, Cao, Ying, Gao, Hong, hu, tingju, Lv, Jie, Yang, Jian, Yang, Yang, Zhong, Yi, Zhou, Jing, Zou, Xiaohua, He, Miao, Li, Xiaoying, Luo, Dihuan, Wang, Haiying, Yu, Tian, Chen, Liyong, Wang, Lijun, Cai, Yunfei, Cao, Zhongming, Li, Yanling, Lian, Jiaxin, Sun, Haiyun, Wang, Sheng, Wang, Zhipeng, Wang, Kenru, Zhu, Yi, Du, Xindan, Fan, Hao, Fu, Yunbin, Huang, Lixia, Huang, Yanming, Hwan, Haifang, Luo, Hong, Qu, Pi-Sheng, Tao, Fan, Wang, Zhen, Wang, Guoxiang, Wang, Shun, Zhang, Yan, Zhang, Xiaolin, Chen, Chao, Wang, Weixing, Liu, Zhengyuan, Fan, Lihua, Tang, Jing, Chen, Yijun, Chen, Yongjie, Han, Yangyang, Huang, Changshun, Liang, Guojin, Shen, Jing, Wang, Jun, Yang, Qiuhong, Zhen, Jungang, Zhou, Haidong, Chen, Junping, Chen, Zhang, Li, Xiaoyu, Meng, Bo, Ye, Haiwang, Zhang, Xiaoyan, Bi, Yanbing, Cao, Jianqiao, Guo, Fengying, Lin, Hong, Liu, Yang, Lv, Meng, Shi, Pengcai, Song, Xiumei, Sun, Chuanyu, Sun, Yongtao, Wang, Yuelan, Wang, Shenhui, Zhang, Min, Chen, Rong, Hou, Jiabao, Leng, Yan, Meng, Qing-tao, Qian, Li, Shen, Zi-ying, Xia, Zhong-yuan, Xue, Rui, Zhang, Yuan, Zhao, Bo, Zhou, Xian-jin, Chen, Qiang, Guo, Huinan, Guo, Yongqing, Qi, Yuehong, Wang, Zhi, Wei, Jianfeng, Zhang, Weiwei, Zheng, Lina, Bao, Qi, Chen, Yaqiu, Chen, Yijiao, Fei, Yue, Hu, Nianqiang, Hu, Xuming, Lei, Min, Li, Xiaoqin, Lv, Xiaocui, Lv, Jie, Miao, Fangfang, Ouyang, Lingling, Qian, Lu, Shen, Conyu, Sun, Yu, Wang, Yuting, Wang, Dong, Wu, Chao, Xu, Liyuan, Yuan, Jiaqi, Zhang, Lina, Zhang, Huan, Zhang, Yapping, Zhao, Jinning, Zhao, Chong, Zhao, Lei, Zheng, Tianzhao, Zhou, Dachun, Zhou, Haiyan, Zhou, Ce, Lu, Kaizhi, Zhao, Ting, He, Changlin, Chen, Hong, Chen, Shasha, Cheng, Baoli, He, Jie, Jin, Lin, Li, Caixia, Li, Hui, Pan, Yuanming, Shi, Yugang, Wen, Xiao Hong, Wu, Shuijing, Xie, Guohao, Zhang, Kai, Zhao, Bing, Lu, Xianfu, Chen, Feifei, Liang, Qisheng, Lin, Xuewu, Ling, Yunzhi, Liu, Gang, Tao, Jing, Yang, Lu, Zhou, Jialong, Chen, Fumei, Feng, Yunlin, Hou, Benchao, Lin, Jiamei, Liu, Mei, Luo, Foquan, Shi, Xiaoyun, Xiong, Yingfen, Xu, Lin, Yang, Shuangjia, Zhang, Qin, Zhang, Huaigen, Zhao, Weihong, Zhao, Weilu, Bai, Yun, Chen, Linbi, Chen, Sijia, Dai, Qinxue, Geng, Wujun, Han, Kunyuan, He, Xin, Huang, Luping, Ji, Binbin, Jia, Danyun, Jin, Shenhui, Li, Qianjun, Liang, Dongdong, Luo, Shan, Lwang, Lulu, Mo, Yunchang, Pan, Yuanyuan, Qi, Xinyu, Qian, Meizi, Qin, Jinling, Ren, Yelong, Shi, Yiyi, Wang, Junlu, Wang, Junkai, Wang, Leilei, Xie, Junjie, Yan, Yixiu, Yao, Yurui, Zhang, Mingxiao, Zhao, Jiashi, Zhuang, Xiuxiu, Ai, Yanqiu, Du, Fang, He, Long, Huang, Ledan, Li, Zhisong, Li, Huijuan, Li, Yetong, Li, Liwei, Meng, Su, Yuan, Yazhuo, Zhang, Enman, Zhang, Jie, Zhao, Shuna, Ji, Zhenrong, Pei, Ling, Wang, Li, Chen, Chen, Dong, Beibei, Li, Jing, Miao, Ziqiang, Mu, Hongying, Qin, Chao, Su, Lin, Wen, Zhiting, Xie, Keliang, Yu, Yonghao, Yuan, Fang, Hu, Xianwen, Zhang, Ye, Xiao, Wangpin, Zhu, Zhipeng, Dai, Qingqing, Fu, Kaiwen, Hu, Rong, Hu, Xiaolan, Huang, Song, Li, Yaqi, Liang, Yingping, Yu, Shuchun, Guo, Zheng, Jing, Yan, Tang, Na, Wu, Jie, Yuan, Dajiang, Zhang, Ruilin, Zhao, Xiaoying, Li, Yuhong, Bai, Hui-Ping, Liu, Chun-Xiao, Liu, Fei-Fei, Ren, Wei, Wang, Xiu-Li, Xu, Guan-Jie, Hu, Na, Li, Bo, Ou, Yangwen, Tang, Yongzhong, Yao, Shanglong, Zhang, Shihai, Kong, Cui-Cui, Liu, Bei, Wang, Tianlong, Xiao, Wei, Lu, Bo, Xia, Yanfei, Zhou, Jiali, Cai, Fang, Chen, Pushan, Hu, Shuangfei, Wang, Hongfa, Wu, Jie, Xu, Qiong, Hu, Liu, Jing, Liang, Li, Jing, Li, Bin, Liu, Qiang, Liu, Yuejiang, Lu, Xinjian, Peng, Zhen Dan, Qiu, Xiaodong, Ren, Quan, Tong, Youliang, Wang, Zhen, Wang, Jin, Wen, Yazhou, Wu, Qiong, Xia, Jiangyan, Xie, Jue, Xiong, Xiapei, Xu, Shixia, Yang, Tianqin, Ye, Hui, Yin, Ning, Yuan, Jing, Zeng, Qiuting, Zhang, Baoling, Zheng, Kang, Cang, Jing, Chen, Shiyu, Du, Fang, Fan, Yu, Fu, Shuying, Ge, Xiaodong, Guo, Baolei, Huang, Wenhui, Jiang, Linghui, Jiang, Xinmei, Jin, Lin, Liu, Yi, Pan, Yan, Ren, Yun, Shan, Qi, Wang, Jiaxing, Wang, Fei, Wu, Chi, Zhang, Xiaoguang, Christiansen, Ida Cecilie, Granum, Simon Nørgaard, Rasmussen, Bodil Steen, Daugaard, Morten, Gambhir, Rajiv, Steingrímsdóttir, Guðný Erla, Jensen-Gadegaard, Peter, Olsen, Karsten Skovgaard, Siegel, Hanna, Zwicky Eskildsen, Katrine, Gätke, Mona Ring, Wibrandt, Ida, Heintzelmann, Simon Bisgaard, Lange, Kai Henrik Wiborg, Lundsgaard, Rune Sarauw, Amstrup-Hansen, Louise, Hovendal, Claus, Larsen, Michael, Lenstrup, Mette, Kobborg, Tina, Larsen, Jens Rolighed, Pedersen, Anette Barbre, Larsen, Jens Rolighed, Smith, Søren Hübertz, Oestervig, Rebecca Monett, Rasmussen, Lars, Afshari, Arash, Andersen, Cheme, Ekelund, Kim, Secher, Erik Lilja, Brandsborg, Birgitte, Beloeil, Helene, Lasocki, Sigismond, Venara, Aurélien, Biais, Matthieu, Ouattara, Alexandre, Sineus, Marlene, Molliex, Serge, Legouge, Marie Lim, Wallet, Florent, Tesniere, Antoine, Gaudin, Christophe, Lehur, Paul, Forsans, Emma, de Rudnicki, Stéphane, Serra Maudet, Valerie, Mutter, Didier, Sojod, Ghassan, Ouaissi, Mehdi, Regimbeau, Jean-Marc, Futier, Emmanuel, Desbordes, Jacques, Comptaer, Nicolas, elManser, Diae, Ethgen, Sabine, Lebuffe, Gilles, Auer, Patrick, Härtl, Christine, Deja, Maria, Legashov, Kirill, Sonnemann, Susanne, Wiegand-Loehnert, Carola, Falk, Elke, Habicher, Marit, Angermair, Stefan, Laetsch, Beatrix, Schmidt, Katrin, Sonnemann, Susanne, Von Heymann, Christian, Ramminger, Axel, Jelschen, Florian, Pabel, Svenja, Weyland, Andreas, Czeslick, Elke, Gille, Jochen, Malcharek, Michael, Sablotzki, Armin, Lueke, Katharina, Wetzel, Peter, Weimann, Joerg, Lenhart, Franz-Peter, Reichle, Florian, Schirmer, Frederike, Hüppe, Michael, Klotz, Karl, Nau, Carla, Schön, Julika, Mencke, Thomas, Wasmund, Christina, Bankewitz, Carla, Baumgarten, Georg, Fleischer, Andreas, Guttenthaler, Vera, Hack, Yvonne, Hoeft, Andreas, Kirchgaessner, Katharina, Männer, Olja, Schurig-Urbaniak, Marlen, Struck, Rafael, vanZyl, Rebekka, Wittmann, Maria, Goebel, Ulrich, Harris, Sarah, Veit, Siegfried, Andreadaki, Evangelia, Souri, Flora, Katsiadramis, Ioannis, Skoufi, Anthi, Vasileiou, Maria, Aimoniotou-Georgiou, Eleni, Katsourakis, Anastasios, Veroniki, Fotini, Vlachogianni, Glyceria, Petra, Konstantina, Chlorou, Dimitra, Oloktsidou, Eirini, Ourailoglou, Vasileios, Papapostolou, Konstantinos, Tsaousi, Georgia, Daikou, Panagoula, Dedemadi, Georgia, Kalaitzopoulos, Ioannis, Loumpias, Christos, Bristogiannis, Sotirios, Dafnios, Nikolaos, Gkiokas, Georgios, Kontis, Elissaios, Kozompoli, Dimitra, Papailia, Aspasia, Theodosopoulos, Theodosios, Bizios, Christol, Koutsikou, Anastasia, Moustaka, Aleaxandra, Plaitakis, Ioannis, Armaganidis, Apostolos, Christodoulopoulou, Theodora, Lignos, Mihail, Theodorakopoulou, Maria, Asimakos, Andreas, Ischaki, Eleni, Tsagkaraki, Angeliki, Zakynthinos, Spyros, Antoniadou, Eleni, Koutelidakis, Ioannis, Lathyris, Dimitrios, Pozidou, Irene, Voloudakis, Nikolaos, Dalamagka, Maria, Gkonezou, Elena, Chronis, Christos, Manolakaki, Dimitra, Mosxogiannidis, Dimitris, Slepova, Tatiana, Tsakiridou, Isaia–sissy, Lampiri, Claire Lampiri, Vachlioti, Anastasia Vachlioti, Panagiotakis, Christos Panagiotakis, Sfyras, Dimitrios Sfyras, Tsimpoukas, FotiosTsimpoukas, Tsirogianni, Athanasia, Axioti, Elena, Filippopoulos, Andreas, Kalliafa, Elli, Kassavetis, George, Katralis, Petros, Komnos, Ioannis, Pilichos, Georgios, Ravani, Ifigenia, Totis, Antonis, Apagaki, Eymorfia, Efthymiadi, Andromachi, Kampagiannis, Nikolaos, Paraforou, Theoniki, Tsioka, Agoritsa, Georgiou, Georgios, Vakalos, Aristeidis, Bairaktari, Aggeliki, Charitos, Efthimios, Markou, George, Niforopoulou, Panagiota, Papakonstantinou, Nikolaos, Tsigou, Evdoxia, Xifara, Archontoula, Zoulamoglou, Menelaos, Gkioni, Panagiota, Karatzas, Stylianos, Kyparissi, Aikaterini, Mainas, Efstratios, Papapanagiotou, Ioannis, Papavasilopoulou, Theonymfi, Fragandreas, George, Georgopoulou, Eleni, Katsika, Eleni, Psarras, Kyriakos, Synekidou, Eirini, Verroiotou, Maria, Vetsiou, Evangelia, Zaimi, Donika, Anagnou, Athina, Apostolou, Konstantinos, Melissopoulou, Theodora, Rozenberg, Theophilos, Tsigris, Christos, Boutsikos, Georgios, Kalles, Vasileios, Kotsalas, Nikolaos, Lavdaiou, Christina, Paikou, Fotini, Panagou, Georgia-Laura, Spring, Anna, Arvaniti, Kostoula, Botis, Ioannis, Drimala, Maria, Georgakakis, Georgios, Kiourtzieva, Ellada, Ntouma, Panagiota, Prionas, Apostolos, Xouplidis, Kyriakos, Dalampini, Eleftheria, Giannaki, Chrysavgi, Iasonidou, Christina, Ioannidis, Orestis, Lavrentieva, Athina, Lavrentieva, Athena, Papageorgiou, George, Kokkinoy, Maria, Stafylaraki, Maria, Gaitanakis, Stylianos, Karydakis, Periclis, Paltoglou, Josef, Ponireas, Panagiotis, Chaloulis, Panagiotis, Provatidis, Athanasios, Sousana, Anisoglou, Gardikou, Varvara Vanessa, Konstantivelli, Maria, Lataniotou, Olga, Lisari, Elisavet, Margaroni, Maria, Stamatiou, Konstantinos, Nikolaidis, Edouardos, Pnevmatikos, Ioannis, Sertaridou, Eleni, Andreou, Alexandros, Arkalaki, Eleni, Athanasakis, Elias, Chaniotaki, Fotini, Chatzimichali, Aikaterini, Christofaki, Maria, Dermitzaki, Despina, Fiorentza, Klara, Frantzeskos, Georgios, Geromarkaki, Elisavet, Kafkalaki, Kalliopi, Kalogridaki, Marina, Karydi, Konstyllia, Kokkini, Sofia, Kougentakis, Georgios, Lefaki, Tatiana, Lilitsis, Emmanouhl, Makatounaki, Aikaterini, Malliotakis, Polychronis, Michelakis, Dimosthenis, Neonaki, Maria, Nyktari, Vasileia, Palikyra, Iliana, Papadakis, Eleftherios, Papaioannou, Alexandra, Sfakianakis, Konstantinos, Sgouraki, Maria, Souvatzis, Xenia, Spartinou, Anastasia, Stefanidou, Nefeli, Syrogianni, Paulina, Tsagkaraki, Georgia, Arnaoutoglou, Elena, Arnaoutoglou, Christina, Bali, Christina, Bouris, Vasilios, Doumos, Rodamanthos, Gkini, Konstantia-Paraskevi, Kapaktsi, Clio, Koulouras, Vasilios, Lena, Arian, Lepida, Dimitra, Michos, Evangelos, Papadopoulos, Dimitrios, Paschopoulos, Minas, Rompou, Vaia Aliki, Siouti, Ioanna, Tsampalas, Stavros, Ververidou, Ourania, Zilis, Georgios, Charlalampidoy, Alexandra, Christodoulidis, Gregory, Flossos, Andreas, Stamoulis, Konstantinos, Chan, Matthew, Tsang, Man Shing Caleb, Tsang, Man Shing, Lai, Man Ling, Yip, Chi Pang, Chan, Hey Man Heymans, Law, Bassanio, Li, Wing Sze, Chu, Hiu Man, Koo, Emily Gar Yee, Lam, Chi Cheong Joe, Cheng, Ka Ho, Chan, Matthew, Lam, Tracy, Chu, Susanna, Lai, Man Ling, Lam, Wing Yan, Wong, Kin Wai Kevin, Kwok, Dilys, Hung, Ching Yue Janice, Chan, Wai Kit Jacky, LamWong, Wing, Chung, Chun Kwong Eric, Lai, Man Ling, Ma, ShuKai, Kaushik, Shuchi, Shah, Bhagyesh, Shah, Dhiren, Shah, Sanjay, Ar, Praburaj, Muthuchellappan, Radhakrishnan, Agarwal, Vandana, Divatia, Jigeeshu, Kulkarni, Atul, Mishra, Sanghamitra, Nimje, Ganesh, Pande, Swati, Savarkar, Sukhada, Shrivastava, Aditi, Thomas, Martin, Yegnaram, Shashikant, Hidayatullah, Rahmat, Chandra, Susilo, Tantri, Aida, Puar, Nasman, Niman, Sumara, Indra, Imai, Hamzah, Zulkarnain, Yuliana, Annika, Abidin, Ucu Nurhadiat, Dursin, Ade Nurkacan, Kurnia, Andri, Susanti, Ade, Handayani, Dini, Aribawa, Mahaalit Alit, Arya, Aryabiantara, Senapathi, Tjokorda Gde Agung, Utara, Utara Hartawan, Wid, Widnyana Made, Wima, Semarawima, Wir, Wiryana Made, Jehosua, Brillyan, Kaunang, Jonathan, Lantang, Eka Yudha, Najoan, Rini, Waworuntu, Neil, Awad, Hadi, Fuad, Akram, Geddoa, Emad, Geddoa, Burair, Khalaf, Abdel Razzaq, Al hussaini, Sabah, Albaj, Safauldeensalem, Kenber, Maithem, Bettinelli, Alessandra, Spadaro, Savino, Volta, Carlo Alberto, Giancarlo, Luigi, Sottosanti, Vicari, Della Rocca, Giorgio, Spagnesi, Lorenzo, Toretti, Ilaria, Alloj, Chiara, Cardellino, Silvano, Carmino, Livio, Costanzo, Eleonora, Fanfani, Lucia Caterina, Novelli, Maria Teresa, Roasio, Agostino, Bellandi, Mattia, Beretta, Luigi, Bignami, Elena, Bocchino, Speranza, Cabrini, Luca, Corti, Daniele, Landoni, Giovanni, Meroni, Roberta, Moizo, Elena, Monti, Giacomo, Pintaudi, Margherita, Plumari, Valentina Paola, Taddeo, Daiana, Testa, Valentina, Winterton, Dario, Zangrillo, Alberto, Cloro, Luigi Maria, Colangelo, Chiara, Colangelo, Antonio, Rotunno, Giuseppe, Angel, MiguelPaludi, Maria, Cloro Paolo, Pata, Antonio, Parrini, Vieri, Gatta, Alessandro, Nastasi, Mauro, Tinti, Carla, Spagnesi, Lorenzo, Arrigo, Mario, Benevento, Angelo, Bottini, Corrado, Cannavo’, Maurizio, Gastaldi, Christian, Marchesi, Alessandro, Pascazio, Angelantonio, Pata, Francesco, Pozzi, Emilio, Premoli, Alberto, Tessera, Gaetano, Boschi, Luca, D’Andrea, Rocco, Ghignone, Federico, Poggioli, Gilberto, Sibilio, Andrea, Taffurelli, Mario, Ugolini, Giampaolo, Ab Majid, Mohd Azuan, Ab Rahman, Rusnah, Joseph, James, Pathan, Furquan, Shah, Mohammad Hafizshah Sybil, Yap, Huey Ling, Cheah, Seleen, Chin, Im Im, Looi, Ji Keon, Tan, Siew Ching, Visvalingam, Sheshendrasurian, Kwok, Fan Yin, Lee, Chew Kiok, Tan, Tse Siang, Wong, Sze Meng, Abdullah, Noor Hairiza, Liew, Chiat Fong, Luxuman, Lovenia, Mohd Zin, Nor Hafizah, Norddin, Muhamad Faiz, Alias, Raja Liza Raja, Wong, Juan Yong, Yong, Johnny, Bin Mustapha, Mohd Tarmimi, Chan, Weng Ken, Dzulkipli, Norizawati, Kuan, Pei Xuan, Lee, Yew Ching, Alias, Anita, Guok, Eng Ching, Jee, Chiun Chen, Ramon, Brian Rhadamantyne, Weng, Cheng Wong, Abd Ghafar, Fara Nur Idayu, Aziz, Faizal Zuhri, Hussain, Nabilah, Lee, Hooi Sean, Sukawi, Ismawaty, Woon, Yuan Liang, Abd Hadi, Husni Zaeem, Ahmad Azam, Ummi Azmira, Alias, Abdul Hafiz, Kesut, Saiful Aizar, Lee, Jun May, Ooi, Dar Vin, Sulaiman, Hetty Ayuni, Tengku Lih, Tengku Alini, Mansor, Marzida, Veerakumaran, Jeyaganesh, Luna, Pastor, Rojas, Eder, Resendiz, Gerardo Esteban Alvarez, Zapata, Darcy Danitza Mari, Aguilar López, Julio Cesar Jesús, Flores, Armando Adolfo Alvarez, Amador, Juan Carlosc Bravo, Avila, Erendira Jocelin Dominguez, Aquino, Laura Patricia González, Rodriguez, Ricardo Lopez, Landa, Mariana Torres, Urias, Emma, Hollmann, Markus, Hulst, Abraham, Kirzner, Osne, Preckel, Benedikt, Koopman-van Gemert, Ankie, Bouwman, Arthur, Buise, Marc, Tolenaar, Noortje, Weber, Eric, de Fretes, Jennifer, Houweling, Peter, Ormskerk, Patricia, Van Bommel, Jasper, Buhre, Wolfgang, Lance, Marcus, Smit-Fun, Valerie, van Zundert, Tom, Baas, Peter, de Boer, Hans Donald, Sprakel, Joost, Elferink-Vonk, Renske, Noordzij, Peter, van Zeggeren, Laura, Brand, Bastiaan, spanjersberg, Rob, ten Bokkel-Andela, Janneke, Numan, Janneke, van Klei, Wilton, van Zaane, Bas, Boer, Christa, van Duivenvoorde, Yoni, Hering, Jens Peter, Zonneveldt, Harry, Campbell, Doug, Hoare, Siobhan, Santa, Sahayam, Allen, Sara Jane, Beavis, Vanessa, Bell, Rachel, Choi, Hyun-min David, Drake, Matthew, Farrell, Helen, Higgie, Kushlin, Holmes, Kerry, Jenkins, Nicole, Kim, Chang Joon, Kim, Steven, Law, Kiew Chai, McAllister, Davina, Park, Karen, Pedersen, Karen, Pfeifer, Leesa, Salmond, Timothy, Steynor, Martin, Tan, Michael, Waymouth, Ellen, Ab Rahman, Ahmad Sufian, Armstrong, John, Dudson, Rosie, Jenkins, Nia, Nilakant, Jayashree, Richard, Seigne, Virdi, Pardeep, Dixon, Liane, Donohue, Roana, Farrow, Mehreen, Kennedy, Ross, Marissa, Henderson, McKellow, Margie, Nicola, Delany, Pascoe, Rebecca, Roberts, Stephen John, Rowell, George, Sumner, Matthew, Templer, Paul, Chandrasekharan, Shardha, Fulton, Graham, Jammer, Ib, Ali, Marlynn, More, Richard, Wilson, Leona, Chang, Yuan Hsuan, Chang, Julia, Fowler, Carolyn, Panckhurst, Jonathan, 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Ikemefuna, Onuora, Elias, Onyeka, Tonia, Ugwu, Innocent, Umeh, Friday, Alagbe-Briggs, Olubusola, Dodiyi-Manuel, Amabra, Echem, Richard, Obasuyi, Bright, Onajin-Obembe, Bisola, Bandeira, Maria Expedito, Martins, Alda, Tomé, Miguel, Martins Costa, Ana Cristina Miranda, Krystopchuk, Andriy, Branco, Teresa, Esteves, Simao, Melo, Marco António, Monte, Júlia, Rua, Fernando, Martins, Isabel, Pinho-Oliveira, Vítor Miguel, Rodrigues, Carla Maria, Cabral, Raquel, Marques, Sofia, Rêgo, Sara, Teixeira Jesus, Joana Sofia, Conceição Marques, Maria, Romao, Cristina, Dias, Sandra, Santos, Ana Margarida, Alves, Maria Joao, Salta, Cristina, Cruz, Salome, Duarte, Célia, Furtado Paiva, António Armando, do Nascimento Cabral, Tiago, Fariae Maia, Dionisio, Correia da Silva, Rui Freitas Mendonça, Langner, Anuschka, Oliveira Resendes, Hernâni, da Conceição Soares, Maria, Abrunhosa, Alexandra, Faria, Filomena, Miranda, Lina, Pereira, Helena, Serra, Sofia, Ionescu, Daniela, Margarit, Simona, Mitre, Calin, Vasian, Horatiu, Manga, Gratiela, Stefan, Andreea, Tomescu, Dana, Filipescu, Daniela, Paunescu, Marilena-Alina, Stefan, Mihai, Stoica, Radu, Gavril, Laura, Pătrăşcanu, Emilia, Ristescu, Irina, Rusu, Daniel, Diaconescu, Ciresica, Iosep, Gabriel Florin, Pulbere, Dorin, Ursu, Irina, Balanescu, Andreea, Grintescu, Ioana, Mirea, Liliana, Rentea, Irina, Vartic, Mihaela, Lupu, Mary-Nicoleta, Stanescu, Dorin, Streanga, Lavinea, Antal, Oana, Hagau, Natalia, Patras, Dumitru, Petrisor, Cristina, Tosa, Flaviu, Tranca, Sebastian, Copotoiu, Sanda Maria, Ungureanu, Liviu Lucian, Harsan, Cristian Remus, Papurica, Marius, Cernea, Daniela Denisa, Dragoescu, Nicoleta Alice, Aflori, Laura, Vaida, Carmen, Ciobotaru, Oana Roxana, Aignatoaie, Mariana, Carp, Cristina Paula, Cobzaru, Isabelle, Mardare, Oana, Purcarin, Bianca, Tutunaru, Valentin, Ionita, Victor, Arustei, Mirela, Codita, Anisoara, Busuioc, Mihai, Chilinciuc, Ion, Ciobanu, Cristina, Belciu, Ioana, Tincu, Eugen, Blaj, Mihaela, Grosu, Ramona–Mihaela, Sandu, Gigel, Bruma, Dana, Corneci, Dan, Dutu, Madalina, Krepil, Adriana, Copaciu, Elena, Dumitrascu, Clementina Oana, Jemna, Ramona, Mihaescu, Florentina, Petre, Raluca, Tudor, Cristina, Ursache, Elena, Kulikov, Alexander, Lubnin, Andrey, Grigoryev, Evgeny, Pugachev, Stanislav, Protsenko, Denis, Tolmasov, Alexander, Hussain, Ayyaz, Ilyina, Yana, Kirov, Mikhail, Roshchina, Anna, Iurin, Aleksandr, Chazova, Elena, Dunay, Artem, Karelov, Alexey, Khvedelidze, Irina, Voldaeva, Olga, Belskiy, Vladislav, Dzhamullaev, Parvin, Grishkowez, Elena, Kretov, Vladimir, Levin, Valeriy, Molkov, Aleksandr, Puzanov, Sergey, Samoilenko, Aleksandr, Tchekulaev, Aleksandr, Tulupova, Valentina, Utkin, Ivan, Allorto, Nikki Leigh, Bishop, David Gray, Builu, Pierre Monji, Cairns, Carel, Dasrath, Ashish, de Wet, Jacques, denHoedt, Marielle, Grey, Ben, Hayes, Morgan Philip, Küsel, Belinda Senta, Shangase, Nomcebo, Wise, Robert, Cacala, Sharon, Farina, Zane, Govindasamy, Vishendran, Kruse, 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Jenna L., Torborg, Alexandra, Visser, Linda, Anderson, Philip, Conradie, Alae, de Swardt, Mathew, de Villiers, Martin, Eikman, Johan, Liebenberg, Riaan, Mouton, Johan, Paton, Abbey, van der Merwe, Louwrence, Wilscott-Davids, Candice, Barrett, Wendy Joan, Bester, Marlet, de Beer, Johan, Geldenhuys, Jacques, Gouws, Hanni, Potgieter, Jan-Hendrik, Strydom, Magdel, Wilberforce-Turton, Edwin, Chetty, Rubendraj R., Chirkut, Subash, Cronje, Larissa, de Vasconcellos, Kim, Dube, Nokukhanya Z., SibusisoGama, N., Green, Garyth M., Green-Thompson, Randolph, Kinoo, Suman Mewa, Kistnasami, Prenolin, Maharaj, Kapil, Moodley, Manogaran S., Mothae, Sibongile J., Naidoo, Ruvashni, Aslam, M., Noorbhai, F., Rughubar, Vivesh, Reddy, Jenendhiran, Singh, Avesh, Skinner, David L., Smith, Murray J., Singh, Bhagwan, Misra, Ravi, Naidoo, Maheshwar, Ramdharee, Pireshin, Selibea, Yvonne, Sewpersad, Selina, Sham, Shailendra, Wessels, Joseph D., Africander, Cucu, Bejia, Tarek, Blakemore, Stephen P., Botes, Marisa, Bunwarie, Bimalshakth, Hernandez, Carlos B., Jeeraz, Mohammud A., Legutko, Dagmara A., Lopez, Acela G., De Meyer, Jenine N., Muzenda, Tanaka, Naidoo, Noel, Patel, Maryam, Pentela, Rao, Junge, Marina, Mansoor, Naj, Rademan, Lana, Scislowski, Pawel, Seedat, Ismail, van den Berg, Bianca, van der Merwe, Doreen, van Wyk, Steyn, Govender, Komalan, Naicker, Darshan, Ramjee, Rajesh, Saley, Mueen, Kuhn, Warren Paul, Matos-Puig, Roel, Moolla, Zaheer, Lisi, Alberto, Perez, Gisela, Valle Beltran, Anna, Lozano, Angels, Delgado Navarro, Carlos, Duca, Alejandro, Pastor Martinez, Ernesto, Ferrando, Carlos, Fuentes, Isabel, García-Pérez, Maria Luisa, Gracia, Estefania, Izquierdo Palomares, Ana, Katime, Antonio, Miñana, Amanda, Incertis, Raul, Romero, Esther, Romero Garcia, Carolina Soledad, Rubio, Concepcion, Socorro Artiles, Tania, Soro, Marina, Valls, Paola, Laguarda, Gisela Alaman, Benavent, Pau, Cuenca, Vicente Chisbert, Cueva, Andreu, Lafuente, Matilde, Parra, Asuncion Marques, Rodrigo, Alejandra 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Denham, Samuel, Griffiths, Ewen, Ip, Peter, Jeyanthan, Somasundaram, Joory, Kavita, Kaur, Satwant, Marriott, Paul, Mitchell, Natalie, Nagaiah, Sukumar, Nilsson, Annette, Parekh, Nilesh, Pope, Martin, Seager, Joseph, Serag, Hosam, Tameem, Alifia, Thomas, Anna, Thunder, Joanne, Torrance, Andrew, Vohra, Ravinder, whitehouse, Arlo, Wong, Tony, Blunt, Mark, Wong, Kate, Giles, Julian, Reed, Isabelle, Weller, Debbie, Bell, Gillian, Birch, Julie, Damant, Rose, Maiden, Jane, Mewies, Clare, Prince, Claire, Radford, Jane, Balain, Birender, Banerjee, Robin, Barnett, Andrew, Burston, Ben, Davies, Kirsty, Edwards, Jayne, Evans, Chris, Ford, David, Gallacher, Pete, Hill, Simon, Jaffray, David, Karlakki, Sudheer, Kelly, Cormac, Kennedy, Julia, Kiely, Nigel, Lewthwaite, Simon, Marquis, Chris, Ockendon, Matthew, Phillips, Stephen, Pickard, Simon, Richardson, James, Roach, Richard, Smith, Tony, Spencer-Jones, Richard, Steele, Niall, Steen, Julie, Van Liefland, Marck, White, Steve, Faulds, Matthew, Harris, Meredyth, Kelly, Carrie, Nicol, Scott, Pearson, Sally Anne, Chukkambotla, Srikanth, Andrew, Alyson, Attrill, Elizabeth, Campbell, Graham, Datson, Amanda, Fouracres, Anna, Graterol, Juan, Graves, Lynne, Hong, Bosun, Ishimaru, Alexander, Karthikeyan, Arvind, King, Helen, Lawson, Tom, Lee, Gregory, Lyons, Saoirse, Macalister Hall, Andrew, Mathoulin, Sophie, Mcintyre, Eilidh, Mclaughlin, Danny, Mulcahy, Kathleen, Ratcliffe, Anna, Robbins, James, Sung, Weilin, Tayo, Adeoluwa, Trembath, Lisa, Venugopal, Suneetha, Walker, Robert, Wigmore, Geoffrey, Boereboom, Catherine, Downes, Charlotte, Humphries, Ryan, Melbourne, Susan, Smith, Coral, Tou, Samson, Ullah, Shafa, Batchelor, Nick, Boxall, Leigh, Broomby, Rupert, Deen, Tariq, Hellewell, Alistair, Helliwell, Laurence, Hutchings, Melanie, Hutchins, David, Keenan, Samantha, Mackie, Donna, Donna, Alison, Smith, Frances, Stone, Lucy, Thorpe, Kevin, Wassall, Richard, Woodgate, Andrew, Baillie, Shelley, Campbell, Tara, James, Sarah, King, Chris, Marques de Araujo, Daniela, Martin, Daniel, Morkane, Clare, Neely, Julia, Rajendram, Rajkumar, Burton, Megan, James, Kathryn, Keevil, Edward, Minik, Orsolya, Morgan, Jenna, Musgrave, Anna, Rajanna, Harish, Roberts, Tracey, Szakmany, Tamas, Adamson, Michael, Jumbe, Sandra, Kendall, Jennie, Muthuswamy, Mohan Babu, Anderson, Charlotte, Cruikshanks, Andrew, Pothuneedi, Sailaja, Walker, Rachel, Wrench, Ian, Zeidan, Lisa, Ardern, Diane, Harris, Benjamin, Hellstrom, Johanna, Martin, Jane, Thomas, Richard, Varsani, Nimu, Wrey Brown, Caroline, Docherty, Philip, Gillies, Michael, McGregor, Euan, Usher, Helen, Craig, Jayne, Smith, Andrew, Ahmad, Tahania, Bodger, Phoebe, Creary, Thais, Everingham, Kirsty, Fowler, Alexander, Hewson, Russ, Ijuo, Eke, Januszewska, Marta, Jones, Timothy, Kantsedikas, Ilya, Lahiri, Sumitra, McLean, Aaron Lawson, Niebrzegowska, Edyta, Phull, Mandeep, Wang, Difei, Wickboldt, Nadine, Baldwin, Jacqueline, Doyle, Donna, Mcmullan, Sean, Oladapo, Michelle, Owen, Thomas, Tripathi, Shiva, Williams, Alexandra, Daniel, Hull, Gregory, Peter, Husain, Tauqeer, Kirk-Bayley, Justin, Mathers, Edward, Montague, Laura, White, Stuart, Avis, Joanne, Cook, Tim, Dali-Kemmery, Lola, Kerslake, Ian, Lambourne, Victoria, Pearson, Annabel, Boyd, Christine, Callaghan, Mark, Lawson, Cathy, McCrossan, Roopa, Nesbitt, Vanessa, O’connor, Laura, Scott, Julia, Sinclair, Rhona, Farid, Nahla, Morgese, Ciro, Bhatia, Kailash, Karmarkar, Swati, Vohra, Akbar, Ahmed, Jamil, Branagan, Graham, Hutton, Monica, Swain, Andrew, Brookes, Jamie, Cornell, Jonathan, Dolan, Rachael, Hulme, Jonathan, Jansen van Vuuren, Amanda, Jowitt, Tom, Kalashetty, Gunasheela, Lloyd, Fran, Patel, Kiran, Sherwood, Nicholas, Brown, Lynne, Chandler, Ben, Deighton, Kerry, Emma, Temlett, Haunch, Kirsty, Cheeseman, Michelle, Dent, Kathy, Garg, Sanjeev, Gray, Carol, Hood, Marion, Jones, Dawn, Juj, Joanne, Mitra, Atideb, Rao, Roshan, Walker, Tara, Al Anizi, Mashel, Cheah, Clarissa, Cheing, Yushio, Coutinho, Francisco, Gondo, Prisca, Hadebe, Bernard, Onie Hove, Mazvangu, khader, Ahamed, Krishnachetty, Bobby, Rhodes, Karen, Sokhi, Jagdish, Baker, Katie-Anne, Bertram, Wendy, Looseley, Alex, Mouton, Ronelle, Arnold, Glenn, Arya, Shobhit, Balfoussia, Danai, Baxter, Linden, Harris, James, Jones, Craig, Knaggs, Alison, Markar, Sheraz, Perera, Anisha, Scott, Alasdair, Shida, Asako, Sirha, Ravneet, Wright, Sally, Frost, Victoria, Gray, Catherine, MacGregor, Mark, Andrews, Emma, Arrandale, Lindsay, Barrett, Stephen, Bidd, Heena, Cifra, Elna, Cooper, Mariese, Dragnea, Dragos, Elna, Cifra, Maclean, Jennifer, Meier, Sonja, Milliken, Donald, Munns, Christopher, Ratanshi, Nadir, Salvana, Abegail, Watson, Anthony, Ali, Hani, Campbell, Gill, Critchley, Rebecca, Hicks, Catherine, Liddle, Alison, Pass, Marc, Ritchie, Charlotte, Thomas, Charlotte, Too, Lingxi, Welsh, Sarah, Gill, Talvinder, Johnson, Joanne, Reed, Joanne, Davis, Edward, Papadopoullos, Sam, Attwood, Clare, Biffen, Andrew, Boulton, Kerenza, Gray, Sophie, Hay, David, Mills, Sarah, Montgomery, Jane, Riddell, Rory, Simpson, James, Bhardwaj, Neeraj, Paul, Elaine, Uwubamwen, Nosakhare, Vohra, Akbar, Berntsen, Emer, Nolan, Tracey, Turner, Angus, Alexander, Maini, Arrich, James, Arumugam, Swarna, Blackwood, Douglas, Boggiano, Victoria, Brown, Robyn, Lam Chan, Yik, Chatterjee, Devnandan, Chhabra, Ashok, Christian, Rachel, Costelloe, Hannah, CoxwellMatthewman, Madeline, Dalton, Emma, Darko, Julia, Davari, Maria, Dave, Tejal, Deacon, Matthew, Deepak, Shantal, Edmond, Holly, Ellis, Jessica, El-Sayed, Ahmed, Eneje, Philip, English, Rose, Ewe, Renee, Foers, William, Franklin, John, Gallego, Laura, Garrett, Emily, Goldberg, Olivia, Goss, Harry, Greaves, Rosanna, Harris, Rudy, Hennings, Charles, Jones, Eleanor, Kamali, Nelson, Kokkinos, Naomi, Lewis, Carys, Lignos, Leda, Malgapo, Evaleen Victoria, Malik, Rizwana, Milne, Andrew, Mulligan, John-Patrick, Nicklin, Philippa, Palipane, Natasha, Parsons, Thomas, Piper, Rebecca, Prakash, Rohan, Ramesh, Byron, Rasip, Sarah, Reading, Jacob, Rela, Mariam, Reyes, Anna, Robert, Stephens, Rooms, Martin, Shah, Karishma, Simons, Henry, Solanki, Shalil, Spowart, Emma, Stevens, Amy, Thomas, Christopher, Waggett, Helena, Yassaee, Arrash, Kennedy, Anthony, Scott, Sara, Somanath, Sameer, Berg, Andrew, Hernandez, Miguel, Nanda, Rajesh, Tank, Ghanshyambhai, Wilson, Natalie, Wilson, Debbie, Al-Soudaine, Yassr, Baldwin, Matthew, Cornish, Julie, Davies, Zoe, Davies, Leigh, Edwards, Marc, Frewer, Natasha, Gallard, Sian, Glasbey, James, Harries, Rhiannon, Hopkins, Luke, Kim, Taeyang, Koompirochana, Vilavan, Lawson, Simon, Lewis, Megan, Makzal, Zaid, Scourfield, Sarah, Ahmad, Yousra, Bates, Sarah, Blackwell, Clare, Bryant, Helen, Coulter, Suzanne, Cruickshank, Ross, Daniel, Sonya, Daubeny, Thomas, Edwards, Mark, Golder, Kim, Hawkins, Lesley, Helen, Bryant, Hinxman, Honor, Levett, Denny, Skinner, Ben, Walsgrove, Joseph, Bradburn, Mike, Dickson, Jane, Constantin, Kathryn, Karen, Markwell, O’Brien, Peter, O’Donohoe, Lynn, Payne, Hannah, Sundayi, Saul, Walker, Elaine, Brooke, Jenny, Cardy, Jon, Humphreys, Sally, Kessack, Laura, Kubitzek, Christiane, Kumar, Suhas, Cotterill, Donna, Hodzovic, Emil, Hosdurga, Gurunath, Miles, Edward, Saunders, Glenn, Campbell, Marta, Chan, Peter, Jemmett, Kim, Raj, Ashok, Naik, Aditi, Ramamoorthy, Rajarajan, Shah, Nimesh, Sylvan, Axel, Blyth, Katharine, Burtenshaw, Andrew, Freeman, David, Johnson, Emily, Lo, Philip, Martin, Terry, Plunkett, Emma, Wollaston, Julie, Allison, Joanna, Carroll, Christine, Craw, Nicholas, Craw, Sarah, Pitt-Kerby, Tressy, Rowland-Axe, Rebecca, Spurdle, Katie, McDonald, Andrew, Simon, Davies, Sinha, Vivek, Smith, Thomas, Banner-Goodspeed, Valerie, Boone, Myles, Campbell, Kathleen, Lu, Fengxin, Scannell, Joseph, Sobol, Julia, Balajonda, Naraida, Clemmons, Karen, Conde, Carlos, Funk, Bonita, Hall, Roger, Hopkins, Thomas, Olaleye, Omowunmi, Omer, Omer, Pender, Michelle, Porto, Angelo, Stevens, Alice, Waweru, Peter, Yeh, Erlinda, Bodansky, Daniella, Evans, Adam, Kleopoulos, Steven, Maril, Robert, Mathney, Edward, Sanchez, Angela, Tinuoye, Elizabeth, Bateman, Brian, Eng, Kristen, Jiang, Ning, Ladha, Karim, Needleman, Joseph, Chen, Lee-lynn, Chen, Lee-lynn, Lane, Rondall, Robinowitz, David, Ghushe, Neil, Irshad, Mariam, Patel, Samir, Takemoto, Steven, Wallace, Art, Mazzeffi, Michael, Rock, Peter, Wallace, Karin, Zhu, Xiaomao, Chua, Pandora, Fleisher, Lee, Mattera, Matthew, Sharar, Rebecca, Thilen, Stephan, Treggiari, Miriam, Morgan, Angela, Sofjan, Iwan, Subramaniam, Kathirvel, Avidan, Michael, Maybrier, Hannah, Muench, Maxwell, Wildes, Troy, and The International Surgical Outcomes Study (ISOS) group
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- 2017
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34. Angiotensin‐converting‐enzyme insertion/deletion polymorphism, ACE activity, and COVID‐19: A rather controversial hypothesis. A case‐control study
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A. Kominakis, Eftychia Polyzogopoulou, Georgios Antonakos, Christos Kroupis, Paraskevi Moutsatsou, Anastasia Antoniadou, Argirios E. Tsantes, Anna Papadopoulou, Sotirios Tsiodras, Vasiliki Papaevangelou, Apostolos Armaganidis, Ioanna Kokkinopoulou, Athina Nikolaidou, Eirini Maratou, Dimitra Dimopoulou, and Paraskevi C. Fragkou
- Subjects
medicine.medical_specialty ,Peptidyl-Dipeptidase A ,Severity of Illness Index ,SARS‐CoV‐2 ,Pathogenesis ,INDEL Mutation ,COVID‐19 ,Polymorphism (computer science) ,Virology ,Internal medicine ,Genotype ,medicine ,Humans ,ACE activity ,Risk factor ,Allele ,Pandemics ,Alleles ,Research Articles ,ACE ,Retrospective Studies ,angiotensin converting enzyme ,Polymorphism, Genetic ,biology ,business.industry ,Case-control study ,COVID-19 ,Angiotensin-converting enzyme ,ACE polymorphism ,Infectious Diseases ,Endocrinology ,Case-Control Studies ,Relative risk ,biology.protein ,business ,Research Article - Abstract
Accumulating data has shown a contribution of the renin‐angiotensin system in COVID‐19 pathogenesis. The role of angiotensin‐converting enzyme (ACE) insertion (I)/deletion (D) polymorphism as a risk factor in developing COVID‐19 disease comes from epidemiological data and is controversially discussed. We conducted a retrospective case‐control study and assessed the impact of ACE I/D genotype in COVID‐19 disease prevalence and severity. In 81 COVID‐19 patients explicitly characterized and 316 controls, recruited during the first wave of COVID‐19 pandemic, ACE I/D genotype, and ACE activity were determined. A generalized linear model was used and Poisson regression analysis estimated the risk ratios (RRs) of alleles and genotypes for disease severity. DD patients had almost 2.0‐fold increased risk (RR: 1.886, confidence limit [CL] 95%: 1.266–2.810, p = 0.0018) of developing a more severe disease when contrasted to ID and II individuals, as did D allele carriers compared to I carriers (RR: 1.372; CL 95%: 1.051–1.791; p = 0.0201). ACE activity (expressed as arbitrary units, AU/L) was lower in patients (3.62 ± 0.26) than in controls (4.65 ± 0.13) (p
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- 2021
35. Elevated biomarkers of endothelial dysfunction/activation at ICU admission are associated with sepsis development
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Vassiliou, Alice G., Mastora, Zafeiria, Orfanos, Stylianos E., Jahaj, Edison, Maniatis, Nikolaos A., Koutsoukou, Antonia, Armaganidis, Apostolos, and Kotanidou, Anastasia
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- 2014
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36. Prognostic value of serum chemerin in critically ill patients with sepsis: a prospective study
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I Karampela, G Christodoulatos, N Vallianou, D Tsilingiris, E Chrysanthopoulou, G Skyllas, G Antonakos, I Marinou, E Vogiatzakis, A Armaganidis, and M Dalamaga
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- 2022
37. Kinetics of serum chemerin in critically ill patients with sepsis: a prospective study
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I Karampela, G Christodoulatos, N Vallianou, D Tsilingiris, E Chrysanthopoulou, G Skyllas, G Antonakos, I Marinou, E Vogiatzakis, A Armaganidis, and M Dalamaga
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- 2022
38. Prognostic value of serum chemerin in critically ill patients with sepsis: a prospective study
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Karampela, I, primary, Christodoulatos, G, additional, Vallianou, N, additional, Tsilingiris, D, additional, Chrysanthopoulou, E, additional, Skyllas, G, additional, Antonakos, G, additional, Marinou, I, additional, Vogiatzakis, E, additional, Armaganidis, A, additional, and Dalamaga, M, additional
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- 2022
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39. Kinetics of serum chemerin in critically ill patients with sepsis: a prospective study
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Karampela, I, primary, Christodoulatos, G, additional, Vallianou, N, additional, Tsilingiris, D, additional, Chrysanthopoulou, E, additional, Skyllas, G, additional, Antonakos, G, additional, Marinou, I, additional, Vogiatzakis, E, additional, Armaganidis, A, additional, and Dalamaga, M, additional
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- 2022
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40. Coronary flow reserve is associated with tissue ischemia and is an additive predictor of intensive care unit mortality to traditional risk scores in septic shock
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Ikonomidis, Ignatios, Makavos, George, Nikitas, Nikitas, Paraskevaidis, Ioannis, Diamantakis, Argyris, Kopterides, Petros, Theodorakopoulou, Maria, Parissis, John, Lekakis, John, Armaganidis, Apostolos, and Dimopoulou, Ioanna
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- 2014
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41. How to select an antifungal agent in critically ill patients
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Dimopoulos, George, Antonopoulou, Anastasia, Armaganidis, Apostolos, and Vincent, Jean-Louis
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- 2013
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42. ESICM LIVES 2016: part three: Milan, Italy. 1–5 October 2016
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Velasquez, T., Mackey, G., Lusk, J., Kyle, U. G., Fontenot, T., Marshall, P., Shekerdemian, L. S., Coss-Bu, J. A., Nishigaki, A., Yatabe, T., Tamura, T., Yamashita, K., Yokoyama, M., Ruiz-Rodriguez, J. C., Encina, B., Belmonte, R., Troncoso, I., Tormos, P., Riveiro, M., Baena, J., Sanchez, A., Bañeras, J., Cordón, J., Duran, N., Ruiz, A., Caballero, J., Nuvials, X., Riera, J., Serra, J., Rutten, A. M. F., van Ieperen, S. N. M., Der Kinderen, E. P. H. M., Van Logten, T., Kovacikova, L., Skrak, P., Zahorec, M., Kyle, U. G., Akcan-Arikan, A., Silva, J. C., Mackey, G., Lusk, J., Goldsworthy, M., Shekerdemian, L. S., Coss-Bu, J. A., Wood, D., Harrison, D., Parslow, R., Davis, P., Pappachan, J., Goodwin, S., Ramnarayan, P., Chernyshuk, S., Yemets, H., Zhovnir, V., Pulitano’, S. M., De Rosa, S., Mancino, A., Villa, G., Tosi, F., Franchi, P., Conti, G., Patel, B., Khine, H., Shah, A., Sung, D., Singer, L., Haghbin, S., Inaloo, S., Serati, Z., Idei, M., Nomura, T., Yamamoto, N., Sakai, Y., Yoshida, T., Matsuda, Y., Yamaguchi, Y., Takaki, S., Yamaguchi, O., Goto, T., Longani, N., Medar, S., Abdel-Aal, I. R., El Adawy, A. S., Mohammed, H. M. E. H., Mohamed, A. N., Parry, S. M., Knight, L. D., Denehy, L., De Morton, N., Baldwin, C. E., Sani, D., Kayambu, G., da Silva, V. Z. M., Phongpagdi, P., Puthucheary, Z. A., Granger, C. L., Rydingsward, J. E., Horkan, C. M., Christopher, K. B., McWilliams, D., Jones, C., Reeves, E., Atkins, G., Snelson, C., Aitken, L. M., Rattray, J., Kenardy, J., Hull, A. M., Ullman, A., Le Brocque, R., Mitchell, M., Davis, C., Macfarlane, B., Azevedo, J. C., Rocha, L. L., De Freitas, F. F. M., Cavalheiro, A. M., Lucinio, N. M., Lobato, M. S., Ebeling, G., Kraegpoeth, A., Laerkner, E., De Brito-Ashurst, I., White, C., Gregory, S., Forni, L. G., Flowers, E., Curtis, A., Wood, C. A., Siu, K., Venkatesan, K., Muhammad, J. B. H., Ng, L., Seet, E., Baptista, N., Escoval, A., Tomas, E., Agrawal, R., Mathew, R., Varma, A., Dima, E., Charitidou, E., Perivolioti, E., Pratikaki, M., Vrettou, C., Giannopoulos, A., Zakynthinos, S., Routsi, C., Atchade, E., Houzé, S., Jean-Baptiste, S., Thabut, G., Genève, C., Tanaka, S., Lortat-Jacob, B., Augustin, P., Desmard, M., Montravers, P., de Molina, F. J. González, Barbadillo, S., Alejandro, R., Álvarez-Lerma, F., Vallés, J., Catalán, R. M., Palencia, E., Jareño, A., Granada, R. M., Ignacio, M. L., Cui, N., Liu, D., Wang, H., Su, L., Qiu, H., Li, R., Jaffal, K., Rouzé, A., Poissy, J., Sendid, B., Nseir, S., Paramythiotou, E., Rizos, M., Frantzeskaki, F., Antoniadou, A., Vourli, S., Zerva, L., Armaganidis, A., Riera, J., Gottlieb, J., Greer, M., Wiesner, O., Martínez, M., Acuña, M., Rello, J., Welte, T., Atchade, E., Mignot, T., Houzé, S., Jean-Baptiste, S., Thabut, G., Lortat-Jacob, B., Tanaka, S., Augustin, P., Desmard, M., Montravers, P., Soussi, S., Dudoignon, E., Ferry, A., Chaussard, M., Benyamina, M., Alanio, A., Touratier, S., Chaouat, M., Lafaurie, M., Mimoun, M., Mebazaa, A., Legrand, M., Sheils, M. A., Patel, C., Mohankumar, L., Akhtar, N., Noriega, S. K. Pacheco, Aldana, N. Navarrete, León, J. L. Ávila, Baquero, J. Durand, Bernal, F. Fernández, Ahmadnia, E., Hadley, J. S., Millar, M., Hall, D., Hewitt, H., Yasuda, H., Sanui, M., Komuro, T., Kawano, S., Andoh, K., Yamamoto, H., Noda, E., Hatakeyama, J., Saitou, N., Okamoto, H., Kobayashi, A., Takei, T., Matsukubo, S., Rotzel, H. B., Lázaro, A. Serrano, Prada, D. Aguillón, Gimillo, M. Rodriguez, Barinas, O. Diaz, Cortes, M. L. Blasco, Franco, J. Ferreres, Roca, J. M. Segura, Carratalá, A., Gonçalves, B., Turon, R., Mendes, A., Miranda, F., Mata, P. J., Cavalcanti, D., Melo, N., Lacerda, P., Kurtz, P., Righy, C., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Romero, J. C. García, Herrera, A. N. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Hualde, J. Barado, Hernández, A. Ansotegui, Irazabal, J. M. Guergué, Spatenkova, V., Bradac, O., Suchomel, P., Urli, T., Lazzeri, E. Heusch, Aspide, R., Zanello, M., Perez-Borrero, L., Garcia-Alvarez, J. M., Arias-Verdu, M. D., Aguilar-Alonso, E., Rivera-Fernandez, R., Mora-Ordoñez, J., De La Fuente-Martos, C., Castillo-Lorente, E., Guerrero-Lopez, F., Lesmes, S. P. Gómez, Rosario, L. E. De la Cruz, Pertuz, E. D. Díaz, Hernández, A. Ansotegui, Romero, J. C. García, Sánchez, M. J. Gómez, Herrera, A. N. García, Ramírez, J. Roldán, Sanz, E. Regidor, Hualde, J. Barado, León, J. P. Tirapu, Navarro-Guillamón, L., Cordovilla-Guardia, S., Iglesias-Santiago, A., Guerrero-López, F., Fernández-Mondéjar, E., Vidal, A., Perez, M., Juez, A., Arias, N., Colino, L., Perez, J. L., Pérez, H., Calpe, P., Alcala, M. A., Robaglia, D., Perez, C., Lan, S. K., Cunha, M. M., Moreira, T., Santos, F., Lafuente, E., Fernandes, M. J., Silva, J. G., Rosario, L. E. de la Cruz, Lesmes, S. P. Gómez, Herrera, A. N. García, Romero, J. C. García, Pertuz, E. D. Díaz, Sánchez, M. J. Gómez, Sanz, E. Regidor, Echeverría, J. G. Armando, Hernández, A. Ansotegui, Hualde, J. Barado, Podlepich, V., Sokolova, E., Alexandrova, E., Lapteva, K., Kurtz, P., Shuinotsuka, C., Rabello, L., Vianna, G., Reis, A., Cairus, C., Salluh, J., Bozza, F., Torres, J. C. Barrios, Araujo, N. J. Fernández, García-Olivares, P., Keough, E., Dalorzo, M., Tang, L. K., De Sousa, I., Díaz, M., Marcos-Zambrano, L. J., Guerrero, J. E., Gomez, S. E. Zamora, Lopez, G. D. Hernandez, Cuellar, A. I. Vazquez, Nieto, O. R. Perez, Gonzalez, J. A. Castanon, Bhasin, D., Rai, S., Singh, H., Gupta, O., Bhattal, M. K., Sampley, S., Sekhri, K., Nandha, R., Aliaga, F. A., Olivares, F., Appiani, F., Farias, P., Alberto, F., Hernández, A., Pons, S., Sonneville, R., Bouadma, L., Neuville, M., Mariotte, E., Radjou, A., Lebut, J., Chemam, S., Voiriot, G., Dilly, M. P., Mourvillier, B., Dorent, R., Nataf, P., Wolff, M., Timsit, J. F., Ediboglu, O., Ataman, S., Ozkarakas, H., Kirakli, C., Vakalos, A., Avramidis, V., Obukhova, O., Kurmukov, I. A., Kashiya, S., Golovnya, E., Baikova, V. N., Ageeva, T., Haritydi, T., Kulaga, E. V., Rios-Toro, J. J., Perez-Borrero, L., Aguilar-Alonso, E., Arias-Verdu, M. D., Garcia-Alvarez, J. M., Lopez-Caler, C., De La Fuente-Martos, C., Rodriguez-Fernandez, S., Sanchez-Orézzoli, M. Gomez, Martin-Gallardo, F., Nikhilesh, J., Joshi, V., Villarreal, E., Ruiz, J., Gordon, M., Quinza, A., Gimenez, J., Piñol, M., Castellanos, A., Ramirez, P., Jeon, Y. D., Jeong, W. Y., Kim, M. H., Jeong, I. Y., Ahn, M. Y., Ahn, J. Y., Han, S. H., Choi, J. Y., Song, Y. G., Kim, J. M., Ku, N. S., Shah, H., Kellner, F., Rezai, F., Mistry, N., Yodice, P., Ovnanian, V., Fless, K., Handler, E., Alejos, R. Martínez, Romeu, J. D. Martí, Antón, D. González, Quinart, A., Martí, A. Torres, Llaurado-Serra, M., Lobo-Civico, A., Ventura-Rosado, A., Piñol-Tena, A., Pi-Guerrero, M., Paños-Espinosa, C., Peralvo-Bernat, M., Marine-Vidal, J., Gonzalez-Engroba, R., Montesinos-Cerro, N., Treso-Geira, M., Valeiras-Valero, A., Martinez-Reyes, L., Sandiumenge, A., Jimenez-Herrera, M. F., Helyar, S., Riozzi, P., Noon, A., Hallows, G., Cotton, H., Keep, J., Hopkins, P. A., Taggu, A., Renuka, S., Sampath, S., Rood, P. J. T., Frenzel, T., Verhage, R., Bonn, M., Pickkers, P., van der Hoeven, J. G., van den Boogaard, M., Corradi, F., Melnyk, L., Moggia, F., Pienovi, R., Adriano, G., Brusasco, C., Mariotti, L., Lattuada, M., Bloomer, M. J., Coombs, M., Ranse, K., Endacott, R., Maertens, B., Blot, K., Blot, S., Amerongen, M. P. van Nieuw, van der Heiden, E. S., Twisk, J. W. R., Girbes, A. R. J., Spijkstra, J. J., Riozzi, P., Helyar, S., Cotton, H., Hallows, G., Noon, A., Bell, C., Peters, K., Feehan, A., Keep, J., Hopkins, P. 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E., GETGAG Working Group, JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group, CAPCRI Study, for the ReVA Research Network and the PROVE Network Investigators, from the FROG ICU Investigators, The WIND study group, Plug Working Group, GETGAG/SEMICYUC, AKI Research Group, St George’s University of London, IPREA Study Group, FINNRESUSCI Study Group, PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre, ENVIN-HELICS Study Group, ARIAM registry of adult cardiac surgery, The Rapid Diagnosis of Infections in the Critically Ill Team, Tokyo Womens Medical University, PLUG working group, PLUG Working Group, On behalf of Okayama Research Investigation Organizing Network (ORION)investigators, PS-ICU Group, Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group, Student Research Committee - Shiraz University of Medical Sciences, ARIAM-ANDALUCIA, The WIND study group, PLUG Working Group, The WIND study group, PLUG Working Group, and Plug working group
- Published
- 2016
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43. Protocol for an international, multicentre, prospective, observational study of nosocomial pneumonia in intensive care units: the PneumoINSPIRE study
- Author
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Christian Brun-Buisson, Matthew Judd, Despoina Koulenti, Jean-Ralph Zahar, Julia Garcia-Diaz, Kostoula Arvaniti, Jan J. De Waele, Biostatistics, Biomathematics, Pharmacoepidemiology, Marcos I. Restrepo, Yuchi Zhang, Christian Putensen, Jason A. Roberts, Bin Du, Maria Deja, Sotirios Tsiodras, Joel M. Dulhunty, Jean-François Timsit, Apostolos Armaganidis, Stijn Blot, Rosa Reina, Jeffrey Lipman, Jordi Rello, Fredrik Sjövall, Pulmonary, and David L. Paterson
- Subjects
medicine.medical_specialty ,business.industry ,Mortality rate ,medicine.disease ,Pneumonia ,Antibiotic resistance ,Intensive care ,Health care ,Epidemiology ,medicine ,Observational study ,business ,Intensive care medicine ,Prospective cohort study - Abstract
Background: Nosocomial pneumonia in the critical care setting is associated with increased morbidity, significant crude mortality rates and high health care costs. Ventilator-associated pneumonia represents about 80% of nosocomial pneumonia cases in intensive care units (ICUs). Wide variance in incidence of nosocomial pneumonia and diagnostic techniques used has been reported, while successful treatment remains complex and a matter of debate. Objective: To describe the epidemiology, diagnostic strategies and treatment modalities for nosocomial pneumonia in contemporary ICU settings across multiple countries around the world. Design, setting and patients: PneumoINSPIRE is a large, multinational, prospective cohort study of adult ICU patients diagnosed with nosocomial pneumonia. Participating ICUs from at least 20 countries will collect data on 10 or more consecutive ICU patients with nosocomial pneumonia. Site-specific information, including hospital policies on antibiotic therapy, will be recorded along with patient-specific data. Variables that will be explored include: aetiology and antimicrobial resistance patterns, treatment-related parameters (including time to initiation of antibiotic therapy, and empirical antibiotic choice, dose and escalation or de-escalation), pneumonia resolution, ICU and hospital mortality, and risk factors for unfavourable outcomes. The concordance of ventilator-associated pneumonia diagnosis with accepted definitions will also be assessed. Results and conclusions: PneumoINSPIRE will provide valuable information on current diagnostic and management practices relating to ICU nosocomial pneumonia, and identify research priorities in the field. Trial registration: ClinicalTrials.gov identifier NCT02793141.
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- 2021
44. Survivin and caspases serum protein levels and survivin variants mRNA expression in sepsis
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Efrossini Briassouli, AM Spanaki, Serafim Nanas, George L. Daikos, Maria Theodorakopoulou, Marina Mantzourani, K. Vardas, T Tavladaki, Eumorfia Kondili, Aikaterini Pistiki, Sotirios Tsiodras, Apostolos Armaganidis, Aikaterini Polonifi, Marianna Miliaraki, Dimitrios Georgopoulos, Panagiotis Briassoulis, George Briassoulis, Stavroula Ilia, and Helen Dimitriou
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Male ,Survivin ,Science ,Serum protein ,Pathogenesis ,Real-Time Polymerase Chain Reaction ,Article ,Sepsis ,Medical research ,Humans ,Medicine ,Prospective Studies ,RNA, Messenger ,Caspase ,Messenger RNA ,Multidisciplinary ,biology ,Caspase 3 ,business.industry ,Middle Aged ,medicine.disease ,Caspase 9 ,Systemic Inflammatory Response Syndrome ,Systemic inflammatory response syndrome ,Real-time polymerase chain reaction ,Apoptosis ,Case-Control Studies ,Caspases ,Cancer research ,biology.protein ,Female ,business ,Biomarkers - Abstract
Sepsis is a dysregulated host response to infection related to devastating outcomes. Recently, interest has been shifted towards apoptotic and antiapoptotic pathobiology. Apoptosis is executed through the activation of caspases regulated by a number of antiapoptotic proteins, such as survivin. The survivin and caspases’ responses to sepsis have not yet been elucidated. This is a multicenter prospective observational study concerning patients with sepsis (n = 107) compared to patients with traumatic systemic inflammatory response syndrome (SIRS) (n = 75) and to healthy controls (n = 89). The expression of survivin was quantified through real-time quantitative polymerase chain reaction for the different survivin splice variants (wild type-WT, ΔEx3, 2B, 3B) in peripheral blood leukocytes. The apoptotic or antiapoptotic tendency was specified by measuring survivin-WT, caspase-3, and -9 serum protein concentrations through enzyme-linked immunosorbent assay. The survivin-WT, -2B, -ΔΕx3 mRNA, survivin protein, and caspases showed an escalated increase in SIRS and sepsis, whereas survivin-3B was repressed in sepsis (p p
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- 2021
45. Phlegmonous Gastritis and Streptoccocal Toxic Shock Syndrome: An Almost Lethal Combination
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Dimopoulos, George, primary, Paramythiotou, Elisabeth, additional, Armaganidis, Apostolos, additional, Mitrakou, Cornelia, additional, Savva, Athinna, additional, and Antoniadou, Anastasia, additional
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- 2022
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46. Interstitial cortisol obtained by microdialysis in mechanically ventilated septic patients: Correlations with total and free serum cortisol
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Vassiliadi, Dimitra Argyro, Ilias, Ioannis, Tzanela, Marinella, Nikitas, Nikitas, Theodorakopoulou, Maria, Kopterides, Petros, Maniatis, Nikolaos, Diamantakis, Argyris, Orfanos, Stylianos E., Perogamvros, Ilias, Armaganidis, Apostolos, Keevil, Brian G., Tsagarakis, Stylianos, and Dimopoulou, Ioanna
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- 2013
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47. Factors Associated with Interruptions of Enteral Nutrition and the Impact on Macro- and Micronutrient Deficits in ICU Patients
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Arezina N. Kasti, Maria Theodorakopoulou, Konstantinos Katsas, Kalliopi D. Synodinou, Maroulla D. Nikolaki, Alice Efstathia Zouridaki, Stylianos Fotiou, Aliki Kapetani, and Apostolos Armaganidis
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antioxidants ,Nutrition and Dietetics ,micronutrients ,caloric deficit ,malnutrition ,interruption of enteral nutrition ,intensive care ,Food Science - Abstract
Background and Aim: Feeding interruptions in critical care patients are often unjustified. We aimed to determine the causes, duration, and frequency of enteral nutrition interruptions (ENIs) and to assess macronutrients and antioxidant deficits according to European Society of Parenteral Enteral Nutrition (ESPEN) guidelines. Methods: We prospectively enrolled Intensive Care Unit (ICU) patients admitted for more than 48 h with an inability to orally eat from April to December 2019. The type of enteral nutrition, the number of calories administered, the time of feeding initiation, the reasons for delaying feeding, and the causes for ENI were recorded. Results: 81 patients were enrolled, with a median duration of ENIs of 5.2 (3.4–7.4) hours/day. Gastric residual volume (GRV) monitoring—a highly controversial practice—was the most common cause of ENI (median duration 3 (2.3–3) hours/day). The mean energy intake was 1037 ± 281 kcal/day, while 60.5% of patients covered less than 65% of the total energy needs (1751 ± 295 kcal/day, according to mean Body Mass Index (BMI)). The median daily protein intake did not exceed 0.43 ± 0.3 gr/kg/day of the actual body weight (BW), whereas ESPEN recommends 1.3 gr/kg/day for adjusted BW (p < 0.001). The average administration of micronutrients and antioxidants (arginine, selenium, zinc, vitamins) was significantly less than the dietary reference intake (p < 0.01). Conclusion: ENIs lead to substantial caloric, protein, and antioxidant deficits.
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- 2023
48. Preclinical pulmonary capillary endothelial dysfunction is present in brain dead subjects
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Glynos, Constantinos, Athanasiou, Chariclea, Kotanidou, Anastasia, Korovesi, Ioanna, Kaziani, Katerina, Livaditi, Olga, Dimopoulou, Ioanna, Maniatis, Nikolaos A., Tsangaris, Iraklis, Roussos, Charis, Armaganidis, Apostolos, and Orfanos, Stylianos E.
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- 2013
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49. Oxidant/Antioxidant Status Is Impaired in Sepsis and Is Related to Anti-Apoptotic, Inflammatory, and Innate Immunity Alterations
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Miliaraki, Marianna Briassoulis, Panagiotis Ilia, Stavroula and Michalakakou, Kalliopi Karakonstantakis, Theodoros Polonifi, Aikaterini Bastaki, Kalliopi Briassouli, Efrossini Vardas, Konstantinos Pistiki, Aikaterini Theodorakopoulou, Maria and Tavladaki, Theonymfi Spanaki, Anna-Maria Kondili, Eumorfia and Dimitriou, Helen Venihaki, Maria Tsiodras, Sotirios and Georgopoulos, Dimitrios Mantzourani, Marina Nanas, Serafeim and Armaganidis, Apostolos Daikos, George L. Papassotiriou, Ioannis and Briassoulis, George
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Oxidative stress is considered pivotal in the pathophysiology of sepsis. Oxidants modulate heat shock proteins (Hsp), interleukins (IL), and cell death pathways, including apoptosis. This multicenter prospective observational study was designed to ascertain whether an oxidant/antioxidant imbalance is an independent sepsis discriminator and mortality predictor in intensive care unit (ICU) patients with sepsis (n = 145), compared to non-infectious critically ill patients (n = 112) and healthy individuals (n = 89). Serum total oxidative status (TOS) and total antioxidant capacity (TAC) were measured by photometric testing. IL-6, -8, -10, -27, Hsp72/90 (ELISA), and selected antioxidant biomolecules (Zeta n, glutathione) were correlated with apoptotic mediators (caspase-3, capsase-9) and the central anti-apoptotic survivin protein (ELISA, real-time PCR). A wide scattering of TOS, TAC, and TOS/TAC in all three groups was demonstrated. Septic patients had an elevated TOS/TAC, compared to non-infectious critically ill patients and healthy individuals (p = 0.001). TOS/TAC was associated with severity scores, procalcitonin, IL-6, -10, -27, IFN-gamma, Hsp72, Hsp90, survivin protein, and survivin isoforms -2B, -Delta Epsilon x3, -WT (p < 0.001). In a propensity probability (age-sex-adjusted) logistic regression model, only sepsis was independently associated with TOS/TAC (Exp(B) 25.4, p < 0.001). The AUC(TOS/TAC) (0.96 (95% CI = 0.93-0.99)) was higher than AUC(TAC) (z = 20, p < 0.001) or AUC(TOS) (z = 3.1, p = 0.002) in distinguishing sepsis. TOS/TAC, TOS, survivin isoforms -WT and -2B, Hsp90, IL-6, survivin protein, and repressed TAC were strong predictors of mortality (p < 0.01). Oxidant/antioxidant status is impaired in septic compared to critically ill patients with trauma or surgery and is related to anti-apoptotic, inflammatory, and innate immunity alterations. The unpredicted TOS/TAC imbalance might be related to undefined phenotypes in patients and healthy individuals.
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- 2022
50. Circulating Chemerin and Its Kinetics May Be a Useful Diagnostic and Prognostic Biomarker in Critically Ill Patients with Sepsis: A Prospective Study
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Karampela, Irene Christodoulatos, Gerasimos Socrates Vallianou, Natalia Tsilingiris, Dimitrios Chrysanthopoulou, Evangelia and Skyllas, George Antonakos, Georgios Marinou, Ioanna and Vogiatzakis, Evaggelos Armaganidis, Apostolos Dalamaga, Maria
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Chemerin, a novel adipokine, is a potent chemoattractant molecule with antimicrobial properties, implicated in immune responses. Our aim was to investigate circulating chemerin and its kinetics, early in sepsis in critically ill patients and its association with severity and prognosis. Serum chemerin was determined in a cohort of 102 critically ill patients with sepsis during the first 48 h from sepsis onset and one week later, and in 102 age- and gender-matched healthy controls. Patients were followed for 28 days and their outcomes were recorded. Circulating chemerin was significantly higher in septic patients at onset compared to controls (342.3 +/- 108.1 vs. 200.8 +/- 40.1 mu g/L, p < 0.001). Chemerin decreased significantly from sepsis onset to one week later (342.3 +/- 108.1 vs. 308.2 +/- 108.5 mu g/L, p < 0.001), but remained higher than in controls. Chemerin was higher in patients presenting with septic shock than those with sepsis (sepsis onset: 403.2 +/- 89.9 vs. 299.7 +/- 99.5 mu g/L, p < 0.001; one week after: 374.9 +/- 95.3 vs. 261.6 +/- 91.9 mu g/L, p < 0.001), and in nonsurvivors than survivors (sepsis onset: 427.2 +/- 96.7 vs. 306.9 +/- 92.1 mu g/L, p < 0.001; one week after: 414.1 +/- 94.5 vs. 264.2 +/- 79.9 mu g/L, p < 0.001). Moreover, patients with septic shock and nonsurvivors, presented a significantly lower absolute and relative decrease in chemerin one week after sepsis onset compared to baseline (p < 0.001). Based on ROC curve analyses, the diagnostic performance of chemerin (AUC 0.78, 95% CI 0.69-0.87) was similar to C-reactive protein (CRP) (AUC 0.78, 95% CI 0.68-0.87) in discriminating sepsis severity. However, increased chemerin at sepsis onset and one week later was an independent predictor of 28-day mortality (sepsis onset: HR 3.58, 95% CI 1.48-8.65, p = 0.005; one week after: HR 10.01, 95% CI 4.32-23.20, p < 0.001). Finally, serum chemerin exhibited significant correlations with the severity scores, white blood cells, lactate, CRP and procalcitonin, as well as with biomarkers of glucose homeostasis, but not with cytokines and soluble urokinase-type plasminogen activator receptor (suPAR). Circulating chemerin is increased early in sepsis and its kinetics may have diagnostic and prognostic value in critically ill patients. Further studies are needed to shed light on the role of chemerin in sepsis.
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- 2022
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