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116 results on '"Arlett, Colin F."'

5. A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

Author

Savitsky, Kinneret, Bar-Shira, Anat, Gilad, Shlomit, Rotman, Galit, Ziv, Yael, Vanagaite, Lina, Tagle, Danilo A., Smith, Sara, Uziel, Tamar, Sfez, Sharon, Ashkenazi, Maya, Pecker, Iris, Frydman, Moshe, Harnik, Reli, Patanjali, Sankhavaram R., Simmons, Andrew, Clines, Gregory A., Sartiel, Adam, Gatti, Richard A., Chessa, Luciana, Sanal, Ozden, Lavin, Martin F., Jaspers, N. G. J., Arlett, Colin F., Miki, Toru, Weissman, Sherman M., Lovett, Michael, Collins, Francis S., and Shiloh, Yosef

Published
1995

9. Neurological symptoms and natural course of xeroderma pigmentosum

Author

Anttinen, Anu, Koulu, Leena, Nikoskelainen, Eeva, Portin, Raija, Kurki, Timo, Erkinjuntti, Matti, Jaspers, Nicolaas G. J., Raams, Anja, Green, Michael H. L., Lehmann, Alan R., Wing, Jonathan F., Arlett, Colin F., and Marttila, Reijo J.

Published
2008

34. Biomonitoring of possible human exposure to environmental genotoxic chemicals: Lessons from a study following the wreck of the oil tankerBraer

Author

Cole, Jane, primary, Beare, David M., additional, Waugh, Alastair P.W., additional, Capulas, Emily, additional, Aldridge, Kay E., additional, Arlett, Colin F., additional, Green, Michael H.L., additional, Crum, Jacqueline E., additional, Cox, Derek, additional, Garner, R. Colin, additional, Dingley, Karen H., additional, Martin, Elizabeth A., additional, Podmore, Karen, additional, Heydon, Robert, additional, and Farmer, Peter B., additional

Published
1997
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39. CORRELATION OF UVC AND UVB CYTOTOXICITY WITH THE INDUCTION OF SPECIFIC PHOTOPRODUCTS IN T-LYMPHOCYTES AND FIBROBLASTS FROM NORMAL HUMAN DONORS

Author

Clingen, Peter H., primary, Arlett, Colin F., additional, Cole, Jane, additional, Waugh, Alastair P. W., additional, Lowe, Jillian E., additional, Harcourt, Susan A., additional, Hermanova, Nadezda, additional, Roza, Len, additional, Mori, Toshio, additional, Nikaido, Osamu, additional, and Green, Michael H. L., additional

Published
1995
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43. Short tandem repeat profiling provides an international reference standard for human cell lines.

Author

Thomson, Jim A., Daly-Burns, Bernadette, Reid, Yvonne A., Dirks, Wilhelm G., Packer, Phil, Toji, Lorraine H., Ohno, Tadao, Tanabe, Hideyuki, Arlett, Colin F., Kelland, Lloyd R., Harrison, Maureen, Virmani, Arvind, Ward, Timothy H., Ayres, Karen L., and Debenham, Paul G.

Subjects
DNA fingerprinting, CELL lines
Abstract

Examines the application of short tandem DNA repeat profiling for the detection of human cell line cross-contamination.

Published
2001

44. Frequencies of hprt– mutations and bcl-2 translocations in circulating human lymphocytes are correlated with United Kingdom sunlight records.

Author

Bentham, Graham, Wolfreys, Alison M., Yafei Liu, Cortopassi, Gino, Green, Michael H. L., Arlett, Colin F., and Cole, Jane

Subjects
LYMPHOCYTES, GENETIC mutation, IMMUNOREGULATION, ULTRAVIOLET radiation
Abstract

Between 1983 and 1995 we have monitored human populations for evidence of exposure to environmental mutagens, taking blood samples to measure hprt– mutant frequency in T cells and more recently bcl-2 t(14:18) translocation frequency in B cells. We have now analysed data from 785 assays on 448 blood samples from 308 normal subjects and find that there is a highly significant statistical correlation between hprt– mutant frequency and the sunlight record for the 3 weeks prior to taking the blood sample. We discuss the weaknesses in retrospective studies of this nature and the possibility of spurious epidemiological correlations that may result. More controlled experiments can be envisaged that would give a firmer basis to the statistical associations observed. hprt– mutations in T cells show little evidence of a UV fingerprint, so that the correlation may be due to immunomodulation rather than mutation. We also find a correlation between the sunlight record and bcl-2 translocation. This translocation is found at a low frequency in the B cells of many normal subjects and is the commonest translocation observed in nonHodgkin's lymphoma. Our results strengthen the case for a link between sunlight and this increasingly common cancer. [ABSTRACT FROM PUBLISHER]

Published
1999
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45. A HUMAN SUBJECT WITH A NEW DEFECT IN REPAIR OF ULTRAVIOLET DAMAGE.

Author

Arlett, Colin F., Lehmann, Alan R., Giannelli, Francesco, and Ramsay, Colin A.

Subjects
*ULTRAVIOLET radiation, *FIBROBLASTS, *SKIN, *XERODERMA pigmentosum, *ALLERGIES, *SURGICAL excision
Abstract

The subject under study (11961) is a child with extreme sun sensitivity. Fibroblasts derived from the child's skin, like those from patients with the disorder xeroderma pigmentosum were hypersensitive to the lethal effects of 254 nm and 310 nm UV-irradiation. Unlike xeroderma pigmentosum cells, however, fibroblasts from our subject were not hypersensitive to the chemical mutagen N-hydroxyacetylaminofluorene but they were hypersensitive to ethylmethanesulfonate. Furthermore, despite the ultra violet light sensitivity, no defects could be detected either in excision or postreplication repair of damaged DNA after UV-irradiation of 11961 cells. This again contrasts with xeroderma pigmentosum cells, which are defective in one or the other of these repair processes. On the basis of these characteristics and the clinical symptoms, we are not at present able to classify this patient as having any of the known sun-sensitive syndromes. [ABSTRACT FROM AUTHOR]

Published
1978
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46. Comparative Human Cellular Radiosensitivity: II. The Survival Following Gamma-irradiation of Unstimulated (G 0 ) T-lymphocytes, T-lymphocyte Lines, Lymphoblastoid Cell Lines and Fibroblasts from Normal Donors, from Ataxia-telangiectasia Patients and from Ataxia-telangiectasia Heterozygotes

Author

Cole, Jane, Arlett, Colin F., Green, Michael H. L., Harcourt, Susan A., Priestley, Anne, Henderson, Leigh, Cole, Helen, James, S. Elizabeth, and Richmond, Frances

Published
1988
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48. Comparative Human Cellular Radiosensitivity: II. The Survival Following Gamma-irradiation of Unstimulated (G0) T-lymphocytes, T-lymphocyte Lines, Lymphoblastoid Cell Lines and Fibroblasts from Normal Donors, from Ataxia-telangiectasia Patients and from Ataxia-telangiectasia Heterozygotes

Author

Cole, Jane, Arlett, Colin F., Green, Michael H.L., Harcourt, Susan A., Priestley, Anne, Henderson, Leigh, Cole, Helen, James, S. Elizabeth, and Richmond, Frances

Abstract

We have measured clonal survival following gamma-irradiation of unstimulated (G0) T-lymphocytes from 35 donors, of 11 T-lymphocyte cell lines, of six lymphoblastoid cell lines, and of nine primary fibroblast strains for which we have G0 T-lymphocyte material from the same donor. Amongst the G0 lymphocytes we have results from nine normal donors, from eight cord bloods, from seven ataxia-telangiectasia (A-T) patients and from nine A-T heterozygotes. Although there is some variation between samples, G0 T-lymphocytes from normal donors appear to be slightly more radioresistant than T-lymphocyte lines, with a more shouldered survival curve. From our limited sample, lymphoblastoid cell lines appear to be slightly more radiosensitive than T-lymphocytes. The overall radiosensitivity of primary fibroblasts appears to be broadly similar to that of G0 T-lymphocytes. In nine instances, five A-Ts and four A-T heterozygotes, both G0 T-lymphocytes and primary fibroblasts from the same donor were tested. In five cases there was closely similar radiosensitivity in the two cell types, but in four cases there was some discrepancy. Further work, especially with normal donors, will be required in order to establish how reliably radiosensitivity in other cell types can be predicted from that of G0 T-lymphocytes. In all cell types the hypersensitivity of A-T cells was confirmed. Furthermore, the marginally greater sensitivity of A-T heterozygotes, when compared as a group with normals, was confirmed with G0 T-lymphocytes. Our results also suggest a slightly increased radiosensitivity in G0 T-lymphocytes from some, but not all, cord blood samples.

Published
1988
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49. Lack of discernible effect of diagnostic ultrasound on the chromosomes of cord blood lymphocytes exposed in utero

Author

Henderson, Leigh M., Aghamohammadi, S. Zeinab, Arlett, Colin F., and Cole, Robin J.

Abstract

The levels of either sister chromatid exchanges or chromosome breakage (as assayed by the frequency of micronuclei) in cord blood lymphocytes from a total of 62 babies were analysed. The exposure of these babies to ultrasound during gestation was determined retrospectively from medical records and the data reclassified accordingly. No correlation was seen between the levels of chromosome breakage, as measured by these two end-points, and exposure to ultrasound.

Published
1986
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50. A Gamma-Ray-Resistant Derivative of an Ataxia Telangiectasia Cell Line Obtained Following DNA-Mediated Gene Transfer

Author

Green, Michael H. L., Lowe, Jill E., Arlett, Colin F., Harcourt, Susan A., Burke, Julian F., James, Michael R., Lehmann, Alan R., and Povey, Susan M.

Abstract

Genomic DNA from normal human or mouse cells was transfected together with the selectable marker gpt into the simian virus 40-transformed ataxia telangiectasia fibroblast line, AT5BIVA. From a series of experiments involving over 400000 clones selected for the gpt marker, one unambiguously radiation-resistant clone (clone 67) was recovered following selection with repeated cycles of gamma irradiation. The normal level of radiation resistance of clone 67 has been maintained for at least 11 months in the absence of further selection by radiation. The resistant clone contains one copy of the gpt gene. Its DNA synthesis following gamma-irradiation is inhibited to an extent intermediate between that of ataxia telangiectasia and normal cells. Three out of four thioguanine-resistant derivatives of clone 67 have either lost or do not express the gpt sequence and show almost the same sensitivity to gamma irradiation as the original AT5BIVA line. This suggests that the radiation resistance of clone 67 may be linked to the gpt sequence and may have arisen as a consequence of the transfection, rather than as the result of an independent mutation to radiation resistance.

Published
1987
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