23 results on '"Arihara F"'
Search Results
2. Phase II clinical trial of second-line weekly paclitaxel plus trastuzumab for patients with HER2-positive metastatic gastric cancer
- Author
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Horita, Y., primary, Nishino, M., additional, Sugimoto, S., additional, Kida, A., additional, Mizukami, A., additional, Yano, M., additional, Arihara, F., additional, Matsuda, K., additional, Matsuda, M., additional, and Sakai, A., additional
- Published
- 2017
- Full Text
- View/download PDF
3. 687P - Phase II clinical trial of second-line weekly paclitaxel plus trastuzumab for patients with HER2-positive metastatic gastric cancer
- Author
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Horita, Y., Nishino, M., Sugimoto, S., Kida, A., Mizukami, A., Yano, M., Arihara, F., Matsuda, K., Matsuda, M., and Sakai, A.
- Published
- 2017
- Full Text
- View/download PDF
4. Relationship Between HER2 Expression and AFP Production in Gastric Cancer
- Author
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Horita, Y., primary, Arihara, F., additional, Hirai, S., additional, Shimatani, A., additional, Matsuda, K., additional, Matsuda, M., additional, Sakai, A., additional, Uchiyama, A., additional, Ishizawa, S., additional, and Noda, Y., additional
- Published
- 2013
- Full Text
- View/download PDF
5. Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization
- Author
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Nakamoto, Y, primary, Mizukoshi, E, additional, Kitahara, M, additional, Arihara, F, additional, Sakai, Y, additional, Kakinoki, K, additional, Fujita, Y, additional, Marukawa, Y, additional, Arai, K, additional, Yamashita, T, additional, Mukaida, N, additional, Matsushima, K, additional, Matsui, O, additional, and Kaneko, S, additional
- Published
- 2010
- Full Text
- View/download PDF
6. O1–001RELATIONSHIP BETWEEN HER2 EXPRESSION AND AFP PRODUCTION IN GASTRIC CANCER.
- Author
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Horita, Y., Arihara, F., Hirai, S., Shimatani, A., Matsuda, K., Matsuda, M., Sakai, A., Uchiyama, A., Ishizawa, S., and Noda, Y.
- Subjects
- *
HER2 gene , *GENE expression , *GASTROINTESTINAL cancer , *INTERNAL medicine , *ALPHA fetoproteins , *GASTROINTESTINAL cancer treatment , *PATIENTS - Published
- 2013
- Full Text
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7. Frequency of CD45RO(+) subset in CD4(+)CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma.
- Author
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Takata Y, Nakamoto Y, Nakada A, Terashima T, Arihara F, Kitahara M, Kakinoki K, Arai K, Yamashita T, Sakai Y, Mizukoshi E, and Kaneko S
- Published
- 2011
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8. Bile duct MALT lymphoma diagnosed with direct cholangioscopy: a case report.
- Author
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Sakashita M, Matsuda K, Omizo T, Orita N, Arihara F, Matsuda M, Ogawa K, Okumura H, Nakanishi Y, and Sakai A
- Subjects
- Female, Humans, Aged, 80 and over, Bile Ducts pathology, Rituximab therapeutic use, Catheterization, Lymphoma, B-Cell, Marginal Zone diagnosis, Lymphoma, B-Cell, Marginal Zone surgery, Lymphoma, B-Cell, Marginal Zone drug therapy
- Abstract
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) extremely rarely arise in extrahepatic biliary tract. Here, we report a case of bile duct MALT lymphoma diagnosed with direct cholangioscopy. The patient was an 80-year-old female with history of esophageal cancer, and had been occasionally treated with balloon dilatation for anastomotic stricture. She was referred to our hospital for treatment of choledocholithiasis. Since transesophageal endoscope insertion was impossible, stone extraction by transjejunal approach was performed. When gastroduodenoscope was directly inserted to the bile duct (direct cholangioscopy), accidentally two flat lesions with development of large atypical vessels in hilar region were noted. Biopsy revealed diffuse infiltration of CD20 positive small- to medium-sized atypical lymphocytes. A diagnosis of bile duct MALT lymphoma was made. The patient underwent eight courses of chemotherapy with rituximab alone, with no evident complications. Although biliary tract MALT lymphoma is rare, advances in cholangioscopy may promote encounter with such lesions. Accumulation of endoscopic figures of biliary tract MALT lymphoma is required., (© 2022. Japanese Society of Gastroenterology.)
- Published
- 2022
- Full Text
- View/download PDF
9. Biliary stones or ulcers at the choledochojejunal anastomotic site involving the jejunal mucosa at stent removal may be recurrent factors in patients with benign choledochojejunal anastomotic stenosis undergoing endoscopic biliary stenting using fully covered self-expandable metal stents.
- Author
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Kida A, Shirota Y, Arihara F, Asai J, Matsuda K, Kakinoki K, Matsuda M, Sakai A, Terada M, and Urabe T
- Subjects
- Cholangiopancreatography, Endoscopic Retrograde adverse effects, Constriction, Pathologic etiology, Constriction, Pathologic surgery, Device Removal adverse effects, Humans, Mucous Membrane, Plastics, Retrospective Studies, Stents adverse effects, Treatment Outcome, Ulcer complications, Cholestasis etiology, Gallstones etiology, Self Expandable Metallic Stents
- Abstract
Background: Temporary fully covered self-expandable metal stent (FCSEMS) placement is performed for benign choledochojejunal anastomotic stenosis (bCJS). However, recurrence may develop after stricture resolution. We investigated endoscopic biliary stenting using FCSEMS for bCJS., Methods: Sixteen bCJS patients with FCSEMS placement were retrospectively analyzed. FCSEMS was removed endoscopically after 2 months. Technical success, stricture resolution, recurrence, and adverse events were evaluated., Results: The technical success rate for FCSEMS placement was 94% (15/16). Biliary stones were detected and extracted in four patients. FCSEMS removal was successfully performed on 14 patients, excluding one with stent migration. At FCSEMS removal, stricture resolution was noted in 14 patients; however, four had anastomotic ulcers. The median follow-up was 319 days. Three patients with a history of repeated plastic stent placement had no recurrence. Four out of 15 patients (27%) had recurrence, and three had no recurrence after additional interventions. Biliary stones before first FCSEMS placement (P = .003) or anastomotic ulcers at FCSEMS removal (P = .018) were associated with recurrence., Conclusions: Although FCSEMS placement was useful for stricture resolution, recurrence was detected in patients with biliary stones before first FCSEMS placement or anastomotic ulcers at FCSEMS removal. Anastomotic ulcers are a risk factor for recurrence and only detected by endoscopy., (© 2022 Japanese Society of Hepato-Biliary-Pancreatic Surgery.)
- Published
- 2022
- Full Text
- View/download PDF
10. Long-term outcomes after endoscopic retrograde pancreatic drainage for symptomatic pancreaticojejunal anastomotic stenosis.
- Author
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Kida A, Shirota Y, Kawane T, Omura H, Kumai T, Yano M, Arihara F, Hodo Y, Matsuda K, Ogawa K, Matsuda M, Sakai A, Terada M, and Wakabayashi T
- Subjects
- Aged, Aged, 80 and over, Cholangiopancreatography, Endoscopic Retrograde methods, Drainage methods, Endosonography methods, Female, Humans, Male, Middle Aged, Pancreaticojejunostomy methods, Retrospective Studies, Stents, Treatment Outcome, Ultrasonography, Interventional methods, Constriction, Pathologic pathology, Pancreas pathology
- Abstract
There is limited evidence supporting the usefulness of endoscopic retrograde pancreatic drainage (ERPD) for symptomatic pancreaticojejunal anastomotic stenosis (sPJS). We examined the usefulness of ERPD for sPJS. We conducted a retrospective analysis of 10 benign sPJS patients. A forward-viewing endoscope was used in all sessions. Following items were evaluated: technical success, adverse events, and clinical outcome of ERPD. The technical success rate was 100% (10/10) in initial ERPD; 9 patients had a pancreatic stent (no-internal-flap: n = 4, internal-flap: n = 5). The median follow-up was 920 days. Four patients developed recurrence. Among them, 3 had a stent with no-internal-flap in initial ERPD, the stent migrated in 3 at recurrence, and a stent was not placed in 1 patient in initial ERPD. Four follow-up interventions were performed. No recurrence was observed in 6 patients. None of the stents migrated (no-internal-flap: n = 1, internal-flap: n = 5) and no stents were replaced due to stent failure. Stenting with no-internal-flap was associated with recurrence (p = 0.042). Mild adverse events developed in 14.3% (2/14). In conclusions, ERPD was performed safely with high technical success. Recurrence was common after stenting with no-internal-flap. Long-term stenting did not result in stent failure.Clinical trial register and their clinical registration number: Nos. 58-115 and R2-9.
- Published
- 2021
- Full Text
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11. [A case of pancreatic actinomycosis diagnosed by EUS-FNA].
- Author
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Hayashi K, Kawane T, Ito A, Yano M, Arihara F, Matsuda K, Ogawa K, Matsuda M, and Sakai A
- Subjects
- Endoscopic Ultrasound-Guided Fine Needle Aspiration, Endosonography, Humans, Male, Middle Aged, Pancreatic Ducts, Tomography, X-Ray Computed, Actinomycosis diagnostic imaging, Actinomycosis drug therapy, Pancreatic Neoplasms
- Abstract
A 60-year-old male patient had alcoholic chronic pancreatitis. Three months prior, he had undergone an exchange of pancreatic duct stents. In December 201X-1, magnetic resonance imaging and computed tomography (CT) scan results showed a caput pancreatic mass and common bile duct dilatation. We considered that it was because of chronic pancreatitis and decided to follow up by imaging studies. Further, in March 201X, a CT scan result revealed worsening of the mass and bile duct dilation. We assessed the mass by endoscopic ultrasound and fine-needle aspiration. Histological findings revealed to an interstitial tissue infiltrated by several neutrophils and plasma cells and abscess-forming inflammation like sulfur granule. The mass was improved by antibiotic administration for 6 months.
- Published
- 2021
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12. Usefulness of endoscopic metal stent placement for malignant afferent loop obstruction.
- Author
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Kida A, Kido H, Matsuo T, Mizukami A, Yano M, Arihara F, Matsuda K, Ogawa K, Matsuda M, and Sakai A
- Subjects
- Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Retrospective Studies, Anastomosis, Roux-en-Y methods, Anastomosis, Surgical methods, Endoscopy methods, Gastroenterostomy methods, Stents standards
- Abstract
Background: Malignant afferent loop obstruction (mALO) can cause cholangitis, pancreatitis, and perforation due to blind loop dilatation. However, peritoneal dissemination, lymph node metastasis, and recurrence of the tumor are the main causes of mALO, and most cases are in the advanced stage with thoracicoabdominal fluid retention, for which surgery and percutaneous transhepatic treatment are challenging. At our hospital, endoscopic metal stent placement (EMSP) has been applied for such mALO. We retrospectively investigated the usefulness of EMSP for mALO., Methods: We conducted a retrospective analysis of 11 mALO patients with EMSP between January 2008 and December 2018. The following items were evaluated: the characteristics of patients, technical success and adverse events of EMSP, clinical efficacy, and outcome after EMSP., Results: The surgical procedures and reconstruction methods were distal gastrectomy with Billroth II reconstruction for 3 patients, pancreaticoduodenectomy with modified-Child reconstruction for 7, choledochojejunostomy with Roux-en-Y reconstruction for 1. The cause of mALO was peritoneal dissemination for 6 patients, local recurrence for 3, lymph node metastasis for 1, and afferent loop invasion for 1. EMSP was attempted in 13 sessions for 11 patients, and successful in 12 of 13 sessions. There were no adverse events. The clinical efficacy was high in successful EMSP. The median survival time after EMSP was 118 days. Ten patients died of primary disease and one patient died of uncontrollable cholangitis after the failure of EMSP. mALO recurred and EMSP was repeated for 2 of 10 patients who died of primary disease., Conclusions: The success rate of EMSP for mALO was high in patients with poor general conditions due to advanced-stage malignant tumors and it was able to be safely performed, suggesting its high clinical efficacy. The incidence of mALO recurrence after EMSP was low.
- Published
- 2020
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13. Successful biliary self-expandable metallic stenting using an ultra-slim endoscope for cholangitis caused by pancreatic cancer.
- Author
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Kida A, Matsuda K, Yano M, Arihara F, Ogawa K, Matsuda M, and Sakai A
- Subjects
- Aged, 80 and over, Cholangitis diagnostic imaging, Contrast Media, Duodenal Ulcer surgery, Equipment Design, Gastrectomy, Humans, Male, Neoplasm Invasiveness, Cholangitis etiology, Cholangitis surgery, Endoscopes, Pancreatic Neoplasms complications, Self Expandable Metallic Stents
- Abstract
Highlight Kida and colleagues described their method for successfully performing biliary self-expandable metallic stenting with the through-the-scope technique using an ultra-slim endoscope for malignant biliary obstruction with duodenal stenosis. This procedure may be useful in cases of duodenal stenosis in which it is difficult to reach the major duodenal papilla., (© 2019 Japanese Society of Hepato-Biliary-Pancreatic Surgery.)
- Published
- 2020
- Full Text
- View/download PDF
14. Phase II clinical trial of second-line weekly paclitaxel plus trastuzumab for patients with HER2-positive metastatic gastric cancer.
- Author
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Horita Y, Nishino M, Sugimoto S, Kida A, Mizukami A, Yano M, Arihara F, Matsuda K, Matsuda M, and Sakai A
- Subjects
- Aged, Aged, 80 and over, Antineoplastic Combined Chemotherapy Protocols adverse effects, Drug Administration Schedule, Female, Humans, Immunohistochemistry, Infusions, Intravenous, Male, Middle Aged, Neoplasm Metastasis, Paclitaxel administration & dosage, Paclitaxel adverse effects, Stomach Neoplasms pathology, Trastuzumab administration & dosage, Trastuzumab adverse effects, Antineoplastic Combined Chemotherapy Protocols administration & dosage, Receptor, ErbB-2 metabolism, Stomach Neoplasms drug therapy, Stomach Neoplasms enzymology
- Abstract
Background: Combination therapy with fluorouracil, platinum, and trastuzumab (Tmab) is the first-line treatment for human epidermal growth factor receptor 2 (HER2)-positive gastric cancer, and there is currently no established second-line therapy. We evaluated the efficacy and safety of weekly paclitaxel plus Tmab as second-line chemotherapy for HER2-positive gastric cancer patients., Patients and Methods: Eligible patients were older than or equal to 20 years, had histologically confirmed gastric adenocarcinoma that was HER2 positive (immunohistochemistry 3+ or immunohistochemistry 2+ and fluorescence in-situ hybridization positive or dual color in-situ hybridization positive), and had been treated previously with chemotherapy (pretreated or not with Tmab). Patients received weekly paclitaxel plus Tmab as the second-line chemotherapy. The primary endpoint was the overall response rate (ORR; threshold ORR=20% and expected ORR=35%)., Results: Twenty-eight patients were enrolled. ORR was 21.4%. The median progression-free survival (PFS) was 4.6 months. The median overall survival (OS) was 9.6 months. No significant differences were observed in ORR, PFS, or OS between the Tmab beyond progression (TBP) group (n=20) and the non-TBP group (n=8). However, in the TBP group, a therapeutic effect was associated with the duration of PFS in the first-line Tmab treatment [≥6 months PFS in the first-line Tmab treatment (n=10) vs. <6 months (n=10); ORR: 40 and 10%, P=0.303, PFS: 6.2 and 2.8 months, P=0.005, OS: 15.8 and 6.5 months, P=0.006, respectively]., Conclusion: Weekly paclitaxel plus Tmab was not superior as second-line chemotherapy for HER2-positive gastric cancer patients, but may be effective for patients who showed better responses to Tmab-combined chemotherapy in the first-line treatment.
- Published
- 2019
- Full Text
- View/download PDF
15. Gastric adenocarcinoma of the fundic gland (chief cell-predominant type): A review of endoscopic and clinicopathological features.
- Author
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Miyazawa M, Matsuda M, Yano M, Hara Y, Arihara F, Horita Y, Matsuda K, Sakai A, and Noda Y
- Subjects
- Biomarkers, Tumor, Biopsy, Diagnosis, Differential, Gastric Fundus cytology, Gastric Fundus surgery, Humans, Immunohistochemistry, Laparoscopy methods, Narrow Band Imaging methods, Neoplasm Recurrence, Local, Pepsinogen A immunology, Polyps diagnosis, Practice Guidelines as Topic, Stomach Neoplasms surgery, Adenocarcinoma diagnosis, Adenocarcinoma pathology, Chief Cells, Gastric pathology, Gastric Fundus pathology, Gastroscopy methods, Stomach Neoplasms diagnosis, Stomach Neoplasms pathology
- Abstract
Gastric adenocarcinoma of the fundic gland (chief cell-predominant type, GA-FG-CCP) is a rare variant of well-differentiated adenocarcinoma, and has been proposed to be a novel disease entity. GA-FG-CCP originates from the gastric mucosa of the fundic gland region without chronic gastritis or intestinal metaplasia. The majority of GA-FG-CCPs exhibit either a submucosal tumor-like superficial elevated shape or a flat shape on macroscopic examination. Narrow-band imaging with endoscopic magnification may reveal a regular or an irregular microvascular pattern, depending on the degree of tumor exposure to the mucosal surface. Pathological analysis of GA-FG-CCPs is characterized by a high frequency of submucosal invasion, rare occurrences of lymphatic and venous invasion, and low-grade malignancy. Detection of diffuse positivity for pepsinogen-I by immunohistochemistry is specific for GA-FG-CCP. Careful endoscopic examination and detailed pathological evaluation are essential for early and accurate diagnosis of GA-FG-CCP. Nearly all GA-FG-CCPs are treated by endoscopic resection due to their small tumor size and low risk of recurrence or metastasis., Competing Interests: Conflict-of-interest statement: Authors declare no Conflict of Interests for this article.
- Published
- 2016
- Full Text
- View/download PDF
16. Electroincision for hypopharyngoesophageal stricture caused by Plummer-Vinson syndrome.
- Author
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Nishitani M, Matsuda M, Arihara F, Sakai A, and Noda Y
- Subjects
- Aged, Constriction, Pathologic surgery, Female, Humans, Electrosurgery methods, Esophageal Stenosis surgery, Hypopharynx surgery, Pharyngeal Diseases surgery, Plummer-Vinson Syndrome surgery
- Published
- 2016
- Full Text
- View/download PDF
17. Gastric adenocarcinoma of fundic gland type: Five cases treated with endoscopic resection.
- Author
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Miyazawa M, Matsuda M, Yano M, Hara Y, Arihara F, Horita Y, Matsuda K, Sakai A, and Noda Y
- Subjects
- Adenocarcinoma chemistry, Adenocarcinoma pathology, Aged, Biomarkers, Tumor analysis, Biopsy, Female, Gastric Fundus chemistry, Gastric Fundus pathology, Humans, Immunohistochemistry, Male, Narrow Band Imaging, Neoplasm Staging, Stomach Neoplasms chemistry, Stomach Neoplasms pathology, Treatment Outcome, Adenocarcinoma surgery, Gastrectomy methods, Gastric Fundus surgery, Gastroscopy methods, Stomach Neoplasms surgery
- Abstract
Recently, a new disease entity termed gastric adenocarcinoma of fundic gland type (GA-FG) was proposed. We treated five cases of GA-FG with endoscopic submucosal dissection. All tumors were small and located in the upper third of the stomach. Four tumors were macroscopically identified as 0-IIa and one was identified as 0-IIb. Narrow-band imaging with magnifying endoscopy showed an irregular microvascular pattern in 2 cases and a regular microvascular pattern in the remainder. All tumors arose from the deep layer of the lamina propria mucosae and showed submucosal invasion. Lymphatic invasion was seen only in one case, while no venous invasion was recognized. All tumors were positive for pepsinogen-I and MUC6 by immunohistochemistry. None showed p53 overexpression, and the labeling index of Ki-67 was low in all cases. All cases have been free from recurrence or metastasis. Herein, we discussed the clinicopathological features of GA-FG in comparison with past reports.
- Published
- 2015
- Full Text
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18. Increase in CD14+HLA-DR -/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis.
- Author
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Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, and Kaneko S
- Subjects
- Aged, Carcinoma, Hepatocellular pathology, Carcinoma, Hepatocellular surgery, Catheter Ablation, Cell Count, Cytokines blood, Cytokines immunology, Disease Progression, Female, Flow Cytometry statistics & numerical data, HLA-DR Antigens immunology, HLA-DR Antigens metabolism, Humans, Interleukin-10 blood, Interleukin-10 immunology, Interleukin-13 blood, Interleukin-13 immunology, Kaplan-Meier Estimate, Lipopolysaccharide Receptors immunology, Lipopolysaccharide Receptors metabolism, Liver Neoplasms pathology, Liver Neoplasms surgery, Male, Multivariate Analysis, Myeloid Cells metabolism, Myeloid Cells pathology, Neoplasm Recurrence, Local, Prognosis, Proportional Hazards Models, T-Lymphocytes, Regulatory immunology, T-Lymphocytes, Regulatory metabolism, T-Lymphocytes, Regulatory pathology, Vascular Endothelial Growth Factor A blood, Vascular Endothelial Growth Factor A immunology, Carcinoma, Hepatocellular immunology, Liver Neoplasms immunology, Myeloid Cells immunology
- Abstract
Myeloid-derived suppressor cells (MDSCs) are known as key immune regulators in various human malignancies, and it is reported that CD14(+)HLA-DR(-/low) MDSCs are increased in hepatocellular carcinoma (HCC) patients. However, the host factors that regulate the frequency and the effect on the prognosis of HCC patients are still unclear. We investigated these issues and clarified the relationships between a feature of MDSCs and host factors in HCC patients. We examined the frequency of MDSCs in 123 HCC patients, 30 chronic liver disease patients without HCC, and 13 healthy controls by flow cytometric analysis. The relationships between the clinical features and the frequency of MDSCs were analyzed. In 33 patients who received curative radiofrequency ablation (RFA) therapy, we examined the impact of MDSCs on HCC recurrence. The frequency of MDSCs in HCC patients was significantly increased. It was correlated with tumor progression, but not with the degree of liver fibrosis and inflammation. In terms of serum cytokines, the concentrations of IL-10, IL-13, and vascular endothelial growth factor were significantly correlated with the frequency of MDSCs. In HCC patients who received curative RFA therapy, the frequency of MDSCs after treatment showed various changes and was inversely correlated with recurrence-free survival time. The frequency of MDSCs is correlated with tumor progression, and this frequency after RFA is inversely correlated with the prognosis of HCC patients. Patients with a high frequency of MDSCs after RFA should be closely followed and the inhibition of MDSCs may improve the prognosis of patients.
- Published
- 2013
- Full Text
- View/download PDF
19. Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma.
- Author
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Mizukoshi E, Yamashita T, Arai K, Sunagozaka H, Ueda T, Arihara F, Kagaya T, Yamashita T, Fushimi K, and Kaneko S
- Subjects
- Aged, Carcinoma, Hepatocellular immunology, Carcinoma, Hepatocellular pathology, Female, Humans, Kaplan-Meier Estimate, Liver Neoplasms immunology, Liver Neoplasms pathology, Male, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local, Phenotype, Prognosis, Survival Rate, T-Lymphocytes pathology, Antigens, Neoplasm metabolism, Carcinoma, Hepatocellular surgery, Catheter Ablation, Histocompatibility Antigens Class II metabolism, Liver Neoplasms surgery, T-Lymphocytes immunology
- Abstract
Unlabelled: Radiofrequency ablation (RFA) is one of the treatments for hepatocellular carcinoma (HCC) and is known to enhance host immune response. However, the epitopes to which enhanced immune responses occur, the impact on patient prognosis, and the functions and phenotype of T cells induced are still unclear. To address these issues, we analyzed immune responses before and after RFA in 69 HCC patients using 11 tumor-associated antigen (TAA)-derived peptides that we identified to be appropriate to analyze HCC-specific immune responses. The immune responses were analyzed using enzyme-linked immunospot (ELISPOT) assay and tetramer assays using peripheral blood mononuclear cells. An increase in the number of TAA-specific T cells detected by interferon-γ ELISPOT assays occurred in 62.3% of patients after RFA. The antigens and their epitope to which enhanced T cell responses occur were diverse, and some of them were newly induced. The number of TAA-specific T cells after RFA was associated with the prevention of HCC recurrence, and it was clarified to be predictive of HCC recurrence after RFA by univariate and multivariate analyses. The number of TAA-specific T cells after RFA was inversely correlated with the frequency of CD14+ HLA-DR(-/low) myeloid-derived suppressor cells (MDSCs). The modification of T cell phenotype was observed after RFA. The number of TAA-specific T cells at 24 weeks after RFA was decreased., Conclusion: Although RFA can enhance various TAA-specific T cell responses and the T cells induced contribute to the HCC recurrence-free survival of patients, besides immunosuppression by MDSCs, the memory phenotype and lifetime of TAA-specific T cells are not sufficient to prevent HCC recurrence completely. Additional treatments by vaccine or immunomodulatory drugs might be useful to improve the immunological effect of RFA., (Copyright © 2012 American Association for the Study of Liver Diseases.)
- Published
- 2013
- Full Text
- View/download PDF
20. [Anal canal basaloid carcinoma with vaginal invasion which was recurrence-free for 5 years postoperatively].
- Author
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Sawada S, Hori M, Watanabe S, Arihara F, Kimura N, Shirai S, and Naoe S
- Subjects
- Aged, Female, Humans, Neoplasm Invasiveness, Recurrence, Anal Canal, Anus Neoplasms pathology, Anus Neoplasms surgery, Carcinoma, Basosquamous pathology, Carcinoma, Basosquamous surgery, Vagina pathology
- Abstract
We performed abdomino-perineal resection of the rectum and partial resection of a vagina in a 78-year-old woman on a diagnosis of anal canal basaloid carcinoma with vaginal invasion. We did not perform specific adjuvant therapy pre- or postoperatively, but no recurrence appeared for 5 years. Anal canal basaloid carcinoma is a comparatively rare disorder, and the prognosis is relatively good. It seemed that determination of the indication of postoperative adjuvant therapy will require the accumulation of future further cases and enough appearance with operative methods in the treatment of anal canal basaloid carcinoma.
- Published
- 2011
21. Usefulness of ultrasonography combined with conventional physical examination in mass screening for breast cancer: a retrospective study of Yamanashi Health Care Center results from 1989 to 1994.
- Author
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Okamoto H, Ogawara T, Arihara F, Kobayashi K, Inoue S, Nagahori K, Yamamoto M, Sekikawa T, and Matsumoto Y
- Subjects
- Adult, Aged, Aged, 80 and over, Breast Neoplasms diagnosis, Breast Neoplasms epidemiology, Evaluation Studies as Topic, Female, Humans, Japan epidemiology, Middle Aged, Retrospective Studies, Sensitivity and Specificity, Ultrasonography, Breast Neoplasms diagnostic imaging, Mass Screening methods, Palpation
- Abstract
We retrospectively analyzed the records for 34,474 women who participated in mass screening for breast cancer by physical examination with or without ultrasonography (US) at Yamanashi Health Care Center between April, 1989 and March, 1994 to evaluate the usefulness of US in mass screening. In one group (15,935 women) conventional physical examination with inspection and palpation alone had been performed, and in another (18,539 women) both conventional physical and US examinations were performed. Breast cancer was detected in 27 of the women (0.08% of the total group screened), 22 of whom were in the group examined by US; moreover, 16 of these 22 women had early breast cancer, which was a non-palpable tumor in 13. Half of the 22 women were examinees under the age of 50 years. Of the 22 tumors detected in the groups examined by US, 16 (73%) were early breast cancer. The overall detection of early breast cancer (0.09%) in the US group was significantly higher than that (0.01%) in the group examined by conventional methods (P < 0.05). Of the tumors detected in the US group, 59.1% were non-palpable. These results suggest that early and non-palpable breast cancer can be detected using US, and the incidence of detection of such tumors in women under the age 50 years is increased in mass screening including US examination. This examination is effective in mass screening for breast cancer, especially for early and non-palpable breast cancer tumors.
- Published
- 1996
- Full Text
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22. [A case of carcinosarcoma of the esophagus].
- Author
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Maeda Y, Sekikawa T, Noguchi A, Arihara F, Ogawara T, Honda M, Mogaki M, Sugahara K, Oyama T, and Suda K
- Subjects
- Aged, Diagnosis, Differential, Esophagoplasty, Humans, Male, Carcinosarcoma pathology, Carcinosarcoma surgery, Esophageal Neoplasms pathology, Esophageal Neoplasms surgery
- Published
- 1989
23. [Analysis of human mitochondrial DNA in hepatocellular carcinomas].
- Author
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Nagahori K, Yamamoto M, Matsuda M, Itakura J, Iizuka H, Arihara F, and Sugahara K
- Subjects
- Aged, Female, Humans, Male, Middle Aged, Mutation, Carcinoma, Hepatocellular genetics, DNA, Mitochondrial analysis, DNA, Neoplasm analysis, Liver Neoplasms genetics
- Abstract
Based on the following 3 points: 1) tumor proliferation is energy-dependent, 2) mitochondrial energy-production system is dominant for cell growth, and 3) liver mitochondria (mt) possess their own DNA and RNA synthesizing some of their own proteins including respiratory enzymes such as cytochrome oxidases, a possible relationship between mutations of mt-DNA and clinical status of cell proliferation was examined in 10 HCC patients who underwent liver resection. Mt-DNA at the cancerous and the noncancerous portions of 1g resected liver specimens were separated from the nuclear DNA, and then digested with Hinf I endonuclease. DNA filters were made of the digested mt-DNA fragments on the agarose and polyacrylamide gel. The filters were hybridized with a nick-translated 32P-labeled DNA fragments. In two cases, abnormal mt-DNA were detected. In the first case, the tumor was the massive type and grew rapidly invading the bile duct. One restriction fragment of 3.0 Kb of the cancerous and non cancerous portion became larger by 60 bp. In the second case, regarded as metachronous multicentric HCC, the second largest band of the 3.4 Kb fragment of the cancerous portion showed a wider range but not of the noncancerous portion. The former change may indicate polymorphism but the latter indicates an occurrence of the mutation of mt-DNA. Further studies are required, including examinations on the rest of mitochondrial fragments.
- Published
- 1988
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