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149 results on '"Ariey, Frederic"'

1. Plasmodium ovale spp dhfr mutations associated with reduced susceptibility to pyrimethamine in sub-Saharan Africa: a retrospective genetic epidemiology and functional study

Author

Abou-Bacar, Ahmed, Agnamey, Patrice, Ait-Ammar, Nawel, Angoulvant, Adela, Argy, Nicolas, Azjenberg, Daniel, Basmaciyan, Louise, Bastien, Patrick, Belaz, Sorya, Belkadi, Ghania, Bellanger, Anne-Pauline, Bemba, Dieudonné, Berry, Antoine, Botterel, François, Bouden, Vincent, Bougnoux, Marie-Elisabeth, Bouzayene, Azza, Bret, Laurent, Bretagne, Stéphane, Brumpt, Caren, Buret, Bernadette, Caraux-Paz, Pauline, Cheruiyot, Agnes, Chlilek, Alexandre, Clauser, Sylvain, Cojean, Sandrine, Cuisenier, Bernadette, Dahane, Naima, Dannaoui, Eric, Dard, Céline, Dardé, Marie-Laure, de Gentile, Ludovic, Debourgogne, Anne, Dechavanne, Célia, Delaunay, Pascal, Delaval, Anne, Deleplancque, Anne-Sophie, Desoubeaux, Guillaume, Desuremain, Nathalie, Develoux, Michel, Djènontin, Armel, Dossou, Yannelle, Durand, Rémy, Durieux, Marie-Fleur, Dutoit, Emmanuel, Eloy, Odile, Fenneteau, Odile, Fievet, Nadine, Gargala, Gilles, Garnaud, Cécile, Gay-Andrieu, Françoise, Godineau, Nadine, Gravet, Alain, Guennouni, Nadia, Guinard, Jérôme, Hamane, Samia, Huguenin, Antoine, Jumah, Jacqueline, L'Ollivier, Coralie, Landraud, Luce, Larréché, Sébastien, Lavergne, Rose-Anne, Le Govic, Yohann, Lohmann, Caroline, Machouart, Marie-Claire, Marteau, Anthony, Massougbodji, Achille, Mazars, Edith, Mechain, Matthieu, Mendes Moreira, Ana, Merat, Célia, Millon, Laurence, Mombo-Ngoma, Ghyslain, Morelle, Christelle, Morio, Florent, Mwakio, Edwin, Nabias, René, Nourrisson, Céline, Opot, Benjamin, Okhot, Raphael, Patoz, Pierre, Penn, Pascal, Perraud-Cateau, Estelle, Pihet, Marc, Pilo, Jean-Etienne, Pistone, Thierry, Poilane, Isabelle, Pomares, Christelle, Pons, Denis, Pougnet, Laurence, Pull, Lauren, Quinio, Dorothée, Raffenot, Didier, Rapp, Christophe, Receveur, Marie-Catherine, Roosen, Gabrielle, Sarrasin, Véronique, Sasso, Milene, Savini, Hélène, Senghor, Yaye, Silva, Muriel, Simon, Fabrice, Siriez, Jean-Yves, Sossou, Darius, Thellier, Marc, Thouvenin, Maxime, Toubas, Dominique, Tournus, Cécile, Touroult-Jupin, Pauline, Veletzky, Luzia, Vianou, Bertin, Zaffaroullah, Rizwana, Zoleko-Manego, Rella, Joste, Valentin, Coppée, Romain, Bailly, Justine, Rakotoarivony, Yann, Toko Tchokoteu, Francine Ghislaine, Achache, Shany, Pradines, Bruno, Cottrell, Gilles, Ariey, Frédéric, Khim, Nimol, Popovici, Jean, Mita, Toshihiro, Groger, Mirjam, Ramharter, Michael, Egbo, Timothy, Juma, Dennis W, Akala, Hoseah, Houzé, Sandrine, and Clain, Jérôme

Published
2024
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2. Evolution and spread of Plasmodium falciparum mutations associated with resistance to sulfadoxine–pyrimethamine in central Africa: a cross-sectional study

Author

Guémas, Emilie, Coppée, Romain, Ménard, Sandie, du Manoir, Milena, Nsango, Sandrine, Makaba Mvumbi, Dieudonné, Nakoune, Emmanuel, Eboumbou Moukoko, Carole Else, Bouyou Akotet, Marielle Karine, Mirabeau, Tatfeng Youtchou, Manguin, Sylvie, Malekita Yobi, Doudou, Akiana, Jean, Kouna, Lady Charlène, Mawili Mboumba, Denise Patricia, Voumbo-Matoumona, Dominique Fatima, Otam, Alliance-Laure, Rubbo, Pierre-Alain, Lombart, Jean-Pierre, Kwanai, Elisabeth, Cohen, Olivia, Iriart, Xavier, Ayong, Lawrence, Lekana-Douki, Jean Bernard, Ariey, Frédéric, and Berry, Antoine

Published
2023
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3. Highly rearranged mitochondrial genome in Nycteria parasites (Haemosporidia) from bats

Author

Karadjian, Gregory, Hassanin, Alexandre, Saintpierre, Benjamin, Gembu Tungaluna, Guy-Crispin, Ariey, Frederic, Ayala, Francisco J, Landau, Irene, and Duval, Linda

Subjects
Biological Sciences, Evolutionary Biology, Genetics, Rare Diseases, Vector-Borne Diseases, Infectious Diseases, Biotechnology, Human Genome, Malaria, Infection, Good Health and Well Being, Animals, Cambodia, Chiroptera, Democratic Republic of the Congo, Genome, Mitochondrial, Genome, Protozoan, Haemosporida, High-Throughput Nucleotide Sequencing, Mitochondria, Mitochondrial Proteins, Phylogeny, Protozoan Proteins, cytochrome b, evolution, phylogeny, Nycteris
Abstract

Haemosporidia parasites have mostly and abundantly been described using mitochondrial genes, and in particular cytochrome b (cytb). Failure to amplify the mitochondrial cytb gene of Nycteria parasites isolated from Nycteridae bats has been recently reported. Bats are hosts to a diverse and profuse array of Haemosporidia parasites that remain largely unstudied. There is a need to obtain more molecular data from chiropteran parasites. Such data would help to better understand the evolutionary history of Haemosporidia, which notably include the Plasmodium parasites, malaria's agents. We use next-generation sequencing to obtain the complete mitochondrial genome of Nycteria parasites from African Nycteris grandis (Nycteridae) and Rhinolophus alcyone (Rhinolophidae) and Asian Megaderma spasma (Megadermatidae). We report four complete mitochondrial genomes, including two rearranged mitochondrial genomes within Haemosporidia. Our results open outlooks into potentially undiscovered Haemosporidian diversity.

Published
2016

7. A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: a phenotype–genotype association study

Author

Witkowski, Benoit, Duru, Valentine, Khim, Nimol, Ross, Leila S, Saintpierre, Benjamin, Beghain, Johann, Chy, Sophy, Kim, Saorin, Ke, Sopheakvatey, Kloeung, Nimol, Eam, Rotha, Khean, Chanra, Ken, Malen, Loch, Kaknika, Bouillon, Anthony, Domergue, Anais, Ma, Laurence, Bouchier, Christiane, Leang, Rithea, Huy, Rekol, Nuel, Grégory, Barale, Jean-Christophe, Legrand, Eric, Ringwald, Pascal, Fidock, David A, Mercereau-Puijalon, Odile, Ariey, Frédéric, and Ménard, Didier

Published
2017
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11. Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

Author

Takala-Harrison, Shannon, Jacob, Christopher G., Arze, Cesar, Cummings, Michael P., Silva, Joana C., Dondorp, Arjen M., Fukuda, Mark M., Hien, Tran Tinh, Mayxay, Mayfong, Noedl, Harald, Nosten, Francois, Kyaw, Myat P., Nhien, Nguyen Thanh Thuy, Imwong, Mallika, Bethell, Delia, Se, Youry, Lon, Chanthap, Tyner, Stuart D., Saunders, David L., Ariey, Frederic, Mercereau-Puijalon, Odile, Menard, Didier, Newton, Paul N., Khanthavong, Maniphone, Hongvanthong, Bouasy, Starzengruber, Peter, Fuehrer, Hans-Peter, Swoboda, Paul, Khan, Wasif A., Phyo, Aung Pyae, Nyunt, Myaing M., Nyunt, Myat H., Brown, Tyler S., Adams, Matthew, Pepin, Christopher S., Bailey, Jason, Tan, John C., Ferdig, Michael T., Clark, Taane G., Miotto, Olivo, MacInnis, Bronwyn, Kwiatkowski, Dominic P., White, Nicholas J., Ringwald, Pascal, and Plowe, Christopher V.

Published
2015

13. Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

Author

Takala-Harrison, Shannon, Clark, Taane G., Jacob, Christopher G., Cummings, Michael P., Miotto, Olivo, Dondorp, Arjen M., Fukuda, Mark M., Nosten, Francois, Noedl, Harald, Imwong, Mallika, Bethell, Delia, Se, Youry, Lon, Chanthap, Tyner, Stuart D., Saunders, David L., Socheat, Duong, Ariey, Frederic, Phyo, Aung Pyae, Starzengruber, Peter, Fuehrer, Hans-Peter, Swoboda, Paul, Stepniewska, Kasia, Flegg, Jennifer, Arze, Cesar, Cerqueira, Gustavo C., Silva, Joana C., Ricklefs, Stacy M., Porcella, Stephen F., Stephens, Robert M., Adams, Matthew, Kenefic, Leo J., Campino, Susana, Auburn, Sarah, Maclnnis, Bronwyn, Kwiatkowski, Dominic P., Su, Xin-zhuan, White, Nicholas J., Ringwald, Pascal, and Plowe, Christopher V.

Published
2013

14. Induction of multidrug tolerance in Plasmodium falciparum by extended Artemisinin pressure

Author

Menard, Sandie, Haddou, Tanila Ben, Ramadani, Arba Pramundita, Ariey, Frederic, Iriart, Xavier, Beghain, Johann, Bouchier, Christiane, Witkowski, Benoit, Berry, Antoine, Mercereau-Puijalon, Odile, and Benoit-Vical, Francoise

Subjects
Antimalarials -- Health aspects -- Research, Drug resistance, Malaria, Plasmodium falciparum, Health
Abstract

During the past decade, increased commitment and investments in malaria control have markedly reduced malaria-related illness and death in many malaria-endemic areas (1). This progress is threatened by emergence of [...]

Published
2015
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18. Disseminated mucocutaneous leishmaniasis in a traveller with idiopathic CD4 lymphocytopenia.

Author

Thizy, Guillaume, Caumes, Eric, Molher, Joffrey, Ariey, Frederic, Lortholary, Olivier, Buffet, Pierre, and Melenotte, Cléa

Subjects
LEISHMANIASIS, CD4 antigen, CUTANEOUS leishmaniasis, NEGLECTED diseases, LYMPHOPENIA, VISCERAL leishmaniasis
Abstract

This article discusses a case of disseminated cutaneous leishmaniasis (DCL) in a 48-year-old man with idiopathic CD4 lymphocytopenia. The man had been living in Dakar, Senegal, for 20 years and had traveled to over 80 countries. After hiking in the Amazonian forest of Bolivia, he developed numerous insect bites that progressed to ulceration. He received treatment with meglumine antimoniate, but the lesions reappeared. He was later diagnosed with Leishmania braziliensis and treated with liposomal amphotericin B, which resulted in complete healing. The article provides information on the causes, treatments, and outcomes of cutaneous leishmaniasis. [Extracted from the article]

Published
2023
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23. Artemisinin resistance in Plasmodium falciparum malaria

Author

Dondorp, Arjen M., Nosten, Francois, Yi, Porvuth, Das, Debashish, Phyo, Aung Phae, Tarning, Joel, Lwin, Khin Maung, Ariey, Frederic, Hanpithakpong, Warunee, Lee, Sue J., Ringwald, Pascal, Silamut, Kamolrat, Imwong, Mallika, chotivanich, Kesinee, Lim, Pharath, Herdman, Trent, An, Sen Sam, Yeung, Shunmay, Singhasivanon, Pratap, Day, Nicholas, P.J., Lindegardh, Niklas, Socheat, Duong, and White, Nicholas J.

Subjects
Drug resistance -- Research, Malaria -- Drug therapy, Mefloquine -- Dosage and administration, Antimalarials -- Health aspects, Drug therapy, Combination
Abstract

A study was conducted to ascertain the efficacy of artemisinin -based combination therapies as a main treatment for Plasmodium falciparum malaria following reports of declined efficacy of this drug along the Thai-Cambodian border. Results revealed that P. falciparum manifests reduced susceptibility in vivo to artesunate in western Cambodia compared to northwestern Thailand and urgent measures should be taken to address the problem.

Published
2009

24. CTX-M [beta]-lactamases in Escherichia coli from Community-acquired urinary tract infections, Cambodia

Author

Ruppe, Etienne, Hem, Sopheak, Lath, Sovannarith, Gautier, Valerie, Ariey, Frederic, Sarthou, Jean-Louis, Monchy, Didier, and Arlet, and Guillaume

Subjects
Beta lactamases -- Health aspects, Water quality -- Health aspects, Developing countries -- Health aspects, Amoxicillin -- Research, Amoxicillin -- Health aspects, Urinary tract infections -- Research, Urinary tract infections -- Health aspects
Abstract

Escherichia coli is the bacterium most frequently isolated in community- and hospital-acquired urinary tract infections (CA-UTIs and HA-UTIs, respectively). Despite possessing the gene encoding cephalosporinase, ampC (1), wild strains of [...]

Published
2009

25. Molecular surveillance for multidrug-resistant Plasmodium falciparum, Cambodia

Author

Shah, Naman K., Alker, Alisa P., Sem, Rithy, Susanti, Agustina Ika, Muth, Sinuon, Maguire, Jason D., Duong, Socheat, Ariey, Frederic, Meshnick, Steven R., and Wongsrichanalai, Chansuda

Subjects
Mefloquine -- Dosage and administration, Mefloquine -- Research, Plasmodium falciparum -- Health aspects, Plasmodium falciparum -- Genetic aspects, Plasmodium falciparum -- Research, Malaria -- Risk factors, Malaria -- Diagnosis, Malaria -- Research, Genes -- Research
Abstract

We conducted surveillance for multidrug-resistant P/asmodium falciparum in Cambodia during 2004-2006 by assessing molecular changes in pfmdr1. The high prevalence of isolates with multiple pfmdr1 copies found in western Cambodia [...]

Published
2008

27. Clonal Expansion of Artemisinin-Resistant Plasmodium Falciparum in Uganda is Associated with Substandard Treatment Practices

Author

Awor, Phyllis, primary, Khim, Nimol, additional, Coppée, Romain, additional, Rondepierre, Laurine, additional, Roesch, Camille, additional, Khean, Chanra, additional, Kul, Chanvong, additional, Eam, Rotha, additional, Lorn, Thornleaksmey, additional, Athieno, Proscovia, additional, Kimera, Joseph, additional, Clain, Jérôme, additional, Ringwald, Pascal, additional, Signorell, Aita, additional, Lengeler, Christian, additional, Burri, Christian, additional, Ariey, Frederic, additional, Hetzel, Manuel W., additional, and Witkowski, Benoit, additional

Published
2021
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30. Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate-Amodiaquine in Cambodia

Author

Mairet-Khedim, Melissa, primary, Leang, Rithea, additional, Marmai, Camille, additional, Khim, Nimol, additional, Kim, Saorin, additional, Ke, Sopheakvatey, additional, Kauy, Chhayleang, additional, Kloeung, Nimol, additional, Eam, Rotha, additional, Chy, Sophy, additional, Izac, Brigitte, additional, Mey Bouth, Denis, additional, Dorina Bustos, Maria, additional, Ringwald, Pascal, additional, Ariey, Frederic, additional, and Witkowski, Benoit, additional

Published
2020
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31. Letters to the editors

Author

Vijaykadga, Saowanit, Rojanawatsiriwej, Chaiporn, Ariey, Frederic, Meshnick, Steven R., and Wongsrichanalai, Chansuda

Published
2006

32. Plasmodium knowlesi infection in humans, Cambodia, 2007-2010

Author

Khim, Nimol, Siv, Sovannaroth, Kim, Saorin, Mueller, Tara, Fleischmann, Erna, Singh, Balbir, Divis, Paul Cliff Simon, Steenkeste, Nicolas, Duval, Linda, Bouchier, Christiane, Duong, Socheat, Ariey, Frederic, and Menard, Didier

Subjects
Malaria -- Risk factors -- Diagnosis -- Care and treatment -- Research, Plasmodium falciparum -- Health aspects -- Research, Polymerase chain reaction -- Usage, Health
Abstract

In Cambodia, malaria ranks among the leading causes of illness and death. Mostly affecting the ≅ 3 million persons (23% of Cambodia's population) who live near forested areas, malaria remains [...]

Published
2011
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33. Clinical and In Vitro Resistance of Plasmodium falciparum to Artesunate-Amodiaquine in Cambodia.

Author

Mairet-Khedim, Melissa, Leang, Rithea, Marmai, Camille, Khim, Nimol, Kim, Saorin, Ke, Sopheakvatey, Kauy, Chhayleang, Kloeung, Nimol, Eam, Rotha, Chy, Sophy, Izac, Brigitte, Bouth, Denis Mey, Bustos, Maria Dorina, Ringwald, Pascal, Ariey, Frederic, and Witkowski, Benoit

Subjects
DRUG therapy for malaria, DRUG efficacy, BIOMARKERS, COMBINATION drug therapy, CLINICAL trials, SEQUENCE analysis, CONFIDENCE intervals, GENETIC mutation, ORAL drug administration, AMODIAQUINE, PRIMAQUINE, POLYMERASE chain reaction, DRUG resistance in microorganisms, LONGITUDINAL method, THERAPEUTICS
Abstract

Background Artesunate-amodiaquine is a potential therapy for uncomplicated malaria in Cambodia. Methods Between September 2016 and January 2017, artesunate-amodiaquine efficacy and safety were evaluated in a prospective, open-label, single-arm observational study at health centers in Mondulkiri, Pursat, and Siem Reap Provinces, Cambodia. Adults and children with microscopically confirmed Plasmodium falciparum malaria received oral artesunate-amodiaquine once daily for 3 days plus single-dose primaquine, with follow-up on days 7, 14, 21, and 28. The primary outcome was day-28 polymerase chain reaction (PCR)-adjusted adequate clinical and parasitological response (ACPR). An amodiaquine parasite survival assay (AQSA) was developed and applied to whole genome sequencing results to evaluate potential amodiaquine resistance molecular markers. Results In 63 patients, day-28 PCR-adjusted ACPR was 81.0% (95% confidence interval [CI], 68.9–88.7). Day 3 parasite positivity rate was 44.4% (28/63; 95% CI, 31.9–57.5). All 63 isolates had the K13 (C580Y) marker for artemisinin resistance; 79.4% (50/63) had Pfpm2 amplification. The AQSA resistance phenotype (≥45% parasite survival) was expressed in 36.5% (23/63) of isolates and was significantly associated with treatment failure (P = .0020). Pfmdr1 mutant haplotypes were N86/184F/D1246, and Pfcrt was CVIET or CVIDT at positions 72–76. Additional Pfcrt mutations were not associated with amodiaquine resistance, but the G353V mutant allele was associated with ACPR compared to Pfmdr1 haplotypes harboring F1068L or S784L/R945P mutations (P  =  .030 and P  = .0004, respectively). Conclusions For uncomplicated falciparum malaria in Cambodia, artesunate-amodiaquine had inadequate efficacy owing to amodiaquine-resistant P. falciparum. Amodiaquine resistance was not associated with previously identified molecular markers. [ABSTRACT FROM AUTHOR]

Published
2021
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34. Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests

Author

Gamboa Dionicia, Echeverry Diego F, Djalle Djibrine, Cunningham Jane, Bell David, Barnwell John, Ariey Frederic, Albertini Audrey, Abdullah Salim, Chen Nanhua, Gatton Michelle, Pelecanos Anita, Ho Mei-Fong, Baker Joanne, Hii Jeffery, Kyaw Myat, Luchavez Jennifer, Membi Christopher, Menard Didier, Murillo Claribel, Nhem Sina, Ogutu Bernhards, Onyor Pamela, Oyibo Wellington, Wang Shan, McCarthy James, and Cheng Qin

Subjects
Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background Accurate diagnosis is essential for prompt and appropriate treatment of malaria. While rapid diagnostic tests (RDTs) offer great potential to improve malaria diagnosis, the sensitivity of RDTs has been reported to be highly variable. One possible factor contributing to variable test performance is the diversity of parasite antigens. This is of particular concern for Plasmodium falciparum histidine-rich protein 2 (PfHRP2)-detecting RDTs since PfHRP2 has been reported to be highly variable in isolates of the Asia-Pacific region. Methods The pfhrp2 exon 2 fragment from 458 isolates of P. falciparum collected from 38 countries was amplified and sequenced. For a subset of 80 isolates, the exon 2 fragment of histidine-rich protein 3 (pfhrp3) was also amplified and sequenced. DNA sequence and statistical analysis of the variation observed in these genes was conducted. The potential impact of the pfhrp2 variation on RDT detection rates was examined by analysing the relationship between sequence characteristics of this gene and the results of the WHO product testing of malaria RDTs: Round 1 (2008), for 34 PfHRP2-detecting RDTs. Results Sequence analysis revealed extensive variations in the number and arrangement of various repeats encoded by the genes in parasite populations world-wide. However, no statistically robust correlation between gene structure and RDT detection rate for P. falciparum parasites at 200 parasites per microlitre was identified. Conclusions The results suggest that despite extreme sequence variation, diversity of PfHRP2 does not appear to be a major cause of RDT sensitivity variation.

Published
2010
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35. Molecular assays for antimalarial drug resistance surveillance:A target product profile

Author

Nsanzabana, Christian, Ariey, Frederic, Beck, Hans Peter, Ding, Xavier C., Kamau, Edwin, Krishna, Sanjeev, Legrand, Eric, Lucchi, Naomi, Miotto, Olivo, Nag, Sidsel, Noedl, Harald, Roper, Cally, Rosenthal, Philip J., Schallig, Henk D.F.H., Taylor, Steve M., Volkman, Sarah K., Gonzalez, Iveth J., Nsanzabana, Christian, Ariey, Frederic, Beck, Hans Peter, Ding, Xavier C., Kamau, Edwin, Krishna, Sanjeev, Legrand, Eric, Lucchi, Naomi, Miotto, Olivo, Nag, Sidsel, Noedl, Harald, Roper, Cally, Rosenthal, Philip J., Schallig, Henk D.F.H., Taylor, Steve M., Volkman, Sarah K., and Gonzalez, Iveth J.

Abstract

Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance following treatment with artemisinin derivatives has now spread in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination therapies are expected to be available in the near future. There is a need to strengthen surveillance systems for early detection and response to the antimalarial drug resistance threat. Current surveillance is mainly done through therapeutic efficacy studies; however these studies are complex and both time- and resource-intensive. For multiple common antimalarials, parasite drug resistance has been correlated with specific genetic mutations, and the molecular markers associated with antimalarial drug resistance offer a simple and powerful tool to monitor the emergence and spread of resistant parasites. Different techniques to analyse molecular markers associated with antimalarial drug resistance are available, each with advantages and disadvantages. However, procedures are not adequately harmonized to facilitate comparisons between sites. Here we describe the target product profiles for tests to analyse molecular markers associated with antimalarial drug resistance, discuss how use of current techniques can be standardised, and identify the requirements for an ideal product that would allow malaria endemic countries to provide useful spatial and temporal information on the spread of resistance.

Published
2018

36. Molecular assays for antimalarial drug resistance surveillance: A target product profile

Author

Nsanzabana, Christian, primary, Ariey, Frederic, additional, Beck, Hans-Peter, additional, Ding, Xavier C., additional, Kamau, Edwin, additional, Krishna, Sanjeev, additional, Legrand, Eric, additional, Lucchi, Naomi, additional, Miotto, Olivo, additional, Nag, Sidsel, additional, Noedl, Harald, additional, Roper, Cally, additional, Rosenthal, Philip J., additional, Schallig, Henk D. F. H., additional, Taylor, Steve M., additional, Volkman, Sarah K., additional, and Gonzalez, Iveth J., additional

Published
2018
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37. Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum

Author

Bopp, Selina, primary, Magistrado, Pamela, additional, Wong, Wesley, additional, Schaffner, Stephen F., additional, Mukherjee, Angana, additional, Lim, Pharath, additional, Dhorda, Mehul, additional, Amaratunga, Chanaki, additional, Woodrow, Charles J., additional, Ashley, Elizabeth A., additional, White, Nicholas J., additional, Dondorp, Arjen M., additional, Fairhurst, Rick M., additional, Ariey, Frederic, additional, Menard, Didier, additional, Wirth, Dyann F., additional, and Volkman, Sarah K., additional

Published
2018
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39. A Worldwide Map ofPlasmodium falciparumK13-Propeller Polymorphisms

Author

Ménard, Didier, primary, Khim, Nimol, additional, Beghain, Johann, additional, Adegnika, Ayola A., additional, Shafiul-Alam, Mohammad, additional, Amodu, Olukemi, additional, Rahim-Awab, Ghulam, additional, Barnadas, Céline, additional, Berry, Antoine, additional, Boum, Yap, additional, Bustos, Maria D., additional, Cao, Jun, additional, Chen, Jun-Hu, additional, Collet, Louis, additional, Cui, Liwang, additional, Thakur, Garib-Das, additional, Dieye, Alioune, additional, Djallé, Djibrine, additional, Dorkenoo, Monique A., additional, Eboumbou-Moukoko, Carole E., additional, Espino, Fe-Esperanza-Caridad J., additional, Fandeur, Thierry, additional, Ferreira-da-Cruz, Maria-Fatima, additional, Fola, Abebe A., additional, Fuehrer, Hans-Peter, additional, Hassan, Abdillahi M., additional, Herrera, Socrates, additional, Hongvanthong, Bouasy, additional, Houzé, Sandrine, additional, Ibrahim, Maman L., additional, Jahirul-Karim, Mohammad, additional, Jiang, Lubin, additional, Kano, Shigeyuki, additional, Ali-Khan, Wasif, additional, Khanthavong, Maniphone, additional, Kremsner, Peter G., additional, Lacerda, Marcus, additional, Leang, Rithea, additional, Leelawong, Mindy, additional, Li, Mei, additional, Lin, Khin, additional, Mazarati, Jean-Baptiste, additional, Ménard, Sandie, additional, Morlais, Isabelle, additional, Muhindo-Mavoko, Hypolite, additional, Musset, Lise, additional, Na-Bangchang, Kesara, additional, Nambozi, Michael, additional, Niaré, Karamoko, additional, Noedl, Harald, additional, Ouédraogo, Jean-Bosco, additional, Pillai, Dylan R., additional, Pradines, Bruno, additional, Quang-Phuc, Bui, additional, Ramharter, Michael, additional, Randrianarivelojosia, Milijaona, additional, Sattabongkot, Jetsumon, additional, Sheikh-Omar, Abdiqani, additional, Silué, Kigbafori D., additional, Sirima, Sodiomon B., additional, Sutherland, Colin, additional, Syafruddin, Din, additional, Tahar, Rachida, additional, Tang, Lin-Hua, additional, Touré, Offianan A., additional, Tshibangu-wa-Tshibangu, Patrick, additional, Vigan-Womas, Inès, additional, Warsame, Marian, additional, Wini, Lyndes, additional, Zakeri, Sedigheh, additional, Kim, Saorin, additional, Eam, Rotha, additional, Berne, Laura, additional, Khean, Chanra, additional, Chy, Sophy, additional, Ken, Malen, additional, Loch, Kaknika, additional, Canier, Lydie, additional, Duru, Valentine, additional, Legrand, Eric, additional, Barale, Jean-Christophe, additional, Stokes, Barbara, additional, Straimer, Judith, additional, Witkowski, Benoit, additional, Fidock, David A., additional, Rogier, Christophe, additional, Ringwald, Pascal, additional, Ariey, Frederic, additional, and Mercereau-Puijalon, Odile, additional

Published
2016
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41. Circulating antibodies against Plasmodium falciparum histidine-rich proteins 2 interfere with antigen detection by rapid diagnostic tests

Author

Ho, Mei-Fong, Baker, Joanne, Lee, Nelson, Luchavez, Jennifer, Ariey, Frederic, Nhem, Sina, Oyibo, Wellington, Bell, David, Gonzalez, Iveth, Chiodini, Peter, Gatton, Michelle, Cheng, Qin, McCarthy, James, Ho, Mei-Fong, Baker, Joanne, Lee, Nelson, Luchavez, Jennifer, Ariey, Frederic, Nhem, Sina, Oyibo, Wellington, Bell, David, Gonzalez, Iveth, Chiodini, Peter, Gatton, Michelle, Cheng, Qin, and McCarthy, James

Abstract

Background Rapid diagnostic tests (RDTs) for detection of Plasmodium falciparum infection that target P. falciparum histidine-rich protein 2 (PfHRP2), a protein that circulates in the blood of patients infected with this species of malaria, are widely used to guide case management. Understanding determinants of PfHRP2 availability in circulation is therefore essential to understanding the performance of PfHRP2-detecting RDTs. Methods The possibility that pre-formed host anti-PfHRP2 antibodies may block target antigen detection, thereby causing false negative test results was investigated in this study. Results Anti-PfHRP2 antibodies were detected in 19/75 (25%) of plasma samples collected from patients with acute malaria from Cambodia, Nigeria and the Philippines, as well as in 3/28 (10.7%) asymptomatic Solomon Islands residents. Pre-incubation of plasma samples from subjects with high-titre anti-PfHRP2 antibodies with soluble PfHRP2 blocked the detection of the target antigen on two of the three brands of RDTs tested, leading to false negative results. Pre-incubation of the plasma with intact parasitized erythrocytes resulted in a reduction of band intensity at the highest parasite density, and a reduction of lower detection threshold by ten-fold on all three brands of RDTs tested. Conclusions These observations indicate possible reduced sensitivity for diagnosis of P. falciparum malaria using PfHRP2-detecting RDTs among people with high levels of specific antibodies and low density infection, as well as possible interference with tests configured to detect soluble PfHRP2 in saliva or urine samples. Further investigations are required to assess the impact of pre-formed anti-PfHRP2 antibodies on RDT performance in different transmission settings.

Published
2014

42. Molecular surveillance for artemisinin resistance in Africa

Author

Roper, Cally, Alifrangis, Michael, Ariey, Frederic, Talisuna, Ambrose, Menard, Didier, Mercereau-Puijalon, Odile, Ringwald, Pascal, Roper, Cally, Alifrangis, Michael, Ariey, Frederic, Talisuna, Ambrose, Menard, Didier, Mercereau-Puijalon, Odile, and Ringwald, Pascal

Published
2014

43. Independent Emergence of Artemisinin Resistance Mutations Among Plasmodium falciparum in Southeast Asia

Author

Takala-Harrison, Shannon, primary, Jacob, Christopher G., additional, Arze, Cesar, additional, Cummings, Michael P., additional, Silva, Joana C., additional, Dondorp, Arjen M., additional, Fukuda, Mark M., additional, Hien, Tran Tinh, additional, Mayxay, Mayfong, additional, Noedl, Harald, additional, Nosten, Francois, additional, Kyaw, Myat P., additional, Nhien, Nguyen Thanh Thuy, additional, Imwong, Mallika, additional, Bethell, Delia, additional, Se, Youry, additional, Lon, Chanthap, additional, Tyner, Stuart D., additional, Saunders, David L., additional, Ariey, Frederic, additional, Mercereau-Puijalon, Odile, additional, Menard, Didier, additional, Newton, Paul N., additional, Khanthavong, Maniphone, additional, Hongvanthong, Bouasy, additional, Starzengruber, Peter, additional, Fuehrer, Hans-Peter, additional, Swoboda, Paul, additional, Khan, Wasif A., additional, Phyo, Aung Pyae, additional, Nyunt, Myaing M., additional, Nyunt, Myat H., additional, Brown, Tyler S., additional, Adams, Matthew, additional, Pepin, Christopher S., additional, Bailey, Jason, additional, Tan, John C., additional, Ferdig, Michael T., additional, Clark, Taane G., additional, Miotto, Olivo, additional, MacInnis, Bronwyn, additional, Kwiatkowski, Dominic P., additional, White, Nicholas J., additional, Ringwald, Pascal, additional, and Plowe, Christopher V., additional

Published
2014
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45. Global sequence variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum: implications for the performance of malaria rapid diagnostic tests

Author

Baker, Joanne, Ho, Mei-Fong, Pelecanos, Anita, Gatton, Michelle, Chen, Nanhua, Abdullah, Salim, Albertini, Audrey, Ariey, Frederic, Barnwell, John, Bell, David, Cunningham, Jane, Djalle, Djibrine, Echeverry, Diego, Gamboa, Dionicia, Hii, Jeffery, Kyaw, Myat Phone, Luchavez, Jennifer, Membi, Christopher, Menard, Didier, Murillo, Claribel, Nhem, Sina, Ogutu, Bernhards, Onyor, Pamela, Oyibo, Wellington, Wang, Shan Qing, McCarthy, James, Cheng, Qin, Baker, Joanne, Ho, Mei-Fong, Pelecanos, Anita, Gatton, Michelle, Chen, Nanhua, Abdullah, Salim, Albertini, Audrey, Ariey, Frederic, Barnwell, John, Bell, David, Cunningham, Jane, Djalle, Djibrine, Echeverry, Diego, Gamboa, Dionicia, Hii, Jeffery, Kyaw, Myat Phone, Luchavez, Jennifer, Membi, Christopher, Menard, Didier, Murillo, Claribel, Nhem, Sina, Ogutu, Bernhards, Onyor, Pamela, Oyibo, Wellington, Wang, Shan Qing, McCarthy, James, and Cheng, Qin

Abstract

Background Accurate diagnosis is essential for prompt and appropriate treatment of malaria. While rapid diagnostic tests (RDTs) offer great potential to improve malaria diagnosis, the sensitivity of RDTs has been reported to be highly variable. One possible factor contributing to variable test performance is the diversity of parasite antigens. This is of particular concern for Plasmodium falciparum histidine-rich protein 2 (PfHRP2)-detecting RDTs since PfHRP2 has been reported to be highly variable in isolates of the Asia-Pacific region. Methods The pfhrp2 exon 2 fragment from 458 isolates of P. falciparum collected from 38 countries was amplified and sequenced. For a subset of 80 isolates, the exon 2 fragment of histidine-rich protein 3 (pfhrp3) was also amplified and sequenced. DNA sequence and statistical analysis of the variation observed in these genes was conducted. The potential impact of the pfhrp2 variation on RDT detection rates was examined by analysing the relationship between sequence characteristics of this gene and the results of the WHO product testing of malaria RDTs: Round 1 (2008), for 34 PfHRP2-detecting RDTs. Results Sequence analysis revealed extensive variations in the number and arrangement of various repeats encoded by the genes in parasite populations world-wide. However, no statistically robust correlation between gene structure and RDT detection rate for P. falciparum parasites at 200 parasites per microlitre was identified. Conclusions The results suggest that despite extreme sequence variation, diversity of PfHRP2 does not appear to be a major cause of RDT sensitivity variation.

Published
2010

46. Sub-microscopic malaria cases and mixed malaria infection in a remote area of high malaria endemicity in Rattanakiri province, Cambodia: implication for malaria elimination

Author

Steenkeste, Nicolas, Rogers, William O., Okell, Lucy, Jeanne, Isabelle, Incardona, Sandra, Duval, Linda, Chy, Sophy, Hewitt, Sean, Chou, Monidarin, Socheat, Duong, Babin, Francois-Xavier, Ariey, Frederic, Rogier, Christophe, Steenkeste, Nicolas, Rogers, William O., Okell, Lucy, Jeanne, Isabelle, Incardona, Sandra, Duval, Linda, Chy, Sophy, Hewitt, Sean, Chou, Monidarin, Socheat, Duong, Babin, Francois-Xavier, Ariey, Frederic, and Rogier, Christophe

Abstract

BACKGROUND: Malaria microscopy and rapid diagnostic tests are insensitive for very low-density parasitaemia. This insensitivity may lead to missed asymptomatic sub-microscopic parasitaemia, a potential reservoir for infection. Similarly, mixed infections and interactions between Plasmodium species may be missed. The objectives were first to develop a rapid and sensitive PCR-based diagnostic method to detect low parasitaemia and mixed infections, and then to investigate the epidemiological importance of sub-microscopic and mixed infections in Rattanakiri Province, Cambodia. METHODS: A new malaria diagnostic method, using restriction fragment length polymorphism analysis of the cytochrome b genes of the four human Plasmodium species and denaturing high performance liquid chromatography, has been developed. The results of this RFLP-dHPLC method have been compared to 1) traditional nested PCR amplification of the 18S rRNA gene, 2) sequencing of the amplified fragments of the cytochrome b gene and 3) microscopy. Blood spots on filter paper and Giemsa-stained blood thick smears collected in 2001 from 1,356 inhabitants of eight villages of Rattanakiri Province have been analysed by the RFLP-dHPLC method and microscopy to assess the prevalence of sub-microscopic and mixed infections. RESULTS: The sensitivity and specificity of the new RFLP-dHPLC was similar to that of the other molecular methods. The RFLP-dHPLC method was more sensitive and specific than microscopy, particularly for detecting low-level parasitaemia and mixed infections. In Rattanakiri Province, the prevalences of Plasmodium falciparum and Plasmodium vivax were approximately two-fold and three-fold higher, respectively, by RFLP-dHPLC (59% and 15%, respectively) than by microscopy (28% and 5%, respectively). In addition, Plasmodium ovale and Plasmodium malariae were never detected by microscopy, while they were detected by RFLP-dHPLC, in 11.2% and 1.3% of the blood samples, respectively. Moreover, the proport

Published
2010

48. Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

Author

Takala-Harrison, Shannon, primary, Clark, Taane G., additional, Jacob, Christopher G., additional, Cummings, Michael P., additional, Miotto, Olivo, additional, Dondorp, Arjen M., additional, Fukuda, Mark M., additional, Nosten, Francois, additional, Noedl, Harald, additional, Imwong, Mallika, additional, Bethell, Delia, additional, Se, Youry, additional, Lon, Chanthap, additional, Tyner, Stuart D., additional, Saunders, David L., additional, Socheat, Duong, additional, Ariey, Frederic, additional, Phyo, Aung Pyae, additional, Starzengruber, Peter, additional, Fuehrer, Hans-Peter, additional, Swoboda, Paul, additional, Stepniewska, Kasia, additional, Flegg, Jennifer, additional, Arze, Cesar, additional, Cerqueira, Gustavo C., additional, Silva, Joana C., additional, Ricklefs, Stacy M., additional, Porcella, Stephen F., additional, Stephens, Robert M., additional, Adams, Matthew, additional, Kenefic, Leo J., additional, Campino, Susana, additional, Auburn, Sarah, additional, MacInnis, Bronwyn, additional, Kwiatkowski, Dominic P., additional, Su, Xin-zhuan, additional, White, Nicholas J., additional, Ringwald, Pascal, additional, and Plowe, Christopher V., additional

Published
2012
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50. Plasmodium knowlesiInfection in Humans, Cambodia, 2007–2010

Author

Khim, Nimol, primary, Siv, Sovannaroth, additional, Kim, Saorin, additional, Mueller, Tara, additional, Fleischmann, Erna, additional, Singh, Balbir, additional, Divis, Paul Cliff Simon, additional, Steenkeste, Nicolas, additional, Duval, Linda, additional, Bouchier, Christiane, additional, Duong, Socheat, additional, Ariey, Frederic, additional, and Ménard, Didier, additional

Published
2011
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