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3. Efficacy of a synbiotic in the management of adults with Attention-Deficit and Hyperactivity Disorder and/or Borderline Personality Disorder and high levels of irritability: Results from a multicenter, randomized, placebo-controlled, “basket” trial

Author

Arteaga-Henríquez, Gara, Ramos-Sayalero, Carolina, Ibañez-Jimenez, Pol, Karina Rosales-Ortiz, Silvia, Kilencz, Tünde, Schiweck, Carmen, Schnorr, Isabel, Siegl, Anne, Arias-Vasquez, Alejandro, Bitter, István, Fadeuilhe, Christian, Ferrer, Marc, Lavebratt, Catharina, Matura, Silke, Reif, Andreas, Réthelyi, János M., Richarte, Vanesa, Rommelse, Nanda, and Antoni Ramos-Quiroga, Josep

Published
2024
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5. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex.

Author

Guadalupe, Tulio, Mathias, Samuel R, vanErp, Theo GM, Whelan, Christopher D, Zwiers, Marcel P, Abe, Yoshinari, Abramovic, Lucija, Agartz, Ingrid, Andreassen, Ole A, Arias-Vásquez, Alejandro, Aribisala, Benjamin S, Armstrong, Nicola J, Arolt, Volker, Artiges, Eric, Ayesa-Arriola, Rosa, Baboyan, Vatche G, Banaschewski, Tobias, Barker, Gareth, Bastin, Mark E, Baune, Bernhard T, Blangero, John, Bokde, Arun LW, Boedhoe, Premika SW, Bose, Anushree, Brem, Silvia, Brodaty, Henry, Bromberg, Uli, Brooks, Samantha, Büchel, Christian, Buitelaar, Jan, Calhoun, Vince D, Cannon, Dara M, Cattrell, Anna, Cheng, Yuqi, Conrod, Patricia J, Conzelmann, Annette, Corvin, Aiden, Crespo-Facorro, Benedicto, Crivello, Fabrice, Dannlowski, Udo, de Zubicaray, Greig I, de Zwarte, Sonja MC, Deary, Ian J, Desrivières, Sylvane, Doan, Nhat Trung, Donohoe, Gary, Dørum, Erlend S, Ehrlich, Stefan, Espeseth, Thomas, Fernández, Guillén, Flor, Herta, Fouche, Jean-Paul, Frouin, Vincent, Fukunaga, Masaki, Gallinat, Jürgen, Garavan, Hugh, Gill, Michael, Suarez, Andrea Gonzalez, Gowland, Penny, Grabe, Hans J, Grotegerd, Dominik, Gruber, Oliver, Hagenaars, Saskia, Hashimoto, Ryota, Hauser, Tobias U, Heinz, Andreas, Hibar, Derrek P, Hoekstra, Pieter J, Hoogman, Martine, Howells, Fleur M, Hu, Hao, Hulshoff Pol, Hilleke E, Huyser, Chaim, Ittermann, Bernd, Jahanshad, Neda, Jönsson, Erik G, Jurk, Sarah, Kahn, Rene S, Kelly, Sinead, Kraemer, Bernd, Kugel, Harald, Kwon, Jun Soo, Lemaitre, Herve, Lesch, Klaus-Peter, Lochner, Christine, Luciano, Michelle, Marquand, Andre F, Martin, Nicholas G, Martínez-Zalacaín, Ignacio, Martinot, Jean-Luc, Mataix-Cols, David, Mather, Karen, McDonald, Colm, McMahon, Katie L, Medland, Sarah E, Menchón, José M, Morris, Derek W, Mothersill, Omar, Maniega, Susana Munoz, and Mwangi, Benson

Subjects
Brain, Humans, Magnetic Resonance Imaging, Organ Size, Aging, Sex Characteristics, Quantitative Trait, Heritable, Adolescent, Adult, Aged, Middle Aged, Female, Male, Functional Laterality, Meta-Analysis as Topic, Young Adult, Age, Enigma, Handedness, Heritability, Meta-analysis, Sex, Subcortical brain asymmetry, Quantitative Trait, Heritable, Medical and Health Sciences, Psychology and Cognitive Sciences, Experimental Psychology
Abstract

The two hemispheres of the human brain differ functionally and structurally. Despite over a century of research, the extent to which brain asymmetry is influenced by sex, handedness, age, and genetic factors is still controversial. Here we present the largest ever analysis of subcortical brain asymmetries, in a harmonized multi-site study using meta-analysis methods. Volumetric asymmetry of seven subcortical structures was assessed in 15,847 MRI scans from 52 datasets worldwide. There were sex differences in the asymmetry of the globus pallidus and putamen. Heritability estimates, derived from 1170 subjects belonging to 71 extended pedigrees, revealed that additive genetic factors influenced the asymmetry of these two structures and that of the hippocampus and thalamus. Handedness had no detectable effect on subcortical asymmetries, even in this unprecedented sample size, but the asymmetry of the putamen varied with age. Genetic drivers of asymmetry in the hippocampus, thalamus and basal ganglia may affect variability in human cognition, including susceptibility to psychiatric disorders.

Published
2017

10. Epigenetic signature for attention-deficit/hyperactivity disorder: identification of miR-26b-5p, miR-185-5p, and miR-191-5p as potential biomarkers in peripheral blood mononuclear cells

Author

Sánchez-Mora, Cristina, Soler Artigas, María, Garcia-Martínez, Iris, Pagerols, Mireia, Rovira, Paula, Richarte, Vanesa, Corrales, Montse, Fadeuilhe, Christian, Padilla, Natàlia, de la Cruz, Xavier, Franke, Barbara, Arias-Vásquez, Alejandro, Casas, Miguel, Ramos-Quiroga, Josep-Antoni, and Ribasés, Marta

Published
2019
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11. Dynamic Modelling of Mental Resilience in Young Adults: Protocol for a Longitudinal Observational Study (DynaM-OBS)

Author

Wackerhagen, Carolin, primary, Veer, Ilya M, additional, van Leeuwen, Judith M C, additional, Reppmann, Zala, additional, Riepenhausen, Antje, additional, Bögemann, Sophie A, additional, Mor, Netali, additional, Puhlmann, Lara M C, additional, Uściƚko, Aleksandra, additional, Zerban, Matthias, additional, Mituniewicz, Julian, additional, Lerner, Avigail, additional, Yuen, Kenneth S L, additional, Köber, Göran, additional, Marciniak, Marta A, additional, Pooseh, Shakoor, additional, Weermeijer, Jeroen, additional, Arias-Vásquez, Alejandro, additional, Binder, Harald, additional, de Raedt, Walter, additional, Kleim, Birgit, additional, Myin-Germeys, Inez, additional, Roelofs, Karin, additional, Timmer, Jens, additional, Tüscher, Oliver, additional, Hendler, Talma, additional, Kobylińska, Dorota, additional, Hermans, Erno J, additional, Kalisch, Raffael, additional, and Walter, Henrik, additional

Published
2023
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13. ENIGMA and the individual: Predicting factors that affect the brain in 35 countries worldwide

Author

Thompson, Paul M., Andreassen, Ole A., Arias-Vasquez, Alejandro, Bearden, Carrie E., Boedhoe, Premika S., Brouwer, Rachel M., Buckner, Randy L., Buitelaar, Jan K., Bulayeva, Kazima B., Cannon, Dara M., Cohen, Ronald A., Conrod, Patricia J., Dale, Anders M., Deary, Ian J., Dennis, Emily L., de Reus, Marcel A., Desrivieres, Sylvane, Dima, Danai, Donohoe, Gary, Fisher, Simon E., Fouche, Jean-Paul, Francks, Clyde, Frangou, Sophia, Franke, Barbara, Ganjgahi, Habib, Garavan, Hugh, Glahn, David C., Grabe, Hans J., Guadalupe, Tulio, Gutman, Boris A., Hashimoto, Ryota, Hibar, Derrek P., Holland, Dominic, Hoogman, Martine, Pol, Hilleke E. Hulshoff, Hosten, Norbert, Jahanshad, Neda, Kelly, Sinead, Kochunov, Peter, Kremen, William S., Lee, Phil H., Mackey, Scott, Martin, Nicholas G., Mazoyer, Bernard, McDonald, Colm, Medland, Sarah E., Morey, Rajendra A., Nichols, Thomas E., Paus, Tomas, Pausova, Zdenka, Schmaal, Lianne, Schumann, Gunter, Shen, Li, Sisodiya, Sanjay M., Smit, Dirk J.A., Smoller, Jordan W., Stein, Dan J., Stein, Jason L., Toro, Roberto, Turner, Jessica A., van den Heuvel, Martijn P., van den Heuvel, Odile L., van Erp, Theo G.M., van Rooij, Daan, Veltman, Dick J., Walter, Henrik, Wang, Yalin, Wardlaw, Joanna M., Whelan, Christopher D., Wright, Margaret J., and Ye, Jieping

Published
2017
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15. A longitudinal study of the gut microbiota during the first three years of life: Links with problem behavior and executive functions at preschool age

Author

Willemsen, Yvonne, Ou, Yangwenshan, Belzer, Clara, Arias Vásquez, Alejandro, Smidt, Hauke, Beijers, Roseriet, de Weerth, Carolina, Willemsen, Yvonne, Ou, Yangwenshan, Belzer, Clara, Arias Vásquez, Alejandro, Smidt, Hauke, Beijers, Roseriet, and de Weerth, Carolina

Abstract

Early life is a sensitive period when microbiota-gut-brain interactions may have important impact on development. This study investigated the associations of the gut microbiota in the first three years of life (two, six, and 12 weeks, and one and three years) with problem behavior and executive functions in N = 64 three-year-old children. Higher relative abundance of Streptococcus at the age of two weeks, as well as its trajectory over time (including ages two, six and 12 weeks, and one and three years), was related to worse executive functions. Higher relative abundance of [Ruminococcus] torques group at the age of three years, as well as its trajectory from one to three years, was associated with less internalizing behavior. Besides, several robust age-specific associations were identified: higher Bifidobacterium relative abundance (age three years) was associated with more internalizing and externalizing issues; higher Blautia relative abundance (age three years) was linked to less internalizing behavior; and increased relative abundance of an unidentified Enterobacteriaceae genus (age two weeks) was related to more externalizing behavior. Our findings provide important longitudinal evidence that early-life gut microbiota may be linked to behavioral and cognitive development in low-risk children.

Published
2023

18. Quantitative Linkage for Autism Spectrum Disorders Symptoms in Attention-Deficit/Hyperactivity Disorder: Significant Locus on Chromosome 7q11

Author

Nijmeijer, Judith S., Arias-Vásquez, Alejandro, and Rommelse, Nanda N.

Abstract

We studied 261 ADHD probands and 354 of their siblings to assess quantitative trait loci associated with autism spectrum disorder symptoms (as measured by the Children's Social Behavior Questionnaire (CSBQ) using a genome-wide linkage approach, followed by locus-wide association analysis. A genome-wide significant locus for the CSBQ subscale addressing social interaction was found on chromosome 7q11, with suggestive signals supporting this locus on three other CSBQ subscales. We identified two other suggestive loci for the CSBQ total scale and individual subscales on chromosomes 4q35 and 7p12. Fine-mapping the significantly linked locus resulted in interesting candidate genes, although their association was not significant after permutation testing.

Published
2014
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22. Corrigendum to “Efficacy of a synbiotic in the management of adults with Attention-Deficit and Hyperactivity Disorder and/or Borderline Personality Disorder and high levels of irritability: Results from a multicenter, randomized, placebo-controlled, “basket” trial” [Brain Behav. Immun. 120 (2024) 360–371]

Author

Arteaga-Henríquez, Gara, Ramos-Sayalero, Carolina, Ibañez-Jimenez, Pol, Rosales-Ortiz, Silvia Karina, Kilencz, Tünde, Schiweck, Carmen, Schnorr, Isabel, Siegl, Anne, Arias-Vasquez, Alejandro, Bitter, István, Fadeuilhe, Christian, Ferrer, Marc, Lavebratt, Catharina, Matura, Silke, Reif, Andreas, Réthelyi, Janós M., Richarte, Vanesa, Rommelse, Nanda, and Antoni Ramos-Quiroga, Josep

Published
2024
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23. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

Author

Guadalupe, Tulio, Mathias, Samuel R., vanErp, Theo G. M., Whelan, Christopher D., Zwiers, Marcel P., Abe, Yoshinari, Abramovic, Lucija, Agartz, Ingrid, Andreassen, Ole A., Arias-Vásquez, Alejandro, Aribisala, Benjamin S., Armstrong, Nicola J., Arolt, Volker, Artiges, Eric, Ayesa-Arriola, Rosa, Baboyan, Vatche G., Banaschewski, Tobias, Barker, Gareth, Bastin, Mark E., Baune, Bernhard T., Blangero, John, Bokde, Arun L.W., Boedhoe, Premika S.W., Bose, Anushree, Brem, Silvia, Brodaty, Henry, Bromberg, Uli, Brooks, Samantha, Büchel, Christian, Buitelaar, Jan, Calhoun, Vince D., Cannon, Dara M., Cattrell, Anna, Cheng, Yuqi, Conrod, Patricia J., Conzelmann, Annette, Corvin, Aiden, Crespo-Facorro, Benedicto, Crivello, Fabrice, Dannlowski, Udo, de Zubicaray, Greig I., de Zwarte, Sonja M.C., Deary, Ian J., Desrivières, Sylvane, Doan, Nhat Trung, Donohoe, Gary, Dørum, Erlend S., Ehrlich, Stefan, Espeseth, Thomas, Fernández, Guillén, Flor, Herta, Fouche, Jean-Paul, Frouin, Vincent, Fukunaga, Masaki, Gallinat, Jürgen, Garavan, Hugh, Gill, Michael, Suarez, Andrea Gonzalez, Gowland, Penny, Grabe, Hans J., Grotegerd, Dominik, Gruber, Oliver, Hagenaars, Saskia, Hashimoto, Ryota, Hauser, Tobias U., Heinz, Andreas, Hibar, Derrek P., Hoekstra, Pieter J., Hoogman, Martine, Howells, Fleur M., Hu, Hao, Hulshoff Pol, Hilleke E., Huyser, Chaim, Ittermann, Bernd, Jahanshad, Neda, Jönsson, Erik G., Jurk, Sarah, Kahn, Rene S., Kelly, Sinead, Kraemer, Bernd, Kugel, Harald, Kwon, Jun Soo, Lemaitre, Herve, Lesch, Klaus-Peter, Lochner, Christine, Luciano, Michelle, Marquand, Andre F., Martin, Nicholas G., Martínez-Zalacaín, Ignacio, Martinot, Jean-Luc, Mataix-Cols, David, Mather, Karen, McDonald, Colm, McMahon, Katie L., Medland, Sarah E., Menchón, José M., Morris, Derek W., Mothersill, Omar, Maniega, Susana Munoz, Mwangi, Benson, Nakamae, Takashi, Nakao, Tomohiro, Narayanaswaamy, Janardhanan C., Nees, Frauke, Nordvik, Jan E., Onnink, A. Marten H., Opel, Nils, Ophoff, Roel, Paillère Martinot, Marie-Laure, Papadopoulos Orfanos, Dimitri, Pauli, Paul, Paus, Tomáš, Poustka, Luise, Reddy, Janardhan YC., Renteria, Miguel E., Roiz-Santiáñez, Roberto, Roos, Annerine, Royle, Natalie A., Sachdev, Perminder, Sánchez-Juan, Pascual, Schmaal, Lianne, Schumann, Gunter, Shumskaya, Elena, Smolka, Michael N., Soares, Jair C., Soriano-Mas, Carles, Stein, Dan J., Strike, Lachlan T., Toro, Roberto, Turner, Jessica A., Tzourio-Mazoyer, Nathalie, Uhlmann, Anne, Hernández, Maria Valdés, van den Heuvel, Odile A., van der Meer, Dennis, van Haren, Neeltje E.M ., Veltman, Dick J., Venkatasubramanian, Ganesan, Vetter, Nora C., Vuletic, Daniella, Walitza, Susanne, Walter, Henrik, Walton, Esther, Wang, Zhen, Wardlaw, Joanna, Wen, Wei, Westlye, Lars T., Whelan, Robert, Wittfeld, Katharina, Wolfers, Thomas, Wright, Margaret J., Xu, Jian, Xu, Xiufeng, Yun, Je-Yeon, Zhao, JingJing, Franke, Barbara, Thompson, Paul M., Glahn, David C., Mazoyer, Bernard, Fisher, Simon E., and Francks, Clyde

Published
2016
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24. Candidate Genetic Pathways for Attention-Deficit/Hyperactivity Disorder (ADHD) Show Association to Hyperactive/Impulsive Symptoms in Children With ADHD

Author

Bralten, Janita, Franke, Barbara, Waldman, Irwin, Rommelse, Nanda, Hartman, Catharina, Asherson, Philip, Banaschewski, Tobias, Ebstein, Richard P., Gill, Michael, Miranda, Ana, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Sergeant, Joseph A., Oosterlaan, Jaap, Sonuga-Barke, Edmund, Steinhausen, Hans-Christoph, Faraone, Stephen V., Buitelaar, Jan K., and Arias-Vásquez, Alejandro

Published
2013
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29. Study protocol description: Dynamic Modelling of Resilience - Observational Study (DynaM-OBS) (Preprint)

Author

Wackerhagen, Carolin, primary, Veer, Ilya M., additional, van Leeuwen, Judith M. C., additional, Reppmann, Zala, additional, Riepenhausen, Antje, additional, Bögemann, Sophie A., additional, Mor, Netali, additional, Puhlmann, Lara M.C., additional, Uściƚko, Aleksandra, additional, Zerban, Matthias, additional, Yuen, Kenneth S. L., additional, Köber, Göran, additional, Pooseh, Shakoor, additional, Weermeijer, Jeroen, additional, Marciniak, Marta A., additional, Arias-Vásquez, Alejandro, additional, Binder, Harald, additional, de Raedt, Walter, additional, Kleim, Birgit, additional, Myin-Germeys, Inez, additional, Roelofs, Karin, additional, Timmer, Jens, additional, Tüscher, Oliver, additional, Hendler, Talma, additional, Hermans, Erno J., additional, Kalisch, Raffael, additional, Kobylińska, Dorota, additional, and Walter, Henrik, additional

Published
2022
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30. Genetic background of grey matter brain networks related to attention-deficit/hyperactivity disorder

Author

Schoenmacker, Gido H., primary, Duan, Kuaikuai, additional, Rootes-Murdy, Kelly, additional, Jiang, Wenhao, additional, Hoekstra, Pieter J., additional, Hartman, Catharina A., additional, Oosterlaan, Jaap, additional, Hoogman, Martine, additional, Franke, Barbara, additional, Turner, Jessica A., additional, Liu, Jingyu, additional, Claassen, Tom, additional, Heskes, Tom, additional, Buitelaar, Jan K., additional, and Arias Vásquez, Alejandro, additional

Published
2022
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32. Identifying Loci for the Overlap Between Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder Using a Genome-wide QTL Linkage Approach

Author

Nijmeijer, Judith S., Arias-Vásquez, Alejandro, Rommelse, Nanda N.J., Altink, Marieke E., Anney, Richard J.L., Asherson, Philip, Banaschewski, Tobias, Buschgens, Cathelijne J.M., Fliers, Ellen A., Gill, Michael, Minderaa, Ruud B., Poustka, Luise, Sergeant, Joseph A., Buitelaar, Jan K., Franke, Barbara, Ebstein, Richard P., Miranda, Ana, Mulas, Fernando, Oades, Robert D., Roeyers, Herbert, Rothenberger, Aribert, Sonuga-Barke, Edmund J.S., Steinhausen, Hans-Christoph, Faraone, Stephen V., Hartman, Catharina A., and Hoekstra, Pieter J.

Published
2010
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35. Gene-Environment Interactions in Attention-Deficit/Hyperactivity Disorder Symptom Dimensions : The Role of Unhealthy Food Habits

Author

Li, Lin, Taylor, Mark J., Bälter, Katarina, Xie, Tian, Solberg, Berit Skretting, Haavik, Jan, Arias Vásquez, Alejandro, Hartman, Catharina A., Larsson, Henrik, Li, Lin, Taylor, Mark J., Bälter, Katarina, Xie, Tian, Solberg, Berit Skretting, Haavik, Jan, Arias Vásquez, Alejandro, Hartman, Catharina A., and Larsson, Henrik

Abstract

Background: Dietary habits were investigated as environmental risk factors for Attention-Deficit/Hyperactivity Disorder (ADHD). However, no previous studies explored the effects of dietary factors on modifying the role of genetic factors on ADHD. Methods: Based on a Swedish population-based twin study with 1518 twin pairs aged 20-47 years, we tested whether the importance of genetic and environmental effects on ADHD varied as a function of dietary habits. Self-reported dietary habits and ADHD symptoms were collected. Twin methods were used to test the degree to which high-sugar and unhealthy food intake moderated the genetic and environmental influences on ADHD symptoms. Results: In middle-aged adults, genetic influences on inattention symptoms were statistically significantly higher among individuals with higher levels of high-sugar (45%, 95%CI: 25-54%) and unhealthy food intake (51%, 95%CI: 31-60%), compared with those with lower levels of consumption of high-sugar (36%, 95%CI: 25-47%) and unhealthy foods (30%, 95%CI: 20-41%). Similar patterns were also found for the associations between hyperactivity/impulsivity and high-sugar/unhealthy food intake, even though the moderation effects were not statistically significant. Conclusion: The present study suggests that genetic factors play a more prominent role in individual differences of ADHD symptoms in the presence of the high consumption of sugar and unhealthy foods. Future longitudinal studies with multiple assessments of ADHD and dietary habits are needed to replicate our findings.

Published
2021
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37. Sialylated human milk oligosaccharides program cognitive development through a non-genomic transmission mode

Author

Hauser, Jonas, primary, Pisa, Edoardo, additional, Arias Vásquez, Alejandro, additional, Tomasi, Flavio, additional, Traversa, Alice, additional, Chiodi, Valentina, additional, Martin, Francois-Pierre, additional, Sprenger, Norbert, additional, Lukjancenko, Oksana, additional, Zollinger, Alix, additional, Metairon, Sylviane, additional, Schneider, Nora, additional, Steiner, Pascal, additional, Martire, Alberto, additional, Caputo, Viviana, additional, and Macrì, Simone, additional

Published
2021
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39. Attention-deficit/hyperactivity disorder symptoms and dietary habits in adulthood : A large population-based twin study in Sweden

Author

Li, Lin, Taylor, Mark J., Bälter, Katarina, Kuja-Halkola, Ralf, Chen, Qi, Hegvik, Tor-Arne, Tate, Ashley E., Chang, Zheng, Arias-Vásquez, Alejandro, Hartman, Catharina A., Larsson, Henrik, Li, Lin, Taylor, Mark J., Bälter, Katarina, Kuja-Halkola, Ralf, Chen, Qi, Hegvik, Tor-Arne, Tate, Ashley E., Chang, Zheng, Arias-Vásquez, Alejandro, Hartman, Catharina A., and Larsson, Henrik

Abstract

Associations between adult attention-deficit/hyperactivity disorder (ADHD) symptoms and dietary habits have not been well established and the underlying mechanisms remain unclear. We explored these associations using a Swedish population-based twin study with 17,999 individuals aged 20-47 years. We estimated correlations between inattention and hyperactivity/impulsivity with dietary habits and fitted twin models to determine the genetic and environmental contributions. Dietary habits were defined as (a) consumption of food groups, (b) consumption of food items rich in particular macronutrients, and (c) healthy and unhealthy dietary patterns. At the phenotypic level, inattention was positively correlated with seafood, high-fat, high-sugar, high-protein food consumptions, and unhealthy dietary pattern, with correlation coefficients ranging from 0.03 (95%CI: 0.01, 0.05) to 0.13 (95% CI: 0.11, 0.15). Inattention was negatively correlated with fruits, vegetables consumptions and healthy dietary pattern, with correlation coefficients ranging from -0.06 (95%CI: -0.08, -0.04) to -0.07 (95%CI: -0.09, -0.05). Hyperactivity/impulsivity and dietary habits showed similar but weaker patterns compared to inattention. All associations remained stable across age, sex and socioeconomic status. Nonshared environmental effects contributed substantially to the correlations of inattention (56-60%) and hyperactivity/impulsivity (63-80%) with dietary habits. The highest and lowest genetic correlations were between inattention and high-sugar food (rA = .16, 95% CI: 0.07, 0.25), and between hyperactivity/impulsivity and unhealthy dietary pattern (rA = .05, 95% CI: -0.05, 0.14), respectively. We found phenotypic and etiological overlap between ADHD and dietary habits, although these associations were weak. Our findings contribute to a better understanding of common etiological pathways between ADHD symptoms and various dietary habits.

Published
2020
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40. Cross-disorder genetic analyses implicate dopaminergic signaling as a biological link between adttention-eficit/hyperactivity disorder and obesity measures

Author

Mota, Nina Roth, Poelmans, Geert, Klein, Marieke, Torrico, Bàrbara, Fernàndez-Castillo, Noèlia, Cormand, Bru, Reif, Andreas, Franke, Barbara, Arias Vásquez, Alejandro, Mota, Nina Roth, Poelmans, Geert, Klein, Marieke, Torrico, Bàrbara, Fernàndez-Castillo, Noèlia, Cormand, Bru, Reif, Andreas, Franke, Barbara, and Arias Vásquez, Alejandro

Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) and obesity are frequently comorbid, genetically correlated, and share brain substrates. The biological mechanisms driving this association are unclear, but candidate systems, like dopaminergic neurotransmission and circadian rhythm, have been suggested. Our aim was to identify the biological mechanisms underpinning the genetic link between ADHD and obesity measures and investigate associations of overlapping genes with brain volumes. We tested the association of dopaminergic and circadian rhythm gene sets with ADHD, body mass index (BMI), and obesity (using GWAS data of N = 53,293, N = 681,275, and N = 98,697, respectively). We then conducted genome-wide ADHD–BMI and ADHD–obesity gene-based meta-analyses, followed by pathway enrichment analyses. Finally, we tested the association of ADHD–BMI overlapping genes with brain volumes (primary GWAS data N = 10,720–10,928; replication data N = 9428). The dopaminergic gene set was associated with both ADHD (P = 5.81 × 10−3) and BMI (P = 1.63 × 10−5); the circadian rhythm was associated with BMI (P = 1.28 × 10−3). The genome-wide approach also implicated the dopaminergic system, as the Dopamine-DARPP32 Feedback in cAMP Signaling pathway was enriched in both ADHD–BMI and ADHD–obesity results. The ADHD–BMI overlapping genes were associated with putamen volume (P = 7.7 × 10−3; replication data P = 3.9 × 10−2)—a brain region with volumetric reductions in ADHD and BMI and linked to inhibitory control. Our findings suggest that dopaminergic neurotransmission, partially through DARPP-32-dependent signaling and involving the putamen, is a key player underlying the genetic overlap between ADHD and obesity measures. Uncovering shared etiological factors underlying the frequently observed ADHD–obesity comorbidity may have important implications in terms of prevention and/or efficient treatment of these conditions.

Published
2020

42. Genome-wide association uncovers shared genetic effects among personality traits and mood states

Author

Luciano, Michelle, Huffman, Jennifer E., Arias-Vásquez, Alejandro, Vinkhuyzen, Anna A.E., Middeldorp, Christel M., Giegling, Ina, Payton, Antony, Davies, Gail, Zgaga, Lina, Janzing, Joost, Ke, Xiayi, Galesloot, Tessel, Hartmann, Annette M., Ollier, William, Tenesa, Albert, Hayward, Caroline, Verhagen, Maaike, Montgomery, Grant W., Hottenga, Jouke-Jan, Konte, Bettina, Starr, John M., Vitart, Veronique, Vos, Pieter E., Madden, Pamela A.F., Willemsen, Gonneke, Konnerth, Heike, Horan, Michael A., Porteous, David J., Campbell, Harry, Vermeulen, Sita H., Heath, Andrew C., Wright, Alan, Polasek, Ozren, Kovacevic, Sanja B., Hastie, Nicholas D., Franke, Barbara, Boomsma, Dorret I., Martin, Nicholas G., Rujescu, Dan, Wilson, James F., Buitelaar, Jan, Pendleton, Neil, Rudan, Igor, and Deary, Ian J.

Published
2012
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43. Attention‐deficit/hyperactivity disorder symptoms and dietary habits in adulthood: A large population‐based twin study in Sweden

Author

Li, Lin, primary, Taylor, Mark J., additional, Bälter, Katarina, additional, Kuja‐Halkola, Ralf, additional, Chen, Qi, additional, Hegvik, Tor‐Arne, additional, Tate, Ashley E., additional, Chang, Zheng, additional, Arias‐Vásquez, Alejandro, additional, Hartman, Catharina A., additional, and Larsson, Henrik, additional

Published
2020
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44. The dopamine receptor D4 7-repeat allele and prenatal smoking in ADHD-affected children and their unaffected siblings: no gene-environment interaction

Author

Altink, Marieke E., Arias-Vásquez, Alejandro, Franke, Barbara, Slaats -Willemse, Dorine I.E., Buschgens, Cathelijne J.M., Rommelse, Nanda N.J., Fliers, Ellen A., Anney, Richard, Brookes, Keeley-Joanne, Chen, Wai, Gill, Michael, Mulligan, Aisling, Sonuga-Barke, Edmund, Thompson, Margaret, Sergeant, Joseph A., Faraone, Stephen V., Asherson, Philip, and Buitelaar, Jan K.

Published
2008
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46. Cross-disorder genetic analyses implicate dopaminergic signaling as a biological link between attention-deficit/hyperactivity disorder and obesity measures

Author

Mota, Nina Roth, Poelmans, Geert, Klein, Marieke, Torrico, Bàrbara, Fernàndez-Castillo, Noèlia, Cormand, Bru, Reif, Andreas, Franke, Barbara, Arias Vásquez, Alejandro, Mota, Nina Roth, Poelmans, Geert, Klein, Marieke, Torrico, Bàrbara, Fernàndez-Castillo, Noèlia, Cormand, Bru, Reif, Andreas, Franke, Barbara, and Arias Vásquez, Alejandro

Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) is frequently comorbid with other psychiatric disorders and also with somatic conditions, such as obesity. In addition to the clinical overlap, significant genetic correlations have been found between ADHD and obesity as well as body mass index (BMI). The biological mechanisms driving this association are largely unknown, but some candidate systems, like dopaminergic neurotransmission and circadian rhythm, have been suggested. Our aim was to identify the biological mechanisms underpinning the link between ADHD and obesity measures. Using the largest GWAS summary statistics currently available for ADHD (N=53,293), BMI (N=681,275), and obesity (N=98,697), we first tested the association of dopaminergic and circadian rhythm gene sets with each phenotype. This hypothesis-driven approach showed that the dopaminergic gene set was associated with both ADHD (P=5.81×10−3) and BMI (P=1.63×10−5), while the circadian rhythm gene set was associated with BMI only (P=1.28×10−3). We then took a data-driven approach by conducting genome-wide ADHD-BMI and ADHD-obesity gene-based meta-analyses, followed by pathway enrichment analyses. This approach further supported the implication of dopaminergic signaling in the link between ADHD and obesity measures, as the Dopamine-DARPP32 Feedback in cAMP Signaling pathway was significantly enriched in both the ADHD-BMI and ADHD-obesity gene-based meta-analysis results. Our findings suggest that dopaminergic neurotransmission, partially through DARPP-32-dependent signaling, is a key player underlying the genetic overlap between ADHD and obesity measures. Uncovering the shared etiological factors underlying the frequently observed ADHD-obesity comorbidity may have important implications in terms of preventive interventions and/or efficient treatment of these conditions.

Published
2019

47. Chapter One - Multisite Metaanalysis of Image-Wide Genome-Wide Associations With Morphometry

Author

Jahanshad, Neda, Roshchupkin, Gennady, Faskowitz, Joshua, Hibar, Derrek P., Gutman, Boris A., Adams, Hieab H.H., Niessen, Wiro J., Vernooij, Meike W., Ikram, M. Arfan, Zwiers, Marcel P., Arias-Vasquez, Alejandro, Franke, Barbara, Ing, Alex, Desrivieres, Sylvane, Schumann, Gunter, de Zubicaray, Greig I., McMahon, Katie L., Medland, Sarah E., Wright, Margaret J., and Thompson, Paul M.

Published
2018
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