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Background: Oxygen deprivation (OD) is a critical condition that can lead to brain damage and even death. Current hypoxia management approaches are limited in effectiveness. Centella asiatica, known for its neuroprotective properties, offers a potential alternative for OD treatment. Aim: This study aims to investigate the neuroprotective effects of Centella asiatica (CA) on the expression of Brain-Derived Neurotrophic Factor (BDNF) and Vesicular Glutamate Transporter 1 (VGLUT1) in zebrafish larvae under oxygen-deficient conditions. Methods: Zebrafish embryos were subjected to low oxygen levels (1.5 mg/L) 0-2 hours post-fertilization (hpf) until three days post-fertilization (dpf), simulating the early stages of OD. Subsequent treatment involved varying concentrations of CA (1.25-5 µg/ml) up to nine days post-fertilization. The expression levels of BDNF and VGLUT1 were measured using PCR methods. Statistical analysis was conducted using Two-way ANOVA to evaluate the impact of CA on the expression of BDNF and VGLUT1 in zebrafish larvae aged 3 and 9 dpf in oxygen-deprived conditions. Results: CA significantly influenced the expression of BDNF and VGLUT1 under oxygen deprivation (p [Open Vet J 2024; 14(5.000): 1154-1160]

Pemanfaatan teknologi di era digital dapat meningkatkan pengetahuan peserta didik di dunia pendidikan. Salah satu media teknologi yang mendukung proses pembelajaran dengan memanfaatkan website atau Learning Managemen System (LMS) tanpa codingan dengan memanfaatkan google sites. Sebagai calon pendidik, mahasiswa prodi Pendidikan Agama Islam perlu memiliki kemmapuan dalam mengembangkan media pembelajaran yang interaktif, variatif dan menarik. Metode pelatihan yang dilakukan dalam penelitian ini yaitu ceramah, tanya jawab dan Latihan atau praktik. Hasil dari kegiatan pelatihan yang diikuti oleh 30 mahasiswa/i merupakan calon – calon SDM unggul yang mampu melakukan inovasi – inovasi dalam proses pembelajaran serta mewujudkan visi misi prodi Pendidikan Agama Islam sebagai salah satu Lembaga yang unggul dalam pendidikan dan mencetak tenaga – tenaga pendidik yang professional pendidikan yang melek akan teknologi. Para mahasiswa dapat memanfaatkan aplikasi google sites dalam proses pembuatan dan pemanfaatan media pembelajaran dan media Interaktif secara digital ataupun virtual. Pemanfaatan media interaktif google sites berbasis website sudah memadai. Selama praktik peserta/mahasiswa memiliki pemahaman yang cukup meningkat mengenai pemanfaatan teknologi berbasis website, sekitar 80% peserta mampu memahami dan melakukan praktik dengan baik dan benar.

Background: Hypoxia ischemia leads to abnormal behavior and growth. Prenatal hypoxia also decreases brain adaptive potential, which can cause fatal effects such as cell death. Asiatic acid in Centella asiatica is a neuroprotector through antioxidant and antiinflammatory activities. Aims: This study aimed to analyze the effect of Asiatic acid as a neuroprotector against hypoxia during intrauterine development on locomotor activity, head width, and BDNF expression. Methods: The true experimental laboratory research used a posttest control-only design. Zebrafish embryos (Danio rerio) aged 0-2 dpf (days postfertilization) were exposed to hypoxia with oxygen levels reaching 1.5 mg/L. Then, Asiatic acid was administered at successive concentrations, namely, 0.36 μg/ml, 0.72 μg/ml, and 1.45 μg/ml, at 2 hpf (hours postfertilization), 3 dpf, 6 dpf, and 9 dpf. Head width, velocity activity and BDNF expression were observed. Results: Intrauterine hypoxia significantly decreased head width, velocity rate, and BDNF expression ( [Open Vet J 2023; 13(10.000): 1326-1333]

Background & Aim: While virtual reality holds promise for enhancing patient management and experience during chemotherapy, its use remains limited. The present study aimed to test the feasibility, acceptability, and preliminary efficacy of smartphone-based virtual reality relaxation (SVR) in chemotherapy patients. Methods & Materials: In this pilot study, 29 participants were divided into two groups. The SVR group (n=14) experienced a 10-minute virtual reality intervention, while the control group (n=15) received standard care and guided imagery leaflets. Outcomes such as comfort, anxiety, pain, systolic blood pressure (SBP), diastolic blood pressure (DBP), and pulse rate were evaluated at baseline and post-chemotherapy. The Technology Acceptance Model (TAM) questionnaire and open-ended questions evaluated SVR’s acceptability. Data was analyzed using descriptive statistics, non-parametric t-tests, and thematic analysis. Results: The SVR intervention appears feasible, as evidenced by a high recruitment rate of 93.75% (30 out of 32 eligible patients) and a retention rate of 96.67% (29 out of 30 participants), despite one withdrawal. The SVR group showed significant comfort improvement (P=0.002), significant changes in pulse rate (P=0.047), and SBP (P=0.023) compared to the control group. Anxiety, pain, pulse rate, and DBP showed no significant differences. A significant TAM variable (P

BackgroundThe global obesity pandemic among adolescents is becoming a public health issue throughout the world. Telehealth use has significantly increased during and after the COVID-19 pandemic, including its application in adolescent obesity prevention and treatment. ObjectiveThis review aims to synthesize the evidence on the effectiveness of telenutrition in improving dietary behavior and physical activity in adolescents with obesity. MethodsThe PRISMA-P (Preferred Reporting Items for Systematic Reviews and Meta-Analysis Protocols) guideline will be used to structure this protocol. The focus of the systematic review is guided by the population, intervention, comparator, and outcome (PICO) framework. A systematic search of Science Direct, PubMed, Cochrane, Embase, JMIR, ProQuest, and Google scholar databases will be conducted. Two authors will screen the titles and abstracts of identified studies independently and select studies according to the eligibility criteria. The full-text reading will be done independently by 2 reviewers to assess final eligibility. Any discrepancies will then be discussed and resolved. The Cochrane Collaboration Risk of Bias tool was used to assess the risk of bias; a descriptive analysis will summarize the effectiveness of the telenutrition or any type of telehealth intervention used. ResultsThe systematic review is expected to be completed by the end of March 2024. The ongoing screening and review of the articles are currently being conducted. ConclusionsThis systematic review aims to summarize the effectiveness, features, design process, usability, and coherence of a telenutrition intervention using behavior change theory to improve dietary patterns and physical activity among adolescents with obesity. It will identify areas for improvement and best practices, informing the development of more useful and engaging telenutrition interventions for adolescents. Trial RegistrationPROSPERO CRD42023458336; http://tinyurl.com/cp46fjj9 International Registered Report Identifier (IRRID)DERR1-10.2196/53282

Objectives: The persistence in therapy of rheumatoid arthritis drugs and particularly bDMARD is a limiting factor for their long-term use. The randomized controlled trials (RCTs) may not reflect real-world contexts due to strict inclusion and exclusion criteria. Baricitinib, which targets both JAK1 and JAK2, has been used in Italy for several years. The aim of this multi-center study is to assess the real world persistence on therapy of baricitinib in RA patients and to identify predictive factors of baricitinib's survival rate. Methods: This is a retrospective, multicentric, Italian, longitudinal study. All patients were enrolled according to the following criteria: a) age ≥ 18 years old; b) diagnosed with RA according 2010 ACR/EULAR classification criteria; c) treated with baricitinib. In order to describe baricitinib clinical efficacy, the survival rate was evaluated by The Kaplan–Meier curve. Then, predictive factors of drug retention rate were assessed by performing the Cox analysis, identifying which risk factors influenced treatment persistence. Results: Overall, we included 478 patients treated with baricitinib. Among them, 380 (79.5%) were females. Baricitinib's survival rate was 94.6% at 6 months, 87.9% at 12 months, 81.7% at 24 months and 53.4% at 48 months. The Cox analysis regression showed that a higher bDMARDs/tsDMARD line of therapy seems to be a negative prognostic factor for the drug retention rate (HR 1.26 CI 95% 1.07–1.49, p = 0.006. Conclusion: Real-life study confirms baricitinib effectiveness up to 4 years, but previous treatment with bDMARDs was a negative prognostic factor for its survival rate.

Background: Hypoxia during pregnancy generates oxidative stress that alters the growth and development of the human fetus. Insulin-like growth factor-I (IGF-1) receptors are essential for normal fetal growth. Asiatic acid in Centella asiatica (CA) has antioxidant properties to prevent growth impairment in hypoxia. Aims: This study aimed to investigate the effect of asiatic acid on the morphological development of an intermittent hypoxia zebrafish embryo model and analyse molecular docking prediction in insulin-like growth factor-1 receptor (IGF-1R) signalling. Methods: Embryos of zebrafish at 2 hours postfertilization (hpf) were assigned to control negative (C), intermittent hypoxia (IH), and combination IH and CA extract groups consisting of 1.25 (IHCA1), 2.5 (IHCA2), and 5 (IHCA3) µg/ml. Hypoxia treatment (conducted 4 hours/day) and CA extract were administered for 3 days (2 - 72 hpf). The parameters of body length and head length were evaluated at 3, 6, and 9 days postfertilization (dpf). The data were analysed by a two-way ANOVA (P [Open Vet J 2023; 13(5.000): 629-637]

Dimasa pandemic Covid-19 berdampak terpuruknya kondisi ekonomi hamper di seluruh lini masyarakat, untuk itu kegiatan PKM Mono ini bertujuan untuk memberdayakan masyarakat dengan sharing pengetahuan dengan Teknik quilt menjadi produk yang bernilai jual. PKM Mono Semester Genap Th. Akademik 2021-2022 dengan Judul ‘Aplikasi Ondel-ondel Ikon Betawi menjadi Produk Baru dengan Teknik Quilt’ dilaksanakan pada minggu 27 Maret 2022 di RPTRA (Ruang Publik Terpadu Ramah Anak) Jati Bersinar, yang berada di Taman Ketang-ketang, Rawamangun, Kelurahan Jati, Kecamatan Pulogadung, Jakarta Timur dengan masyarakat Mitra adalah kelompok ibu-ibu Jumantik dari RT 01/RW 011. Diharapkan kegiatan ini menambah wawasan tentang pemanfaatan limbah perca untuk dapat dimanfaatkan Kembali menjadi produk baru dengan mengangkat lokal konten Ikon Betawi yaitu ‘Ondel-ondel’ dalam bentuk dekoratif dengan Teknik seni ‘Quilt’. Kegiatan ini nantinya dapat menjadi salah satu sumber pemasukkan bagi peserta Mitra dan juga dapat sebagai kegiatan bersosialisasi yang bermanfaat mengusung ekonomi kreatif kelompok ibu-ibu Jumantik untuk meningkatkan kesejahteraan bagi peserta Mitra yang juga ibu rumah tangga. Kegiatan PKM Mono ini juga merupakan program Tri Dharma Perguruan Tinggi yang dapat menjadi perpanjangan tangan Pemerintah daerah Wilayah Kelurahan Jati, Kecamatan Pulogadung, Jakarta Timur dan khususnya RT 01/ RW 011.

Berbagai upaya telah dilakukan untuk meningkatkan perekonomian masyarakat khususnya bagi mereka yang berpenghasilan di bawah UMR (Upah Minimum Regional). Salah satu upaya tersebut adalah memberikan pelatihan untuk meningkatkan keterampilan masyarakat, yang pada akhirnya diharapkan dapat menjadi sumber lapangan usaha baru. Dalam kesempatan kali ini, Program Studi Desain Produk FSRD Universitas Trisakti, melaksanakan pelatihan melalui kegiatan Pengabdian kepada Masyarakat (PkM) dengan tema pembuatan peralatan rumah tangga dari kayu bekas. Kayu bekas merupakan sumber daya material yang murah dan banyak dijumpai, yaitu berasal dari kayu sisa pabrik mebel, furniture, dan peti kemas. Masyarakat yang menjadi sasaran kegiatan adalah pemuda Karang Taruna dari RT 008, RW 004, Kelurahan Gunung, Kecamatan Kebayoran Baru, Jakarta Selatan. Kegiatan ini bertujuan memberikan pengetahuan dan keterampilan dalam mengolah kayu bekas menjadi produk fungsional dan bernilai ekonomi. Metode eksperimen dilakukan pada tahap persiapan, dilanjutkan dengan metode partisipatori dan pendampingan pada pelaksanaan pelatihan. Melalui pelatihan ini, para peserta menguasai keterampilan dalam membuat produk-produk berbahan kayu bekas. Hasil PkM berupa produk fungsional seperti: wadah serba guna, rak bumbu, tempat tisu, nampan, dan alas gelas, diharapkan dapat dikembangkan sebagai peluang usaha untuk meningkatkan penghasilan.

Abstract Background and Aims Children admitted in the pediatric intensive care unit (PICU) often deal with long‐term morbidities affecting physical, cognitive, emotional, social, and psychiatric symptoms. We aimed to identify the internal and external factors which predict the occurrence of neurocognitive and psychological disorders in survivors at 3 months after PICU discharge. Methods We identified 53 critically ill children, ages 4–18 years old, admitted in PICU for more than 24 h, and survived. We evaluated neurocognitive disorder with Pediatric Cerebral Perfomance Category (PCPC) and psychological disorders with Strengths and Difficulties Questionnaire (SDQ) at the time of PICU discharge and repeated in 3 months afterward. We evaluated the internal and external risk factors related to neurocognitive and psychological disorders in PICU survivors. The internal risk factors were age, gender, family composition, and socioeconomic status. The external risk factors were: surgical intervention, neurological disease, predicted death rate by pediatric index mortality (PIM)‐2 score, PICU length of stay (LOS), days of mechanical ventilation, and the number of therapeutic interventions. Results There were significant improvement in neurocognitive disorders (p < 0.001), peer problems, (p = 0.01), and prosocial behaviors (p = 0.00) in children at 3 months after the PICU discharge. Age of 4–5 years has a significant effect on neurocognitive disorders (p = 0.04), while male gender (p = 0.02), low‐social economy, non‐intact family composition (p = 0.01), neurological disease (p = 0.04), surgical intervention (p = 0.01), and TISS score (p = 0.00) have a significant effect on psychological disorders in children at 3 months after the PICU discharge Conclusion Neurocognitive disorders, peer problems, and prosocial behaviors improved in a few patients 3 months after PICU discharge. Age of 4–5 years was a risk factor of the persisted neurocognitive disorder, whereas male gender, low‐social economy, non‐intact family composition, neurological disease, surgical intervention, and TISS score were risk factors of persisted psychological disorder at 3 months after PICU.

Objective To describe demographic, clinical and laboratory features of systemic sclerosis sine scleroderma (ssSSc) in a large multicentre systemic sclerosis (SSc) cohort.Methods Data involving 1808 SSc patients from Italian Systemic sclerosis PRogression INvestiGation registry were collected. The ssSSc was defined by the absence of any cutaneous sclerosis and/or puffy fingers. Clinical and serological features of ssSSc were compared with limited cutaneous (lcSSc) and diffuse cutaneous (dcSSc) subsets.Results Among patients with SSc, only 61 (3.4%) were classified as having ssSSc (F/M=19/1). Time from Raynaud’s phenomenon (RP) onset to diagnosis was longer in ssSSc (3 years, IQR 1–16.5) than lcSSc (2 years, IQR 0–7), and dcSSc (1 year, IQR 0–3) (p

This study aimed to know the quality of undergraduate students' teaching competencies as teacher candidates. The subjects of this study were 54 teachers of 32 vocational schools. The data was obtained from the Educational Practice Program (EPP) in Vocational High School (VHS) using online questionnaires via Google Form. This study used a quantitative descriptive approach with survey research. Data were analyzed using normality tests and product-moment correlation analysis. The results indicated that the undergraduate students' competencies as candidate teachers were more dominant in social competency than personal, pedagogical, and professional competencies. Each competency had a highly strong relationship with others so that there was a significant attachment. Therefore, the undergraduate students as candidate teachers need to develop competencies to improve their quality in EPP. Abstrak: Penelitian ini bertujuan untuk mengetahui kualitas kompetensi mengajar mahasiswa sebagai calon guru. Subyek penelitian ini adalah 54 guru dari 32 Sekolah Menengah Kejuruan (SMK). Data diperoleh dari mata pelajaran pada Program Praktek Pendidikan di Sekolah Menengah Kejuruan (SMK) dengan menggunakan angket melalui Google Form. Penelitian ini menggunakan pendekatan deskriptif kuantitatif dengan jenis penelitian survey. Data dianalisis menggunakan uji normalitas dan analisis korelasi product moment. Hasil penelitian menunjukkan bahwa kompetensi mahasiswa sebagai calon guru lebih dominan pada kompetensi sosial dibandingkan kompetensi kepribadian, pedagogik, dan profesional. Setiap kompetensi memiliki hubungan yang sangat kuat dengan yang lain sehingga terjadi keterikatan yang signifikan. Oleh karena itu, mahasiswa sebagai calon guru perlu meningkatkan kompetensi untuk meningkatkan kualitasnya di EPP.

Salah satu contoh konkrit untuk mengurangi sampah plastik adalah dengan memanfaatkan mainan plastik bekas menjadi elemen estetis pada produk. Melalui program Pengabdian kepada Masyarakat yang diadakan oleh Program Studi Desain Produk Fakultas Seni Rupa dan Desain Universitas Trisakti, kegiatan yang bersifat edukatif tentang penanganan sampah plastik ini dilaksanakan dengan masyarakat sasaran 15 orang ibu-ibu PKK di Kelurahan Angke, Kecamatan Tambora, Jakarta Barat. Selain bertujuan untuk mengedukasi masyarakat agar peduli pada penanganan sampah plastik, kegiatan ini juga menjadi media untuk merangsang kreativitas masyarakat dalam mengolah barang bekas menjadi produk baru yang bernilai jual. Metode eksperimen dilakukan pada tahap persiapan sebagai upaya untuk memecahkan masalah berkaitan dengan pengolahan limbah kayu dan barang bekas yang dipadukan dengan limbah plastik sebagai elemen estetisnya. Pada tahap pelaksanaan, metode pelatihan dilakukan dengan demonstrasi oleh instruktur PkM yang dilanjutkan dengan praktik oleh para peserta. Para instruktur memberikan pendampingan pada setiap tahap dalam pelatihan ini. Melalui kegiatan ini telah dihasilkan 12 produk berupa stoples, gantungan baju, cermin, dan tempat gantungan kunci.

Botol bekas berbahan dasar kaca merupakan limbah yang dihasilkan dari penggunaan bahan makanan seperti kecap, saus, dan minuman. Untuk memperpanjang nilai guna limbah botol kaca, perlu dilakukan pengembangan bentuk produk melalui metode upcycling sehingga dapat memperpanjang usia guna limbah botol kaca yaitu dengan memanfaatkan limbah botol kaca tersebut menjadi lampu meja melalui pelatihan kepada masyarakat khususnya generasi muda. Pelatihan untuk pengembangan bentuk lampu meja dari limbah botol kaca ini dilakukan melalui kegiatan Pengabdian kepada Masyarakat dari Fakultas Seni Rupa dan Desain Universitas Trisakti dengan sasaran masyarakat Kelurahan Kebon Baru, Kecamatan Tebet, Jakarta Selatan. Tujuannya adalah untuk meningkatkan kreativitas dan produktivitas masyarakat serta meningkatkan peluang pendapatan masyarakat di masa pandemi COVID-19 ini. Hasil dari pelatihan ini adalah pengembangan bentuk produk lampu meja berupa 3 model lampu meja dari limbah botol kaca dapat dibuat oleh masyarakat sasaran.

Sejalan dengan sistem pendidikan dalam memasuki era revolusi 4.0 dan keterampilan abad 21, salah satu kompetensi yang perlu dikuasai oleh peserta didik adalah kemampuan berkomunikasi. Berpresentasi merupakan salah satu bentuk komunikasi untuk menyampaikan pemikiran, gagasan, pengetahuan, ataupun informasi secara efektif. Pada masa pandemi ini, seluruh proses belajar mengajar dilaksanakan secara daring, sehingga kemampuan untuk melakukan presentasi di ruang virtual juga diperlukan. Berdasarkan hal tersebut, tim Pengabdian kepada Masyarakat (PkM) mengadakan kegiatan pelatihan bertema Peningkatan Kemampuan Berpresentasi di Ruang Virtual, dengan sasaran siswa siswi SMA Sumbangsih, Jakarta Selatan. Kegiatan PkM dilaksanakan secara daring melalui media zoom meeting mengingat kondisi pada masa pandemi covid-19 tidak memungkinkan untuk mengadakan kegiatan yang bersifat luring. Tujuan dari kegiatan ini adalah meningkatkan kemampuan siswa siswi dalam melakukan presentasi yang efektif, komunikatif, dan interaktif di dalam ruang virtual. Materi yang diberikan meliputi keterampilan mengoperasikan fitur-fitur berpresentasi di ruang meeting virtual, pengantar teoritis bagaimana menjadi presenter yang komunikatif dan percaya diri, dan pemberian contoh berpresentasi. Metode yang diterapkan dalam kegiatan ini adalah metode demonstrasi (memberi contoh) yang disampaikan oleh 2 orang mahasiswa FSRD. Keterlibatan mahasiswa dalam hal ini adalah sebagai upaya untuk menemukan pendekatan dalam memancing respon dari para peserta. Selanjutnya beberapa orang siswa diminta untuk mempraktikkan materi yang telah diberikan dengan melakukan presentasi secara spontan. Hasil kegiatan menunjukkan bahwa kemampuan siswa siswi dalam melakukan presentasi secara non formal sudah cukup baik namun pada teknik presentasi secara formal masih harus belajar dalam bertutur kata menggunakan bahasa baku dan ilmiah. Kata kunci: kemampuan berpresentasi, ruang virtual, pengabdian kepada masyarakat, pelatihan, SMA Sumbangsih

Terpuruknya kondisi ekonomi di Indonesia akibat pandemi covid-19 telah berdampak pada semua lapisan masyarakat. Berbagai upaya dilakukan untuk memberdayakan masyarakat, salah satunya melalui kegiatan Pengabdian kepada Masyarakat (PkM). Tema yang diangkat dalam kegiatan kali ini adalah pengaplikasian desain mosaik pada produk rumah tangga sebagai peluang usaha baru bagi masyarakat terdampak pandemi Covid-19, dengan sasaran masyarakat yang bekerja sebagai pengemudi ojek, tukang las, dan pekerja bangunan. Kegiatan ini bertujuan memberikan pengetahuan dan keterampilan tentang pengaplikasian mosaik dari pecahan kaca dan keramik yang dikombinasikan dengan kayu bekas peti kemas menjadi produk nampan. Metode eksperimen dilakukan pada tahap persiapan, dilanjutkan dengan metode participatory action research dan pendampingan pada pelaksanaan pelatihan. Melalui pelatihan ini, para peserta menguasai keterampilan dalam membuat nampan kayu dan memiliki pemahaman estetika dalam menyusun pecahan kaca dan keramik menjadi mosaik. Hasil PkM berupa produk nampan yang fungsional dan bernilai estetis diharapkan dapat membuka peluang usaha baru bagi para peserta.

Remaja Karang Taruna Cikoko Timur RW 02 has several routine activities, one of which is traditional Betawi dance. Based on the survey results, it is known that one of the obstacles faced is the limited funds to rent dancing equipment if you are going to appear in a show. Based on this, the Trisakti University FSRD Community Service team decided to provide training in making headdresses and masks using cheap and easily available materials. The training was carried out by giving examples (demonstrations) by the instructor and continued with practice by the participants accompanied by the PkM instructor team. The results of the training were in the form of a headdress made of chicken feathers and equipped with a mask as self-protection so that you could dance during the pandemic. Knowledge of the design and application of independently produced headdresses and face masks not only saves costs, but also hones the skills and creativity of youth of Karang Taruna. Furthermore, if it is seriously developed it will open up new business opportunities for the youth of the Youth Organization. Remaja Karang Taruna Cikoko Timur RW 02 memiliki beberapa kegiatan rutin salah satunya adalah menari tradisional Betawi. Berdasarkan hasil survei, diketahui bahwa salah satu kendala yang dihadapi adalah keterbatasan dana untuk menyewa perlengkapan menari jika akan tampil dalam sebuah pertunjukan. Berdasarkan hal tersebut, tim Pengabdian kepada Masyarakat FSRD Universitas Trisakti memutuskan untuk memberikan pelatihan pembuatan hiasan kepala dan masker dengan menggunakan material yang murah dan mudah diperoleh. Pelatihan dilakukan dengan memberikan contoh (demonstrasi) oleh instruktur dan dilanjutkan dengan praktik oleh para peserta didampingi oleh tim instruktur PkM. Hasil pelatihan berupa hiasan kepala berbahan baku utama bulu ayam dan dilengkapi dengan masker sebagai proteksi diri agar tetap dapat menari selama pandemi. Pengetahuan tentang desain dan penerapannya pada hiasan kepala dan masker wajah yang diproduksi secara mandiri tidak hanya menghemat biaya, namun juga mengasah keterampilan dan kreativitas remaja Karang Taruna. Lebih jauh lagi, jika dikembangkan secara serius akan membuka peluang usaha baru bagi remaja Karang Taruna tersebut.

Objective: Self-empowerment is an important factor that influences a person's ability to perform effective diabetes management. One effort that can be done to improve self-empowerment is by providing a smartphone-based online peer-group. This research determined the effect of smartphone-based online peer groups on type 2 diabetes mellitus (T2DM) patients self-empowerment in four primary healthcare centers in Indonesia. Methods: This quasi-experimental research was conducted in four healthcare centers in Indonesia. The total sample was 71 divided into two groups (control and intervention). The control group received standard education from the healthcare center, whereas the intervention group underwent an online peer-group. Self-empowerment was measured before and after intervention using the Diabetes Empowerment Scale-Short Form (DES-SF) questionnaire (Indonesian version). General Linear Model was used in statistical analysis. Results: The mean age of respondents was 56.4 ± 8.8 and 56.9 ± 7.1 years old, 59.5%, and 76.5% had good family support, and 70.3% and 50% of respondents had not received diabetes education for the control and intervention groups, respectively. The average pretest self-empowerment score was 27.03 ± 3.73 and 27.59 ± 3.53 (diff. 0.56; 95%CI -1.16; 2.29), and the post-test score was 27.43 ± 4.13 and 32.76 ± 4.38 (diff. 5.33; 95%CI 3.32; 7.35) for the control and intervention groups, respectively. Online peer-group improve self-empowerment significantly in the intervention group. Conclusion: Smartphone-based online peer-group can improve self-empowerment in patients with T2DM.

The number of patients with diabetes in Indonesia reach 19,47 million in 2021, mostly is caused by the adoption of sedentary and unhealthy lifestyles. Continuous self-management is important in diabetes care. It requires optimal coordination and communication between patients, families, and health care provider. The use of communication technology could be solution to the problem. This study aims to initiate an android-based mobile apps technology as a tool for patient, family, and healthcare provider to optimize patient with T2DM treatment. This study will be conducted in Public Health Centers (PHCs) in Yogyakarta using an exploratory sequential mixed-methods design which is divided into three phases. The first phase will use qualitative descriptive methods. Patients with T2DM, families, nurses, physicians and Health Social Security Agency officers in Indonesia will be involved in a focus group discussion (FGD) and in-depth interviews to understand their needs in optimizing the treatment. The second phase will be the development of an android-based application on the first phase results. The apps will be usability tested by involving experts (heuristic evaluation) and users (think aloud method) to ensure that the apps really meet targeted user's need. In the third phase, we will collect feedback from user after using this apps for three months. The effectiveness of the apps will be measured by self-management improvement and glycemic control of patients with T2DM. The non-equivalent control group design will be applied using a pre-repeated post-test control group. The result of this study will be an Android-based Application which will be called Integrated Diabetes Self-Management (IDSM) app to optimize the implementation of diabetes self-management which can improve glycemic control of patients with T2DM as one of the indicators of the Indonesian Chronic Disease Management Program at PHCs.

Background: Drug resistance and multi drugs tuberculosis (DR/MDR-TB) are associated with patients' low adherence to undergoing complex treatment. Driven by the increasing use and penetration of a smartphone and the End of TB Strategy that seeks for digital health solution, Center for Tropical Medicine Universitas Gadjah Mada has developed TOMO, an Android-based app for improving medication adherence in MDR-TB. Objective: This paper aims to present the sequential steps to develop the app, its general architecture, and its functionalities. Methods: It is a design thinking process involving two MDR-TB referral centers, district health offices, primary health centers, and MDR-TB patients in Central Java and Yogyakarta, Indonesia. We adopted the Principles for Digital Development to develop and design the app. MDR-TB treatment guideline from the Indonesian Ministry of Health was used to develop functionalities of the app for improving adherence. Results: TOMO app could be used by patients, primary health centers, clinical teams, and case managers. The app prototype features include adverse event records and reports, medication-taking reminders, and communication between the patient and the TB-MDR case manager. We have successfully tested the functionalities based on four use cases: patients with high adherence, patients with low adherence, patients with adverse events, and patients following treatment in the primary health center without any visit to the MDR-TB center. Conclusion: TOMO app has contributed to the limited body of literature on improving TB-MDR adherence with digital health intervention, especially using a health app. The app has been tested using four scenarios. We will follow up with usability testing before implementing the app in a real setting.

Atualmente, as redes sociais são um meio de se expressar; poucas pessoas as tinham, contudo isso mudou e, hoje em dia, elas se tornaram uma exigência, sendo utilizadas até mesmo pelas empresas e se tornando um diferencial competitivo. O objetivo do estudo é analisar como as redes sociais influenciam o comportamento e atitude de compra dos universitários de uma instituição pública e outra privada. Foi realizado por meio de uma pesquisa bibliográfica, sendo classificada, quanto à metodologia utilizada, como um estudo quantitativo, mediante amostragem não probabilística e por cotas em duas instituições de ensino superior, uma pública e outra particular, com 100 universitários. Os principais achados indicam que 70% dos acadêmicos concordam que as redes sociais facilitam o contato com o produto; da mesma forma, 70% consideram importante que as empresas tenham redes sociais. Por outro lado, 49% concordam que as redes sociais influenciam na hora da compra e para 47% as lojas oferecem facilidades de vendas por meio delas. Muito embora, a segurança oferecida pelas redes sociais tenha apenas 29% de aprovação e 15% somente acreditem que a qualidade do produto é a mesma que a descrita nas redes sociais. Por fim, entre as redes sociais mais utilizadas para compra aparecem o Whatsapp (48%), o Facebook (34%) e o Instagram (14%). Como contribuição, foi possível entender o comportamento dos acadêmicos, que se trata de um público jovem e mais conectado, o que pode ajudar as organizações a criarem estratégias específicas de acordo com a característica desse grupo.

Pornography has big negative impacts on students. KALIGRAFI has purpose to reduce the negative impact of pornography and develop potential motoric on children. This program implemented for 5 months at Karangbesuki 1 Elementary School Malang. The methods used are pretest, giving material, integrated practice, and posttest. Materials given are religious and sexual education and also healthy internet usage. Integrated exercise is done through fun games and grouping of children based on talents and interests to increase the potential of children. The results show that there is a decrease in the number of students exposed to the negative effect of pornography from 57.5% to 17.5% of students. Based on the results, KALIGRAFI make some regeneration and modules as sustainability of the program so that the program can be maintained and even can be applied easily by the community from elementary school students, educators and parents

Background : Sago worm flour (Rhyinchophorus ferrugineus)is a coconut beetle larvae that is processed into flour.This flour contains antioxidants as well as arginine, both of which play a role in modulating oxidative stress including NO involved in immunopathology of cerebral malaria.Objectives : To prove the immunomodulator role of sago worm flour in decreasing circulation NO level at mice who received standard antimalarial therapy Dihydroartemisinin Piperaquine (DHP)Methods : This study was randomized control group post test only design by using 23 Swiss mice which divided into 5 group consist of : K(-) normal mice; K(+) inoculated woth Plasmodium berghei ANKA (PbA); X1 received DHP; X2 received sago worm flour; X3 received both of sago worm flour and DHP. All treatment groups X1,X2 and X3 were inoculated by PbA before treatmen were given. Serum circulation NO level was assessed by ELISA. statistical analysis used was One Way ANOVA followed by Bonferroni post hoc test. Results : The mean NO level in K(-), K(+), X1, X2, and X3 were 1.008 μmol/mL, K(+) 1.338 μmol/mL; while at treatment X1 1.143 μmol/mL, X2 1.410 μmol/mL, dan X3 0.886 μmol/mL. One way ANOVA showed that they were significantly different (p=0.001). Bonferroni post hoc test of X2 was proportional to K(+) (p=1.000), whole had NO level lower than either K(+)(p=0.009) or X2 (p=0.002). Conclusion : The immunomodulatory effects of sago worm flour (Rhyinchophorus ferrugineus) reduced circulating NO levels in standard antimalarial therapy recipients.

Penelitian ini bertujuan untuk menganalisis pembobotan Key performance Indicator dengan model SCOR menggunakan metode Analitical Hierarchy Process (AHP) produk keju mozzarella di CV Brawijaya Dairy Industry. Hasil penelitian di peroleh 36 Key Performance Indicator yang disesuikan dengan model SCOR yaitu plan, source, deliver, make (process), dan return. Hasil pembobotan dengan menggunakan pembobotan AHP pada hierarki tingkat 1 yang memiliki bobot tertinggi adalah make (process) dengan nilai bobot 0,534. Hal ini dikarenakan perusahaan mementingkan kualitas produk yang dipengaruhi oleh proses produksi. Pada hierarki tingkat 2 bobot tertinggi terdapat pada variabel reliability dengan total bobot 0,739. Sedangkan nilai bobot tertinggi pada hierarki tingkat 3 (Key Performance Indicator) adalah pada KPI 24 Kehandalan kinerja karyawan dalam mengolah menjadi produk jadi dengan total bobot 0,180.

Latar belakang. Faktor yang memengaruhi pemberian ASI eksklusif pada ibu bekerja adalah pengetahuan, sikap, dan dukungan institusi. Petugas kesehatan berperan ganda, yaitu sebagai ibu bekerja dan panutan praktek pemberian ASI. Tujuan. Memperoleh hubungan antara pengetahuan, sikap, dukungan unit kerja terhadap praktek pemberian ASI eksklusif oleh tenaga kesehatan di Rumah Sakit Umum Dr. Hasan Sadikin (RSHS). Metode. Penelitian cross-sectional dengan metode consecutive sampling, dilakukan pada bulan Januari-Maret 2016 pada peserta program pendidikan dokter spesialis (PPDS), peserta program pendidikan profesi dokter (PSPD), perawat, dan bidan wanita; berusia ≤37 tahun; bekerja atau belajar di RSHS; memiliki anak lahir tunggal berusia 6−24 bulan; mengisi kuesioner dan dianalisis dengan multivariat Hasil. Pengetahuan (OR IK95%=3,7; p=0,013) dan dukungan tenaga kesehatan (OR IK95%=3,45; p=0,031) berhubungan dengan praktek pemberian ASI eksklusif. Kesimpulan. Pengetahuan ibu berhubungan dengan praktek pemberian ASI eksklusif, sementara dukungan unit kerja/departemen dan sikap tidak berhubungan dengan hal itu. Dukungan petugas kesehatan merupakan faktor perancu yang berhubungan dengan hal tersebut.

The integration of blockchain technology in stamp duty administration requires a clear legal framework to ensure effective implementation. This study evaluates the benefits and challenges of using blockchain in stamp duty imposition and provides regulatory framework recommendations. Using a normative legal approach and analysis of relevant legislation, the research shows that blockchain can significantly enhance efficiency, transparency, and security in the stamp duty process. The immutable nature of blockchain records ensures data integrity and reduces the risk of fraud. Moreover, smart contracts can automate and streamline the transaction process, minimizing human error. However, the adoption of blockchain faces challenges such as high initial costs and the need for regulatory adjustments. In conclusion, the adoption of blockchain in stamp duty administration necessitates comprehensive regulations to ensure the legality and validity of recorded transactions, providing a robust and reliable tax system for the digital age.

Character education is urgent in passing down the ethical and moral values in the cultured community life. The local cultural values are a source of ethics and moral education for elementary school students. The school keeps taking an essential role in cultivating the local values through online character education during the COVID-19 pandemic. This study aimed to analyze the effect of implementing online integrated character education and parental engagement in local cultural values cultivation outcome. The method of this study used an exploratory sequential mixed method design. Collect qualitative data using interview forms, observation, documentation, and quantitative data using questionnaires and portfolios. Qualitative data interpretation used content analysis, and inferential analysis used multiple linear regression. Results revealed that parental engagement, teachers' performance, and online learning obstacles affect local cultural values cultivation outcome in character education partially and simultaneously for sixth-grade students in Padang City. We suggested teachers improve character education management based on local cultural values by building good synergy and collaboration between them and parents to cultivate noble character behavior among students.