1. Crystallization at Solvent Interfaces Enables Access to a Variety of Cocrystal Polymorphs and Hydrates
- Author
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Stefan J. Diez, William Jones, Mark D. Eddleston, Andrew D. Bond, Marie Milbled, Dejan-Krešimir Bučar, Mihails Arhangelskis, Matthias J. Müller, Arhangelskis, M [0000-0003-1150-3108], Bond, AD [0000-0002-1744-0489], Bučar, DK [0000-0001-6393-276X], and Apollo - University of Cambridge Repository
- Subjects
Materials science ,34 Chemical Sciences ,Crystal growth ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,01 natural sciences ,Cocrystal ,0104 chemical sciences ,law.invention ,Crystal ,Solvent ,3402 Inorganic Chemistry ,Chemical engineering ,law ,General Materials Science ,Crystallization ,0210 nano-technology - Abstract
A crystal growth technique, interfacial cocrystallization, is demonstrated to be a simple and effective method for preparing multicomponent crystal forms. The technique is based on the generation of a liquid–liquid interface between two immiscible solutions of cocrystal-forming compounds, and its utility is demonstrated through the preparation of polymorphs and hydrates of caffeine cocrystals, involving three different hydroxy-2-naphthoic acids, including the formation of some with unexpected compositions.
- Published
- 2018