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1,200 results on '"Argilés, Josep M."'

2. Formoterol reduces muscle wasting in mice undergoing doxorubicin chemotherapy

Author

Lima Junior, Edson Alves de, primary, Teixeira, Alexandre Abilio de Souza, additional, Silveira, Loreana Sanches, additional, Jové, Queralt, additional, Ladrón, Natalia Álvarez, additional, Pereira, Marcelo G., additional, López-Soriano, Francisco Javier, additional, Argilés, Josep M., additional, Brum, Patrícia Chakur, additional, Busquets, Silvia, additional, and Neto, José Cesar Rosa, additional

Published
2024
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8. Formoterol reduces muscle wasting in mice undergoing doxorubicin chemotherapy.

Author

Alves de Lima Junior, Edson, Abilio de Souza Teixeira, Alexandre, Silveira, Loreana Sanches, Jové, Queralt, Ladrón, Natalia Álvarez, Pereira, Marcelo G., López-Soriano, Francisco Javier, Argilés, Josep M., Brum, Patrícia Chakur, Busquets, Silvia, and Neto, José Cesar Rosa

Subjects
FORMOTEROL, DOXORUBICIN, CANCER chemotherapy, WEIGHT loss, PROGNOSIS, SOLEUS muscle
Abstract

Background: Even though doxorubicin (DOX) chemotherapy promotes intense muscle wasting, this drug is still widely used in clinical practice due to its remarkable efficiency in managing cancer. On the other hand, intense muscle loss during the oncological treatment is considered a bad prognosis for the disease's evolution and the patient's quality of life. In this sense, strategies that can counteract the muscle wasting induced by DOX are essential. In this study, we evaluated the effectiveness of formoterol (FOR), a β2-adrenoceptor agonist, in managing muscle wasting caused by DOX. Methods and results: To evaluate the effect of FOR on DOX-induced muscle wasting, mice were treated with DOX (2.5 mg/kg b.w., i.p. administration, twice a week), associated or not to FOR treatment (1 mg/kg b. w., s.c. administration, daily). Control mice received vehicle solution. A combination of FOR treatment with DOX protected against the loss of body weight (p<0.05), muscle mass (p<0.001), and grip force (p<0.001) promoted by chemotherapy. FOR also attenuated muscle wasting (p<0.01) in tumor-bearing mice on chemotherapy. The potential mechanism by which FOR prevented further DOX-induced muscle wasting occurred by regulating Akt/FoxO3a signaling and gene expression of atrogenes in skeletal muscle. Conclusions: Collectively, our results suggest that FOR can be used as a pharmacological strategy for managing muscle wasting induced by DOX. This study provides new insights into the potential therapeutic use of FOR to improve the overall wellbeing of cancer patients undergoing DOX chemotherapy. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Interleukin-15 stimulates adiponectin secretion by 3T3-L1 adipocytes: evidence for a skeletal muscle-to-fat signaling pathway.

Author

Quinn, Lebris S, Strait-Bodey, Lena, Anderson, Barbara G, Argilés, Josep M, and Havel, Peter J

Subjects
Muscle, Skeletal, Cells, Cultured, 3T3-L1 Cells, Adipocytes, Animals, Mice, Rats, Interleukin-15, Signal Transduction, Adiponectin, interleukin-15, adipocyles, skeletal muscle, adiponectin, cytokines, Muscle, Skeletal, Cells, Cultured, Biochemistry and Cell Biology, Biochemistry & Molecular Biology
Abstract

Interleukin-15 (IL-15) is a cytokine which is highly expressed in skeletal muscle tissue, and which has anabolic effects on skeletal muscle protein dynamics both in vivo and in vitro. Additionally, administration of IL-15 to rats and mice inhibits white adipose tissue deposition. To determine if the action of IL-15 on adipose tissue is direct, the capacity of cultured murine 3T3-L1 preadipocytes and adipocytes to respond to IL-15 was examined. IL-15 administration inhibited lipid accumulation in differentiating 3T3-L1 preadipocytes, and stimulated secretion of the adipocyte-specific hormone adiponectin by differentiated 3T3-L1 adipocytes. The latter observation constitutes the first report of a cytokine or growth factor which stimulates adiponectin production. IL-15 mRNA expression by cultured 3T3-L1 adipogenic cells and C2C12 murine skeletal myogenic cells was also examined. Quantitative real-time PCR indicated IL-15 mRNA was expressed by C2C12 skeletal myogenic cells, and was upregulated more than 10-fold in differentiated skeletal myotubes compared to undifferentiated myoblasts. In contrast, 3T3-L1 cells expressed little or no IL-15 mRNA at either the undifferentiated preadipocyte or differentiated adipocyte stages. These findings provide support for the hypothesis that IL-15 functions in a muscle-to-fat endocrine axis which modulates fat:lean body composition and insulin sensitivity.

Published
2005

12. Recent Developments in Treatment of Cachexia

Author

Argilés, Josep M., López-Soriano, Francisco Javier, Stemmler, Britta, Busquets, Sílvia, Crommelin, Daan J. A., Editor-in-chief, Lipper, Robert A., Editor-in-chief, Folkerts, Gert, editor, and Garssen, Johan, editor

Published
2014
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15. Prevalence of Cachexia in Cancer Patients

Author

Orellana López, Cristian, Leyton Estéfane, Jose, Ramos Rosales, Miguel, Vásquez Ramirez, Claudio, Manriquez Arriagada, Claudia, Argilés, Josep M., López-Soriano, Francisco J., Ortega González, Francisco, Yañez, Nicolás, and Busquets, Silvia

Abstract

Introduction. Cachexia is a syndrome characterized by the loss of musculoskeletal mass, with or without adipose mass, which cannot be reversed by nutritional support. In Chile, there are no data on cachexia in cancer patients that allows for decision making on better interdisciplinary management. In this study, the prevalence of cachexia in inpatient and outpatient cancer patients was investigated. Methods. An observational, descriptive, and cross-sectional study was carried out. Eighty-six inpatients and outpatients were evaluated. Cachexia was evaluated by applying the miniCASCO tool, its weight by bioimpedance, and inflammation by blood parameters. Comparisons and correlations were made considering p

Published
2023
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18. The Role of Cytokines in Cancer Cachexia

Author

Argilés, Josep M., Busquets, Sílvia, Moore-Carrasco, Rodrigo, López-Soriano, Francisco J., Mantovani, Giovanni, editor, Anker, Stefan D., editor, Inui, Akio, editor, Morley, John E., editor, Fanelli, Filippo Rossi, editor, Scevola, Daniele, editor, Schuster, Michael W., editor, and Yeh, Shing-Shing, editor

Published
2006
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19. Cancer Cachexia and Fat Metabolism

Author

Argilés, Josep M., Almendro, Vanessa, Busquets, Sílvia, López-Soriano, Francisco J., Mantovani, Giovanni, editor, Anker, Stefan D., editor, Inui, Akio, editor, Morley, John E., editor, Fanelli, Filippo Rossi, editor, Scevola, Daniele, editor, Schuster, Michael W., editor, and Yeh, Shing-Shing, editor

Published
2006
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20. Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue: In Vivo and In Vitro Studies

Author

Wang, Lei, van Iersel, Lieke E J, Pelgrim, Charlotte E, Lu, Jingyi, van Ark, Ingrid, Leusink-Muis, Thea, Gosker, Harry R, Langen, Ramon C J, Schols, Annemie M W J, Argilés, Josep M, van Helvoort, Ardy, Kraneveld, Aletta D, Garssen, Johan, Henricks, Paul A J, Folkerts, Gert, Braber, Saskia, Afd Pharmacology, Pharmacology, Pulmonologie, RS: NUTRIM - R3 - Respiratory & Age-related Health, Fac. Health, Medicine and Life Sciences, Bedrijfsbureau NTM, Afd Pharmacology, and Pharmacology

Subjects
Adipose Tissue/metabolism, Interleukin-1beta, Skeletal/metabolism, Biochemistry, cachexia, Cigarette Smoking, Mice, Smoke/adverse effects, Smoke, COPD, Animals, skeletal muscle, Muscle, Skeletal, Tumor Necrosis Factor-alpha/metabolism, Muscle, Skeletal/metabolism, Tumor Necrosis Factor-alpha, Biochemistry, Genetics and Molecular Biology(all), cigarette smoke, Fatty Acids, Cytokines/metabolism, General Medicine, adipose tissue, lipolysis, Fatty Acids/metabolism, Adipose Tissue, Interleukin-1beta/metabolism, Muscle, Cytokines, Genetics and Molecular Biology(all)
Abstract

Chronic obstructive pulmonary disease (COPD), often caused by smoking, is a chronic lung disease with systemic manifestations including metabolic comorbidities. This study investigates adaptive and pathological alterations in adipose and skeletal muscle tissue following cigarette smoke exposure using in vivo and in vitro models. Mice were exposed to cigarette smoke or air for 72 days and the pre-adipose cell line 3T3-L1 was utilized as an in vitro model. Cigarette smoke exposure decreased body weight, and the proportional loss in fat mass was more pronounced than the lean mass loss. Cigarette smoke exposure reduced adipocyte size and increased adipocyte numbers. Adipose macrophage numbers and associated cytokine levels, including interleukin-1β, interleukine-6 and tumor necrosis factor-α were elevated in smoke-exposed mice. Muscle strength and protein synthesis signaling were decreased after smoke exposure; however, muscle mass was not changed. In vitro studies demonstrated that lipolysis and fatty acid oxidation were upregulated in cigarette smoke-exposed pre-adipocytes. In conclusion, cigarette smoke exposure induces a loss of whole-body fat mass and adipose atrophy, which is likely due to enhanced lipolysis.

Published
2022

24. Central Melanin-Concentrating Hormone Influences Liver and Adipose Metabolism Via Specific Hypothalamic Nuclei and Efferent Autonomic/JNK1 Pathways

Author

Imbernon, Monica, Beiroa, Daniel, Vázquez, María J., Morgan, Donald A., Veyrat–Durebex, Christelle, Porteiro, Begoña, Díaz–Arteaga, Adenis, Senra, Ana, Busquets, Silvia, Velásquez, Douglas A., Al–Massadi, Omar, Varela, Luis, Gándara, Marina, López–Soriano, Francisco–Javier, Gallego, Rosalía, Seoane, Luisa M., Argiles, Josep M., López, Miguel, Davis, Roger J., Sabio, Guadalupe, Rohner–Jeanrenaud, Françoise, Rahmouni, Kamal, Dieguez, Carlos, and Nogueiras, Ruben

Published
2013
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25. Effects of Cigarette Smoke on Adipose and Skeletal Muscle Tissue:: In Vivo and In Vitro Studies

Author

Afd Pharmacology, Pharmacology, Wang, Lei, van Iersel, Lieke E J, Pelgrim, Charlotte E, Lu, Jingyi, van Ark, Ingrid, Leusink-Muis, Thea, Gosker, Harry R, Langen, Ramon C J, Schols, Annemie M W J, Argilés, Josep M, van Helvoort, Ardy, Kraneveld, Aletta D, Garssen, Johan, Henricks, Paul A J, Folkerts, Gert, Braber, Saskia, Afd Pharmacology, Pharmacology, Wang, Lei, van Iersel, Lieke E J, Pelgrim, Charlotte E, Lu, Jingyi, van Ark, Ingrid, Leusink-Muis, Thea, Gosker, Harry R, Langen, Ramon C J, Schols, Annemie M W J, Argilés, Josep M, van Helvoort, Ardy, Kraneveld, Aletta D, Garssen, Johan, Henricks, Paul A J, Folkerts, Gert, and Braber, Saskia

Published
2022

26. Cancer Cachexia

Author

Argilés, Josep M., López-Soriano, Francisco J., Busquets, Sílvia, and Lang, Florian, editor

Published
2009
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37. Nutritional Recommendations for the Management of Sarcopenia

Author

Morley, John E., Argiles, Josep M., Evans, William J., Bhasin, Shalender, Cella, David, Deutz, Nicolaas E.P., Doehner, Wolfram, Fearon, Ken C.H., Ferrucci, Luigi, Hellerstein, Marc K., Kalantar-Zadeh, Kamyar, Lochs, Herbert, MacDonald, Neil, Mulligan, Kathleen, Muscaritoli, Maurizio, Ponikowski, Piotr, Posthauer, Mary Ellen, Fanelli, Filippo Rossi, Schambelan, Morrie, Schols, Annemie M.W.J., Schuster, Michael W., and Anker, Stefan D.

Published
2010
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50. A differential pattern of gene expression in skeletal muscle of tumor-bearing rats reveals dysregulation of excitation–contraction coupling together with additional muscle alterations

Author

Fontes-Oliveira, Cibely Cristine, Busquets, Sílvia, Fuster, Gemma, Ametller, Elisabet, Figueras, Maite, Olivan, Mireia, Toledo, Míriam, López-Soriano, Francisco J., Qu, Xiaoyan, Demuth, Jeffrey, Stevens, Paula, Varbanov, Alex, Wang, Feng, Isfort, Robert J., and Argilés, Josep M.

Published
2014
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