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1. Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE)

Author

Carbonell, Cristina, Marcos, Miguel, Guillén-del-Castillo, Alfredo, Rubio-Rivas, Manuel, Argibay, Ana, Marín-Ballvé, Adela, Rodríguez-Pintó, Ignasi, Baldà-Masmiquel, Maria, Callejas-Moraga, Eduardo, Colunga, Dolores, Sáez-Comet, Luis, González-Echávarri, Cristina, Ortego-Centeno, Norberto, Marí-Alfonso, Begoña, Vargas-Hitos, José-Antonio, Todolí-Parra, José-Antonio, Trapiella, Luis, Herranz-Marín, María-Teresa, Freire, Mayka, Castro-Salomó, Antoni, Perales-Fraile, Isabel, Madroñero-Vuelta, Ana-Belén, Sánchez-García, María-Esther, Ruiz-Muñoz, Manuel, González-García, Andrés, Sánchez-Redondo, Jorge, de-la-Red-Bellvis, Gloria, Fernández-Luque, Alejandra, Muela-Molinero, Alberto, Lledó, Gema-María, Tolosa-Vilella, Carles, Fonollosa-Pla, Vicent, Chamorro, Antonio-Javier, and Simeón-Aznar, Carmen-Pilar

Published
2022
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2. Impact of interstitial lung disease on the survival of systemic sclerosis with pulmonary arterial hypertension

Author

Guillén-Del-Castillo, Alfredo, Meseguer, Manuel López, Fonollosa-Pla, Vicent, Giménez, Berta Sáez, Colunga-Argüelles, Dolores, Revilla-López, Eva, Rubio-Rivas, Manuel, Ropero, Maria Jose Cristo, Argibay, Ana, Barberá, Joan Albert, Salas, Xavier Pla, Meñaca, Amaya Martínez, Vuelta, Ana Belén Madroñero, Padrón, Antonio Lara, Comet, Luis Sáez, Morera, Juan Antonio Domingo, González-Echávarri, Cristina, Mombiela, Teresa, Ortego-Centeno, Norberto, González, Manuela Marín, Tolosa-Vilella, Carles, Blanco, Isabel, Subías, Pilar Escribano, and Simeón-Aznar, Carmen Pilar

Published
2022
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3. Author Correction: Impact of interstitial lung disease on the survival of systemic sclerosis with pulmonary arterial hypertension

Author

Guillén-Del-Castillo, Alfredo, Meseguer, Manuel López, Fonollosa-Pla, Vicent, Giménez, Berta Sáez, Colunga-Argüelles, Dolores, Revilla-López, Eva, Rubio-Rivas, Manuel, Ropero, Maria Jose Cristo, Argibay, Ana, Barberá, Joan Albert, Salas, Xavier Pla, Meñaca, Amaya Martínez, Vuelta, Ana Belén Madroñero, Padrón, Antonio Lara, Comet, Luis Sáez, Morera, Juan Antonio Domingo, González-Echávarri, Cristina, Mombiela, Teresa, Ortego-Centeno, Norberto, González, Manuela Marín, Tolosa-Vilella, Carles, Blanco, Isabel, Subías, Pilar Escribano, and Simeón-Aznar, Carmen Pilar

Published
2022
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6. Exposure to different occupational chemicals and clinical phenotype of a cohort of patients with systemic sclerosis

Author

Freire, Mayka, Sopeña, Bernardo, González-Quintela, Arturo, del Castillo, Alfredo Guillén, Moraga, Eduardo Callejas, Lledó-Ibañez, Gema M., Rubio-Rivas, Manuel, Trapiella, Luis, Argibay, Ana, Tolosa, Carles, Alfonso, Begoña Marí, Vargas-Hitos, Jose Antonio, Salas, Xavier Pla, González-Echávarri, Cristina, Chamorro, Antonio-J, Fraile, Isabel Perales, García, Andrés González, de la Red Bellvis, Gloria, Bello, David Bernal, Salomó, Antoni Castro, Jiménez Pérez de Heredia, Iratxe, Marín-Ballve, Adela, Rodríguez-Pintó, Ignasi, Saez-Comet, Luis, Ortego-Centeno, Norberto, Todolí-Parra, José Antonio, Fonollosa Pla, Vicent, and Simeón-Aznar, Carmen Pilar

Published
2024
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7. Left ventricular diastolic dysfunction in systemic sclerosis: Clinical, immunological and survival differences in the Spanish RESCLE registry

Author

González García, Andrés, primary, Fabregate, Martin, additional, Manzano, Luis, additional, Guillén del Castillo, Alfredo, additional, Rubio Rivas, Manuel, additional, Argibay, Ana, additional, Marín Ballvé, Adela, additional, Rodríguez Pintó, Ignasi, additional, Pla Salas, Xavier, additional, Marí-Alfonso, Begoña, additional, Callejas Moraga, Eduardo, additional, Colunga Argüelles, Dolores, additional, Sáez Comet, Luis, additional, González-Echávarri, Cristina, additional, Ortego-Centeno, Norberto, additional, Vargas Hitos, José Antonio, additional, Todolí Parra, José Antonio, additional, Trapiella Martínez, Luis, additional, Herranz Marín, María Teresa, additional, Freire, Mayka, additional, Chamorro, Antonio-J, additional, Perales Fraile, Isabel, additional, Madroñero Vuelta, Ana Belén, additional, Sánchez Trigo, Sabela, additional, Tolosa Vilella, Carles, additional, Fonollosa Pla, Vicent, additional, and Simeón Aznar, Carmen Pilar, additional

Published
2022
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8. Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE)

Author

Universidad de Sevilla. Departamento de Medicina, Carbonell, Cristina, Marcos, Miguel, Guillén del Castillo, Alfredo, Rubio-Rivas, Manuel, Argibay, Ana, Marín Ballve, Adela, Sánchez García, Esther, Simeón Aznar, Carmen Pilar, Universidad de Sevilla. Departamento de Medicina, Carbonell, Cristina, Marcos, Miguel, Guillén del Castillo, Alfredo, Rubio-Rivas, Manuel, Argibay, Ana, Marín Ballve, Adela, Sánchez García, Esther, and Simeón Aznar, Carmen Pilar

Abstract

Aim: Patients with systemic sclerosis (SSc) are at increased risk of cancer, a growing cause of non–SSc-related death among these patients. We analyzed the increased cancer risk among Spanish patients with SSc using standardized incidence ratios (SIRs) and identified independent cancer risk factors in this population. Material and methods: Spanish Scleroderma Registry data were analyzed to determine the demographic charac teristics of patients with SSc, and logistic regression was used to identify cancer risk factors. SIRs with 95% confidence intervals (CIs) relative to the general Spanish population were calculated. Results: Of 1930 patients with SSc, 206 had cancer, most commonly breast, lung, hematological, and colorectal cancers. Patients with SSc had increased risks of overall cancer (SIR 1.48, 95% CI 1.36–1.60; P < 0.001), and of lung (SIR 2.22, 95% CI 1.77–2.73; P < 0.001), breast (SIR 1.31, 95% CI 1.10–1.54; P = 0.003), and hemato logical (SIR 2.03, 95% CI 1.52–2.62; P < 0.001) cancers. Cancer was associated with older age at SSc onset (odds ratio [OR] 1.22, 95% CI 1.01–1.03; P < 0.001), the presence of primary biliary cholangitis (OR 2.35, 95% CI 1.18–4.68; P = 0.015) and forced vital capacity <70% (OR 1.8, 95% CI 1.24–2.70; P = 0.002). The presence of anticentromere antibodies lowered the risk of cancer (OR 0.66, 95% CI 0.45–0.97; P = 0.036). Conclusions: Spanish patients with SSc had an increased cancer risk compared with the general population. Some characteristics, including specific autoantibodies, may be related to this increased risk.

Published
2022

9. Impact of interstitial lung disease on the survival of systemic sclerosis with pulmonary arterial hypertension

Author

Guillén-del Castillo, Alfredo, López-Meseguer, Manuel, Fonollosa-Pla, Vicent, Sáez, Berta, Colunga-Argüelles, Dolores, Revilla-López, Eva, Rubio-Rivas, Manuel, Cristo Ropero, María José, Argibay, Ana, Barberà, Joan Albert, Pla-Salas, Xavier, Martínez-Meñaca, Amaya, Madroñero-Vuelta, Ana Belén, Lara Padrón, Antonio, Sáez-Comet, Luis, Domingo Morera, Juan Antonio, González-Echávarri, Cristina, Mombiela, Teresa, Ortego-Centeno, Norberto, Marín González, Manuela, Tolosa-Vilella, Carles, Blanco, Isabel, Escribano-Subias, Pilar, Simeón-Aznar, Carmen Pilar, RESCLE Consortium, REHAP Consortium, Guillén-del Castillo, Alfredo, López-Meseguer, Manuel, Fonollosa-Pla, Vicent, Sáez, Berta, Colunga-Argüelles, Dolores, Revilla-López, Eva, Rubio-Rivas, Manuel, Cristo Ropero, María José, Argibay, Ana, Barberà, Joan Albert, Pla-Salas, Xavier, Martínez-Meñaca, Amaya, Madroñero-Vuelta, Ana Belén, Lara Padrón, Antonio, Sáez-Comet, Luis, Domingo Morera, Juan Antonio, González-Echávarri, Cristina, Mombiela, Teresa, Ortego-Centeno, Norberto, Marín González, Manuela, Tolosa-Vilella, Carles, Blanco, Isabel, Escribano-Subias, Pilar, Simeón-Aznar, Carmen Pilar, RESCLE Consortium, and REHAP Consortium

Abstract

To assess severity markers and outcomes of patients with systemic sclerosis (SSc) with or without pulmonary arterial hypertension (PAH-SSc/non-PAH-SSc), and the impact of interstitial lung disease (ILD) on PAH-SSc. Non-PAH-SSc patients from the Spanish SSc registry and PAH-SSc patients from the Spanish PAH registry were included. A total of 364 PAH-SSc and 1589 non-PAH-SSc patients were included. PAH-SSc patients had worse NYHA-functional class (NYHA-FC), worse forced vital capacity (FVC) (81.2 ± 20.6% vs 93.6 ± 20.6%, P < 0.001), worse tricuspid annular plane systolic excursion (TAPSE) (17.4 ± 5.2 mm vs 19.9 ± 6.7 mm, P < 0.001), higher incidence of pericardial effusion (30% vs 5.2%, P < 0.001) and similar prevalence of ILD (41.8% vs. 44.9%). In individuals with PAH-SSc, ILD was associated with worse hemodynamics and pulmonary function tests (PFT). Up-front combination therapy was used in 59.8% and 61.7% of patients with and without ILD, respectively. Five-year transplant-free survival rate was 41.1% in PAH-SSc patients and 93.9% in non-PAH-SSc patients (P < 0.001). Global survival of PAH-SSc patients was not affected by ILD regardless its severity. The multivariate survival analysis in PAH-SSc patients confirmed age at diagnosis, worse NYHA-FC, increased PVR, reduced DLCO, and lower management with up-front combination therapy as major risk factors. In conclusion, in PAH-SSc cohort risk of death was greatly increased by clinical, PFT, and hemodynamic factors, whereas it was decreased by up-front combination therapy. Concomitant ILD worsened hemodynamics and PFT in PAH-SSc but not survival regardless of FVC impairment.

Published
2022

11. Corrigendum to ‘Spanish scleroderma risk score (RESCLESCORE) to predict 15-year all-cause mortality in scleroderma patients at the time of diagnosis based on the RESCLE cohort: Derivation and internal validation’ [AUTREV 19-5 (2020) 102507]

Author

Rubio-Rivas, Manuel, primary, Corbella, Xavier, additional, Guillén-del-Castillo, Alfredo, additional, Tolosa Vilella, Carles, additional, Colunga Argüelles, Dolores, additional, Argibay, Ana, additional, Vargas Hitos, José Antonio, additional, Todolí Parra, José Antonio, additional, González-Echávarri, Cristina, additional, Ortego-Centeno, Norberto, additional, Trapiella Martínez, Luis, additional, Rodríguez Carballeira, Mónica, additional, Marín Ballvé, Adela, additional, Pla Salas, Xavier, additional, Perales Fraile, Isabel, additional, Chamorro, Antonio-J, additional, Madroñero Vuelta, Ana Belén, additional, Freire, Mayka, additional, Ruiz Muñoz, Manuel, additional, González García, Andrés, additional, Pons Martín del Campo, Isaac, additional, Sánchez García, María Esther, additional, Bernal Bello, David, additional, Espinosa, Gerard, additional, García Hernández, Francisco José, additional, Sáez Comet, Luis, additional, Ríos Blanco, Juan José, additional, Fernández de la Puebla Giménez, Rafael Ángel, additional, Sánchez Trigo, Sabela, additional, Fonollosa Pla, Vicent, additional, and Simeón Aznar, Carmen Pilar, additional

Published
2021
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12. Spanish scleroderma risk score (RESCLESCORE) to predict 15-year all-cause mortality in scleroderma patients at the time of diagnosis based on the RESCLE cohort: Derivation and internal validation

Author

Rubio-Rivas, Manuel, primary, Corbella, Xavier, additional, Guillén-del-Castillo, Alfredo, additional, Tolosa Vilella, Carles, additional, Colunga Argüelles, Dolores, additional, Argibay, Ana, additional, Vargas Hitos, José Antonio, additional, Todolí Parra, José Antonio, additional, González-Echávarri, Cristina, additional, Ortego-Centeno, Norberto, additional, Trapiella Martínez, Luis, additional, Rodríguez Carballeira, Mónica, additional, Marín Ballvé, Adela, additional, Pla Salas, Xavier, additional, Perales Fraile, Isabel, additional, Chamorro, Antonio-J, additional, Madroñero Vuelta, Ana Belén, additional, Freire, Mayka, additional, Ruiz Muñoz, Manuel, additional, González García, Andrés, additional, Pons Martín del Campo, Isaac, additional, Sánchez García, María Esther, additional, Bernal Bello, David, additional, Espinosa, Gerard, additional, García Hernández, Francisco José, additional, Sáez Comet, Luis, additional, Ríos Blanco, Juan José, additional, Fernández de la Puebla Giménez, Rafael Ángel, additional, Sánchez Trigo, Sabela, additional, Fonollosa Pla, Vicent, additional, and Simeón Aznar, Carmen Pilar, additional

Published
2020
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13. AB1154 CLINICAL SIGNIFICANCE OF MONOSPECIFIC ANTI-DFS70 IN ANTINUCLEOLAR ANTIBODY (ANA)-POSITIVE PATIENTS

Author

Lima, Olalla, primary, Argibay, Ana, additional, Estevez, Melania, additional, Maure, Brenda, additional, Suárez, Milagros, additional, Rodríguez Ferreira, Lorena María, additional, Triñanes, Caritina Vázquez, additional, Gimena, Beatriz, additional, Castro, Rut Lorenzo, additional, Alvarez, Iria Villaverde, additional, and Rivera, Alberto, additional

Published
2019
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14. The incidence rate of pulmonary arterial hypertension and scleroderma renal crisis in systemic sclerosis patients with digital ulcers on endothelin antagonist receptors (ERAs) and phosphodiesterase-5 inhibitors (PDE5i).

Author

Pestaña-Fernández, Melani, Rubio-Rivas, Manuel, Tolosa-Vilella, Carles, Guillén-Del-Castillo, Alfredo, Colunga-Argüelles, Dolores, Argibay, Ana, Marí-Alfonso, Begoña, Marín-Ballvé, Adela, Pla-Salas, Xavier, Chamorro, Antonio-J, Castro-Salomó, Antoni, Madroñero-Vuelta, Ana Belén, Sánchez-García, María Esther, Sáez-Comet, Luis, González-Echávarri, Cristina, Ortego-Centeno, Norberto, Vargas-Hitos, José Antonio, Todolí-Parra, José Antonio, Trapiella-Martínez, Luis, and Lledó, Gema María

Subjects
KIDNEY disease diagnosis, CELL receptors, CONFIDENCE intervals, REPORTING of diseases, ENDOTHELINS, FINGERS, KIDNEY diseases, LONGITUDINAL method, MEDICAL records, PULMONARY hypertension, SYSTEMIC scleroderma, TIME, DISEASE incidence, DISEASE prevalence, RETROSPECTIVE studies, PHOSPHODIESTERASE inhibitors, DESCRIPTIVE statistics, ACQUISITION of data methodology, SKIN ulcers, CHEMICAL inhibitors, DISEASE complications
Abstract

Introduction Endothelin antagonist receptors (ERAs) and phosphodiesterase-5 inhibitors (PDE5i) are beneficial in pulmonary arterial hypertension (PAH) and digital ulcers (DU) and prevent from DU recurrences. Our study aimed to determine the difference in the incidence rate of PAH and scleroderma renal crisis (SRC) in patients with SSc and DU (SSc-DU) under ERAs/PDE5i or without treatment. Methods We conducted a retrospective cohort study including SSc-DU patients from the Spanish Scleroderma Registry (RESCLE). The primary outcome was the incidence rate of PAH and SRC in patients under ERAs/PDE5i or not. Results Some 544 patients out of 1817 (29.9%) in the RESCLE database had DU, 221 (40.6%) under ERAs/PDE5i and 323 (59.4%) not. The incidence rate (95% CI) difference between patients under treatment or not under did not reach statistical significance in PAH [−0.1 (−4.8, 4.69), P  = 0.988] or in SRC [0.7 (−2.2, 3.7), P  = 0.620]. However, the time from the first DU to the diagnosis of SRC was delayed in treated patients [mean (s. d.) 7.6 (5.8) years vs 2.9  (5.3); P  = 0.021]. The dcSSc subset was more prevalent in the treatment group (36 vs 26%; P  = 0.018), along with anti-topoisomerase I antibodies (34 vs 18%; P  < 0.001) and tendon friction rubs (12 vs 6%; P  = 0.038), whereas the lcSSc subset was more prevalent in the no-treatment group (57 vs 66%; P  = 0.031) along with ACA (37 vs 46%; P  = 0.031). Conclusion There was no difference in the incidence rate of PAH and SRC between groups. However, treatment with ERAs and/or PDE5i appeared to delay the occurrence of SRC. [ABSTRACT FROM AUTHOR]

Published
2021
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15. Las revistas femeninas del siglo XX

Author

Boville Blanco-Argibay, Ana and Ramos Domingo, José

Subjects
Comunicación, Tesis y disertaciones académicas
Abstract

Se realiza un recorrido por la historia de las revistas femeninas para mostrar cómo era el contenido, el público al que se dirigían y la estética de las mismas. Se hace hincapié en los felices años veinte, los depresivos años treinta, la post-guerra de los cuarenta y los años cincuenta, viendo la luz y la modernidad a lo lejos, en la primera mitad de siglo

Published
2014

17. Influencia de la edad en la enfermedad neumocócica invasiva y en la resistencia a antimicrobianos

Author

Pérez-Rodríguez, Maria Teresa, primary, Sopeña, Bernardo, additional, Méndez-Lage, Susana, additional, Casares, M. de los Angeles, additional, Constenla, Lucía, additional, Argibay, Ana, additional, Nodar, Andrés, additional, Villaverde, Iria, additional, Martínez-Vázquez, César, additional, and Álvarez-Fernández, Maximiliano, additional

Published
2014
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19. [Influence of age on the clinical manifestations of invasive pneumococcal disease and antibiotic resistance rates].

Author

Pérez-Rodríguez MT, Sopeña B, Méndez-Lage S, Casares Mde L, Constenla L, Argibay A, Nodar A, Villaverde I, Martínez-Vázquez C, and Álvarez-fernández M

Subjects
Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Prognosis, Retrospective Studies, Serotyping, Streptococcus pneumoniae classification, Streptococcus pneumoniae isolation & purification, Young Adult, Bacteremia diagnosis, Bacteremia microbiology, Bacteremia mortality, Drug Resistance, Bacterial, Pneumococcal Infections diagnosis, Pneumococcal Infections microbiology, Pneumococcal Infections mortality
Abstract

Background and Objective: Invasive pneumococcal disease (IPD) shows different epidemiological characteristics depending on age and pneumococcus serotype. The aims of the work were to analyze the clinical manifestations and mortality associated with IPD, the serotype isolated and the antibiotic resistance rates in different age groups., Patients and Method: Retrospectively, 141 patients with IPD diagnosed between 2002 and 2008 were studied. Patients were classified in 4 age groups: ≤ 2 year-old, 3-14 year-old, 15-64 year-old and ≥ 65 year-old., Results: Pneumonia was the most common manifestation in all age groups (71%). Pneumococcal meningitis was more prevalent in patients ≤ 2 year-old (28 vs. 9%, P=.054) and empyema was more frequent in those between 3-14 year-old (31 vs. 5%, P<.001). Mortality was associated with age ≥ 65 year-old (odds ratio [OR] 7, 95% confidence interval [95% CI] 1.9-28.9), primary bacteremia (OR 7, 95% CI 1.9-28.9) and orotracheal intubation (OR 9, 95% CI 1.9-41.1). The more prevalent serotypes among patients ≤ 2 year-old were 14, 19A and 19F. The serotype 1 was most common in patients between 3-14 year-old and serotype 3 in those ≥ 65 year-old. A higher rate of non-susceptible penicillin strains was observed in pediatric population (42 vs. 19%, P=.007)., Conclusions: Age was related to the clinical manifestations, mortality and antibiotic resistance rates. Primary bacteremia was one of the risk factors of mortality., (Copyright © 2013 Elsevier España, S.L.U. All rights reserved.)

Published
2014
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