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The mechanical properties of sclera play an important role in ocular functions, protection, and disease. Modulating the sclera's properties by exogenous crosslinking offers a way to expand the tissue's range of properties for study of the possible influences on the eye's behavior and diseases such as glaucoma and myopia. The focus of this work was to evaluate the effects of genipin crosslinking targeting the porcine perilimbal sclera (PLS) since the stiffness of this tissue was previously found in a number of studies to influence the eye's intraocular pressure (IOP). The work includes experiments on tensile test specimens and whole globes. The specimen tests showed decreased strain-rate dependence and increased relaxation stress due to the cross-linker. Whole globe perfusion experiments demonstrated that eyes treated with genipin in the perilimbal region had increased IOPs compared to the control globes. Migration of the cross-linker from the target tissue to other tissues is a confounding factor in whole globe, biomechanical measurements, with crosslinking. A novel quantitative genipin assay of the trabecular meshwork (TM) was developed to exclude globes where the TM was inadvertently crosslinked. The perfusion study, therefore, suggests that elevated stiffness of the PLS can significantly increase IOP apart from effects of the TM in the porcine eye. These results demonstrate the importance of PLS biomechanics in aqueous outflow regulation and support additional investigations into the distal outflow pathways as a key source of outflow resistance. [ABSTRACT FROM AUTHOR]

The constitutive behavior of bovine scleral and corneal tissues is measured in tension and compression, at quasi-static and moderate strain rates. Experiments are conducted at strain rates up to about 50 strain per second by a pneumatic testing system developed to overcome noise and measurement difficulties associated with the time dependent test of low impedance materials. Results for the tissues at room and the natural bovine body temperatures are similar and indicate that ocular tissue exhibits nonlinear stiffening for increasing strain rates, a phenomena termed rate hardening. For example, at a tensile strain rate of 29/s, corneal tissue is found to develop 10 times the stress that it does quasi-statically at the same strain. Thus, conventional constitutive models will grossly underpredict stresses occurring in the corneo-scleral shell due to moderate dynamic events. This has implication to the accuracy of ocular injury models, the study of the stress field in the corneo-scleral shell for glaucoma research and tonometry measurements. The measured data at various strain rates is represented using the general framework of a constitutive model that has been used to represent biological tissue mechanical data. Here it is extended to represent the measured data of the ocular tissues over the range of tested strain rates. Its form allows for straightforward incorporation in various numerical codes. The experimental and analytical methods developed here are felt to be applicable to the test of human ocular tissue. [ABSTRACT FROM AUTHOR]

The high strain-rate constitutive behavior of polymer composites with various natural fibers is studied. Hemp, hemp/glass hybrid, cellulose, and wheat straw-reinforced polymeric composites have been manufactured, and a split-Hopkinson pressure bar apparatus has been designed to measure the dynamic stress–strain response of the materials. Using the apparatus, compressive stress–strain curves have been obtained that reveal the materials’ constitutive characteristics at strain rates between 600 and 2400 strain/s. Primary findings indicate that natural fibers in thermoset composites dissipate energy at lower levels of stress and higher strain than glass-reinforced composites. In the case of thermoplastic matrices, the effect on energy dissipation of natural fibers vs. conventional talc reinforcements is highly dependent on resin properties. Natural fibers in polypropylene homopolymer show improved reinforcement but have degraded energy dissipation compared to talc. Whereas in polypropylene copolymer, natural fibers result in improved energy dissipation compared to talc. These data are useful for proper design, analysis, and simulation of lightweight biocomposites. [ABSTRACT FROM AUTHOR]

It was theoretically shown by the authors in a previous article that by adding a layer of metal on the outside of a carbon fiber-reinforced composite shaft, the bending natural frequencies of the shaft could be increased in some cases due to reduction of the effects of shear deformation by the metal layer. In the present study, composite shafts having a metal casing have been manufactured by spray deposition process over filament wound, fiber reinforced polymeric shafts. The natural frequencies of the spray deposited composite shafts have been measured and found to compare well to theoretically calculated values. The experiments also confirm the shear deformation effect described above. Some manufacturing issues on the spray deposition of metals over carbon fiber-reinforced plastics are addressed. [ABSTRACT FROM AUTHOR]