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8 results on '"Argentinean plants"'

1. Antioxidant, Gastroprotective, Cytotoxic Activities and UHPLC PDA-Q Orbitrap Mass Spectrometry Identification of Metabolites in Baccharis grisebachii Decoction

Author

Jessica Gómez, Mario J. Simirgiotis, Beatriz Lima, Jésica D. Paredes, Carlos M. Villegas Gabutti, Carlos Gamarra-Luques, Jorge Bórquez, Lorena Luna, Graciela H. Wendel, Alejandra O. Maria, Gabriela E. Feresin, and Alejandro Tapia

Subjects
Argentinean plants, UHPLC Orbitrap (Q-OT), flavonoids, cinnamic acids derivatives, Organic chemistry, QD241-441
Abstract

The decoction of the local plant Baccharis grisebachii is used as a digestive, gastroprotective, external cicatrizing agent and antiseptic in Argentine. A lyophilized decoction (BLD) from the aerial parts of this plant was evaluated regarding its anti-ulcer, antioxidant and cytotoxic activities and the bioactivities were supported by UHPLC-MS metabolome fingerprinting which revealed the presence of several small bioactive compounds. The antioxidant properties were evaluated by DPPH, TEAC, FRAP and lipoperoxidation inhibition in erythrocytes methods, and the antibacterial activity was evaluated according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. The BLD showed a moderate free radical scavenging activity in the DPPH (EC50 = 106 µg/mL) and lipid peroxidation in erythrocytes assays (67%, at 250 µg/mL). However, the BLD had the highest gastroprotective effect at a dose of 750 mg/kg with a ninety-three percent inhibition of damage through a mechanism that involve NO and prostaglandins using the ethanol-induced gastric damage in a standard rat model. On the other hand, BLD does not induce cytotoxic changes on human tumor and no-tumor cell lines at the concentrations assayed. Regarding the metabolomic analysis, thirty-one compounds were detected and 30 identified based on UHPLC-OT-MS including twelve flavonoids, eleven cinnamic acid derivatives, one coumarin, one stilbene and two other different phenolic compounds. The results support that the medicinal decoction of Baccharis grisebachii is a valuable natural product with gastroprotective effects and with potential to improve human health that opens a pathway for the development of important phytomedicine products.

Published
2019
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2. Antifungal Activity of Traditional Medicinal Plants from Argentina: Effect of their Combination with Antifungal Drugs

Author

Estefanía Cordisco, Maximiliano Sortino, and Laura Svetaz

Subjects
0301 basic medicine, Antifungal, medicine.drug_class, Antifungal drugs, Biology, 01 natural sciences, 03 medical and health sciences, ANTIFUNGAL, Drug Discovery, ARGENTINEAN PLANTS, medicine, ETHNOPHARMACOLOGY, COMBINATION, Candida albicans, Medicinal plants, Traditional medicine, Ciencias Químicas, biology.organism_classification, 0104 chemical sciences, ENHANCERS, 010404 medicinal & biomolecular chemistry, Química Orgánica, 030104 developmental biology, CANDIDA ALBICANS, Complementary and alternative medicine, CIENCIAS NATURALES Y EXACTAS
Abstract

The incidence of fungal infections has experienced a marked increase in the last two decades being limited to a few drugs with serious drawbacks. Combination therapy has emerged as an approach to improve the efficacy of currently used antifungal therapy that also may delay the evolution of resistance. The objectives of this work are to present a bibliographic search on the plants used in traditional medicine in Argentina for ailments related to fungal infections and to investigate the antifungal activity of currently used antifungal drugs in combination with natural extracts. Results of the bibliographic investigation showed that 153 species belonging to 56 families and 120 genera from Argentina are applied to treat signs and symptoms considered to maintain ethnopharmacological uses related to fungal infections, mainly for skin and mucosal conditions. Regarding the evaluation of the antifungal activity of combinations between extracts and antifungal drugs, we observed that extracts from plants species belonging to a genera traditionally used for ailments related to fungal infections have more chances of enhancing the activity of amphotericin B, fluconazole and itraconazole. In addition, we observed that there is a greater chance of finding an enhancement in the activity of the commercial antifungals when the combination is performed with extracts that have shown activity in solitary. Nevertheless, inactive extracts that would have been discarded according to the classic strategy displayed activity in combination and they continue being potential candidates in the search for new antifungals. Fil: Cordisco, Estefanía. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina Fil: Sortino, Maximiliano Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina Fil: Svetaz, Laura Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Química Orgánica. Área Farmacognosia; Argentina

Published
2019

3. Bioactivity of Argentinean essential oils against permethrinresistant head lice, Pediculus humanus capitis.

Author

Toloza, Ariel C., Zygadlo, Julio, Biurrun, Fernando, Rotman, Alicia, and Picollo, María I.

Subjects
*INSECTS, *INSECTICIDE resistance, *PEDICULOSIS, *BOTANICAL insecticides, *FUMIGANTS, *PREVENTION
Abstract

The article discusses a study on several plant derived insecticides against head louse, Pediculus humanus capitis. It is stated that due to the significant differences in the fumigant activity of plant derived oils against head lice, the need of these insecticides have been increased. It further name the most effective plant derived oils or insecticides including Cinnamomum porphyrium, Aloysia citriodora and Myrcianthes pseudomato.

Published
2010
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4. Photoprotective Effect of the PlantCollaea argentinaagainst Adverse Effects Induced by Photodynamic Therapy

Author

Daniel A. Sáenz, Alcira Batlle, Gabriela Di Venosa, Adriana Casas, Pablo Vallecorsa, and Leandro Mamone

Subjects
CIENCIAS MÉDICAS Y DE LA SALUD, Article Subject, Stereochemistry, medicine.medical_treatment, lcsh:TJ807-830, lcsh:Renewable energy sources, Photodynamic therapy, Tumor cells, Medicina Clínica, Pharmacology, Oncología, PHOTODYNAMIC THERAPY, chemistry.chemical_compound, purl.org/becyt/ford/3.2 [https], polycyclic compounds, ARGENTINEAN PLANTS, medicine, General Materials Science, Photosensitizer, Adverse effect, Renewable Energy, Sustainability and the Environment, Collaea argentina, Chemistry, Singlet oxygen, PHOTOPROTECTION, General Chemistry, eye diseases, Atomic and Molecular Physics, and Optics, Treatment modality, Photoprotection, purl.org/becyt/ford/3 [https], COLLAEA ARGENTINA
Abstract

Photodynamic therapy (PDT) is a treatment modality for tumours and other accessible lesions based on the combination of light and a photosensitizer (PS) accumulated in the target tissue. The main disadvantage of PDT is PS retention after treatment during long time periods that conduces to cutaneous damage. It is believed that singlet oxygen is responsible for that skin photosensitization. The aim of this work was to evaluate the photoprotective activity of the methanolic extract of the Argentinian plant Collaea argentina against PDT under several treatments and employing different PSs. C. argentina exhibited photoprotective activity against aminolevulinic acid- (ALA-) PDT in the LM2 murine adenocarcinoma cell line. The photoprotection was dependant on the extract concentration and the incubation time, being detectable from 40 μg/mL onwards and at least after 3 h exposure of the cells. C. argentina extract protects these mammalian tumor cells against PDT effects, and it interferes with the oxygen singlet production from PSs during PDT treatment. We propose that it will be a promising agent to protect cells against PDT-induced skin sensitivity. Fil: Mamone, Leandro Ariel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina Fil: Saenz, Daniel Alberto. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina Fil: Vallecorsa, Pablo Daniel. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina Fil: Batlle, Alcira Maria del C.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina Fil: Di Venosa, Gabriela Mariana. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina Fil: Casas, Adriana Gabriela. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Centro de Invest. Sobre Porfirinas y Porfirias; Argentina

Published
2014

5. Antioxidant, Gastroprotective, Cytotoxic Activities and UHPLC PDA-Q Orbitrap Mass Spectrometry Identification of Metabolites in Baccharis grisebachii Decoction

Author

Gabriela Egly Feresin, Carlos M Villegas Gabutti, Mario J. Simirgiotis, Beatriz Lima, Jésica Daniela Paredes, Alejandro Tapia, Graciela Haydée Wendel, Jorge Bórquez, Carlos Gamarra-Luques, Lorena Luna, Jessica Gómez, and A. O. M. María

Subjects
Antioxidant, DPPH, medicine.medical_treatment, Pharmaceutical Science, Decoction, CINNAMIC ACIDS DERIVATIVES, 01 natural sciences, Antioxidants, Mass Spectrometry, Analytical Chemistry, Lipid peroxidation, chemistry.chemical_compound, Phytomedicine, Drug Discovery, Chromatography, High Pressure Liquid, 0303 health sciences, biology, Traditional medicine, Baccharis, cinnamic acids derivatives, Chemistry (miscellaneous), Molecular Medicine, purl.org/becyt/ford/3 [https], Antibacterial activity, Argentinean plants, purl.org/becyt/ford/3.5 [https], Article, Cinnamic acid, lcsh:QD241-441, 03 medical and health sciences, lcsh:Organic chemistry, Picrates, ARGENTINEAN PLANTS, medicine, Humans, UHPLC Orbitrap (Q-OT), Physical and Theoretical Chemistry, 030304 developmental biology, 010405 organic chemistry, Biphenyl Compounds, Organic Chemistry, FLAVONOIDS, HCT116 Cells, biology.organism_classification, 0104 chemical sciences, UHPLC ORBITRAP (Q-OT), chemistry, Cinnamates, flavonoids, Lipid Peroxidation
Abstract

The decoction of the local plant Baccharis grisebachii is used as a digestive, gastroprotective, external cicatrizing agent and antiseptic in Argentine. A lyophilized decoction (BLD) from the aerial parts of this plant was evaluated regarding its anti-ulcer, antioxidant and cytotoxic activities and the bioactivities were supported by UHPLC-MS metabolome fingerprinting which revealed the presence of several small bioactive compounds. The antioxidant properties were evaluated by DPPH, TEAC, FRAP and lipoperoxidation inhibition in erythrocytes methods, and the antibacterial activity was evaluated according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. The BLD showed a moderate free radical scavenging activity in the DPPH (EC50 = 106 &micro, g/mL) and lipid peroxidation in erythrocytes assays (67%, at 250 &micro, g/mL). However, the BLD had the highest gastroprotective effect at a dose of 750 mg/kg with a ninety-three percent inhibition of damage through a mechanism that involve NO and prostaglandins using the ethanol-induced gastric damage in a standard rat model. On the other hand, BLD does not induce cytotoxic changes on human tumor and no-tumor cell lines at the concentrations assayed. Regarding the metabolomic analysis, thirty-one compounds were detected and 30 identified based on UHPLC-OT-MS including twelve flavonoids, eleven cinnamic acid derivatives, one coumarin, one stilbene and two other different phenolic compounds. The results support that the medicinal decoction of Baccharis grisebachii is a valuable natural product with gastroprotective effects and with potential to improve human health that opens a pathway for the development of important phytomedicine products.

Published
2019

6. Antioxidant, Gastroprotective, Cytotoxic Activities and UHPLC PDA-Q Orbitrap Mass Spectrometry Identification of Metabolites in Baccharis grisebachii Decoction.

Author

Gómez, Jessica, Simirgiotis, Mario J., Lima, Beatriz, Paredes, Jésica D., Villegas Gabutti, Carlos M., Gamarra-Luques, Carlos, Bórquez, Jorge, Luna, Lorena, Wendel, Graciela H., Maria, Alejandra O., Feresin, Gabriela E., Tapia, Alejandro, and McPhee, Derek J.

Subjects
*ANTIOXIDANTS, *HIGH performance liquid chromatography, *BACCHARIS, *CINNAMIC acid, *FLAVONOIDS
Abstract

The decoction of the local plant Baccharis grisebachii is used as a digestive, gastroprotective, external cicatrizing agent and antiseptic in Argentine. A lyophilized decoction (BLD) from the aerial parts of this plant was evaluated regarding its anti-ulcer, antioxidant and cytotoxic activities and the bioactivities were supported by UHPLC-MS metabolome fingerprinting which revealed the presence of several small bioactive compounds. The antioxidant properties were evaluated by DPPH, TEAC, FRAP and lipoperoxidation inhibition in erythrocytes methods, and the antibacterial activity was evaluated according to the Clinical and Laboratory Standards Institute (CLSI) guidelines. The BLD showed a moderate free radical scavenging activity in the DPPH (EC50 = 106 µg/mL) and lipid peroxidation in erythrocytes assays (67%, at 250 µg/mL). However, the BLD had the highest gastroprotective effect at a dose of 750 mg/kg with a ninety-three percent inhibition of damage through a mechanism that involve NO and prostaglandins using the ethanol-induced gastric damage in a standard rat model. On the other hand, BLD does not induce cytotoxic changes on human tumor and no-tumor cell lines at the concentrations assayed. Regarding the metabolomic analysis, thirty-one compounds were detected and 30 identified based on UHPLC-OT-MS including twelve flavonoids, eleven cinnamic acid derivatives, one coumarin, one stilbene and two other different phenolic compounds. The results support that the medicinal decoction of Baccharis grisebachii is a valuable natural product with gastroprotective effects and with potential to improve human health that opens a pathway for the development of important phytomedicine products. [ABSTRACT FROM AUTHOR]

Published
2019
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7. Bioactivity of Argentinean essential oils against permethrin-resistant head lice, Pediculus humanus capitis

Author

María Inés Picollo, Alicia Dora Rotman, Julio Alberto Zygadlo, Ariel Ceferino Toloza, and Fernando Biurrun

Subjects
biopesticides, Insecticides, fumigant activity, Chromatography, Gas, Insecta, medicine.drug_class, Myrtaceae, Argentina, medicine.disease_cause, Insecticidas, Insect Control, Article, Toxicology, Human Head Louse, Species Specificity, Phthiraptera, Verbenaceae, parasitic diseases, Infestation, Oils, Volatile, medicine, Pediculicide, Animals, Humans, Piojos Chupadores, Permethrin, Cinnamomum, Permetrina, biology, Chemotype, Pediculus humanus capitis, Essential Oils, Pediculus, General Medicine, Plants, Aceites Esenciales, biology.organism_classification, Head louse, Biopesticide, Insect Science, human head louse, Biological Assay, Control de Insectos, Argentinean plants, medicine.drug
Abstract

Infestation with the head louse, Pediculus humanus capitis De Geer (Phthiraptera: Pediculidae), is one of the most common parasitic infestation of humans worldwide. Traditionally, the main treatment for control of head lice is chemical control that is based in a wide variety of neurotoxic synthetic insecticides. The repeated overuse of these products has resulted in the selection of resistant populations of head lice. Thus, plant-derived insecticides, such as the essential oils seem to be good viable alternatives as some have low toxicity to mammals and are biodegradable. We determined the insecticidal activity of 25 essential oils belonging to several botanical families present in Argentina against permethrin-resistant head lice. Significant differences in fumigant activity against head lice were found among the essential oils from the native and exotic plant species. The most effective essential oils were Cinnamomum porphyrium, followed by Aloysia citriodora (chemotype 2) and Myrcianthes pseudomato, with KT 50values of 1.12, 3.02 and 4.09; respectively. The results indicate that these essential oils are effective and could be incorporated into pediculicide formulations to control head lice infestations once proper formulation and toxicological tests are performed. EEA La Rioja Fil: Toloza, Ariel Ceferino. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Científicas y Técnicas para la Defensa. Centro de Investigación de Plagas e Insecticidas; Argentina Fil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Cátedra de Química Orgánica; Argentina Fil: Biurrun, Fernando Noe. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria La Rioja; Argentina Fil: Rotman, Alicia. Universidad Nacional de Jujuy. Cátedra de Botánica General; Argentina Fil: Picollo, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Investigaciones Científicas y Técnicas para la Defensa. Centro de Investigación de Plagas e Insecticidas; Argentina

Published
2010

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