79 results on '"Arede P"'
Search Results
2. Current management of inherited retinal degenerations in Portugal (IRD-PT survey)
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Marques, João Pedro, Ferreira, Nuno, Moreno, Natacha, Marta, Ana, Vaz-Pereira, Sara, Estrela-Silva, Sérgio, Costa, José, Cardoso, Ana Rocha, Neves, Pedro, Duarte, Lilianne, Meira, Dália, Pires, Joana, Menezes, Carlos, Rodrigues, Filipa, Arede, Pedro, Coutinho, André, Cabral, Diogo, Coutinho, Inês, Ribeiro, Miguel, Macedo, Marta, Brito, Sérgio, Isidro, Filipe, Rodrigues, Filipa Gomes, Sousa, João Paulo Castro, Marques, Marco, Martins, Raquel, and Silva, Eduardo
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- 2024
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3. The socioeconomic epidemiology of inherited retinal diseases in Portugal
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Marta, Ana, Marques, João Pedro, Santos, Cristina, Coutinho-Santos, Luísa, Vaz-Pereira, Sara, Costa, José, Arede, Pedro, Félix, Raquel, Geada, Sara, Gouveia, Nuno, Silva, Rui, Baptista, Margarida, Lume, Miguel, Parreira, Ricardo, Azevedo Soares, Célia, Menéres, Maria João, Lemos, Carolina, and Melo Beirão, João
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- 2024
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4. Current management of inherited retinal degenerations in Portugal (IRD-PT survey)
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João Pedro Marques, Nuno Ferreira, Natacha Moreno, Ana Marta, Sara Vaz-Pereira, Sérgio Estrela-Silva, José Costa, Ana Rocha Cardoso, Pedro Neves, Lilianne Duarte, Dália Meira, Joana Pires, Carlos Menezes, Filipa Rodrigues, Pedro Arede, André Coutinho, Diogo Cabral, Inês Coutinho, Miguel Ribeiro, Marta Macedo, Sérgio Brito, Filipe Isidro, Filipa Gomes Rodrigues, João Paulo Castro Sousa, Marco Marques, Raquel Martins, and Eduardo Silva
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Inherited retinal degenerations ,Genetic testing ,Ophthalmic genetics ,Rare eye diseases ,Epidemiology ,Medicine ,Science - Abstract
Abstract Inherited retinal dystrophies/degenerations (IRDs) are the leading cause of visual impairment and incurable familial blindness in the Western world. Given the clinical and genetic heterogeneity, establishing a molecular diagnosis is especially relevant. The aim of this study was to perform the first nationwide survey to understand the prevalence and current management of IRDs in Portugal. A response was obtained from 26 healthcare providers (HCP) (76.5% response rate). Only 4 respondents reported not managing IRD patients. Most HCPs (68.1%) reported managing up to 100 patients, while three currently manage between 501 and 1000 patients. Based on the Portuguese population, an estimated IRD prevalence of 0.031%, i.e., about 1 in 3000 individuals, was calculated. In most HCPs (86.3%), most patients are adults, and non-syndromic retinitis pigmentosa is the most frequent diagnosis. Only 4 HCPs currently use the national, web-based IRD registry (IRD-PT). However, all but one respondent expressed interest in participating in such a registry. Genetic testing is available in 54.5%, with 58.3% HCPs reporting solved rates between 61–80%, but 4 to 9 months to get a genetic test result in 83.4% of cases. Based on this survey, the prevalence of biallelic RPE65-associated disease in Portugal is 0.00031%, i.e., approximately 1:300,000 individuals. Data from this study provide vital background information on national differences in the diagnosis and management of IRD patients. Nationwide implementation of the IRD-PT registry should be encouraged and supported to provide population-based reference data and to identify patients eligible for current and future therapies.
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- 2024
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5. Iris-Claw Anterior Chamber Phakic Intraocular Lens Explantation: A Case Series
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Sofia Cunha Teixeira, Pedro Martins, Teresa Pacheco, and Carlos Arede
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corneal endothelium ,intraocular lens implantation ,phakic intraocular lens ,Ophthalmology ,RE1-994 - Abstract
Purpose: To evaluate indications, clinic characteristics, and outcomes in a series of patients who underwent explantation of phakic intraocular lens (pIOL). Methods: Retrospective case series of patients who underwent iris-claw pIOL explantation in our institution from 2018 to 2022. Indications for explantation and visual and refractive outcomes were analyzed. Results: Twenty-three eyes of 14 patients underwent pIOL explantation with a mean time to explantation of 11.7 ± 3.4 years. The mean age at explantation was 46.0 ± 3.9 years. Sixteen Artisan and seven Artiflex IOL were explanted. The main indication for explantation was endothelial cell loss (n = 14) and morphometric significant alterations of endothelial cells other than endothelial cell count decline (n = 5). The mean corrected vision after explantation was 0.4 ± 0.4 logMAR, and around 70% of intervened patients achieved visual acuity of at least 0.3 logMAR (0.5 in decimal scale). Conclusions: In our group series, the main reason for the removal of pIOL was endothelial cell loss. This complication should be monitored and followed, so that early actions, namely IOL explantation, can be performed to avoid the development of deterioration requiring corneal transplantation. In fact, loss of follow-up, found in several cases for many years, continues to be a serious problem.
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- 2024
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6. The socioeconomic epidemiology of inherited retinal diseases in Portugal
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Ana Marta, João Pedro Marques, Cristina Santos, Luísa Coutinho-Santos, Sara Vaz-Pereira, José Costa, Pedro Arede, Raquel Félix, Sara Geada, Nuno Gouveia, Rui Silva, Margarida Baptista, Miguel Lume, Ricardo Parreira, Célia Azevedo Soares, Maria João Menéres, Carolina Lemos, and João Melo Beirão
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Inherited retinal diseases ,Epidemiology ,Economics ,Social ,Medicine - Abstract
Abstract Background Inherited retinal diseases (IRDs) are a group of rare degenerative disorders of the retina that can lead to blindness from birth to late middle age. Knowing the target population and its resources is essential to better plan support measures. The aim of this study was to evaluate the socioeconomic characteristics of regions in Portugal where IRD patients reside to inform the planning of vision aid and rehabilitation intervention measures. Results This study included 1082 patients from 973 families, aged 3 to 92 years, with a mean age of 44.8 ± 18.1 years. Patients living with an IRD were identified in 190 of the 308 municipalities. According to this study, the estimated IRD prevalence in Portugal was 10.4 per 100,000 inhabitants, and by municipalities, it ranged from 0 to 131.2 per 100,000 inhabitants. Overall, regions with a higher prevalence of IRD have a lower population density (r=-0.371, p
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- 2024
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7. Corrigendum: Examination of critical factors influencing ruminant disease dynamics in the Black Sea Basin
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Margarida Arede, Daniel Beltrán-Alcrudo, Jeyhun Aliyev, Tengiz Chaligava, Ipek Keskin, Tigran Markosyan, Dmitry Morozov, Sarah Oste, Andrii Pavlenko, Mihai Ponea, Nicolae Starciuc, Anna Zdravkova, Eran Raizman, Jordi Casal, and Alberto Allepuz
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Black Sea ,surveillance and control ,ruminants ,transboundary animal diseases ,zoonoses ,Veterinary medicine ,SF600-1100 - Published
- 2024
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8. Suitability of anthrax (Bacillus anthracis) in the Black Sea basin through the scope of distribution modelling.
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Margarida Arede, Alberto Allepuz, Daniel Beltran-Alcrudo, Jordi Casal, and Daniel Romero-Alvarez
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Medicine ,Science - Abstract
The Black Sea basin has a strategic geographic location bridging Asia and Europe and depends on traditional livestock practices for their local economies. Anthrax, a zoonotic bacterial disease caused by Bacillus anthracis, poses a significant global threat impacting public health, food security, pastoralist communities, and national economies. The disease is endemic or sporadic in the Black Sea basin, however, the study of its distribution has seldom been addressed, despite its burden and the presence of historical B. anthracis burial sites in the region. The viability of B. anthracis in a particular region is going to be influenced by multiple environmental factors, such as soil composition, climate, vegetation, and host abundance. For characterizing the potential distribution of B. anthracis in the Black Sea basin and assessing the potential for anthrax outbreaks, we applied an ecological niche modelling framework using the Maxent algorithm. This machine-learning algorithm models species distributions based on presence data and background information from a specified calibration region. We analyzed multiple variable combinations and proposed a novel approach for interpreting in-risk anthrax areas. Our findings underscored the importance of host abundance to the anthrax dynamics in the region. We identified anthrax-suitable areas spanning central and eastern Türkiye, Armenia, southern Georgia, southern Russia, Bulgaria, southern and eastern Romania, Hungary, Moldova, and southern Ukraine, which align with findings from previous global and regional studies on the potential suitability of anthrax. The insights gained from our research may help to develop targeted interventions, such as awareness and educational campaigns about anthrax, supervision of anthrax-infected carcasses disposal, and the promotion of livestock vaccination in high-risk areas. Additionally, these results can inform policies to mitigate the spread of anthrax in pastoralist communities in the Black Sea basin and foster collaboration between veterinary and public health entities on anthrax control.
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- 2024
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9. Writing a Novel with Roma Primary School Children: Tensions in Disrupting Aetonormativity
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Dobson, Tom, Stephenson, Lisa, and De Arede, Ana
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Story Makers Press (SMP) is a University-based publisher which co-constructs stories with under-represented groups of children in order to diversify representation in children's literature and disrupt the way adult perceptions of normality pattern children's literature (aetonormativity). In this paper we analyse six drama and creative writing workshops run by SMP with Czech and Slovak Roma children from an inner city primary school in the north of England to co-construct a story about climate change. Our analysis identifies how in developing the story, the children were often reluctant to draw upon their funds of knowledge relating to their Roma backgrounds, instead Westernising their protagonists and settings. We also explore how the children disrupt aetonormativity by interweaving magical elements into realistic narrative about climate change in order to establish a genre of magical realism. Finally, we identify how this genre of magical realism is problematic when considering stereotypical depictions of Roma characters in children's literature and how changes were made to our story in light of a critical race theory reading of the first draft. As well as helping SMP to refine its processes, this analysis suggests that minority groups such as Roma need to be able to draw upon more literary representations of Roma in order to shape their creative outputs and that the curriculum needs to focus on developing children's critical responses to the representation of minority ethnic groups in children's literature.
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- 2021
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10. Examination of critical factors influencing ruminant disease dynamics in the Black Sea Basin
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Margarida Arede, Daniel Beltrán-Alcrudo, Jeyhun Aliyev, Tengiz Chaligava, Ipek Keskin, Tigran Markosyan, Dmitry Morozov, Sarah Oste, Andrii Pavlenko, Mihai Ponea, Nicolae Starciuc, Anna Zdravkova, Eran Raizman, Jordi Casal, and Alberto Allepuz
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Black Sea ,surveillance and control ,ruminants ,transboundary animal diseases ,zoonoses ,Veterinary medicine ,SF600-1100 - Abstract
IntroductionRuminant production in the Black Sea basin (BSB) is critical for national economies and the subsistence of rural populations. Yet, zoonoses and transboundary animal diseases (TADs) are limiting and threatening the sector. To gain a more comprehensive understanding, this study characterizes key aspects of the ruminant sector in nine countries of the BSB, including Armenia, Azerbaijan, Belarus, Bulgaria, Georgia, Moldova, Romania, Türkiye, and Ukraine.MethodsWe selected six priority ruminant diseases (anthrax, brucellosis, Crimean Congo haemorrhagic fever (CCHF), foot-and-mouth disease (FMD), lumpy skin disease (LSD), and peste des petits ruminants (PPR)) that are present or threaten to emerge in the region. Standardized questionnaires were completed by a network of focal points and supplemented with external sources. We examined country and ruminant-specific data such as demographics, economic importance, and value chains in each country. For disease-specific data, we analysed the sanitary status, management strategies, and temporal trends of the selected diseases.Results and discussionThe shift from a centrally planned to a market economy, following the collapse of the Soviet Union, restructured the ruminant sector. This sector played a critical role in rural livelihoods within the BSB. Yet, it faced significant challenges such as the low sustainability of pastoralism, technological limitations, and unregistered farms. Additionally, ruminant health was hindered by informal animal trade as a result of economic factors, insufficient support for the development of formal trade, and socio-cultural drivers. In the Caucasus and Türkiye, where diseases were present, improvements to ruminant health were driven by access to trading opportunities. Conversely, European countries, mostly disease-free, prioritized preventing disease incursion to avoid a high economic burden. While international initiatives for disease management are underway in the BSB, there is still a need for more effective local resource allocation and international partnerships to strengthen veterinary health capacity, protect animal health and improve ruminant production.
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- 2023
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11. Charles Bonnet syndrome in age-related macular degeneration – prevalence and clinical features in a Portuguese population
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Mariana Portela, Pedro Arede, Maria Picoto, and Fernanda Vaz
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Charles Bonnet syndrome ,Vision, low ,Macular degeneration ,Hallucinations ,Geographic atrophy ,Ophthalmology ,RE1-994 - Abstract
ABSTRACT Objective: Age-related macular degeneration (AMD) is the most prevalent cause of irreversible visual loss in the developed world. In late stages, it may lead to extremely low visual acuities, especially when associated with geographic atrophy or choroidal neovascularization. According to recent literature, Charles Bonnet syndrome (CBS) may be a rather common feature of late AMD. Methods: One hundred patients with late-stage age-related macular degeneration were actively asked whether they had symptoms of Charles Bonnet syndrome. Those that answered positively underwent a comprehensive questionnaire about the details of the visual hallucinations. Results: The following factors were significantly associated with Charles Bonnet syndrome: older age (+6.3 years; p=0.003), lower visual acuity in the better eye (Charles Bonnet Syndrome Group: 0.11; Non-Charles Bonnet Syndrome Group: 0.42; p=0.005) and female sex (Charles Bonnet Syndrome Group: 88%; Non-Charles Bonnet Syndrome Group: 43%; p=0.02). The visual hallucinations occurred mainly straight ahead (n=5), once per day (n=4), at no particular time (n=6), lasted some minutes (n=5), and disappeared after blinking (n=3) or looking away (n=3). The majority of patients lived alone (n=7), had not told anyone about the hallucinations (n=6), and associated the episodes with severe distress (n=5). Conclusion: Charles Bonnet syndrome was fairly prevalent in this late-stage age-related macular degeneration population. Our sample shows the importance of directly asking subjects about Charles Bonnet syndrome since they are often reluctant to admit to having visual hallucinations. Reassurance about its benignity is crucial to improve their quality of life.
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- 2023
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12. Reduced acquisition time for thallium myocardial perfusion imaging with large field cadmium-zinc-telluride SPECT/CT cameras: An equivalence study
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Bonnefoy, P. B., Janvier, L., Arede, C., Drouet, C., Harami, D., Marque, S., and Ahond-Vionnet, R.
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- 2022
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13. Exploring the Effects of LED Lighting Training Program on Motor Performance among Young Athletes
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Arede, Jorge, Carvalho, Márcio, Esteves, Pedro, de las Heras, Bernat, and Leite, Nuno
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The aim of this study was to examine the effects of a BATAK Pro™ training program in combination with regular sport-specific training as compared with sport-specific training alone on motor performance among young athletes. Twenty-two athletes (aged 11-16 years) were recruited and randomly assigned to either an active control group or BATAK training group. The BATAK training program consisted of 2-3 sets of 4-5 exercises, biweekly for 12-weeks. The assessment of motor performance included upper limb movement speed, agility, reactive agility, acceleration, sprinting, and Y-Balance test. Within-group analyses revealed performance increases in the 10-m sprint test (-2.6%), and in Y-Balance test variables, specifically in anterior direction (4.0-5.4%), posteromedial direction (6.6-8.0%) and in posterolateral direction (10.7-14.6%) in the BATAK group. This study reports for the first time that the use of LED lighting devices in addition to sport-specific training promotes increases in motor skills, particularly in dynamic stability. More studies are needed to confirm whether the training-induced benefits of this novel performance tool are significantly better as compared to other approaches, and whether these results can be translated into on-field performance outcomes, not only in terms of critical motor development but also in a meaningful increase of creative actions.
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- 2021
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14. Disrupting Aetonormativity: Involving Children in the Writing of Literature for Publication
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Dobson, Tom, Stephenson, Lisa, and De Arede, Ana
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Literary criticism of children's literature asserts a one-directional view of power with the adult writer constructing the child reader. Using "aetonormativity"-- adult perceptions of normality -- this paper explores what happens when children co-construct publishable fiction. Our analysis of drama and creative writing workshops shows how whilst we were interested in developing the story of the protagonist, the children wanted to develop a gaming narrative. As a community of writers, we constructed a "hybrid" text which, unlike GameLit, explores the relationship between the protagonist and gaming, whilst providing positive portrayal of gaming. As the children became invested in the fiction, they became editors and revisions were taken on board. The paper concludes that involving children in writing children's literature can result in texts which disrupt aetonormativity by representing lived experiences. The paper also acknowledges that that further research is needed to explore how other children respond to such texts.
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- 2021
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15. RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression
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Stuart W. McKellar, Ivayla Ivanova, Pedro Arede, Rachel L. Zapf, Noémie Mercier, Liang-Cui Chu, Daniel G. Mediati, Amy C. Pickering, Paul Briaud, Robert G. Foster, Grzegorz Kudla, J. Ross Fitzgerald, Isabelle Caldelari, Ronan K. Carroll, Jai J. Tree, and Sander Granneman
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Science - Abstract
Regulatory small RNA (sRNA) interact with mRNAs to regulate their stability, transcription, and translation via diverse mechanisms. Here, McKellar et al. apply RNase IIICLASH of multi-drug resistant Staphylococcus aureus under different culture conditions to link the network of RNA-RNA interactions to environmental conditions and find that the production of small membrane-permeabilizing toxins is strongly regulated by sRNAs.
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- 2022
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16. The RNA-bound proteome of MRSA reveals post-transcriptional roles for helix-turn-helix DNA-binding and Rossmann-fold proteins
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Liang-Cui Chu, Pedro Arede, Wei Li, Erika C. Urdaneta, Ivayla Ivanova, Stuart W. McKellar, Jimi C. Wills, Theresa Fröhlich, Alexander von Kriegsheim, Benedikt M. Beckmann, and Sander Granneman
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Science - Abstract
RNA-binding proteins play key roles in controlling gene expression in many organisms. Here, Chu et al. identify hundreds of RNA-binding proteins in methicillin-resistant Staphylococcus aureus, and show that a major transcription factor uses its helix-turn-helix domain to bind RNAs near intrinsic transcription terminators.
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- 2022
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17. Influence of Two Different Competition Models on Physical Performance in Under-13 Basketball Players: Analysis Considering Maturity Timing
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Ricardo André Birrento-Aguiar, Jorge Arede, Nuno Leite, Francisco Javier García-Angulo, José Pino-Ortega, and Enrique Ortega-Toro
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maturation ,growth ,development ,team sports ,competition ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The rules of team sport have been influenced by professional competitions without considering all the factors that differentiate children and adolescents from adults. The aim of this study was to analyse the performance of kinematic variables in two different types of tournaments and the influence of somatic maturation on performance in young basketball players. Thirty-seven under-13 male basketball players (age = 12.91 ± 0.57 years) were selected by four southeast Spanish teams to participate in two different tournaments. On the first day, the tournament was played according to the rules of the Spanish Basketball Federation (FEB) for under-14 players, and on the second day, the tournament was played according to modified rules (Modified Tournament). In this tournament, the height of the basket was lowered to 2.90 m; the three-point line was a rectangle that was 4 m from the basket.The following kinematic variables were analysed: Acceleration (n), Deceleration (n), Maximum Acceleration Speed (km/h), Maximum Deceleration Speed (km/h), Acceleration Meters Covered (m), Deceleration Meters Covered (m), Number of Sprints (n), Sprint Meters Covered (m), Maximum Sprint Speed, and Player Load (n). The results showed no significant differences in player performance between the tournaments. However, significant differences in performance (p < 0.05) were found in players at different stages of maturation. Early maturity players showed the best performance in the kinematic variables in both tournaments; because of this, there should be a modification of the rules and organisation of competitions by bio-banding. It can be concluded that there were no significant differences in the kinematic variables between the two tournaments. However, when comparing maturation timing, there tends to be a group effect.
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- 2023
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18. Train Smarter, Play More: Insights about Preparation and Game Participation in Youth National Team
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Arede, Jorge, Ferreira, António Paulo, Esteves, Pedro, Gonzalo-Skok, Oliver, and Leite, Nuno
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Purpose: The aim of this study was to analyze the relationship between physical preparation, training sessions (TS) and friendly matches' (FM) demands, and playing status during European Championship (EC). Method: Twelve under-16 (U-16) basketball players performed physical (jumping, agility, aerobic fitness, and lower limb asymmetry index [ASI]) tests prior to attending the national team training camp. External training load was assessed using the WIMU PRO System put in place during TS (n = 19) and FM (n = 3), integrating the national team preparation. Perceptual response (RPE), muscle soreness (DOMS), and game-related statistics were also collected. Playing status during the U-16 EC (starters vs nonstarters) were taken into consideration to analyze the between-subjects differences across all variables. A stepwise discriminant analysis was computed to identify the construct that best differentiated the players' playing status (starters vs nonstarters) during the EC. Results: The starters were characterized by lower movement demands in both TS (ES: -0.02 to -1.26) and FM (ES: -0.03 to -1.94), however, outscored nonstarters in most FM-related statistics (ES: 0.10 to 3.62), with exception to blocks and rebounds. The number of high-intensity decelerations during FM (p [less than or equal to] 0.05), but also training DOMS, number of steals, efficiency, minutes during FM, and countermovement jump (CMJ) (p [less than or equal to] 0.01) substantially discriminated the playing status over the course of the EC. Conclusion: Game-related statistics obtained in FM seem to be a determinant aspect that increases the probability to be the starter during the EC.
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- 2020
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19. RNase III CLASH in MRSA uncovers sRNA regulatory networks coupling metabolism to toxin expression
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McKellar, Stuart W., Ivanova, Ivayla, Arede, Pedro, Zapf, Rachel L., Mercier, Noémie, Chu, Liang-Cui, Mediati, Daniel G., Pickering, Amy C., Briaud, Paul, Foster, Robert G., Kudla, Grzegorz, Fitzgerald, J. Ross, Caldelari, Isabelle, Carroll, Ronan K., Tree, Jai J., and Granneman, Sander
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- 2022
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20. The RNA-bound proteome of MRSA reveals post-transcriptional roles for helix-turn-helix DNA-binding and Rossmann-fold proteins
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Chu, Liang-Cui, Arede, Pedro, Li, Wei, Urdaneta, Erika C., Ivanova, Ivayla, McKellar, Stuart W., Wills, Jimi C., Fröhlich, Theresa, von Kriegsheim, Alexander, Beckmann, Benedikt M., and Granneman, Sander
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- 2022
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21. Performance indicators and functional adaptive windows in competitive cyclists: effect of one-year strength and conditioning training programme
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Leonardo Cesanelli, Achraf Ammar, Jorge Arede, Julio Calleja-González, and Nuno Leite
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cycling performance ,functional power ,strength ,endurance ,performance analysis ,Sports medicine ,RC1200-1245 ,Biology (General) ,QH301-705.5 - Abstract
Changes and relationships between cycling performance indicators following a one-year strength and conditioning training have not been totally clarified. The aims of this study are to investigate (i) the effect of a combined one-year strength and conditioning training programme on performance indicators and the possible relationships between these indicators, and (ii) the existence of possible endurance-functional-adaptive windows (EFAWs) linked to changes in muscular strength and body composition markers. Functional and lactate threshold power (FTP and LTP), maximal strength (1RM) and body composition (body mass index [BMI], body cell mass [BCM] and phase angle [PA]) were measured at the beginning and the end of a one-year strength and conditioning training programme of thirty cyclists. Correlations, differences, and predictive analysis were performed among parameters. Significant differences were found between pre- and post-conditioning programme results for FTP, LTP, 1RM (p < 0.0001) and BCM (p = 0.038). When expressed as power output (W), FTP and LTP were significantly correlated with 1RM (r = 0.36, p = 0.005 and r = 0.37, p = 0.004, respectively), body mass (r = 0.30 and p = 0.02), BCM (r = 0.68, p < 0.001) and PA (r = 0.42 and 0.39, respectively and p < 0.001). When expressed as W·kg-¹, these power thresholds were strongly correlated with body mass (r = -0.56 and -0.61, respectively) and BMI (r = -0.57 and -0.61 respectively) with p < 0.001. Predictive polynomial regressions revealed possible endurance and strength adaptation zones. The present findings indicated beneficial impacts of one-year strength and conditioning training on cycling performance indicators, confirmed the correlation between performance indicators, and suggested the existence of different EFAWs. Strategies aiming to improve performance should consider cyclist characteristics and performance goals to achieve EFAWs and thereby enhance cycling performance.
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- 2021
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22. First Experience of an Undergraduate Dental Student with a Reciprocating System in Simulated Root Canals—A Pilot Study
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Ana Rita Arede, Inês Ferreira, Ana Cristina Braga, and Irene Pina-Vaz
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dental education ,root canal preparation ,root canal obturation ,root canal therapy ,undergraduate student ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Rotary instrumentation has been proposed in undergraduate teaching. The aim of this study was to evaluate student’s performance, through the obturation quality and treatment time, in a sequential range of L-simulated root canals. A senior undergraduate dental student sequentially prepared randomly numbered canals from 1 to 40, with the WaveOne Gold glider and primary file, according to the manufacturer instructions. A gutta-percha cone matched with the finishing instrument and epoxy resin-based sealer (AH Plus) was selected for the obturation. Three independent observers evaluated the obturation quality according to both density and length. Active, total instrumentation and obturation times were also measured. Statistical analysis was obtained by Mann–Whitney and Kruskal–Wallis tests with a significance level of p < 0.05. The quality of the obturation was independent of the number of prepared canals with adequate length and density in 87.5% of the prepared canals. Both active and total instrumentation, as well as obturation times, reduced significantly as the number of the prepared canals by the student increased (p ˂ 0.05). The use of WaveOne Gold instrumentation and matched cone obturation by an inexperienced operator provided an adequate obturation quality in most of the curved simulated canals. The working time was significantly reduced through a short learning curve.
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- 2023
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23. INCENTIVES AND RESTRAINS RELATED TO THE DEVELOPMENT OF A WINE TOURISM DESTINATION: A NEW INSTITUTIONAL ECONOMICS APPROACH
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Tissiane Schmidt Dolci, Vander Valduga, Artur Fernando Arede Correia Cristovão, Leonardo Xavier da Silva, and Marcelino de Souza
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wine tourism ,new institutional economics ,institutions ,tourism development ,Social sciences (General) ,H1-99 - Abstract
This paper aims at analysing the way institutions, under the approach of New Institutional Economics, incentivize or restrict the development of a wine tourism destination. This is a case study conducted in Vale dos Vinhedos, Rio Grande do Sul, Brazil, which is the main wine tourism destination in the country. A documental analysis was held along with interviews with 13 representative organizations (public and private) of wine and tourism sectors in the region. In the study, it was observed that wine tourism in Vale dos Vinhedos, lacks formal institutions, being solidly based on informal institutions, in other words, cultural region’s patterns. Additionally, the entry of new tourism players, with a different mindset, creates conflicts and institutional pressure, especially related to land usage. It can be observed that leadership structures connected to these sectors have put effort to promote the destination. However, there is little formal institutional incentive. Thus, to solve these bottlenecks, it is recommended that the formulation of incentive policies be coherent with the informal institutional structure of the region, that they support local entrepreneurship, aiming at wine tourism dynamization in small properties, the definition of a shared destiny view and the roles of different segments of governance.
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- 2021
24. Hyponatremia in Cancer Patients Hospitalized in a Palliative Care Department: A Cross-Sectional Analysis
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José Ferraz Gonçalves, Mariana Brandão, Ana Arede, Bárbara Prucha, Inês Grilo, Susete Freitas, Isabel Costa, Olímpia Martins, and Vânia Araújo
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Hyponatremia ,Neoplasms/complications ,Palliative Care ,Medicine ,Medicine (General) ,R5-920 - Abstract
Introduction: Hyponatremia is frequent in cancer patients, as many studies carried out in these patients have shown. However, there are only a few studies carried out at the end of life and in palliative care. The aim of this study was to determine the prevalence of hyponatremia in cancer patients in the palliative care department of an oncology center and its association with survival. Material and Methods: The study included the first 300 patients hospitalized in the palliative care department in 2017. Survival was measured from the day of hospitalization until death. Results: Serum sodium was measured in 170 (59%) patients. The median serum concentration was 135 mmol/L (109 to 145). Among 91 (54%) patients, serum sodium was within the normal range, 59 (35%) had mild hyponatremia, 13 (8%) had moderate and seven (4%) had profound hyponatremia. The median survival was 13 days (1 to 1020). Serum sodium was not significantly associated with survival (p = 0.463). Regarding other variables, the Eastern Cooperative Oncology Group performance status was significantly associated with survival, while gender, age, primary cancer and number of metastatic sites were not. Conclusion: Hyponatremia is common in cancer patients receiving palliative care but did not seem to influence survival.
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- 2022
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25. The effects of a sled push at different loads on 20 metre sprint time in well-trained soccer players
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Nick Grimes, Jorge Arede, Benjamin Drury, Steve Thompson, and John Fernandes
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Sports ,GV557-1198.995 ,Sports medicine ,RC1200-1245 - Abstract
This study determined the effects of a single sled push at different loads on sprint performance in competitive male soccer players. Twenty male competitive outfield soccer players (age 19.6±1.3y, body mass 73.6±8.2kg) were split into experimental (n=10) and control groups. In the experimental group, 20m linear sprint time was measured immediately before and 5, 6 and 7minutes after the sled push with either 50 or 100% body mass. The control group performed the 20m sprints only. A repeated measures ANOVA comparing control and experimental groups revealed no effects of time, group or time by group interaction for either experimental condition (all P>0.05). The repeated measures ANOVA compared the experimental conditions revealed effects of time (P=0.034) and group (P=0.002), but not time by group (P>0.05). The effects sizes demonstrated within group effects on sprint time that were small to moderate (-0.26 to 0.71) and trivial to small (-0.31 to 0.09) for the 50% and 100% body mass condition, respectively. These findings demonstrate that a sled push has no significant effect on 20 m sprint time in competitive footballers. If coaches continue to prescribed a sled push before sprinting, a single 15 m push with 50% body mass could have positive benefits.
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- 2021
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26. Post neoadjuvant HER2 treatment: real world data from a multicentric cohort
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P. Luz, I. Fernandes, R. Diaz Acedo, S. Gamez Casado, E. Campoa, L. Alves, A.J. Arede, I. Lomares, J. Baena Cañada, J. Magalhães, A. Fernandes, J.G. Costa, and B. Gosalbez
- Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2021
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27. The evaluation of tumor-infiltrating lymphocytes (TILs) in early breast cancer: differences between histologic subtypes in a Portuguese cohort
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P. Luz, I. Fernandes, A.J. Arede, E. Campoa, L. Alves, J.L. Enrique Morera, B. Gosalbez, J.G. Costa, and A. Fernandes
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Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Published
- 2021
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28. The Influence of Contextual Aspects in Talent Development: Interaction Between Relative Age and Birthplace Effects in NBA-Drafted Players
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Nuno Leite, Jorge Arede, Ximing Shang, Julio Calleja-González, and Alberto Lorenzo
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environmental factors ,talent development ,date of birth ,place of birth ,interaction ,selection ,Sports ,GV557-1198.995 - Abstract
The aims of this study were two-fold: (1) to inspect separately for the relative age and birthplace effects for players selected in the National Basketball Association (NBA) draft; (2) to explore the interaction among these factors and analyse this interaction in players' career performance. The database was obtained from the official records of the players (n = 1,738), who were selected during the annual editions of the NBA Draft from 1990 to 2019. The participants' date of birth was analyzed according to the month of birth and divided into four quartiles. The place of birth was compared to the distribution of the general population' places of birth based on different communities' sizes. Chi-square analysis were used to determine if the relative age and birthplace of the players drafted differed in any systematic way from official census population distributions. Cluster analysis and standardized residuals were calculated to analyse the interaction among the contextual factors and the players' career performance. The data revealed that early-born players (Q1 and Q2) were over-represented. Moreover, players born in smaller cities (
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- 2021
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29. A Multi-Block Multivariate Analysis to Explore the Influence of the Somatic Maturation in Youth Basketball
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Jorge Arede, Irene Oliveira, Miguel-Angel Ángel Gomez, and Nuno Leite
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talent ,development ,puberty ,performance analysis ,identification ,growth ,Psychology ,BF1-990 - Abstract
The aim of this study was to examine the influence of somatic maturation in anthropometric, physical, and game-related variables in youth basketball age groups under-13 (U-13) and under-15 (U-15). One-hundred and eighty-five basketball players performed anthropometrical and physical tests during a non-official youth basketball tournament. Predicted maturity offset (MO) and game-related variables were also analyzed. Cluster analysis was used to analyze the between-maturation status differences in all parameters in each age group. Also, regularized generalized canonical correlation analysis (RGCCA) was used to assess relative contributions of maturational, physical, and game-related variables within each age group. Based on MO, two different clusters were identified within each age category. Greater differences in MO were identified among U-13 clusters than among U-15 clusters. No significant differences were observed between clusters in terms of physical and game-related variables. High correlations between maturational, physical, and game-related variables (i.e., points scored, field goals attempted, and rebounds) were found for boys. In girls, different trends in terms of correlations were observed. The strongest association between blocks was observed between physical tests and game-related variables in all age categories, except for U-15 girls. Knowing and identifying performance profiles according to biological age is of upmost importance since it allows the coach to create challenging situations adjusted to the individual’s needs.
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- 2021
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30. The effects of maturity matched and un-matched opposition on physical performance and spatial exploration behavior during youth basketball matches.
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Jorge Arede, Sean Cumming, David Johnson, and Nuno Leite
- Subjects
Medicine ,Science - Abstract
The aim of this study was analyze the effect of playing against biological matched and un-matched opposition, on physical performance and spatial exploration behavior of youth basketball players. Thirty under-14 to 16 basketball players were assigned to different teams according to maturity status (Pre-, Mid-, and Post-Peak Height Velocity [PHV]), and participated in basketball matches against matched (same maturity status), and un-matched (different maturity status) opposition. Maturity status was estimated considering the percentage of predicted adult height. Workload data was collected via inertial devices (IMUs) and Ultra-Wide Band (UWB)-based system. Heart rate was recorded with individual HR monitors. The Pre-PHV performed significantly more accelerations and decelerations and explored more space against matched opposition. Against un-matched opposition, the Pre-PHV presented higher average speed, body impacts, and Player Load. Both Mid- and Post-PHV covered more distance against matched opposition than against Pre-PHV. Games against Pre-PHV involved lower distance covered, average speed, Player Load, and higher accelerations and decelerations, than against Mid- and Post-PHV. The Pre-PHV athletes performed a higher number of accelerations and decelerations comparing to the Mid and Post-PHV players. Also, a significant interaction effect (group x time) was found in distance covered, average speed, body impacts, and Player Load. The type of opposition influenced physical performance and spatial exploration behavior during basketball matches, particularly of less-mature players. Based on present findings, practitioners can select the most suitable game format, considering the physical, technical, tactical, and psychological development needs, individualizing training stimulus.
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- 2021
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31. Potencial energético do resíduo do despolpamento doaçaí sob diferentes condições de estocagem
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Raphael de Souza Costa Arede, Eder Souto Batista, Jefferson Bezerra Bezerra, Tiago Marcolino de Souza, and Lina Bufalino
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umidade ,densidade básica ,materiais voláteis ,carbono fixo ,cinzas ,Agriculture ,Agriculture (General) ,S1-972 ,Environmental sciences ,GE1-350 - Abstract
A investigação da qualidade biomassa na condição fresca e após estocagem no ambienteé necessária para subsidiar seu aproveitamento para geração de energia. Na Amazônia, o resíduoproduzido a partir do despolpamento do açaí se destaca pela ampla disponibilidade. O objetivo dotrabalho foi avaliar se os diferentes métodos e locais de acondicionamento modificamaspropriedades físicas, químicas e energéticas dos resíduos do açaí e seu potencial comfinsenergéticos. Os resíduos foramcoletados emMacapá, estado do Amapá, emseis diferentescondições: uma amostra fresca, obtida após despolpamento, e cinco estocadas emdiferentescondições ambientais. Após a despolpa, o resíduo do açaí apresentou umidade de 1 03,8%, mas aestocagem resultou em secagem natural, reduzindo esta propriedade para até 1 2,3%. Em comparaçãoao resíduo fresco (0,71 9 g cm-3), a densidade básica da biomassa dispersa emterreno baldiodiminuiu significativamente (0,279 g cm-3), o que aumenta os custos de transporte e reduz orendimento da combustão e pirólise. O teor de voláteis aumentou de 65,29%para até 75,62%,enquanto o carbono fixo diminuiu de 34,70% para até 23,09% e as cinzas de 1 ,81 % para até 1 ,24%,quando os resíduos foramestocados. Tais modificações sugerema decomposição de parte doscomponentes químicos doresíduodoaçaí que se tornamvoláteis oulixiviáveis. Comoconsequência, a estocagemdiminuiu o poder calorífico e a densidade energética dos resíduos.Concluiu-se que a estocagem do resíduo do açaí em qualquer condição, com exceção da diminuiçãoda umidade, prejudicou seu potencial energético.
- Published
- 2020
32. Mechanical, Physiological, and Perceptual Demands of Repeated Power Ability Lower-Body and Upper-Body Tests in Youth Athletes: Somatic Maturation as a Factor on the Performance
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Jorge Arede, Nuno Leite, Ben Bradley, Marc Madruga-Parera, Eduardo Saéz de Villarreal, and Oliver Gonzalo-Skok
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technology ,performance analysis ,maximal power output ,strength ,high-intensity efforts ,Psychology ,BF1-990 - Abstract
This study aims (a) to assess and compare the acute mechanical, physiological, and perceptual demands induced by a lower and upper body repeated power ability (RPA) protocols, and (b) to examine how the somatic maturation could predict training response in RPA. Thirteen young male basketball players (chronological age = 15.2 ± 1.1 years; height = 173.8 ± 9.5 cm; body mass = 71.7 ± 18.3 kg) were selected to perform the parallel Back Squat (BS), and Bench Press (BP) RPA protocols (3 blocks of 5 sets of 5 repetitions with 30 s and 3 min of passive recovery between sets and blocks, respectively). Mean propulsive power (MPP), accelerometer-based data, cardio-respiratory data, blood lactate, rate of perceived exertion (RPE) and muscle soreness were recorded. Somatic maturation was estimated according to the Khamis and Roche method. On the BS protocol, the mean oxygen uptake (VO2), heart rate (HR), and RPE were 1006.33 ± 481.85 ml/min., 133.8 ± 12.5 bpm, and 6.14 ± 0.98 A.U., while on the BP protocol, were 684.6 ± 246.3 ml/min., 96.1 ± 10.4 bpm, and 5.08 ± 1.44 A.U., respectively. Significant between-blocks differences were found for MPP, RPE, and blood lactate for both exercises. The BS implies higher cardio-respiratory and perceptual demands, though lower power production fluctuation and movement variability than the BP. The somatic maturation was a strong predictor of RPA-derived variables in BS. The MPP during all protocol, and the MPP during the Best Set were significant predictable by somatic maturation in both exercises. Mechanical, physiological and perceptual training demands are exercise and maturation dependent.
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- 2020
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33. The domesticated transposase ALP2 mediates formation of a novel Polycomb protein complex by direct interaction with MSI1, a core subunit of Polycomb Repressive Complex 2 (PRC2).
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Christos N Velanis, Pumi Perera, Bennett Thomson, Erica de Leau, Shih Chieh Liang, Ben Hartwig, Alexander Förderer, Harry Thornton, Pedro Arede, Jiawen Chen, Kimberly M Webb, Serin Gümüs, Geert De Jaeger, Clinton A Page, C Nathan Hancock, Christos Spanos, Juri Rappsilber, Philipp Voigt, Franziska Turck, Frank Wellmer, and Justin Goodrich
- Subjects
Genetics ,QH426-470 - Abstract
A large fraction of plant genomes is composed of transposable elements (TE), which provide a potential source of novel genes through "domestication"-the process whereby the proteins encoded by TE diverge in sequence, lose their ability to catalyse transposition and instead acquire novel functions for their hosts. In Arabidopsis, ANTAGONIST OF LIKE HETEROCHROMATIN PROTEIN 1 (ALP1) arose by domestication of the nuclease component of Harbinger class TE and acquired a new function as a component of POLYCOMB REPRESSIVE COMPLEX 2 (PRC2), a histone H3K27me3 methyltransferase involved in regulation of host genes and in some cases TE. It was not clear how ALP1 associated with PRC2, nor what the functional consequence was. Here, we identify ALP2 genetically as a suppressor of Polycomb-group (PcG) mutant phenotypes and show that it arose from the second, DNA binding component of Harbinger transposases. Molecular analysis of PcG compromised backgrounds reveals that ALP genes oppose silencing and H3K27me3 deposition at key PcG target genes. Proteomic analysis reveals that ALP1 and ALP2 are components of a variant PRC2 complex that contains the four core components but lacks plant-specific accessory components such as the H3K27me3 reader LIKE HETEROCHROMATION PROTEIN 1 (LHP1). We show that the N-terminus of ALP2 interacts directly with ALP1, whereas the C-terminus of ALP2 interacts with MULTICOPY SUPPRESSOR OF IRA1 (MSI1), a core component of PRC2. Proteomic analysis reveals that in alp2 mutant backgrounds ALP1 protein no longer associates with PRC2, consistent with a role for ALP2 in recruitment of ALP1. We suggest that the propensity of Harbinger TE to insert in gene-rich regions of the genome, together with the modular two component nature of their transposases, has predisposed them for domestication and incorporation into chromatin modifying complexes.
- Published
- 2020
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34. Loss of Kat2a enhances transcriptional noise and depletes acute myeloid leukemia stem-like cells
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Ana Filipa Domingues, Rashmi Kulkarni, George Giotopoulos, Shikha Gupta, Laura Vinnenberg, Liliana Arede, Elena Foerner, Mitra Khalili, Rita Romano Adao, Ayona Johns, Shengjiang Tan, Keti Zeka, Brian J Huntly, Sudhakaran Prabakaran, and Cristina Pina
- Subjects
acute myeloid leukaemia ,transcriptional heterogeneity ,epigenetics ,Kat2a ,Single-cell RNA seq ,transcriptional bursting ,Medicine ,Science ,Biology (General) ,QH301-705.5 - Abstract
Acute Myeloid Leukemia (AML) is an aggressive hematological malignancy with abnormal progenitor self-renewal and defective white blood cell differentiation. Its pathogenesis comprises subversion of transcriptional regulation, through mutation and by hijacking normal chromatin regulation. Kat2a is a histone acetyltransferase central to promoter activity, that we recently associated with stability of pluripotency networks, and identified as a genetic vulnerability in AML. Through combined chromatin profiling and single-cell transcriptomics of a conditional knockout mouse, we demonstrate that Kat2a contributes to leukemia propagation through preservation of leukemia stem-like cells. Kat2a loss impacts transcription factor binding and reduces transcriptional burst frequency in a subset of gene promoters, generating enhanced variability of transcript levels. Destabilization of target programs shifts leukemia cell fate out of self-renewal into differentiation. We propose that control of transcriptional variability is central to leukemia stem-like cell propagation, and establish a paradigm exploitable in different tumors and distinct stages of cancer evolution.
- Published
- 2020
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35. Training Load, Maturity Timing and Future National Team Selection in National Youth Basketball Players
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Jorge Arede, Tomás T. Freitas, David Johnson, John F. T. Fernandes, Sean Williams, Jason Moran, and Nuno Leite
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talent ,puberty ,growth ,maturation ,adolescence ,rate of perceived exertion ,Diseases of the musculoskeletal system ,RC925-935 - Abstract
Despite its importance to the management of training stress, monotony and recovery from exercise, training load has not been quantified during periods of intensity training in youths. This study aimed to (1) examine and quantify the training load (TL) in youth national team basketball players during a 2-week training camp according to maturity timing and (2) determine which parameters were related to under-18 (U18) national team selection. Twenty-nine U-16 national team basketball players underwent an anthropometric assessment to determine maturity timing. Players were categorised by maturity timing (early vs. average), whilst TL parameters during a 2-week training camp (i.e., 21 sessions) prior to FIBA U16 European Championship were used for group comparison and to predict future U-18 national team selection. The early-maturing players, who were taller and heavier (p < 0.05), experienced greater training strain in week 1 (p < 0.05) only. Irrespective of maturity timing, training loads in week 2 were predictive of onward selection for the U-18 national team. Conclusion: Based on present findings, practitioners are encouraged to develop their athletes’ ability to tolerate high weekly loads, but also to be mindful that athletes’ perceived exertion during national team training may be influenced by maturity timing.
- Published
- 2022
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36. Combating Vaccine Hesitancy: Teaching the Next Generation to Navigate Through the Post Truth Era
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Margarida Arede, Maria Bravo-Araya, Émilie Bouchard, Gurlal Singh Gill, Valerie Plajer, Adiba Shehraj, and Yassir Adam Shuaib
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immunization ,vaccine hesitancy ,critical thinking ,health education ,children ,Public aspects of medicine ,RA1-1270 - Abstract
Despite scientific evidence supporting the fact that vaccines are fundamental tools for preventing infectious diseases, a percentage of the population still refuses some or all of them. Vaccine hesitancy has become a widespread issue, and its complexity lies in the great variety of factors that can influence decisions about immunization, which are not just vaccine-related concerns, but also involve personal and societal levels. Our research group performed an extensive literature review to analyze: (1) different age groups, their relation to the problem and their characteristics; (2) the most important information (key messages) about immunization that could be used to counteract hesitancy; and (3) best approaches to transmit the messages to the target groups. We propose a long-term approach to overcome vaccine hesitancy that involves the education of children and adolescents on the basics about immunization and critical thinking, using different communication channels.
- Published
- 2019
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37. Estudios Luso-Hispanos de Historia del Derecho. Tomo II.
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da Silva, Cristina Nogueira, Seixas, Margarida, Álvarez-Gómez, Daniel, Eyang, José Luis Bibang Ondo, Gil, María Teresa Bouzada, Brízido, Anabela Paula, Coelho, Marcos Dias, Costa, Pietro, Majano, Francisco Javier Díaz, Ezquerra, Ignacio, Fouto, Ana Caldeira, Fernández, Víctor Gautier, Graes, Isabel, Jimeno-Borrero, Jesús, Blázquez, Francisco Miguel Martín, de Arede Nunes, Filipe, Nunes, João Andrade, Gallego-Burín, Marina Rojo, Santos, Jorge Silva, Simões, Sandro Alex Souza, Sastre, María Julia Solla, Testos, Jorge Veiga, do Nascimento Thomaz, Fernanda, Tito, Maíra, da Silva, Cristina Nogueira, Seixas, Margarida, Álvarez-Gómez, Daniel, Eyang, José Luis Bibang Ondo, Gil, María Teresa Bouzada, Brízido, Anabela Paula, Coelho, Marcos Dias, Costa, Pietro, Majano, Francisco Javier Díaz, Ezquerra, Ignacio, Fouto, Ana Caldeira, Fernández, Víctor Gautier, Graes, Isabel, Jimeno-Borrero, Jesús, Blázquez, Francisco Miguel Martín, de Arede Nunes, Filipe, Nunes, João Andrade, Gallego-Burín, Marina Rojo, Santos, Jorge Silva, Simões, Sandro Alex Souza, Sastre, María Julia Solla, Testos, Jorge Veiga, do Nascimento Thomaz, Fernanda, and Tito, Maíra
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- 2021
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38. The Official Knowledge and Adult Education Agents: An Ethnographic Study of the Adult Education Team of a Local Development-Oriented Nongovernmental Organization in the North of Portugal
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Loureiro, Armando Paulo Ferreira and Cristovao, Artur Fernando Arede Correia
- Abstract
Nongovernmental organizations, particularly those related to development work (local development-oriented nongovernmental organizations; LDNGO), and their agents have been assuming, in Portugal, an important role in the field of adult education. These organizations develop with the State, at the national level, and with supranational institutions and programs different types of relationships and arrangements, as a result of the activity in such educational arena. This article intends to question, on the basis of an ethnographic study of an adult education team of an LDNGO and using the pedagogical discourse model of Bernstein, the relationship that these agents establish with the official knowledge (pedagogical discourse) emerging from State-dependent intervention bodies. The results of the study shows that, even in strongly prescriptive working contexts, it is possible to develop an active relationship with the official knowledge and make recontextualizing uses of it.
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- 2010
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39. Are martial arts and combat sports a school for life? Relationships between sport attitudes and quality of life (intermediate results)
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Bruno Avelar-Rosa, António M. M. Quaresma, and Jorge Arede
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Martial arts ,combat sports ,ethics ,values ,youth development ,Sports ,GV557-1198.995 - Published
- 2016
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40. Neoplasias mamárias em canídeos
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Maria Madalena Lemos, Fernando Esteves, Rita Cruz Paiva, Carla Arede Santos, and Helena Vala
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Special aspects of education ,LC8-6691 ,Public aspects of medicine ,RA1-1270 - Abstract
As neoplasias em pequenos animais têm grande relevância na clínica de animais de companhia, não só pela sua incidência crescente, como pela sua gravidade. O presente trabalho pretende ser uma revisão sobre o tema, associado a informações obtidas do Laboratório de Anatomia Patológica da Escola Superior Agrária de Viseu. As neoplasias mamárias têm maior incidência nas fêmeas, não esterilizadas, geriátricas, sendo raras em animais com menos de 7 anos. A maioria dos autores concorda que quase todas estas neoplasias são malignas. Alguns sinais de malignidade são o tamanho do tumor, superior a 3cm, aderência aos tecidos, ulceração e envolvimento dos gânglios linfáticos. Estas neoplasias podem disseminar-se pelo organismo, processo designado metastização. Os locais mais frequentes são os gânglios linfáticos, os pulmões e o fígado. A cirurgia é o tratamento de eleição, excepto para neoplasias que apresentem metastização. Está descrita a realização da esterilização como preventiva e complemento do tratamento das neoplasias mamárias. A bibliografia consultada permitiu coligir dados relevantes e que procuram explicar a génese das neoplasias mamárias, nomeadamente no que diz respeito às influências hormonais, ao diagnóstico, a sua classificação e prognóstico clínico. São apresentadas imagens de vários tipos de tumores mamários em cadelas.
- Published
- 2016
41. Kinetic and Kinematic Assessment of the Band-Assisted Countermovement Jump
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Fernandes, John F.T., Arede, Jorge, Clarke, Hannah, Garcia-Ramos, Amador, Perez-Castilla, Alejandro, Norris, Jonty P., Wilkins, Celeste A., and Dingley, Amelia F.
- Abstract
Fernandes, JFT, Arede, J, Clarke, H, Garcia-Ramos, A, Perez-Castilla, A, Norris, JP, Wilkins, CA, and Dingley, AF. Kinetic and kinematic assessment of the band-assisted countermovement jump. J Strength Cond Res37(8): 1588–1593, 2023—This study sought to elucidate kinetic and kinematic differences between unloaded and band-assisted countermovement jumps (CMJs). In a randomized order, 20 healthy subjects (mass 84.5 ± 18.6 kg) completed 3 repetitions of CMJs across 3 conditions: unloaded (at body mass), low, and moderate band (8.4 ± 1.9 and 13.3 ± 3.3 kg body mass reduction, respectively). For all repetitions, a force platform and linear position transducer were used to record and calculate kinetic and kinematic data. Body mass was significantly different between the unloaded, low, and moderate band conditions (p< 0.05). Peak velocity, absolute peak, and mean force and movement duration displayed a trend that was mostly related to the condition (i.e., unloaded > low > moderate) (p< 0.05). The opposing trend (i.e., moderate > low > unloaded) was generally observed for relative peak and mean force, reactive strength index modified, and flight time (p< 0.05). No differences were observed for mean velocity, movement duration, and absolute and relative landing forces (p> 0.05). The use of band assistance during CMJs can alter force, time, and velocity variables. Practitioners should be aware of the potential positive and negative effects of band assistance during CMJs.
- Published
- 2023
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42. A experiência da Medicina de Família e Comunidade enquanto disciplina no curso de graduação em medicina
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Debora Carvalho Ferreira, Leticia Arede Almeida, Danillo Zeferino de Oliveira Souza, and João Vitor Peixoto Leal Zanirati
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Medicina de Família e Comunidade ,Atenção Primária à Saúde ,Educação Superior ,Educação de Graduação em Medicina ,Currículo ,Medicine (General) ,R5-920 ,Public aspects of medicine ,RA1-1270 - Abstract
Este estudo relata a experiência de implantação da disciplina eletiva de Medicina de Família e Comunidade (MFC) no curso de graduação em medicina, na visão dos discentes da Universidade Federal de Juiz de Fora, Minas Gerais, Brasil. Levando-se em conta a metodologia aplicada, verificou-se que os alunos consideraram os conteúdos práticos mais relevantes em comparação aos teóricos, o que pode ser atribuído ao fato de a prática permitir a crítica, a problematização e a resolução de situações cotidianas, sendo, além disso, um elo entre o jovem estudante de medicina e a realidade da prática médica. Diante da necessidade de aprimorar a abordagem integral à saúde dos indivíduos, considerando seus aspectos biopsicossociais, torna-se necessário que as alterações no currículo médico tenham como eixo norteador os princípios da Atenção Primária à Saúde (APS). Nesse contexto, a Medicina de Família e Comunidade (MFC) é a especialidade chave para a APS, pois estimula a formação de médicos generalistas capacitados a oferecerem cuidado longitudinal e responderem às necessidades em saúde das pessoas.
- Published
- 2014
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43. BIOMECÂNICA E ECONOMIA DE CORRIDA: ESTUDO DA LIGAÇÃO EM ALUNOS UNIVERSITÁRIOS
- Author
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Jorge Arede, Rogério Santos, and Hugo Sarmento
- Subjects
técnica e economia de corrida ,atletas ,Geography. Anthropology. Recreation ,Recreation. Leisure ,GV1-1860 ,Sports ,GV557-1198.995 - Abstract
A economia de corrida em atletas treinados encontra-se associada a uma menor percentagem da frequência cardíaca máxima (Pate, Macera, Bailey, Bartoli, & Powell, 1992).Esta tem uma grande importância para a performance dos atletas (Di Michele, 2008) e pode ser afetada por alterações na técnica de corrida (Tartaruga et al., 2012), nomeadamente por aspetos biomecânicos (Kyröläinen, Belli, & Komi, 2001).OBJETIVOVerificar a existência de relação entre variáveis cinemáticas da fase de contacto da corrida com variáveis psico-fisiológicas ligadas à economia de corrida, em alunos universitários.Conclusões: O ângulo do joelho no toe-off apresentou-se como um indicador de performance associado à técnica e economia de corrida, de tal forma que a extensão do joelho no toe-off pode ser entendido com um indicador de fadiga em exercícios realizados em intensidade submáxima.
- Published
- 2015
44. TACTICAL ANALYSIS OF ELITE FOOTBALL TEAMS – A MIXED METHOD APROACH
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Hugo Sarmento, Antonino Pereira, Jorge Campaniço, Jorge Arede, and José Leitão
- Subjects
Football ,counterattack ,analysis ,Geography. Anthropology. Recreation ,Recreation. Leisure ,GV1-1860 ,Sports ,GV557-1198.995 - Abstract
Soccer is a game with a random intermittent nature, whereby critical elements of the game are sometimes determined by chance. Research on match analysis in this sport has been mainly focused on the description of physical, physiological and technical game actions as an attempt to quantify the activity of players. Less work has been carried out on the match activities of soccer players, particularly the quantification of fundamental movement patterns of players during offensive sequences of play (for review see Sarmento et al. (2014)). Objectives: This study aimed to detect and analyse regular patterns of play in the counterattack of football teams, through the combination of the sequential analysis technique and interviews to first League Portuguese coaches.
- Published
- 2015
45. Modified whole-mount in situ hybridization protocol for the detection of transgene expression in electroporated chick embryos.
- Author
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Natacha Arede and Ana T Tavares
- Subjects
Medicine ,Science - Abstract
BACKGROUND: In vivo electroporation has been extensively used as an effective means of DNA transfer for analyzing gene function as well as gene regulation in developmental systems. In any of these two types of studies, the correct spatial and temporal expression of the electroporated transgene can only be accurately assessed by in situ hybridization. METHODOLOGY/PRINCIPAL FINDINGS: While analyzing transgene expression in electroporated chicken embryos, we verified that transgene riboprobes cross-hybridized with the exogenous plasmid DNA when embryos were processed by conventional whole-mount in situ hybridization (WISH). CONCLUSIONS/SIGNIFICANCE: Here we describe a modification to the WISH protocol that is essential to prevent DNA cross-hybridization and to specifically detect transgene mRNA transcripts in electroporated embryos. Our optimized WISH procedure can be applied not only to electroporated chick embryos but also to other embryos or adult tissues that have been transfected with large amounts of reporter- or expression construct DNA.
- Published
- 2008
- Full Text
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46. Performance indicators and functional adaptive windows in competitive cyclists: effect of one-year strength and conditioning training programme.
- Author
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Cesanelli, Leonardo, Ammar, Achraf, Arede, Jorge, Calleja-González, Julio, and Leite, Nuno
- Abstract
Changes and relationships between cycling performance indicators following a one-year strength and conditioning training have not been totally clarified. The aims of this study are to investigate (i) the effect of a combined one-year strength and conditioning training programme on performance indicators and the possible relationships between these indicators, and (ii) the existence of possible endurance-functional-adaptive windows (EFAWs) linked to changes in muscular strength and body composition markers. Functional and lactate threshold power (FTP and LTP), maximal strength (1RM) and body composition (body mass index [BMI], body cell mass [BCM] and phase angle [PA]) were measured at the beginning and the end of a one-year strength and conditioning training programme of thirty cyclists. Correlations, differences, and predictive analysis were performed among parameters. Significant differences were found between pre- and post-conditioning programme results for FTP, LTP, 1RM ( p < 0.0001) and BCM ( p = 0.038). When expressed as power output (W), FTP and LTP were significantly correlated with 1RM (r = 0.36, p = 0.005 and r = 0.37, p = 0.004, respectively), body mass (r = 0.30 and p = 0.02), BCM (r = 0.68, p < 0.001) and PA (r = 0.42 and 0.39, respectively and p < 0.001). When expressed as W⋅kg
_1 , these power thresholds were strongly correlated with body mass (r = -0.56 and -0.61, respectively) and BMI (r = -0.57 and -0.61 respectively) with p < 0.001. Predictive polynomial regressions revealed possible endurance and strength adaptation zones. The present findings indicated beneficial impacts of one-year strength and conditioning training on cycling performance indicators, confirmed the correlation between performance indicators, and suggested the existence of different EFAWs. Strategies aiming to improve performance should consider cyclist characteristics and performance goals to achieve EFAWs and thereby enhance cycling performance. [ABSTRACT FROM AUTHOR]- Published
- 2022
- Full Text
- View/download PDF
47. Estudios Luso-Hispanos de Historia del Derecho
- Author
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Varela, Laura Beck, Sastre, María Julia Solla, Brigas, Miriam Afonso, de Oliveira, Luís Cabral, Caleira, João Pedro, Caroni, Pio, Tagle, Fernando Liendo, Herraiz, Pedro Luis López, Reina, Antonio Luque, de Freitas Macedo, Camilla, González, Alfredo José Martínez, de Arede Nunes, Filipe, Pastoriza, Iván, Gallego-Burín, Martínez Marina Rojo, de Santa María Gómez-Mampaso, Blanca Sáenz, Seixas, Margarida, Daura, Josep Serrano, Testos, Jorge Veiga, del Mar Tizón Ferrer, María, Camallonga, Carlos Tormo, Varela, Laura Beck, Sastre, María Julia Solla, Brigas, Miriam Afonso, de Oliveira, Luís Cabral, Caleira, João Pedro, Caroni, Pio, Tagle, Fernando Liendo, Herraiz, Pedro Luis López, Reina, Antonio Luque, de Freitas Macedo, Camilla, González, Alfredo José Martínez, de Arede Nunes, Filipe, Pastoriza, Iván, Gallego-Burín, Martínez Marina Rojo, de Santa María Gómez-Mampaso, Blanca Sáenz, Seixas, Margarida, Daura, Josep Serrano, Testos, Jorge Veiga, del Mar Tizón Ferrer, María, and Camallonga, Carlos Tormo
- Published
- 2018
- Full Text
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48. Enhancing High-Intensity Actions During a Basketball Game After a Strength Training Program With Random Recovery Times Between Sets
- Author
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Arede, Jorge, Leite, Nuno, Tous-Fajardo, Julio, Bishop, Chris, and Gonzalo-Skok, Oliver
- Abstract
Arede, J, Leite, N, Tous-Fajardo, J, Bishop, C, and Gonzalo-Skok, O. Enhancing high-intensity actions during a basketball game after a strength training program with random recovery times between sets. J Strength Cond Res36(7): 1989–1997, 2022—To examine the effects of a strength training program with random recovery times between sets in consideration of several physical parameters, high-intensity actions, and spatial exploration index during a simulated basketball game. Twenty male basketball players (age: 19.45 ± 4.36 years) were assigned randomly to either strength training group (n= 10) or control group (n= 10). The strength training included parallel back squat and bench press exercises, twice a week for the duration of 10 weeks, with 2 blocks of 5 sets × 5 repetitions interspersed with variable passive recovery (range = 15–35 seconds) between sets, and constant passive recovery (3 minutes) between blocks with the load that maximized propulsive power output. The pre- and posttest assessments included jumping (bilateral and unilateral), change of direction, straight sprinting, and a 5-on-5 full-court situation. The external training load was assessed using the local positioning system, and the internal load was recorded with the use of individual heart rate monitors. A significant interaction effect (group × time) was observed on countermovement jump, unilateral right hops, high-intensity accelerations and decelerations, and peak accelerations and decelerations in the 5-on-5 full-court situation. Relative improvements observed and recorded in the training group on unilateral right hops, accelerations, and decelerations were correlated. Similar results were observed on 0- to 25-m sprints, high-intensity decelerations, peak accelerations, and decelerations. Strength training paired with random recovery times enhanced physical and game-related aspects in the observed basketball players.
- Published
- 2022
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49. Overstrength of RC Medium Length Span Bridges
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Ibarra, Alma R. Sánchez, Arede, Antonio J., Guerrero, José M. Jara, and Delgado, Pedro
- Abstract
Overstrength factors in bridges reported in various studies show great diversity that depends on the type of bridges selected and the set of seismic records used in the analyses. Particularly in Mexico, there are no previous studies that evaluate the bridges’ overstrength. This study determines overstrength factors in medium-length reinforced concrete bridges based on dynamic nonlinear analyses to establish design parameters in bridge regulations in Mexico. More than 3000 nonlinear time history analyses were carried out using 48 bridge models subjected to seismic records from an interplate seismic source. Based on the results, the overstrength factors of simply supported bridges with spans of 30 m and 50 m and substructures composed of one or more reinforced concrete columns were determined.
- Published
- 2022
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50. KAT2A complexes ATAC and SAGA play unique roles in cell maintenance and identity in hematopoiesis and leukemia
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Arede, Liliana, Foerner, Elena, Wind, Selinde, Kulkarni, Rashmi, Domingues, Ana Filipa, Giotopoulos, George, Kleinwaechter, Svenja, Mollenhauer-Starkl, Maximilian, Davison, Holly, Chandru, Aditya, Asby, Ryan, Samarista, Ralph, Gupta, Shikha, Forte, Dorian, Curti, Antonio, Scheer, Elisabeth, Huntly, Brian J.P., Tora, Laszlo, and Pina, Cristina
- Abstract
Epigenetic histone modifiers are key regulators of cell fate decisions in normal and malignant hematopoiesis. Their enzymatic activities are of particular significance as putative therapeutic targets in leukemia. In contrast, less is known about the contextual role in which those enzymatic activities are exercised and specifically how different macromolecular complexes configure the same enzymatic activity with distinct molecular and cellular consequences. We focus on KAT2A, a lysine acetyltransferase responsible for histone H3 lysine 9 acetylation, which we recently identified as a dependence in acute myeloid leukemia stem cells and that participates in 2 distinct macromolecular complexes: Ada two-A-containing (ATAC) and Spt-Ada-Gcn5-Acetyltransferase (SAGA). Through analysis of human cord blood hematopoietic stem cells and progenitors, and of myeloid leukemia cells, we identify unique respective contributions of the ATAC complex to regulation of biosynthetic activity in undifferentiated self-renewing cells and of the SAGA complex to stabilization or correct progression of cell type–specific programs with putative preservation of cell identity. Cell type and stage-specific dependencies on ATAC and SAGA-regulated programs explain multilevel KAT2A requirements in leukemia and in erythroid lineage specification and development. Importantly, they set a paradigm against which lineage specification and identity can be explored across developmental stem cell systems.
- Published
- 2022
- Full Text
- View/download PDF
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