Author: "Ardic S" - Searchworks@Jio Institute Digital Library Search Results

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78 results on '"Ardic S"'

1. X-ray quiz: A 72-year-old female with acute tachypnoea

Author: Akoglu, H, Coban, E, Ardic, S, and Diktas, S
Published: 2012

2. Poster abstracts

Author: Ferrie, J., Shipley, M., Cappuccio, F., Brunner, E., Miller, M., Kumari, M., Marmot, M., Coenen, A., Castillo, J. L., Araya, F., Bustamante, G., Montecino, L., Torres, C., Oporto, S., Gronli, J., Fiske, E., Murison, R., Bjorvatn, B., Sorensen, E., Ursin, R., Portas, C. M., Rajaraman, S., Gribok, A., Wesensten, N., Balkin, T., Reifman, J., Dursunoglu, N., Ozkurt, S., Baser, S., Delen, O., Sarikaya, S., Sadler, P., Mitchell, P., Françon, D., Decobert, M., Herve, B., Richard, A., Griebel, G., Avenet, P., Scatton, B., Fur, G. L., Eckert, D., Jordan, A., Wellman, A., Smith, S., Malhotra, A., White, D., Bruck, D., Thomas, I., Kritikos, A., Oertel, W., Stiasny-Kolster, K., Garcia-Borreguero, D., Poewe, W., Hoegl, B., Kohnen, R., Schollmayer, E., Keffel, J., Trenkwalder, C., Valle, A., Roizenblatt, S., Fregni, F., Boggio, P., Tufik, S., Ward, K., Robertson, L., Palmer, L., Eastwood, P., Hillman, D., Lee, J., Mukherjee, S., de Padova, V., Barbato, G., Ficca, G., Zilli, I., Salzarulo, P., Veldi, M., Hion, T., Vasar, V., Kull, M., Nowak, L., Davis, J., Latzer, Y., Tzischinsky, O., Crowley, S., Carskadon, M., Anca-Herschkovitsch, M., Frey, D., Ortega, J., Wiseman, C., Farley, C., Wright, K., Campbell, A., Neill, A., Spiegel, K., Leproult, R., Tasali, E., Scherberg, N., van Cauter, E., Noradina, A. T., Karim, N. A., Norlinah, I., Raymond, A. A., Sahathevan, R., Hamidon, B., Werth, E., Poryazova, R., Khatami, R., Bassetti, C., Beran, R. G., Ainley, L., Holand, G., Duncan, J., Kinney, H., Davis, B., Hood, B., Frey, S., Schmidt, C., Hofstetter, M., Peigneux, P., Cajochen, C., Hu, W.-P., Li, J.-D., Zhang, C., Boehmer, L., Siegel, J., Zhou, Q.-Y., Sagawa, Y., Kondo, H., Takemura, T., Kanayama, H., Kaneko, Y., Sato, M., Kanbayashi, T., Hishikawa, Y., Shimizu, T., Viola, A., James, L., Schlangen, L., Dijk, D.-J., Andretic, R., Kim, Y.-C., Han, K.-A., Jones, F., Greenspan, R., Sanford, L., Yang, L., Tang, X., Dieter, K., Uta, E., Sven, H., Richard, M., Oyane, N., Pallesen, S., Holsten, F., Inoue, Y., Fujita, M., Emura, N., Kuroda, K., Uchimura, N., Johnston, A., Astbury, J., Kennedy, G., Hoedlmoser, K., Schabus, M., Pecherstorfer, T., Moser, S., Gruber, G., Anderer, P., Klimesch, W., Naidoo, N., Ferber, M., Pack, A., Neu, D., Mairesse, O., Hoffmann, G., Dris, A., Lambrecht, L., Linkowski, P., Verbanck, P., Le Bon, O., Matsuura, N., Yamao, M., Adachi, N., Aritomi, R., Komada, Y., Tanaka, H., Shirakawa, S., Kondoh, H., Takemura, F., Ohnuma, S., Suzuki, M., Uemura, S., Iskra-Golec, I., Smith, L., Thanh, D.-V., Boly, M., Phillips, C., Steven, L., Luxen, A., Maquet, M., Jay, S., Dawson, D., Lamond, N., Basner, M., Fomberstein, K., Dinges, D., Ogawa, K., Nittono, H., Yamazaki, K., Hori, T., Glamann, C., Hornung, O., Hansen, M.-L, Danker-Hopfe, H., Jung, C., Kecklund, G., Anund, A., Peters, B., Åkerstedt, T., Verster, J., Roehrs, T., Mets, M., de Senerpont Domis, L., Olivier, B., Volkerts, E., Knutson, K., Lauderdale, D., Rathouz, P., Christie, M., Chen, L., Bolortuya, Y., Lee, E., Mckenna, J., Mccarley, R., Strecker, R., Tamaki, M., Matsuoka, T., Aritake, S., Suzuki, H., Kuriyama, K., Ozaki, A., Abe, Y., Enomoto, M., Tagaya, H., Mishima, K., Matsuura, M., Uchiyama, M., Lima-Pacheco, E., Davis, K., Sabourin, C., Lortie-Lussier, M., de Koninck, J., van Der Werf, Y., van Der Helm, E., Schoonheim, M., van Someren, E., Tokley, M., Ball, M., Sato, T., Ghilardi, M. F., Moisello, C., Bove, M., Busi, M., Pelosin, E., Tononi, G., Eguchi, N., Sakata, M., Urade, Y., Doe, N., Yoshihara, K., Abe, K., Manabe, Y., Iwatsuki, K., Hayashi, T., Shoji, M., Kamiya, T., Gooley, J., Brainard, G., Rajaratnam, S., Kronauer, R., Czeisler, C., Lockley, S., Phillips, A., Robinson, P., Burgess, H., Revell, V., Eastman, C., Bihari, S., Ramakrishnan, N., Camerino, D., Conway, P. M., Costa, G., Vandewalle, G., Albouy, G., Sterpenich, V., Darsaud, A., Rauchs, G., Berken, P.-Y, Balteau, E., Maquet, P., Tendero, J. A., Domenech, M. P., Isern, F. S., Martínez, C., Roure, N., Sancho, E. E., Moreno, C. R., Silva, M., Marqueze, E. C., Waage, S., Bobko, N., Chernyuk, V., Yavorskiy, Y., Saxvig, I., Sørensen, E., de Mello, M. T., Esteves, A., Teixeira, C., Bittencourt, L. R., Silva, R., Pires, M. L., Mottram, V., Middelton, B., Arendt, J., Amaral, O., Rodrigues, M., Pereira, C., Tavares, I., Baba, K., Honma, S., Honma, K.-I., Yamanaka, Y., Hashimoto, S., Tanahashi, Y., Nishide, S.-Y, Honma, K.-I, Sletten, T., Middleton, B., Lederle, K., Skene, D., Roth, T., Walsh, J., Hogben, A., Ellis, J., Archer, S., von Schantz, M., Chen, N.-H., Wang, P.-C., Chen, C.-W., Lin, Y., Shih, T.-S., Armstrong, S., Redman, J., Stephan, E., David, M., Delanaud, S., Chardon, K., Libert, J.-P., Bach, V., Telliez, F., Reid, K., Jaksa, A., Eisengart, J., Kane, P., Naylor, E., Zee, P., Viola, A. U., de Valck, E., Hofmans, J., Theuns, P., Cluydts, R., Alexander, G., Karel, M., Christina, R., Sohn, I.-K., Cho, I. H., Kim, S. J., Yu, S.-H., Kim, H., Yoo, S. Y., Koh, S.-H., Cho, S.-J., Rotenberg, L., Silva-Costa, A., Griep, R. H., Amely, T., Kennedy, G. A., Pavlis, A., Thompson, B., Pierce, R., Howard, M., Briellmann, R., Venkateswaran, S., Blunden, S., Krawczyk, E., Blake, J., Gururajan, R., Kerr, D., Matuisi, T., Iwasaki, M., Yamasita, N., Iemura, A., Ohya, T., Yanagawa, T., Misa, R., Coleman, G., Conduit, R., Duce, B., Hukins, C., Nyandaiti, Y. W., Bamaki, S., Mohammed, A., Kwajarfa, S., Veeramachaneni, S. P., Murthy, A., Wilson, A., Maul, J., Hall, G., Stick, S., Moseley, L., Gradisar, M., Kurihara, T., Yamamoto, M., Yamamoto, S., Kuranari, M., Sparks, C. B., Bartle, A., Beckert, L., Latham-Smith, F. B., Hilton, J., Whitehead, B., Gulliver, T., Salvini, A., Grahame, S., Swift, M., Laybutt, N., Sharon, D., Mack, C., Hymell, B., Perrine, B., Ideshita, K., Taira, M., Matuo, A., Furutani, M., van Dongen, H., Mott, C., Huang, J.-K., Mollicone, D. J., Mckenzie, F., Dinges, David, Barnes, M., Rochford, P., Churchward, T., O’Donoghue, F., Penzel, T., Fietze, I., Canisius, S., Bekiaris, E., Terrill, P. 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Y. S., Cassaglia, P., Yu, V. Y. H., Walker, A. M., Kohler, M., Kennedy, D., Martin, J., van Den Heuvel, C., Lushington, K., Herron, K., Khurana, C., Sterr, A., Olivadoti, M., Toth, L., Opp, M., Dang-Vu, T., Degueldre, C., Gais, S., Dang-Vu, T. T., Desseilles, M., Philips, C., Chijavadze, E., Babilodze, M., Chkhartishvili, E., Nachkebia, N., Mchedlidze, O., Dzadzamia, S., Griffiths, R., Walker, A., Horovitz, S., Fukunaga, M., Carr, W., Picchioni, D., de Zwart, J., van Gelderen, P., Braun, A., Duyn, J., Hanlon, E. H., Faraguna, U., Vyazovskiy, V., Cirelli, C., Ocampo-Garcés, A., Ibáñez, F., López, S., Vivaldi, E., Torrealba, F., Romanowski, C. P. 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W., Basheer, R., Aizawa, R., Sunahara, H., Abe, S.-I., Iwaki, S., Houjyou, M., Satoh, M., Suda, H., Kheirandish-Gozal, L., Gozal, D., Walker, P., Noa, A., O’Driscoll, D., Ng, M., Yang, J., Davey, M., Anderson, V., Trinder, J., Horne, R., Sands, S., Kelly, V., Sia, K., Edwards, B., Skuza, E., Davidson, M., Berger, P. H. I. L. I. P., Wilkinson, M., Sánchez-Narváez, F., Gutiérrez, R., Camacho, L., Anaya, E., García-Campos, E., Labra, A., Domínguez, G., García-Polo, L., Haro, R., Verginis, N., Nixon, G., Baumert, M., Pamula, Y., Mihai, R., Wawurszak, M., Smith, N., Yiallourou, S., Andrew Ramsden, C., Williamson, B., Blecher, G., Teng, A., Dakin, C. Y. N., Yuil, M., Harris, M., Sadasivam, S., Bennison, J., Galland, B., Dawes, P., Taylor, B., Norman, M., Edwards, N., Harrison, H., Kol, C., Sullivan, C., Valladares, E., Macey, P., Kumar, R., Woo, M., Harper, R., Alger, J., Mcnamara, D., Tang, J., Goh, A., Teoh, O. H., Chiang, W. C., Chay, O. M., Marie Salvini, A., Riben, C., Blanck, A.-S., Marklund, M., Tourneux, P., Cardot, V., Leke, A., Iqbal, S. M., (Gus) Cooper, D., Witmans, M., Rodger, K., Thevasagayam, R., El-Hakim, H., Hill, C. M., Baya, A., Bucks, R., Kirkham, F., Virues-Ortega, J., Baldeweg, T., Paul, A., Hogan, A., Goodwin, J., Silva, G., Kaemingk, K., Sherrill, D., Morgan, W., Fregosi, R., Quan, S., Evans, C., Maclean, J., Waters, K., Fitzsimmons, D., Hayward, P., Fitzgerald, D., Terrill, G., O’Connell, A., Vannan, K., Richardson, H., Poluektov, M., Levin, I., Snegodskaya, M., Kolosova, N., Geppe, N., Nixon, G. 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D., Xu, X.-H., Makino, Y., Hashimoto, K., Zhang, M., Sastre, J.-P., Buda, C., Anaclet, C., Ohtsu, H., Danober, L., Desos, P., Cordi, A., Roger, A., Jacquet, A., Rogez, N., Thomas, J.-Y., Krentner, M., Boutin, J., Audinot-Bouchez, V., Baumann, C., Valko, P., Uhl, M., Hersberger, M., Rupp, T., Uchiyama, N., Nakamura, N., Konishi, T., Mcgrath, P., Fujiki, N., Tokunaga, J., Iijima, S., Nishino, S., Catherine, B.-R., Lely, F., Ralf, K., Oliver, N., François, J., Francois, J., Cedric, F., Changbin, Q., Patrick, H., Homanics, G., Heussler, H., Norris, R., Pache, D., Charles, B., Mcguire, T., Shelton, J., Bonaventure, P., Kelly, L., Aluisio, L., Lovenberg, T., Atack, J., Dugovic, C., Shapiro, C., Shen, J., Trajanovic, N., Chien, J., Verma, M., Fish, V., Wheatley, J., Amis, T., Alexiou, T., Wild, J., Bjursell, A., Solin, P., Sato, S., Matsubuchi, N., Gingras, M.-A., Labrosse, M., Chevrier, É, Lageix, P., Guay, M.-C., Braun, C., Godbout, R., Fatim, E. H., Loic, D., Stephane, D., Nathalie, L., Stéphane, D., Alain, G., Wiâm, R., Koabyashi, T., Tomita, S., Ishikawa, T., Manadai, O., Arakawa, K., Siato, Y., Bassi, A., Ocampo, A., Estrada, J., Blyton, D., O’Keeffe, K., Galletly, D., Larsen, P., Amatoury, J., Bilston, L., Kairaitis, K., Stephenson, R., Chu, K., Sekiguchi, Y., Suzuki, N., Yasuda, Y., Kodama, T., Honda, Y., Hsieh, K.-C., Lai, Y.-Y., Bannai, M., Kawai, N., Amici, R., Baracchi, F., Cerri, M., Del Sindaco, E., Dentico, D., Jones, C. A., Luppi, M., Martelli, D., Perez, E., Tazaki, M., Katayose, Y., Yasuda, K., Tokuyama, K., Maddison, K., Platt, P., Kirkness, J., Ware, J. C., May, J., Rosenthal, T., Park, G., Guibert, M., Allen, R. W., Cetin, T., Roman, V., Mollicone, D., Crummy, F., Cameron, P., Swann, P., Kossman, T., Taggart, F., Kandala, N.-B., Currie, A., Peile, E., Stranges, S., Marshall, N., Peltonen, M., Stenlof, K., Hedner, J., Sjostrom, L., Anderson, C., Platten, C., Jordan, K., Horne, J., Bjorkum, A., Kluge, B., Braseth, T., Gurvin, I., Kristensen, T., Nybo, R., Rosendahl, K., Nygaard, I., Biggs, S., Dollman, J., Kennedy, J. D., Martin, A. J., Haghighi, K. S., Bakht, N., Hyde, M., Harris, E., Zerouali, Y., Hosein, A., Jemel, B., Dodd, M., Rogers, N., Andersen, M., Martins, R., Alvarenga, T., Antunes, I., Papale, L., Killgore, W. S., Axelsson, J., Lekander, M., Ingre, M., Brismar, K., Dorrian, J., Ferguson, S., Jones, C., Buxton, O., Marcelli, E., Phipps-Nelson, J. O., Teixeira, L. R., de Castro Moreno, C., Turte, S. L., Nagai, R., do Rosário Dias De Oliveira Latorre, M., Marina, F., Paterson, J., Jackson, M., Johnston, P., Papafotiou, K., Croft, R., Dawson, S., Leenaars, C., Sandberg, H., Joosten, R., Dematteis, M., Feenstra, M., Wehrle, R., Rieger, M., Widmann, A., Dietl, T., Philipp, S., Wetter, T., Drummond, S., Czisch, M., Cairns, A., Lebourgeois, M., Harsh, J., Baulk, S., Vakulin, A., Catcheside, P., Antic, N., Mcevoy, D., Orff, H., Salamat, J., Meloy, M. 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T., Collins, A., Jerums, G., Hare, D., Panagiotopoulos, S., Weatherhead, B., Bailey, M., Neil, C., Goldsworthy, U., Hill, C., Valencia-Flores, M., Resendiz, M., Juarez, S., Castano, A., Santiago, V., Aguilar, C., Ostrosky, F., Krum, H., Kaye, D., Neves, C., Decio, M., Monteiro, M., Cintra, F., Poyares, D., Viegas, C., Silva, C., Oliveira, H., Peixoto, T., Mikami, A., Watanabe, T., Kumano-Go, T., Adachi, H., Sugita, Y., Takeda, M., Oktay, B., Firat, H., Akbal, E., Ardic, S., Paim, S., Santos, R., Barrreto, A., Whitmore, H., Imperial, J., Temple, K., Rue, A., Hoffman, L., Liljenquist, D., Kazsa, K., Pavasovic, M., Copland, J., Ho, M., Jayamaha, J., Peverill, R., Hii, S., Hensley, M., Rowland, S., Windler, S., Johansson, M., Eriksson, P., Peker, Y., Råstam, L., Lindblad, U., Grote, L., Zou, D., Radlinski, J., Eder, D., Plens, C. M., Garcia Gonzaga, F. M., Farias Sa, P., Franco Oliveira, L. V., Faria Sa, P., Yoon, I.-Y., Chung, S., Hee Lee, C., Kim, J.-W., Faludi, B., Wang, X., Li, Q., Wan, H., Li, M., Pallayova, M., Donic, V., Tomori, Z., Ioacara, S., Olech, T., Mccallum, C., Bowes, M., Bowes, J., Chia, M., Gilbert, S. S., Sajkov, D., Teichtahl, H., Stevenson, I., Cunnington, D., Kalman, J., Szaboova, E., Higami, S., Kryger, M., Higami, Y., Suzuki, C., Kitano, H., Carin, S., Olof, S., Yngve, G., Gösta, B., Carlberg, B., Stenlund, H., Franklin, K. A., Oliveira, A., Vasconcelos, L., Martinez, D., Goncalves, S. C., Gus, M., Silva, E. O. A., Fuchs, S. C., Fuchs, F. 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M., Elprince, M., Ismail, N., Elserogi, W., Yeo, A., George, K., Thomson, K., Stadler, D., Bradley, J., Paul, D., Schwartz, A., Hagander, L., Harlid, R., Hultcrantz, E., Haraldsson, P., Cho, J.-G., Narayan, J., Nagarajah, M., Perri, R., Johnson, P., Burgess, K., Chau, N., Mcevoy, R. D., Arnardottir, E. S., Thorleifsdottir, B., Olafsson, I., Gislason, T., Tsuiki, S., Fujimatsu, S., Munezawa, T., Sato, Y., Subedi, P., Ainslie, P., Topor, Z., Whitelaw, W., Chan, M., So, H., Lam, H., Ng, S., Chan, I., Lam, C., Saigusa, H., Higurashi, N., He, Z. M., Cui, X. C., Li, J., Dong, X., Lv, Y., Zhou, M., Han, X., An, P., Wang, L., Macey, P. M., Serber, S., Cross, R., Yan-Go, F., Marshall, M., Rees, D., Lee, S. H., Ho Cho, J. I., Shin, C., Lee, J. Y., Kwon, S. Y., Kim, T.-H., Vedam, H., Barnes, D., Walter, H., Karin, J., Hermann, P., Belyavskiy, E., Galitsyn, P., Arbolishvili, G., Litvin, A., Chazova, I., Mareev, V., Ramar, K., Khan, A., Gay, P., Strömberg, A., Ulander, M., Fridlund, B., Mårtensson, J., Yee, B., Desai, A., Buchanan, P., Crompton, R., Melehan, K., Wong, P., Tee, A., Ng, A., Darendeliler, M. A., Ye, L., Maislin, G., Hurley, S., Mccluskey, S., Weaver, T., Yun, C.-H., Ji, K.-H., Ahn, J. Y., Lee, H.-W., Zhang, X., Yin, K., Zhaofang, G., Chong, L., Navailles, B., Zenou, E., Cheze, L., Pignat, J.-C., Tang, T., Remmers, J., Vasilakos, K., Denotti, A., Gilholme, J., Castronovo, V., Marelli, S., Aloia, M., Fantini, M. 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R., Munro, J., Zimmerman, M., Stanchina, M., Millman, R., Cassel, W., Ploch, T., Loh, A., Koehler, U., Jerrentrup, A., Greulich, T., Doyle, G., Pascoe, T., Jorgensen, G., Baglioni, C., Lombardo, C., Espie, C., Violani, C., Edell-Gustafsson, U., Swahn, E., Ejdeback, J., Tygesen, H., Johansson, A., Neckelmann, D., Hilde Nordhus, I., Zs-Kovács, Á., Vámos, E., Zs-Molnár, M., Maisuradze, L., Gugushvili, J., Darchia, N., Gvilia, I., Lortkipanidze, N., Oniani, N., Wang-Weigand, S., Mayer, G., Roth-Schechter, B., Hsu, S.-C., Yang, C.-M., Liu, C.-Y., Ito, H., Omvik, S., Nordhus, I. H., Farber, R., Scharf, M., Harris-Collazo, R., Pereira, J., Andras, S., Ohayon, M., David, B., Morgan, K., Voorn, T., Vis, J., Kuijer, J., Fortier-Brochu, E., Beaulieu-Bonneau, S., Ivers, H., Morin, C., Beaulieu-Benneau, S., Harris, J., Bartlett, D., Paisley, L., Moncada, S., Toelle, B., Bonnet, M. H., Arand, D., Bonnet, J., Bonnet, M., Doi, Y., Edéll-Gustafsson, U., Strijers, R., Fernando, A., Arroll, B., Warman, G., Funakura, M., Shikano, S., Unemoto, Y., Fujisawa, M., Hong, S.-C., Jeong, J.-H., Shin, Y.-K., Han, J.-H., Lee, S.-P., Lee, J.-H., Mignot, E., Nakajima, T., Hayashida, K., Honda, M., Ardestani, P., Etemadifar, M., Nejadnik, H., Maghzi, A. H., Basiri, K., Ebrahimi, A., Davoodi, M., Peraita-Adrados, R., Vicario, J. L., Shin, H.-B., Marti, I., Carriero, L., Fulda, S., Beitinger, P., Pollmacher, T., Lam, J. S. P., Fong, S. Y. Y., Tang, N. L. S., Ho, C. K. W., Li, A. M. C., Wing, Y. K., Guilleminault, C., Black, J., Wells, C., Kantor, S., Janisiewicz, A., Scammell, T., Tanaka, S., Smith, A., Neufing, P., Gordon, T., Fuller, P., Gompf, H., Pedersen, N., Saper, C., Lu, J., Sasai, T., Donjacour, C., Fronczek, R., Le Cessie, S., Lammers, G. J., van Dijk, J. G., Hayashi-Ogawa, Y., Okuda, M., Lam, V. K.-H., Chen, A. L., Ho, C. K.-W., Wing, Y.-K., Lehrhaft, B., Brilliante, R., van Der Zande, W., Overeem, S., van Dijk, G., Lammers, J. G., Opazo, C. J., Jeong, D.-U., Sung, Y. H., Lyoo, I. K., Takahashi, Y., Murasaki, M., Bloch, K., Jung, H., Dahab, M. M., Campos, T. F., Mccabe, S., Maravic, K., Wiggs, L., Connelly, V., Barnes, J., Saito, Y., Ogawa, M., Murata, M., Nadig, U., Rahman, A., Aritake, K., D’Cruz, O., Suzuki, K., Kaji, Y., Takekawa, H., Nomura, T., Yasui, K., Nakashima, K., Bahammam, A., Rab, M. G., Owais, S., Alsuwat, K., Hamam, K., Zs, M., Boroojerdi, B., Giladi, N., Wood, D., Sherman, D., Chaudhuri, R., Partinen, M., Abdo, F., Bloem, B., Kremer, B., Verbeek, M., Cronlein, T., Mueller, U., Hajak, G., Zulley, J., Namba, K., Li, L., Mtsuura, M., Kaneita, Y., Ohida, T., Cappeliez, B., Moutrier, R., De, S., Dwivedi, S., Chambers, D., Gabbay, E., Watanabe, A., Valle, C., Kauati, A., Watanabe, R., Chediek, F., Botte, S., Azevedo, E., Kempf, J., Cizza, G., Torvik, S., Brancati, G., Smirne, N., Bruni, A., Goff, E., Freilich, S., Malaweera, A., Simonds, A., Mathias, C., Morrell, M., Rinsky, B., Fonarow, G., Gradinger, F. P., Boldt, C., Geyh, S., Stucki, A., Dahlberg, A., Michel, F., Savard, M.-H., Savard, J., Quesnel, C., Hirose, K., Takahara, M., Mizuno, K., Sadachi, H., Nagashima, Y., Yada, Y., Cheung, C.-F., Lau, C., Lai, W., Sin, K., Tam, C., Hellgren, J., Omenaas, E., Gíslason, T., Jögi, R., Franklin, K., Torén, K., Wang, F., Kadono, M., Shigeta, M., Nakazawa, A., Ueda, M., Fukui, M., Hasegawa, G., Yoshikawa, T., de Niet, G., Tiemens, B., Lendemeijer, B., Hutschemaekers, G., Gauthier, A.-K., Chevrette, T., Chevrier, E., Bouvier, H., Parry, B., Meliska, C., Nowakowski, S., Lopez, A., Martinez, F., Sorenson, D., Lien, M. L., Lattova, Z., Maurovich-Horvat, E., Nia, S., Pollmächer, T., Poulin, J., Chouinard, S., Stip, E., Guillem, F., Venne, D., Caouette, M., Lamont, M.-E., Lázár, A., Lázár, Z., Bíró, A., Gyõri, M., Tárnok, Z., Prekop, C., Gádoros, J., Halász, P., Bódizs, R., Okun, M., Hanusa, B., Hall, M., Wisner, K., Pereira, M., Kumar, R. A. J. E. S. H., Macey, P. A. U. L., Woo, M. A. R. Y., Serber, S. T. A. C. Y., Valladares, E. D. W. I. N., Harper, R. E. B. E. C. C. A., Harper, R. O. N. A. L. D., Puttonen, S., Härmä, M., Vahtera, J., Kivimäki, M., Lamarche, L., Hemmeter, U. M., Thum, A., Rocamora, R., Giesler, M., Haag, A., Dodel, R., Krieg, J. C., Shechter, A., L’Esperance, P., Boivin, D. B., Vu, M.-T., and Richards, H.
Published: 2007
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3. Frequency and importance of metabolic syndrome in obstructive sleep apnea syndrome: P131

Author: OKTAY, B., AKBAL, E., FIRAT, H., and ARDIC, S.
Published: 2006

4. Correlation between head and neck physical examination of obstructive sleep apnea syndrome and habitual snorers: P001

Author: FIRAT, H., KURUKAHCEVIOGLU, S., and ARDIC, S.
Published: 2006

5. Serum Levels of Myeloperoxidase and Its Relationship with 3-Nitrotyrosine in Lung Cancer

Author: Yardim-Akaydin, S., Caliskan-Can, E., Ece Miser Salihoğlu, Inseloz, E., Firat, H., and Ardic, S.
Published: 2017

6. Prevalence of sleep disorders in the Turkish adult population epidemiology of sleep study

Author: Demir A.U., Ardic S., Firat H., Karadeniz D., Aksu M., Ucar Z.Z., Sevim S., Ozgen F., Yilmaz H., Itil O., Peker Y., Aygul F., Kiran S., Gelbal S., Cepni Z., Akozer M., Neyal A., Cilli A., Ozsancak A., Kutlu A., Salepci B., Baklan B., Oktay B., Tuncel D., Levent E., Ekinci E., Eyuboglu F., Yildiz F., Kirbas G., Kaynak H., Aydin H., Boyaci H., Bora I., Oztura I., Aslan K., Gunhan K., Habesoglu M.A., Unlu M., Demet M., Dursunoglu N., Tascilar N., Yavuz N., Erdinc O., Araz O., Dogan O.T., Yetkin O., Celik P., Alp R., Altin R., Bilgin S., Ismailogullari S., Gazioglu S., Ozkurt S., Velioglu S., Yetkin S., Kuyucu T., Atay T., Uygunoglu U., Tutar U., Celik Y., Bulbul Y., Demir, A.U., Department of Chest Diseases, Hacettepe University, Ankara, Turkey -- Ardic, S., Department of Occupational Health and Medicine, Institute of Public Health, Hacettepe University, Ankara, Turkey -- Firat, H., Department of Educational Sciences, Hacettepe University, Ankara, Turkey -- Karadeniz, D., Department of Chest Diseases, Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey -- Aksu, M., Sleep Disorders Diagnosis and Treatment Center, Ministry of Health Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkey -- Ucar, Z.Z., Department of Psychiatry, Gulhane Military Academy of Medicine, Ankara, Turkey -- Sevim, S., Epidemiology Unit, Refik Saydam National Public Health Agency, Ankara, Turkey -- Ozgen, F., Ankara, Turkey -- Yilmaz, H., Department of Neurology, Cerrahpasa University, Istanbul, Turkey -- Itil, O., Department of Neurology, Erciyes University, Kayseri, Turkey -- Peker, Y., Department of Pulmonary Diseases, Dr Suat Seren Chest Diseases and Surgery Training and Research Hospital, Izmir, Turkey -- Aygul, F., Department of Chest Diseases, Dokuz Eylül University, Izmir, Turkey -- Kiran, S., Department of Neurology, Mersin University, Mersin, Turkey -- Gelbal, S., Department of Neurology, Celal Bayar University, Manisa, Turkey -- Cepni, Z., Department of Neurology, Celal Bayar University, Manisa, Turkey -- Akozer, M., Department of Emergency and Cardiovascular Medicine, Sahlgrenska Academy, University of Gothenburg and Sleep Medicine Unit, Skaraborg Hospital, Skövde, Sweden -- Neyal, A., Gaziantep Cengiz Gokcek State Hospital, Gaziantep, Turkey -- Cilli, A., Department of Chest Diseases, Akdeniz University, Antalya, Turkey -- Ozsancak, A., Department of Chest Diseases, Baskent University, Adana, Turkey -- Kutlu, A., Department of Neurology, Kocaeli University, Kocaeli, Turkey -- Salepci, B., Department of Chest Diseases, Ministry of Health KartalTraining and Research Hospital Sleep Center, Istanbul, Turkey -- Baklan, B., Department of Neurology, 9 Eylul University Faculty of Medicine, Hospital, Izmir, Turkey -- Oktay, B., Mardin State Hospital, Mardin, Turkey -- Tuncel, D., Department of Neurology, Kahramanmaras University, Kahramanmaras, Turkey -- Levent, E., Department of Chest Diseases, Maltepe University, Istanbul, Turkey -- Ekinci, E., Department of Chest Diseases, Gaziantep University, Gaziantep, Turkey -- Eyuboglu, F., Department of Chest Diseases, Baskent University, Adana, Turkey -- Yildiz, F., Department of Neurology, Kocaeli University, Kocaeli, Turkey -- Kirbas, G., Department of Chest Diseases, Dicle University, Diyarbakir, Turkey -- Kaynak, H., Department of Neurology, Cerrahpasa Faculty of Medicine, Istanbul, Turkey -- Aydin, H. -- Boyaci, H., Department of Neurology, Uludag University, Bursa, Turkey -- Bora, I., Department of Neurology, Cukurova University, Adana, Turkey -- Oztura, I., Department of Neurology, 9 Eylul University Faculty of Medicine, Hospital, Izmir, Turkey -- Aslan, K., Department of Otorhinolaryngology, Celal Bayar University, Manisa, Turkey -- Gunhan, K., Department of Chest Diseases, Afyon Kocatepe University, Afyon, Turkey -- Habesoglu, M.A., Department of Psychiatry, Celal Bayar University, Manisa, Turkey -- Unlu, M., Department of Psychiatry, Gulhane Military Medical Academy, Ankara, Turkey -- Demet, M., Department of Chest Diseases, Pamukkale University, Denizli, Turkey -- Dursunoglu, N., Department of Neurology, Bulent Ecevit University, Zonguldak, Turkey -- Tascilar, N., Corlu, Tekirdag, Turkey -- Yavuz, N., Department of Neurology, Osmangazi University, Eskisehir, Turkey -- Erdinc, O., Department of Chest Diseases, Rize State Hospital, Rize, Turkey -- Araz, O., Department of Chest Diseases, Cumhuriyet University, Sivas, Turkey -- Dogan, O.T., Department of Chest Diseases, Inonu University, Malatya, Turkey -- Yetkin, O., Department of Chest Diseases, Celal Bayar University, Manisa, Turkey -- Celik, P., Department of Neurology, Kafkas University, Kars, Turkey -- Alp, R., Samsun Chest Diseases Hospital, Samsun, Turkey -- Altin, R., Department of Neurology, Karadeniz Technical University, Trabzon, Turkey -- Bilgin, S., Department of Neurology, Erciyes University, Kayseri, Turkey -- Ismailogullari, S., Department of Psychiatry, Gulhane Military Medical Academy, Ankara, Turkey -- Gazioglu, S., Department of Neurology, Bulent Ecevit University, Zonguldak, Turkey -- Ozkurt, S., Department of Neurology, Bulent Ecevit University, Zonguldak, Turkey -- Velioglu, S., Department of Psychiatry, Gulhane Military Medical Academy, Ankara, Turkey -- Yetkin, S., Ministry of Health Sureyya Pasa Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul, Turkey -- Kuyucu, T., Ministry of Health Bakirkoy Prof., Mazhar Osman Bakirkoy, Psychiatry Training and Research Hospital, Istanbul, Turkey -- Atay, T., Suruc State Hospital, Suruc, Sanliurfa, Turkey -- Uygunoglu, U., Department of Neurology, Trakya University, Edirne, Turkey -- Tutar, U., Samsun Chest Diseases Hospital, Samsun, Turkey -- Celik, Y., Department of Neurology, Trakya University, Edirne, Turkey -- Bulbul, Y., Department of Psychiatry, Gulhane Military Medical Academy, Ankara, Turkey, and Maltepe Üniversitesi
Subjects: Aging, age distribution, insomnia, sex difference, prevalence, Article, sleep disordered breathing, male, mental disorders, controlled study, human, sleep disorder, adult, questionnaire, daytime somnolence, Sleep disorders, Epworth sleepiness scale, major clinical study, Turkish citizen, aged, female, priority journal, risk factor, restless legs syndrome, Epidemiology and public health, snoring
Abstract: Blackwell Publishing, Sleep disorders constitute an important public health problem. Prevalence of sleep disorders in Turkish adult population was investigated in a nationwide representative sample of 5021 Turkish adults (2598 women and 2423 men, response rate: 91%) by an interviewer-administered questionnaire. Insomnia was defined by the DSM-IV criteria, habitual snoring and risk for sleep-related breathing disorders (SDB) by the Berlin questionnaire, excessive daytime sleepiness (EDS) by the Epworth sleepiness scale score, and restless legs syndrome (RLS) by the complaints according to the International Restless Legs Syndrome Study Group criteria. Mean age of the participants was 40.7 ± 15.1 (range 18 to 90) years. Prevalence rates (men/women) were insomnia 15.3% (10.5%/20.2%; P < 0.001), high probability of SDB 13.7% (11.1%/20.2%; P < 0.001), EDS 5.4% (5.0%/5.7%; P: 0.09), RLS 5.2% (3.0%/7.3%; P < 0.001). Aging and female gender were associated with higher prevalence of sleep disorders except for habitual snoring. Prevalence rates of the sleep disorders among Turkish adults based on the widely used questionnaires were close to the lower end of the previous estimates reported from different parts of the world. These findings would help for the assessment of the health burden of sleep disorders and addressing the risk groups for planning and implementation of health care. Sleep and Biological Rhythms © 2015 Japanese Society of Sleep Research., Demir, A.U.; Department of Chest Diseases, Hacettepe UniversityTurkey
Published: 2015

7. RISK OF OBSTRUCTIVE SLEEP APNEA IN THE TURKISH ADULT POPULATION

Author: Itil, O., Aksu, M., Sevim, S., Yilmaz, H., Oktay, B., Firat, H., Ucar, Z., Demir, A., Ardic, S., and Karadeniz, D.
Published: 2012

8. Evaluation of Mid-Regional Pro-Adrenomedullin, Mid-Regional Pro-atrial Natriuretic Peptide, and Procalcitonin for the Diagnosis and Risk Stratification of Emergency Department Patients With Dyspnea

Author: Acar, A., Cevik, E., Yokusoglu, M., Bilgi, C., Comert, B., Ardic, S., Cinar, O., Madsen, T., and Kaya, C.
Published: 2011

9. Association between circadian rhythm, sleep disturbances and temperament in major depression, bipolar disorder and schizophrenia

Author: Tunç, S., Yağcı, İ., Yenilmez Bilgin, Y., Canbek, Ö., Atagün, M.İ., Hüseyinoğlu, N., and Ardıç, S.
Published: 2016
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10. Analysis of traumatic mortality cases

Author: Ardic, S., primary, Arziman, I., additional, Kaldirim, U., additional, Tuncer, S.K., additional, Durusu, M., additional, Eyi, Y.E., additional, Erkencigil, M., additional, and Yasar, S.M., additional
Published: 2013
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11. Formation of a parenchymal pseudocyst following a blunt thoracic trauma

Author: Tuncer, A.K., primary, Kaldirim, U., additional, Ardic, S., additional, Eyi, Y.E., additional, Durusu, M., additional, and Yasar, S.M., additional
Published: 2013
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12. A different trauma, a different fracture

Author: Kaldırım, Ü., primary, Eyi, Y.E., additional, Aydin, A., additional, Tuncer, S.K., additional, Ardic, S., additional, Durusu, M., additional, and Yasar, S.M., additional
Published: 2013
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13. Impact of continuous positive airway pressure therapy on left atrial function in patients with obstructive sleep apnea

Author: Vural, M. G., primary, Bilgin, E., additional, Firat, H., additional, Akdemir, R., additional, Ardic, S., additional, and Yeter, E., additional
Published: 2013
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14. 2 Evaluation of Mid-Regional Pro-Adrenomedullin, Mid-Regional Pro-atrial Natriuretic Peptide, and Procalcitonin for the Diagnosis and Risk Stratification of Emergency Department Patients With Dyspnea

Author: Cinar, O., primary, Cevik, E., additional, Acar, A., additional, Kaya, C., additional, Ardic, S., additional, Comert, B., additional, Yokusoglu, M., additional, Bilgi, C., additional, and Madsen, T., additional
Published: 2011
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15. (P2-62) An Infrequent Case of Orthopedic Emergencies – Open Dorsal Dislocation of the Proximal Interphalangeal (PIP) Joint Dislocation

Author: Bayir, A., primary, Kaldirim, U., additional, Ardic, S., additional, Eyi, Y.E., additional, Arziman, I., additional, and Durusu, M., additional
Published: 2011
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16. Evaluation of Non-Invasive Parameters in Pulmonary Embolism.

Author: Saygideger, Y, primary, Sever, O, additional, Oktay, B, additional, Sevgi, E, additional, and Ardic, S, additional
Published: 2009
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17. Diagnostic Value of Leptin in Pleural Effusions.

Author: Duru, S, primary, Sonmez, Z, additional, Saygideger, Y, additional, Dikmen, G, additional, Sever, O, additional, and Ardic, S, additional
Published: 2009
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18. O0039 Evaluation of the relationship between H-FABP levels and the risk of cardiac damage in patients with obstructive sleep apnea syndrome

Author: Oktay, B., primary, Akbal, E., additional, Firat, H., additional, Ardic, S., additional, and Akdemir, R., additional
Published: 2007
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19. A rare intrahepatic portacaval tubular shunt in a patient with spastic paraparesis

Author: Ardic, S, primary, Deniz, E, additional, Arbatli, M, additional, Ardic, FA, additional, and Aysun, A, additional
Published: 1997
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20. PP-293 SEVERE BRADYCARDIA DUE TO MAD-HONEY INTOXICATION IN TWO PATIENTS

Author: Kaldırım, U., Balta, S., Ardıc, S., Demirkol, S., Tavlaşoglu, M., Unlu, M., Arslan, Z., and Küçük, U.
Published: 2013
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21. Evaluation of mid-regional pro-atrial natriuretic peptide, procalcitonin, and mid-regional pro-adrenomedullin for the diagnosis and risk stratification of dyspneic ED patients.

Author: Cinar O, Cevik E, Acar A, Kaya C, Ardic S, Comert B, Yokusoglu M, Bilgi C, Meisner M, Madsen T, Cinar, Orhan, Cevik, Erdem, Acar, Ayhan, Kaya, Cengiz, Ardic, Sukru, Comert, Bilgin, Yokusoglu, Mehmet, Bilgi, Cumhur, Meisner, Michael, and Madsen, Troy
Abstract: Objective: The aim of this study was to evaluate the diagnostic and the prognostic value of a laboratory panel consisting of mid-regional pro-atrial natriuretic peptide (MR-proANP), procalcitonin (PCT), and mid-regional pro-adrenomedullin (MR-proADM) for patients presenting to the emergency department (ED) with acute dyspnea.Methods: We prospectively enrolled ED patients who presented with a chief complaint of dyspnea and who had an uncertain diagnosis after physician evaluation. Final primary diagnosis of the cause of shortness of breath was confirmed through additional testing per physician discretion. We recorded inpatient admission and 30-day mortality rates.Results: One hundred fifty-four patients were enrolled in the study. Congestive heart failure exacerbation was the final primary diagnosis in 42.2% of patients, while infectious etiology was diagnosed in 33.1% of patients. For the diagnosis of congestive heart failure exacerbation, MR-proANP had a sensitivity of 92.7% and specificity of 36.8%, with a negative likelihood ratio (LR-) of 0.16 and a positive likelihood ratio (LR+) of 1.44 (cut-off value: 120 pmol/L). For the diagnosis of an infectious etiology, PCT had a 96.5% specificity and 48.8% sensitivity (LR-: 0.58, LR+: 13.8, cutoff value: 0.25 ng/mL). As a prognostic indicator, MR-proADM demonstrated similar values: odds ratio for 30-day mortality was 8.5 (95% CI, 2.5-28.5, cutoff value: 1.5 nmol/L) and the area under the receiver operating characteristic curve in predicting mortality was 0.81 (95% CI, 0.71-0.91).Conclusion: The good negative LR- of MR-proANP and the good positive LR+ of PCT may suggest a role for these markers in the early diagnosis of ED patients with dyspnea. Furthermore, MR-proADM may assist in risk stratification and prognosis in these patients.. [ABSTRACT FROM AUTHOR]
Published: 2012
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22. Oxidative status, nitric oxide metabolites, and asymmetric dimethylarginine levels in obstructive sleep apnea syndrome

Author: Ozkan, Y., Hikmet FIRAT, Simsek, B., Ardic, S., and Yardim-Akaydin, S.

23. No Suspicion, No Disease! Renal Infarction: Case Series

Author: Karacabey, S., Hocagil, ., Erkman SANRI, Hocagil, A. C., Ardic, S., and Suman, E.

24. The effectiveness of oropharyngeal exercises compared to inspiratory muscle training in obstructive sleep apnea: A randomized controlled trial.

Author: Erturk N, Calik-Kutukcu E, Arikan H, Savci S, Inal-Ince D, Caliskan H, Saglam M, Vardar-Yagli N, Firat H, Celik A, Yuce-Ege M, and Ardic S
Subjects: Continuous Positive Airway Pressure, Exercise, Exercise Therapy, Humans, Sleep, Sleep Apnea, Obstructive therapy
Abstract: Background: Inspiratory muscle training (IMT) and oropharyngeal exercises (OE) have different advantages and disadvantages and a comparison of these modalities has been recommended. The aim of this study was to compare the effects of IMT and OE on important outcomes for patients with OSAS., Methods: This was a randomized controlled clinical trial. Forty-one clinically stable OSAS patients not receiving CPAP therapy were randomly divided into three groups. Patients in the IMT group (n = 15) trained with a threshold loading device 7 days/week for 12 weeks. Patients in the OE group (n = 14) practiced exercises 5 days/week for 12 weeks. Twelve patients served as control group. Apnea-hypopnea index (AHI), respiratory muscle strength, snoring severity and frequency (Berlin Questionnaire), daytime sleepiness (Epworth Sleepiness Scale; ESS), sleep quality (Pittsburg Sleep Quality Index; PSQI), impact of sleepiness on daily life (Functional Outcomes of Sleep Questionnaire; FOSQ), and fatigue severity (Fatigue Severity Scale; FSS) were evaluated before and after the interventions., Results: AHI and sleep efficiency did not change significantly in any of the groups. Significant decreases in snoring severity and frequency, FSS and PSQI total scores were found in the IMT and OE groups after the treatments (p < 0.05). There was a significant reduction in neck and waist circumference and significant improvement in respiratory muscle strength (MIP and MEP) in IMT group compared to control group (p < 0.05). The%MEPpred value and FOSQ total score significantly increased and ESS score reduced after the treatment in OE group compared to control group (p < 0.05)., Conclusions: Our results indicate that both OE and IMT rehabilitation interventions are applicable in rehabilitation programs for OSAS patients who do not accept CPAP therapy. Our findings could lead to increase these methods' use among rehabilitation professionals and decrease in cost of CPAP treatment in OSAS., Competing Interests: Declaration of Competing Interest The authors have no conflict of interests to declare., (Copyright © 2020 Elsevier Inc. All rights reserved.)
Published: 2020
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25. Extending the Phenotypic Spectrum of Huntington Disease: Hypothermia.

Author: Altıner Ş, Ardic S, and Çebi AH
Abstract: Huntington disease (HD) is an autosomal dominant progressive neurodegenerative disorder associated with expanded CAG repeat size in the huntingtin gene and usually presenting with movement disorder, psychiatric symptoms, and cognitive decline. Sleep problems, weight loss, and cachexia are also common. Here, we report a patient presenting with hypothermia in late-stage HD. Although thermoregulatory defects were documented in animal models, this is the first report describing HD with hypothermia in humans., Competing Interests: The authors have no conflicts of interest to declare., (Copyright © 2020 by S. Karger AG, Basel.)
Published: 2020
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26. Comparison of the diagnostic values of vascular adhesion protein-1 and intestinal fatty acid-binding protein in the diagnosis of acute mesenteric ischemia.

Author: Sahin A, Altay DA, Demir S, Yulug E, Menteşe A, Tatli O, Karaca Y, Ardic S, Gunduz A, and Turedi S
Subjects: Acute Disease, Animals, Female, Ileum blood supply, Ileum pathology, Mesenteric Ischemia diagnosis, Mesenteric Ischemia pathology, Random Allocation, Rats, Rats, Sprague-Dawley, Amine Oxidase (Copper-Containing) blood, Cell Adhesion Molecules blood, Fatty Acid-Binding Proteins blood, Mesenteric Ischemia blood
Abstract: Objectives: The aim of this study is to compare the diagnostic values of plasma levels of vascular adhesion protein-1 (VAP-1) and intestinal fatty acid-binding protein (I-FABP) for diagnosing acute mesenteric ischemia (AMI)., Methods: The study used a randomized, controlled experimental design. Forty-two female Sprague-Dawley rats were divided into three control groups and three ischemia groups. Plasma VAP-1 and I-FABP levels were measured, and the extent of ischemic damage was determined using a histopathological damage score in terminal ileum tissue samples., Results: In the early phase of AMI (i.e. at the 30-min time point), VAP-1 levels did not differ between the control and ischemia groups (p > 0.05), but I-FABP levels were significantly higher in the ischaemia groups (p = 0.017). Although both VAP-1 and I-FABP levels increased in the ischaemia groups, only VAP-1 levels showed a significant increase compared to the control group at the 2-h time point (p = 0.011). Ischemic damages associated with AMI became the most prominent at the 6-h time point. During this phase, both VAP-1 and I-FABP levels were significantly higher in the ischemia groups than in the control groups (p = 0.007 and p = 0.002, respectively). Both VAP-1 and I-FABP levels showed a significant correlation with ischemic changes, but a higher correlation was observed for VAP-1 levels (r = 0.771)., Conclusions: Both I-FABP and VAP-1 levels were useful for diagnosing AMI, but VAP-1 levels correlated better with the extent of ischaemic damage.
Published: 2019
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27. The value of endoplasmic reticulum stress markers (GRP78 and CHOP) in the diagnosis of acute mesenteric ischemia.

Author: Ardic S, Gumrukcu A, Gonenc Cekic O, Erdem M, Reis Kose GD, Demir S, Kose B, Yulug E, Mentese A, and Turedi S
Subjects: Animals, Biomarkers metabolism, Disease Models, Animal, Ileum pathology, Mesenteric Ischemia metabolism, Random Allocation, Rats, Rats, Sprague-Dawley, Reperfusion Injury, Endoplasmic Reticulum Stress, Heat-Shock Proteins metabolism, Mesenteric Ischemia diagnosis, Oxidative Stress, Transcription Factor CHOP metabolism
Abstract: Aim: To evaluate levels of the endoplasmic reticulum (ER) stress markers GRP78 and CHOP in acute mesenteric ischemia (AMI) and to examine relations with degrees of AMI-related intestinal injury., Materials and Methods: Twenty-four rats were divided into four groups. Group I and Group III represented the control groups, from which blood and tissue specimens were collected 2 and 6 h after laparotomy without superior mesenteric artery (SMA) ligation. Group II and Group IV constituted the ischemia groups, from which blood and tissue specimens were collected 2 and 6 h after SMA ligation. The ER stress markers GRP78 and CHOP, total oxidant status (TOS), total antioxidant status (TAS), and the oxidative stress index (OSI) were investigated in each group. Ileum specimens were assessed in terms of ischemic injury, and appropriate comparisons were performed., Results: Significantly higher GRP78, CHOP, TOS, and TAS values were determined in the ischemia groups (groups II and IV) compared to the control groups (groups I and III). This elevation was greater in the 6 h ischemia group, the group exposed to the greatest ischemic injury (Group IV). Significant and powerful correlation was present between histopathological damage and levels of the ER stress markers and oxidative markers., Conclusion: According to our results, ER stress markers (GRP78 and CHOP) increase significantly following ischemic injury. This elevation has the potential to be used diagnostically and also in prognostic terms due to the powerful correlation it exhibits with AMI-related ischemic injury., (Copyright © 2018 Elsevier Inc. All rights reserved.)
Published: 2019
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28. Endoplasmic reticulum stress markers are of no value in predicting cardiopulmonary resuscitation success and survival in out-of hospital cardiac arrest: A nested case-control study.

Author: Ardic S, Yilmaz S, Demir S, Dogramaci S, Altuntas G, Imamoglu M, Mentese A, and Turedi S
Abstract: Objectives: The purpose of this study was to determine the value of the endoplasmic reticulum (ER) stress markers glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP) and PERK in predicting the success of cardiopulmonary resuscitation (CPR) or post-CPR survival., Materials and Methods: Non-traumatic out-of-hospital CA patients were included in this prospective, nested case-control study. Standard CPR and post-resuscitative care were applied. Levels of ER stress markers were measured at presentation and were investigated to determine whether they might constitute a marker predicting return of spontaneous circulation (ROSC) or sustained ROSC, and of 24-h, and 1 and 3-month survival., Results: Fifty-two out of 99 non-traumatic CA patients were enrolled. ROSC was determined at a level of 25%, sustained ROSC at 23%, 24-h survival at 7%, and 1- and 3-month survival at 4.6%. No difference was determined in terms of ER stress markers between patients with and without ROSC or sustained ROSC. Only PERK levels were higher in surviving patients than non-surviving subjects in terms of 24-h survival (p = 0.01). Otherwise, no stress markers differed between surviving and non-surviving patients at any survival time point., Conclusion: ER stress markers are of no value in determining establishment of ROSC or sustained ROSC, success of CPR, or survival. Only PERK levels may be valuable in terms of 24-h survival.
Published: 2019
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29. Absenteeism and Delay to Work Due to Sleep Disorders in the Turkish Adult Population: A Questionnaire-Based National Survey.

Author: Firat H, Yuceege M, Kiran S, Akgun M, Demir AU, Aksu M, Ardic S, Karadeniz D, Ucar ZZ, Sevim S, Itil O, and Yilmaz H
Subjects: Adult, Female, Humans, Male, Middle Aged, Surveys and Questionnaires, Time Factors, Turkey epidemiology, Absenteeism, Sleep Wake Disorders epidemiology, Work statistics & numerical data
Abstract: Sleep problems may have negative effects on work-life balance, overall health, and safety. We aimed to investigate the association between sleep disorders and absenteeism and delay to work (being late or tardy) among the working adult population. The study was conducted by using data from a large survey of working adults who participated in the Turkish Adult Population Epidemiology of Sleep Study (TAPES) managed by Turkish Sleep Medicine Society (TSMS). Secondary analyses was employed to examine absenteeism and delay to work and their associations with sleep problems, including sleepiness by Epworth Sleepiness Scale (ESS), parasomnias, sleep apnea (by Berlin Questionnaire), sleep quality (by Pittsburgh Sleep Quality Index), and restless leg. History of any absenteeism and delay to work was observed in 276 (18%) and 443 (29%) out of 1,533 working adults, respectively. In the multivariate analyses, absenteeism was associated with younger age, female gender and poor sleep quality, while delay to work was associated with younger age, poor sleep quality, parasomnia, and sleepiness. In the presence of absenteeism and delay to work, sleep disorders including sleepiness, poor sleep quality, and parasomnia should be considered. Such evaluation may improve worker well-being and provide some additional benefits in terms of increasing productivity and lowering work-related costs.
Published: 2019
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30. Evaluation of sleep quality in patients with ankylosing spondylitis and efficacy of anti-TNF-α therapy on sleep problems: A polisomnographic study.

Author: Karatas G, Bal A, Yuceege M, Firat H, Gurcay E, Ardic S, and Cakci FA
Subjects: Adult, Antirheumatic Agents adverse effects, Biological Products adverse effects, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prospective Studies, Remission Induction, Severity of Illness Index, Sleep Wake Disorders etiology, Sleep Wake Disorders physiopathology, Spondylitis, Ankylosing complications, Spondylitis, Ankylosing diagnosis, Spondylitis, Ankylosing immunology, Surveys and Questionnaires, Time Factors, Treatment Outcome, Tumor Necrosis Factor-alpha immunology, Antirheumatic Agents therapeutic use, Biological Products therapeutic use, Polysomnography, Sleep, Sleep Wake Disorders diagnosis, Spondylitis, Ankylosing drug therapy, Tumor Necrosis Factor-alpha antagonists & inhibitors
Abstract: Introduction: This study was conducted to investigate the relationship between sleep quality (SQ) and disease activity (DA) in patients with ankylosing spondylitis (AS) and to evaluate the response to anti-tumor necrosis factor α (anti-TNF-α) therapy on sleep disorders., Materials and Methods: A total of 34 patients who met the modified New York classification criteria for AS were included in this prospective study. Patients were divided into two groups as follows: Group I (n = 15) with high DA and receiving anti-TNF-α therapy, and Group II (n = 19) in remission. DA was assessed by the Bath AS Disease Activity Index. Pittsburgh Sleep Quality Index (PSQI) and polysomnography (PSG) were used to determine disorders and patterns of sleep, respectively, in both groups at baseline as well as at the third month of anti-TNF-α therapy in Group I., Results: Baseline evaluation revealed impaired SQ in 57.9% of all patients. PSG demonstrated obstructive sleep apnea syndrome, snoring and periodic leg movements in 73.7%, 74.4% and 26.3% of patients, respectively. Prior to anti-TNF-α therapy, PSQI and snoring score were significantly higher in Group I (P = 0.0001, P = 0.012, respectively). Although there was a significant reduction in PSQI scores in Group I (P = 0.005) at the third month of anti-TNF-α therapy, no change was observed in PSG parameters (P > 0.05)., Conclusion: Sleep disorders increase in AS, particularly in patients with high DA. Anti-TNF-α therapy has improved SQ without any improvement in PSG. Therefore, it may be concluded that PSG parameters might be more associated with disease pathogenesis rather than DA in patients with AS., (© 2017 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons Australia, Ltd.)
Published: 2018
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31. Can water lacerate a tendon? A car-wash accident: A lacerated extensor hallucis longus tendon.

Author: Ardic S, Altun I, Peker G, and Kose B
Abstract: Our purpose in this report, involving an unusual mechanism described for the first time in the literature, is to show that high-pressure water sprays used for washing cars can cause injury to the extensor hallucis longus (EHL). A 21-year-old man presented to our emergency department (ED) due to looseness in the hallux. His history revealed that while operating a pressurized water spray machine for car-washing one week before, he had inadvertently sprayed his foot, and despite wearing protective plastic boots this had resulted in a laceration at the level of the hallux, which had been sutured in a state hospital. Cleaning equipment using pressurized water can be dangerous if sufficient safety measures are not taken. We think that such occupational accidents with serious outcomes can be prevented through simple protective measures.
Published: 2018
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32. Acute effects of the electromagnetic waves emitted by mobile phones on attention in emergency physicians.

Author: Altuntas G, Sadoglu D, Ardic S, Yilmaz H, Imamoglu M, and Turedi S
Subjects: Adult, Female, Humans, Male, Attention radiation effects, Cell Phone, Electromagnetic Radiation, Emergency Medicine, Physicians psychology
Abstract: Study Objective: The purpose of this study was to investigate the acute effects of the electromagnetic waves (EMW) emitted by mobile phones on attention in emergency physicians., Methods: This single-center, prospective, randomized, double-blinded clinical study was performed among emergency physicians in a tertiary hospital. Thirty emergency physicians were enrolled in the study. Initial d2 test was applied in the evaluation of attention and concentration of all the physicians, who were randomly assigned into one of two groups. The control group members hold mobile phones in 'off' mode to their left ears for 15min. The members of the intervention group hold mobile phones in 'on' mode to their left ears for 15min, thus exposing them to 900-1800MHz EMW. The d2 test was re-applied to both groups after this procedure. Differences in attention and concentration levels between the groups were compared., Results: Difference between initial and final d2 test in total performance (TN-E, p=0.319), in total number of figures marked (TN, p=0.177), in test performance percentile (PR, p=0.619) and in attention fluctuation (FR, p=0.083) were similar between the groups. However, difference in the number of figures missed (E1 selective attention, p=0.025), difference between numbers of incorrectly marked figures (E2, p=0,018) and difference in focus levels (E, p=0.016) were significantly in favor of the intervention group., Conclusion: According to our study findings, the EMW emitted by mobile phones has no deleterious effect on the attention and concentration levels of emergency physicians, and even has a positive impact on selective attention levels., (Copyright © 2017 Elsevier Inc. All rights reserved.)
Published: 2018
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33. Alteration of serum levels of inflammatory cytokines and polysomnographic indices after uvulopalatal flap surgery in obstructive sleep apnea.

Author: Mutlu M, Vuralkan E, Akin I, Firat H, Ardic S, Akaydin S, and Miser E
Subjects: Adult, C-Reactive Protein analysis, Cystatin C blood, Female, Humans, Intercellular Adhesion Molecule-1 blood, Male, Middle Aged, Polysomnography statistics & numerical data, Postoperative Period, Preoperative Period, Sleep Apnea, Obstructive physiopathology, Sleep Apnea, Obstructive surgery, Treatment Outcome, Tumor Necrosis Factor-alpha blood, Cytokines blood, Palate surgery, Severity of Illness Index, Sleep Apnea, Obstructive blood, Surgical Flaps, Uvula transplantation
Abstract: The aim of the current study was to compare the changes in polysomnographic indices and serum levels of C-reactive protein (CRP), cystatin C, tumor necrosis factor-α (TNF-α), and intercellular adhesion molecule-1 (ICAM-1) in patients with obstructive sleep apnea (OSA) who were treated surgically via a uvulopalatal flap (UPF) technique. Twenty-five patients (14 men, 11 women), average age 46.2 ± 9.3 years, who underwent UPF surgery were included in this study. Serum biochemical analyses and polysomnographic examinations were performed before and 6 months after the surgery. Pre- and postoperative values of apnea hypopnea index (AHI), oxygen desaturation index (ODI), and minimum oxygen concentrations, as well as serum levels of CRP, cystatin C, TNF-α, and ICAM-1 were compared. Comparison of variables before and after UPF surgery demonstrated that AHI (p = 0.001), ODI (p < 0.001) and oxygen saturation (p < 0.001) were significantly improved. In addition, serum levels of CRP (p = 0.036), cystatin C (p = 0.005), TNF-α (p < 0.001), and ICAM-1 (p < 0.001) were significantly reduced 6 months after surgery. Our results suggest that UPF is an effective surgical method that alleviates the severity of OSA. Moreover, it may have the potential to prevent the development of atherosclerosis by attenuating the inflammatory process induced by activation of inflammatory mediators such as CRP, TNF-α, ICAM-1, and cystatin C.
Published: 2017
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34. The evaluation of sleep quality and response to anti-tumor necrosis factor α therapy in rheumatoid arthritis patients.

Author: Karatas G, Bal A, Yuceege M, Yalcin E, Firat H, Dulgeroglu D, Karataş F, Sahin S, Cakci A, and Ardic S
Subjects: Adult, Aged, Antirheumatic Agents adverse effects, Arthritis, Rheumatoid complications, Female, Humans, Male, Middle Aged, Polysomnography, Prospective Studies, Quality of Life, Remission Induction, Severity of Illness Index, Treatment Outcome, Antirheumatic Agents therapeutic use, Arthritis, Rheumatoid drug therapy, Sleep, Sleep Wake Disorders complications, Tumor Necrosis Factor-alpha antagonists & inhibitors
Abstract: Poor sleep quality (SQ) is increasingly recognized as giving rise to decreased quality of life, and raising pain perception. Our aim is to evaluate the SQ in rheumatoid arthritis (RA) patients treated with anti-tumor necrosis factor alpha (anti-TNF-α) therapy. This was a prospective observational and open-label study of RA patients. A total of 35 patients with RA were enrolled in this study. Of the 35 patients, 22 had high disease activity (DA), and 13 were in remission. High DA group was initiated an anti TNF-α therapy. Clinical and objective parameters of SQ were assessed by using the Pittsburgh Sleep Quality Index (PSQI) and polysomnography (PSG). The total PSQI score and the frequency of poor SQ were high in 60 % of the RA patients. The median PSQI score was significantly higher in the high DA group than in the remission group (P = 0.026). Following an anti-TNF-α therapy initiation, significant improvements were observed in the high DA group by PSQI test (P = 0.012). However, no statistically significant difference was found by PSG (P > 0.05). Although an improvement in DA with anti-TNF-alpha therapy did not provide an amelioration in laboratory parameters, we found a significant improvement in SQ by subjective PSQI test. These findings may support that sleep disorders in RA are likely to be associated with a complex pathophysiology.
Published: 2017
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35. Serum Salusin Levels in ST-Segment Elevation Myocardial Infarction.

Author: Yilmaz M, Atescelik M, Ardic S, Goktekin MC, Yildiz M, Gurger M, Kobat MA, and Ilhan N
Subjects: Adult, Aged, Aged, 80 and over, Atherosclerosis, Biomarkers blood, Case-Control Studies, Female, Heart Rate physiology, Humans, Male, Middle Aged, ST Elevation Myocardial Infarction physiopathology, Intercellular Signaling Peptides and Proteins blood, ST Elevation Myocardial Infarction blood
Abstract: Background: In our study, we aimed to determine the change in levels of salusin-alpha and salusin-beta at admission and after the treatment in patients with STEMI, who have active atherosclerosis., Methods: Serum salusin-alpha and beta levels of 50 patients diagnosed with STEMI in the emergency department were measured at admission and on 7th day post-treatment and compared with serum salusin levels of 50 healthy volunteers., Results: In STEMI patients, salusin-alpha levels were found to be significantly decreased (p < 0.001) and salusinbeta levels were found to be significantly increased (p < 0.001) compared to healthy volunteers in the control group. 7th day post-treatment salusin-alpha levels were found to be lower and salusin-beta levels were found to be at a higher level compared to healthy individuals (p < 0.001). Negative correlation (r = -.322 p = 0.023) was found between salusin-alpha levels and pulse rate. But no significant correlation was found between salusin-beta levels and biochemical parameters., Conclusions: The data of this study support the fact that salusin-alpha levels decrease and salusin-beta levels increase in acute cases such as STEMI.
Published: 2016
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36. Hot-press hand injury caused by roller type ironing machine.

Author: Yapici AK, Kaldirim U, Arziman I, Ardic S, and Eroglu M
Abstract: Thermal crush burn injury due to roller type ironing press machine is relatively rare and can cause destructive effects with significant morbidity. These injuries can be avoided by taking some basic precautions. Early debridement after admission and definitive treatment after the extent of injury are delineated and these are the preferred approaches in the management. We present a case of thermal crush injury of the hand caused by laundry roller type ironing press machine.
Published: 2016
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37. Comparison of two main treatment modalities for acute ankle sprain.

Author: Bilgic S, Durusu M, Aliyev B, Akpancar S, Ersen O, Yasar SM, and Ardic S
Abstract: Objective: Acute ankle sprains are one of the most common injuries in emergency departments. Immobilization is widely accepted as the basic treatment modality for acute ankle sprains; however, immobilization method remains controversial. In this study, we aimed to compare two treatment modalities: splint and elastic bandage for the management of acute ankle sprains., Methods: This prospective study was conducted in the emergency department. Fifty-one consecutive patients who were admitted to the emergency department owing to the complaint of ankle sprain and who were treated with an elastic bandage or a splint were included in the study. After bone injury was ruled out, treatment choice was left to the on-shift physicians' discretion. The extent of edema was evaluated before and after the treatment by using a small, graduated container filled with warm water. Volume differences were calculated by immersing both lower extremities in a container filled to a constant level. Pain was evaluated using the visual analogue scale., Results: There were 25 patients in the elastic bandage group and 26 patients in the splint group. VAS scores of these groups before and after the treatment were similar. Although edema size before and after the treatment were similar between the groups, edema size reduction was significantly more in the elastic bandage group [p=0,025]., Conclusions: This study showed that treatment of acute ankle sprains with an elastic bandage was more effective than splint in reducing edema. Therefore, an elastic bandage could be preferred over a splint for the treatment of acute ankle sprains.
Published: 2015
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38. Prevalence of insomnia and its clinical correlates in a general population in Turkey.

Author: Benbir G, Demir AU, Aksu M, Ardic S, Firat H, Itil O, Ozgen F, Yılmaz H, and Karadeniz D
Subjects: Adolescent, Adult, Age Factors, Aged, Comorbidity, Female, Health Surveys, Humans, Male, Middle Aged, Prevalence, Risk Factors, Turkey epidemiology, Young Adult, Heart Diseases epidemiology, Sleep Initiation and Maintenance Disorders epidemiology
Abstract: Aim: The prevalence of insomnia is influenced by environmental factors. This study aimed to investigate the prevalence of insomnia and its sociodemographic and clinical correlates in a general population-based survey in Turkey., Methods: This population-based study included 4758 subjects among 5021 who participated in the Turkish Adult Population Epidemiology of Sleep Disorders study. Questionnaire items evaluating insomnia were adapted from the International Classification of Sleep Disorders II and the DSM-IV-TR. Subjects with restless legs syndrome were excluded., Results: Insomnia was found to be associated with older age (18-24 years, 9.8%; 25-44 years, 11.7%; 45-64 years, 13.8%; 65 years or older, 13.9%), lower income level (<500 USD, 16.5%), time spent watching TV (6-8 h or more, 18.4%), tea consumption in the evening (≥6 glasses, 14.5%) and smoking status (current and ex-smoker, both 14.2%) in multiple logistic regression analysis. In respect to other medical disorders, insomnia was significantly associated with the presence of hypertension, diabetes and heart diseases after the adjustment for relevant risk factors for each disease, across all age and sex groups., Conclusions: Insomnia is a major health problem in our population, affecting subjects in the working age group and those of lower socioeconomic status. It should especially be screened in patients with chronic diseases. A relatively low proportion of insomnia diagnosed as a sleep disorder suggests that this condition and its clinical correlates are possibly under-recognized., (© 2014 The Authors. Psychiatry and Clinical Neurosciences © 2014 Japanese Society of Psychiatry and Neurology.)
Published: 2015
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39. Creatine kinase-MB may lead to confusion in the ED.

Author: Sarlak H, Tanriseven M, Ardic S, and Duran E
Subjects: Female, Humans, Male, Acute Coronary Syndrome diagnosis, Creatine Kinase, MB Form blood, Diagnostic Tests, Routine economics
Published: 2015
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40. Ozone therapy ameliorates paraquat-induced lung injury in rats.

Author: Kaldirim U, Uysal B, Yuksel R, Macit E, Eyi YE, Toygar M, Tuncer SK, Ardic S, Arziman I, Aydin I, Oztas Y, Karslioglu Y, and Topal T
Subjects: Animals, Blood Chemical Analysis, Female, Injections, Intraperitoneal, Lung pathology, Rats, Sprague-Dawley, Treatment Outcome, Anti-Inflammatory Agents therapeutic use, Antioxidants therapeutic use, Lung Injury chemically induced, Lung Injury therapy, Oxidants toxicity, Ozone therapeutic use, Paraquat toxicity
Abstract: Paraquat (PQ) overdose can cause acute lung injury and death. Ozone therapy (OT) was previously demonstrated to alleviate inflammation and necrosis in various pathologies. We therefore hypothesized that OT has ameliorative and preventive effects on PQ-induced lung damage due to anti-inflammatory and antioxidants properties. Sprague-Dawley rats (n = 24) were separated into three groups: sham, PQ, and PQ+OT groups. 15 mg/kg PQ was administered intraperitoneally in PQ and PQ+OT groups to induce experimental lung injury. One hour after PQ treatment, PQ+OT group was administered a single dose of ozone-oxygen mixture (1 mg/kg/day) by intraperitoneal route for four consecutive days. The animals were sacrificed on fifth day after PQ administration. Blood samples and lung tissues were collected to evaluate the inflammatory processes, antioxidant defense and pulmonary damage. Serum lactate dehydrogenase (LDH) and neopterin levels, tissue oxidative stress parameters, total TGF-β1 levels, and histological injury scores in PQ+OT group were significantly lower than PQ group (P<0.05, PQ vs. PQ+OT). Total antioxidant capacity in PQ+OT group was significantly higher than PQ group (P < 0.05, PQ+OT vs. PQ). These findings suggest that outcome in PQ-induced lung injury may be improved by using OT as an adjuvant therapy., (© 2014 by the Society for Experimental Biology and Medicine.)
Published: 2014
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41. No suspicion, no disease! renal infarction: case series.

Author: Karacabey S, Hocagil H, Sanri E, Hocagil AC, Ardic S, and Suman E
Subjects: Abdominal Pain diagnosis, Abdominal Pain etiology, Aged, 80 and over, Diagnosis, Differential, Female, Flank Pain diagnosis, Flank Pain etiology, Humans, Kidney Function Tests, Male, Middle Aged, Radiographic Image Enhancement methods, Tomography, X-Ray Computed methods, Treatment Outcome, Ultrasonography, Doppler methods, Diagnostic Errors prevention & control, Fibrinolytic Agents therapeutic use, Infarction diagnosis, Infarction etiology, Infarction physiopathology, Kidney blood supply, Nephrolithiasis diagnosis, Pyelonephritis diagnosis, Renal Artery Obstruction complications, Renal Artery Obstruction diagnosis, Renal Artery Obstruction drug therapy, Renal Artery Obstruction surgery, Vascular Grafting methods
Published: 2014

42. Novel use of ultrasound in the ED: ultrasound-guided hematoma block of a proximal humeral fracture.

Author: Kaldırım U, Yolcu U, Ardic S, and Bilgic S
Subjects: Female, Humans, Radiography, Hematoma diagnostic imaging, Humeral Fractures diagnostic imaging, Nerve Block methods, Ultrasonography, Interventional
Published: 2014
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43. The utility of neck/thyromental ratio in defining low-risk patients with obstructive sleep apnea in sleep clinics.

Author: Yuceege M, Firat H, Altintas N, Mutlu M, and Ardic S
Subjects: Body Mass Index, Female, Humans, Male, Middle Aged, Polysomnography, Predictive Value of Tests, Prospective Studies, ROC Curve, Sleep Apnea, Obstructive physiopathology, Surveys and Questionnaires, Anthropometry methods, Hospitals, Special, Neck anatomy & histology, Sleep physiology, Sleep Apnea, Obstructive diagnosis, Thyroid Gland anatomy & histology
Abstract: We aimed to evaluate the importance of neck/thyromental distance in the diagnosis of moderate to severe obstructive sleep apnea (OSA) in sleep clinics. 185 patients (122 males, 63 females) referred to our sleep clinic with OSA symptoms were enrolled to the study. The patients had level-1 polysomnography (PSG). The neck circumference (N), thyromental distance (T), and STOP test were recorded in all patients. Using an obstructive AHI > 15 event/h on PSG as the cut-off, the best N/T ratio to find patients with OSA was calculated with the receiver operator curve analyses. The best cut-off for N/T was chosen as 4.6. We used Modified STOP test: STO-NT test in which P (for hypertension item) was replaced with N/T ratio. N/T ratio >4.6 was scored as "positive". Two positives out of four questions in STO-NT were scored as high risk for OSA. The OSA prevalence was 60 % for AHI > 15. The mean ratio of N/T was significantly different between groups with AHI > 15 and AHI ≤ 15. N and N/T ratio were moderately correlated with AHI. Sensitivity, specificity, negative predictive value, positive predictive value, and negative likelihood ratio of STOP test for AHI > 15 were 88.5, 28.4, 61.8, 65.4 % and 0.40, whereas 97.3, 23, 85, 65.9 % and 0.12 for STO-NT test, respectively. STO-NT test seems better than STOP test in determining patients who do not likely to have moderate to severe OSA in sleep clinics so can be preferred to decide on therapies other than CPAP in a short time.
Published: 2014
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44. Changes in serum levels of MDA and MMP-9 after UPF in patients with OSAS.

Author: Vuralkan E, Mutlu M, Firat IH, Akaydin S, Sagit M, Akin I, Miser E, and Ardic S
Subjects: Adult, Female, Follow-Up Studies, Humans, Male, Middle Aged, Postoperative Complications diagnosis, Sleep Apnea, Obstructive diagnosis, Treatment Outcome, Malondialdehyde blood, Matrix Metalloproteinase 9 blood, Palate surgery, Polysomnography, Postoperative Complications blood, Sleep Apnea, Obstructive blood, Sleep Apnea, Obstructive surgery, Surgical Flaps, Uvula surgery
Abstract: The aim of the study was to assess the markers of oxidant-antioxidant status in patients with obstructive sleep apnea syndrome (OSAS) who underwent uvulopalatal flap (UPF) surgery. Twenty-five patients who underwent UPF surgery participated in this study. Polysomnographic examinations were performed before and after the surgery to assess sleep apnea in all patients and to determine the success of the UPF surgery regarding the improvement in the apnea-hypopnea index (AHI). Descriptive factors (BMI, age, gender and neck thickness, etc.) of patients were recorded before operation. Blood samples were taken preoperatively, and repeated postoperatively at 6-month intervals to determine the changes in serum malondialdehyde (MDA) and matrix metalloproteinase-9 (MMP-9) levels. The mean age at surgery was 45.6 ± 9.9 years (range 25-63 years). There was a significant difference between preoperative and postoperative AHI, MDA and MMP-9 values (p < 0.05). There was no significant correlation between categorical variables. There was no correlation between postoperative ODI, MMP-9 and MDA. These results indicate that OSAS is associated with abnormal lipid peroxidation, which can be improved by UPF surgery. OSAS may increase risks of cardiovascular morbidity; however, UPF might be useful for decreasing these risks in patients with OSAS who are suitable candidates for UPF surgery.
Published: 2014
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45. Long-term effects of PAP on ocular surface in obstructive sleep apnea syndrome.

Author: Acar M, Firat H, Yuceege M, and Ardic S
Subjects: Adult, Aged, Aged, 80 and over, Corneal Diseases diagnosis, Double-Blind Method, Dry Eye Syndromes diagnosis, Eyelid Diseases diagnosis, Female, Fluorophotometry, Follow-Up Studies, Humans, Male, Middle Aged, Polysomnography, Prospective Studies, Sleep Apnea, Obstructive diagnosis, Surveys and Questionnaires, Tears chemistry, Young Adult, Continuous Positive Airway Pressure adverse effects, Corneal Diseases etiology, Dry Eye Syndromes etiology, Eyelid Diseases etiology, Sleep Apnea, Obstructive therapy
Abstract: Objective: To assess the long-term effects of positive airway pressure (PAP) therapy on the ocular surface and eyelid in patients with obstructive sleep apnea hypopnea syndrome (OSAHS)., Design: Single-centred, prospective, and double-blinded study., Participants: Fifty-one patients with OSAHS., Methods: Fifty-one patients with OSAHS were treated with PAP for a period of 18 months. The pre- and post-PAP values for eye examination scores (presence of floppy eyelid syndrome [FES], results of the Ocular Surface Disease Index [OSDI] questionnaire, Schirmer I test, tear film break-up time [TBUT] values, and corneal staining stages) were compared., Results: Based on the apnea-hypopnea index, 17 patients were followed with moderate and 34 patients were followed with severe OSAHS. The presence of FES before and after PAP was 56.9% and 74.5% (p < 0.01). FES stage was determined as 1.41 ± 0.98 before PAP and 0.78 ± 0.78 after PAP (p < 0.01). Pre-PAP and post-PAP OSDI results were 47.79 ± 21.04 and 42.17 ± 19.97, respectively (p < 0.01). Schirmer values before and after PAP were 7.23 ± 1.95 and 8.49 ± 1.79 mm, respectively (p < 0.01). TBUT values before and after PAP were 7.11 ± 1.82 and 8.68 ± 1.76 seconds, respectively (p < 0.01). Scores of the corneal staining stages before and after PAP were 1.05 ± 0.75 and 0.68 ± 0.54, respectively (p < 0.01)., Conclusions: OSAHS is associated with low Schirmer and TBUT values, and high scores in OSDI questionnaire, and high corneal staining stage. An appropriate PAP therapy helps to relieve both the systemic findings and the ocular surface problems most likely by providing a return to normal sleep patterns. We believe that long-term (at least 1 year) use of PAP improves the clinical picture of FES and can overcome the problem of ocular irritation that is encountered in the early stage of PAP., (Copyright © 2014 Canadian Ophthalmological Society. Published by Elsevier Inc. All rights reserved.)
Published: 2014
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46. Influence of gender on C-reactive protein, fibrinogen, and erythrocyte sedimentation rate in obstructive sleep apnea.

Author: Yardim-Akaydin S, Caliskan-Can E, Firat H, Ardic S, and Simsek B
Subjects: Adult, Blood Sedimentation, Female, Humans, Inflammation immunology, Inflammation Mediators metabolism, Male, Middle Aged, Oxygen metabolism, Polysomnography, Respiration, C-Reactive Protein metabolism, Fibrinogen metabolism, Sex Factors, Sleep Apnea, Obstructive immunology
Abstract: Inflammation is one of the pathophysiological pathways suggested for the development of cardiovascular disease in obstructive sleep apnea (OSA). The recurrent nocturnal episodes of hypoxia/reoxygenation observed in patients with OSA appear to be partly responsible for the systemic inflammatory response. The aim of this study was to investigate the role of inflammation by measuring the C-reactive protein (CRP) and fibrinogen levels, and erythrocyte sedimentation rate (ESR) in the OSA according to gender. This study included 139 apparently healthy subjects with newly diagnosed OSA and 27 control subjects who underwent overnight polysomnography and routine blood tests. Levels of inflammatory markers (CRP, fibrinogen, and ESR) were determined from the blood samples taken in the morning. The levels of CRP and fibrinogen were significantly higher in patients than in controls (p<0.0001 and p=0.001, respectively). Fibrinogen and ESR were significantly higher in the female patients than in the male patients (p<0.0001). In female patients, CRP and ESR correlated with time spent at oxygen saturation (T%SaO2)<90 (R=0.327, p=0.029 and R=0.301, p=0.05, respectively), T%SaO2<85 (R=0.482, p=0.001 and R=0.409, p=0.006, respectively), oxygen desaturation index (ODI) (R=0.298, p=0.047 and R=0.340, p=0.026, respectively), lowest oxygen saturation (SaO2) (R=-0.293, p=0.051 and R=-0.374, p=0.013, respectively), mean SaO2 (R=-0.408, p=0.005 and R=-0.385, p=0.011, respectively). In male patients, CRP correlated with T%SaO2<90 (R=0.267, p=0.009), T%SaO2<85 (R=0.279, p=0.006), mean SaO2 (R=-0.284, p=0.006) and fibrinogen correlated with T%SaO2<90 (R=0.282, p=0.028), and mean SaO2 (R=-0.252, p=0.05). In conclusion, increased values of systemic inflammatory markers and their correlations with sleep data observed in our study support other studies suggesting the possible involvement of inflammation in OSA. As this correlation is more apparent in female patients then the males, it suggests that there may be a stronger relation between OSA development and inflammation in females. Higher levels of CRP, fibrinogen, and ESR may result from the combined interactions of obesity, metabolic syndrome (MetS) and nocturnal hypoxia.
Published: 2014
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47. Other inflammatory indicators should be kept in mind when assessing red cell distribution width in patients with pneumonia.

Author: Balta S, Demirkol S, Hatipoglu M, Ardic S, Aydogan M, and Celik T
Subjects: Female, Humans, Male, Community-Acquired Infections blood, Community-Acquired Infections mortality, Erythrocyte Indices, Pneumonia blood, Pneumonia mortality
Published: 2013
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48. Red cell distribution width is a predictor of mortality in patients with severe sepsis and septic shock.

Author: Balta S, Demirkol S, Hatipoglu M, Ardic S, Arslan Z, and Celik T
Subjects: Female, Humans, Male, Erythrocyte Indices, Sepsis mortality
Published: 2013
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49. Red cell distribution width: a novel and simple predictor of mortality in acute pancreatitis.

Author: Balta S, Demirkol S, Cakar M, Ardic S, Celik T, and Demirbas S
Subjects: Female, Humans, Male, Erythrocyte Indices, Pancreatitis mortality
Published: 2013
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50. Ocular surface assessment in patients with obstructive sleep apnea-hypopnea syndrome.

Author: Acar M, Firat H, Acar U, and Ardic S
Subjects: Adult, Double-Blind Method, Female, Humans, Male, Middle Aged, Polysomnography, Prospective Studies, Blepharoptosis diagnosis, Corneal Topography, Sleep Apnea, Obstructive diagnosis, Sleep Apnea, Obstructive physiopathology, Tears physiology
Abstract: Purpose: The aim of this study was to assess the correlation between ocular surface changes and disease severity in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS)., Methods: Two hundred eighty patients with OSAHS were compared with respect to the presence of a floppy eyelid syndrome (FES), Ocular Surface Disease Index (OSDI) questionnaire, the corneal fluorescein staining stages, the Schirmer I test, and tear film break-up time (TBUT) values., Results: Based on the apnea-hypopnea index, the presence of FES was detected at the following rates: 23.1 % in non-OSAHS group (A), 41.7 % in mild group (B), 66.7 % in moderate group (C), and 74.6 % in severe group (D); severe and moderate stage of FES was found in groups C and D and mild stage of FES in group B (p < 0.01). OSDI questionnaire values were as follows: group A, 12.57 ± 17.64; group B, 22.90 ± 16.78; group C, 45.94 ± 22.03; and group D, 56.68 ± 22.85(p < 0.01). Schirmer values were as follows: group A, 10.76 ± 3.58 mm; group B, 9.83 ± 2.53 mm; group C, 7.73 ± 2.42 mm; and group D, 6.97 ± 2.15 mm (p < 0.01). The TBUT values were as follows: group A, 10.53 ± 3.64 s; group B, 9.46 ± 2.40 s; group C, 7.29 ± 2.13 s; and group D, 6.82 ± 2.20 s (p < 0.01). Corneal staining scores are as follows: 0.26 ± 0.60 in group A, 0.40 ± 0.71 in group B, 0.98 ± 0.72 in group C, and 1.14 ± 0.90 in group D, and the differences were statistically significant among the groups(p < 0.01)., Discussion: OSAHS, particularly the moderate and severe forms, is associated with low Schirmer and TBUT values and high scores in OSDI questionnaire and corneal staining pattern stage. The presence of FES is observed as a practically constant finding in OSAHS. If complaints such as burning, stinging, and itching which can be commonly observed in middle-aged patients are accompanied by FES, the patient should be evaluated for sleep disorders. We speculate that appropriate treatment of OSAHS may result in better control of these symptoms.
Published: 2013
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