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1,179 results on '"Ardanaz, E."'

1. The age-dependent association of risk factors with pancreatic cancer

Author

Amundadottir, L.T., Ardanaz, E., Arslan, A.A., Beane-Freeman, L.E., Bracci, P.M., Bueno-de-Mesquita, B., Du, M., Gallinger, S., Giles, G.G., Goodman, P.J., Katzke, V.A., Klein, A.P., Kooperberg, C., Kraft, P., Li, D., Malats, N., Marchand, L.L., McCullough, M.L., Milne, R.L., Neoptolemos, J.P., Perdomo, S., Petersen, G.M., Risch, H.A., Shu, X.O., Stolzenberg-Solomon, R.Z., Van Den Eeden, S.K., Visvanathan, K., White, E., Wolpin, B.M., Zheng, W., Yuan, C., Kim, J., Wang, Q.L., Lee, A.A., Babic, A., Perez, K., Ng, K., Giovannucci, E.L., and Stampfer, M.J.

Published
2022
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2. P026 Differential effects of tofacitinib on macrophage activation may contribute to lack of response in ulcerative colitis patients

Author

Melón-Ardanaz, E, primary, Veny, M, additional, Corraliza, A M, additional, Garrido-Trigo, A, additional, Gudiño, V, additional, Moro, M, additional, Sanzo-Machuca, Á, additional, Esteller, M, additional, Masamunt, M C, additional, Caballol, B, additional, Ordás, I, additional, Fernández-Clotet, A, additional, Ricart, E, additional, Panés, J, additional, and Salas, A, additional

Published
2024
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3. DOP45 Blood-derived neutrophils give rise to differentially activated populations in the mucosa of active Inflammatory Bowel Disease patients

Author

Veny, M, primary, Sanzo-Machuca, A, additional, Corraliza, A M, additional, Strobbe, F, additional, Garrido-Trigo, A, additional, Gudiño, V, additional, Melón-Ardanaz, E, additional, Esteller, M, additional, Teubel, I, additional, Masamunt, M C, additional, Ordás, I, additional, Prieto, C, additional, Giner, À, additional, Martin-Cardona, A, additional, Esteve, M, additional, Ricart, E, additional, and Salas, A, additional

Published
2024
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5. Differences in the management and survival of metastatic colorectal cancer in Europe. A population-based study

Author

Van Eycken, L., Henau, K., Grozeva, T., Valerianova, Z., Innos, K., Mägi, M., Bouvier, V., Launoy, G., Robaszkiewicz, M., Bouvier, A.M., Jooste, V., Babaev, V., Katalinic, A., Ólafsdóttir, E.J., Tryggvadóttir, L., Amati, C., Baili, P., Bonfarnuzzo, S., Margutti, C., Meneghini, E., Minicozzi, P., Moretti, G., Sant, M., Cirilli, C., Carrozzi, G., Spata, E., Tumino, R., Rossi, P. Giorgi, Vicentini, M., Stracci, F., Bianconi, F., Contiero, P., Tagliabue, G., Kycler, W., Oko, M., Macek, P., Smok-Kalwat, J., Bielska-Lasota, M., Bento, M.J., Rodrigues, J, Mayer-da-Silva, A., Miranda, A., Primic-Žakelj, M., Jarm, K., Almar, E., Mateos, A., Bidaurrazaga, J., de la Cruz, M., Alberich, C., Torrella-Ramos, A., García, J.M. Díaz, Marcos-Navarro, AI, Carmona-Garcia, C., Marcos-Gragera, R., Luque-Fernandez, M.A., Sánchez-Pérez, M.J., Ardanaz, E., Guevara, M., Bouchardy, C., Fournier, E., Bouvier, Anne-Marie, Jooste, Valérie, Sanchez-Perez, Maria José, Bento, Maria José, Rocha Rodrigues, Jessica, Marcos-Gragera, Rafael, Carmona-Garcia, Maria Carmen, Luque-Fernandez, Miguel Angel, Minicozzi, Pamela, Bouvier, Véronique, Innos, Kaire, and Sant, Milena

Published
2021
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6. Comorbidities, timing of treatments, and chemotherapy use influence outcomes in stage III colon cancer: A population-based European study

Author

Van Eycken, L., Henau, K., Grozeva, T., Valerianova, Z., Innos, K., Mägi, M., Bouvier, V., Launoy, G., Jooste, V., Normand, S., Robaszkiewicz, M., Bouvier, A.-M., Faivre, J., Babaev, V., Katalinic, A., Ólafsdóttir, E.J., Tryggvadóttir, L., Amati, C., Baili, P., Bonfarnuzzo, S., Meneghini, E., Minicozzi, P., Moretti, G., Sant, M., Cirilli, C., Carrozzi, G., Spata, E., Tumino, R., Giorgi Rossi, P., Vicentini, M., Stracci, F., Bianconi, F., Contiero, P., Tagliabue, G., Kycler, W., Oko, M., Macek, P., Smok-Kalwat, J., Bielska-Lasota, M., Bento, M.J., Castro, C., Mayer-da-Silva, A., Miranda, A., Primic Žakelj, M., Jarm, K., Almar, E., Mateos, A., Bidaurrazaga, J., de la Cruz, M., Alberich, C., Torrella-Ramos, A., Marcos Navarro, A.I., Jiménez Chillarón, R., Carmona-Garcia, M.C., Marcos-Gragera, R., Rodriguez-Barranco, M., Sánchez, M.J., Ardanaz, E., Guevara, M., Bouchardy, C., Fournier, E., Minicozzi, Pamela, Vicentini, Massimo, Innos, Kaire, Castro, Clara, Guevara, Marcela, Stracci, Fabrizio, Carmona-Garcia, M<ce:sup loc='post">a</ce:sup>Carmen, Rodriguez-Barranco, Miguel, Vanschoenbeek, Katrijn, Rapiti, Elisabetta, Katalinic, Alexander, Marcos-Gragera, Rafael, Van Eycken, Liesbet, Sánchez, Maria José, Bielska-Lasota, Magdalena, Rossi, Paolo Giorgi, and Sant, Milena

Published
2020
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7. The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case–control and Mendelian randomization study in the European prospective investigation into cancer and nutrition

Author

Smith Byrne, K., Appleby, P.N., Key, T.J., Holmes, M.V., Fensom, G.K., Agudo, A., Ardanaz, E., Boeing, H., Bueno-de-Mesquita, H.B., Chirlaque, M.D., Kaaks, R., Larrañaga, N., Palli, D., Perez-Cornago, A., Quirós, J.R., Ricceri, F., Sánchez, M.J., Tagliabue, G., Tsilidis, K.K., Tumino, R., Fortner, R.T., Ferrari, P., Riboli, E., Lilja, H., and Travis, R.C.

Published
2019
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8. Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Author

Obón-Santacana, M, Kaaks, R, Slimani, N, Lujan-Barroso, L, Freisling, H, Ferrari, P, Dossus, L, Chabbert-Buffet, N, Baglietto, L, Fortner, RT, Boeing, H, Tjønneland, A, Olsen, A, Overvad, K, Menéndez, V, Molina-Montes, E, Larrañaga, N, Chirlaque, M-D, Ardanaz, E, Khaw, K-T, Wareham, N, Travis, RC, Lu, Y, Merritt, MA, Trichopoulou, A, Benetou, V, Trichopoulos, D, Saieva, C, Sieri, S, Tumino, R, Sacerdote, C, Galasso, R, Bueno-de-Mesquita, HB, Wirfält, E, Ericson, U, Idahl, A, Ohlson, N, Skeie, G, Gram, IT, Weiderpass, E, Onland-Moret, NC, Riboli, E, and Duell, EJ

Subjects
Biomedical and Clinical Sciences, Nutrition and Dietetics, Nutrition, Clinical Research, Prevention, Cancer, Aetiology, 2.2 Factors relating to the physical environment, Cardiovascular, Acrylamide, Cohort Studies, Diet, Eating, Endometrial Neoplasms, Female, Humans, Middle Aged, Nutritional Status, Prospective Studies, Risk, Risk Factors, Smoking, acrylamide, endometrial cancer, type-I endometrial cancer, cohort, nutrition, Oncology and Carcinogenesis, Public Health and Health Services, Oncology & Carcinogenesis, Oncology and carcinogenesis
Abstract

BackgroundThree prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.MethodsCox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.ResultsNo associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203).ConclusionsDietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.

Published
2014

10. Quality analysis of population-based information on cancer stage at diagnosis across Europe, with presentation of stage-specific cancer survival estimates: A EUROCARE-5 study

Author

Hackl, M., Zielonke, N., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Dušek, L., Zvolský, M., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Bouvier, A.M., Faivre, J., Bossard, N., Uhry, Z., Colonna, M., Stabenow, R., Luttmann, S., Eberle, A., Brenner, H., Nennecke, A., Engel, J., Schubert-Fritschle, G., Heidrich, J., Holleczek, B., Katalinic, A., Clough-Gorr, K., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Maso, L. Dal, De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Knijn, A., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Natali, M., Filiberti, R.A., Marani, E., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Traina, A., Staiti, R., Vitale, F., Cusimano, R., Michiara, M., Tumino, R., Falcini, F., Caiazzo, A.L., Maspero, S., Fanetti, A.C., Zanetti, R., Rosso, S., Rugge, M., Tognazzo, S., Pildava, S., Smailyte, G., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Kępska, K., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Antunes, L., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Almar, E., Mateos, A., Lopez de Munain, A., Larrañaga, N., Torrella-Ramos, A., Díaz García, J.M., Jimenez-Chillaron, R., Marcos-Gragera, R., Vilardell, L., Moreno-Iribas, C., Ardanaz, E., Lambe, M., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Damhuis, R., Otter, R., Coleman, M., Allemani, C., Rachet, B., Rashbass, J., Broggio, J., Verne, J., Gavin, A., Fitzpatrick, D., Huws, D.W., White, C., Minicozzi, Pamela, Innos, Kaire, Sánchez, Maria-José, Trama, Annalisa, Walsh, Paul M., Marcos-Gragera, Rafael, Dimitrova, Nadya, Botta, Laura, Visser, Otto, Rossi, Silvia, Tavilla, Andrea, and Sant, Milena

Published
2017
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11. Geographical variability in survival of European children with central nervous system tumours

Author

Hackl, M., Zielonke, N., Oberaigner, W., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Storm, H., Engholm, G., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Faivre, J., Bossard, N., Uhry, Z., Colonna, M., Clavel, J., Lacour, B., Desandes, E., Brenner, H., Kaatsch, P., Katalinic, A., Garami, M., Jakab, Z., Comber, H., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Sutera Sardo, A., Mancuso, P., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Zucchetto, A., De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Filiberti, R.A., Marani, E., Ricci, P., Pascucci, C., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Usala, M., Vitale, F., Ravazzolo, B., Michiara, M., Merletti, F., Maule, M., Tumino, R., Mangone, L., Di Felice, E., Falcini, F., Iannelli, A., Sechi, O., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Maspero, S., Fanetti, A.C., Candela, P., Scuderi, T., Stracci, F., Bianconi, F., Tagliabue, G., Contiero, P., Rugge, M., Guzzinati, S., Pildava, S., Smailyte, G., Calleja, N., Agius, D., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Bębenek, M., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Castro, C., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Errezola, M., Bidaurrazaga, J., Vicente Raneda, M., Díaz García, J.M., Marcos-Navarro, A.I., Marcos-Gragera, R., Izquierdo Font, A., Sanchez, M.J., Chang, D.Y.L., Navarro, C., Chirlaque, M.D., Moreno-Iribas, C., Ardanaz, E., Peris-Bonet, R., Pardo Romaguera, E., Galceran, J., Carulla, M., Lambe, M., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Aarts, M., Otter, R., Coleman, M., Allemani, C., Rachet, B., Verne, J., Stiller, C., Gavin, A., Donnelly, C., Brewster, D.H., Sánchez, M.-J., and Rutkowski, S.

Published
2017
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12. Survival of 86,690 patients with thyroid cancer: A population-based study in 29 European countries from EUROCARE-5

Author

Hackl, M., Zielonke, N., Van Eycken, E., Henau, K., Valerianova, Z., Dimitrova, N., Sekerija, M., Dušek, L., Zvolský, M., Storm, H., Engholm, G., Mägi, M., Aareleid, T., Malila, N., Seppä, K., Velten, M., Guizard, A.V., Faivre, J., Woronoff, A.S., Tretarre, B., Bossard, N., Uhry, Z., Colonna, M., Molinié, F., Bara, S., Schvartz, C., Lapôtre-Ledoux, B., Grosclaude, P., Stabenow, R., Luttmann, S., Eberle, A., Brenner, H., Nennecke, A., Engel, J., Schubert-Fritschle, G., Heidrich, J., Holleczek, B., Katalinic, A., Jónasson, J.G., Tryggvadóttir, L., Comber, H., Mazzoleni, G., Bulatko, A., Buzzoni, C., Giacomin, A., Sutera Sardo, A., Mazzei, A., Ferretti, S., Barchielli, A., Caldarella, A., Gatta, G., Sant, M., Amash, H., Amati, C., Baili, P., Berrino, F., Bonfarnuzzo, S., Botta, L., Capocaccia, R., Di Salvo, F., Foschi, R., Margutti, C., Meneghini, E., Minicozzi, P., Trama, A., Serraino, D., Zucchetto, A., De Angelis, R., Caldora, M., Carrani, E., Francisci, S., Mallone, S., Pierannunzio, D., Roazzi, P., Rossi, S., Santaquilani, M., Tavilla, A., Pannozzo, F., Busco, S., Filiberti, R.A., Vercelli, M., Ricci, P., Autelitano, M., Spagnoli, G., Cirilli, C., Fusco, M., Vitale, M.F., Usala, M., Vitale, F., Ravazzolo, B., Michiara, M., Tumino, R., Mangone, L., Vicentini, M., Falcini, F., Iannelli, A., Sechi, O., Cesaraccio, R., Piffer, S., Madeddu, A., Tisano, F., Maspero, S., Fanetti, A.C., Zanetti, R., Rosso, S., Candela, P., Scuderi, T., Stracci, F., Rocca, A., Tagliabue, G., Contiero, P., Rugge, M., Tognazzo, S., Pildava, S., Smailyte, G., Calleja, N., Agius, D., Johannesen, T.B., Rachtan, J., Góźdź, S., Mężyk, R., Błaszczyk, J., Bębenek, M., Bielska-Lasota, M., Forjaz de Lacerda, G., Bento, M.J., Castro, C., Miranda, A., Mayer-da-Silva, A., Safaei Diba, C., Primic-Zakelj, M., Errezola, M., Bidaurrazaga, J., Díaz García, J.M., Marcos-Navarro, A.I., Marcos-Gragera, R., Izquierdo Font, A., Sanchez, M.J., Molina, E., Navarro, C., Chirlaque, M.D., Moreno-Iribas, C., Ardanaz, E., Galceran, J., Carulla, M., Lambe, M., Khan, S., Mousavi, M., Bouchardy, C., Usel, M., Ess, S.M., Frick, H., Lorez, M., Herrmann, C., Bordoni, A., Spitale, A., Konzelmann, I., Visser, O., Ho, V., Otter, R., Coleman, M., Allemani, C., Rachet, B., Rashbass, J., Broggio, J., Verne, J., Gavin, A., Donnelly, C., Brewster, D.H., Huws, D.W., White, C., Dal Maso, L., Pacini, F., van Dijk, B.A.C., Larrañaga, N., Rubió-Casadevall, J., Kowalska, A., and Virdone, S.

Published
2017
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13. DOP05 Single-cell RNAseq temporal analysis of ulcerative colitis patients undergoing tofacitinib treatment reveals a shift in myeloid cells towards pro-inflammatory phenotypes in refractory patients

Author

Melón-Ardanaz, E, primary, Veny, M, additional, Corraliza, A M, additional, Garrido-Trigo, A, additional, Esteller, M, additional, Rodrigo, M, additional, Verstockt, B, additional, Vermeire, S, additional, Masamunt, M C, additional, Giner, Á, additional, Ordás, I, additional, Fernández-Clotet, A, additional, Ricart, E, additional, Panés, J, additional, and Salas, A, additional

Published
2023
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14. Cigarette Smoking and Endometrial Cancer Risk:Observational and Mendelian Randomization Analyses

Author

Dimou, N, Omiyale, W, Biessy, C, Viallon, V, Kaaks, R, O'Mara, TA, Aglago, EK, Ardanaz, E, Bergmann, MM, Bondonno, NP, Braaten, T, Colorado-Yohar, SM, Crous-Bou, M, Dahm, CC, Fortner, RT, Gram, IT, Harlid, S, Heath, AK, Idahl, A, Kvaskoff, M, Nøst, TH, Overvad, K, Palli, D, Perez-Cornago, A, Sacerdote, C, Sánchez, M-J, Schulze, MB, Severi, G, Simeon, V, Tagliabue, G, Tjønneland, A, Truong, T, Tumino, R, Johansson, M, Weiderpass, E, Murphy, N, Gunter, MJ, Lacey, B, Allen, NE, Dossus, L, Dimou, N., Omiyale, W., Biessy, C., Viallon, V., Kaaks, R., O'Mara, T. A., Aglago, E. K., Ardanaz, E., Bergmann, M. M., Bondonno, N. P., Braaten, T., Colorado-Yohar, S. M., Crous-Bou, M., Dahm, C. C., Fortner, R. T., Gram, I. T., Harlid, S., Heath, A. K., Idahl, A., Kvaskoff, M., Nost, T. H., Overvad, K., Palli, D., Perez-Cornago, A., Sacerdote, C., Sanchez, M. -J., Schulze, M. B., Severi, G., Simeon, V., Tagliabue, G., Tjonneland, A., Truong, T., Tumino, R., Johansson, M., Weiderpass, E., Murphy, N., Gunter, M. J., Lacey, B., Allen, N. E., and Dossus, L.

Subjects
Epidemiology, ESTROGENS, Polymorphism, Single Nucleotide, BREAST, Article, Cigarette Smoking, Risk Factors, GENETIC-VARIANTS, REGRESSION, Humans, Genetic Predisposition to Disease, Prospective Studies, 11 Medical and Health Sciences, INDEX, Cancer och onkologi, IDENTIFICATION, WOMEN, Public Health, Global Health, Social Medicine and Epidemiology, Mendelian Randomization Analysis, Endometrial Neoplasms, OVERLAP, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Oncology, Cancer and Oncology, OBESITY, Female, SEX-HORMONES, Genome-Wide Association Study
Abstract

Background: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses. Methods: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In twosampleMR analyses, genetic variants robustly associated with lifetime amount of smoking (n ¼ 126 variants) and ever having smoked regularly (n ¼ 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined. Results: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91–1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer. Conclusions: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. Impact: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk., World Health Organization, Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, NIHR Imperial Biomedical Research Centre (BRC), Danish Cancer Society, Ligue Contre le Cancer (France) Institut Gustave Roussy (France) MutuelleGenerale de l'Education Nationale (France), Institut National de la Sante et de la Recherche Medicale (Inserm), Deutsche Krebshilfe German Cancer Research Center (DKFZ) (Germany) German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE) (Germany) Federal Ministry of Education & Research (BMBF), Fondazione AIRC per la ricerca sul cancro Compagnia di San Paolo Consiglio Nazionale delle Ricerche (CNR), Netherlands Government Netherlands Government, World Cancer Research Fund International (WCRF), Netherlands Government, Health Research Fund (FIS) - Instituto de Salud Carlos III (ISCIII) (Spain), Junta de Andalucia, Principality of Asturias Regional Government of Basque Country (Spain) Regional Government of Murcia (Spain) Regional Government of Navarra (Spain) Catalan Institute of Oncology - ICO (Spain), Swedish Cancer Society Swedish Research Council County Council of Skane (Sweden) County Council of Vasterbotten (Sweden), Cancer Research UK 14136 C8221/A29017, UK Research & Innovation (UKRI), Medical Research Council UK (MRC) 1000143 MR/M012190/1 MR/N003284/1 MC-UU_12015/1 MC_UU_00006/ 1, Cancer Research UK C864/A14136 C18281/A29019

Published
2022

15. Association of leukocyte DNA methylation changes with dietary folate and alcohol intake in the EPIC study

Author

Perrier, F., Viallon, V., Ambatipudi, S., Ghantous, A., Cuenin, C., Hernandez-Vargas, H., Chajès, V., Baglietto, L., Matejcic, M., Moreno-Macias, H., Kühn, T., Boeing, H., Karakatsani, A., Kotanidou, A., Trichopoulou, A., Sieri, S., Panico, S., Fasanelli, F., Dolle, M., Onland-Moret, C., Sluijs, I., Weiderpass, E., Quirós, J. R., Agudo, A., Huerta, J. M., Ardanaz, E., Dorronsoro, M., Tong, T. Y. N., Tsilidis, K., Riboli, E., Gunter, M. J., Herceg, Z., Ferrari, P., and Romieu, I.

Published
2019
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16. Cancer survival in adult patients in Spain. Results from nine population-based cancer registries

Author

Chirlaque, M. D., Salmerón, D., Galceran, J., Ameijide, A., Mateos, A., Torrella, A., Jiménez, R., Larrañaga, N., Marcos-Gragera, R., Ardanaz, E., Sant, M., Minicozzi, P., Navarro, C., Sánchez, M. J., Mateos, Antonio, Almar, Enrique, Quirós, José Ramón, Argüelles, Marcial V., Menéndez, Virginia, Rojas, Dolores, Alemán, Araceli, Torrella, Ana, Sabater, Consol, Botella, Paloma, Chico, Matilde, Ripoll, María, Díaz, Cristina, Vicente, Marisa, Fuster, Nieves, Botella, Paloma, Díaz, José María, Jiménez, Rosario, Navarro, Ana Isabel Marcos, Larrañaga, Nerea, Bidaurrazaga, Joseba, Lopez-de-Munain, Arantza, Marcos-Gragera, Rafael, Izquierdo, Àngel, Vilardell, Loreto, Sánchez, María José, Molina-Portillo, Elena, Rodríguez-Barranco, Miguel, Perucha, Josefina, Franch, Paula, Ramos, Maria, Navarro, Carmen, Chirlaque, María Dolores, Salmerón, Diego, Ardanaz, Eva, Guevara, Marcela, Burgui, Rosana, Galceran, Jaume, Ameijide, Alberto, Carulla, Marià, Bigorra, Jàmnica, Bonet, Rafael Peris, Pardo, Elena, and the REDECAN Working Group

Published
2017
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17. Cancer incidence in Spain, 2015

Author

Galceran, J., Ameijide, A., Carulla, M., Mateos, A., Quirós, J. R., Rojas, D., Alemán, A., Torrella, A., Chico, M., Vicente, M., Díaz, J. M., Larrañaga, N., Marcos-Gragera, R., Sánchez, M. J., Perucha, J., Franch, P., Navarro, C., Ardanaz, E., Bigorra, J., Rodrigo, P., Bonet, R. Peris, Mateos, Antonio, Almar, Enrique, Quirós, José Ramón, Argüelles, Marcial V., Rojas, Dolores, Alemán, Araceli, Torrella, Ana, Sabater, Consol, Botella, Paloma, Chico, Matilde, Ripoll, María, Díaz, Cristina, Vicente, Marisa, Fuster, Nieves, Díaz, José María, Jiménez, Rosario, Navarro, Ana Isabel Marcos, Larrañaga, Nerea, Bidaurrazaga, Joseba, Lopez-de-Munain, Arantza, Marcos-Gragera, Rafael, Izquierdo, Àngel, Vilardell, Loreto, Sánchez, María José, Molina-Portillo, Elena, Rodríguez-Barranco, Miguel, Perucha, Josefina, Franch, Paula, Ramos, Maria, Navarro, Carmen, Chirlaque, María Dolores, Salmerón, Diego, Ardanaz, Eva, Guevara, Marcela, Burgui, Rosana, Galceran, Jaume, Ameijide, Alberto, Carulla, Marià, Bigorra, Jàmnica, Bonet, Rafael Peris, Pardo, Elena, and REDECAN Working Group

Published
2017
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19. Clear Improvement in Real-World Chronic Myeloid Leukemia Survival: A Comparison With Randomized Controlled Trials

Author

Vener, C., Rossi, S., Minicozzi, P., Marcos-Gragera, R., Poirel, H. A., Maynadie, M., Troussard, X., Pravettoni, G., De Angelis, R., Sant, M., Hackl, M., Van Eycken, E., Valerianova, Z., Sekerija, M., Pavlou, P., Dusek, L., Storm, H., Magi, M., Innos, K., Malila, N., Pitkaniemi, J., Velten, M., Bouvier, A. M., Jooste, V., Guizard, A. V., Launoy, G., Yonli, S. D., Woronoff, A. S., Nousbaum, J. B., Coureau, G., Monnereau, A., Baldi, I., Hammas, K., Tretarre, B., Colonna, M., Plouvier, S., D'Almeida, T., Molinie, F., Cowppli-Bony, A., Bara, S., Schvartz, C., Defossez, G., Lapotre-Ledoux, B., Grosclaude, P., Luttmann, S., Stabenow, R., Nennecke, A., Kieschke, J., Zeissig, S., Holleczek, B., Katalinic, A., Birgisson, H., Murray, D., Walsh, P. M., Mazzoleni, G., Vittadello, F., Cuccaro, F., Galasso, R., Sampietro, G., Rosso, S., Magoni, M., Ferrante, M., Sardo, A. S., Gambino, M. L., Ballotari, P., Giacomazzi, E., Ferretti, S., Caldarella, A., Manneschi, G., Gatta, G., Baili, P., Berrino, F., Botta, L., Trama, A., Lillini, R., Bernasconi, A., Bonfarnuzzo, S., Didone, F., Lasalvia, P., Del Monego, G., Magri, M. C., Buratti, L., Serraino, D., Dal Maso, L., Capocaccia, R., Demuru, E., Di Benedetto, C., Santaquilani, M., Venanzi, S., Filiberti, R. A., Iacovacci, S., Gennaro, V., Russo, A. G., Spagnoli, G., D'Oro, L. C., Fusco, M., Vitale, M. F., Usala, M., Vitale, F., Michiara, M., Chiranda, G., Cascone, G., Spata, E., Mangone, L., Falcini, F., Cavallo, R., Piras, D., Madeddu, A., Bella, F., Fanetti, A. C., Minerba, S., Candela, G., Scuderi, T., Rizzello, R. V., Stracci, F., Tagliabue, G., Rugge, M., Brustolin, A., Pildava, S., Smailyte, G., Azzopardi, M., Johannesen, T. B., Didkowska, J., Wojciechowska, U., Bielska-Lasota, M., Pais, A., Pontes, J. L., Miranda, A., Diba, C. S., Zadnik, V., Zagar, T., Escudero, C. S. -C., Sureda, P. F., de Munain, A. L., De-La-cruz, M., Rojas, M. D., Aleman, A., Vizcaino, A., Sanchez, M. J., Chirlaque, M. D., Eslava, M. G., Ardanaz, E., Galceran, J., Carulla, M., Bergeron, Y., Bouchardy, C., Mousavi, S. M., Bordoni, A., Visser, O., Rashbass, J., Gavin, A., Morrison, D., and Huws, D. W.

Subjects
Cancer Research, Survival, real-world data, randomized controlled trials (RCTs), tyrosine kinase inhibitor (TKI), population-based studies, Tyrosine kinase inhibitor (TKI), Randomized controlled trials (RCTs), survival, Real-world data, Europe, Oncology, cancer registries, chronic myeloid leukemia (CML), Chronic myeloid leukemia (CML), Cancer registries, Population-based studies
Abstract

This study was funded by the Compagnia di San Paolo, the Cariplo Foundation and the European Commission (grant number 801520 HP-JA-2017, Innovative Partnership for Action Against Cancer, iPAAC Joint Action). The sources of the funding played no role in designing the study, collecting, analyzing, or interpreting the data, writing the report, or deciding whether or not to submit the article for publication. This research was (partially) funded by Italian Ministry of Health "Ricerca Corrente" funds. Tyrosine kinase inhibitors (TKIs) have been improving the prognosis of patients with chronic myeloid leukemia (CML), but there are still large differences in survival among European countries. This raises questions on the added value of results from population-based studies, which use real-world data, compared to results of randomized controlled trials (RCTs) involving patients with CML. There are also questions about the extent of the findings on RCTs effectiveness for patients in the general population. We compare survival data extracted from our previous systematic review and meta-analysis of CML RCTs with the latest updated population-based survival data of EUROCARE-6, the widest collaborative study on cancer survival in Europe. The EUROCARE-6 CML survival estimated in patients (15-64 years) diagnosed in 2000-2006 vs. 2007-2013 revealed that the prognostic improvement highlighted by RCTs was confirmed in real-world settings, too. The study shows, evaluating for the first time all European regions, that the optimal outcome figures obtained in controlled settings for CML are also achievable (and indeed achieved) in real-world settings with prompt introduction of TKIs in daily clinical practice. However, some differences still persist, particularly in Eastern European countries, where overall survival values are lower than elsewhere, probably due to a delayed introduction of TKIs. Our results suggest an insufficient adoption of adequate protocols in daily clinical practice in those countries where CML survival values remain lower in real life than the values obtained in RCTs. New high-resolution population-based studies may help to identify failures in the clinical pathways followed there.

Published
2022

20. The age-dependent association of risk factors with pancreatic cancer

Author

Yuan, C., primary, Kim, J., additional, Wang, Q.L., additional, Lee, A.A., additional, Babic, A., additional, Amundadottir, L.T., additional, Klein, A.P., additional, Li, D., additional, McCullough, M.L., additional, Petersen, G.M., additional, Risch, H.A., additional, Stolzenberg-Solomon, R.Z., additional, Perez, K., additional, Ng, K., additional, Giovannucci, E.L., additional, Stampfer, M.J., additional, Kraft, P., additional, Wolpin, B.M., additional, Ardanaz, E., additional, Arslan, A.A., additional, Beane-Freeman, L.E., additional, Bracci, P.M., additional, Bueno-de-Mesquita, B., additional, Du, M., additional, Gallinger, S., additional, Giles, G.G., additional, Goodman, P.J., additional, Katzke, V.A., additional, Kooperberg, C., additional, Malats, N., additional, Marchand, L.L., additional, Milne, R.L., additional, Neoptolemos, J.P., additional, Perdomo, S., additional, Shu, X.O., additional, Van Den Eeden, S.K., additional, Visvanathan, K., additional, White, E., additional, and Zheng, W., additional

Published
2022
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21. Circulating prolactin and breast cancer risk among pre- and postmenopausal women in the EPIC cohort

Author

Tikk, K., Sookthai, D., Johnson, T., Rinaldi, S., Romieu, I., Tjønneland, A., Olsen, A., Overvad, K., Clavel-Chapelon, F., Baglietto, L., Boeing, H., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Pala, V., Tumino, R., Rosso, S., Panico, S., Agudo, A., Menéndez, V., Sánchez, M.-J., Amiano, P., Huerta Castaño, J.M., Ardanaz, E., Bueno-de-Mesquita, H.B., Monninkhof, E., Onland-Moret, C., Andersson, A., Sund, M., Weiderpass, E., Khaw, K.-T., Key, T.J., Travis, R.C., Gunter, M.J., Riboli, E., Dossus, L., and Kaaks, R.

Published
2014
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22. Physical activity, sex steroid, and growth factor concentrations in pre- and post-menopausal women: a cross-sectional study within the EPIC cohort

Author

Rinaldi, S., Kaaks, R., Friedenreich, C. M., Key, T. J., Travis, R., Biessy, C., Slimani, N., Overvad, K., Østergaard, J. N., Tjønneland, A., Olsen, A., Mesrine, S., Fournier, A., Dossus, L., Lukanova, A., Johnson, T., Boeing, H., Vigl, M., Trichopoulou, A., Benetou, V., Trichopoulos, D., Masala, G., Krogh, V., Tumino, R., Ricceri, F., Panico, S., Bueno-de-Mesquita, H. B., Monninkhof, E. M., May, A. M., Weiderpass, E., Quirós, J. R., Travier, N., Molina-Montes, E., Amiano, P., Huerta, J. M., Ardanaz, E., Sund, M., Johansson, M., Khaw, K. T., Wareham, N., Scalbert, A., Gunter, M. J., Riboli, E., and Romieu, I.

Published
2014

23. Unprocessed red meat and processed meat consumption and risk of stroke in the Spanish cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Amiano, P., Chamosa, S., Etxezarreta, N., Arriola, L., Sanchez, M.-J., Ardanaz, E., Molina-Montes, E., Chirlaque, M.-D., Moreno-Iribas, C., Huerta, J.-M., Egues, N., Navarro, C., Requena, M., Quiros, J.-R., Fonseca-Nunes, A., Jakszyn, P., Gonzalez, C.-A., and Dorronsoro, M.

Subjects
Prepared meats -- Health aspects, Stroke -- Risk factors, Food/cooking/nutrition, Health
Abstract

BACKGROUND/OBJECTIVES: High intakes of unprocessed red or processed meat may increase the risk of stroke. We aimed to examine the association between unprocessed red meat, processed meat and total red meat consumption and risk of total stroke and ischaemic stroke. SUBJECTS/METHODS: Cox proportional hazards regression analyses were conducted based on the data for 41 020 men and women aged 29-69 years at baseline. RESULTS: During a mean follow-up of 13.8 years, 674 incident cases of stroke (531 ischaemic strokes, 79 haemorrhagic strokes, 42 subarachnoid haemorrhages and 22 mixed or unspecified events) were identified. After multiple adjustment, unprocessed red meat, processed meat and total red meat consumption were not correlated with incidence of total stroke or ischaemic stroke in either men or women. The hazard ratios (HRs) for unprocessed red meat and processed meat and risk of total stroke comparing the highest with the lowest quintiles were, respectively, 0.81 (95% confidence interval (CI) 0.54-1.21; P-trend =0.15) and 0.92 (95% CI 0.64-1.32; P-trend = 0.82) in men and 1.21 (95% CI 0.79-1.85; P-trend =0.10) and 0.81 (95% CI 0.51-1.27; P-trend =0.17) in women. The HRs for unprocessed red meat and processed meat and risk of ischaemic stroke were, respectively, 0.80 (95% CI 0.51-1.25; Ptrend = 0.51) and 0.86 (95% CI 0.57-1.29; P-trend =0.77) in men and 1.24 (95% CI 0.74-2.05; P-trend = 0.13) and 0.82 (95% CI 0.471.42; P-trend = 0.31) in women. CONCLUSIONS: In the Spanish European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, unprocessed red meat and processed meat consumption were not associated with risk of stroke in men or women. European Journal of Clinical Nutrition (2016) 70, 313-319; doi: 10.1038/ejcn.2015.150; published online 30 September 2015, INTRODUCTION In recent years, there has been considerable interest in investigating the relationship between protein-rich foods and risk of coronary heart disease (CHD) and stroke. These studies have focused mainly [...]

Published
2016
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29. Fruits and vegetables consumption and the risk of histological subtypes of lung cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC)

Author

Büchner, F. L., Bueno-de-Mesquita, H. B., Linseisen, J., Boshuizen, H. C., Kiemeney, L. A. L. M., Ros, M. M., Overvad, K., Hansen, L., Tjonneland, A., Raaschou-Nielsen, O., Clavel-Chapelon, F., Boutron-Ruault, M.-C., Touillaud, M., Kaaks, R., Rohrmann, S., Boeing, H., Nöthlings, U., Trichopoulou, A., Zylis, D., Dilis, V., Palli, D., Sieri, S., Vineis, P., Tumino, R., Panico, S., Peeters, P. H. M., van Gils, C. H., Lund, E., Gram, I. T., Braaten, T., Martinez, C., Agudo, A., Arriola, L., Ardanaz, E., Navarro, C., Rodríguez, L., Manjer, J., Wirfält, E., Hallmans, G., Rasmuson, T., Key, T. J., Roddam, A. W., Bingham, S., Khaw, K.-T., Slimani, N., Bofetta, P., Byrnes, G., Norat, T., Michaud, D., and Riboli, E.

Published
2010

30. Relationship of Alcohol Intake and Sex Steroid Concentrations in Blood in Pre- and Post-Menopausal Women: The European Prospective Investigation into Cancer and Nutrition

Author

Rinaldi, S., Peeters, P. H. M., Bezemer, I. D., Dossus, L., Biessy, C., Sacerdote, C., Berrino, F., Panico, S., Palli, D., Tumino, R., Khaw, K. T., Bingham, S., Allen, N. E., Key, T., Jensen, M. K., Overvad, K., Olsen, A., Tjonneland, A., Amiano, P., Ardanaz, E., Agudo, A., Martinez-García, C., Quirós, J. Ramón, Tormo, M. J., Nagel, G., Linseisen, J., Boeing, H., Schulz, M., Grobbee, D. E., Bueno-De-Mesquita, H. B., Koliva, M., Kyriazi, G., Thrichopoulou, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Ferrari, P., Slimani, N., Saracci, R., Riboli, E., and Kaaks, R.

Published
2006
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32. A new pipeline for the normalization and pooling of metabolomics data

Author

Viallon, V., His, M., Rinaldi, S., Breeur, M., Gicquiau, A., Hemon, B., Overvad, K., Tjønneland, A., Rostgaard-Hansen, A.L., Rothwell, J.A., Lecuyer, L., Severi, G., Kaaks, R., Johnson, T., Schulze, M.B., Palli, D., Agnoli, C., Panico, S., Tumino, R., Ricceri, F., Monique Verschuren, W.M., Engelfriet, P., Onland-Moret, C., Vermeulen, R., Nøst, T.H., Urbarova, I., Zamora-Ros, R., Rodriguez-Barranco, M., Amiano, P., Huerta, J.M., Ardanaz, E., Melander, O., Ottoson, F., Vidman, L., Rentoft, M., Schmidt, J.A., Travis, R.C., Weiderpass, E., Johansson, M., Dossus, L., Jenab, M., Gunter, M.J., Bermejo, J.L., Scherer, D., Salek, R.M., Keski-Rahkonen, P., Ferrari, P., IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Sub Inorganic Chemistry and Catalysis, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, and Sub Inorganic Chemistry and Catalysis

Subjects
Normalization (statistics), Pooling, Computer science, Pipeline (computing), Endocrinology, Diabetes and Metabolism, computer.software_genre, Microbiology, Biochemistry, Generalized linear mixed model, Statistical power, Article, 03 medical and health sciences, Endocrinology, 0302 clinical medicine, Cancer epidemiology, Metabolites, Metabolomics, Imputation (statistics), Càncer, Molecular Biology, 030304 developmental biology, Cancer, 0303 health sciences, Cancer och onkologi, Bioinformatics (Computational Biology), Normalization, Technical variability, VDP::Medisinske Fag: 700::Helsefag: 800::Samfunnsmedisin, sosialmedisin: 801, Missing data, QR1-502, 3. Good health, Diabetes and Metabolism, Metabolòmica, 030220 oncology & carcinogenesis, Cancer and Oncology, Outlier, Bioinformatik (beräkningsbiologi), Data mining, VDP::Medical disciplines: 700::Health sciences: 800::Community medicine, Social medicine: 801, computer
Abstract

Pooling metabolomics data across studies is often desirable to increase the statistical power of the analysis. However, this can raise methodological challenges as several preanalytical and analytical factors could introduce differences in measured concentrations and variability between datasets. Specifically, different studies may use variable sample types (e.g., serum versus plasma) collected, treated, and stored according to different protocols, and assayed in different laboratories using different instruments. To address these issues, a new pipeline was developed to normalize and pool metabolomics data through a set of sequential steps: (i) exclusions of the least informative observations and metabolites and removal of outliers, imputation of missing data, (ii) identification of the main sources of variability through principal component partial R-square (PC-PR2) analysis, (iii) application of linear mixed models to remove unwanted variability, including samples’ originating study and batch, and preserve biological variations while accounting for potential differences in the residual variances across studies. This pipeline was applied to targeted metabolomics data acquired using Biocrates AbsoluteIDQ kits in eight case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Comprehensive examination of metabolomics measurements indicated that the pipeline improved the comparability of data across the studies. Our pipeline can be adapted to normalize other molecular data, including biomarkers as well as proteomics data, and could be used for pooling molecular datasets, for example in international consortia, to limit biases introduced by inter-study variability. This versatility of the pipeline makes our work of potential interest to molecular epidemiologists.

Published
2021

33. [Family history of first degree as a risk factor for colorectal cancer]

Author

Rubín-García M, Martín V, Vitelli-Storelli F, Moreno V, Aragonés N, Ardanaz E, Alonso-Molero J, Jiménez-Moleón JJ, Amiano P, Fernández-Tardón G, Molina-Barceló A, Alguacil J, Dolores-Chirlaque M, Álvarez-Álvarez L, Pérez-Gómez B, Dierssen-Sotos T, Olmedo-Requena R, Guevara M, Fernández-Villa T, Pollán M, and Benavente Y

Subjects
Factor de riesgo, MCCSpain, Family history, Antecedentes familiares, MCC-Spain, Middle Aged, Colorectal cancer, Case and control, Risk Factors, Spain, Odds Ratio, Humans, Cáncer colorrectal, Family, Risk factor, Casos y controles, Colorectal Neoplasms
Abstract

Objective: To evaluate the association between first-degree family history and colorectal cancer (CRC). Method: We analyzed data from 2857 controls and 1360 CRC cases, collected in the MCC-Spain project. The adjusted odds ratio (OR) and 95% confidence interval (95% CI) of association with the family history of CRC was estimated by non-conditional logistic regression. Result: First-degree relatives doubled the risk of CRC (OR: 2.19; 95% CI: 1.80-2.66), increasing in those with two or more (OR: 4.22; 95% CI: 2.29-7.78) and in those whose relatives were diagnosed before 50 years (OR: 3.24; 95% CI: 1.52-6.91). Regarding the association of the family history with the location, no significant differences were observed between colon and rectum, but there were in the relation of these with the age of diagnosis, having more relatives those diagnosed before 50 years (OR: 4.79; 95% CI: 2.65-8.65). Conclusions: First-degree relatives of CRC increase the chances of developing this tumor, they also increase when the relative is diagnosed at an early age. Therefore, it must be a target population on which to carry out prevention measures. (C) 2021 SESPAS. Published by Elsevier Espana, S.L.U.

Published
2021

34. Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study

Author

Abbas, S, Linseisen, J, Rohrmann, S, Beulens, J W J, Buijsse, B, Amiano, P, Ardanaz, E, Balkau, B, Boeing, H, Clavel-Chapelon, F, Fagherazzi, G, Franks, P W, Gavrila, D, Grioni, S, Kaaks, R, Key, T J, Khaw, K T, Kühn, T, Mattiello, A, Molina-Montes, E, Nilsson, P M, Overvad, K, Quirós, J R, Rolandsson, O, Sacerdote, C, Saieva, C, Slimani, N, Sluijs, I, Spijkerman, A M W, Tjonneland, A, Tumino, R, van der A, D L, Zamora-Ros, R, Sharp, S J, Langenberg, C, Forouhi, N G, Riboli, E, and Wareham, N J

Published
2014
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43. Red blood cell fatty acids and risk of colorectal cancer in the European Prospective investigation into cancer and nutrition (EPIC)

Author

Linseisen, J., Grundmann, N., Zoller, D., Kuhn, T., Chajes, V., Fedirko, V., Weiderpass, E., Dahm, C.C., Overvad, K., Tjønneland, A., Boutron-Ruault, M.-C., Rothwell, J.A., Severi, G., Kaaks, R., Schulze, M.B., Aleksandrova, K., Sieri, S., Panico, S., Tumino, R., Masala, G., de Marco, L., Bueno-De-Mesquita, B., Vermeulen, R., Gram, I.T., Skeie, G., Chirlaque, M.-D., Ardanaz, E., Agudo, A., Sánchez, M.-J., Amiano, P., Wennberg, M., Bodén, S., Perez-Cornago, A., Aglago, E.K., Gunter, M.J., Jenab, M., Heath, A.K., Nieters, A., IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2

Subjects
Oncology, Epidemiology
Abstract

Background: A growing body of evidence suggests that alterations of dietary fatty acid (FA) profiles are associated with colorectal cancer risk. However, data from large-scale epidemiologic studies using circulating FA measurements to objectively assess individual FA and FA categories are scarce. Methods: We investigate the association between red blood cell (RBC) membrane FAs and risk of colorectal cancer in a case–control study nested within a large prospective cohort. After a median follow-up of 6.4 years, 1,069 incident colorectal cancer cases were identified and matched to 1,069 controls among participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). The FA composition of RBC phospholipids (in mol%) was analyzed by gas chromatography, and their association with risk of colorectal cancer was estimated by multivariable adjusted conditional logistic regression models. Results: After correction for multiple testing, subjects with higher concentrations of RBC stearic acid were at higher risk for colorectal cancer (OR ¼ 1.23; 95% CI ¼ 1.07–1.42, per 1 mol%). Conversely, colorectal cancer incidence decreased with increasing proportions of RBC n-3 PUFA, particularly eicosapentaenoic acid (0.75; 0.62–0.92, per 1 mol%). The findings for the n-6 PUFA arachidonic acid were inconsistent. Conclusions: The positive association between prediagnostic RBC stearic acid and colorectal cancer reflects putative differences in FA intake and metabolism between cancer cases and matched controls, which deserve further investigation. The inverse relationship between EPA and colorectal cancer is in line with the repeatedly reported protective effect of fish consumption on colorectal cancer risk. Impact: These findings add to the evidence on colorectal cancer prevention.

Published
2021

44. Healthy lifestyle index and risk of gastric adenocarcinoma in the EPIC cohort study

Author

Buckland, G., Travier, N., Huerta, J. M., Bueno-de-Mesquita, H. B(as), Siersema, P. D., Skeie, G., Weiderpass, E., Engeset, D., Ericson, U., Ohlsson, B., Agudo, A., Romieu, I., Ferrari, P., Freisling, H., Colorado-Yohar, S., Li, K., Kaaks, R., Pala, V., Cross, A. J., Riboli, E., Trichopoulou, A., Lagiou, P., Bamia, C., Boutron-Ruault, M. C., Fagherazzi, G., Dartois, L., May, A. M., Peeters, P. H., Panico, S., Johansson, M., Wallner, B., Palli, D., Key, T. J., Khaw, K. T., Ardanaz, E., Overvad, K., Tjnneland, A., Dorronsoro, M., Sánchez, M. J., Quirós, J. R., Naccarati, A., Tumino, R., Boeing, H., and Gonzalez, C. A.

Published
2015
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45. Diabetes and onset of natural menopause: results from the European Prospective Investigation into Cancer and Nutrition

Author

Brand, J.S., Onland-Moret, N.C., Eijkemans, M.J.C., Tjønneland, A., Roswall, N., Overvad, K., Fagherazzi, G., Clavel-Chapelon, F., Dossus, L., Lukanova, A., Grote, V., Bergmann, M.M., Boeing, H., Trichopoulou, A., Tzivoglou, M., Trichopoulos, D., Grioni, S., Mattiello, A., Masala, G., Tumino, R., Vineis, P., Bueno-de-Mesquita, H.B., Weiderpass, E., Redondo, M.L., Sánchez, M.J., Castaño, J.M. Huerta, Arriola, L., Ardanaz, E., Duell, E.J., Rolandsson, O., Franks, P.W., Butt, S., Nilsson, P., Khaw, K.T., Wareham, N., Travis, R., Romieu, I., Gunter, M.J., Riboli, E., and van der Schouw, Y.T.

Published
2015
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46. Metabolic perturbations prior to hepatocellular carcinoma diagnosis: Findings from a prospective observational cohort study

Author

Stepien, M., Keski-Rahkonen, P., Kiss, A., Robinot, N., Duarte-Salles, T., Murphy, N., Perlemuter, G., Viallon, V., Tjønneland, A., Rostgaard-Hansen, A.L., Dahm, C.C., Overvad, K., Boutron-Ruault, M.-C., Mancini, F.R., Mahamat-Saleh, Y., Aleksandrova, K., Kaaks, R., Kühn, T., Trichopoulou, A., Karakatsani, A., Panico, S., Tumino, R., Palli, D., Tagliabue, G., Naccarati, A., Vermeulen, R.C.H., Bueno-de-Mesquita, H.B., Weiderpass, E., Skeie, G., Ramón Quirós, J., Ardanaz, E., Mokoroa, O., Sala, N., Sánchez, M.-J., Huerta, J.M., Winkvist, A., Harlid, S., Ohlsson, B., Sjöberg, K., Wareham, N., Khaw, K.-T., Ferrari, P., Rothwell, J.A., Gunter, M., Riboli, E., Scalbert, A., Jenab, M., IRAS OH Epidemiology Chemical Agents, and dIRAS RA-2

Subjects
untargeted metabolomics, Cancer Research, prospective observational cohort, Oncology, hepatocellular carcinoma
Abstract

Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose serum concentrations are associated with HCC development, using biological samples from within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (>520 000 participants), where we identified 129 HCC cases matched 1:1 to controls. We conducted high-resolution untargeted liquid chromatography-mass spectrometry-based metabolomics on serum samples collected at recruitment prior to cancer diagnosis. Multivariable conditional logistic regression was applied controlling for dietary habits, alcohol consumption, smoking, body size, hepatitis infection and liver dysfunction. Corrections for multiple comparisons were applied. Of 9206 molecular features detected, 220 discriminated HCC cases from controls. Detailed feature annotation revealed 92 metabolites associated with HCC risk, of which 14 were unambiguously identified using pure reference standards. Positive HCC-risk associations were observed for N1-acetylspermidine, isatin, p-hydroxyphenyllactic acid, tyrosine, sphingosine, l,l-cyclo(leucylprolyl), glycochenodeoxycholic acid, glycocholic acid and 7-methylguanine. Inverse risk associations were observed for retinol, dehydroepiandrosterone sulfate, glycerophosphocholine, γ-carboxyethyl hydroxychroman and creatine. Discernible differences for these metabolites were observed between cases and controls up to 10 years prior to diagnosis. Our observations highlight the diversity of metabolic perturbations involved in HCC development and replicate previous observations (metabolism of bile acids, amino acids and phospholipids) made in Asian and Scandinavian populations. These findings emphasize the role of metabolic pathways associated with steroid metabolism and immunity and specific dietary and environmental exposures in HCC development.

Published
2021

48. Metabolic perturbations prior to hepatocellular carcinoma diagnosis: Findings from a prospective observational cohort study

Author

Stepien, M. Keski-Rahkonen, P. Kiss, A. Robinot, N. Duarte-Salles, T. Murphy, N. Perlemuter, G. Viallon, V. Tjønneland, A. Rostgaard-Hansen, A.L. Dahm, C.C. Overvad, K. Boutron-Ruault, M.-C. Mancini, F.R. Mahamat-Saleh, Y. Aleksandrova, K. Kaaks, R. Kühn, T. Trichopoulou, A. Karakatsani, A. Panico, S. Tumino, R. Palli, D. Tagliabue, G. Naccarati, A. Vermeulen, R.C.H. Bueno-de-Mesquita, H.B. Weiderpass, E. Skeie, G. Ramón Quirós, J. Ardanaz, E. Mokoroa, O. Sala, N. Sánchez, M.-J. Huerta, J.M. Winkvist, A. Harlid, S. Ohlsson, B. Sjöberg, K. Schmidt, J.A. Wareham, N. Khaw, K.-T. Ferrari, P. Rothwell, J.A. Gunter, M. Riboli, E. Scalbert, A. Jenab, M.

Subjects
digestive system diseases
Abstract

Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose serum concentrations are associated with HCC development, using biological samples from within the prospective European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (>520 000 participants), where we identified 129 HCC cases matched 1:1 to controls. We conducted high-resolution untargeted liquid chromatography-mass spectrometry-based metabolomics on serum samples collected at recruitment prior to cancer diagnosis. Multivariable conditional logistic regression was applied controlling for dietary habits, alcohol consumption, smoking, body size, hepatitis infection and liver dysfunction. Corrections for multiple comparisons were applied. Of 9206 molecular features detected, 220 discriminated HCC cases from controls. Detailed feature annotation revealed 92 metabolites associated with HCC risk, of which 14 were unambiguously identified using pure reference standards. Positive HCC-risk associations were observed for N1-acetylspermidine, isatin, p-hydroxyphenyllactic acid, tyrosine, sphingosine, l,l-cyclo(leucylprolyl), glycochenodeoxycholic acid, glycocholic acid and 7-methylguanine. Inverse risk associations were observed for retinol, dehydroepiandrosterone sulfate, glycerophosphocholine, γ-carboxyethyl hydroxychroman and creatine. Discernible differences for these metabolites were observed between cases and controls up to 10 years prior to diagnosis. Our observations highlight the diversity of metabolic perturbations involved in HCC development and replicate previous observations (metabolism of bile acids, amino acids and phospholipids) made in Asian and Scandinavian populations. These findings emphasize the role of metabolic pathways associated with steroid metabolism and immunity and specific dietary and environmental exposures in HCC development. © 2020 UICC

Published
2021

49. Concentrations of bisphenol-A in adults from the general population: A systematic review and meta-analysis

Author

Colorado-Yohar SM, Castillo-González AC, Sánchez-Meca J, Rubio-Aparicio M, Sánchez-Rodríguez D, Salamanca-Fernández E, Ardanaz E, Amiano P, Fernández MF, Mendiola J, Navarro-Mateu F, and Chirlaque MD

Subjects
Serum, Meta-analysis, Endocrine disruptor, Systematic review, Urine, Bisphenol A (BPA)
Abstract

BACKGROUND: Human bisphenol-A (BPA) exposure has been linked to adverse health effects even at low doses, which may be of potential public health concern. OBJECTIVE: To summarize BPA concentrations in general human population and their variability according to sex, geographic area, and analytical method. METHODS: Systematic review and meta-analysis of studies reporting BPA concentrations in adult human populations. Separate meta-analyses of median values were carried out for BPA in serum, creatinine-adjusted urinary BPA, and unadjusted urinary BPA concentrations using a random-effects model. Cochran's Q-statistic, I(2) index, 95% prediction intervals (PIs), between-studies standard deviation (t), and forest plots were applied to verify study heterogeneity. Sensitivity and subgroup analyses and weighted ANOVAs and meta-regressions were conducted. Funnel plots and Egger's tests were used to examine publication bias. RESULTS: Fifteen studies were included in the meta-analysis, totaling 28,353 participants. BPA was detected in over 90% of participants. The pooled creatinine-adjusted urinary BPA concentration was 1.76 µg/g (95% PI: 0.79-2.73), with individual estimates ranging between 1.20 and 2.41. The pooled estimate for unadjusted urinary BPA was 1.91 µg/l (95% PI: 0-3.97), ranging between 0.81 and 3.50, while the pooled estimate for serum BPA was 1.75 µg/l (95% PI: 0-10.58), ranging between 0.34 and 3.76. No differences were found by sex, geographic area or analytical technique. Larger sample sizes were associated with lower BPA concentrations. There was large heterogeneity across studies, whereas data for urinary BPA levels suggested a publication bias affecting research in low exposed populations. CONCLUSION: This first meta-analysis of human BPA concentrations highlights a widespread population exposure to BPA. Although there was high heterogeneity across studies, the expected range of estimated human BPA concentrations suggests that potential health risks are unlikely. Further studies are warranted to better characterize the epidemiology of human BPA exposure, accounting for ethnic, geographic, individual and environmental variability.

Published
2021

50. Lifetime alcohol intake, drinking patterns over time and risk of stomach cancer: A pooled analysis of data from two prospective cohort studies

Author

Jayasekara, H. MacInnis, R.J. Lujan-Barroso, L. Mayen-Chacon, A.-L. Cross, A.J. Wallner, B. Palli, D. Ricceri, F. Pala, V. Panico, S. Tumino, R. Kühn, T. Kaaks, R. Tsilidis, K. Sánchez, M.-J. Amiano, P. Ardanaz, E. Chirlaque López, M.D. Merino, S. Rothwell, J.A. Boutron-Ruault, M.-C. Severi, G. Sternby, H. Sonestedt, E. Bueno-de-Mesquita, B. Boeing, H. Travis, R. Sandanger, T.M. Trichopoulou, A. Karakatsani, A. Peppa, E. Tjønneland, A. Yang, Y. Hodge, A.M. Mitchell, H. Haydon, A. Room, R. Hopper, J.L. Weiderpass, E. Gunter, M.J. Riboli, E. Giles, G.G. Milne, R.L. Agudo, A. English, D.R. Ferrari, P.

Abstract

Alcohol consumption is causally linked to several cancers but the evidence for stomach cancer is inconclusive. In our study, the association between long-term alcohol intake and risk of stomach cancer and its subtypes was evaluated. We performed a pooled analysis of data collected at baseline from 491 714 participants in the European Prospective Investigation into Cancer and Nutrition and the Melbourne Collaborative Cohort Study. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated for incident stomach cancer in relation to lifetime alcohol intake and group-based life course intake trajectories, adjusted for potential confounders including Helicobacter pylori infection. In all, 1225 incident stomach cancers (78% noncardia) were diagnosed over 7 094 637 person-years; 984 in 382 957 study participants with lifetime alcohol intake data (5 455 507 person-years). Although lifetime alcohol intake was not associated with overall stomach cancer risk, we observed a weak positive association with noncardia cancer (HR = 1.03, 95% CI: 1.00-1.06 per 10 g/d increment), with a HR of 1.50 (95% CI: 1.08-2.09) for ≥60 g/d compared to 0.1 to 4.9 g/d. A weak inverse association with cardia cancer (HR = 0.93, 95% CI: 0.87-1.00) was also observed. HRs of 1.48 (95% CI: 1.10-1.99) for noncardia and 0.51 (95% CI: 0.26-1.03) for cardia cancer were observed for a life course trajectory characterized by heavy decreasing intake compared to light stable intake (Phomogeneity =.02). These associations did not differ appreciably by smoking or H pylori infection status. Limiting alcohol use during lifetime, particularly avoiding heavy use during early adulthood, might help prevent noncardia stomach cancer. Heterogeneous associations observed for cardia and noncardia cancers may indicate etiologic differences. © 2021 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.

Published
2021

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