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11. The Comparative Clinical Effects and Safety of Immunoglobulin Replacement Therapy for the Treatment of Primary Immunodeficiency Disorders – A pragmatic review protocol

Author

Di Ruffano, Lavinia Ferrante, Arber, Mick, Orange, Jordan, Carr, Emma, McCool, Rachael, and Reddish, Katie

Subjects
Immune System Diseases, Medicine and Health Sciences, Diseases, Therapeutics, Analytical, Diagnostic and Therapeutic Techniques and Equipment, Chemicals and Drugs
Abstract

People with primary immunodeficiency disorders (PIDDs) require regular infusions with immunoglobulin (Ig) treatments to replenish their naturally low or absent Ig levels, acting as prophylaxis against infection. Ig preparations are produced by numerous manufacturers, who claim differences between the preparations in terms of efficacy and safety. However, to date, these preparations have not been compared with each other. Therefore, we will conduct a pragmatic review of the comparative efficacy and safety of Ig replacement therapies used to treat PIDD. Results of the pragmatic review will be used to inform statistical analyses of named Ig preparations, and if feasible an indirect treatment comparison (ITC) will be conducted. The primary objectives of this project are: 1. To identify and map the evidence-base for the clinical effectiveness and safety of Ig replacement therapies to treat patients with PIDDs. 2. To review and report the clinical effectiveness and safety of different brands of Ig replacement therapies.

Published
2023
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15. A systematic review of cost-utility analyses of screening methods in latent tuberculosis infection in high-risk populations

Author

Mahon, James Matthew, primary, Beale, Sophie, additional, Holmes, Hayden, additional, Arber, Mick, additional, Nikolayevskyy, Vladyslav, additional, Alagna, Riccardo, additional, Manissero, Davide, additional, Dowdy, David, additional, Migliori, Giovanni Battista, additional, Sotgiu, Giovanni, additional, and Duarte, Raquel, additional

Published
2022
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20. Response

Author

Zasowski, Evan J., primary, Bassetti, Matteo, additional, Blasi, Francesco, additional, Rello, Jordi, additional, Sotgiu, Giovanni, additional, Tavoschi, Lara, additional, Arber, Mick R., additional, McCool, Rachael, additional, Patterson, Jacoby V., additional, Longshaw, Christopher M., additional, Lopes, Sara, additional, Manissero, Davide, additional, Nguyen, Sean T., additional, Tone, Keiko, additional, and Aliberti, Stefano, additional

Published
2021
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22. Systematic review of the impact of appropriate versus inappropriate initial antibiotic therapy on outcomes of patients with severe bacterial infections

Author

Bassetti, Matteo, primary, Rello, Jordi, additional, Blasi, Francesco, additional, Goossens, Herman, additional, Sotgiu, Giovanni, additional, Tavoschi, Lara, additional, Zasowski, Evan J., additional, Arber, Mick R., additional, McCool, Rachael, additional, Patterson, Jacoby V., additional, Longshaw, Christopher M., additional, Lopes, Sara, additional, Manissero, Davide, additional, Nguyen, Sean T., additional, Tone, Keiko, additional, and Aliberti, Stefano, additional

Published
2020
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25. Retrospective coding of health care professional cancer screening behaviours and of real-world interventions designed to support them: Identifying recommendations to optimize intervention design.

Author

Hanbury, Andria, Sallis, Anna, Chadborn, Tim, Arber, Mick, Sanderson, Alice, Durlik, Caroline, and Wood, Hannah

Subjects
MEDICAL personnel, EARLY detection of cancer, CANCER treatment, DESIGN science, CANCER patients, NON-coding RNA, HIV-positive women, BEHAVIORAL sciences, MEDICAL screening, BEHAVIOR therapy, RETROSPECTIVE studies, TUMORS
Abstract

Objectives: Screening can detect cancer earlier. Uptake of breast, cervical, and bowel cancer screening in England is below 75%. This study identifies the barriers and facilitators underpinning HCP screening behaviours which can support screening uptake, and reviews the design of real-world interventions targeting these, assessing for congruence between the two. The aim was to provide recommendations to improve the design of interventions.Design and Methods: Barriers/facilitators were identified by a literature review and qualitatively coded using the theoretical domains framework (TDF). Interventions were identified by stakeholders and coded using the behaviour change wheel and the taxonomy of behaviour change techniques. Congruence was assessed through comparing the intervention designs with behavioural science experts' recommendations which link the TDF domains to intervention design. Recommendations targeted missed opportunities.Results: Barriers/facilitators were extracted from 60 papers and most frequently coded to the TDF domains: environmental context and resources, knowledge and beliefs about consequences. Thirty-one interventions were identified, most frequently education, training or enablement functions, delivered via communication/marketing or service provision, and using BCTs designed to shape knowledge or highlight the consequences of or antecedents to screening. Intervention design was largely congruent with recommendations. However, there was less use of persuasion and modelling intervention functions and a reliance on BCTs such as providing instruction when other BCTs could be considered.Conclusions: Recommendations include to consider a broader range of intervention functions and BCTs, particularly for training interventions which should make use of recommended BCTs such as 'graded tasks'. [ABSTRACT FROM AUTHOR]

Published
2021
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26. Additional file 1: Appendix A. of Systematic review and network meta-analysis of tedizolid for the treatment of acute bacterial skin and skin structure infections caused by MRSA

Author

McCool, Rachael, Gould, Ian, Eales, Jacqui, Barata, Teresa, Arber, Mick, Fleetwood, Kelly, Glanville, Julie, and Kauf, Teresa

Abstract

Eligibility criteria. Appendix B. MEDLINE search strategy. Appendix C. Excluded studies. Appendix D. WinBUGS code. Appendix E. Similarity assessment. Appendix F. Results of the random-effects analyses. (DOCX 247Â kb)

Published
2017
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32. Experiences of long-term life-limiting conditions among patients and carers: what can we learn from a meta-review of systematic reviews of qualitative studies of chronic heart failure, chronic obstructive pulmonary disease and chronic kidney disease?

Author

May, Carl R, primary, Cummings, Amanda, additional, Myall, Michelle, additional, Harvey, Jonathan, additional, Pope, Catherine, additional, Griffiths, Peter, additional, Roderick, Paul, additional, Arber, Mick, additional, Boehmer, Kasey, additional, Mair, Frances S, additional, and Richardson, Alison, additional

Published
2016
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