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Abstract Background The screw-in effect is a tendency of a nickel-titanium (NiTi) rotary endodontic file to be pulled into the canal, which can result in a sudden increase in stress leading to instrument fracture, and over-instrumentation beyond the apex. To reduce screw-in force, repeated up-and-down movements are recommended to distribute flexural stress during instrumentation, especially in curved and constricted canals. However, there is no consensus on the optimal number of repetitions. Therefore, this study aimed to examine how repeated up-and-down movements at the working length affect torque/force generation, surface defects, and canal shaping ability of JIZAI and TruNatomy instruments. Methods An original automated root canal instrumentation device was used to prepare canals and to record torque/force changes. The mesial roots of human mandibular molars with approximately 30˚ of canal curvature were selected through geometric matching using micro-computed tomography. The samples were divided into three groups according to the number of up-and-down movements at the working length (1, 3, and 6 times; n = 24 each) and subdivided according to the instruments: JIZAI (#13/0.04 taper, #25/0.04 taper, and #35/0.04 taper) or TruNatomy (#17/0.02 taper, #26/0.04 taper, and #36/0.03 tape) (n = 12 each). The design, surface defects, phase transformation temperatures, nickel-titanium ratios, torque, force, shaping ability, and surface deformation were evaluated. Data were analyzed with the Kruskal-Wallis and Dunn’s tests (α = 0.05). Results The instruments had different designs and phase transformation temperatures. The 3 and 6 up-and-down movements resulted in a smaller upward force compared to 1 movement (p

Background/purpose: Temperature-dependent phase compositional changes influence the mechanical properties of heat-treated nickel-titanium (NiTi) rotary instruments. This study evaluated the phase composition, bending properties, and cyclic fatigue resistance of HyFlex EDM NiTi rotary instruments against differently heat-treated and non-heat-treated NiTi instruments at body temperature (BT). Materials and methods: HyFlex EDM OneFile (EDM) instruments, heat-treated HyFlex CM (CM) and Twisted File (TF) instruments, and non-heat-treated K3 instruments (size #25/.08) were subjected to differential scanning calorimetry, and the martensitic, R-phase, and reverse transformation starting and finishing temperatures were determined. A cantilever bending test and a cyclic fatigue test were conducted at BT (37 °C ± 1.0 °C), and the bending load and number of cycles to failure (NCF) were recorded. Statistical analysis was performed using Kruskal–Wallis and Mann–Whitney U tests (α = 0.05). Results: TF and K3 had reverse transformation finishing temperatures lower than BT, while those for EDM and CM were higher than BT. The bending loads at a 0.5 mm deflection were in the order of EDM

The optimal amplitude of pecking motion during nickel–titanium rotary root canal instrumentation remains unclear. This study evaluated how different pecking amplitudes influence the force/torque generation, canal-centering ability, and cyclic fatigue resistance of the Reciproc Blue R25 instrument. Thirty J-shaped resin canals were instrumented with Reciproc Blue using automated instrumentation and a torque/force sensing device with an up-and-down speed of 50 mm/min and varying pecking amplitudes: Group S (1 s apically, 0.5 s coronally), Group M (2 s apically, 1 s coronally), and Group L (4 s apically, 2 s coronally) (n = 10 each). Force/torque were recorded, and canal-centering ratios were determined. In a dynamic cyclic fatigue test, the Reciproc Blue instruments were rotated in a curved metal canal with 1 mm or 3 mm back-and-forth motions (n = 10 each). Group L exhibited significantly greater maximum downward force and cumulative upward (screw-in) force than Group S (p < 0.05), but torque was not significantly different across groups. Groups M and L exhibited a significantly smaller canal-centering ratio than Group S (p < 0.05). Pecking at 3 mm led to a significantly longer time to fracture and shorter fragment lengths than 1 mm pecking (p < 0.05). In the Reciproc Blue instrumentation, higher pecking amplitude improved canal-centering ability and cyclic fatigue resistance while increasing upward and downward forces.

Background/purpose: The glide path instruments are the introductory instruments into the canals; thus, they should be durable enough to withstand torsional stress/screw-in force. This study aimed to investigate the torque and screw-in force of TruNatomy Glider (TN), ProGLIDER (PG), Hyflex EDM (EDM) and Dent Craft RE (RE) glide path instruments in single- and double-curved canals. Materials and methods: Each instrument brand was divided into two groups (n = 7 each) according to the canal configuration. Torque and screw-in force were recorded during automated instrumentation of simulated resin canals with XSmart IQ cordless motor after the canal patency was checked with a #10 K-file. The values were statistically analyzed using the Kolmogorov-Smirnov test followed by the Kruskal Wallis test and the Mann-Whitney U test with Bonferroni correction (α = 0.05). Results: TN produced significantly higher torque than RE in single-curved canals and PG in double-curved canals (P < 0.05). EDM yielded significantly higher screw-in force than TN and RE in single-curved canals (P < 0.05), but there was no significant difference in double-curved canals (P > 0.05). A significant effect of different canal configurations was only detected for screw-in force in EDM (P

Abstract Background The aim of this study was to evaluate the phase composition, phase transformation temperatures, bending property, and cyclic fatigue resistance of different heat-treated nickel-titanium (NiTi) rotary instruments with the same tip diameter and taper at room (RT; 25 ± 1 °C) and body (BT; 37 ± 1 °C) temperatures. Methods Five heat-treated NiTi rotary instruments, HyFlex EDM (EDM), HyFlex CM (CM), Vortex Blue (VB), RE file CT (RE) and JIZAI, and a non-heat-treated NiTi rotary instrument (Mtwo) with a size 40, 0.04 taper were investigated. Temperature-dependent phase transformation was examined with differential scanning calorimetry (DSC). The bending loads of the instruments at RT and BT were evaluated using a cantilever-bending test. Cyclic fatigue resistance at RT and BT was measured using a dynamic test, during which the instruments were rotated in combination with a 2-mm back-and-forth motion in an artificial curved canal, and the number of cycles to failure (NCF) was determined. The results were analyzed using two-way repeated measures analysis of variance, a simple main effect test, and the Bonferroni test (α = 0.05). Results DSC results indicated that EDM and Mtwo were primarily composed of martensite/R-phase and austenite, respectively, while the other heat-treated instruments were composed of a mix of martensite/R-phase and austenite at the tested temperatures. Regardless of the temperature setting, the bending loads of heat-treated instruments were significantly lower than those of Mtwo (p 0.05). Conclusions Heat-treated NiTi instruments exhibited lower bending loads and higher NCF values than Mtwo. However, this tendency was less pronounced at BT than at RT, especially in the NCF values of instruments with a mixture of martensite/R-phase and austenite phases at the tested temperatures.

Background/purpose: Using conventional approach to examine stationary torque of nickel-titanium rotary instruments contradicts the clinical condition, and its validity for motions involving clockwise and counterclockwise rotations is questionable. This study aimed to examine the effect of different kinematics on the torsional behavior using a JIZAI instrument (#25/.04) under stationary/dynamic test conditions using clinical torque limit settings. Materials and methods: In the stationary test, the 5-mm tip of JIZAI was fixed in a cylinder-shaped vise and rotated in continuous rotation (CR) with auto-torque-reverse, optimum-torque-reverse (OTR), or reciprocation (REC) until fracture (n = 10, each). In the dynamic test, straight and severe curved canals were instrumented with JIZAI using the single-length technique with CR, OTR, or REC (n = 10, each). The stationary torque at fracture, time to fracture (Tf), dynamic torque, and screw-in force were recorded using automated-shaping-device with torque/force measuring unit. One-way ANOVA or Kruskal–Wallis test and Mann–Whitney U test with Bonferroni correction were used for statistical analysis (⍺ = 0.05). Results: The kinematics did not influence the stationary or dynamic torques (P > 0.05); however, did influence the screw-in force in straight canals (P

Abstract Background Unfractionated heparin sodium and nafamostat mesylate have long been used as anticoagulants in continuous kidney replacement therapy (CKRT) where citrate is unavailable. This study aimed to determine whether heparin or nafamostat mesylate used during CKRT was associated with a longer filter life. Methods In this single-centre observational study, we included adult patients who required CKRT and used heparin or nafamostat mesylate for their first CKRT in the intensive care unit from September 1, 2013, to December 31, 2020. The primary outcome was filter life (from the start to the end of using the first filter). We used propensity score matching to adjust for the imbalance in patients’ characteristics and laboratory data at the start of CKRT and compared the outcomes between the two groups. We also performed restricted mean survival time analysis to compare the filter survival times. Results We included 286 patients, 157 patients on heparin and 129 patients on nafamostat mesylate. After propensity score matching, the mean filter life with heparin was 1.58 days (N = 91, Standard deviation [SD], 1.52) and with nafamostat mesylate was 1.06 days (N = 91, SD, 0.94, p = 0.006). Multivariable regression analysis adjusted for confounding factors supported that heparin was associated with a longer filter life compared with nafamostat mesylate (regression coefficient, days, 0.52 [95% CI, 0.15, 0.89]). The between group difference of the restricted mean filter survival time in the matched cohort was 0.29 (95% CI, 0.07–0.50, p = 0.008). Conclusion Compared to nafamostat mesylate, heparin was associated with one-third to one-half a day longer filter life. Trial registration Not applicable.

Abstract Background To evaluate the effect of pecking motions with faster upward speed on the dynamic cyclic fatigue resistance of nickel-titanium rotary instruments with different metallurgy. Methods Forty each of ProTaper Universal F3 (PTU) and ProTaper Gold F3 (PTG) instruments (size #30/.09) were equally divided into four groups. The test was performed using an 18-mm-long stainless steel artificial canal with a 5-mm radius of curvature, a 45° canal curvature and a 2-mm canal diameter. A downward speed of 100 mm/min was employed, while the upward speed was set at 100, 150, 200 or 300 mm/min. Time to failure (Tf), number of cycles to failure (Nf) and number of pecking motions to failure (Np) were recorded. Statistical analysis was performed using Kruskal Wallis and Mann–Whitney U tests for Tf, Nf, and Np (α = 0.05). Results The 100/300 mm/min group showed significantly higher Np values than the 100/100 mm/min group (p

High-performance computing (HPC) cluster systems sometimes adopt a two-layered file system composed of local and global file systems to achieve both capacity and performance in storage. In such a cluster system, the input data of an application needs to be staged from the global storage into the local storage, and the output data needs to be staged from the local storage out to the global storage. This staging operation must be efficiently and quickly performed to gain higher job throughput because an inefficient staging operation prevents waiting job requests from being executed. In particular, in the case of the cluster system with the oversubscribed interconnect shared by the storage and the computing nodes, the inter-node communication and this staging operation traffic collides, which may degrade the job throughput. In this research, we focus on the traffic collision of the inter-node communication and the staging traffic to improve job throughput, targeting the cluster system with the oversubscribed interconnect where these two types of traffic flow. In other words, whether the dynamic control of the traffic flow derived from the staging operation leads to the improvement in the job throughput or not is investigated. For the investigation, we present a traffic collision avoidance method to dynamically configure a set of data paths for each type of the traffic only while the staging operation is conducted. The evaluation in this article shows that the proposed method avoids a traffic collision and accelerates the staging operation by 22.0% on our cluster system. Also, this evaluation indicates the overhead of the application incurred by the proposed method is negligible. Furthermore, 8.7% of the job execution time is reduced by the proposed method.

This study investigated the impact of a one-sided radial-landed cross-sectional design of a heat-treated nickel-titanium rotary instrument (JIZAI, MANI, Japan; JZ) on torque/force generation and canal-shaping ability, using an experimental non-landed instrument (non-landed JZ) for comparison. Both instruments had tip sizes of 25 and 0.04 or 0.06 taper and were similar in metallurgy and geometry, except for the presence/absence of a radial land. Twenty J-shaped simulated resin canals were instrumented in a two-instrument single-length sequence using an automated root canal instrumentation device with a torque/force analyzing unit. Pre- and post-instrumentation images of the resin canals were analyzed for canal-centering ability at 0–3 mm from the apex. The mean centering ratio was not significantly different between JZ and non-landed JZ (p > 0.05). In the 2nd instrumentation, JZ showed a significantly smaller torque compared with the non-landed JZ (p < 0.05). Regardless of instrumentation sequence, JZ showed a significantly smaller maximum upward force, representing screw-in force (p < 0.05), and a larger maximum downward force (p < 0.05) than the non-landed JZ. JZ generated smaller screw-in forces and had similar canal-centering ability compared with the non-landed JZ.

Abstract Background Epithelioid cell granuloma with caseating necrosis is a typical pathological finding in tuberculosis. While specific inflammation, including that related to tuberculosis, can induce caseating granuloma formation, there have been very few reports on the induction of caseating granuloma by non-specific inflammation. Chronic periapical periodontitis is usually related to bacterial biofilm formation as well as fungal or viral infection in the periapical lesion. However, it is difficult to eliminate these extraradicular pathogenic microbes by normal endodontic therapy alone, and more invasive surgical removal is almost always required. Case presentation Here we describe the case of a 30-year-old Japanese woman who had suffered from dull pain related to periapical periodontitis for approximately 10 years. Although the causal tooth had been previously extracted at the Department of Oral Surgery of another hospital in 2015, inflammation of the surrounding tissue had not abated. She was referred to our hospital in May 2016 and underwent surgical debridement via an intra/extraoral approach under general anesthesia. A caseating granuloma accompanied by a small amount of fungi was histopathologically confirmed in the excised specimen. Her inflammation has not been exacerbated since the operation. Conclusions This is the first report in which non-specific inflammation is shown to induce caseating granuloma arising in the jaw. Our report also highlights the importance of sufficient root canal treatment during the first stage of the procedure.

The aim of this review was to provide a detailed literature analysis of torque and force generation during nickel-titanium rotary root canal instrumentation. We followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. An electronic search was performed using in PubMed and in journals for articles published in English from 1987 to June 2020 on studies that investigated dynamic torque and force in vivo or in vitro. We assessed article titles and abstracts to remove duplicates, and the titles and abstracts of the remaining articles were screened for eligibility. Full texts were read to verify eligibility by considering predetermined inclusion and exclusion criteria. Fifty-two out of 4096 studies met the inclusion criteria, from which we identified 26 factors that influence torque or force generation. Factors associated with higher torque or force generation and supported by multiple studies with mostly consistent results included convex triangle cross-sectional design, regressive taper, short pitch length, large instrument size, small canal size, single-length preparation technique, long preparation time, deep insertion depth, low rate of insertion, continuous rotation (torque), reciprocating motion (force), lower rotational speed and conventional alloy. However, several factors are interrelated, which obscured the independent effect of each factor, and there was insufficient scientific evidence supporting the influence of some factors.

1. Zonisamide, an anticonvulsant developed in Japan, is structurally similar to serotonin. Zonisamide has been proven to have a pharmacological profile that is very similar to that of carbamazepine. Thus, the effect of zonisamide was examined in 24 psychiatric patients: 15 with bipolar manic state, 6 with schizoaffective manic state, and 3 schizophrenic excitement. 2. Approximately 25% of all the patients and 33% of the bipolar manic patients showed remarkable global improvement with the addition of zonisamide. Approximately 71% of all the patients and 80% of the bipolar group had more than moderate global improvement. 3. No serious adverse reactions were found and no patients required zonisamide withdrawal. One patient developed both leukocytosis and mildly abnormal liver function test. One developed leukocytosis and another reported mild sleepiness. These reactions disappeared when zonisamide was discontinued.