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19 results on '"Arasaki, Carlos Haruo"'

4. The impact of DNA demethylation on the upregulation of the NRN1 and TNFAIP3 genes associated with advanced gastric cancer

Author

Wisnieski, Fernanda, Santos, Leonardo Caires, Calcagno, Danielle Queiroz, Geraldis, Jaqueline Cruz, Gigek, Carolina Oliveira, Anauate, Ana Carolina, Chen, Elizabeth Suchi, Rasmussen, Lucas Trevizani, Payão, Spencer Luiz Marques, Artigiani, Ricardo, Demachki, Samia, Assumpção, Paulo Pimentel, Lourenço, Laercio Gomes, Arasaki, Carlos Haruo, Pabinger, Stephan, Krainer, Julie, Leal, Mariana Ferreira, Burbano, Rommel Rodriguez, and Arruda Cardoso Smith, Marilia

Published
2020
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5. Genetic and Transcriptional Analysis of 8q24.21 Cluster in Gastric Cancer

Author

PEREIRA, BRUNNO SANTOS, primary, WISNIESKI, FERNANDA, additional, CALCAGNO, DANIELLE QUEIROZ, additional, SANTOS, LEONARDO CAIRES, additional, GIGEK, CAROLINA OLIVEIRA, additional, CHEN, ELIZABETH SUCHI, additional, RASMUSSEN, LUCAS TREVIZANI, additional, PAYÃO, SPENCER LUIZ MARQUES, additional, ALMEIDA, RENATA SANCHES, additional, PINTO, CAMILA ALBUQUERQUE, additional, KARIA, BRUNO TAKAO REAL, additional, ARTIGIANI, RICARDO, additional, DEMACHKI, SAMIA, additional, ASSUMPÇÃO, PAULO PIMENTEL, additional, LOURENÇO, LAERCIO GOMES, additional, ARASAKI, CARLOS HARUO, additional, BURBANO, ROMMEL RODRÍGUEZ, additional, LEAL, MARIANA FERREIRA, additional, and SMITH, MARILIA ARRUDA CARDOSO, additional

Published
2022
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8. Differential regulation of LRRC37A2 in gastric cancer by DNA methylation

Author

Wisnieski, Fernanda, primary, Geraldis, Jaqueline Cruz, additional, Santos, Leonardo Caires, additional, Leal, Mariana Ferreira, additional, Calcagno, Danielle Queiroz, additional, Gigek, Carolina Oliveira, additional, Chen, Elizabeth Suchi, additional, Anauate, Ana Carolina, additional, Artigiani, Ricardo, additional, Demachki, Samia, additional, Assumpção, Paulo Pimentel, additional, Lourenço, Laercio Gomes, additional, Arasaki, Carlos Haruo, additional, Krainer, Julie, additional, Pabinger, Stephan, additional, Burbano, Rommel Rodriguez, additional, and Smith, Marilia Arruda Cardoso, additional

Published
2021
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9. Differential regulation of LRRC37A2 in gastric cancer by DNA methylation.

Author

Wisnieski, Fernanda, Geraldis, Jaqueline Cruz, Santos, Leonardo Caires, Leal, Mariana Ferreira, Calcagno, Danielle Queiroz, Gigek, Carolina Oliveira, Chen, Elizabeth Suchi, Anauate, Ana Carolina, Artigiani, Ricardo, Demachki, Samia, Assumpção, Paulo Pimentel, Lourenço, Laercio Gomes, Arasaki, Carlos Haruo, Krainer, Julie, Pabinger, Stephan, Burbano, Rommel Rodriguez, and Smith, Marilia Arruda Cardoso

Subjects
DNA methylation, STOMACH cancer, GENE expression, REGULATOR genes, ANDROGEN receptors, CARRIER proteins, LEUCINE zippers
Abstract

Gastric cancer (GC) is one of the leading types of fatal cancer worldwide. Epigenetic manipulation of cancer cells is a useful tool to better understand gene expression regulatory mechanisms and contributes to the discovery of novel biomarkers. Our research group recently reported a list of 83 genes that are potentially modulated by DNA methylation in GC cell lines. Herein, we further explored the regulation of one of these genes, LRRC37A2, in clinical samples. LRRC37A2 expression was evaluated by RT-qPCR, and DNA methylation was studied using next-generation bisulphite sequencing in 36 GC and paired adjacent nonneoplastic tissue samples. We showed that both reduced LRRC37A2 mRNA levels and increased LRRC37A2 exon methylation were associated with undifferentiated and poorly differentiated tumours. Moreover, LRRC37A2 gene expression and methylation levels were inversely correlated at the +45 exon CpG site. We suggest that DNA hypermethylation may contribute to reducing LRRC37A2 expression in undifferentiated and poorly differentiated GC. Therefore, our results show how some genes may be useful to stratify patients who are more likely to benefit from epigenetic therapy.Abbreviations: AR: androgen receptor; 5-AZAdC: 5-aza-2'-deoxycytidine; B2M: beta-2-microglobulin; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GC: gastric cancer; GLM: general linear model; LRRC37A2: leucine-rich repeat containing 37 member A2; SD: standard deviation; TFII-I: general transcription factor II-I; TSS: transcription start site; XBP1: X-box binding protein 1 [ABSTRACT FROM AUTHOR]

Published
2022
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12. Differential regulation of LRRC37A2in gastric cancer by DNA methylation

Author

Wisnieski, Fernanda, Geraldis, Jaqueline Cruz, Santos, Leonardo Caires, Leal, Mariana Ferreira, Calcagno, Danielle Queiroz, Gigek, Carolina Oliveira, Chen, Elizabeth Suchi, Anauate, Ana Carolina, Artigiani, Ricardo, Demachki, Samia, Assumpção, Paulo Pimentel, Lourenço, Laercio Gomes, Arasaki, Carlos Haruo, Krainer, Julie, Pabinger, Stephan, Burbano, Rommel Rodriguez, and Smith, Marilia Arruda Cardoso

Abstract

ABSTRACTGastric cancer (GC) is one of the leading types of fatal cancer worldwide. Epigenetic manipulation of cancer cells is a useful tool to better understand gene expression regulatory mechanisms and contributes to the discovery of novel biomarkers. Our research group recently reported a list of 83 genes that are potentially modulated by DNA methylation in GC cell lines. Herein, we further explored the regulation of one of these genes, LRRC37A2, in clinical samples. LRRC37A2expression was evaluated by RT-qPCR, and DNA methylation was studied using next-generation bisulphite sequencing in 36 GC and paired adjacent nonneoplastic tissue samples. We showed that both reduced LRRC37A2mRNA levels and increased LRRC37A2exon methylation were associated with undifferentiated and poorly differentiated tumours. Moreover, LRRC37A2gene expression and methylation levels were inversely correlated at the +45 exon CpG site. We suggest that DNA hypermethylation may contribute to reducing LRRC37A2expression in undifferentiated and poorly differentiated GC. Therefore, our results show how some genes may be useful to stratify patients who are more likely to benefit from epigenetic therapy.Abbreviations:AR: androgen receptor; 5-AZAdC: 5-aza-2'-deoxycytidine; B2M: beta-2-microglobulin; GAPDH: glyceraldehyde-3-phosphate dehydrogenase; GC: gastric cancer; GLM: general linear model; LRRC37A2: leucine-rich repeat containing 37 member A2; SD: standard deviation; TFII-I: general transcription factor II-I; TSS: transcription start site; XBP1: X-box binding protein 1

Published
2022
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13. Identification of suitable reference genes for miRNA expression normalization in gastric cancer

Author

Anauate, Ana Carolina, primary, Leal, Mariana Ferreira, additional, Wisnieski, Fernanda, additional, Santos, Leonardo Caires, additional, Gigek, Carolina Oliveira, additional, Chen, Elizabeth Suchi, additional, Geraldis, Jaqueline Cruz, additional, Calcagno, Danielle Queiroz, additional, Assumpção, Paulo Pimentel, additional, Demachki, Samia, additional, Arasaki, Carlos Haruo, additional, Lourenço, Laércio Gomes, additional, Artigiani, Ricardo, additional, Burbano, Rommel Rodríguez, additional, and Smith, Marília Arruda Cardoso, additional

Published
2017
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19. [Oximetry of stomach: comparative study between proximal gastric vagotomy and anterior lesser curve seromyotomy with posterior truncal vagotomy in chronic duodenal ulcer].

Author

Arasaki CH, Martinez JC, and del Grande JC

Subjects
Analysis of Variance, Biological Clocks, Gastric Fundus innervation, Humans, Stomach innervation, Duodenal Ulcer surgery, Oximetry, Stomach surgery, Vagotomy, Proximal Gastric, Vagotomy, Truncal
Abstract

Unlabelled: Delayed gastric emptying of solid food is greater after proximal gastric vagotomy (PGV) than after anterior lesser curve seromyotomy with posterior truncal vagotomy (ASPTV) and may be due to the hypoxia in the gastric wall and mainly in the gastric pacemaker., Purpose: To verify if operative devascularization of the lesser curve and the gastric fundus could affect the entire stomach and particularly the pacemaker area., Methods: Measures of intraoperative oxyhemoglobin saturation (SpO2) were taken by pulse oximetry on the anterior gastric wall in 20 patients with chronic duodenal ulcer, randomly allocated in two groups of 10 individuals for surgical treatment, by PGV or ASPTV., Results: Measurements, before partial fundoplication, showed that the area of the proximal lesser curve and the gastric fundus had a significant decrease in the SpO2 when compared to the gastric corpus (p < 0,05); the SpO2 was not reduced significantly by the procedures on the pacemaker area; the ligature of short gastric vessels, in association with PGV or ASPTV, reduced significantly the SpO2 (p < 0,05); and, PGV resulted in a SpO2 significantly lower than in ASPTV (p < 0,05)., Conclusion: When PGV is associated with the ligature of the short gastric vessels, it causes acute ischemic changes in the proximal lesser gastric curve and in the fundus more intensively than ASPTV. The gastric pacemaker area does not present hypoxia immediately after operative procedures.

Published
2002
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