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Your search keyword '"Araque Caballero, Miguel Á."' showing total 13 results
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13 results on '"Araque Caballero, Miguel Á."'

6. Within-lesion heterogeneity of subcortical DWI lesion evolution, and stroke outcome: A voxel-based analysis

Author

Duering, Marco, primary, Adam, Ruth, additional, Wollenweber, Frank A, additional, Bayer-Karpinska, Anna, additional, Baykara, Ebru, additional, Cubillos-Pinilla, Leidy Y, additional, Gesierich, Benno, additional, Araque Caballero, Miguel Á, additional, Stoecklein, Sophia, additional, Ewers, Michael, additional, Pasternak, Ofer, additional, and Dichgans, Martin, additional

Published
2019
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7. Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.

Author

Finsterwalder, Sofia, Vlegels, Naomi, Gesierich, Benno, Araque Caballero, Miguel Á., Weaver, Nick A., Franzmeier, Nicolai, Georgakis, Marios K., Konieczny, Marek J., Koek, Huiberdina L., Karch, Celeste M., Graff‐Radford, Neill R., Salloway, Stephen, Oh, Hwamee, Allegri, Ricardo F., Chhatwal, Jasmeer P., Jessen, Frank, Düzel, Emrah, Dobisch, Laura, Metzger, Coraline, and Peters, Oliver

Abstract

Introduction: Microstructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations. Methods: We studied six samples (N = 365 participants) covering the spectrum of AD and SVD, including genetically defined samples. We calculated diffusion measures from DTI and free water imaging. Simple linear, multivariable random forest, and voxel‐based regressions were used to evaluate associations between AD biomarkers (amyloid beta, tau), SVD imaging markers, and diffusion measures. Results: SVD markers were strongly associated with diffusion measures and showed a higher contribution than AD biomarkers in multivariable analysis across all memory clinic samples. Voxel‐wise analyses between tau and diffusion measures were not significant. Discussion: In memory clinic patients, the effect of SVD on diffusion alterations largely exceeds the effect of AD, supporting the value of diffusion measures as markers of SVD. [ABSTRACT FROM AUTHOR]

Published
2020
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8. Left Frontal Hub Connectivity during Memory Performance Supports Reserve in Aging and Mild Cognitive Impairment

Author

Franzmeier, Nicolai, primary, Hartmann, Julia C., additional, Taylor, Alexander N.W., additional, Araque Caballero, Miguel Á., additional, Simon-Vermot, Lee, additional, Buerger, Katharina, additional, Kambeitz-Ilankovic, Lana M., additional, Ertl-Wagner, Birgit, additional, Mueller, Claudia, additional, Catak, Cihan, additional, Janowitz, Daniel, additional, Stahl, Robert, additional, Dichgans, Martin, additional, Duering, Marco, additional, and Ewers, Michael, additional

Published
2017
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13. Small vessel disease more than Alzheimer's disease determines diffusion MRI alterations in memory clinic patients.

Author

Finsterwalder S, Vlegels N, Gesierich B, Araque Caballero MÁ, Weaver NA, Franzmeier N, Georgakis MK, Konieczny MJ, Koek HL, Karch CM, Graff-Radford NR, Salloway S, Oh H, Allegri RF, Chhatwal JP, Jessen F, Düzel E, Dobisch L, Metzger C, Peters O, Incesoy EI, Priller J, Spruth EJ, Schneider A, Fließbach K, Buerger K, Janowitz D, Teipel SJ, Kilimann I, Laske C, Buchmann M, Heneka MT, Brosseron F, Spottke A, Roy N, Ertl-Wagner B, Scheffler K, Seo SW, Kim Y, Na DL, Kim HJ, Jang H, Ewers M, Levin J, Schmidt R, Pasternak O, Dichgans M, Biessels GJ, and Duering M

Subjects
Adult, Aged, Diffusion Magnetic Resonance Imaging, Female, Humans, Male, Middle Aged, Alzheimer Disease diagnostic imaging, Alzheimer Disease pathology, Brain diagnostic imaging, Brain pathology, Cerebral Small Vessel Diseases diagnostic imaging, Cerebral Small Vessel Diseases pathology
Abstract

Introduction: Microstructural alterations as assessed by diffusion tensor imaging (DTI) are key findings in both Alzheimer's disease (AD) and small vessel disease (SVD). We determined the contribution of each of these conditions to diffusion alterations., Methods: We studied six samples (N = 365 participants) covering the spectrum of AD and SVD, including genetically defined samples. We calculated diffusion measures from DTI and free water imaging. Simple linear, multivariable random forest, and voxel-based regressions were used to evaluate associations between AD biomarkers (amyloid beta, tau), SVD imaging markers, and diffusion measures., Results: SVD markers were strongly associated with diffusion measures and showed a higher contribution than AD biomarkers in multivariable analysis across all memory clinic samples. Voxel-wise analyses between tau and diffusion measures were not significant., Discussion: In memory clinic patients, the effect of SVD on diffusion alterations largely exceeds the effect of AD, supporting the value of diffusion measures as markers of SVD., (© 2020 the Alzheimer's Association.)

Published
2020
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