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3. Raman-scattered laser guide star photons to monitor the scatter of astronomical telescope mirrors

Author

Vogt, F. P. A., Álvarez, J. L., Calia, D. Bonaccini, Hackenberg, W., Bourget, P., Aranda, I., Bellhouse, C., Blanchard, I., Cerda, S., Cid, C., Comin, M., Contreras, M. Espinoza, Hau, G., Hibon, P., Holzlöhner, R., Jaffé, Y. L., Kolb, J., Kuntschner, H., Madec, P. -Y., Mieske, S., Milli, J., Opitom, C., Parraguez, D., Romero, C., Selman, F., Schmidtobreick, L., Smoker, J., Urrutia, S. Vera, and Zins, G.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics
Abstract

The first observations of laser guide star photons Raman-scattered by air molecules above the Very Large Telescope (VLT) were reported in June 2017. The initial detection came from the Multi-Unit Spectroscopic Explorer (MUSE) optical integral field spectrograph, following the installation of the 4 Laser Guide Star Facility (4LGSF) on the Unit Telescope 4 (UT4) of the VLT. In this Letter, we delve further into the symbiotic relationship between the 4LGSF laser guide star system, the UT4 telescope, and MUSE by monitoring the spectral contamination of MUSE observations by Raman photons over a 27 month period. This dataset reveals that dust particles deposited on the primary and tertiary mirrors of UT4 -- responsible for a reflectivity loss of ~8% at 6000{\AA} -- contribute (60$\pm5)% to the laser line fluxes detected by MUSE. The flux of Raman lines, contaminating scientific observations acquired with optical spectrographs, thus provides a new, non-invasive means to monitor the evolving scatter properties of the mirrors of astronomical telescopes equipped with laser guide star systems., Comment: 5 pages, 3 figures, 1 table, accepted for publication in A&A Letters

Published
2018
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4. Detection and Implications of Laser-Induced Raman Scattering at Astronomical Observatories

Author

Vogt, F. P. A., Calia, D. Bonaccini, Hackenberg, W., Opitom, C., Comin, M., Schmidtobreik, L., Smoker, J., Blanchard, I., Contreras, M. Espinoza, Aranda, I., Milli, J., Jaffe, Y. L., Selman, F., Kolb, J., Hibon, P., Kuntschner, H., and Madec, P. -Y.

Subjects
Astrophysics - Instrumentation and Methods for Astrophysics, Physics - Atmospheric and Oceanic Physics
Abstract

(Abr.) Laser guide stars employed at astronomical observatories provide artificial wavefront reference sources to help correct (in part) the impact of atmospheric turbulence on astrophysical observations. Following the recent commissioning of the 4 Laser Guide Star Facility (4LGSF) on UT4 at the VLT, we characterize the spectral signature of the uplink beams from the 22W lasers to assess the impact of laser scattering from the 4LGSF on science observations. We use the MUSE optical integral field spectrograph to acquire spectra at a resolution of R~3000 of the uplink laser beams over the wavelength range of 4750\AA\ to 9350\AA. We report the first detection of laser-induced Raman scattering by N2, O2, CO2, H2O and (tentatively) CH4 molecules in the atmosphere above the astronomical observatory of Cerro Paranal. In particular, our observations reveal the characteristic spectral signature of laser photons -- but 480\AA\ to 2210\AA\ redder than the original laser wavelength of 5889.959\AA\ -- landing on the 8.2m primary mirror of UT4 after being Raman-scattered on their way up to the sodium layer. Laser-induced Raman scattering is not unique to the observatory of Cerro Paranal, but common to any astronomical telescope employing a laser-guide-star (LGS) system. It is thus essential for any optical spectrograph coupled to a LGS system to handle thoroughly the possibility of a Raman spectral contamination via a proper baffling of the instrument and suitable calibrations procedures. These considerations are particularly applicable for the HARMONI optical spectrograph on the upcoming Extremely Large Telescope. At sites hosting multiple telescopes, laser collision prediction tools also ought to account for the presence of Raman emission from the uplink laser beam(s) to avoid the unintentional contamination of observations acquired with telescopes in the vicinity of a LGS system., Comment: 17 pages, 11 figures, published in Physical Review X. v2: Fixed typo in Eq. 9 and y-labels in Fig. 6

Published
2017
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5. Different drought‐tolerance strategies of tree species to cope with increased water stress under climate change in a mixed forest.

Author

Aranda, I., Martin‐Benito, D., Sánchez‐Gómez, D., de Simón, B. Fernández, and Gea‐Izquierdo, G.

Subjects
*CLUSTER pine, *MIXED forests, *HOLM oak, *DROUGHT tolerance, *JUNIPERS, *DROUGHTS
Abstract

Trees' functional strategies to cope with extreme drought are essential under climate change. In a mixed Mediterranean forest, we analyzed the functional strategy in response to drought of four co‐occurring species (Pinus pinea, Pinus pinaster, Juniperus oxycedrus, and Quercus ilex) during two years. Specifically, we assessed functional traits related to tree water status, leaf water relations, and gas exchange. Different trait‐syndrome metrics and the functional strategies under water stress observed suggested a species drought‐tolerance differentiation, with the more anysohidric Q. ilex and J. oxycedrus showing a much higher drought tolerance than the more isohydric P. pinea and P. pinaster. All species recovered from negative leaf turgor reached during peak water stress in summer. Q. ilex and J. oxycedrus kept lower leaf osmotic potentials and lower sensitivity of leaf gas exchange and leaf photochemistry to water stress. In contrast, the pine species exhibited more drought‐avoidant and water‐conservative strategies, yet this behavior was less effective in mitigating water stress's impact on their physiology. The pine species were the most affected by drought, with prolonged near‐zero net photosynthesis during summer. P. pinaster was more isohydric than P. pinea and exhibited a lower capacity to maintain leaf turgor. Physiological processes regulating leaf turgor under drought constitute a key functional strategy involved in the carbon and water‐related mechanisms, ultimately inducing mortality under hot drought. The currently observed mortality dynamics for P. pinaster, and to a lower extent in P. pinea, may be exacerbated by loss of functional homeostasis. [ABSTRACT FROM AUTHOR]

Published
2024
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9. PP01.09 Genotypic Characteristics and Resistance Mutations in Advanced ALK+ NSCLC: The ALK-PATHFINDER Study

Author

Castro, R. López, primary, Molla, A. Insa, additional, González, E. Esteban, additional, Rueda, A. Gómez, additional, Casado, D. Isla, additional, Aranda, I. Barneto, additional, Antón, C. Bayona, additional, Tarruella, M. Majem, additional, Muñoz, S. Peralta, additional, Campelo, R. García, additional, Barrera, J. Bosch, additional, Vidal, O. J. Juan, additional, Caro, R. Bernabé, additional, Baz, D. Vicente, additional, Flores, R. Gordo, additional, Mijarra, N. Carrizo, additional, Sánchez, I. Ferrer, additional, López Muñoz, M.E., additional, and Ponce Aix, S., additional

Published
2023
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12. P2.07-02 RET Fusion Testing with FISH and Real-Time PCR: a Comparison with RNA-Based Next-Generation Sequencing in RET Positive NSCLC

Author

Hernandez, S., primary, Rodriguez Carrillo, J.L., additional, Caminoa, A., additional, Benito, A., additional, Martinez, R., additional, Alonso, M., additional, Clave, S., additional, Arriola, E., additional, Esteban-Rodriguez, I., additional, De Castro, J., additional, Sansano, I., additional, Felip, E., additional, Abdulkader, I., additional, Garcia, J., additional, Rojo, F., additional, Domine, M., additional, Teixido, C., additional, Reguart, N., additional, Compañ, D., additional, Insa, A., additional, Mancheño, N., additional, Palanca, S., additional, Juan, O., additional, Baixeras, N., additional, Nadal, E., additional, Cebollero, M., additional, Calles, A., additional, Martin, P., additional, Salas, C., additional, Provencio, M., additional, Aranda, I., additional, Massuti, B., additional, Lopez-Vilaro, L., additional, Majem, M., additional, Garrido, P., additional, Paz-Ares, L., additional, Lopez-Rios, F., additional, and Conde, E., additional

Published
2022
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17. Global transpiration data from sap flow measurements: The SAPFLUXNET database

Author

Ministerio de Ciencia e Innovación (España), Agència de Gestió d'Ajuts Universitaris i de Recerca, Poyatos, R [0000-0003-0521-2523], Granda, V [0000-0002-0469-1991], Flo, V [0000-0003-1908-4577], Adams, MA [0000-0002-8154-0097], Adorjan, B [0000-0002-5482-2515], Aidar, MPM [0000-0001-5728-6749], Alvarado-Barrientos, MS [0000-0003-0098-0806], Anderson-Teixeira, KJ [0000-0001-7585-712X], Arain, MA [0000-0002-1433-5173], Aranda, I [0000-0001-9086-7940], Asbjornsen, H [000-0001-8126-3328], Oishi, AC [0000-0001-5064-4080], Oliveira RS [0000-0002-6392-2526], Oren, R [0000-0002-5654-1733], Ourcival,JM [0000-0002-3557-3496], Paljakka, T [0000-0002-3674-4904], Perez-Priego, O [0000-0002-3138-3177], Peri, PL [0000-0002-5398-4408], Peters, RL [0000-0002-7441-1297], Pfautsch, S [0000-0002-4390-4195], Pockman, WT [0000-0002-3286-0457], Baxter, R [0000-0002-7504-6797], Preisler, Y [0000-0001-5861-8362], Rocha, H [0000-0002-5981-4469], Röll, A [0000-0001-9457-4459], Rosado, BHP [0000-0002-8924-8672], Rowland, L [0000-0002-0774-3216], Rubtsov, A [0000-0002-9663-4344], Sabaté, S [0000-0003-1854-0761], Salmon, Y [0000-0003-4433-4021], Salomón, RL [0000-0003-2674-1731], Sánchez-Costa, E [0000-0001-6799-9611], Beamesderfer, E [0000-0002-7513-7349], Schäfer, K [0000-0001-9452-3619], Schuldt, B [0000-0003-4738-5289], Shashkin, A [0000-0001-9925-5019], Stahl, C [0000-0001-5411-1169], Stojanović, M [0000-0003-4918-8668], Sun, G [0000-0002-0159-1370], Szatniewska, J [0000-0003-3027-9965], Tatarinov, F [0000-0002-8338-6070], Tesar, M [0000-0002-5647-8498], Thomas, FM [0000-0001-6377-719X], Berveiller, D [0000-0001-7461-6420], Tor-ngern, P [0000-0001-7363-4926], Urban, J [0000-0003-1730-947X], Van der Tol, C [0000-0002-2484-8191], Van Meerveld [0000-0002-7547-3270], Varlagin, A [0000-0002-2549-5236], Werner, C [0000-0002-7676-9057], Wieser, G [0000-0002-7575-5657], Wingate, W [0000-0003-1921-1556], Wullschleger, S [0000-0002-9869-0446], Koong, Y [0000-0002-8630-3031], Blakely, B [0000-0001-9923-0794], Zweifel, R [0000-0001-9438-0582], Steppe, K [0000-0001-6252-0704], Mencuccini, M [0000-0003-0840-1477], Martínez-Vilalta, J [0000-0002-2332-7298], Boggs, J [0000-0003-4826-1843], Bohrer, G [0000-0002-9209-9540], Bolstad, P [0000-0002-1829-8859], Bonal, D [0000-0001-9602-8603], Bracho, R [0000-0002-8015-9796], Brodeur, J [0000-0001-7118-8360], Casanoves, F [0000-0001-8765-9382], Chave, J [0000-0002-7766-1347], Chen, H [0000-0001-7619-3425], Cisneros, C [0000-0001-9661-4581], Clark, K [0000-0003-0534-9677], Cremonese, E [0000-0002-6708-8532], Dang, H [0000-0003-4428-3834], David, J [0000-0001-6994-1085], David, T [0000-0003-1473-899X], Delpierre, D [0000-0003-0906-9402], Desai, AR [0000-0002-5226-6041], Do, FC [0000-0002-2852-627X], Dohnal, M [0000-0003-1769-4750], Domec, JC [0000-0003-0478-2559], Dzikiti, S [0000-0002-1892-4143], Edgar, C [0000-0002-7026-8358], Eichstaedt, R [0000-0002-4905-7994], El-Madany, T [0000-0002-0726-7141], Elbers, J [0000-0002-0631-3505], Eller, CB [0000-0002-7795-2574], Euskirchen, E [0000-0002-0848-4295], Ewers, B [0000-0001-6647-7475], Fonti, P [0000-0002-7070-3292], Forner, A [0000-0002-7123-6403], Forrester, D [0000-0003-2732-5692], Freitas, HC [0000-0002-4861-1164], Galvagno, M [0000-0002-0827-487X], Garcia-Tejera, O [0000-0001-7726-8118], Ghimire, CP [0000-0002-3715-6311], Gimeno, TE [0000-0002-1707-9291], Granier, A [0000-0002-4174-2487], Griebel, A [0000-0002-4476-8279], Guangyu, Y [0000-0003-3242-5348], Gush, MB [0000-0003-1328-9862], Hanson, PJ [0000-0001-7293-3561], Hasselquist, N [0000-0003-2777-0163], Heinrich, I [0000-0001-5800-6999], Hernandez-Santana, V [0000-0001-9018-8622], Herrmann, V [0000-0002-4519-481X], Hölttä, T [0000-0001-7677-7156], Holwerda, F [0000-0003-4125-1765], Ayutthaya, SIN [0000-0002-5354-1527], Jochheim,H [0000-0001-8047-4553], Joly, CA [0000-0002-7945-2805], Kim, HS [0000-0002-3440-6071], Klemedtsson, L [0000-0002-1122-0717], Kropp, H [0000-0002-4258-3393], Lagergren, F [0000-0002-0061-733X], Lane, P [0000-0001-6121-8386], Lapenas, A [0000-0002-2135-3636], Lechuga, V [0000-0003-3745-587X], Lee,M [0000-0002-9601-3863], Leuschner, C [0000-0002-5689-7932], Limousin, JM [0000-0002-2734-2495], Linares, JC [0000-0001-8375-6353], Linderson, ML [0000-0001-6578-6671], Lindroth, A [0000-0002-7669-784X], Llorens, P [0000-0003-4591-5303], López-Bernal, A [0000-0002-1034-4718], Loranty, MM[0000-0001-8851-7386], Macinnis-Ng, C [0000-0003-3935-9814], Marechaux, I [0000-0002-5401-0197], Martin, TA [0000-0002-7872-4194], Matheny, A [0000-0002-9532-7131], McDowell, N [0000-0002-2178-2254], Meir, P [0000-0002-2362-0398], Mészáros, I [0000-0001-8841-730X], Migliavacca, M [0000-0003-3546-8407], Mölder, M [0000-0001-6767-3195], Montagnani, L [0000-0003-2957-9071], Moore, GW [0000-0001-5190-5983], Nakada, R [0000-0002-3704-1784], Niu, F [0000-0003-3445-4011], Nolan, R [0000-0001-9277-5142], Norby,R [0000-0002-0238-9828], Novick, K [0000-0002-8431-0879], Oberhuber, W [0000-0002-5197-7044], Obojes, N [0000-0002-6718-2756], Poyatos, R, Granda, V, Flo, V, Adams, MA, Adorján, B, Aguadé, D, Aidar, MPM, Allen, S, Alvarado-Barrientos, MS, Anderson-Teixeira, KJ, Aparecido, LM, Joly, CA, Kaplick, J, Kim, HS, Klemedtsson, L, Kropp, H, Lagergren, F, Lane, P, Lang, P, Lapenas, A, Lechuga, V, Migliavacca, M, Lee, M, Leuschner, C, Limousin, JM, Linares, JC, Linderson, ML, Lindroth, A, Llorens, P, López-Bernal, A, Loranty, MM, Lüttschwager, D, Mitchell, P, MacInnis-Ng, C, Maréchaux, I, Martin, TA, Matheny, A, McDowell, N, McMahon, S, Meir, P, Mészáros, I, Molder, M, Mölder, M, Montagnani, L, Moore, GW, Nakada, R, Niu, F, Nolan, R, Norby,R, Novick, K, Oberhuber, W, Obojes, N, Oishi, AC, Oliveira RS, Oren, R, Ourcival,JM, Paljakka, T, Perez-Priego, O, Peri, PL, Peters, RL, Pfautsch, S, Pockman, WT, Preisler, Y, Rascher, K, Robinson, G, Rocha, H, Rocheteau, A, Röll, A, Rosado, BHP, Rowland, L [, Rubtsov, A, Sabaté, S, Salmon, Y, Salomón, RL, Sánchez-Costa, E, Schäfer, K, Schuldt, B, Shashkin, A, Stahl, C, Stojanovic, M, Suárez, JC, Sun, G, Niu, FR, Szatniewska, J, Tatarinov, F, Tesar, M, Thomas, FM, Tor-ngern, P, Urban, J, Valladares, F, Van der Tol, C, Van Meerveld, Varlagin, A, Norby, R, Voigt, H, Warren, J, Werner, C, Werner, W, Wieser, G, Wingate, W, Wullschleger, S, Koong, Y, Zweifel, R, Arain, MA, Oliveira, RS, Ourcival, JM, Aranda, I, Roll, A, Asbjornsen, H, Baxter, R, Beamesderfer, E, Berry, ZC, Berveiller, D, Blakely, B, Boggs, J, Bohrer, G, Bolstad, PV, Bonal, D, Bracho, R, Brito, P, Brodeur, J, Casanoves, F, Chave, J, Chen, H, Cisneros, C, Clark, K, Cremonese, E, Dang, HZ, David, JS, David, TS, Delpierre, N, Desai, AR, Do, Frederic C., Dohnal, M, Domec, JC, Dzikiti, S, Edgar, C, Eichstaedt, R, El-Madany, TS, Elbers, J, Eller, CB, Euskirchen, ES, Ewers, B, Fonti, P, Forner, A, Forrester, DI, Freitas, HC, Galvagno, M, Garcia-Tejera, O, Ghimire, CP, Gimeno, TE, Grace, J, Granier, A, Griebel, A, Guangyu, Y, Gush, MB, Hanson, PJ, Hasselquist, NJ, Heinrich, I, Hernandez-Santana, V, Herrmann, V, Hölttä, T, Holwerda, F, Irvine, J, Ayutthaya, SIN, Jarvis, PG, Jochheim, H, Ministerio de Ciencia e Innovación (España), Agència de Gestió d'Ajuts Universitaris i de Recerca, Poyatos, R [0000-0003-0521-2523], Granda, V [0000-0002-0469-1991], Flo, V [0000-0003-1908-4577], Adams, MA [0000-0002-8154-0097], Adorjan, B [0000-0002-5482-2515], Aidar, MPM [0000-0001-5728-6749], Alvarado-Barrientos, MS [0000-0003-0098-0806], Anderson-Teixeira, KJ [0000-0001-7585-712X], Arain, MA [0000-0002-1433-5173], Aranda, I [0000-0001-9086-7940], Asbjornsen, H [000-0001-8126-3328], Oishi, AC [0000-0001-5064-4080], Oliveira RS [0000-0002-6392-2526], Oren, R [0000-0002-5654-1733], Ourcival,JM [0000-0002-3557-3496], Paljakka, T [0000-0002-3674-4904], Perez-Priego, O [0000-0002-3138-3177], Peri, PL [0000-0002-5398-4408], Peters, RL [0000-0002-7441-1297], Pfautsch, S [0000-0002-4390-4195], Pockman, WT [0000-0002-3286-0457], Baxter, R [0000-0002-7504-6797], Preisler, Y [0000-0001-5861-8362], Rocha, H [0000-0002-5981-4469], Röll, A [0000-0001-9457-4459], Rosado, BHP [0000-0002-8924-8672], Rowland, L [0000-0002-0774-3216], Rubtsov, A [0000-0002-9663-4344], Sabaté, S [0000-0003-1854-0761], Salmon, Y [0000-0003-4433-4021], Salomón, RL [0000-0003-2674-1731], Sánchez-Costa, E [0000-0001-6799-9611], Beamesderfer, E [0000-0002-7513-7349], Schäfer, K [0000-0001-9452-3619], Schuldt, B [0000-0003-4738-5289], Shashkin, A [0000-0001-9925-5019], Stahl, C [0000-0001-5411-1169], Stojanović, M [0000-0003-4918-8668], Sun, G [0000-0002-0159-1370], Szatniewska, J [0000-0003-3027-9965], Tatarinov, F [0000-0002-8338-6070], Tesar, M [0000-0002-5647-8498], Thomas, FM [0000-0001-6377-719X], Berveiller, D [0000-0001-7461-6420], Tor-ngern, P [0000-0001-7363-4926], Urban, J [0000-0003-1730-947X], Van der Tol, C [0000-0002-2484-8191], Van Meerveld [0000-0002-7547-3270], Varlagin, A [0000-0002-2549-5236], Werner, C [0000-0002-7676-9057], Wieser, G [0000-0002-7575-5657], Wingate, W [0000-0003-1921-1556], Wullschleger, S [0000-0002-9869-0446], Koong, Y [0000-0002-8630-3031], Blakely, B [0000-0001-9923-0794], Zweifel, R [0000-0001-9438-0582], Steppe, K [0000-0001-6252-0704], Mencuccini, M [0000-0003-0840-1477], Martínez-Vilalta, J [0000-0002-2332-7298], Boggs, J [0000-0003-4826-1843], Bohrer, G [0000-0002-9209-9540], Bolstad, P [0000-0002-1829-8859], Bonal, D [0000-0001-9602-8603], Bracho, R [0000-0002-8015-9796], Brodeur, J [0000-0001-7118-8360], Casanoves, F [0000-0001-8765-9382], Chave, J [0000-0002-7766-1347], Chen, H [0000-0001-7619-3425], Cisneros, C [0000-0001-9661-4581], Clark, K [0000-0003-0534-9677], Cremonese, E [0000-0002-6708-8532], Dang, H [0000-0003-4428-3834], David, J [0000-0001-6994-1085], David, T [0000-0003-1473-899X], Delpierre, D [0000-0003-0906-9402], Desai, AR [0000-0002-5226-6041], Do, FC [0000-0002-2852-627X], Dohnal, M [0000-0003-1769-4750], Domec, JC [0000-0003-0478-2559], Dzikiti, S [0000-0002-1892-4143], Edgar, C [0000-0002-7026-8358], Eichstaedt, R [0000-0002-4905-7994], El-Madany, T [0000-0002-0726-7141], Elbers, J [0000-0002-0631-3505], Eller, CB [0000-0002-7795-2574], Euskirchen, E [0000-0002-0848-4295], Ewers, B [0000-0001-6647-7475], Fonti, P [0000-0002-7070-3292], Forner, A [0000-0002-7123-6403], Forrester, D [0000-0003-2732-5692], Freitas, HC [0000-0002-4861-1164], Galvagno, M [0000-0002-0827-487X], Garcia-Tejera, O [0000-0001-7726-8118], Ghimire, CP [0000-0002-3715-6311], Gimeno, TE [0000-0002-1707-9291], Granier, A [0000-0002-4174-2487], Griebel, A [0000-0002-4476-8279], Guangyu, Y [0000-0003-3242-5348], Gush, MB [0000-0003-1328-9862], Hanson, PJ [0000-0001-7293-3561], Hasselquist, N [0000-0003-2777-0163], Heinrich, I [0000-0001-5800-6999], Hernandez-Santana, V [0000-0001-9018-8622], Herrmann, V [0000-0002-4519-481X], Hölttä, T [0000-0001-7677-7156], Holwerda, F [0000-0003-4125-1765], Ayutthaya, SIN [0000-0002-5354-1527], Jochheim,H [0000-0001-8047-4553], Joly, CA [0000-0002-7945-2805], Kim, HS [0000-0002-3440-6071], Klemedtsson, L [0000-0002-1122-0717], Kropp, H [0000-0002-4258-3393], Lagergren, F [0000-0002-0061-733X], Lane, P [0000-0001-6121-8386], Lapenas, A [0000-0002-2135-3636], Lechuga, V [0000-0003-3745-587X], Lee,M [0000-0002-9601-3863], Leuschner, C [0000-0002-5689-7932], Limousin, JM [0000-0002-2734-2495], Linares, JC [0000-0001-8375-6353], Linderson, ML [0000-0001-6578-6671], Lindroth, A [0000-0002-7669-784X], Llorens, P [0000-0003-4591-5303], López-Bernal, A [0000-0002-1034-4718], Loranty, MM[0000-0001-8851-7386], Macinnis-Ng, C [0000-0003-3935-9814], Marechaux, I [0000-0002-5401-0197], Martin, TA [0000-0002-7872-4194], Matheny, A [0000-0002-9532-7131], McDowell, N [0000-0002-2178-2254], Meir, P [0000-0002-2362-0398], Mészáros, I [0000-0001-8841-730X], Migliavacca, M [0000-0003-3546-8407], Mölder, M [0000-0001-6767-3195], Montagnani, L [0000-0003-2957-9071], Moore, GW [0000-0001-5190-5983], Nakada, R [0000-0002-3704-1784], Niu, F [0000-0003-3445-4011], Nolan, R [0000-0001-9277-5142], Norby,R [0000-0002-0238-9828], Novick, K [0000-0002-8431-0879], Oberhuber, W [0000-0002-5197-7044], Obojes, N [0000-0002-6718-2756], Poyatos, R, Granda, V, Flo, V, Adams, MA, Adorján, B, Aguadé, D, Aidar, MPM, Allen, S, Alvarado-Barrientos, MS, Anderson-Teixeira, KJ, Aparecido, LM, Joly, CA, Kaplick, J, Kim, HS, Klemedtsson, L, Kropp, H, Lagergren, F, Lane, P, Lang, P, Lapenas, A, Lechuga, V, Migliavacca, M, Lee, M, Leuschner, C, Limousin, JM, Linares, JC, Linderson, ML, Lindroth, A, Llorens, P, López-Bernal, A, Loranty, MM, Lüttschwager, D, Mitchell, P, MacInnis-Ng, C, Maréchaux, I, Martin, TA, Matheny, A, McDowell, N, McMahon, S, Meir, P, Mészáros, I, Molder, M, Mölder, M, Montagnani, L, Moore, GW, Nakada, R, Niu, F, Nolan, R, Norby,R, Novick, K, Oberhuber, W, Obojes, N, Oishi, AC, Oliveira RS, Oren, R, Ourcival,JM, Paljakka, T, Perez-Priego, O, Peri, PL, Peters, RL, Pfautsch, S, Pockman, WT, Preisler, Y, Rascher, K, Robinson, G, Rocha, H, Rocheteau, A, Röll, A, Rosado, BHP, Rowland, L [, Rubtsov, A, Sabaté, S, Salmon, Y, Salomón, RL, Sánchez-Costa, E, Schäfer, K, Schuldt, B, Shashkin, A, Stahl, C, Stojanovic, M, Suárez, JC, Sun, G, Niu, FR, Szatniewska, J, Tatarinov, F, Tesar, M, Thomas, FM, Tor-ngern, P, Urban, J, Valladares, F, Van der Tol, C, Van Meerveld, Varlagin, A, Norby, R, Voigt, H, Warren, J, Werner, C, Werner, W, Wieser, G, Wingate, W, Wullschleger, S, Koong, Y, Zweifel, R, Arain, MA, Oliveira, RS, Ourcival, JM, Aranda, I, Roll, A, Asbjornsen, H, Baxter, R, Beamesderfer, E, Berry, ZC, Berveiller, D, Blakely, B, Boggs, J, Bohrer, G, Bolstad, PV, Bonal, D, Bracho, R, Brito, P, Brodeur, J, Casanoves, F, Chave, J, Chen, H, Cisneros, C, Clark, K, Cremonese, E, Dang, HZ, David, JS, David, TS, Delpierre, N, Desai, AR, Do, Frederic C., Dohnal, M, Domec, JC, Dzikiti, S, Edgar, C, Eichstaedt, R, El-Madany, TS, Elbers, J, Eller, CB, Euskirchen, ES, Ewers, B, Fonti, P, Forner, A, Forrester, DI, Freitas, HC, Galvagno, M, Garcia-Tejera, O, Ghimire, CP, Gimeno, TE, Grace, J, Granier, A, Griebel, A, Guangyu, Y, Gush, MB, Hanson, PJ, Hasselquist, NJ, Heinrich, I, Hernandez-Santana, V, Herrmann, V, Hölttä, T, Holwerda, F, Irvine, J, Ayutthaya, SIN, Jarvis, PG, and Jochheim, H

Abstract

Plant transpiration links physiological responses of vegetation to water supply and demand with hydrological, energy, and carbon budgets at the land-atmosphere interface. However, despite being the main land evaporative flux at the global scale, transpiration and its response to environmental drivers are currently not well constrained by observations. Here we introduce the first global compilation of whole-plant transpiration data from sap flow measurements (SAPFLUXNET, https://sapfluxnet.creaf.cat/, last access: 8 June 2021). We harmonized and quality-controlled individual datasets supplied by contributors worldwide in a semi-automatic data workflow implemented in the R programming language. Datasets include sub-daily time series of sap flow and hydrometeorological drivers for one or more growing seasons, as well as metadata on the stand characteristics, plant attributes, and technical details of the measurements. SAPFLUXNET contains 202 globally distributed datasets with sap flow time series for 2714 plants, mostly trees, of 174 species. SAPFLUXNET has a broad bioclimatic coverage, with woodland/shrubland and temperate forest biomes especially well represented (80% of the datasets). The measurements cover a wide variety of stand structural characteristics and plant sizes. The datasets encompass the period between 1995 and 2018, with 50% of the datasets being at least 3 years long. Accompanying radiation and vapour pressure deficit data are available for most of the datasets, while on-site soil water content is available for 56% of the datasets. Many datasets contain data for species that make up 90% or more of the total stand basal area, allowing the estimation of stand transpiration in diverse ecological settings. SAPFLUXNET adds to existing plant trait datasets, ecosystem flux networks, and remote sensing products to help increase our understanding of plant water use, plant responses to drought, and ecohydrological processes. SAPFLUXNET version 0.1.5 is freely a

Published
2021

18. Functional phenotypic plasticity mediated by water stress and [CO2] explains differences in drought tolerance of two phylogenetically close conifers.

Author

Férriz, M, Martin-Benito, D, Fernández-de-Simón, M B, Conde, M, García-Cervigón, A I, Aranda, I, and Gea-Izquierdo, G

Subjects
DROUGHTS, DROUGHT tolerance, PHENOTYPIC plasticity, CLUSTER pine, CONIFERS, FOREST dynamics
Abstract

Forests are threatened globally by increased recurrence and intensity of hot droughts. Functionally close coexisting species may exhibit differences in drought vulnerability large enough to cause niche differentiation and affect forest dynamics. The effect of rising atmospheric [CO2], which could partly alleviate the negative effects of drought, may also differ between species. We analysed functional plasticity in seedlings of two taxonomically close pine species (Pinus pinaster Ait. Pinus pinea L.) under different [CO2] and water stress levels. The multidimensional functional trait variability was more influenced by water stress (preferentially xylem traits) and [CO2] (mostly leaf traits) than by differences between species. However, we observed differences between species in the strategies followed to coordinate their hydraulic and structural traits under stress. Leaf 13C discrimination decreased with water stress and increased under elevated [CO2]. Under water stress both species increased their sapwood area to leaf area ratios, tracheid density and xylem cavitation, whereas they reduced tracheid lumen area and xylem conductivity. Pinus pinea was more anisohydric than P. pinaster. Pinus pinaster produced larger conduits under well-watered conditions than P. pinea. Pinus pinea was more tolerant to water stress and more resistant to xylem cavitation under low water potentials. The higher xylem plasticity in P. pinea , particularly in tracheid lumen area, expressed a higher capacity of acclimation to water stress than P. pinaster. In contrast, P. pinaster coped with water stress comparatively more by increasing plasticity of leaf hydraulic traits. Despite the small differences observed in the functional response to water stress and drought tolerance between species, these interspecific differences agreed with ongoing substitution of P. pinaster by P. pinea in forests where both species co-occur. Increased [CO2] had little effect on the species-specific relative performance. Thus, a competitive advantage under moderate water stress of P. pinea compared with P. pinaster is expected to continue in the future. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
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19. Histopathological and virological features of lung, heart and liver percutaneous tissue core biopsy in patients with COVID-19: A clinicopathological case series

Author

Ramos-Rincon JM, Alenda C, García-Sevila R, Silva-Ortega S, García-Navarro M, Vidal I, Ribes I, Portilla J, Cintas A, Moreno-Pérez O, Sánchez-Martínez R, Merino E, and Aranda I

Subjects
postmortem, Aged, 80 and over, SARS-CoV-2, Biopsy, Needle, COVID-19, Pneumonia, Middle Aged, diffuse alveolar damage, Liver, Spain, Pneumonia, Necrotizing, Humans, Lung, Aged
Abstract

INTRODUCTION: Data on pathological changes in COVID-19 are scarce. The aim of this study was to describe the histopathological and virological findings of postmortem biopsies, and the existing clinical correlations, in people who died of COVID-19. MATERIALS AND METHODS: We performed postmortem needle core biopsies of the chest in 11 people who died of COVID-19 pneumonia. Tissue examination was done by light microscopy and real-time polymerase chain reaction (RTPCR). RESULTS: The age of the patients were between 61 to 94 years. Of the 11 postmortem chest biopsies, lung tissue was obtained in 8, myocardium tissue in 7, and liver tissue in 5. Histologically of lung, the main findings pertaining to the lung were diffuse alveolar damage in proliferative phase (n = 4, 50%), diffuse alveolar damage in exudative and proliferative phase (n = 3, 37.5%), diffuse alveolar damage in exudative (n=1; 12.5%) and acute pneumonia (n = 2, 25%). Necrotising pneumonia, acute fibrinous and organising pneumonia, and neutrophils were detected in one sample each (12.5%). Another case presented myocarditis. RT-PCR showed RNA of SARS-CoV-2 in 7 of the 8 lung samples (87.5%), 2 of the 7 myocardial tissue samples (28.6%), and 1 of the 5 liver tissue samples (20%). CONCLUSION: The postmortem examinations show diffuse alveolar damage, as well as acute or necrotising pneumonia. RT-PCR of SARS-CoV-2 was positive in most lung samples.

Published
2022

20. Global transpiration data from sap flow measurements: The SAPFLUXNET database

Author

Poyatos, R, Granda, V, Flo, V, Adams, MA, Adorján, B, Aguadé, D, Aidar, MPM, Allen, S, Alvarado-Barrientos, MS, Anderson-Teixeira, KJ, Aparecido, LM, Joly, CA, Kaplick, J, Kim, HS, Klemedtsson, L, Kropp, H, Lagergren, F, Lane, P, Lang, P, Lapenas, A, Lechuga, V, Migliavacca, M, Lee, M, Leuschner, C, Limousin, JM, Linares, JC, Linderson, ML, Lindroth, A, Llorens, P, López-Bernal, A, Loranty, MM, Lüttschwager, D, Mitchell, P, MacInnis-Ng, C, Maréchaux, I, Martin, TA, Matheny, A, McDowell, N, McMahon, S, Meir, P, Mészáros, I, Molder, M, Mölder, M, Montagnani, L, Moore, GW, Nakada, R, Niu, F, Nolan, R, Norby,R, Novick, K, Oberhuber, W, Obojes, N, Oishi, AC, Oliveira RS, Oren, R, Ourcival,JM, Paljakka, T, Perez-Priego, O, Peri, PL, Peters, RL, Pfautsch, S, Pockman, WT, Preisler, Y, Rascher, K, Robinson, G, Rocha, H, Rocheteau, A, Röll, A, Rosado, BHP, Rowland, L [, Rubtsov, A, Sabaté, S, Salmon, Y, Salomón, RL, Sánchez-Costa, E, Schäfer, K, Schuldt, B, Shashkin, A, Stahl, C, Stojanovic, M, Suárez, JC, Sun, G, Niu, FR, Szatniewska, J, Tatarinov, F, Tesar, M, Thomas, FM, Tor-ngern, P, Urban, J, Valladares, F, Van der Tol, C, Van Meerveld, Varlagin, A, Norby, R, Voigt, H, Warren, J, Werner, C, Werner, W, Wieser, G, Wingate, W, Wullschleger, S, Koong, Y, Zweifel, R, Arain, MA, Oliveira, RS, Ourcival, JM, Aranda, I, Roll, A, Asbjornsen, H, Baxter, R, Beamesderfer, E, Berry, ZC, Berveiller, D, Blakely, B, Boggs, J, Bohrer, G, Bolstad, PV, Bonal, D, Bracho, R, Brito, P, Brodeur, J, Casanoves, F, Chave, J, Chen, H, Cisneros, C, Clark, K, Cremonese, E, Dang, HZ, David, JS, David, TS, Delpierre, N, Desai, AR, Do, Frederic C., Dohnal, M, Domec, JC, Dzikiti, S, Edgar, C, Eichstaedt, R, El-Madany, TS, Elbers, J, Eller, CB, Euskirchen, ES, Ewers, B, Fonti, P, Forner, A, Forrester, DI, Freitas, HC, Galvagno, M, Garcia-Tejera, O, Ghimire, CP, Gimeno, TE, Grace, J, Granier, A, Griebel, A, Guangyu, Y, Gush, MB, Hanson, PJ, Hasselquist, NJ, Heinrich, I, Hernandez-Santana, V, Herrmann, V, Hölttä, T, Holwerda, F, Irvine, J, Ayutthaya, SIN, Jarvis, PG, Jochheim, H, Ministerio de Ciencia e Innovación (España), Agència de Gestió d'Ajuts Universitaris i de Recerca, Poyatos, R [0000-0003-0521-2523], Granda, V [0000-0002-0469-1991], Flo, V [0000-0003-1908-4577], Adams, MA [0000-0002-8154-0097], Adorjan, B [0000-0002-5482-2515], Aidar, MPM [0000-0001-5728-6749], Alvarado-Barrientos, MS [0000-0003-0098-0806], Anderson-Teixeira, KJ [0000-0001-7585-712X], Arain, MA [0000-0002-1433-5173], Aranda, I [0000-0001-9086-7940], Asbjornsen, H [000-0001-8126-3328], Oishi, AC [0000-0001-5064-4080], Oliveira RS [0000-0002-6392-2526], Oren, R [0000-0002-5654-1733], Ourcival,JM [0000-0002-3557-3496], Paljakka, T [0000-0002-3674-4904], Perez-Priego, O [0000-0002-3138-3177], Peri, PL [0000-0002-5398-4408], Peters, RL [0000-0002-7441-1297], Pfautsch, S [0000-0002-4390-4195], Pockman, WT [0000-0002-3286-0457], Baxter, R [0000-0002-7504-6797], Preisler, Y [0000-0001-5861-8362], Rocha, H [0000-0002-5981-4469], Röll, A [0000-0001-9457-4459], Rosado, BHP [0000-0002-8924-8672], Rowland, L [0000-0002-0774-3216], Rubtsov, A [0000-0002-9663-4344], Sabaté, S [0000-0003-1854-0761], Salmon, Y [0000-0003-4433-4021], Salomón, RL [0000-0003-2674-1731], Sánchez-Costa, E [0000-0001-6799-9611], Beamesderfer, E [0000-0002-7513-7349], Schäfer, K [0000-0001-9452-3619], Schuldt, B [0000-0003-4738-5289], Shashkin, A [0000-0001-9925-5019], Stahl, C [0000-0001-5411-1169], Stojanović, M [0000-0003-4918-8668], Sun, G [0000-0002-0159-1370], Szatniewska, J [0000-0003-3027-9965], Tatarinov, F [0000-0002-8338-6070], Tesar, M [0000-0002-5647-8498], Thomas, FM [0000-0001-6377-719X], Berveiller, D [0000-0001-7461-6420], Tor-ngern, P [0000-0001-7363-4926], Urban, J [0000-0003-1730-947X], Van der Tol, C [0000-0002-2484-8191], Van Meerveld [0000-0002-7547-3270], Varlagin, A [0000-0002-2549-5236], Werner, C [0000-0002-7676-9057], Wieser, G [0000-0002-7575-5657], Wingate, W [0000-0003-1921-1556], Wullschleger, S [0000-0002-9869-0446], Koong, Y [0000-0002-8630-3031], Blakely, B [0000-0001-9923-0794], Zweifel, R [0000-0001-9438-0582], Steppe, K [0000-0001-6252-0704], Mencuccini, M [0000-0003-0840-1477], Martínez-Vilalta, J [0000-0002-2332-7298], Boggs, J [0000-0003-4826-1843], Bohrer, G [0000-0002-9209-9540], Bolstad, P [0000-0002-1829-8859], Bonal, D [0000-0001-9602-8603], Bracho, R [0000-0002-8015-9796], Brodeur, J [0000-0001-7118-8360], Casanoves, F [0000-0001-8765-9382], Chave, J [0000-0002-7766-1347], Chen, H [0000-0001-7619-3425], Cisneros, C [0000-0001-9661-4581], Clark, K [0000-0003-0534-9677], Cremonese, E [0000-0002-6708-8532], Dang, H [0000-0003-4428-3834], David, J [0000-0001-6994-1085], David, T [0000-0003-1473-899X], Delpierre, D [0000-0003-0906-9402], Desai, AR [0000-0002-5226-6041], Do, FC [0000-0002-2852-627X], Dohnal, M [0000-0003-1769-4750], Domec, JC [0000-0003-0478-2559], Dzikiti, S [0000-0002-1892-4143], Edgar, C [0000-0002-7026-8358], Eichstaedt, R [0000-0002-4905-7994], El-Madany, T [0000-0002-0726-7141], Elbers, J [0000-0002-0631-3505], Eller, CB [0000-0002-7795-2574], Euskirchen, E [0000-0002-0848-4295], Ewers, B [0000-0001-6647-7475], Fonti, P [0000-0002-7070-3292], Forner, A [0000-0002-7123-6403], Forrester, D [0000-0003-2732-5692], Freitas, HC [0000-0002-4861-1164], Galvagno, M [0000-0002-0827-487X], Garcia-Tejera, O [0000-0001-7726-8118], Ghimire, CP [0000-0002-3715-6311], Gimeno, TE [0000-0002-1707-9291], Granier, A [0000-0002-4174-2487], Griebel, A [0000-0002-4476-8279], Guangyu, Y [0000-0003-3242-5348], Gush, MB [0000-0003-1328-9862], Hanson, PJ [0000-0001-7293-3561], Hasselquist, N [0000-0003-2777-0163], Heinrich, I [0000-0001-5800-6999], Hernandez-Santana, V [0000-0001-9018-8622], Herrmann, V [0000-0002-4519-481X], Hölttä, T [0000-0001-7677-7156], Holwerda, F [0000-0003-4125-1765], Ayutthaya, SIN [0000-0002-5354-1527], Jochheim,H [0000-0001-8047-4553], Joly, CA [0000-0002-7945-2805], Kim, HS [0000-0002-3440-6071], Klemedtsson, L [0000-0002-1122-0717], Kropp, H [0000-0002-4258-3393], Lagergren, F [0000-0002-0061-733X], Lane, P [0000-0001-6121-8386], Lapenas, A [0000-0002-2135-3636], Lechuga, V [0000-0003-3745-587X], Lee,M [0000-0002-9601-3863], Leuschner, C [0000-0002-5689-7932], Limousin, JM [0000-0002-2734-2495], Linares, JC [0000-0001-8375-6353], Linderson, ML [0000-0001-6578-6671], Lindroth, A [0000-0002-7669-784X], Llorens, P [0000-0003-4591-5303], López-Bernal, A [0000-0002-1034-4718], Loranty, MM[0000-0001-8851-7386], Macinnis-Ng, C [0000-0003-3935-9814], Marechaux, I [0000-0002-5401-0197], Martin, TA [0000-0002-7872-4194], Matheny, A [0000-0002-9532-7131], McDowell, N [0000-0002-2178-2254], Meir, P [0000-0002-2362-0398], Mészáros, I [0000-0001-8841-730X], Migliavacca, M [0000-0003-3546-8407], Mölder, M [0000-0001-6767-3195], Montagnani, L [0000-0003-2957-9071], Moore, GW [0000-0001-5190-5983], Nakada, R [0000-0002-3704-1784], Niu, F [0000-0003-3445-4011], Nolan, R [0000-0001-9277-5142], Norby,R [0000-0002-0238-9828], Novick, K [0000-0002-8431-0879], Oberhuber, W [0000-0002-5197-7044], and Obojes, N [0000-0002-6718-2756]

Subjects
Stomatal condua, Sapflow measurements, Heat-pulse method, Vapor- pressure deficit, Radial patterns, Water use strategies, Eddy covariance, Fluw density, Thermal dissipation
Abstract

Plant transpiration links physiological responses of vegetation to water supply and demand with hydrological, energy, and carbon budgets at the land-atmosphere interface. However, despite being the main land evaporative flux at the global scale, transpiration and its response to environmental drivers are currently not well constrained by observations. Here we introduce the first global compilation of whole-plant transpiration data from sap flow measurements (SAPFLUXNET, https://sapfluxnet.creaf.cat/, last access: 8 June 2021). We harmonized and quality-controlled individual datasets supplied by contributors worldwide in a semi-automatic data workflow implemented in the R programming language. Datasets include sub-daily time series of sap flow and hydrometeorological drivers for one or more growing seasons, as well as metadata on the stand characteristics, plant attributes, and technical details of the measurements. SAPFLUXNET contains 202 globally distributed datasets with sap flow time series for 2714 plants, mostly trees, of 174 species. SAPFLUXNET has a broad bioclimatic coverage, with woodland/shrubland and temperate forest biomes especially well represented (80% of the datasets). The measurements cover a wide variety of stand structural characteristics and plant sizes. The datasets encompass the period between 1995 and 2018, with 50% of the datasets being at least 3 years long. Accompanying radiation and vapour pressure deficit data are available for most of the datasets, while on-site soil water content is available for 56% of the datasets. Many datasets contain data for species that make up 90% or more of the total stand basal area, allowing the estimation of stand transpiration in diverse ecological settings. SAPFLUXNET adds to existing plant trait datasets, ecosystem flux networks, and remote sensing products to help increase our understanding of plant water use, plant responses to drought, and ecohydrological processes. SAPFLUXNET version 0.1.5 is freely available from the Zenodo repository (10.5281/zenodo.3971689; Poyatos et al., 2020a). The "sapfluxnetr"R package-designed to access, visualize, and process SAPFLUXNET data-is available from CRAN. This research was supported by the Ministerio de Economía y Competitividad (grant no. CGL2014-55883-JIN), the Ministerio de Ciencia e Innovación (grant no. RTI2018-095297-J-I00), the Ministerio de Ciencia e Innovación (grant no. CAS16/00207), the Agència de Gestió d'Ajuts Universitaris i de Recerca (grant no. SGR1001), the Alexander von Humboldt-Stiftung (Humboldt Research Fellowship for Experienced Researchers (RP)), and the Institució Catalana de Recerca i Estudis Avançats (Academia Award (JMV)). Víctor Flo was supported by the doctoral fellowship FPU15/03939 (MECD, Spain).

Published
2021

21. RES4LL

Author

Apóstoles, A., Aranda, I., Da Costa, G., and Ortega, A.

Subjects
Resina epoxi, Catalizador, Viscosidad
Abstract

Nuestro proyecto ha consistido en mezclar resina epoxi junto con un catalizador y un espesante alimenticio. El objetivo era conseguir un material menos perjudicial y más barato que la mezcla entre la resina epoxi y algunos aditivos. El resultado obtenido es un material con bastante resistencia, impermeable, flexible en láminas pequeñas, aparte de ser muy buen pegamento. Esta mezcla dadas las características que tiene puede poseer diferentes funciones dependiendo de la cantidad de espesante usado ya que este varía notablemente sus propiedades, pasando de un pegamento a una masilla utilizable en baños como junta de baldosas o azulejos.

Published
2021

26. MA14.02 RET Fusion Testing in Advanced Non-Small Cell Lung Carcinoma Patients: the RETING Study

Author

Conde, E., primary, Hernandez, S., additional, Caminoa, A., additional, Benito, A., additional, Martinez, R., additional, Alonso, M., additional, Jimenez, B., additional, Boni, V., additional, Remon, J., additional, Pijuan, L., additional, Clave, S., additional, Arriola, E., additional, Esteban, I., additional, De Castro, J., additional, Sansano, I., additional, Felip, E., additional, Abdulkader, I., additional, Garcia, J., additional, Rojo, F., additional, Domine, M., additional, Teixido, C., additional, Reguart, N., additional, Compañ, D., additional, Insa, A., additional, Mancheño, N., additional, Palanca, S., additional, Juan, O., additional, Baixeras, N., additional, Nadal, E., additional, Cebollero, M., additional, Calles, A., additional, Martin, P., additional, Salas, C., additional, Provencio, M., additional, Aranda, I., additional, Massuti, B., additional, Lopez-Vilaro, L., additional, Majem, M., additional, Enguita, A.B., additional, Paz-Ares, L., additional, Garrido, P., additional, and Lopez-Rios, F., additional

Published
2021
Full Text
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33. Pre-treatment tissue TCR repertoire evenness is associated with complete pathological response in patients with NSCLC receiving neoadjuvant chemoimmunotherapy

Author

Casarrubios M, Cruz-Bermudez A, Nadal E, Insa A, Garcia-Campelo R, Lazaro M, Domine M, Majem M, Rodriguez-Abreu D, Martinez-Marti A, de Castro-Carpeno J, Cobo M, Lopez-Vivanco G, Del Barco E, Bernabe Caro R, Vinolas N, Barneto Aranda I, Viteri S, Massuti B, Barquin M, Laza-Briviesca R, Sierra-Rodero B, Parra E, Sanchez-Espiridion B, Rocha P, Kadara H, Wistuba I, Romero A, Calvo V, and Provencio M

Abstract

PURPOSE: Characterization of the T-cell receptor (TCR) repertoire may be a promising source for predictive biomarkers of pathological response to immunotherapy in locally-advanced non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN: In this study, next-generation TCR sequencing was performed in peripheral blood and tissue samples of 40 NSCLC patients, before and after neoadjuvant chemoimmunotherapy (NADIM clinical trial, NCT03081689), considering their complete pathologic response (CPR) or non-CPR. Beyond TCR metrics, tissue clones were ranked by their frequency and spatiotemporal evolution of top 1% clones was determined. RESULTS: We have found a positive association between an uneven TCR repertoire in tissue samples at diagnosis and CPR at surgery. Moreover, TCR most frequent-ranked clones (top 1%) present in diagnostic biopsies occupied greater frequency in the total clonal space of CPR patients, achieving an AUC ROC to identify CPR patients of 0.967 (95% CI, 0.897 to 1.000; p=0.001), and improving the results of PD-L1 TPS (AUC 0.767; p=0.026) or TMB (AUC 0.550; p=0.687). Furthermore, tumors with high pre-treatment top 1% clonal space showed similar immune cell populations but a higher immune reactive gene expression profile. Finally, the selective expansion of pre-treatment tissue top 1% clones in peripheral blood of CPR patients suggests also a peripheral immunosurveillance, which could explain the high survival rate of these patients. CONCLUSIONS: We have identified two parameters derived from TCR repertoire analysis that could outperform PD-L1 TPS and TMB as predictive biomarkers of CPR after neoadjuvant chemoimmunotherapy, and unraveled possible mechanisms of CPR involving enhanced tumor immunogenicity and peripheral immunosurveillance.

Published
2021

34. Global transpiration data from sap flow measurements: The SAPFLUXNET database

Author

Poyatos, R., Granda, V, Flo, V., Adorján, B., Adams, M. A., Aguadé, D., Aidar, M. P. M., Allen, S., Alvarado-Barrientos, M. S., Anderson-Teixeira, K. J., Aparecido, L. M., Altaf Arain, M., Aranda, I., Asbjornsen, H., Baxter, R., Beamesderfer, E., Berry, Z. C., Berveiller, D., Blakely, B., Boggs, J., Bohrer, G., Bolstad, P. V., Bonal, D., Bracho, R., Brito, P., Brodeur, J., Casanoves, F., Chave, J., Chen, H., Cisneros, C., Clark, K., Cremonese, E., Dang, H., David, J. S., David, T. S., Delpierre, N., Desai, A. R., Do, F. C., Dohnal, N., Domec, J. C., Dzikiti, S., Edgar, C., Eichstaedt, R., El-Madany, T. S., Elbers, J., Eller, C. B., Euskirchen, E. S., Ewers, B., Fonti, P., Forner, A., Forrester, D. I., Freitas, H. C., Galvagno, M., Garcia-Tejera, O., Ghimire, C. P., Gimeno, T. E., Grace, J., Granier, A., Griebel, A., Guangyu, Y., Gush, M. B., Hanson, P. J., Hasselquist, N. J., Heinrich, I., Hernandez-Santana, V., Herrmann, V, Hölttä, T., Holwerda, F., Irvine, J., Na Ayutthaya, S. Y., Jarvis, P. J., Jochheim, H., Joly, C. A., Kaplick, J., Kim, H. S., Klemedtsson, L., Kropp, H., Lagergren, F., Lane, P., Lang, P., Lapenas, A., Lechuga, V., Lee, M., Leuschner, C., Limousin, J. M., Linares, J. C., Linderson, M. L., Lindroth, A., Llorens, P., López-Bernal, A., Loranty, M. M., Lüttschwager, D., MacInnis-Ng, C., Maréchaux, I., Martin, T. A., Matheny, A., McDowell, N., McMahon, S., Meir, P., Mészáros, I., Migliavacca, M., Mitchell, P., Mölder, M., Montagnani, L., Moore, G. W., Nakada, R., Niu, F., Nolan, R.H., Norby, R., Novick, K., Oberhuber, W., Obojes, N., Oishi, A. C., Oliveira, R. S., Olen, R., Ourcival, J. M., Paljakka, T., Perez Priego, O., Peri, P. L., Peters, R. L., Pfautsch, S., Pockman, W. T., Preysler, I., Rascher, K., Robinson, G., Rocheteau, A., Rocha, H., Röll, A., Rosado, B. H. P., Rowland, L., Rubtsov, A. V., Sabaté, S., Salmón, Y., Salomon, R. L., Schäfer, K. V. R., Sánchez-Costa, E., Schuld, B., Shashkin, A., Stahl, C., Stojanovic, M., Suárez, J. C., Szatniewska, J, Sun, G., Tatarinov, F., TesaÅ, M, Thomas, F. M., Tor-Ngern, P., Urban, J., Valladares, F., Van Der Tol, C., Van Meerveld, I., Varlagin, A., Voigt, H., Warren, J., Werner, C., Poyatos, R., Granda, V, Flo, V., Adorján, B., Adams, M. A., Aguadé, D., Aidar, M. P. M., Allen, S., Alvarado-Barrientos, M. S., Anderson-Teixeira, K. J., Aparecido, L. M., Altaf Arain, M., Aranda, I., Asbjornsen, H., Baxter, R., Beamesderfer, E., Berry, Z. C., Berveiller, D., Blakely, B., Boggs, J., Bohrer, G., Bolstad, P. V., Bonal, D., Bracho, R., Brito, P., Brodeur, J., Casanoves, F., Chave, J., Chen, H., Cisneros, C., Clark, K., Cremonese, E., Dang, H., David, J. S., David, T. S., Delpierre, N., Desai, A. R., Do, F. C., Dohnal, N., Domec, J. C., Dzikiti, S., Edgar, C., Eichstaedt, R., El-Madany, T. S., Elbers, J., Eller, C. B., Euskirchen, E. S., Ewers, B., Fonti, P., Forner, A., Forrester, D. I., Freitas, H. C., Galvagno, M., Garcia-Tejera, O., Ghimire, C. P., Gimeno, T. E., Grace, J., Granier, A., Griebel, A., Guangyu, Y., Gush, M. B., Hanson, P. J., Hasselquist, N. J., Heinrich, I., Hernandez-Santana, V., Herrmann, V, Hölttä, T., Holwerda, F., Irvine, J., Na Ayutthaya, S. Y., Jarvis, P. J., Jochheim, H., Joly, C. A., Kaplick, J., Kim, H. S., Klemedtsson, L., Kropp, H., Lagergren, F., Lane, P., Lang, P., Lapenas, A., Lechuga, V., Lee, M., Leuschner, C., Limousin, J. M., Linares, J. C., Linderson, M. L., Lindroth, A., Llorens, P., López-Bernal, A., Loranty, M. M., Lüttschwager, D., MacInnis-Ng, C., Maréchaux, I., Martin, T. A., Matheny, A., McDowell, N., McMahon, S., Meir, P., Mészáros, I., Migliavacca, M., Mitchell, P., Mölder, M., Montagnani, L., Moore, G. W., Nakada, R., Niu, F., Nolan, R.H., Norby, R., Novick, K., Oberhuber, W., Obojes, N., Oishi, A. C., Oliveira, R. S., Olen, R., Ourcival, J. M., Paljakka, T., Perez Priego, O., Peri, P. L., Peters, R. L., Pfautsch, S., Pockman, W. T., Preysler, I., Rascher, K., Robinson, G., Rocheteau, A., Rocha, H., Röll, A., Rosado, B. H. P., Rowland, L., Rubtsov, A. V., Sabaté, S., Salmón, Y., Salomon, R. L., Schäfer, K. V. R., Sánchez-Costa, E., Schuld, B., Shashkin, A., Stahl, C., Stojanovic, M., Suárez, J. C., Szatniewska, J, Sun, G., Tatarinov, F., TesaÅ, M, Thomas, F. M., Tor-Ngern, P., Urban, J., Valladares, F., Van Der Tol, C., Van Meerveld, I., Varlagin, A., Voigt, H., Warren, J., and Werner, C.

Abstract

Plant transpiration links physiological responses of vegetation to water supply and demand with hydrological, energy, and carbon budgets at the land-atmosphere interface. However, despite being the main land evaporative flux at the global scale, transpiration and its response to environmental drivers are currently not well constrained by observations. Here we introduce the first global compilation of whole-plant transpiration data from sap flow measurements (SAPFLUXNET, https://sapfluxnet.creaf.cat/, last access: 8 June 2021). We harmonized and quality-controlled individual datasets supplied by contributors worldwide in a semi-automatic data workflow implemented in the R programming language. Datasets include sub-daily time series of sap flow and hydrometeorological drivers for one or more growing seasons, as well as metadata on the stand characteristics, plant attributes, and technical details of the measurements. SAPFLUXNET contains 202 globally distributed datasets with sap flow time series for 2714 plants, mostly trees, of 174 species. SAPFLUXNET has a broad bioclimatic coverage, with woodland/shrubland and temperate forest biomes especially well represented (80% of the datasets). The measurements cover a wide variety of stand structural characteristics and plant sizes. The datasets encompass the period between 1995 and 2018, with 50% of the datasets being at least 3 years long. Accompanying radiation and vapour pressure deficit data are available for most of the datasets, while on-site soil water content is available for 56% of the datasets. Many datasets contain data for species that make up 90% or more of the total stand basal area, allowing the estimation of stand transpiration in diverse ecological settings. SAPFLUXNET adds to existing plant trait datasets, ecosystem flux networks, and remote sensing products to help increase our understanding of plant water use, plant responses to drought, and ecohydrological processes. SAPFLUXNET version 0.1.5 is freely a

Published
2021

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