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766 results on '"Araki Atsuko"'

9. Impact of prenatal exposure to mercury and selenium on neurodevelopmental delay in children in the Japan environment and Children’s study using the ASQ-3 questionnaire: A prospective birth cohort

Author

Kobayashi, Sumitaka, Itoh, Sachiko, Miyashita, Chihiro, Ait Bamai, Yu, Yamaguchi, Takeshi, Masuda, Hideyuki, Itoh, Mariko, Yamazaki, Keiko, Tamura, Naomi, Hanley, Sharon J.B., Ikeda-Araki, Atsuko, Saijo, Yasuaki, Ito, Yoshiya, Iwai-Shimada, Miyuki, Yamazaki, Shin, Kamijima, Michihiro, and Kishi, Reiko

Published
2022
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13. Determination of plasma lysophosphatidylethanolamines (lyso-PE) by LC-MS/MS revealed a possible relation between obesity and lyso-PE in Japanese preadolescent children: The Hokkaido study.

Author

Inoue, Nao, Gowda, Siddabasave Gowda B., Gowda, Divyavani, Sakurai, Toshihiro, Ikeda-Araki, Atsuko, Bamai, Yu Ait, Ketema, Rahel Mesfin, Kishi, Reiko, Chiba, Hitoshi, and Hui, Shu-Ping

Subjects
LIQUID chromatography-mass spectrometry, INDUCTIVELY coupled plasma mass spectrometry, OVERWEIGHT children, CHILDHOOD obesity, COLLISION induced dissociation, LIQUID chromatography
Abstract

Background: Lysophosphatidylethanolamines (lyso-PEs) are the partial hydrolysis products of phosphatidylethanolamine. Although lyso-PEs are important biomarkers in various diseases, their determination is limited by the lack of simple and efficient quantification methods. This study aims to develop an improved quantitative method for the determination of lyso-PEs and its application to an epidemiological study. Methods: Single reaction monitoring channels by collision-induced dissociation for seven lyso-PEs were established using liquid chromatography-tandem mass spectrometry. Plasma lyso-PEs were extracted with a single-phase method using an isotopically labelled internal standard for quantification. The proposed method was adopted to define lyso-PEs in plasma samples of children aged 9–12 years living in Sapporo, Japan. Results: The limit of detection and limit of quantification for each lyso-PE ranged between 0.001–0.015 and 0.002–0.031 pmol/ μ L, respectively. Recoveries were found to be > 91% for all the species. The analysis results of children's plasma showed that the total lyso-PE concentrations in boys (n = 181) and girls (n = 161) were 11.53 and 11.00 pmol/ μ L (median), respectively. Participants were further classified by the percentage of overweight and subgrouped as underweight (n = 12), normal range (n = 292), or overweight (n = 38). Interestingly, the reduction of lyso-PE 16:0 and increased lyso-PE 22:6 were observed in overweight children compared with normal range (Fold change: 0.909 and 1.174, respectively). Conclusions: This study successfully established a simple quantitative method to determine lyso-PE concentrations. Furthermore, our method revealed the possible relation between plasma lyso-PEs and overweight status. [ABSTRACT FROM AUTHOR]

Published
2025
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14. Association of exposure to prenatal perfluoroalkyl substances and estrogen receptor 1 polymorphisms with the second to fourth digit ratio in school-aged children: The Hokkaido study

Author

Nishimura, Yoko, Moriya, Kimihiko, Kobayashi, Sumitaka, Ikeda- Araki, Atsuko, Sata, Fumihiro, Mitsui, Takahiko, Itoh, Sachiko, Miyashita, Chihiro, Cho, Kazutoshi, Kon, Masafumi, Nakamura, Michiko, Kitta, Takeya, Murai, Sachiyo, Kishi, Reiko, and Shinohara, Nobuo

Published
2022
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17. The association between prenatal perfluoroalkyl substance exposure and symptoms of attention-deficit/hyperactivity disorder in 8-year-old children and the mediating role of thyroid hormones in the Hokkaido study

Author

Itoh, Sachiko, Yamazaki, Keiko, Suyama, Satoshi, Ikeda-Araki, Atsuko, Miyashita, Chihiro, Ait Bamai, Yu, Kobayashi, Sumitaka, Masuda, Hideyuki, Yamaguchi, Takeshi, Goudarzi, Houman, Okada, Emiko, Kashino, Ikuko, Saito, Takuya, and Kishi, Reiko

Published
2022
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36. Mediating Factors Between Parental Socioeconomic Status and Small for Gestational Age in Infants: Results from the Hokkaido Study on Environment and Children's Health

Author

Tamura, Naomi, Hanaoka, Tomoyuki, Ito, Kumiko, Araki, Atsuko, Miyashita, Chihiro, Ito, Sachiko, and Kobayashi, Sumitaka

Subjects
Health aspects, Drinking in pregnancy -- Health aspects, Smoking in pregnancy -- Health aspects, Gestational age -- Health aspects, Body mass index -- Health aspects, Prenatal influences -- Health aspects, Social class -- Health aspects, Social classes -- Health aspects
Abstract

Author(s): Naomi Tamura [sup.1] [sup.2] [sup.3] , Tomoyuki Hanaoka [sup.1] , Kumiko Ito [sup.1] [sup.4] , Atsuko Araki [sup.1] [sup.2] , Chihiro Miyashita [sup.1] , Sachiko Ito [sup.1] , Sumitaka [...], Objectives Previous studies indicated a significant association between small for gestational age (SGA) in infants and their parents' socioeconomic status (SES). Thus, this study aimed to examine if parental factors, such as maternal smoking, and the pre-pregnancy body mass index (BMI) could mediate the associations between parental SES and SGA. Methods The participants of this study were pregnant women who enrolled in an ongoing birth cohort study, the Hokkaido study, during the first trimester of their pregnancies. A total of 14,593 live singleton births were included in the statistical analysis, of which 1011 (6.9%) were SGA. Two structural equation models were employed to evaluate the associations between parental SES, parental characteristics, and SGA. Results The effect of low SES on SGA was directly mediated by maternal pre-pregnancy BMI, smoking during the third trimester, and alcohol consumption during the first trimester in the first model, which was based the assumption of independent associations between mediating factors. In the second model, which additionally considered the mediating factors from the first model, smoking during pregnancy mediated decline in parental SES, consequently increased SGA. Moreover, an increase in pregnancy smoking status increased the prevalence of lower maternal pre-pregnancy BMI and its effect on SGA. Conclusions for Practice In this study, we observed the independent mediating effect of maternal pre-pregnancy BMI, smoking, and alcohol consumption during pregnancy on low SES and, consequently, SGA, with the additional mediating pathway of SES to smoking to low BMI on SGA.

Published
2021
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38. Association of exposure to prenatal phthalate esters and bisphenol A and polymorphisms in the ESR1 gene with the second to fourth digit ratio in school-aged children: Data from the Hokkaido study

Author

Nishimura, Yoko, Moriya, Kimihiko, Kobayashi, Sumitaka, Araki, Atsuko, Sata, Fumihiro, Mitsui, Takahiko, Itoh, Sachiko, Miyashita, Chihiro, Cho, Kazutoshi, Kon, Masafumi, Nakamura, Michiko, Kitta, Takeya, Murai, Sachiyo, Kishi, Reiko, and Shinohara, Nobuo

Published
2020
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39. Factors correlating with serum birch pollen IgE status in pregnant women in Hokkaido, Japan: The Japan Environment and Children's Study (JECS)

Author

Kamijima, Michihiro, Yamazaki, Shin, Ohya, Yukihiro, Kishi, Reiko, Yaegashi, Nobuo, Hashimoto, Koichi, Mori, Chisato, Ito, Shuichi, Yamagata, Zentaro, Inadera, Hidekuni, Nakayama, Takeo, Iso, Hiroyasu, Shima, Masayuki, Kurozawa, Youichi, Suganuma, Narufumi, Kusuhara, Koichi, Katoh, Takahiko, Saijo, Yasuaki, Yoshioka, Eiji, Sato, Yukihiro, Miyamoto, Toshinobu, Sengoku, Kazuo, Ito, Yoshiya, Itoh, Sachiko, Miyashita, Chihiro, and Araki, Atsuko

Published
2020
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