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20 results on '"Arakelian, Lousineh"'

3. Development and qualification of clinical grade decellularized and cryopreserved human esophagi

Author

Godefroy, William, Faivre, Lionel, Sansac, Caroline, Thierry, Briac, Allain, Jean-Marc, Bruneval, Patrick, Agniel, Rémy, Kellouche, Sabrina, Monasson, Olivier, Peroni, Elisa, Jarraya, Mohamed, Setterblad, Niclas, Braik, Massymissa, Even, Benjamin, Cheverry, Sophie, Domet, Thomas, Albanese, Patricia, Larghero, Jérôme, Cattan, Pierre, and Arakelian, Lousineh

Published
2023
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6. Esophagus Decellularization

Author

Arakelian, Lousineh, Godefroy, William, Faivre, Lionel, Cattan, Pierre, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Kajbafzadeh, Abdol-Mohammad, editor

Published
2021
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8. Full circumferential human tracheal replacement: a systematic review.

Author

Thierry, Briac, Arakelian, Lousineh, Denoyelle, Françoise, Larghero, Jérôme, and Wurtz, Alain

Subjects
*PLASTIC surgery, *SURGICAL indications, *OPERATIVE surgery, *THORACIC surgery, *GRANULATION
Abstract

Full Circumferential Tracheal Replacement (FCTR) is a surgical challenge, indicated in rare cases of extensive tracheal resection, with no consensus on surgical technique or materials. A systematic review according to PRISMA guidelines was carried out from 2000 to 2022 to identify cases of FCTR, to compare surgical indications, the nature of the tracheal substitutes and their immunological characteristics, surgical replacement techniques and vascularization. Thirty-seven patients, including five children, underwent FCTR surgery using 4 different techniques: thyrotracheal complex allograft (n  = 2), aorta (n  = 12), autologous surgical reconstruction (n  = 19), tissue-engineered decellularized trachea (n  = 4). The mean follow-up was 4 years. Of the 15 deceased patients, 10 died of the progression of the initial pathology. For the majority of the teams, particular care was given to the vascularization of the substitute, in order to guarantee long-term biointegration. This included either direct vascularization via vascular anastomosis, or an indirect technique involving envelopment of the avascular substitute in a richly vascularized tissue. Stent placement was standard, except for autologous surgical reconstructions where tracheal caliber was stable. Internal stents were frequently complicated by granulation and stenosis. Although epithelial coverage is essential to limit endoluminal proliferation and act as a barrier, fully functional ciliated airway epithelium did not seem to be necessary. In order to facilitate future comparisons, a standardized clinical trial, respecting regulatory constraints, including routine follow-up with tracheal biomechanics assessment and scheduled biopsies could be proposed. It would help collecting information such as dynamics and mechanisms of tracheal bio-integration and regeneration. [ABSTRACT FROM AUTHOR]

Published
2024
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13. Culture of hepatic and stem cell spheroids in acoustic levitation induces different self-organisation dynamics

Author

Rabiet, Lucile, Rojas Garcia, Duvan, Arakelian, Lousineh, Hoyos, Mauricio, Jeger-Madiot, Nathan, Larghero, Jerome, Aider, Jean-Luc, and AIDER, Jean-Luc

Subjects
[SPI.ACOU] Engineering Sciences [physics]/Acoustics [physics.class-ph], [PHYS.PHYS.PHYS-BIO-PH] Physics [physics]/Physics [physics]/Biological Physics [physics.bio-ph], [SDV.BC] Life Sciences [q-bio]/Cellular Biology, [SDV.BIO] Life Sciences [q-bio]/Biotechnology
Published
2022

14. Self-organization of human mesenchymal stem cells into spheroids trapped in acoustic levitation

Author

Jeger-Madiot, Nathan, Arakelian, Lousineh, Setterblad, Niclas, Bruneval, Patrick, Hoyos, Mauricio, Larghero, Jérôme, Aider, Jean-Luc, Physique et mécanique des milieux hétérogenes (UMR 7636) (PMMH), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Hopital Saint-Louis [AP-HP] (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine, ex- Institut Universitaire Hématologie-IUH) (IRSL), Université de Paris (UP), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Immunologie humaine, physiopathologie & immunothérapie (HIPI (UMR_S_976 / U976)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université Paris Cité (UPCité), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), and AIDER, Jean-Luc

Subjects
[SDV.BC]Life Sciences [q-bio]/Cellular Biology, [PHYS.MECA.ACOU] Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph], [SDV.BC] Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS, [PHYS.MECA.ACOU]Physics [physics]/Mechanics [physics]/Acoustics [physics.class-ph]
Abstract

International audience

Published
2021

15. Fabrication of 2D monolayers and 3D spheroids of cells in acoustic levitation

Author

Jeger-Madiot, Nathan, Setterblad, Niclas, Arakelian, Lousineh, Vanneaux, Valérie, Hoyos, Mauricio, Larghero, Jérôme, Aider, Jean-Luc, Physique et mécanique des milieux hétérogenes (UMR 7636) (PMMH), Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Institut de Recherche Saint-Louis - Hématologie Immunologie Oncologie (Département de recherche de l’UFR de médecine, ex- Institut Universitaire Hématologie-IUH) (IRSL), Université de Paris (UP), Unité de thérapie cellulaire et CIC de biothérapies, Hopital Saint-Louis [AP-HP] (AP-HP), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

Subjects
[SDV.BIO]Life Sciences [q-bio]/Biotechnology, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2020

17. A clinical‐grade acellular matrix for esophageal replacement

Author

Arakelian, Lousineh, primary, Caille, Clémentine, additional, Faivre, Lionel, additional, Corté, Laurent, additional, Bruneval, Patrick, additional, Shamdani, Sara, additional, Flageollet, Camille, additional, Albanese, Patricia, additional, Domet, Thomas, additional, Jarraya, Mohamed, additional, Setterblad, Niclas, additional, Kellouche, Sabrina, additional, Larghero, Jérôme, additional, Cattan, Pierre, additional, and Vanneaux, Valérie, additional

Published
2019
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19. Circumferential Esophageal Replacement by a Tissue-engineered Substitute Using Mesenchymal Stem Cells

Author

Catry, Jonathan, primary, Luong-Nguyen, Minh, additional, Arakelian, Lousineh, additional, Poghosyan, Tigran, additional, Bruneval, Patrick, additional, Domet, Thomas, additional, Michaud, Laurent, additional, Sfeir, Rony, additional, Gottrand, Frederic, additional, Larghero, Jerome, additional, Vanneaux, Valerie, additional, and Cattan, Pierre, additional

Published
2017
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20. A Clinical-Grade Partially Decellularized Matrix for Tracheal Replacement: Validation In Vitro and In Vivo in a Porcine Model.

Author

Arakelian L, Léger M, Kellouche S, Agniel R, Bruneval P, Allain JM, Caputo V, Gendron N, Gozlan R, Bargui R, Vigouroux A, Sansac C, Jarraya M, Denoyelle F, Larghero J, and Thierry B

Abstract

The management of extensive tracheal resection followed by circumferential replacement remains a surgical challenge. Numerous techniques are proposed with mixed results. Partial decellularization of the trachea with the removal of the mucosal and submucosal cells is a promising method, reducing immunogenicity while preserving the biomechanical properties of the final matrix. Despite many research protocols and proofs of concept, no standardized clinical grade protocol is described. Furthermore, local and systemic biointegration mechanisms of decellularized trachea are not well known. Therefore, in a translational research perspective, this work set up a partial tracheal decellularization protocol in line with Cell and Tissue Products regulations. Extensive characterization of the final product is performed in vitro and in vivo. The results show that the Partially Decellularized Trachea (PDT) is cell-free in the mucosa and submucosa, while the cartilage structure is preserved, maintaining the biomechanical properties of the trachea. When implanted in the muscle in vivo for 28 days, no systemic inflammation is observed, and locally, the PDT shows an excellent biointegration and vascularization. No signs of graft rejection are observed. These encouraging results confirmed the efficacy of the clinical grade PDT production protocol, which is an important step for future clinical applications., (© 2024 The Author(s). Advanced Biology published by Wiley‐VCH GmbH.)

Published
2024
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