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278 results on '"Arakawa, Takeshi"'

2. Enhancing displacement ventilation performance: Proposal of a new portable air purifying displacement ventilation unit

Author

Essa Aya, Yamanaka Toshio, Choi Narae, Kobayashi Tomohiro, Kobayashi Noriaki, Komori Miharu, Matsui Nobuki, Okamoto Tetsuya, Arakawa Takeshi, Yamoto Yuki, and Otaka Shougo

Subjects
Environmental sciences, GE1-350
Abstract

Displacement Ventilation (DV) has been known as an energy saving system as it relies on buoyancy force to draw hot air upwards to be displaced by cool air. The main strength of DV that recommends it nowadays is that a well-designed DV system prevents mixing of contaminants as they are dragged along the hot air upward flow leaving the occupied zone, breathing zone in particular, clean. However, the system’s effectiveness is lowered in large rooms due to design problem such as difficult balance between sufficient supply flow volume and low inlet velocity, furniture arrangement acting as obstacles, or room geometry. Hence, DV feasibility is limited to small and mid-size rooms. In order to expand the DV potential and applicability to all space types and sizes, this study proposes a portable DV air purifying unit. The unit is designed to be mobile consisting of air recycling unit with no duct connections which widens the range of use to cover a variety of indoor spaces as well as small to medium sized room. The unit has two main functions, one is reinforcing the temperature gradient as stratification crucial for DV, and the second is purifying recycled air. To investigate the effectiveness and feasibility of the proposed DV unit, block model calculations and CFD analysis were conducted. In a basic office room, multiple cases were calculated and assessed in terms of temperature distribution and stratification height. In addition, exhaled contaminants were simulated and the contaminant concentration was used as an indicator for the air quality. Observations on the proposed unit’s performance and design aspects were highlighted.

Published
2023
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4. A novel portable cooling unit with air purification for displacement ventilation: Parametric study with zonal model and field experiment

Author

Essa, Aya, primary, Yamanaka, Toshio, additional, Choi, Narae, additional, Kobayashi, Tomohiro, additional, Kobayashi, Noriaki, additional, Komori, Miharu, additional, Matsui, Nobuki, additional, Okamoto, Tetsuya, additional, Arakawa, Takeshi, additional, Yamoto, Yuki, additional, and Otaka, Shogo, additional

Published
2023
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44. Oral Administration of Recombinant Live Yeast Producing Altered Peptide Ligand Derived from Insulin B:9-23 Peptide Linked to Cholera Toxin B Subunit Suppresses Development of Autoimmune Diabetes in NOD Mice

Author

Zhou, Hongbo, Abiru, Norio, Arakawa, Takeshi, Sakima, Rina, Miyata, Takeshi, Kobayashi, Masakazu, Fukushima, Keiko, Kawasaki, Eiji, Yamasaki, Hironori, and Eguchi, Katsumi

Subjects
Cholera toxin B subunit, Type 1 diabetes, Altered peptide ligand, Insulin, Oral tolerance, Yeast
Abstract

Insulin is a major autoantigen responsible for the pathogenesis of type 1 diabetes, and its B-chain peptide B:9-23 has been suggested to contain critically important epitopes in the NOD mouse. We have previously demonstrated that the altered peptide ligand of B:9-23 peptide with alanine substitutions at positions 16 and 19 (A16,19 APL) suppresses insulitis and reduces the incidence of diabetes when administered intranasally together with cholera toxin (CT). In this study, we extended the previous findings to determine whether mucosal administration of the A16,19APL without the use of toxic CT is efficacious for diabetes prevention. To this end,we linked the A16,19APL to the C-terminus of non-toxic cholera toxin (CTB) B subunit and the chimeric fusion protein was produced in methyloprophic yeast Pichia pastoris. Although intranasal administration of the recombinant CTB-A16,19APL fusion protein extracted fromthe yeast cells failed to prevent the progression to diabetes, oral administration of the live yeast cells producing the chimeric protein resulted in more than 50% reduction of the development of diabetes, albeit the fact that protective efficacy did not reach the significance level by life table analysis (P= 0.08). Furthermore, the expression of insulin autoantibodies was not altered throughout the course of oral immunization experiment. These results demonstrated that the efficacy of recombinant CTB-A16,19APL for oral immunization has much room for improvement. Nevertheless, oral administration of recombinant yeast or other edible materials such as food plants engineered to produce altered autoantigenic peptide could potentially become a novel non-invasive immunotherapeutic strategy for type 1 diabetes. (250 word), Acta medica Nagasakiensia, 54(2), pp.33-38 ; 2009

Published
2009

47. [Reveiw]There is Great Future in the Bio-Industry using the Technology of Gene Recombination

Author

NAGAMINE, Masaru, ARAKAWA, Takeshi, HASIMOTO, Naoko, ARAKAKI, Sakae, URASAKI, Naoya, Center of Molecular Biosciences University of the Ryukyus, Advanced Medical Biological Science Institute Co.,Ltd., and Okinawa Prefectural Experiment Station

Subjects
DNAワクチン, cholera toxin B chain, プラスミドDNA, edible vaccines, transgenic sugar cane, 食べるワクチン, 植物ワクチン, トタンスジェニックサトウキビ, DNA vaccines, plant-based vaccines, plasmid DNA, recombinant plant, コレラ毒素B鎖, 組み換え植物
Published
2005

48. [REVIEWS]Development of novel plant-based vaccine production and delivery systems

Author

Arakawa, Takeshi, Tadano, Masayuki, Ma, Shao-Ping, Toma, Hiromu, Sato, Shigetoshi, Kishimoto, Ayano, Nagamine, Masaru, Negishi, Tsutomu, Sato, Yoshiya, DePartment of Parasitology and Medical Biotechnology, University of the Ryukyus, Department of Virology, School of Medicine, University of the Ryukyus, Department of Bioproduction, School of Agriculture, University of the Ryukyus, and Gene Research Center, University of the Ryukyus

Subjects
植物遺伝子組換え, ワクチン, 植物工場, 機能性蛋白質
Published
2000

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