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3. Structural aging of human neurons is the opposite of the changes in schizophrenia

Author

Mizutani, Ryuta, Saiga, Rino, Yamamoto, Yoshiro, Uesugi, Masayuki, Takeuchi, Akihisa, Uesugi, Kentaro, Terada, Yasuko, Suzuki, Yoshio, De Andrade, Vincent, De Carlo, Francesco, Takekoshi, Susumu, Inomoto, Chie, Nakamura, Naoya, Torii, Youta, Kushima, Itaru, Iritani, Shuji, Ozaki, Norio, Oshima, Kenichi, Itokawa, Masanari, and Arai, Makoto

Subjects
Quantitative Biology - Neurons and Cognition, Physics - Biological Physics, Physics - Medical Physics, Quantitative Biology - Tissues and Organs
Abstract

Human mentality develops with age and is altered in psychiatric disorders, though their underlying mechanism is unknown. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the anterior cingulate cortex from eight schizophrenia and eight control cases. The distribution profiles of neurite curvature of the control cases showed a trend depending on their age, resulting in an age-correlated decrease in the standard deviation of neurite curvature (Pearson's r = -0.80, p = 0.018). In contrast to the control cases, the schizophrenia cases deviate upward from this correlation, exhibiting a 60% higher neurite curvature compared with the controls (p = 7.8 x 10^(-4)). The neurite curvature also showed a correlation with a hallucination score (Pearson's r = 0.80, p = 1.8 x 10^(-4)), indicating that neurite structure is relevant to brain function. We suggest that neurite curvature plays a pivotal role in brain aging and can be used as a hallmark to exploit a novel treatment of schizophrenia. This nano-CT paper is the result of our decade-long analysis and is unprecedented in terms of number of cases., Comment: 24 pages, 5 figures. arXiv admin note: text overlap with arXiv:2007.00212

Published
2022
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6. Mitochondrial biogenesis in white adipose tissue mediated by JMJD1A-PGC-1 axis limits age-related metabolic disease

Author

Ito, Ryo, Xie, Shiyu, Tumenjargal, Myagmar, Sugahara, Yuto, Yang, Chaoran, Takahashi, Hiroki, Arai, Makoto, Inoue, Shin-Ichi, Uchida, Aoi, Nakano, Kenji, Choi, Hyunmi, Yang, Ge, Zhao, Yanan, Yamaguchi, Rei, Jin, Hitomi, Sagae, Hina, Wada, Youichiro, Tanaka, Toshiya, Kimura, Hiroshi, Kodama, Tatsuhiko, Aburatani, Hiroyuki, Takeda, Kazuhisa, Inagaki, Takeshi, Osborne, Timothy F., Yoneshiro, Takeshi, Matsumura, Yoshihiro, and Sakai, Juro

Published
2024
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9. Schizophrenia-mimicking layers outperform conventional neural network layers

Author

Mizutani, Ryuta, Noguchi, Senta, Saiga, Rino, Yamashita, Yuichi, Miyashita, Mitsuhiro, Arai, Makoto, and Itokawa, Masanari

Subjects
Electrical Engineering and Systems Science - Image and Video Processing, Computer Science - Artificial Intelligence, Physics - Biological Physics
Abstract

We have reported nanometer-scale three-dimensional studies of brain networks of schizophrenia cases and found that their neurites are thin and tortuous compared to healthy controls. This suggests that connections between distal neurons are suppressed in microcircuits of schizophrenia cases. In this study, we applied these biological findings to the design of schizophrenia-mimicking artificial neural network to simulate the observed connection alteration in the disorder. Neural networks having a "schizophrenia connection layer" in place of a fully connected layer were subjected to image classification tasks using the MNIST and CIFAR-10 datasets. The results revealed that the schizophrenia connection layer is tolerant to overfitting and outperforms a fully connected layer. The outperformance was observed only for networks using band matrices as weight windows, indicating that the shape of the weight matrix is relevant to the network performance. A schizophrenia convolution layer was also tested using the VGG configuration, showing that 60% of the kernel weights of the last three convolution layers can be eliminated without loss of accuracy. The schizophrenia layers can be used instead of conventional layers without any change in the network configuration and training procedures; hence, neural networks can easily take advantage of these layers. The results of this study suggest that the connection alteration found in schizophrenia is not a burden to the brain, but has functional roles in brain performance., Comment: 16 pages, 6 figures, and 1 table

Published
2020
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10. Structural diverseness of neurons between brain areas and between cases

Author

Mizutani, Ryuta, Saiga, Rino, Yamamoto, Yoshiro, Uesugi, Masayuki, Takeuchi, Akihisa, Uesugi, Kentaro, Terada, Yasuko, Suzuki, Yoshio, De Andrade, Vincent, De Carlo, Francesco, Takekoshi, Susumu, Inomoto, Chie, Nakamura, Naoya, Torii, Youta, Kushima, Itaru, Iritani, Shuji, Ozaki, Norio, Oshima, Kenichi, Itokawa, Masanari, and Arai, Makoto

Subjects
Quantitative Biology - Neurons and Cognition, Physics - Biological Physics
Abstract

The cerebral cortex is composed of multiple cortical areas that exert a wide variety of brain functions. Although human brain neurons are genetically and areally mosaic, the three-dimensional structural differences between neurons in different brain areas or between the neurons of different individuals have not been delineated. Here, we report a nanometer-scale geometric analysis of brain tissues of the superior temporal gyrus of 4 schizophrenia and 4 control cases by using synchrotron radiation nanotomography. The results of the analysis and a comparison with results for the anterior cingulate cortex indicated that 1) neuron structures are dissimilar between brain areas and that 2) the dissimilarity varies from case to case. The structural diverseness was mainly observed in terms of the neurite curvature that inversely correlates with the diameters of the neurites and spines. The analysis also revealed the geometric differences between the neurons of the schizophrenia and control cases, suggesting that neuron structure is associated with brain function. The area dependency of the neuron structure and its diverseness between individuals should represent the individuality of brain functions., Comment: 3 figures

Published
2020

12. Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophrenia

Author

Ripke, Stephan, Neale, Benjamin M., Corvin, Aiden, Walters, James T.R., Farh, Kai-How, Holmans, Peter A., Lee, Phil, Bulik-Sullivan, Brendan, Collier, David A., Huang, Hailiang, Pers, Tune H., Agartz, Ingrid, Agerbo, Esben, Albus, Margot, Alexander, Madeline, Amin, Farooq, Bacanu, Silviu A., Begemann, Martin, Belliveau, Richard A., Jr., Bene, Judit, Bergen, Sarah E., Bevilacqua, Elizabeth, Bigdeli, Tim B., Black, Donald W., Bruggeman, Richard, Buccola, Nancy G., Buckner, Randy L., Byerley, William, Cahn, Wiepke, Cai, Guiqing, Campion, Dominique, Cantor, Rita M., Carr, Vaughan J., Carrera, Noa, Catts, Stanley V., Chambert, Kimberley D., Chan, Raymond C.K., Chan, Ronald Y.L., Chen, Eric Y.H., Cheng, Wei, Cheung, Eric FC., Chong, Siow Ann, Cloninger, C. Robert, Cohen, David, Cohen, Nadine, Cormican, Paul, Craddock, Nick, Crowley, James J., Curtis, David, Davidson, Michael, Davis, Kenneth L., Degenhardt, Franziska, Del Favero, Jurgen, Demontis, Ditte, Dikeos, Dimitris, Dinan, Timothy, Djurovic, Srdjan, Donohoe, Gary, Drapeau, Elodie, Duan, Jubao, Dudbridge, Frank, Durmishi, Naser, Eichhammer, Peter, Eriksson, Johan, Escott-Price, Valentina, Essioux, Laurent, Fanous, Ayman H., Farrell, Martilias S., Frank, Josef, Franke, Lude, Freedman, Robert, Freimer, Nelson B., Friedl, Marion, Friedman, Joseph I., Fromer, Menachem, Genovese, Giulio, Georgieva, Lyudmila, Giegling, Ina, Giusti-Rodríguez, Paola, Godard, Stephanie, Goldstein, Jacqueline I., Golimbet, Vera, Gopal, Srihari, Gratten, Jacob, de Haan, Lieuwe, Hammer, Christian, Hamshere, Marian L., Hansen, Mark, Hansen, Thomas, Haroutunian, Vahram, Hartmann, Annette M., Henskens, Frans A., Herms, Stefan, Hirschhorn, Joel N., Hoffmann, Per, Hofman, Andrea, Hollegaard, Mads V., Hougaard, David M., Ikeda, Masashi, Joa, Inge, Julià, Antonio, Kahn, René S., Kalaydjieva, Luba, Karachanak-Yankova, Sena, Karjalainen, Juha, Kavanagh, David, Keller, Matthew C., Kennedy, James L., Khrunin, Andrey, Kim, Yunjung, Klovins, Janis, Knowles, James A., Konte, Bettina, Kucinskas, Vaidutis, Kucinskiene, Zita Ausrele, Kuzelova-Ptackova, Hana, Kähler, Anna K., Laurent, Claudine, Lee, Jimmy, Lee, S. Hong, Legge, Sophie E., Lerer, Bernard, Li, Miaoxin, Li, Tao, Liang, Kung-Yee, Lieberman, Jeffrey, Limborska, Svetlana, Loughland, Carmel M., Lubinski, Jan, Lönnqvist, Jouko, Macek, Milan, Magnusson, Patrik K.E., Maher, Brion S., Maier, Wolfgang, Mallet, Jacques, Marsal, Sara, Mattheisen, Manuel, Mattingsdal, Morten, McCarley, Robert W., McDonald, Colm, McIntosh, Andrew M., Meier, Sandra, Meijer, Carin J., Melegh, Bela, Melle, Ingrid, Mesholam-Gately, Raquelle I., Metspalu, Andres, Michie, Patricia T., Milani, Lili, Milanova, Vihra, Mokrab, Younes, Morris, Derek W., Mors, Ole, Murphy, Kieran C., Murray, Robin M., Myin-Germeys, Inez, Müller-Myhsok, Bertram, Nelis, Mari, Nenadic, Igor, Nertney, Deborah A., Nestadt, Gerald, Nicodemus, Kristin K., Nikitina-Zake, Liene, Nisenbaum, Laura, Nordin, Annelie, O'Callaghan, Eadbhard, O'Dushlaine, Colm, O'Neill, F. Anthony, Oh, Sang-Yun, Olincy, Ann, Olsen, Line, Van Os, Jim, Pantelis, Christos, Papadimitriou, George N., Papiol, Sergi, Parkhomenko, Elena, Pato, Michele T., Paunio, Tiina, Pejovic-Milovancevic, Milica, Perkins, Diana O., Pietiläinen, Olli, Pimm, Jonathan, Pocklington, Andrew J., Powell, John, Price, Alkes, Pulver, Ann E., Purcell, Shaun M., Quested, Digby, Rasmussen, Henrik B., Reichenberg, Abraham, Reimers, Mark A., Richards, Alexander L., Roffman, Joshua L., Roussos, Panos, Ruderfer, Douglas M., Salomaa, Veikko, Sanders, Alan R., Schall, Ulrich, Schubert, Christian R., Schulze, Thomas G., Schwab, Sibylle G., Scolnick, Edward M., Scott, Rodney J., Seidman, Larry J., Shi, Jianxin, Sigurdsson, Engilbert, Silagadze, Teimuraz, Silverman, Jeremy M., Sim, Kang, Slominsky, Petr, Smoller, Jordan W., So, Hon-Cheong, Spencer, Chris C.A., Stahl, Eli A., Stefansson, Hreinn, Steinberg, Stacy, Stogmann, Elisabeth, Straub, Richard E., Strengman, Eric, Strohmaier, Jana, Stroup, T Scott, Subramaniam, Mythily, Suvisaari, Jaana, Svrakic, Dragan M., Szatkiewicz, Jin P., Söderman, Erik, Thirumalai, Srinivas, Toncheva, Draga, Tosato, Sarah, Veijola, Juha, Waddington, John, Walsh, Dermot, Wang, Dai, Wang, Qiang, Webb, Bradley T., Weiser, Mark, Wildenauer, Dieter B., Williams, Nigel M., Williams, Stephanie, Witt, Stephanie H., Wolen, Aaron R., Wong, Emily H.M., Wormley, Brandon K., Xi, Hualin Simon, Zai, Clement C., Zheng, Xuebin, Zimprich, Fritz, Wray, Naomi R., Stefansson, Kari, Visscher, Peter M., Adolfsson, Rolf, Andreassen, Ole A., Blackwood, Douglas H.R., Bramon, Elvira, Buxbaum, Joseph D., Børglum, Anders D., Cichon, Sven, Darvasi, Ariel, Domenici, Enrico, Ehrenreich, Hannelore, Esko, Tõnu, Gejman, Pablo V., Gill, Michael, Gurling, Hugh, Hultman, Christina M., Iwata, Nakao, Jablensky, Assen V., Jönsson, Erik G., Kendler, Kenneth S., Kirov, George, Knight, Jo, Lencz, Todd, Levinson, Douglas F., Li, Qingqin S., Liu, Jianjun, Malhotra, Anil K., McCarroll, Steven A., McQuillin, Andrew, Moran, Jennifer L., Mortensen, Preben B., Mowry, Bryan J., Nöthen, Markus M., Ophoff, Roel A., Owen, Michael J., Palotie, Aarno, Pato, Carlos N., Petryshen, Tracey L., Posthuma, Danielle, Rietschel, Marcella, Riley, Brien P., Rujescu, Dan, Sham, Pak C., Sklar, Pamela, St Clair, David, Weinberger, Daniel R., Wendland, Jens R., Werge, Thomas, Daly, Mark J., Sullivan, Patrick F., O'Donovan, Michael C., Qin, Shengying, Sawa, Akira, Kahn, Rene, Hong, Kyung Sue, Shi, Wenzhao, Tsuang, Ming, Itokawa, Masanari, Feng, Gang, Glatt, Stephen J., Ma, Xiancang, Tang, Jinsong, Ruan, Yunfeng, Liu, Ruize, Zhu, Feng, Horiuchi, Yasue, Lee, Byung Dae, Joo, Eun-Jeong, Myung, Woojae, Ha, Kyooseob, Won, Hong-Hee, Baek, Ji Hyung, Chung, Young Chul, Kim, Sung-Wan, Kusumawardhani, Agung, Chen, Wei J., Hwu, Hai-Gwo, Hishimoto, Akitoyo, Otsuka, Ikuo, Sora, Ichiro, Toyota, Tomoko, Yoshikawa, Takeo, Kunugi, Hiroshi, Hattori, Kotaro, Ishiwata, Sayuri, Numata, Shusuke, Ohmori, Tetsuro, Arai, Makoto, Ozeki, Yuji, Fujii, Kumiko, Kim, Se Joo, Lee, Heon-Jeong, Ahn, Yong Min, Kim, Se Hyun, Akiyama, Kazufumi, Shimoda, Kazutaka, Kinoshita, Makoto, Hsu, Yu-Han H., Pintacuda, Greta, Nacu, Eugeniu, Kim, April, Tsafou, Kalliopi, Petrossian, Natalie, Crotty, William, Suh, Jung Min, Riseman, Jackson, Martin, Jacqueline M., Biagini, Julia C., Mena, Daya, Ching, Joshua K.T., Malolepsza, Edyta, Li, Taibo, Singh, Tarjinder, Ge, Tian, Egri, Shawn B., Tanenbaum, Benjamin, Stanclift, Caroline R., Apffel, Annie M., Carr, Steven A., Schenone, Monica, Jaffe, Jake, Fornelos, Nadine, Eggan, Kevin C., and Lage, Kasper

Published
2023
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14. Liver biopsy technique in the era of genomic cancer therapies: a single-center retrospective analysis

Author

Ozeki, Yusuke, Kanogawa, Naoya, Ogasawara, Sadahisa, Ogawa, Keita, Ishino, Takamasa, Nakagawa, Miyuki, Fujiwara, Kisako, Unozawa, Hidemi, Iwanaga, Terunao, Sakuma, Takafumi, Fujita, Naoto, Kojima, Ryuta, Kanzaki, Hiroaki, Koroki, Keisuke, Kobayashi, Kazufumi, Nakamura, Masato, Kiyono, Soichiro, Kondo, Takayuki, Saito, Tomoko, Nakagawa, Ryo, Suzuki, Eiichiro, Ooka, Yoshihiko, Nakamoto, Shingo, Muroyama, Ryosuke, Tawada, Akinobu, Chiba, Tetsuhiro, Arai, Makoto, Kato, Jun, Ikeda, Jun-ichiro, Takiguchi, Yuichi, and Kato, Naoya

Published
2022
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18. Three-dimensional alteration of neurites in schizophrenia

Author

Mizutani, Ryuta, Saiga, Rino, Takeuchi, Akihisa, Uesugi, Kentaro, Terada, Yasuko, Suzuki, Yoshio, De Andrade, Vincent, De Carlo, Francesco, Takekoshi, Susumu, Inomoto, Chie, Nakamura, Naoya, Kushima, Itaru, Iritani, Shuji, Ozaki, Norio, Ide, Soichiro, Ikeda, Kazutaka, Oshima, Kenichi, Itokawa, Masanari, and Arai, Makoto

Subjects
Quantitative Biology - Neurons and Cognition, Physics - Biological Physics
Abstract

This paper reports nano-CT analysis of brain tissues of schizophrenia and control cases. The analysis revealed that: (1) neuronal structures vary between individuals, (2) the mean curvature of distal neurites of the schizophrenia cases was 1.5 times higher than that of the controls, and (3) dendritic spines were categorized into two geometrically distinctive groups, though no structural differences were observed between the disease and control cases. The differences in the neurite curvature result in differences in the spatial trajectory and hence alter neuronal circuits. We suggest that the structural alteration of neurons in the schizophrenia cases should reflect psychiatric symptoms of schizophrenia., Comment: 24 pages, 4 figures, and 1 table. Supplementary materials are available from DOI link

Published
2018
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19. Real-world outcomes of chemotherapy for lung cancer patients undergoing hemodialysis: A multicenter retrospective cohort study (NEJ-042)

Author

Minegishi, Yuji, Akagami, Tomoe, Arai, Makoto, Saito, Ryota, Arai, Daisuke, Murase, Kyoko, Miura, Keita, Watanabe, Satoshi, Sakashita, Hiroyuki, Miyabayashi, Takao, Honda, Ryoichi, Jingu, Daisuke, Hotta, Takamasa, Isobe, Kazutoshi, Nakazawa, Kensuke, Ito, Kenichiro, Takamura, Kei, Inomata, Minehiko, Harada, Toshiyuki, Sakakibara, Rie, Nakagawa, Taku, Shibuya, Hideki, Takenaka, Kiyoshi, Kobayashi, Kunihiko, and Seike, Masahiro

Published
2022
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20. Development and evaluation of a double-check support system using artificial intelligence in endoscopic screening for gastric cancer

Author

Oura, Hirotaka, Matsumura, Tomoaki, Fujie, Mai, Ishikawa, Tsubasa, Nagashima, Ariki, Shiratori, Wataru, Tokunaga, Mamoru, Kaneko, Tatsuya, Imai, Yushi, Oike, Tsubasa, Yokoyama, Yuya, Akizue, Naoki, Ota, Yuki, Okimoto, Kenichiro, Arai, Makoto, Nakagawa, Yuki, Inada, Mari, Yamaguchi, Kazuya, Kato, Jun, and Kato, Naoya

Published
2022
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21. Evidence-based clinical practice guidelines for functional dyspepsia 2021

Author

Miwa, Hiroto, Nagahara, Akihito, Asakawa, Akihiro, Arai, Makoto, Oshima, Tadayuki, Kasugai, Kunio, Kamada, Kazuhiro, Suzuki, Hidekazu, Tanaka, Fumio, Tominaga, Kazunari, Futagami, Seiji, Hojo, Mariko, Mihara, Hiroshi, Higuchi, Kazuhide, Kusano, Motoyasu, Arisawa, Tomiyasu, Kato, Mototsugu, Joh, Takashi, Mochida, Satoshi, Enomoto, Nobuyuki, Shimosegawa, Tooru, and Koike, Kazuhiko

Published
2022
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23. Outcomes of long-term nivolumab and subsequent chemotherapy in Japanese patients with head and neck cancer: 2-year follow-up from a multicenter real-world study

Author

Yasumatsu, Ryuji, Shimizu, Yasushi, Hanai, Nobuhiro, Kariya, Shin, Yokota, Tomoya, Fujii, Takashi, Tsukahara, Kiyoaki, Ando, Mizuo, Hanyu, Kenji, Ueda, Tsutomu, Hirakawa, Hitoshi, Takahashi, Shunji, Ono, Takeharu, Sano, Daisuke, Yamauchi, Moriyasu, Watanabe, Akihito, Omori, Koichi, Yamazaki, Tomoko, Monden, Nobuya, Kudo, Naomi, Arai, Makoto, Yonekura, Syuji, Asakage, Takahiro, Nekado, Takahiro, Yamada, Takayuki, and Homma, Akihiro

Published
2022
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24. MYPT1-PP1β phosphatase negatively regulates both chromatin landscape and co-activator recruitment for beige adipogenesis

Author

Takahashi, Hiroki, Yang, Ge, Yoneshiro, Takeshi, Abe, Yohei, Ito, Ryo, Yang, Chaoran, Nakazono, Junna, Okamoto-Katsuyama, Mayumi, Uchida, Aoi, Arai, Makoto, Jin, Hitomi, Choi, Hyunmi, Tumenjargal, Myagmar, Xie, Shiyu, Zhang, Ji, Sagae, Hina, Zhao, Yanan, Yamaguchi, Rei, Nomura, Yu, Shimizu, Yuichi, Yamada, Kaito, Yasuda, Satoshi, Kimura, Hiroshi, Tanaka, Toshiya, Wada, Youichiro, Kodama, Tatsuhiko, Aburatani, Hiroyuki, Zhu, Min-Sheng, Inagaki, Takeshi, Osborne, Timothy F., Kawamura, Takeshi, Ishihama, Yasushi, Matsumura, Yoshihiro, and Sakai, Juro

Published
2022
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25. Role of advanced glycation end products in the longitudinal association between muscular strength and psychotic symptoms among adolescents

Author

Suzuki, Kazuhiro, Yamasaki, Syudo, Miyashita, Mitsuhiro, Ando, Shuntaro, Toriumi, Kazuya, Yoshikawa, Akane, Nakanishi, Miharu, Morimoto, Yuko, Kanata, Sho, Fujikawa, Shinya, Endo, Kaori, Koike, Shinsuke, Usami, Satoshi, Itokawa, Masanari, Washizuka, Shinsuke, Hiraiwa-Hasegawa, Mariko, Meltzer, Herbert Y., Kasai, Kiyoto, Nishida, Atsushi, and Arai, Makoto

Published
2022
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26. The efficacy of contrast-enhanced computed tomography on the management of gastroesophageal varices in patients with hepatocellular carcinoma

Author

Kondo, Takayuki, Fujiwara, Kisako, Nakagawa, Miyuki, Unozawa, Hidemi, Iwanaga, Terunao, Sakuma, Takafumi, Fujita, Naoto, Koroki, Keisuke, Kanzaki, Hiroaki, Kobayashi, Kazufumi, Kiyono, Soichiro, Nakamura, Masato, Kanogawa, Naoya, Saito, Tomoko, Ogasawara, Sadahisa, Suzuki, Eiichiro, Ooka, Yoshihiko, Nakamoto, Shingo, Chiba, Tetsuhiro, Arai, Makoto, Kato, Jun, and Kato, Naoya

Published
2022
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27. The long-term effect of biologics in patients with ulcerative colitis emerging from a large Japanese cohort

Author

Yokoyama, Yuya, Ohta, Yuki, Ogasawara, Sadahisa, Kato, Jun, Arai, Ryoko, Koseki, Hirotaka, Saito, Masaya, Kaneko, Tatsuya, Tokunaga, Mamoru, Oura, Hirotaka, Oike, Tsubasa, Imai, Yushi, Kanayama, Kengo, Akizue, Naoki, Kumagai, Junichiro, Taida, Takashi, Okimoto, Kenichiro, Saito, Keiko, Ooka, Yoshihiko, Matsumura, Tomoaki, Nakagawa, Tomoo, Arai, Makoto, Katsuno, Tatsuro, Fukuda, Yoshihiro, Kitsukawa, Yoshio, and Kato, Naoya

Published
2022
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28. Hair zinc levels and psychosis risk among adolescents

Author

Tabata, Koichi, Miyashita, Mitsuhiro, Yamasaki, Syudo, Toriumi, Kazuya, Ando, Shuntaro, Suzuki, Kazuhiro, Endo, Kaori, Morimoto, Yuko, Tomita, Yasufumi, Yamaguchi, Satoshi, Usami, Satoshi, Itokawa, Masanari, Hiraiwa-Hasegawa, Mariko, Takahashi, Hidehiko, Kasai, Kiyoto, Nishida, Atsushi, and Arai, Makoto

Published
2022
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29. Study on the Influence of Liquid Sloshing on FLNG Motion

Author

Nakashima, Akira, Arai, Makoto, Nishimoto, Kazuo, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Okada, Tetsuo, editor, Suzuki, Katsuyuki, editor, and Kawamura, Yasumi, editor

Published
2021
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30. Numerical Assessment of Sloshing Loads in Rectangular Tanks Equipped with Perforated Swash Bulkhead Under Large Excitations

Author

Bellezi, Cezar Augusto, Cheng, Liang-Yee, Okada, Tetsuo, Arai, Makoto, di Prisco, Marco, Series Editor, Chen, Sheng-Hong, Series Editor, Vayas, Ioannis, Series Editor, Kumar Shukla, Sanjay, Series Editor, Sharma, Anuj, Series Editor, Kumar, Nagesh, Series Editor, Wang, Chien Ming, Series Editor, Okada, Tetsuo, editor, Suzuki, Katsuyuki, editor, and Kawamura, Yasumi, editor

Published
2021
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32. Estimating the resolution of real images

Author

Mizutani, Ryuta, Saiga, Rino, Takekoshi, Susumu, Inomoto, Chie, Nakamura, Naoya, Arai, Makoto, Oshima, Kenichi, Itokawa, Masanari, Takeuchi, Akihisa, Uesugi, Kentaro, Terada, Yasuko, and Suzuki, Yoshio

Subjects
Physics - Data Analysis, Statistics and Probability, Computer Science - Computer Vision and Pattern Recognition, Physics - Medical Physics
Abstract

Image resolvability is the primary concern in imaging. This paper reports an estimation of the full width at half maximum of the point spread function from a Fourier domain plot of real sample images by neither using test objects, nor defining a threshold criterion. We suggest that this method can be applied to any type of image, independently of the imaging modality., Comment: 4 pages, 2 figures

Published
2017
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35. A method for estimating spatial resolution of real image in the Fourier domain

Author

Mizutani, Ryuta, Saiga, Rino, Takekoshi, Susumu, Inomoto, Chie, Nakamura, Naoya, Itokawa, Masanari, Arai, Makoto, Oshima, Kenichi, Takeuchi, Akihisa, Uesugi, Kentaro, Terada, Yasuko, and Suzuki, Yoshio

Subjects
Physics - Data Analysis, Statistics and Probability, Physics - Biological Physics, Physics - Instrumentation and Detectors
Abstract

Spatial resolution is a fundamental parameter in structural sciences. In crystallography, the resolution is determined from the detection limit of high-angle diffraction in reciprocal space. In electron microscopy, correlation in the Fourier domain is used for estimating the resolution. In this paper, we report a method for estimating the spatial resolution of real images from a logarithmic intensity plot in the Fourier domain. The logarithmic intensity plots of test images indicated that the full width at half maximum of a Gaussian point-spread function can be estimated from the images. The spatial resolution of imaging X-ray microtomography using Fresnel zone-plate optics was also estimated with this method. A cross section of a test object visualized with the imaging microtomography indicated that square-wave patterns up to 120-nm pitch were resolved. The logarithmic intensity plot was calculated from a tomographic cross section of brain tissue. The full width at half maximum of the point spread function estimated from the plot coincided with the resolution determined from the test object. These results indicated that the logarithmic intensity plot in the Fourier domain provides an alternative measure of the spatial resolution without explicitly defining a noise criterion., Comment: 27 pages, 8 figures, 1 table

Published
2016
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37. Effectiveness of nivolumab affected by prior cetuximab use and neck dissection in Japanese patients with recurrent or metastatic head and neck cancer: results from a retrospective observational study in a real-world setting

Author

Kariya, Shin, Shimizu, Yasushi, Hanai, Nobuhiro, Yasumatsu, Ryuji, Yokota, Tomoya, Fujii, Takashi, Tsukahara, Kiyoaki, Yoshida, Masafumi, Hanyu, Kenji, Ueda, Tsutomu, Hirakawa, Hitoshi, Takahashi, Shunji, Ono, Takeharu, Sano, Daisuke, Yamauchi, Moriyasu, Watanabe, Akihito, Omori, Koichi, Yamazaki, Tomoko, Monden, Nobuya, Kudo, Naomi, Arai, Makoto, Yonekura, Shuji, Asakage, Takahiro, Fujiwara, Akinori, Yamada, Takayuki, and Homma, Akihiro

Published
2021
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38. Effectiveness and safety of nivolumab in patients with head and neck cancer in Japanese real-world clinical practice: a multicenter retrospective clinical study

Author

Hanai, Nobuhiro, Shimizu, Yasushi, Kariya, Shin, Yasumatsu, Ryuji, Yokota, Tomoya, Fujii, Takashi, Tsukahara, Kiyoaki, Yoshida, Masafumi, Hanyu, Kenji, Ueda, Tsutomu, Hirakawa, Hitoshi, Takahashi, Shunji, Ono, Takeharu, Sano, Daisuke, Yamauchi, Moriyasu, Watanabe, Akihito, Omori, Koichi, Yamazaki, Tomoko, Monden, Nobuya, Kudo, Naomi, Arai, Makoto, Sakurai, Daiju, Asakage, Takahiro, Doi, Issei, Yamada, Takayuki, and Homma, Akihiro

Published
2021
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45. Genetic profiles of Barrett’s esophagus and esophageal adenocarcinoma in Japanese patients

Author

Tokunaga, Mamoru, Okimoto, Kenichiro, Akizue, Naoki, Ishikawa, Kentaro, Hirotsu, Yosuke, Amemiya, Kenji, Ota, Masayuki, Matsusaka, Keisuke, Nishimura, Motoi, Matsushita, Kazuyuki, Ishikawa, Tsubasa, Nagashima, Ariki, Shiratori, Wataru, Kaneko, Tatsuya, Oura, Hirotaka, Kanayama, Kengo, Ohta, Yuki, Taida, Takashi, Saito, Keiko, Matsumura, Tomoaki, Chiba, Tetsuhiro, Mochizuki, Hitoshi, Arai, Makoto, Kato, Jun, Ikeda, Jun-ichiro, Omata, Masao, and Kato, Naoya

Published
2021
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46. A structured summary of a study protocol for a multi-center, randomized controlled trial (RCT) of COVID-19 prevention with Kampo medicines (Integrative Management in Japan for Epidemic Disease by prophylactic study: IMJEDI P1 study)

Author

Namiki, Takao, Takayama, Shin, Arita, Ryutaro, Ishii, Tadashi, Kainuma, Mosaburo, Makino, Toshiaki, Mimura, Masaru, Yoshino, Tetsuhiro, Nogami, Tatsuya, Arai, Makoto, Sato, Juichi, Tanaka, Koichiro, Nakae, Hajime, Igari, Hidetoshi, Ozawa, Yoshihito, Shiko, Yuki, Kawasaki, Yohei, Nezu, Masahiko, and Ito, Takashi

Published
2021
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49. The impact of FGF19/FGFR4 signaling inhibition in antitumor activity of multi-kinase inhibitors in hepatocellular carcinoma

Author

Kanzaki, Hiroaki, Chiba, Tetsuhiro, Ao, Junjie, Koroki, Keisuke, Kanayama, Kengo, Maruta, Susumu, Maeda, Takahiro, Kusakabe, Yuko, Kobayashi, Kazufumi, Kanogawa, Naoya, Kiyono, Soichiro, Nakamura, Masato, Kondo, Takayuki, Saito, Tomoko, Nakagawa, Ryo, Ogasawara, Sadahisa, Suzuki, Eiichiro, Ooka, Yoshihiko, Muroyama, Ryosuke, Nakamoto, Shingo, Yasui, Shin, Tawada, Akinobu, Arai, Makoto, Kanda, Tatsuo, Maruyama, Hitoshi, Mimura, Naoya, Kato, Jun, Zen, Yoh, Ohtsuka, Masayuki, Iwama, Atsushi, and Kato, Naoya

Published
2021
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50. Fingertip advanced glycation end products and psychotic symptoms among adolescents

Author

Miyashita, Mitsuhiro, Yamasaki, Syudo, Ando, Shuntaro, Suzuki, Kazuhiro, Toriumi, Kazuya, Horiuchi, Yasue, Yoshikawa, Akane, Imai, Atsushi, Nagase, Yukihiro, Miyano, Yasuhiro, Inoue, Tomoko, Endo, Kaori, Morimoto, Yuko, Morita, Masaya, Kiyono, Tomoki, Usami, Satoshi, Okazaki, Yuji, Furukawa, Toshiaki A., Hiraiwa-Hasegawa, Mariko, Itokawa, Masanari, Kasai, Kiyoto, Nishida, Atsushi, and Arai, Makoto

Published
2021
Full Text
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