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301 results on '"Arab-Tehrany, Elmira"'

4. Breathable hydrogel dressings containing natural antioxidants for management of skin disorders

Author

Comotto, Mattia, Saghazadeh, Saghi, Bagherifard, Sara, Aliakbarian, Bahar, Kazemzadeh-Narbat, Mehdi, Sharifi, Fatemeh, Shaegh, Seyed Ali Mousavi, Arab-Tehrany, Elmira, Annabi, Nasim, Perego, Patrizia, Khademhosseini, Ali, and Tamayol, Ali

Subjects
Engineering, Biomedical Engineering, Nutrition, Bioengineering, Complementary and Integrative Health, Alginates, Anti-Bacterial Agents, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Bandages, Biocompatible Materials, Curcumin, Drug Delivery Systems, Drug Liberation, Humans, Hydrogels, Oxygen, Resveratrol, Skin Diseases, Staphylococcal Infections, Staphylococcus aureus, wet wound dressings, alginate, curcumin, t-resveratrol, Materials Engineering, Biomedical engineering, Materials engineering
Abstract

Traditional wound dressings are not effective enough to regulate the moisture content and remove excessive exudate from the environment. Wet wound dressings formed from hydrogels such as alginate are widely used in clinical practice for treatment of skin disorders. Here, we functionalize alginate dressings with natural antioxidants such as curcumin and t-resveratrol to render them both anti-inflammatory and antibacterial. The hydrogel maintains excellent mechanical properties and oxygen permeability over time. The release rate of the compounds from the hydrogels is assessed and their impact on bacterial and cellular growth is evaluated. The antioxidant compounds act as bactericidal agents and improve cell viability. The optimal concentration of active compounds in the engineered alginate-based dressings is determined.

Published
2019

6. Natural lecithin promotes neural network complexity and activity.

Author

Latifi, Shahrzad, Tamayol, Ali, Habibey, Rouhollah, Sabzevari, Reza, Kahn, Cyril, Geny, David, Eftekharpour, Eftekhar, Annabi, Nasim, Blau, Axel, Linder, Michel, and Arab-Tehrany, Elmira

Subjects
Nerve Net, Neurons, Mitochondria, Animals, Rats, Synapsins, RNA, Messenger, Liposomes, Microelectrodes, Nanoparticles, Lecithins, Complementary and Alternative Medicine, Neurosciences, Neurological, RNA, Messenger, Biochemistry and Cell Biology, Other Physical Sciences
Abstract

Phospholipids in the brain cell membranes contain different polyunsaturated fatty acids (PUFAs), which are critical to nervous system function and structure. In particular, brain function critically depends on the uptake of the so-called "essential" fatty acids such as omega-3 (n-3) and omega-6 (n-6) PUFAs that cannot be readily synthesized by the human body. We extracted natural lecithin rich in various PUFAs from a marine source and transformed it into nanoliposomes. These nanoliposomes increased neurite outgrowth, network complexity and neural activity of cortical rat neurons in vitro. We also observed an upregulation of synapsin I (SYN1), which supports the positive role of lecithin in synaptogenesis, synaptic development and maturation. These findings suggest that lecithin nanoliposomes enhance neuronal development, which may have an impact on devising new lecithin delivery strategies for therapeutic applications.

Published
2016

7. Bioactive Fibers: Hydrogel Templates for Rapid Manufacturing of Bioactive Fibers and 3D Constructs (Adv. Healthcare Mater. 14/2015)

Author

Tamayol, Ali, Najafabadi, Alireza Hassani, Aliakbarian, Bahar, Arab-Tehrany, Elmira, Akbari, Mohsen, Annabi, Nasim, Juncker, David, and Khademhosseini, Ali

Subjects
Engineering, Materials Engineering, Biomedical Engineering, Bioengineering, bioprinting, cell-laden fibers, fiber-based methods, sacrificial polymeric networks, tissue engineering, Medicinal and Biomolecular Chemistry, Medical Biotechnology, Medical biotechnology, Biomedical engineering
Abstract

Hybrid hydrogel fibers were fabricated using hydrogel templates. On page 2146, D. Juncker, A. Khademhosseini, and co-workers show how these fibers containing different fluorescent microbeads have been assembled using textile processes, such as braiding and weaving, to create complex 3D patterns for bioengineering applications. The fabricated constructs with clinically relevant dimensions are mechanically stable.

Published
2015

8. Hydrogel Templates for Rapid Manufacturing of Bioactive Fibers and 3D Constructs

Author

Tamayol, Ali, Najafabadi, Alireza Hassani, Aliakbarian, Bahar, Arab-Tehrany, Elmira, Akbari, Mohsen, Annabi, Nasim, Juncker, David, and Khademhosseini, Ali

Subjects
Bioengineering, bioprinting, cell-laden fibers, fiber-based methods, sacrificial polymeric networks, tissue engineering, Medicinal and Biomolecular Chemistry, Biomedical Engineering, Medical Biotechnology
Abstract

Hydrogel templates are formed to entrap various pre-polymers prior to their crosslinking process. Upon the completion of the crosslinking process, an independent polymer network with the same fiber geometry is formed. The hydrogel template can be removed if necessary. As the proof-of-principle, fibers from various polymers are fabricated. The fabricated hybrid polymeric fibers are bioactive and can be bioprinted or assembled using textile processes. The approach can be used for creating complex 3D constructs for various applications.

Published
2015

10. Contributors

Author

Arab-Tehrany, Elmira, primary, Aytekin, Ali Özhan, additional, Bajpai, A.K., additional, Das, Madhurima, additional, Das, Subhraseema, additional, Dey, Madhumita, additional, Dey, Nibedita, additional, Dutta, Pallobi, additional, Elkhoury, Kamil, additional, Espinosa-Duque, Arturo, additional, García-Quintero, Angélica, additional, George, Jinu, additional, Ghosh, Bijaya, additional, Giri, Saumyakanti, additional, Giri, Tapan Kumar, additional, John, Franklin, additional, Joy, Reshma, additional, Kahali, Nancy, additional, Kahn, Cyril, additional, Karthigadevi, G., additional, Kayra, Neslihan, additional, Kirtania, Moumita Das, additional, Koraltan, Yaprak Petek, additional, Kumarasamy, Dhanabal, additional, Maheriya, Pankaj M., additional, Maity, Arindam, additional, Malar, Carlin Geor, additional, Mukherjee, Shubham, additional, Nagaraja, Kasula, additional, Otálora, Andrés, additional, Palencia, Manuel, additional, Patra, Falguni, additional, Pinho, Eva, additional, Prajapati, Vipul D., additional, Rao, Kummara Madhusudana, additional, Rao, Kummari S.V. Krishna, additional, Roseline, Maria Sarah, additional, Roy, Salona D., additional, Sánchez-González, Laura, additional, Sathish Kumar, K., additional, Shrivastava, Jyoti, additional, Subalakshmi, V., additional, Subuddhi, Usharani, additional, Sun, Xiao-Feng, additional, Vigneshkumar, P.N., additional, Wang, Hai-Hong, additional, and Zhang, Tao, additional

Published
2021
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11. Neuroprotective Effect of Curcumin-Loaded RGD Peptide-PEGylated Nanoliposomes

Author

Ben Mihoub, Amina, primary, Elkhoury, Kamil, additional, Nel, Janske, additional, Acherar, Samir, additional, Velot, Emilie, additional, Malaplate, Catherine, additional, Linder, Michel, additional, Latifi, Shahrzad, additional, Kahn, Cyril, additional, Huguet, Marion, additional, Yen, Frances T., additional, and Arab-Tehrany, Elmira, additional

Published
2023
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12. Gelatin Methacryloyl (GelMA) Hydrogel Scaffolds: Predicting Physical Properties Using an Experimental Design Approach

Author

Peyret, Corentin, primary, Elkhoury, Kamil, additional, Bouguet-Bonnet, Sabine, additional, Poinsignon, Sophie, additional, Boulogne, Corentin, additional, Giraud, Tristan, additional, Stefan, Loïc, additional, Tahri, Yasmina, additional, Sanchez-Gonzalez, Laura, additional, Linder, Michel, additional, Tamayol, Ali, additional, Kahn, Cyril J.F., additional, and Arab-Tehrany, Elmira, additional

Published
2023
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21. Hybrid extracellular vesicles-liposome incorporated advanced bioink to deliver microRNA

Author

Elkhoury, Kamil, primary, Chen, Mo, additional, Koçak, Polen, additional, Enciso-Martínez, Eduardo, additional, Bassous, Nicole Joy, additional, Lee, Myung Chul, additional, Byambaa, Batzaya, additional, Rezaei, Zahra, additional, Li, Yang, additional, Ubina López, María Elizabeth, additional, Gurian, Melvin, additional, Sobahi, Nebras, additional, Hussain, Mohammad Asif, additional, Sanchez-Gonzalez, Laura, additional, Leijten, Jeroen, additional, Hassan, Shabir, additional, Arab-Tehrany, Elmira, additional, Ward, Jennifer Ellis, additional, and Shin, Su Ryon, additional

Published
2022
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33. From Krill to Whale: an overview of marine fatty acids and lipid compositions

Author

Linder Michel, Belhaj Nabila, Sautot Pascale, and Arab Tehrany Elmira

Subjects
fatty acids compositions, long-chain polyunsaturated fatty acids (LC-PUFA), EPA, DHA, Krill, fish roes, sharks, Oils, fats, and waxes, TP670-699
Abstract

In this study, fatty acid compositions of phyto-zooplankton (calanoid copepod species, krill…) to fish species (mackerel, sardine anchovy, salmon, shark) are presented. Marine oils are essentially used for their high long-chain polyunsaturated fatty acids (LC-PUFA), namely eicosapentaenoic (EPA) and docosahexaenoic (DHA) for their good health impact. Due to health benefits of the omega-3, weekly fish consumption is today recommended by many authorities (FDA, AFSSA…). Capture fisheries and aquaculture supplied the world with about 110 million tonnes of food fish in 2006 (FAO 2009), providing an apparent per capita supply of 16.7 kg. It is well established that the lipid composition of fish muscle is influenced by the diet and also depends on the effects of environmental factors (temperature, oxygen concentration in sea water) and endogenous medium (physiological state and individual variability). In general, cultured fish have been reported to have a softer texture than wild fish, which has been related to the differences in muscle structure, proximate composition and nutritional value. New applications of typical compounds (wax esters, squalene …) or lipid classes (glycerophospholipids, ether glycerolipids, sphingophospholipids …) as cosmetics, functional foods and dietary supplements will become very important in the near future with nano-structured drug carriers in pharmaceutical and biomedical areas.

Published
2010
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34. Comparison of the Physicochemical Properties of Chitin Extracted from Cicada orni Sloughs Harvested in Three Different Years and Characterization of the Resulting Chitosan

Author

Poerio, Aurelia, Girardet, Thomas, Petit, Chloé, Fleutot, Solenne, Jehl, Jean-Philippe, Arab-Tehrany, Elmira, Mano, João, CLEYMAND, Franck, Institut Jean Lamour (IJL), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ingénierie des Biomolécules (LIBio), Université de Lorraine (UL), Center for Research in Ceramic and Composite Materials (CICECO), Universidade de Aveiro, and ANR-15-IDEX-0004,LUE,Isite LUE(2015)

Subjects
Technology, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, QH301-705.5, Physics, QC1-999, chitin, Engineering (General). Civil engineering (General), [SPI.MAT]Engineering Sciences [physics]/Materials, Chemistry, physicochemical characterization, extraction, chitosan, TA1-2040, Biology (General), QD1-999
Abstract

Chitin and its derivative chitosan are among the most used polysaccharides for biomedical and pharmaceutical applications. Most of the commercially available chitin is obtained from seafood wastes. However, the interest in alternative renewable sources of chitin and chitosan, such as insects, is growing. When new sources are identified, their stability over time has to be evaluated to allow for their commercialization. The aim of this study is to compare the physicochemical properties of chitin extracted from Cicada orni sloughs harvested in three different years (2017, 2019 and 2020) in order to assess the stability of the source and the repeatability of the extraction process. Chitin and its derivative chitosan were characterized by simple techniques such as Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Results suggest that the physicochemical properties of the extracted chitin varied from year to year, and that these differences are not due to the extraction process, but rather to intrinsic differences within the source. We showed that these differences could already be detected by analyzing the raw material (i.e., cicada sloughs) using the above-mentioned simple methods. The chitosan obtained from deacetylation of chitin had a low degree of deacetylation (66.2±1.6%). This low degree of deacetylation can be attributed to the deacetylation process, which is probably not appropriate for this source of chitin.

Published
2021

36. Use of Active Salmon-Lecithin Nanoliposomes to Increase Polyunsaturated Fatty Acid Bioavailability in Cortical Neurons and Mice

Author

Passeri, Elodie, primary, Elkhoury, Kamil, additional, Jiménez Garavito, Maria Camila, additional, Desor, Frédéric, additional, Huguet, Marion, additional, Soligot-Hognon, Claire, additional, Linder, Michel, additional, Malaplate, Catherine, additional, Yen, Frances T., additional, and Arab-Tehrany, Elmira, additional

Published
2021
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43. Soft Nanobiomaterials (Nanoliposomes) for Biomedical Applications

Author

Elkhoury, Kamil, KAHN, Cyril J.F., Sanchez-Gonzalez, Laura, Arab-Tehrany, Elmira, KAHN, Cyril, Laboratoire d'Ingénierie des Biomolécules (LIBio), and Université de Lorraine (UL)

Subjects
[SDV.IB.BIO] Life Sciences [q-bio]/Bioengineering/Biomaterials, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, [SPI.MAT] Engineering Sciences [physics]/Materials, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials, [SDV.BIO] Life Sciences [q-bio]/Biotechnology
Abstract

International audience

Published
2021

44. Intradermal Drug Delivery: Miniaturized Needle Array‐Mediated Drug Delivery Accelerates Wound Healing (Adv. Healthcare Mater. 8/2021)

Author

Samandari, Mohamadmahdi, primary, Aghabaglou, Fariba, additional, Nuutila, Kristo, additional, Derakhshandeh, Hossein, additional, Zhang, Yuteng, additional, Endo, Yori, additional, Harris, Seth, additional, Barnum, Lindsay, additional, Kreikemeier‐Bower, Craig, additional, Arab‐Tehrany, Elmira, additional, Peppas, Nicholas A., additional, Sinha, Indranil, additional, and Tamayol, Ali, additional

Published
2021
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46. Physicochemical Properties and Liposomal Formulations of Hydrolysate Fractions of Four Sea Cucumbers (Holothuroidea: Echinodermata) from the Northwestern Algerian Coast

Author

Mecheta, Asmaa, Hanachi, Amine, Jeandel, Carole, Arab-Tehrany, Elmira, Bianchi, Arnaud, Velot, Emilie, Mezali, Karim, Linder, Michel, Abdelhamid Ibn Badis University, Ministère de l'Enseignement Supérieur et de la Recherche Scientifique [Algérie] (MESRS), Laboratoire d'Ingénierie des Biomolécules (LIBio), Université de Lorraine (UL), Ingénierie Moléculaire et Physiopathologie Articulaire (IMoPA), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), and Faculté de Pharmacie [Nancy]

Subjects
[SDV.BIO]Life Sciences [q-bio]/Biotechnology, Cell Survival, Hydrolysis, nanoliposome, Fatty Acids, Primary Cell Culture, Algerian coast, Angiotensin-Converting Enzyme Inhibitors, Mesenchymal Stem Cells, Article, peptide, lcsh:QD241-441, lcsh:Organic chemistry, Liposomes, sea cucumbers, Animals, Humans, Nanoparticles, Cells, Cultured, PUFA, ACE, phospholipids, ComputingMilieux_MISCELLANEOUS, Cell Proliferation
Abstract

To promote the nutritional and pharmacological values of four sea cucumber species (Holothuria poli, H. tubulosa, H. arguinensis, and H. sanctori), harvested from the Algerian coast, we aimed to study their proximate composition, fatty acid profile and angiotensin-converting enzyme (ACE) inhibitory activity. Their phospholipids were also used to elaborate nanoliposomes and to encapsulate peptides obtained from the same source. After the physico-chemical characterization of nanoliposomes and peptides, in vitro analyses were realized. The four holothurian species showed a high amount of protein (49.26–69.34%), and an impressive lipid profile of 27 fatty acids, mainly composed of polar fatty acids (91.16–93.85%), with a high polyunsaturated fatty acids (PUFA) content (50.90–71.80%), particularly eicosapentaenoic acid (EPA) (5.07–8.76%) and docosahexaenoic acid (DHA) (4.86–7.25%). A high phospholipids amount was also found (55.20–69.85%), mainly composed of phosphatidylcholine (PC) (51.48–58.56%). Their peptide fractions exhibited a high ACE inhibitory activity (IC50 0.30 to 0.51 mg/mL). The results also showed that the nanoliposomes do not induce cytotoxicity and cell death in human MSCs and no perturbation of proliferation for all the times and the tested concentrations, as well as the combined nanoliposomes and hydrolysates (HTS) at a concentration of 0.1 mg/mL. All four sea cucumbers show potential as a new source for omega-3, omega-6, and bioactive peptides.

Published
2020

47. Extraction and physicochemical characterization of chitin from Cicadaorni sloughs of the south-eastern French Mediterranean basin

Author

Poerio, Aurelia, Petit, Chloé, Jehl, Jean-Philippe, Arab-Tehrany, Elmira, Mano, João F., Cleymand, Franck, Institut Jean Lamour (IJL), Université de Lorraine (UL)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Ingénierie des Biomolécules (LIBio), Université de Lorraine (UL), Center for Research in Ceramic and Composite Materials (CICECO), Universidade de Aveiro, and ANR-15-IDEX-0004,LUE,Isite LUE(2015)

Subjects
lcsh:QD241-441, Cicada orni sloughs, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, lcsh:Organic chemistry, physicochemical characterization, extraction, Chitin, Extraction, chitin, Physicochemical characterization, ComputingMilieux_MISCELLANEOUS, [SPI.MAT]Engineering Sciences [physics]/Materials
Abstract

Chitin is a structural polysaccharide of the cell walls of fungi and exoskeletons of insects and crustaceans. In this study, chitin was extracted, for the first time in our knowledge, from the Cicada orni sloughs of the south-eastern French Mediterranean basin by treatment with 1 M HCl for demineralization, 1 M NaOH for deproteinization, and 1% NaClO for decolorization. The different steps of extraction were investigated by Fourier Transform Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD), Thermogravimetric Analysis (TGA), and Scanning Electron Microscopy (SEM). Results demonstrated that the extraction process was efficiently performed and that Cicada orni sloughs of the south-eastern French Mediterranean basin have a high content of chitin (42.8%) in the &alpha, form with a high degree of acetylation of 96% &plusmn, 3.4%. These results make Cicada orni of the south-eastern French Mediterranean basin a new and promising source of chitin. Furthermore, we showed that each step of the extraction present specific characteristics (for example FTIR and XRD spectra and, consequently, distinct absorbance peaks and values of crystallinity as well as defined values of maximum degradation temperatures identifiable by TGA analysis) that could be used to verify the effectiveness of the treatments, and could be favorably compared with other natural chitin sources.

Published
2020

49. Miniaturized Needle Array‐Mediated Drug Delivery Accelerates Wound Healing

Author

Samandari, Mohamadmahdi, primary, Aghabaglou, Fariba, additional, Nuutila, Kristo, additional, Derakhshandeh, Hossein, additional, Zhang, Yuteng, additional, Endo, Yori, additional, Harris, Seth, additional, Barnum, Lindsay, additional, Kreikemeier‐Bower, Craig, additional, Arab‐Tehrany, Elmira, additional, Peppas, Nicholas A., additional, Sinha, Indranil, additional, and Tamayol, Ali, additional

Published
2021
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