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Candida onychomycosis is a common fungal infection affecting the nails, primarily caused by Candida (C.) species. Regarding the increasing trend of Candida onychomycosis and the antifungal resistant phenomenon in recent years, this study aims to evaluate the epidemiological characteristics of Candida onychomycosis, the distribution of emerging species, and the antifungal susceptibility profiles of isolates. Onychomycosis caused by yeast species was confirmed through direct examination and culture of nail scraping among all individuals suspected to have onychomycosis and referred to a medical mycology laboratory between June 2019 and March 2022. Species of yeast isolates were identified using the multiplex PCR and PCR-RFLP methods. The antifungal susceptibility of isolates to common antifungal agents and imidazole drugs was evaluated according to the M-27-A3 CLSI protocol. Among 101 yeast strains isolated from onychomycosis, Candida parapsilosis complex (50.49%) was the most common species, followed by C. albicans (20.79%) and C. tropicalis (10.89%). Rare species of yeasts such as C. guilliermondii and Saccharomyces cerevisiae were also identified by molecular methods. Results obtained from antifungal susceptibility testing showed significant differences in MIC values of isoconazole, fenticonazole, and sertaconazole among different species. Overall, a fluconazole-resistant rate of 3% was found among Candida species. Moreover, there was a statistically significant difference in MICs of fenticonazole and clotrimazole between the two most prevalent causative species, C. parapsilosis complex and C. albicans. Correct identification of the causative agents of onychomycosis and performing susceptibility testing could be helpful in choosing the most appropriate antifungal therapy. [ABSTRACT FROM AUTHOR]

Figures of speech in addition to their aesthetic functions have different effects on words. Internal music is one of the effects of fiigures of speech which can play an important role in beautifying the word and its effect on the audience. The internal music comes with the use of verbal figures of speech. Figures that make words related by similarity or uniformity of vowels and consonants and create sensible alliteration. Categories of palilogy, alliteration, parallelism, pun and riming prose are among the figures of speech that play a major role in creating internal music of the poem. In this study, with a descriptive-analytical approach, we discuss the roll of music making factors in Tamhidat as an example of prose poem. The language of Ein ol-Ghozat in Tamhidat is preachy and didactical and in an addressing mode. Despite the intensity and sharpness of his speech, he speaks simple language with his audience. However, his words are in some cases melodious that influences audience and increases its penetration in the listener. The music of his words is natural so the listener can feel it with his spirit and takes its effect. Well syntagmatic arrangement of words is one of his language features that is based on music and phonemes' melody. This music gives words importance and predominance and makes Tamhida's prose a kind of prose poem. Applying some of the subtle and tiny musical elements such as parallelism (paronomasia /pun) makes the music of book more effective and catching. In other words, harmony of sounds and synchronization through which prose becomes rhythmic and melodious is one of the aesthetic aspects of the mystical prose of Ein ol-Ghozat that arises from his word's music and special intonation, so as human nature accepts it and enjoys reading. This word music is found in the form of alliteration, pun, repetition, and meter in important parts of his speech that sometimes becomes close to prosodic meter. In Ein ol-Ghozat's prose without feeling prosodic meter by listener, a wave of intonation and meter dominates resulted from alliteration and rhyme, and proximity of the number of syllables in every symmetry and perhaps likeness and nearness of the number of syllables in all or parts of the symmetries. Repetition as a key element of the internal music is one of Ein ol-Ghozat's stylistic characteristic. Repetitions are seen in three forms in Ein ol-Ghozat languages. 1-Alliteration, this group consists of various kinds of pun, rhyme, repetition, etc. 2-Parallelism: Repetition of words or phrases. 3-Palilology: Repetition of word: This form is one of the most important and aesthetic repetition in Tamhidat that in addition to making prose integrated, is effective in conveying the concept and content of the message of Ein ol-Ghozat, as repetition of the words "Alas," "O' Friend," and "O' Dear" in several phrases has a great influence in stimulation of feeling and inculcation emotion in the reader. Alliteration: One of the most important aspects of aesthetics in the mystical prose of Ein ol-Ghozat are sound harmony and alliteration that can be mainly found in pun/ paronomasia and riming. Usage of rhyme in all Tamhidat is not in the same level. Wherever discussion is didactic and reasoning, it is not generally riming, but where the subject is stories and anecdotes and analogies or becomes emotional, usually is riming. One manifestation of this figure is short sentences and aphorisms, whether the word is quotation of an old or an important person or whether the author expresses his own word. Apart from these, Ein ol-Ghozat has worked other ways to enrich his word's music. The most important of these methods are: * Bringing words that at least their initials are co-voiced. Such as: "Ebtela" and "Emtehan" * Phonemes processing: a kind of internal music is repetition and sameness of consonants and vowels. This figure in some cases, with creating a specific internal music, highlights the phrases and helps to conveying the message and gives pleasure to the audience. * Bringing together words that make a pun is another species of alliteration in the language of Ein ol-Ghozat. This figure of speech is one of the best examples of creating and enhancing music in words or sentences. * Bringing together the co-meter terms is one of other species of alliteration in Tamhidat. * Repetition of words or phrases, are of those categories that is used in the mystical prose of Ein ol-Ghozat and is one of the stylistic features and music making elements of his Word. Repetition in Ein ol-Ghozat's language, sometimes have artistic and rhetorical aspects that helps his prose being rhythmic and is effective in conveying the meaning and intention of the speaker. Ein ol-Ghozat while repeats thoughts and beliefs of the mystics, repeats words and combinations in the various types, so that he not only raises the words' musical level and makes it melodious, but also increases the rhythmic role of his own speaking. Sometimes this repetition in the form of word or phrase in the end of sentence comes symmetrically, it functions like radif in hemistiches and if in the terms of syllables number be long, makes an intonation in the words too. [ABSTRACT FROM AUTHOR]

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Background: The nasal obstruction symptom evaluation (NOSE) scale is a valid and specific questionnaire for evaluating nasal obstruction. The present study aimed to assess the validity of the Persian version of the NOSE questionnaire., Methods: The present study is a cross-sectional study conducted from December 2018 to April 2019. In the study group, eligible individuals referred to one clinic and Firoozgar Hospital, Tehran, Iran (a tertiary referral center) were asked to complete the questionnaire once on the first visit and once 3 months after the surgery. In the control group, healthy adults (above 18 years old) were selected among staff, students, residents, or relatives of the project executors. The NOSE questionnaire has 5 questions and a quality chart. The results were compared with the short form of the 12-item GHQ-12 questionnaire that had previously been translated and validated. SPSS 20 software was used to calculate Cronbach's alpha and intra-class correlation coefficient and to examine the convergent and discriminative validities., Results: The results obtained are consistent with the results of the primary research when developing the questionnaire and the results of studies conducted with different versions of the questionnaire in different languages and cultures. Analysis of research data showed that the Persian version of the NOSE questionnaire has acceptable internal consistency, repeatability, convergent validity, and discriminant validity., Conclusion: The Persian version of the NOSE questionnaire has good validity and reliability., Competing Interests: The authors declare that they have no competing interests.

Immunofluorescence is a technique that uses antibodies and fluorophores to label structures inside cells. The cells are normally fixed and permeabilized, and then structures are labelled using primary antibodies directly conjugated to fluorophores, or, more commonly, first with an antibody against an antigen of interest followed by a secondary antibody conjugated to a fluorophore that binds to the primary antibody. Fluorescence can be visualized using widefield, confocal, or super-resolution microscopy. Here we focus on labelling of the Golgi apparatus and show that different fixation and permeabilization conditions can significantly affect labelling of Golgi proteins and describe how to optimize fluorescent detection of Golgi proteins., (© 2023. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

Background: Repair of bone defects is challenging for reconstructive and orthopedic surgeons. In this study, we aimed to histomorphometrically assess new bone formation in tibial bone defects filled with octacalcium phosphate (OCP), bone matrix gelatin (BMG), and a combination of both., Methods: A total of 96 male Sprague Dawley rats aged 6-8 weeks weighing 120-150 g were randomly allocated into three experimental (OCP, BMG, and OCP/BMG) and one control group (n=24 in each group). The defects in experimental groups were filled with OCP (6 mg), BMG (6 mg), or a combination of OCP and BMG (6 mg, 2:1 ratio). No material was used to fill the defects in the control group and the defect was only covered with Surgicel. Samples were taken on days 7, 14, 21, and 56 after the surgery. The sections were stained with hematoxylin-eosin (H&E) and assessed using light microscopy., Results: In our experimental groups, bone formation was started from the margins of the defect towards the center with an increasing rate during the study period. Moreover, the formed bone was more mature. Bone formation in our control group was only limited to the margins of the defect. The newly formed bone mass was significantly higher in the experimental groups ( P=0.001 )., Conclusion: OCP, BMG, and OCP/BMG compound enhanced osteoinduction in long bones., Competing Interests: There is no Conflict of interest.