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2,237 results on '"Aránega A"'

1. The GREENBOT dataset: Multimodal mobile robotic dataset for a typical Mediterranean greenhouse

Author

Cañadas-Aránega, Fernando, Blanco-Claraco, Jose Luis, Moreno, Jose Carlos, and Rodriguez, Francisco

Subjects
Computer Science - Robotics
Abstract

This paper introduces an innovative dataset specifically crafted for challenging agricultural settings (a greenhouse), where achieving precise localization is of paramount importance. The dataset was gathered using a mobile platform equipped with a set of sensors typically used in mobile robots, as it was moved through all the corridors of a typical Mediterranean greenhouse featuring tomato crop. This dataset presents a unique opportunity for constructing detailed 3D models of plants in such indoor-like space, with potential applications such as robotized spraying. For the first time to the best knowledge of authors, a dataset suitable to put at test Simultaneous Localization and Mapping (SLAM) methods is presented in a greenhouse environment, which poses unique challenges. The suitability of the dataset for such goal is assessed by presenting SLAM results with state-of-the-art algorithms. The dataset is available online in \url{https://arm.ual.es/arm-group/dataset-greenhouse-2024/}., Comment: 29 pages, 15 figures

Published
2024
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2. A VM-Agnostic and Backwards Compatible Protected Modifier for Dynamically-Typed Languages

Author

Thomas, Iona, Aranega, Vincent, Ducasse, Stéphane, Polito, Guillermo, and Tesone, Pablo

Subjects
Computer Science - Programming Languages
Abstract

In object-oriented languages, method visibility modifiers hold a key role in separating internal methods from the public API. Protected visibility modifiers offer a way to hide methods from external objects while authorizing internal use and overriding in subclasses. While present in main statically-typed languages, visibility modifiers are not as common or mature in dynamically-typed languages. In this article, we present ProtDyn, a self-send-based visibility model calculated at compile time for dynamically-typed languages relying on name-mangling and syntactic differentiation of self vs non self sends. We present #Pharo, a ProtDyn implementation of this model that is backwards compatible with existing programs, and its port to Python. Using these implementations we study the performance impact of ProtDyn on the method lookup, in the presence of global lookup caches and polymorphic inline caches. We show that our name mangling and double method registration technique has a very low impact on performance and keeps the benefits from the global lookup cache and polymorphic inline cache. We also show that the memory overhead on a real use case is between 2% and 13% in the worst-case scenario. Protected modifier semantics enforces encapsulation such as private but allow developers to still extend the class in subclasses. ProtDyn offers a VM-agnostic and backwards-compatible design to introduce protected semantics in dynamically-typed languages.

Published
2023
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5. MultiVehicle Simulator (MVSim): lightweight dynamics simulator for multiagents and mobile robotics research

Author

Blanco-Claraco, José-Luis, Tymchenko, Borys, Mañas-Alvarez, Francisco José, Cañadas-Aránega, Fernando, López-Gázquez, Ángel, and Moreno, José Carlos

Subjects
Computer Science - Robotics, Computer Science - Multiagent Systems
Abstract

Development of applications related to closed-loop control requires either testing on the field or on a realistic simulator, with the latter being more convenient, inexpensive, safe, and leading to shorter development cycles. To address that need, the present work introduces MVSim, a simulator for multiple vehicles or robots capable of running dozens of agents in simple scenarios, or a handful of them in complex scenarios. MVSim employs realistic physics-grounded friction models for tire-ground interaction, and aims at accurate and GPU-accelerated simulation of most common modern sensors employed in mobile robotics and autonomous vehicle research, such as depth and RGB cameras, or 2D and 3D LiDAR scanners. All depth-related sensors are able to accurately measure distances to 3D models provided by the user to define custom world elements. Efficient simulation is achieved by means of focusing on ground vehicles, which allows the use of a simplified 2D physics engine for body collisions while solving wheel-ground interaction forces separately. The core parts of the system are written in C++ for maximum efficiency, while Python, ROS 1, and ROS 2 wrappers are also offered for easy integration into user systems. A custom publish/subscribe protocol based on ZeroMQ (ZMQ) is defined to allow for multiprocess applications to access or modify a running simulation. This simulator enables and makes easier to do research and development on vehicular dynamics, autonomous navigation algorithms, and simultaneous localization and mapping (SLAM) methods., Comment: 6 pages, 6 figures, submitted

Published
2023
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6. Impact of digitalization and innovation in women's entrepreneurial orientation on sustainable start-up intention

Author

Shatila Khodor, Alba Yela Aránega, and Veland Ramadani

Subjects
Entrepreneurial orientation, Women entrepreneurs, Digitalization, Sustainable start-up, Lebanese, Technology, Business, HF5001-6182
Abstract

This study explores the complex dynamics between Lebanese women entrepreneurs' Entrepreneurial Orientation (EO) and their propensity to launch new sustainable businesses by examining the mediating function of dynamic capabilities and the moderating influence of digitalization. Dynamic Capabilities are expected to be a crucial mechanism through which entrepreneurship orientation positively affects sustainable start-up intentions. A total of 351 Lebanese women entrepreneurs were carefully chosen to serve as the research sample. The present study used structural equation modeling (SEM), which permits a systematic examination of the interaction between the constructs, to investigate the correlations and dynamics between the variables. The findings of this research have practical implications for policymakers, business support entrepreneurs, and aspiring women entrepreneurs in Lebanon. Understanding the underlying mechanisms that drive start-up intentions among Lebanese women entrepreneurs can inform the design and implementation of targeted interventions and support mechanisms that promote entrepreneurship and innovation in the sustainable development. This article illustrates and explains how dynamic capabilities mediate the relationship between women's entrepreneurial orientation and entrepreneurial sustainable start-up intention and how digitalization moderates the relationship between innovation and entrepreneurial start-up intention in the Lebanese context.

Published
2024
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7. Challenged global economics amid conflict in warring countries

Author

Ana Tsutsunashvili, Alba Yela Aránega, and Raúl Castaño Urueña

Subjects
Economy, Investment, Regional development, Blockade, Social threats, Technology, Business, HF5001-6182
Abstract

This research delves into the multifaceted challenges posed to society and regional development in the wake of Russia's invasion of Ukraine, with a specific focus on the period spanning from February 2022 to February 2023 as a response to the social and entrepreneurial threats that have appeared due to the conflict. In addition, this research seeks not only to alleviate prevailing uncertainties but also to facilitate a comprehensive understanding of the economic landscape by identifying causal factors and providing a relevant contextual framework for the threats to society and regional development in the aftermath of Russia's invasion of Ukraine, which affects sustainability both economically and socially. These disruptions have given rise to unprecedented uncertainties that could potentially trigger an irreversible cascade of shortages, leading to escalating costs of critical or irreplaceable products that directly affect regional development. This paper scrutinizes this intricate process, aiming to discern underlying patterns and mitigate the prevailing uncertainty—a state that challenges rational decision-making. In this pursuit, established economic theories are deployed to provide comprehensive insights into the evolving reality. Through an in-depth analysis of the interplay between the Covid-19 pandemic, the ensuing economic crisis, and the ramifications of the Ukraine-Russia conflict, this research reveals a stark decline in economic growth. In addition, the present study explores potential solutions, emphasizing the importance of enhancing workforce skills through meticulously designed educational strategies and promoting gender diversity in science, technology, engineering and mathematics (STEM) programs.

Published
2024
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8. 5-Fluorouracil-loaded poly(ε-caprolactone) nanoparticles combined with phage E gene therapy as a new strategy against colon cancer

Author

Ortiz R, Prados J, Melguizo C, Arias JL, Ruíz MA, Álvarez PJ, Caba O, Luque R, Segura A, and Aránega A

Subjects
Medicine (General), R5-920
Abstract

Raúl Ortiz1,3, José Prados1, Consolación Melguizo1, José L Arias2, M Adolfina Ruiz2, Pablo J Álvarez1, Octavio Caba1,3, Raquel Luque4, Ana Segura5, Antonia Aránega11Institute of Biopathology and Regenerative Medicine (IBIMER), 2Department of Pharmacy and Pharmaceutical Technology, University of Granada, Granada, Spain; 3Department of Health Science, University of Jaén, Jaén, Spain; 4Service of Medical Oncology, Virgen de las Nieves Hospital, Granada, Spain; 5CSIC-Estacion Experimental del Zaidin, Department of Environmental Protection, Granada, SpainAbstract: This work aimed to develop a new therapeutic approach to increase the efficacy of 5-fluorouracil (5-FU) in the treatment of advanced or recurrent colon cancer. 5-FU-loaded biodegradable poly(ε-caprolactone) nanoparticles (PCL NPs) were combined with the cytotoxic suicide gene E (combined therapy). The SW480 human cancer cell line was used to assay the combined therapeutic strategy. This cell line was established from a primary adenocarcinoma of the colon and is characterized by an intrinsically high resistance to apoptosis that correlates with its resistance to 5-FU. 5-FU was absorbed into the matrix of the PCL NPs during synthesis using the interfacial polymer disposition method. The antitumor activity of gene E from the phage ΦX174 was tested by generating a stable clone (SW480/12/E). In addition, the localization of E protein and its activity in mitochondria were analyzed. We found that the incorporation of 5-FU into PCL NPs (which show no cytotoxicity alone), significantly improved the drug's anticancer activity, reducing the proliferation rate of colon cancer cells by up to 40-fold when compared with the nonincorporated drug alone. Furthermore, E gene expression sensitized colon cancer cells to the cytotoxic action of the 5-FU-based nanomedicine. Our findings demonstrate that despite the inherent resistance of SW480 to apoptosis, E gene activity is mediated by an apoptotic phenomenon that includes modulation of caspase-9 and caspase-3 expression and intense mitochondrial damage. Finally, a strongly synergistic antiproliferative effect was observed in colon cancer cells when E gene expression was combined with the activity of the 5-FU-loaded PCL NPs, thereby indicating the potential therapeutic value of the combined therapy.Keywords: colon cancer, combined therapy, 5-fluorouracil, gene therapy, E gene, poly (ε-caprolactone)

Published
2012

9. Posttranscriptional Regulation by Proteins and Noncoding RNAs

Author

Aranega, Amelia E., Franco, Diego, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, Rickert-Sperling, Silke, editor, Kelly, Robert G., editor, and Haas, Nikolaus, editor

Published
2024
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15. Towards a Smart Data Processing and Storage Model

Author

Salgado, Ronie, Denker, Marcus, Ducasse, Stéphane, Etien, Anne, and Aranega, Vincent

Subjects
Computer Science - Computation and Language, Computer Science - Programming Languages, Computer Science - Software Engineering
Abstract

In several domains it is crucial to store and manipulate data whose origin needs to be completely traceable to guarantee the consistency, trustworthiness and reliability on the data itself typically for ethical and legal reasons. It is also important to guarantee that such properties are also carried further when such data is composed and processed into new data. In this article we present the main requirements and theorethical problems that arise by the design of a system supporting data with such capabilities. We present an architecture for implementing a system as well as a prototype developed in Pharo.

Published
2021

19. miR-1 as a Key Epigenetic Regulator in Early Differentiation of Cardiac Sinoatrial Region

Author

Carlos García-Padilla, Estefanía Lozano-Velasco, Virginio García-López, Amelia Aránega, Diego Franco, Virginio García-Martínez, and Carmen López-Sánchez

Subjects
miR-1, epigenetic regulator, cardiac sinoatrial region, molecular mechanisms, Hdac4, Calm1/Calmodulin, Biology (General), QH301-705.5, Chemistry, QD1-999
Abstract

A large diversity of epigenetic factors, such as microRNAs and histones modifications, are known to be capable of regulating gene expression without altering DNA sequence itself. In particular, miR-1 is considered the first essential microRNA in cardiac development. In this study, miR-1 potential role in early cardiac chamber differentiation was analyzed through specific signaling pathways. For this, we performed in chick embryos functional experiments by means of miR-1 microinjections into the posterior cardiac precursors—of both primitive endocardial tubes—committed to sinoatrial region fates. Subsequently, embryos were subjected to whole mount in situ hybridization, immunohistochemistry and RT-qPCR analysis. As a relevant novelty, our results revealed that miR-1 increased Amhc1, Tbx5 and Gata4, while this microRNA diminished Mef2c and Cripto expressions during early differentiation of the cardiac sinoatrial region. Furthermore, we observed in this developmental context that miR-1 upregulated CrabpII and Rarß and downregulated CrabpI, which are three crucial factors in the retinoic acid signaling pathway. Interestingly, we also noticed that miR-1 directly interacted with Hdac4 and Calm1/Calmodulin, as well as with Erk2/Mapk1, which are three key factors actively involved in Mef2c regulation. Our study shows, for the first time, a key role of miR-1 as an epigenetic regulator in the early differentiation of the cardiac sinoatrial region through orchestrating opposite actions between retinoic acid and Mef2c, fundamental to properly assign cardiac cells to their respective heart chambers. A better understanding of those molecular mechanisms modulated by miR-1 will definitely help in fields applied to therapy and cardiac regeneration and repair.

Published
2024
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22. Sub-method, partial behavioral reflection with Reflectivity: Looking back on 10 years of use

Author

Costiou, Steven, Aranega, Vincent, and Denker, Marcus

Subjects
Computer Science - Programming Languages
Abstract

Context. Refining or altering existing behavior is the daily work of every developer, but that cannot be always anticipated, and software sometimes cannot be stopped. In such cases, unanticipated adaptation of running systems is of interest for many scenarios, ranging from functional upgrades to on-the-fly debugging or monitoring of critical applications. Inquiry. A way of altering software at run time is using behavioral reflection, which is particularly well-suited for unanticipated adaptation of real-world systems. Partial behavioral reflection is not a new idea, and for years many efforts have been made to propose a practical way of expressing it. All these efforts resulted in practical solutions, but which introduced a semantic gap between the code that requires adaptation and the expression of the partial behavior. For example, in Aspect-Oriented Programming, a pointcut description is expressed in another language, which introduces a new distance between the behavior expression (the Advice) and the source code in itself. Approach. Ten years ago, the idea of closing the gap between the code and the expression of the partial behavior led to the implementation of the Reflectivity framework. Using Reflectivity, developers annotate Abstract Syntax Tree (AST) nodes with meta-behavior which is taken into account by the compiler to produce behavioral variations. In this paper, we present Reflectivity, its API, its implementation and its usage in Pharo. We reflect on ten years of use of Reflectivity, and show how it has been used as a basic building block of many innovative ideas. Knowledge. Reflectivity brings a practical way of working at the AST level, which is a high-level representation of the source code manipulated by software developers. It enables a powerful way of dynamically add and modify behavior. Reflectivity is also a flexible mean to bridge the gap between the expression of the meta-behavior and the source code. This ability to apply unanticipated adaptation and to provide behavioral reflection led to many experiments and projects during this last decade by external users. Existing work use Reflectivity to implement reflective libraries or languages extensions, featherweight code instrumentation, dynamic software update, debugging tools and visualization and software analysis tools. Grounding. Reflectivity is actively used in research projects. During the past ten years, it served as a support, either for implementation or as a fundamental base, for many research work including PhD theses, conference, journal and workshop papers. Reflectivity is now an important library of the Pharo language, and is integrated at the heart of the platform. Importance. Reflectivity exposes powerful abstractions to deal with partial behavioral adaptation, while providing a mature framework for unanticipated, non-intrusive and partial behavioral reflection based on AST annotation. Furthermore, even if Reflectivity found its home inside Pharo, it is not a pure Smalltalk-oriented solution. As validation over the practical use of Reflectivity in dynamic object-oriented languages, the API has been ported to Python. Finally, the AST annotation feature of Reflectivity opens new experimentation opportunities about the control that developers could gain on the behavior of their own software.

Published
2020
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23. MGMT promoter methylation status and MGMT and CD133 immunohistochemical expression as prognostic markers in glioblastoma patients treated with temozolomide plus radiotherapy

Author

Melguizo Consolación, Prados Jose, González Beatriz, Ortiz Raul, Concha Angel, Alvarez Pablo, Madeddu Roberto, Perazzoli Gloria, Oliver Jaime, López Rodrigo, Rodríguez-Serrano Fernando, and Aránega Antonia

Subjects
Glioblastoma, Radiotherapy, Temozolomide, MGMT, Methylation, CD133, Medicine
Abstract

Abstract Background The CD133 antigen is a marker of radio- and chemo-resistant stem cell populations in glioblastoma (GBM). The O6-methylguanine DNA methyltransferase (MGMT) enzyme is related with temozolomide (TMZ) resistance. Our propose is to analyze the prognostic significance of the CD133 antigen and promoter methylation and protein expression of MGMT in a homogenous group of GBM patients uniformly treated with radiotherapy and TMZ. The possible connection between these GBM markers was also investigated. Methods Seventy-eight patients with GBM treated with radiotherapy combined with concomitant and adjuvant TMZ were analyzed for MGMT and CD133. MGMT gene promoter methylation was determined by methylation-specific polymerase chain reaction after bisulfite treatment. MGMT and CD133 expression was assessed immunohistochemically using an automatic quantification system. Overall and progression-free survival was calculated according to the Kaplan–Meier method. Results The MGMT gene promoter was found to be methylated in 34 patients (44.7%) and unmethylated in 42 patients (55.3%). A significant correlation was observed between MGMT promoter methylation and patients’ survival. Among the unmethylated tumors, 52.4% showed low expression of MGMT and 47.6% showed high-expression. Among methylated tumors, 58.8% showed low-expression of MGMT and 41.2% showed high-expression. No correlation was found between MGMT promoter methylation and MGMT expression, or MGMT expression and survival. In contrast with recent results, CD133 expression was not a predictive marker in GBM patients. Analyses of possible correlation between CD133 expression and MGMT protein expression or MGMT promoter methylation were negative. Conclusions Our results support the hypothesis that MGMT promoter methylation status but not MGMT expression may be a predictive biomarker in the treatment of patients with GBM. In addition, CD133 should not be used for prognostic evaluation of these patients. Future studies will be necessary to determine its clinical utility.

Published
2012
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24. Dermatomyositis unleashed by immune checkpoint inhibitors. Three additional cases and a review of the literature

Author

Guerra, Néstor López, Matas-García, Ana, Serra-García, Laura, Morgado-Carrasco, Daniel, Padrosa, Joan, Aldecoa, Iban, Duque, Yaiza, Casal-Dominguez, Maria, Muñoz-Braceras, Sandra, Aranega, Raquel, Moreno-Lozano, Pedro, Cantó-Santos, Judith, Garrabou, Glòria, Ruiz-Ortiz, Estíbaliz, Trallero-Araguas, Ernesto, Selva-O'Callaghan, Albert, Grau, Josep M., Puig, Susana, Torres-Ruiz, Jiram, Mammen, Andrew L., Fernandez, Iago Pinal, and Milisenda, José C.

Published
2023
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25. Multimodal Mobile Robotic Dataset for a Typical Mediterranean Greenhouse: The GREENBOT Dataset

Author

Fernando Cañadas-Aránega, Jose Luis Blanco-Claraco, Jose Carlos Moreno, and Francisco Rodriguez-Diaz

Subjects
dataset, LiDAR, stereo vision, SLAM, ROS, Chemical technology, TP1-1185
Abstract

This paper presents an innovative dataset designed explicitly for challenging agricultural environments, such as greenhouses, where precise location is crucial, but GNNS accuracy may be compromised by construction elements and the crop. The dataset was collected using a mobile platform equipped with a set of sensors typically used in mobile robots as it was moved through all the corridors of a typical Mediterranean greenhouse featuring tomato crops. This dataset presents a unique opportunity for constructing detailed 3D models of plants in such indoor-like spaces, with potential applications such as robotized spraying. For the first time, to the authors’ knowledge, a dataset suitable to test simultaneous localization and mapping (SLAM) methods is presented in a greenhouse environment, which poses unique challenges. The suitability of the dataset for this purpose is assessed by presenting SLAM results with state-of-the-art algorithms. The dataset is available online.

Published
2024
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26. Sindarin: A Versatile Scripting API for the Pharo Debugger

Author

Dupriez, Thomas, Polito, Guillermo, Costiou, Steven, Aranega, Vincent, and Ducasse, Stéphane

Subjects
Computer Science - Programming Languages, Computer Science - Software Engineering
Abstract

Debugging is one of the most important and time consuming activities in software maintenance, yet mainstream debuggers are not well-adapted to several debugging scenarios. This has led to the research of new techniques covering specific families of complex bugs. Notably, recent research proposes to empower developers with scripting DSLs, plugin-based and moldable debuggers. However, these solutions are tailored to specific use-cases, or too costly for one-time-use scenarios. In this paper we argue that exposing a debugging scripting interface in mainstream debuggers helps in solving many challenging debugging scenarios. For this purpose, we present Sindarin, a scripting API that eases the expression and automation of different strategies developers pursue during their debugging sessions. Sindarin provides a GDB-like API, augmented with AST-bytecode-source code mappings and object-centric capabilities. To demonstrate the versatility of Sindarin, we reproduce several advanced breakpoints and non-trivial debugging mechanisms from the literature.

Published
2019

33. Development of in vitro and in vivo tools to evaluate the antiangiogenic potential of melatonin to neutralize the angiogenic effects of VEGF and breast cancer cells: CAM assay and 3D endothelial cell spheroids

Author

Laborda-Illanes, Aurora, Sánchez-Alcoholado, Lidia, Castellano-Castillo, Daniel, Boutriq, Soukaina, Plaza-Andrades, Isaac, Aranega-Martín, Lucía, Peralta-Linero, Jesús, Alba, Emilio, González-González, Alicia, and Queipo-Ortuño, María Isabel

Published
2023
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36. MultiVehicle Simulator (MVSim): Lightweight dynamics simulator for multiagents and mobile robotics research

Author

José-Luis Blanco-Claraco, Borys Tymchenko, Francisco José Mañas-Alvarez, Fernando Cañadas-Aránega, Ángel López-Gázquez, and José Carlos Moreno

Subjects
Mobile robotics, Vehicle dynamics, Vehicle–ground interaction, Multi-agent simulation, Computer software, QA76.75-76.765
Abstract

Development of applications related to closed-loop control requires either testing on the field or on a realistic simulator, with the latter being more convenient. To ease that need, this work introduces MVSim, a simulator for multiple vehicles or robots capable of running in real time dozens of agents in simple scenarios, or a handful of them in complex scenarios. MVSim employs realistic physics-grounded friction models for tire–ground interaction, and aims at accurate and GPU-accelerated simulation of most common modern sensors employed in mobile robotics and autonomous vehicle research, such as depth and RGB cameras, or 2D and 3D LiDAR scanners. All depth-related sensors are able to accurately measure distances to 3D models provided by the user to define custom world elements. Efficient simulation is achieved by means of focusing on ground vehicles, which allows the use of a simplified 2D physics engine for body collisions while solving wheel–ground interaction forces separately. The core parts of the system are written in C++ for maximum efficiency, while Python, ROS 1, and ROS 2 wrappers are also offered. A custom publish/subscribe protocol based on ZeroMQ (ZMQ) is defined to allow for multiprocess applications to access or modify a running simulation. This simulator enables and makes easier to do research and development on vehicular dynamics, autonomous navigation algorithms, and simultaneous localization and mapping (SLAM) methods. An experimental performance benchmarking is provided against other state-of-the-art simulators showing significant less CPU usage. The project source code is freely available online under the BSD 3-clause license in https://github.com/MRPT/mvsim.

Published
2023
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41. Understanding Epicardial Cell Heterogeneity during Cardiogenesis and Heart Regeneration

Author

Cristina Sanchez-Fernandez, Lara Rodriguez-Outeiriño, Lidia Matias-Valiente, Felicitas Ramírez de Acuña, Diego Franco, and Amelia Eva Aránega

Subjects
epicardium, heterogeneity, cardiac development, cardiac repair, Diseases of the circulatory (Cardiovascular) system, RC666-701
Abstract

The outermost layer of the heart, the epicardium, is an essential cell population that contributes, through epithelial-to-mesenchymal transition (EMT), to the formation of different cell types and provides paracrine signals to the developing heart. Despite its quiescent state during adulthood, the adult epicardium reactivates and recapitulates many aspects of embryonic cardiogenesis in response to cardiac injury, thereby supporting cardiac tissue remodeling. Thus, the epicardium has been considered a crucial source of cell progenitors that offers an important contribution to cardiac development and injured hearts. Although several studies have provided evidence regarding cell fate determination in the epicardium, to date, it is unclear whether epicardium-derived cells (EPDCs) come from specific, and predetermined, epicardial cell subpopulations or if they are derived from a common progenitor. In recent years, different approaches have been used to study cell heterogeneity within the epicardial layer using different experimental models. However, the data generated are still insufficient with respect to revealing the complexity of this epithelial layer. In this review, we summarize the previous works documenting the cellular composition, molecular signatures, and diversity within the developing and adult epicardium.

Published
2023
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42. Integrated Multi-Omics Analysis for Inferring Molecular Players in Inclusion Body Myositis

Author

Judith Cantó-Santos, Laura Valls-Roca, Ester Tobías, Clara Oliva, Francesc Josep García-García, Mariona Guitart-Mampel, Félix Andújar-Sánchez, Anna Esteve-Codina, Beatriz Martín-Mur, Joan Padrosa, Raquel Aránega, Pedro J. Moreno-Lozano, José César Milisenda, Rafael Artuch, Josep M. Grau-Junyent, and Glòria Garrabou

Subjects
inclusion body myositis (IBM), metabolism, organic acids, nucleotides, biomarker, Therapeutics. Pharmacology, RM1-950
Abstract

Inclusion body myositis (IBM) is an acquired inflammatory myopathy affecting proximal and distal muscles that leads to weakness in patients over 50. It is diagnosed based on clinical and histological findings in muscle related to inflammation, degeneration, and mitochondria. In relation to IBM, a shortage of validated disease models and a lack of biomarkers and effective treatments constitute an unmet medical need. To overcome these hurdles, we performed an omics analysis of multiple samples from IBM patients (saliva, fibroblasts, urine, plasma, and muscle) to gain insight into the pathophysiology of IBM. Degeneration was evident due to the presence of amyloid β peptide 1–42 (Aβ1–42) in the saliva of the analyzed IBM patients. The presence of metabolic disarrangements in IBM was indicated by an imbalanced organic acid profile in fibroblasts and urine. Specifically, abnormal levels of L-pyroglutamic and orotic acid were supported by the abnormal expression of related metabolites in plasma and urine (glutathione and pyrimidines) and the aberrant expression of upstream gene regulators (L2HGDH, IDH2, OPLAH, and ASL) in muscle. Combined levels of L-pyroglutamic and orotic acid displayed an outstanding biomarker signature in urine with 100% sensitivity and specificity. The confirmation of systemic metabolic disarrangements in IBM and the identification of novel biomarkers reported herein unveil novel insights that require validation in larger cohorts.

Published
2023
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43. Tratamiento renal sustitutivo con diálisis en el paciente diabético

Author

Marina Blanco-García, Susana Aránega-Gavilán, Irene Guillén-Gómez, and Rodolfo Crespo-Montero

Subjects
tratamiento renal sustitutivo, diabetes mellitus, nefropatía diabética, hemodiálisis, diálisis peritoneal, Nursing, RT1-120, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Introducción: La nefropatía diabética es una de las complicaciones más importantes de la diabetes. Su desarrollo va desde estadios iniciales, hasta insuficiencia renal crónica terminal, requiriendo la entrada en un programa de tratamiento renal sustitutivo. Objetivos: Conocer y sintetizar la evidencia científica sobre el tratamiento renal sustitutivo con diálisis en el paciente diabético. Metodología: Se llevó a cabo una revisión integrativa siguiendo las recomendaciones de la declaración PRISMA, en las bases de datos PubMed y Scielo. La estrategia de búsqueda se estableció con los siguientes términos MeSH: ‘’Diabetes Mellitus’’, ‘’Renal Dialysis’’, ‘’Hemodialysis’’, ‘’Kidney diseases’’, ‘’Renal replacement therapy’’, ‘’Kidney treatment’’, ‘’Diabetic foot’’. Resultados: Se seleccionaron 22 artículos. De ellos, 17 fueron revisiones sistemáticas, 1 guía de práctica clínica, 1 estudio descriptivo transversal, 1 estudio observacional analítico, y 2 capítulos de libro. De la revisión emergieron las siguientes variables: tipo de diabetes, edad, evolución, tipo de tratamiento renal sustitutivo, pie diabético y prevención. Conclusiones: Se observa una gran heterogeneidad en la evolución de la nefropatía diabética. Por lo tanto, determinar el tratamiento renal sustitutivo para el paciente diabético se convierte en un desafío. El manejo del pie diabético, como principal complicación de estos pacientes, se centra en la prevención, apoyada por una buena educación. La prevalencia de la nefropatía diabética va en aumento, por lo que una mejora en la estrategia de prevención de la enfermedad podría cambiar el curso de la misma.

Published
2022
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46. Non-coding RNAs and Atrial Fibrillation

Author

Franco, Diego, Aranega, Amelia, Dominguez, Jorge N., Crusio, Wim E., Series Editor, Lambris, John D., Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, and Xiao, Junjie, editor

Published
2020
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48. Alteraciones neoplásicas en el paciente trasplantado renal. Una revisión sistemática

Author

Irene Guillén-Gómez, Marina Blanco-García, Susana Aránega-Gavilán, and Rodolfo Crespo-Montero

Subjects
neoplasias, trasplante de riñón, incidencia, factores de riesgo, Nursing, RT1-120, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Introducción: El trasplante renal se ha destacado como la mejor terapia renal sustitutiva para la enfermedad renal crónica terminal, aunque conlleva una serie de riesgos entre los que el cáncer se destaca cada vez más, por lo que parece importante determinar el impacto que tiene en esta población. Objetivo: Conocer y sintetizar la evidencia científica acerca de la incidencia de neoplasias en pacientes trasplantados renales, así como las variables relacionadas con las mismas. Metodología: Se realizó una revisión sistemática en la que se incluyeron 14 artículos procedentes de las bases de Pubmed, Scopus, Scielo, WOS y Google Académico. Como términos MeSH se utilizaron: neoplasias (neoplasms), trasplante de riñón (kidney transplantation), incidencia (incidence), riesgo (risk), factores de riesgo (risk factors). Se incluyeron artículos originales en inglés y español, en población trasplantada adulta. Resultados: Se incluyeron 14 artículos de diseño observacional. De la revisión emergieron como principales variables: incidencia general, datos demográficos y tratamientos previos, otras características asociadas, tumores más frecuentes y medidas preventivas. Conclusiones: La incidencia de neoplasias en el paciente trasplantado es alta, sobre todo en la edad avanzada y pacientes con tratamiento inmunosupresor con ciclosporina y azatioprina siendo este último, junto al trasplante procedente de cadáver, los principales factores de riesgo encontrados. Los cánceres de piel no melanoma son los más prevalentes y como medidas de prevención se destaca llevar a cabo un cribado rutinario, fomento de una vida saludable, y promoción y potenciación de la vacunación de la hepatitis B.

Published
2022
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49. Aspectos psicosociales del paciente en diálisis. Una revisión bibliográfica

Author

Susana Aránega-Gavilán, Irene Guillén-Gómez, Marina Blanco-García, and Rodolfo Crespo-Montero

Subjects
diálisis, hemodiálisis, factores psicosociales, calidad de vida, Nursing, RT1-120, Diseases of the genitourinary system. Urology, RC870-923
Abstract

Introducción: La enfermedad renal crónica es una patología progresiva e infradiagnosticada en sus primeros estadios y que va a necesitar un tratamiento renal sustitutivo en estadios avanzados, siendo el más utilizado la diálisis. Esto va a provocar un fuerte impacto en el bienestar psicosocial de los pacientes, con repercusión en su calidad de vida. Objetivo: Conocer la evidencia científica existente acerca de los factores psicosociales asociados a los pacientes sometidos a diálisis. Metodología: Se realizó una revisión bibliográfica sistematizada basada en la declaración PRISMA, en las bases de datos Pubmed, Proquest y Scielo. Para ello, se utilizaron una serie de estrategias de búsqueda en las que se utilizaron los siguientes términos Mesh: “Hemodyalisis”, “Peritoneal dyalisis”, “Factors psychosocial”, “Psychosocial cares”. La búsqueda se restringió a 5 años. Resultados: Se seleccionaron 28 artículos. Todos fueron de diseño observacional descriptivo, menos un ensayo controlado aleatorizado. De esta revisión emergieron como variables importantes: alteración del estado emocional, afrontamiento, situación laboral, depresión y ansiedad, apoyo social y calidad de vida relacionada con la salud. Conclusiones: Los principales aspectos psicosociales asociados a los pacientes en diálisis fueron la depresión y ansiedad, el apoyo social, la alteración del estado emocional, situación laboral y afrontamiento; siendo los más prevalentes la depresión y la ansiedad. La situación laboral y la depresión y ansiedad, se relacionan con una peor calidad de vida, mientras que la presencia de apoyo social y el estilo de afrontamiento de “evitación” mejoran la calidad de vida de estos pacientes.

Published
2022
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50. Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19: a multicentre cohort study

Author

Aznar Muñoz, Esther, Gil Divasson, Pedro, González Muñiz, Patricia, Muñoz Aguirre, Clara, Retamar, Pilar, Valiente, Adoración, López-Cortés, Luis E., Sojo-Dorado, Jesús, Bravo-Ferrer, José, Salamanca, Elena, Palacios-Baena, Zaira R., Pérez-Palacios, Patricia, Gandullo-Moro, María, Ruíz-Hueso, Rocío, Moya-González, Natalia, Valido-Morales, Agustín, Pavón-Masa, María, Díaz Menéndez, Marta, De la Calle Prieto, Fernando, Arsuaga Vicente, Marta, Trigo Esteban, Elena, De Miguel Buckley, Rosa, Cadiñanos Loidi, Julen, Busca Arenzana, Carmen, Mican Rivera, Rafael, Mora Rillo, Marta, Loeches Yagüe, Belén, Bernardino de la Serna, José Ignacio, García Rodríguez, Julio, Montejano Sánchez, Rocío, Diaz Pollan, Beatriz, López, Juan Carlos, Ramírez-Schacke, Margarita, Gutiérrez, Isabel, Tejerina, Francisco, Aldámiz-Echevarría, Teresa, Díez, Cristina, Fanciulli, Chiara, Pérez-Latorre, Leire, Parras, Francisco, Catalán, Pilar, García-Leoni, María E, Pérez-Tamayo, Isabel, Puente, Luis, Cedeño, Jamil, Such-Diaz, Ana, Álvaro-Alonso, Elena, Izquierdo-García, Elsa, Torres-Macho, Juan, Cuevas, Guillermo, Notario, Helena, Mestre-Gómez, Beatriz, Jiménez-González de Buitrago, Eva, Fernández-Jiménez, Inés, Tebar-Martínez, Ana Josefa, Brañas, Fátima, Valencia, Jorge, Pérez-Butragueño, Mario, Alvarado, Marta, Abelenda-Alonso, Gabriela, Ardanuy, Carmen, Bergas, Alba, Cuervo, Guillermo, Domínguez, María Ángeles, Fernández-Huerta, Miguel, Gudiol, Carlota, Lorenzo-Esteller, Laia, Niubó, Jordi, Pérez-Recio, Sandra, Podzamczer, Daniel, Pujol, Miquel, Rombauts, Alexander, Trullen, Núria, Cisneros, José Miguel, Amodeo, Cristina, Camacho, Pedro, Espinosa, Nuria, García-Gutiérrez, Manuel, Jara-Palomares, Luis, González-León, Rocío, Molina, José, Nieto Martín, María Dolores, Paniagua, María, Poyato, Manuel, Rodríguez-Villodres, Ángel, Ruiz de Azua, Zaida, Salamanca, Celia, Sepúlveda Berrocal, Mº Antonia, Yera Bergua, Carmen, Toledano Sierra, Pilar, Cano Llorente, Verónica, Zafar Iqubal-Mirza, Sadaf, Muñiz, Gema, Martín Pérez, Inmaculada, Mozas Moriñigo, Helena, Alguacil, Ana, García Butenegro, María Paz, Peláez Ballesta, Ana Isabel, Morcillo Rodríguez, Elena, Goikoetxea Agirre, Josune, Blanco Vidal, María José, Nieto Arana, Javier, del Álamo Martínez de Lagos, Mikel, Pérez Hernández, Isabel A., Pérez Zapata, Inés, Silvariño Fernández, Rafael, Ugalde Espiñeira, Jon, Rivas-Carmenado, María, Suárez Pérez, Lucia, Suárez Diaz, Silvia, Yllera Gutiérrez, Carmen, Boix, Vicente, Díez Martínez, Marcos, Carreres Candela, Melissa, Gómez-Ayerbe, Cristina, Sánchez-Lora, Javier, Velasco Garrido, José Luis, López-Jodar, María, Santos González, Jesús, Ruiz Aragón, Jesús, Virto Peña, Ianire, Alende Castro, Vanessa, Sande Llovo, Diana, Vega Molpeceres, Sonia, Pons Viñas, Estel, del Río Pérez, Oscar, Valero Rovira, Silvia, Villar-García, Judit, Gómez-Junyent, Joan, Cánepa, María Cecilia, Castañeda Espinosa, Silvia, Letang, Emilio, Arenas-Miras, María del Mar, Gómez-Zorrilla, Silvia, Sánchez Martínez, Francesca, Lerma-Chippirraz, Elisabet, García Vázquez, Elisa, Moral Escudero, Encarnación, Roura Piloto, Aychel Elena, García Almodóvar, Esther, Sáez Barberá, Carmen, Karroud, Zineb, Hernández Quero, José, Vinuesa García, David, García Fogeda, José Luis, Peregrina, José Antonio, Novella Mena, María, Hernández Gutiérrez, Cristina, Sanz Moreno, José, Pérez Tanoira, Ramón, Navarro López, Jorge, Balsa Vázquez, Javier, Gutiérrez García, Aida, Arranz Caso, Alberto, Cuadros González, Juan, Álvarez de Mon Soto, Melchor, Díaz De Brito Fernández, Vicente Ferrer, Sanmarti Vilamala, Montserrat, Gabarrell Pascuet, Aina, Molina Morant, Daniel, España Cueto, Sergio, Cámara Fernández, Jonathan, Sabater Gil, Albert, Muñoz López, Laura, Jorge García, Ruth, Molina Torres, Nora, Sempere Alcocer, Marco Antonio, De Castro Vega, Francisco Javier, De los Santos Gil, Ignacio, García-Fraile, Lucio, Sampedro Núñez, Miguel, Barrios Blandino, Ana, Rodríguez Franco, Carlos, Useros Brañas, Daniel, Villa Martí, Almudena, Oliver Ortega, Javier, Costanza Espiño Álvarez, Alexia, Sanz Sanz, Jesús, Rexach Fumaña, María, Policarpo Torres, Guillem, Ortega Montoliu, Meritxell, Sala Jofre, Clara, Casas Rodríguez, Susana, Tortajada Alamilla, Cecilia, Oltra, Carmina, Masiá Canuto, Mar, Gutiérrez Rodero, Félix, Oltra Sempere, María Rosa, Vela Berna, Sara, Pedromingo Kus, Miguel, Garcinuño, María Ángeles, De la Vega, Alexandra, Pérez Pinto, Sergio, Hernández Machín, Pilar, Alastrué Violeta, Alba, Fariñas Álvarez, María Carmen, González Rico, Claudia, Arnaiz de las Revillas, Francisco, Calvo, Jorge, Gozalo, Mónica, Mora Gómez, Francisco, Milagro Beamonte, Ana, Latorre-Millán, Miriam, Rezusta López, Antonio, Martínez Sapiña, Ana, Meije, Yolanda, Ribera Puig, Alba, Ortega Enciso, Lucía, Sanz Salvador, Xavier, Losa García, Juan Emilio, Velasco Arribas, María, Pérez-Rodríguez, M. Teresa, Pérez González, Alexandre, Belhassen-García, Moncef, Rodríguez-Alonso, Beatriz, López-Bernus, Amparo, Carbonell, Cristina, Torres Perea, Rafael, Cantón De Seoane, Juan, Alonso, Blanca, Kamal, Sara Lidia, Cajuela, Lucía, Roa, David, Cervero, Miguel, Oreja, Alberto, Avilés, Juan Pablo, Martín, Lidia, Pelegrín Senent, Iván, Rouco Esteves Marques, Rosana, Parra Ruiz, Jorge, Ramos Sesma, Violeta, Abadia Otero, Jésica, Salillas Hernando, Juan, Torres Sánchez del Arco, Robert, Torralba González de Suso, Miguel, Serrano Martínez, Alberto, Gilaberte Reyzábal, Sergio, Pacheco Martínez-Atienza, Marina, Liébana Gómez, Mónica, Fernández Rodríguez, Sara, Varela Plaza, Álvaro, Calvo Sánchez, Henar, Martínez Martín, Patricia, González- Ruano, Patricia, Malmierca Corral, Eduardo, Rábago Lorite, Isabel, Pérez-Monte Mínguez, Beatriz, García Flores, Ángeles, Comas Casanova, Pere, Sirisi, Merce, Rojas, Richard, Díaz de Tuesta del Arco, José Luis, Figueroa Cerón, Ruth, González Sarria, Ander, Alemán Valls, Remedios, Alonso Socas, María del Mar, Sanz Peláez, Oscar, Mohamed Ramírez, Karim, Riera Jaume, Melchor, Vilchez, Helem Haydee, Albertí, Francesc, Cañabate, Ana Isabel, Moreno Cuerda, Víctor J, Álvarez Kaelis, Silvia, Álvarez Zapatero, Beatriz, García García, Alejandro, Isaba Ares, Elena, Morcate Fernández, Covadonga, Pérez Rodríguez, Andrea, Ramos Merino, Lucía, Castelo Corral, Laura, Rodríguez Mahía, María, González Bardanca, Mónica, Sánchez Vidal, Efrén, Míguez Rey, Enrique, Correa Ruiz, Ana, García de Lomas Guerrero, José Mº, Daniel López, Daniel, Marinas, Rebeca, Morando, Marta, Gómez García, Lucía, Boix Palop, Lucia, Dietl Gómez-Luengo, Beatriz, Pedrola Gorrea, Iris, Blasco Claramunt, Amparo, López Mestanza, Cristina, Fraile Villarejo, Esther, Jaén Sánchez, Nieves, Orihuela Martín, Jorge, Algado Rabasa, José Tomas, Garijo Saiz, Ana María, Amador Prous, Concepción, Salavert Lletí, Miguel, Hernández Belmonte, Adriana, Martínez Goñi, Raquel, Navarro Vilasaró, Marta, Calzado Isbert, Sonia, Cervantes García, Manuel, Gomila Grange, Aina, Gasch Blasi, Oriol, Machado Sicilia, María Luisa, Van den Eynde Otero, Eva, Falgueras López, Luis, Navarro Sáez, María del Carmen, Martínez, Esteban, Marcos, Mº Ángeles, Mosquera, Mar, Blanco, José Luis, Laguno, Montserrat, Rojas, Jhon, González-Cordón, Ana, Inciarte, Alexy, Torres, Berta, De la Mora, Lorena, Soriano, Alex, Martínez Macia, Olalla, Pérez Doñate, Virginia, Cabello Úbeda, Alfonso, Carrasco Antón, Nerea, Álvarez Álvarez, Beatriz, Petkova Saiz, Elizabet, Górgolas Hernández-Mora, Miguel, Prieto Pérez, Laura, Carrillo Acosta, Irene, Heili Frades, Sara, Villar Álvarez, Felipe, Fernández Roblas, Ricardo, Sánchez Pernaute, Olga, Fernández Espinilla, Virginia, Castrodeza Sanz, José Javier, Dueñas Gutiérrez, Carlos Jesús, González-Romo, Fernando, Merino Amador, Paloma, Rueda López, Alba, Martínez Jordán, Jorge, Medrano Pardo, Sara, Díaz de la Torre, Irene, Posada Franco, Yolanda, Delgado-Iribarren, Alberto, López-Contreras González, Joaquín, Pascual Alonso, Pablo, Pomar Solchaga, Virginia, Rabella García, Nuria, Benito Hernández, Natividad, Domingo Pedrol, Pere, Bonfill Cosp, Xavier, Padrós Selma, Rafael, Puig Campmany, Mireia, Mancebo Cortés, Jordi, Gurguí Ferrer, Mercè, Íñigo Pestaña, Melania, Pérez García, Alejandra, Sorní Moreno, Patricia, Izko Gartzia, Nora, Membrillo de Novales, Francisco Javier, Simón Sacristán, María, Zamora Cintas, Maribel, Martínez Martínez, Yolanda, Estébanez Muñoz, Miriam, Ramírez-Olivencia, Germán, Herrero Mendoza, María Dolores, De Dios García, Begoña, Mata Forte, Tatiana, Rodríguez Fernández, José María, Sáez de Adana Arróniz, Ester, Portu Zapirain, Joseba, Gainzarain Arana, Juan Carlos, Ortiz de Zárate Ibarra, Zuriñe, Moran Rodríguez, Miguel Ángel, Canut Blasco, Andrés, Hernáez Crespo, Silvia, Sanjosé Muñiz, Irene, Molina Iturritza, Estíbaliz, Ganchegui Aguirre, Maite, Urrestarazu Larrañag, Miren, De la Higuera Arranz, Carmen, Álvarez Padín, Pilar, Iglesias Llorente, Laura, Román Bernal, Berta, Sánchez Montalvá, Adrián, Espinosa Pereiro, Juan, Almirante, Benito, Miarons, Marta, Sellarés, Júlia, Larrosa, María, Villamarín, Miguel, Fernández, Nuria, Salvador, Fernando, Bosch-Nicolau, Pau, Pérez-Jorge Peremarch, Conchita, Resino Foz, Elena, Espigares Correa, Andrea, Álvarez de Espejo Montiel, Teresa, Navas Clemente, Iván, Quijano Contreras, María Isabel, Nieto Fernández del Campo, Luis Alberto, Jiménez Álvarez, Guillermo, Guillamón Sánchez, Mercedes, García García, Josefina, Muñoz Hornero, Constanza, Cosmen Sánchez, Ana, Mariño Callejo, Ana, Valcarce Pardeiro, Nieves, Smithson Amat, Alex, Chico Chumillas, Cristina, Sánchez Serrano, Adriana, Piñar Cabezos, Diana, Jiménez Martínez, Isabel, Estrada Fernández, Guillermo, Lorén Vargas, María, Parra Arribas, Nuria, Martínez Cilleros, Carmen, Villasante de la Puente, Aránzazu, García Delange, Teresa, Ruiz Rodríguez, María José, Robledo del Prado, Marta, Abad Almendro, Juan Carlos, Muñoz del Rey, José Román, Jiménez Álvaro, Montaña, Coy Coy, Javier, Poquet Catala, Inmaculada, Santos Peña, Marta, Mora Delgado, Juan, Manso Gómez, Tamara, Rubio Obanos, Teresa, Barbeito Castiñeiras, Gema, Domínguez Santalla, María Jesús, Mao Martín, Laura, Adalid Moll, María, Díaz Luperena, Javier, Ruiz Grinspan, Martín Sebastián, Barrós González, Raquel, Herrera Pacheco, Lourdes, Martínez Avilés, Rocío, Rodrigo González, Sara, Rodríguez Leal, Cristóbal Manuel, Romay Lema, Eva María, Suárez Gil, Roi, Bustinduy Odriozola, Maria Jesús, Marimón Ortiz de Zárate, José María, Vidaur Tello, Loreto, Kortajarena Urkola, Xabier, Arriola Martínez, Paula, Lartategi Iraurgi, Alazne, Álvarez de Castro, Maria, Martínez Mateu, Cintia María, Rodríguez Gómez, Francisco, Asschert Agüero, Isabel, Chamarro Martí, Elena, Franch Llasat, Diego, Zakariya-Yousef Breval, Ismail, Rico Rodríguez, Marta, Martínez López, Belén, García-López, María, Fernández Cruz, Ana, Calderón Parra, Jorge, Ramos Martínez, Antonio, Múñez Rubio, Elena, Vázquez Comendador, José Manuel, Diego Yagüe, Itziar, Expósito Palomo, Esther, Díaz de Santiago, Alberto, De la Fuente Moral, Sara, Pintos Pascual, Ilduara, Álvarez Franco, Raquel, Fernández de Orueta, Lucía, Vates Gómez, Roberto, Cardona Arias, Andrés Felipe, Marguenda Contreras, Pablo, Gaspar Alonso-Vega, Gabriel, Aranda Rife, Elena María, Martínez Cifre, Blanca, Roger Zapata, Daniel, Martín Rubio, Irene, Barbosa Ventura, André, Piñero, Iván, Bahamonde Carrasco, Alberto, Martínez Vidal, Ana, Talavera García, Eva, Mendoza Roy, Paula, Urrutia Losada, Ainhoa, Arteche Eguizabal, Lorea, Delgado Sánchez, Elisabet, Bañón Escandell, Sara, Caro Bragado, Sarah, Domínguez de Pablos, Gema, Herrero Rodríguez, Carmen, Liébana Martos, Carmen, Force Sanmartín, Luis, Aranega, Raquel, Mera Fidalgo, Arantzazu, Hortos Alsina, Miquel, Merchante Gutiérrez, Nicolas, León Jiménez, Eva María, Del Pozo, José L, Serralta Buades, Josefa, Cabrera Tejada, Ginger Giorgiana, Fernández-Ruiz, Mario, Aguado, José María, Maestro de la Calle, Guillermo, Vizcarra, Pilar, Rodriguez Dominguez, Mario José, Gioia, Francesca, Del Campo, Santos, Cantón Moreno, Rafael, Martín Dávila, Pilar, Casado, José Luis, Oteo Revuelta, José Antonio, Santibáñez Sáenz, Paula, Cervera Acedo, Cristina, Ruiz Martínez, Carlos, Blanco Ramos, José Ramón, Azcona Gutiérrez, José M., García García, Concepción, Alba Fernández, Jorge, Ibarra Cucalón, Valvanera, San Franco, Mercedes, Metola Sacristán, Luis, Meijide Míguez, Héctor, Gredilla Zubiría, Íñigo, Menéndez, Justo, Villares Fernández, Paula, Montes Andújar, Lara, Navarro Batet, Álvaro, Ferrer Santolaria, Anna, Padilla Salazar, María de la Luz, Abella Vázquez, Lucy, Hayek Peraza, Marcelino, García Pardo, Antonio, Hernández Carballo, Carolina, Ruiz Fernández, Andrés Javier, Barrio López, Isabel, Martakoush, Alí, Rojas-Vieyra, Agustín, García Calvo, Sonia, Villarreal García-Lomas, Mercedes, Vizcaíno Callejón, Marta, García García, María Pilar, Lérida Urteaga, Ana, Carrasco Fons, Natalia, María Sanjuan, Beatriz, Martín González, Lydia, Sanz Zamudio, Camilo, Alejos, Belén, Moreno, Cristina, Rava, Marta, Iniesta, Carlos, Izquierdo, Rebeca, Suárez-García, Inés, Díaz, Asunción, Ruiz-Alguero, Marta, Hernando, Victoria, Frías, Jesús, Ramírez, Elena, Martín-Quirós, Alejandro, Quintana-Díaz, Manuel, Mingorance, Jesús, Arnalich, Francisco, Moreno, Francisco, Figueiras, Juan Carlos, García-Arenzana, Nicolás, Montero-Vega, María Dolores, Romero-Gómez, María Pilar, Toro-Rueda, Carlos, García-Bujalance, Silvia, Ruiz-Carrascosa, Guillermo, Cendejas-Bueno, Emilio, Falces-Romero, Iker, Lázaro-Perona, Fernando, Ruiz-Bastián, Mario, Gutiérrez-Arroyo, Almudena, Girón De Velasco-Sada, Patricia, Dahdouh, Elie, Gómez-Arroyo, Bartolomé, García-Sánchez, Consuelo, Guedez-López, Virginia, Bloise-Sánchez, Iván, Alguacil-Guillén, Marina, Liras-Hernández, Maria Gracia, Sánchez-Castellano, Miguel Angel, García-Clemente, Paloma, González-Donapetry, Patricia, San José-Villar, S, de Pablos-Gómez, Manuela, Gómez-Gil, Rosa, Corcuera-Pindado, Maria Teresa, Rico-Nieto, Alicia, Herrero, Alicia, Prieto-Arribas, Daniel, Oliver-Saez, Paloma, Mora-Corcovado, Roberto, Fernández-Calle, Pilar, Alcaide-Martín, María José, Díaz-Garzón, Jorge, Fernández-Puntero, Belén, Nuñez-Cabetas, Rocío, Crespo-Sánchez, Gema, Rodriguez-Fraga, Olaia, Mendez del Sol, Helena, Duque-Alcorta, Marta, Gomez-Rioja, Rubén, Sanz de Pedro, María, Pascual-García, Lydia, Segovia-Amaro, Marta, Iturzaeta-Sánchez, Jose Manuel, Rodriguez-Gutiérrez, Mercedes, Perez-Garcia Morillón, Amparo, Martinez Gallego, Miguel Angel, Fabre-Estremera, Blanca, Martinez-Chavez, Estefanía, Moreno-Parra, Isabel, Rodriguez-Roca, Neila, Ortiz-Sánchez, Daniel, Simon-Velasco, Manuela, Gabriela-Tomoiu, Ileana, Pizarro-Sanchez, Cristina, Montero-San Martín, Blanca, Qasem-Moreno, Ana Laila, Gómez-López, Marta, Casares Guerrero, Ismael, Buño-Soto, Antonio, Martí de Gracia, Milagros, Parra-Gordo, Luz, Diez-Tascón, Aurea, Ossaba-Vélez, Silvia, Pinilla, Inmaculada, Cuesta, Emilio, Fernández-Velilla, María, Torres, Maria Isabel, Garzón, Gonzalo, Pérez-Blanco, Verónica, Quintás-Viqueira, Almudena, San Juan, Isabel, Cantero-Escribano, José Miguel, Pérez-Romero, César, Castro-Martínez, Mercedes, Hernández-Rivas, Lucía, Pedraz, Teresa, Fernández-Bretón, Eva, García-Vaz, Claudia, Robustillo-Rodela, Ana, Torres Santos-Olmo, Rosario María, Rivera-Núñez, Angélica, Fernández-Fernández, Ignacio, Noguerol-Gutiérrez, Marina, Martínez-Virto, Ana María, González-Viñolis, Manuel, Cabrera-Gamero, Regina, Mayayo-Alvira, Rosa, Marín-Baselga, Raquel, Lo-Iacono García, Victoria, Lerín-Baratas, Macarena, Romero Gallego-Acho, Paloma, Reche-Martínez, Begoña, Tejada-Sorados, Renzo, Rico-Briñas, Mikel, Deza-Palacios, Ricardo, Fabra-Cadenas, Sara, Arroyo-Rico, Isabel, Ben-Abdellah, Lubna Dani, Labajo-Montero, Laura, Soriano-Arroyo, Rubén, López-Corcuer, Lorena, Calvin-García, Elena, Martínez-Álvarez, Susana, López-Tappero Irazábal, Laura, Pilares-Barco, Martín, González-Peña, Olga, Bejarano-Redondo, Guillermina, Iglesias-Sigüenza, Alberto, Tung-Chen, Yale, Maroun Eid, Charbel, Bravo-Lizcano, Ruth, Silvestre-Niño, Miguel, Perdomo-García, Frank, Alonso-González, Berta, Antón-Huguet, Berta, Arenas-Berenguer, Isabel, Cabré-Verdiell Surribas, Clara, Marqués-González, Francisco, Muñoz del Val, Elena, Ángeles Molina, María, Cancelliere-Fernández, Nataly, Pastor-Yvorra, Sivia, Frade-Pardo, Laura, López-Arévalo, Paloma, García, Isabel, Fernández-Capitán, Carmen, González-Garcia, Juan José, Herrero, Juan, Quesada Simón, María Angustias, Robles Marhuenda, Angel, Soto Abanedes, Clara, Noblejas Mozo, Ana María, Ramos, Juan Carlos, Jaras Hernandez, María Jesús, Martinez Robles, Elena, Moreno Fernandez, Alberto, Sanchez Purificación, Aquilino, Martin Gutiérrez, Juan Carlos, Martinez Hernández, Pedro Luis, Sancho Bueso, Teresa, Lorenzo Hernández, Alicia, Gutierrez Sancerni, Belén, Salgueiro, Giorgina, Martin Carbonero, Luz, Mostaza, Jose María, Martinez-López, María Angeles, Hontañón, Victor, Menéndez, Araceli, Alvarez Troncoso, Jorge, Castellano, Arancha, Marcelo-Calvo, Cristina, Vives-Beltrán, Ivo, Ramos Ruperto, Luis, Daroca-Bengoa, Germán, Arcos Rueda, María, Vasquez-Manau, Julia, Fernández Cidón, Pelayo, Rosario Herrero Gil, Carmen, Palmier Peláez, Esmeralda, Untoria Tabares, Yeray, Lahoz, Carlos, Estirado, Eva, Hernández, Clara, Garcia-Iglesias, Francisca, Monteoliva, Enrique, Martínez, Mónica, Vara, Marta, González Alegre, Teresa, Valencia, Maria Eulalia, Moreno, Victoria, Montes, Maria Luisa, Alcolea-Batres, Sergio, Cabanillas-Martín, Juan José, Carpio-Segura, Carlos, Casitas-Mateo, Raquel, Fernández-Bujarrabal Villoslada, Jaime, Fernández-Navarro, Isabel, Fernández-Lahera, Juan, García-Quero, Cristina, Hidalgo-Sánchez, María, Galera-Martínez, Raúl, García-Río, Francisco, Gómez-Carrera, Luis, Gómez-Mendieta, María Antonia, Mangas-Moro, Alberto, Martínez-Cerón, Elisabet, Martínez-Redondo, María, Martínez-Abad, Yolanda, Martínez-Verdasco, Antonio, Plaza-Moreno, Cristina, Quirós-Fernández, Sarai, Romera-Cano, Delia, Romero-Ribate, David, Sánchez-Sánchez, Begoña, Santiago-Recuerda, Ana, Villasante, Carlos, Zamarrón de Lucas, Ester, Arnalich-Montiel, Victoria, Mariscal-Aguilar, Pablo, Falcone, Adalgisa, Laorden-Escudero, Daniel, Prados Sánchez, María Concepción, Álvarez-Sala Walther, Rodolfo, García, Andony, Arévalo, Cristina, Gutiérrez, Carola, Yus, Santiago, Asensio, Maria José, Sánchez, Manolo, Añón, Jose Manuel, Manzanares, Jesús, García de Lorenzo, Abelardo, Perales, Eva, Civantos, Belén, Cachafeiro, Lucía, Agrifoglio, Alexander, Estébanez, Belén, Flores, Eva, Hernández, Mónica, Millán, Pablo, Rodríguez, Montserrat, Nanwani, Kapil, Arizcun, Beatriz, Pérez-Costa, Elena, Rodríguez-Álvarez, Diego, Sánchez-Martín, María, Quesada, Úrsula, Román-Hernández, Carmen, Dorao, Paloma, Álvarez-Rojas, Elena, Menéndez, Juan José, Verdú, Cristina, Gómez-Zamora, Ana, Schüffelmann, Cristina, Calderón-Llopis, Belén, Laplaza-González, María, Río-García, Miguel, Amores-Hernández, Irene, Rodríguez-Rubio, Miguel, de la Oliva, Pedro, Ruiz, Jose, Rosillo, Sandra, González, Oscar, Iniesta, Angel, Ponz, Ines, Muñoz-Ramón, José María, Hernández-Gancedo, María, Uña Orejón, Carmen R., Sanabria-Carretero, Pascual, Moreno Gómez-Limón, Isidro, Seiz-Martinez, Alverio, Guasch-Arévalo, Emilia, Martín-Carrasco, Cristina, Alvar, Elena, Serrá, Lucía, Iannuccelli, Fabricio, Latorre, Julieta, Casares, Sandra, Valbuena, Isabel, Díaz Díez Picazo, Luis, Rodríguez Roca, Cristina, Cervera, Omar, García de las Heras, Esteban, Durán, Pilar, Castro, Carmen, Manrique de Lara, Carlos, Veganzones, Javier, López-Tofiño, Araceli, Fernandez-Cerezo, Estefanía, Zurita, Sergio, López-Martinez, Mercedes, Prim, Teresa, Alvárez del Vayo, Julía, Alcaraz, Gabriela, Castro, Luis, Yagüe, Julio, Díaz-Carrasco, Sofía, González-Pizarro, Patricio, Montero, Ana, Sagra, Francisco Javier, Suárez, Alejandro, Díez-Porres, Leyre, Varela-Cerdeira, María, Alonso-Babarro, Alberto, Abellán Martínez, Francisco, Alonso-Eiras, Jorge Ignacio, Álvarez Brandt, Alejandra, Archinà, Martina, Arribas-Terradillos, Silvia, Baselga-Puente, Trinidad, Barco Núñez, Pilar, Barrera-López, Natalia Guadalupe, Barrera-López, Lorena, Bartrina-Tarrio, Andres, Bassani, Gemma, Betancort de la Torre, Paula, Blanco-Bartolomé, Irene, Blasco-Andres, Celia, Brieba-Plata, Lucía, Cadenas-Gota, Fernando, Carrera-Vázquez, Paloma, Cascajares-Sanz, Carlota, Catino, Arianna, Cavallé-Pulla, Raquel, Ceniza-Pena, Daniel, Conde-Alonso, Ylenia María, Currás-Sánchez, Laura, Daltro-Lage, Marcelo, Esteban-Romero, Ana, Fernández Vidal, María Luisa, Ferrer Ortiz, Inés, de la Fuente Regaño, Lydia, Galindo-Ballesteros, Pablo, Garcia-Bellido Ruiz, Sara, García-Mochales Fortún, Carlos, Gómez-Ballesteros, Teresa, Gómez-Domínguez, Cecilia, González-Aguado, Nelsa, González-García, Sofía, Guisández Martín, Jorge, Hernández-Liebo, Paula Alejandra, Hernando Nieto, Raquel, Llorente-Cortijo, Irene María, Marín-García, Antonio, López-Pirez, Pilar, Mejuto-Illade, Lucía, Palma, Marco, Peña-Hidalgo, Adrian, Platero-Dueñas, Lucía, Pujol-Pocull, David, Ramírez-Verdyguer, Miguel, Redondo-Gutierrez, Marta, Reinoso-Lozano, Francisco, Rodríguez-Revillas, Ana, Rodríguez Saenz de Urturi, Alejandro, Romero-Imaz, Lucía, Sánchez-Rico, Susana, Sánchez-Santiuste, Mónica, Serrano de la Fuente, Patricia, Serrano-Martín, Henar, Silva-Freire, Thamires, Soria-Alcaide, Eva, Suárez-Plaza, Andrés Enrique, Tejero-Soriano, Beatriz, Torrecillas-Mainez, Andrea, Torres-Cortés, Javier, Valentín-Pastrana Aguilar, María de las Mercedes, Villanueva-Freije, Angélica, Virgós-Varela, Marta, Yagüe-Barrado, Marta, Yustas-Benitez, Natalia, Nuñez, María Concepción, Montserrat, Jaime, Queiruga, Javier, Rodriguez-Mariblanca, Amelia, Martínez de Soto, Lucía, Urroz, Mikel, Seco, Enrique, Zubimendi, Mónica, Stuart, Stephan, Díaz, Lucía, García, Irene, García Morales, María Teresa, Martín-Vega, Alberto, Caro, Abel, Martínez-Alés, Gonzalo, Gutiérrez-Gutiérrez, Belén, del Toro, María Dolores, Borobia, Alberto M, Carcas, Antonio, Jarrín, Inmaculada, Yllescas, María, Ryan, Pablo, Pachón, Jerónimo, Carratalà, Jordi, Berenguer, Juan, Arribas, Jose Ramón, and Rodríguez-Baño, Jesús

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2021
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