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4. An exact analytical solution for generalized growth models driven by a Markovian dichotomic noise

Author

Aquino, G., Bologna, M., and Calisto, H.

Subjects
Condensed Matter - Statistical Mechanics
Abstract

Logistic growth models are recurrent in biology, epidemiology, market models, and neural and social networks. They find important applications in many other fields including laser modelling. In numerous realistic cases the growth rate undergoes stochastic fluctuations and we consider a growth model with a stochastic growth rate modelled via an asymmetric Markovian dichotomic noise. We find an exact analytical solution for the probability distribution providing a powerful tool with applications ranging from biology to astrophysics and laser physics.

Published
2010
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5. Simultaneous Measurement of Non-Commuting Observables

Author

Aquino, G. and Mehmani, B.

Subjects
Quantum Physics
Abstract

It is shown that the full unknown state of a spin-1/2 system, S, which, within Born's statistical interpretation, is meant as the state of an ensamble of identically prepared systems, can be determined with a simultaneous measurement with the help of an "assistant" system A whose initial state is known. The idea is to let S and A interact with each other in a known way during a proper interaction time, to measure simultaneously two observables, one of S and one of A and their correlation. One thus determines the three unknown components of the polarization vector of S by means of repeated experiments using a unique setting. In this way one can measure simultaneously all the non-commutative observables of S, which might seem prohibited in quantum mechanics., Comment: 10 pages, 1 figure; Proceedings of the Workshop "Beyond the Quantum" World Scientific (2007)

Published
2007
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7. Different consecutive training protocols to design an intervention program for overweight youth: a controlled study

Author

Fiorilli G, Iuliano E, Aquino G, Campanella E, Tsopani D, Di Costanzo A, Calcagno G, and di Cagno A

Subjects
exercise, obesity, adolescents, adherence, resistance training, Specialties of internal medicine, RC581-951
Abstract

Giovanni Fiorilli,1 Enzo Iuliano,1 Giovanna Aquino,1 Emidio Campanella,1 Despina Tsopani,2 Alfonso Di Costanzo,1 Giuseppe Calcagno,1 Alessandra di Cagno3 1Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy; 2Department of Motor and Health Sciences, National Kapodistrian University of Athens, Athens, Greece; 3Department of Motor, Human and Health Sciences, University of Rome “Foro Italico”, Rome, Italy Objective: To find the optimal exercise program to be recommended in reducing adiposity and promoting long-term physical activity adherence in a sample of overweight adolescents.Methods: Forty-five overweight adolescents were randomly divided into three exercise groups, to perform two phases of physical activity as follows: in the first phase, the first group performed a 16-week moderate-intensity resistance training (RT), the second group performed a 16-week high-intensity RT, and the third group performed a 16-week aerobic training (AT); in the second phase, all groups performed a 6-week AT. Anthropometric body composition and fitness measures were considered as outcome measures.Results: After the second protocol, both RT groups showed a significant improvement in percentage of fat mass (F2,76 = 5.843; p = 0.004; η2 = 0.133) and free fat mass (F2,76 = 6.254; p = 0.003; η2 = 0.141), and in fitness tests (p < 0.01). The VO2max values of the RT groups were significantly higher than those of the AT group (F2,38 = 4.264; p = 0.021; η2 = 0.183). The rate of adherence to exercise was an average of 94% in both RT groups, whereas in the AT group, it was 83%. During the 12-week post-intervention follow-up, the number of participants who continued to perform physical activities was significantly higher in both the RT groups than in the AT group (p < 0.05).Conclusion: The present study provides preliminary evidence that moderate-to-intense RT, followed by AT, can be an effective treatment for overweight adolescents, and the positive effects are maintained even after 12 weeks of follow-up. Keywords: exercise, obesity, adolescents, adherence, resistance training

Published
2017

8. An Italian Multicenter Perspective Harmonization Trial for the Assessment of MET Exon 14 Skipping Mutations in Standard Reference Samples

Author

Bironzo, P, Pepe, F, Russo, G, Pisapia, P, Gragnano, G, Aquino, G, Bessi, S, Buglioni, S, Bartoccini, F, Ferrero, G, Bresciani, M, Francia di Celle, P, Sibona, F, Giusti, A, Movilia, A, Farioli, R, Santoro, A, Salemi, D, Scarpino, S, Galafate, D, Tommasi, S, Lacalamita, R, Seminati, D, Sajjadi, E, Novello, S, Pagni, F, Troncone, G, Malapelle, U, Bironzo, Paolo, Pepe, Francesco, Russo, Gianluca, Pisapia, Pasquale, Gragnano, Gianluca, Aquino, Gabriella, Bessi, Silvia, Buglioni, Simonetta, Bartoccini, Federico, Ferrero, Giuseppina, Bresciani, Michela Anna, Francia di Celle, Paola, Sibona, Francesca, Giusti, Andrea, Movilia, Alessandra, Farioli, Renata Mariella, Santoro, Alessandra, Salemi, Domenico, Scarpino, Stefania, Galafate, Dino, Tommasi, Stefania, Lacalamita, Rosanna, Seminati, Davide, Sajjadi, Elham, Novello, Silvia, Pagni, Fabio, Troncone, Giancarlo, Malapelle, Umberto, Bironzo, P, Pepe, F, Russo, G, Pisapia, P, Gragnano, G, Aquino, G, Bessi, S, Buglioni, S, Bartoccini, F, Ferrero, G, Bresciani, M, Francia di Celle, P, Sibona, F, Giusti, A, Movilia, A, Farioli, R, Santoro, A, Salemi, D, Scarpino, S, Galafate, D, Tommasi, S, Lacalamita, R, Seminati, D, Sajjadi, E, Novello, S, Pagni, F, Troncone, G, Malapelle, U, Bironzo, Paolo, Pepe, Francesco, Russo, Gianluca, Pisapia, Pasquale, Gragnano, Gianluca, Aquino, Gabriella, Bessi, Silvia, Buglioni, Simonetta, Bartoccini, Federico, Ferrero, Giuseppina, Bresciani, Michela Anna, Francia di Celle, Paola, Sibona, Francesca, Giusti, Andrea, Movilia, Alessandra, Farioli, Renata Mariella, Santoro, Alessandra, Salemi, Domenico, Scarpino, Stefania, Galafate, Dino, Tommasi, Stefania, Lacalamita, Rosanna, Seminati, Davide, Sajjadi, Elham, Novello, Silvia, Pagni, Fabio, Troncone, Giancarlo, and Malapelle, Umberto

Abstract

Lung cancer remains the leading cause of cancer deaths worldwide. International societies have promoted the molecular analysis of MET proto-oncogene, receptor tyrosine kinase (MET) exon 14 skipping for the clinical stratification of non-small cell lung cancer (NSCLC) patients. Different technical approaches are available to detect MET exon 14 skipping in routine practice. Here, the technical performance and reproducibility of testing strategies for MET exon 14 skipping carried out in various centers were evaluated. In this retrospective study, each institution received a set (n = 10) of a customized artificial formalin-fixed paraffin-embedded (FFPE) cell line (Custom METex14 skipping FFPE block) that harbored the MET exon 14 skipping mutation (Seracare Life Sciences, Milford, MA, USA), which was previously validated by the Predictive Molecular Pathology Laboratory at the University of Naples Federico II. Each participating institution managed the reference slides according to their internal routine workflow. MET exon 14 skipping was successfully detected by all participating institutions. Molecular analysis highlighted a median Cq cut off of 29.3 (ranging from 27.1 to 30.7) and 2514 (ranging from 160 to 7526) read counts for real-time polymerase chain reaction (RT-PCR) and NGS-based analyses, respectively. Artificial reference slides were a valid tool to harmonize technical workflows in the evaluation of MET exon 14 skipping molecular alterations in routine practice.

Published
2023

9. Effects of combined training vs aerobic training on cognitive functions in COPD: a randomized controlled trial

Author

Aquino G, Iuliano E, di Cagno A, Vardaro A, Fiorilli G, Moffa S, Di Costanzo A, De Simone G, and Calcagno G

Subjects
physical training, cognition, resistance training, rehabilitation, respiratory disease., Diseases of the respiratory system, RC705-779
Abstract

Giovanna Aquino,1 Enzo Iuliano,1 Alessandra di Cagno,2 Angela Vardaro,3 Giovanni Fiorilli,1 Stefano Moffa,1 Alfonso Di Costanzo,1 Giuseppe De Simone,3 Giuseppe Calcagno1 1Department of Medicine and Health Sciences “Vincenzo Tiberio”, University of Molise, Campobasso, 2Department of Health Science, University ForoItalico, Rome, 3“Villa Margherita”, Benevento, Italy Aim: The aim of this study was to investigate the effects of high-intensity aerobic training (AT) and high-intensity aerobic training combined with resistance training (ie, combined training [CT]) on cognitive function in patients with COPD. Methods: Twenty-eight Caucasian male patients (68.35±9.64 years; mean ± SD) with COPD were recruited and randomized into two groups, AT and CT. Both groups performed physical reconditioning for 4 weeks, with a frequency of five training sessions per week. The CT group completed two daily sessions of 30 minutes: one aerobic session and one strength session, respectively; The AT group performed two 30-minute aerobic endurance exercise sessions on treadmill. Physical and cognitive function tests were performed before and after the training intervention performances. Results: Exercise training improved the following cognitive functions: long-term memory, verbal fluency, attentional capacity, apraxia, and reasoning skills (P

Published
2016

11. Psychological Well-Being and Social Participation Assessment in Visually Impaired Subjects Playing Torball: A Controlled Study

Author

Di Cagno, A., Iuliano, E., and Aquino, G.

Abstract

The aim of this study was to evaluate the differences in psychological well-being, symptomatic psychological disorders and social participation, between blind Torball players and non-players. Thirty blind male participants were recruited, 17 Torball players (aged 36.27 plus or minus 3.46) and 13 non-players (aged 34.80 plus or minus 2.53), and evaluated for social participation level, psychological well-being and symptomatic psychological disorders, using three validated self-report questionnaires: Participation Scale (PS), Psychological Well-Being Scale (PWBS) and Symptom Checklist 90 R (SCL-90-R) respectively. ANOVA showed significant overall differences between the two groups. The social restriction score in the non-player group was significantly higher (p less than 0.01) than the player group. The Torball player group showed significant better scores than non-player group in 5 of the 6 dimensions of the PWB Scale (p less than 0.01) and in 8 of the 10 dimensions of the SCL-90-R (7 dimensions p less than 0.01; 1 dimension p less than 0.05) and in the three global scores of the SCL-90-R (p less than 0.01). The results of this study showed a relationship between psychological well-being and social skills of visually impaired people and their Torball practice. (Contains 3 tables.)

Published
2013
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14. Correction to: Discrepancy of p16 immunohistochemical expression and HPV RNA in penile cancer. A multiplex in situ hybridization/immunohistochemistry approach study (Infectious Agents and Cancer, (2021), 16, 1, (22), 10.1186/s13027-021-00361-8)

Author

Marino F. Z., Sabetta R., Pagliuca F., Brunelli M., Aquino G., Perdona S., Botti G., Facchini G., Fiorentino F., Di Lauro G., De Sio M., De Vita F., Toni G., Reis R. B. D., Neder L., Franco R., Marino, F. Z., Sabetta, R., Pagliuca, F., Brunelli, M., Aquino, G., Perdona, S., Botti, G., Facchini, G., Fiorentino, F., Di Lauro, G., De Sio, M., De Vita, F., Toni, G., Reis, R. B. D., Neder, L., and Franco, R.

Abstract

Following publication of the original article [1], the authors identified an error in the author name of Federica Zito Marino. ● The incorrect author name is: Federico Zito Marino ● The correct author name is: Federica Zito Marino The author group has been updated above and the original article [1] has been corrected.

Published
2021

16. Cytological diagnosis of Xp11 translocation renal cell carcinoma: An unusual suspect in bone metastases from unknown primary malignancies

Author

Montella M., Franco R., Aquino G., Ronchi A., Zito Marino F., Di Napoli M., Pignata S., Cozzolino I., ZITO MARINO, Federica, Montella, M., Franco, R., Aquino, G., Ronchi, A., Zito Marino, F., Di Napoli, M., Pignata, S., Cozzolino, I., and ZITO MARINO, Federica

Subjects
FNAC, Male, Pathology, medicine.medical_specialty, renal cell carcinoma, Histology, Oncogene Proteins, Fusion, Biopsy, Fine-Needle, 030209 endocrinology & metabolism, Chromosomal translocation, TFE3, Bone Neoplasms, urologic and male genital diseases, Bone and Bones, Translocation, Genetic, Pathology and Forensic Medicine, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Renal cell carcinoma, Cytology, Medicine, Humans, bone metastasi, Neoplasm Metastasis, In Situ Hybridization, Fluorescence, Retrospective Studies, Chromosomes, Human, X, business.industry, Basic Helix-Loop-Helix Leucine Zipper Transcription Factors, Incidence (epidemiology), Bone metastasis, General Medicine, Xp11 translocation, Middle Aged, medicine.disease, female genital diseases and pregnancy complications, Kidney Neoplasms, Bloody, 030220 oncology & carcinogenesis, cytology, Neoplasms, Unknown Primary, Female, business
Abstract

Background: Renal cell carcinoma (RCC) constitutes 3% of all cancers, with a higher incidence in patients with age between 60 and 70 years. RCC frequently present as a metastatic tumor at diagnosis, and bones represent one of the most frequent sites. Many cases, mainly in young patients, includes the Xp11 translocation RCC. The cytological diagnosis of Xp11 translocation RCC in adult population it is rarely performed, likely for the morphological overlap with other adult renal cell carcinoma subtypes. Methods: We retrospectively analyze a series of 92 adult patients with metastatic bone tumors, diagnosed on fine-needle aspiration cytology (FNAC) samples, focusing mainly on the cytological, immunophenotypic and molecular features of Xp11 translocation RCC. Results: In our series 6 of 92 (6.5%) cases were metastatic RCC (mRCC), among them 2 cases were metastasis from Xp11translocation RCC. Those cases showed a bloody background, with several groups of atypical cells arranged in syncytial groups or in papillary groups composed by atypical cells with abundant cytoplasm, with scattered clear cells. TFE3 was positive on immunocytochemical analysis and specific translocation t(Xp11.23) was detected by FISH analysis. Conclusions: In adult patients with mRCC, it is necessary to consider also Xp11 translocation RCC among the diagnostic hypotheses. FNAC represents a valid tool to investigate bone lesions but cytological features of Xp11 translocation RCC are still poorly described and must necessarily be better defined.

Published
2020

20. Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis

Author

Palma, C., Rocca, C. La, Gigantino, V., Aquino, G., Piccaro, G., Silvestre, D. Di, Brambilla, F., Rossi, R., Bonacina, F., Lepore, M.T., Audano, M., Mitro, N., Botti, G., Bruzzaniti, S., Fusco, C., Procaccini, C., Rosa, V. De, Galgani, M., Alviggi, C., Puca, A., Grassi, F., Rezzonico-Jost, T., Norata, G.D., Mauri, P., Netea, M.G., Candia, P. de, Matarese, G., Palma, C., Rocca, C. La, Gigantino, V., Aquino, G., Piccaro, G., Silvestre, D. Di, Brambilla, F., Rossi, R., Bonacina, F., Lepore, M.T., Audano, M., Mitro, N., Botti, G., Bruzzaniti, S., Fusco, C., Procaccini, C., Rosa, V. De, Galgani, M., Alviggi, C., Puca, A., Grassi, F., Rezzonico-Jost, T., Norata, G.D., Mauri, P., Netea, M.G., Candia, P. de, and Matarese, G.

Abstract

Item does not contain fulltext, There is a strong relationship between metabolic state and susceptibility to Mycobacterium tuberculosis (MTB) infection, with energy metabolism setting the basis for an exaggerated immuno-inflammatory response, which concurs with MTB pathogenesis. Herein, we show that controlled caloric restriction (CR), not leading to malnutrition, protects susceptible DBA/2 mice against pulmonary MTB infection by reducing bacterial load, lung immunopathology, and generation of foam cells, an MTB reservoir in lung granulomas. Mechanistically, CR induced a metabolic shift toward glycolysis, and decreased both fatty acid oxidation and mTOR activity associated with induction of autophagy in immune cells. An integrated multi-omics approach revealed a specific CR-induced metabolomic, transcriptomic, and proteomic signature leading to reduced lung damage and protective remodeling of lung interstitial tightness able to limit MTB spreading. Our data propose CR as a feasible immunometabolic manipulation to control MTB infection, and this approach offers an unexpected strategy to boost immunity against MTB.

Published
2021

22. Physical exercise for prevention of dementia (EPD) study: background, design and methods

Author

Iuliano E., Di Cagno A., Cristofano A., Angiolillo A., D'Aversa R., Ciccotelli S., Corbi G., Fiorilli G., Calcagno G., Di Costanzo A., Aquino G., Arcari V., Buongusto L., Cavallo G., Faraone M., Ferrara N., Filangieri M., Fiscarelli M., Iavarone S., Iannetta F., Moffa S., Mignogna P., Oriani G., Palombo F., PANICHELLA, NAZARENO, Pedata S., Petti B., Spaziano M., Taglialatela M., Valente R., Iuliano, E., Di Cagno, A., Cristofano, A., Angiolillo, A., D'Aversa, R., Ciccotelli, S., Corbi, G., Fiorilli, G., Calcagno, G., Di Costanzo, A., Aquino, G., Arcari, V., Buongusto, L., Cavallo, G., Faraone, M., Ferrara, N., Filangieri, M., Fiscarelli, M., Iavarone, S., Iannetta, F., Moffa, S., Mignogna, P., Oriani, G., Palombo, F., Panichella, Nazareno, Pedata, S., Petti, B., Spaziano, M., Taglialatela, M., and Valente, R.

Subjects
Male, medicine.medical_specialty, Aging population, 030209 endocrinology & metabolism, Physical exercise, Prevention of dementia, Risk Assessment, law.invention, Study Protocol, 03 medical and health sciences, Cognition, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, Memory, law, Humans, Medicine, Dementia, Cognitive Dysfunction, 030212 general & internal medicine, Cognitive decline, Exercise, Aged, Mild cognitive impairment, Neuropsychological test, Physical activity, Subjective memory complaints, Subjective memory complaint, business.industry, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Middle Aged, medicine.disease, Cognitive test, Physical therapy, Female, Observational study, Independent Living, business, Program Evaluation
Abstract

Background Several observational studies have shown that exercise reduces the risk of cognitive decline; however, evidences from long-term, well-conducted, randomized controlled trials are scanty. The principal aim of this study is to verify whether a long-term program of multimodal supervised exercise improves the cognitive function and/or reduces the rate of cognitive decline in older adults at different degrees of risk for dementia. Methods/design EPD is a parallel group, double-blind, randomized controlled trial. Community-dwelling volunteers aged 50 years or more are being recruited from different community centers and screened for eligibility. Enrolled subjects are being divided in 3 groups: a) without subjective or objective cognitive impairment, b) with subjective memory complaints, and c) with mild cognitive impairments. Participants in each group (at least 180) are being randomly assigned (1:1) to an experimental group, performing a supervised training including aerobic and resistance exercises of moderate/high intensity, or to a control group. Primary outcome will be 48-months changes in Mini Mental State Examinations. Secondary outcomes will be changes in several cognitive tests including a composite cognitive score. Time points will be at baseline, and at 6, 12, 24, 36 and 48 months. Statistical analysis will be done as intention to treat, complete case and mixed model analysis. Discussion EPD is the first trial to examine the effects of a long exercise program (48 months) on cognitive performances. If successful, this trial may provide evidence for using long-term and multimodal exercise interventions for dementia prevention programs in the aging population. Trial registration The study is registered at ClinicalTrials.gov with the code NCT02236416.

Published
2019

27. Synthesis and structural studies on (E)-3-(2,6-difluorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one: a promising nonlinear optical material

Author

Borges, I. D., primary, Danielli, J. A. V., additional, Silva, V. E. G., additional, Sallum, L. O., additional, Queiroz, J. E., additional, Dias, L. D., additional, Iermak, I., additional, Aquino, G. L. B., additional, Camargo, A. J., additional, Valverde, C., additional, Osório, F. A. P., additional, Baseia, B., additional, and Napolitano, H. B., additional

Published
2020
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28. Does straw mulch partial-removal from soil interfere in yield and industrial quality sugarcane? a long term study

Author

AQUINO, G. S. de, MEDINA, C. de C., SHAHABA, M., SANTIAGO, A. D., CUNHA, A. C. B., KUSSABAA, D. A. O., CARVALHO, J. B., MOREIRA, A., GISELE SILVA DE AQUINO, CRISTIANE DE CONTI MEDINA, MUHAMMAD SHAHABA, ANTONIO DIAS SANTIAGO, CPATC, ANA CAROLINA BENITEZ CUNHA, DEISE AKEMI OMORI KUSSABAA, JESSICA BARBIERI CARVALHO, and ADONIS MOREIRA, CNPSO.

Subjects
Cana de Açúcar, Bioenergia, Bioenergy, Biomassa, Biomass, Indústria, Cane sugar
Abstract

Made available in DSpace on 2019-03-28T00:33:21Z (GMT). No. of bitstreams: 1 2018Doesstraw.pdf: 746785 bytes, checksum: c76af3c0c01886bdfc5d0bf662b585a3 (MD5) Previous issue date: 2018

Published
2018

30. MALT GASTRIC LYMPHOMA: AN UPDATE OF PATHOGENETIC FEATURES

Author

Ronchi, A, Montella, M, Panarese, I, Costanzo, RMA, Aquino, G, De Chiara, A, Franco, R, Zito Marino, F, Ronchi, A, Montella, M, Panarese, I, Costanzo, Rma, Aquino, G, De Chiara, A, Franco, R, and Zito Marino, F

Subjects
MALT, immune system diseases, Pathogenesi, hemic and lymphatic diseases, Gastric lymphoma, MALT lymphoma, H. pylori
Abstract

Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) is a low-grade lymphoma comprising 7-8% of all B-cell non-Hodgkin lymphomas. Common sites of involvement include lung, head and neck, ocular adnexa, skin, thyroid and breast, but the gastrointestinal tract is by far the most common site and the stomach is involved in almost two-thirds of all cases. Infection and autoimmune diseases are commonly considered as etiopathogenetic factors, being related to chronic stimulation of B-cell proliferation. The association between Helicobacter pylori infection and gastric MALT lymphoma provides the best evidence of an etiopathogenetic link between lymphoma and infection. Indeed, successful eradication of this microorganism can be followed by lymphoma regression in most cases. In recent years the role of other pathogenetic factors including genetic predisposition, somatic genetic mutations and chemokines activity, has become more evident. Particularly specific genetic abnormalities have been observed in MALT lymphomas, with different distribution accordingly to the site of development.This review, therefore, addresses the major findings obtained in the last few years about MALT lymphoma and summarizes recent advances in its molecular pathogenesis.

Published
2016

31. Different consecutive training protocols to design an intervention program for overweight youth: A controlled study

Author

Fiorilli, G. Iuliano, E. Aquino, G. Campanella, E. Tsopani, D. Di Costanzo, A. Calcagno, G. Di Cagno, A.

Abstract

Objective: To find the optimal exercise program to be recommended in reducing adiposity and promoting long-term physical activity adherence in a sample of overweight adolescents. Methods: Forty-five overweight adolescents were randomly divided into three exercise groups, to perform two phases of physical activity as follows: in the first phase, the first group performed a 16-week moderate-intensity resistance training (RT), the second group performed a 16-week high-intensity RT, and the third group performed a 16-week aerobic training (AT); in the second phase, all groups performed a 6-week AT. Anthropometric body composition and fitness measures were considered as outcome measures. Results: After the second protocol, both RT groups showed a significant improvement in percentage of fat mass (F2,76= 5.843; p = 0.004; η2= 0.133) and free fat mass (F2,76= 6.254; p = 0.003; η2= 0.141), and in fitness tests (p < 0.01). The VO2max values of the RT groups were significantly higher than those of the AT group (F2,38= 4.264; p = 0.021; η2= 0.183). The rate of adherence to exercise was an average of 94% in both RT groups, whereas in the AT group, it was 83%. During the 12-week post-intervention follow-up, the number of participants who continued to perform physical activities was significantly higher in both the RT groups than in the AT group (p < 0.05). Conclusion: The present study provides preliminary evidence that moderate-to-intense RT, followed by AT, can be an effective treatment for overweight adolescents, and the positive effects are maintained even after 12 weeks of follow-up. © 2017 Fiorilli et al.

Published
2017

32. Sugarcane straw management and its impact on production and development of ratoons

Author

AQUINO, G. S. de, MEDINA, C. de C., COSTA, D. C. da, SHAHAB, M., SANTIAGO, A. D., GISELE SILVA DE AQUINO, CRISTIANE DE CONTI MEDINA, DAIRI CORTEZ DA COSTA, MUHAMMAD SHAHAB, and ANTONIO DIAS SANTIAGO, CPATC.

Subjects
Cana de açúcar, Sugar cane
Abstract

Made available in DSpace on 2017-09-28T10:33:51Z (GMT). No. of bitstreams: 1 Sugarcane.pdf: 1216237 bytes, checksum: a5e57ed0e2c91050e1e4ea35ec51a9a4 (MD5) Previous issue date: 2017-09-27

Published
2017

33. Agility and change of direction in soccer: Differences according to the player ages

Author

Fiorilli, G. Mitrotasios, M. Iuliano, E. Pistone, E.M. Aquino, G. Calcagno, G. Di Cagno, A.

Abstract

BACKGROUND: The goal of this study was to compare the changes of direction speed (CODS) and reactive agility (RA) in soccer players of different ages, in order to optimize the best training of these skills. METHODS: One hundred eighty-seven players, divided into bi-annual age-groups, U12, U14, U16 and U18, performed two tests: Y-Agility Test, carried out in planned and reactive mode (Y-PLAN and Y-REAC) and Illinois for Change of Direction Test (ICODT). Difference between Y-REAC minus Y-PLAN represents the index of reactivity (REAC-INDEX). RESULTS: MANOVA showed significant differences among groups (F3, 182=14.591; P

Published
2017

37. Autophagy analysis in oral carcinogenesis

Author

de Lima, T.B., primary, Paz, A.H.R., additional, Rados, P.V., additional, Leonardi, R., additional, Bufo, P., additional, Pedicillo, M.C., additional, Santoro, A., additional, Cagiano, S., additional, Aquino, G., additional, Botti, G., additional, Pannone, G., additional, and Visioli, F., additional

Published
2017
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43. Vegetative Waste Management on Sugarcane Yield and Industrial Quality.

Author

Aquino, G. S., Medina, C. C., Cunha, A. C. B., Kussaba, D. A. O., and Moreira, A.

Subjects
*WASTE management, *SUGARCANE, *CROP yields, *BIOMASS energy, *CROP management
Abstract

Sugarcane (Saccharum officinarum L.) has economic importance in tropical and/or subtropical regions, because of the high sucrose content for cost-effective sugar and ethanol production. The aim of this study was to evaluate the impact of vegetative waste on crop yield and industrial quality of the sugarcane. The experiment was carried out in a Kaolinitic Typic Eutrorthox, loamy texture, using the following six treatments: no fire, but leaving 0, 5, 10, 15, and 20 Mg ha−1 of straw mulch without trash incorporation, and sugarcane with burning and manual cutting before the harvesting, with four replicates. We evaluated total stalk yield (TSY) and industrial quality based on the apparent sucrose contents in the stalks (Pol), fibers, apparent purity (AP), reducing sugar (RS), and total recoverable sugar (TRS). The TSY after harvest, industrial quality at 180 and 240 days after harvest (DAH) and at the pre-harvest (350 days DAH) were also evaluated. The vegetative wastes had no influence in industrial quality, but 10 and 15 Mg ha−1 provided TSY 32% higher than the burning and manual cutting and 0 and the 5 Mg ha−1 of straw mulch. The use of 50% of waste to produce energy in sugarcane industrial plant did not reduce crop yield or industrial quality. [ABSTRACT FROM AUTHOR]

Published
2019
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44. Planck pre-launch status: The Planck mission

Author

Tauber, J, Mandolesi, N, Puget, J, Banos, T, Bersanelli, M, Bouchet, F, Butler, R, Charra, J, Crone, G, Dodsworth, J, Efstathiou, G, Gispert, R, Guyot, G, Gregorio, A, Juillet, J, Lamarre, J, Laureijs, R, Lawrence, C, NØRGAARD NIELSEN, H, Passvogel, T, Reix, J, Texier, D, Vibert, L, Zacchei, A, Ade, P, Aghanim, N, Aja, B, Alippi, E, Aloy, L, Armand, P, Arnaud, M, Arondel, A, ARREOLA VILLANUEVA, A, Artal, E, Artina, E, Arts, A, Ashdown, M, Aumont, J, Azzaro, M, Bacchetta, A, Baccigalupi, C, Baker, M, Balasini, M, Balbi, A, Banday, A, Barbier, G, Barreiro, R, Bartelmann, M, Battaglia, P, Battaner, E, Benabed, K, Beney, J, Beneyton, R, Bennett, K, Benoit, A, Bernard, J, Bhandari, P, Bhatia, R, Biggi, M, Biggins, R, Billig, G, Blanc, Y, Blavot, H, Bock, J, Bonaldi, A, Bond, R, Bonis, J, Borders, J, Borrill, J, Boschini, L, Boulanger, F, Bouvier, J, Bouzit, M, Bowman, R, Bréelle, E, Bradshaw, T, Braghin, M, Bremer, M, Brienza, D, Broszkiewicz, D, Burigana, C, Burkhalter, M, Cabella, P, Cafferty, T, Cairola, M, Caminade, S, Camus, P, Cantalupo, C, Cappellini, B, Cardoso, J, Carr, R, Catalano, A, Cayón, L, Cesa, M, Chaigneau, M, Challinor, A, Chamballu, A, Chambelland, J, Charra, M, Chiang, L, Chlewicki, G, Christensen, P, Church, S, Ciancietta, E, Cibrario, M, Cizeron, R, Clements, D, Collaudin, B, Colley, J, Colombi, S, Colombo, A, Colombo, F, Corre, O, Couchot, F, Cougrand, B, Coulais, A, Couzin, P, Crane, B, Crill, B, Crook, M, Crumb, D, Cuttaia, F, Dörl, U, DA SILVA, P, Daddato, R, Damasio, C, Danese, L, D'Aquino, G, D'Arcangelo, O, Dassas, K, Davies, R, Davies, W, Davis, R, DE BERNARDIS, P, DE CHAMBURE, D, DE GASPERIS, G, DE LA FUENTE, M, DE PACO, P, DE ROSA, A, DE TROIA, G, DE ZOTTI, G, Dehamme, M, Delabrouille, J, Delouis, J, Désert, F, DI GIROLAMO, G, Dickinson, C, Doelling, E, Dolag, K, Domken, I, Douspis, M, Doyle, D, Du, S, Dubruel, D, Dufour, C, Dumesnil, C, Dupac, X, Duret, P, Eder, C, Elfving, A, Enlin, T, Eng, P, English, K, Eriksen, H, Estaria, P, Falvella, M, Ferrari, F, Finelli, F, Fishman, A, Fogliani, S, Foley, S, Fonseca, A, Forma, G, Forni, O, Fosalba, P, Fourmond, J, Frailis, M, Franceschet, C, Franceschi, E, François, S, Frerking, M, GÓMEZ REÑASCO, M, Górski, K, Gaier, T, Galeotta, S, Ganga, K, GARCÍA LÁZARO, J, Garnica, A, Gaspard, M, Gavila, E, Giard, M, Giardino, G, Gienger, G, GIRAUD HERAUD, Y, Glorian, J, Griffin, M, Gruppuso, A, Guglielmi, L, Guichon, D, Guillaume, B, Guillouet, P, Haissinski, J, Hansen, F, Hardy, J, Harrison, D, Hazell, A, Hechler, M, Heckenauer, V, Heinzer, D, Hell, R, HENROT VERSILLÉ, S, HERNÁNDEZ MONTEAGUDO, C, Herranz, D, Herreros, J, Hervier, V, Heske, A, Heurtel, A, Hildebrandt, S, Hills, R, Hivon, E, Hobson, M, Hollert, D, Holmes, W, Hornstrup, A, Hovest, W, Hoyland, R, Huey, G, Huffenberger, K, Hughes, N, Israelsson, U, Jackson, B, Jaffe, A, Jaffe, T, Jagemann, T, Jessen, N, Jewell, J, Jones, W, Juvela, M, Kaplan, J, Karlman, P, Keck, F, Keihänen, E, King, M, Kisner, T, Kletzkine, P, Kneissl, R, Knoche, J, Knox, L, Koch, T, Krassenburg, M, KURKI SUONIO, H, Lähteenmäki, A, Lagache, G, Lagorio, E, Lami, P, Lande, J, Lange, A, Langlet, F, Lapini, R, Lapolla, M, Lasenby, A, LE JEUNE, M, Leahy, J, Lefebvre, M, Legrand, F, LE MEUR, G, Leonardi, R, Leriche, B, Leroy, C, Leutenegger, P, Levin, S, Lilje, P, Lindensmith, C, LINDEN VØRNLE, M, Loc, A, Longval, Y, Lubin, P, Luchik, T, Luthold, I, MACIAS PEREZ, J, Maciaszek, T, Mactavish, C, Madden, S, Maffei, B, Magneville, C, Maino, D, Mambretti, A, Mansoux, B, Marchioro, D, Maris, M, Marliani, F, Marrucho, J, MARTÍ CANALES, J, MARTÍNEZ GONZÁLEZ, E, MARTÍN POLEGRE, A, Martin, P, Marty, C, Marty, W, Masi, S, Massardi, M, Matarrese, S, Matthai, F, Mazzotta, P, Mcdonald, A, Mcgrath, P, Mediavilla, A, Meinhold, P, Mélin, J, Melot, F, Mendes, L, Mennella, A, Mervier, C, Meslier, L, Miccolis, M, MIVILLE DESCHENES, M, Moneti, A, Montet, D, Montier, L, Mora, J, Morgante, G, Morigi, G, Morinaud, G, Morisset, N, Mortlock, D, Mottet, S, Mulder, J, Munshi, D, Murphy, A, Murphy, P, Musi, P, Narbonne, J, Naselsky, P, Nash, A, Nati, F, Natoli, P, Netterfield, B, Newell, J, Nexon, M, Nicolas, C, Nielsen, P, Ninane, N, Noviello, F, Novikov, D, Novikov, I, O'Dwyer, I, Oldeman, P, Olivier, P, Ouchet, L, Oxborrow, C, PÉREZ CUEVAS, L, Pagan, L, Paine, C, Pajot, F, Paladini, R, Pancher, F, Panh, J, Parks, G, Parnaudeau, P, Partridge, B, Parvin, B, Pascual, J, Pasian, F, Pearson, D, Pearson, T, Pecora, M, Perdereau, O, Perotto, L, Perrotta, F, Piacentini, F, Piat, M, Pierpaoli, E, Piersanti, O, Plaige, E, Plaszczynski, S, Platania, P, Pointecouteau, E, Polenta, G, Ponthieu, N, Popa, L, Poulleau, G, Poutanen, T, Prézeau, G, Pradell, L, Prina, M, Prunet, S, Rachen, J, Rambaud, D, Rame, F, Rasmussen, I, Rautakoski, J, Reach, W, Rebolo, R, Reinecke, M, Reiter, J, Renault, C, Ricciardi, S, Rideau, P, Riller, T, Ristorcelli, I, Riti, J, Rocha, G, Roche, Y, Pons, R, Rohlfs, R, Romero, D, Roose, S, Rosset, C, Rouberol, S, ROWAN ROBINSON, M, RUBIÑO MARTÍN, J, Rusconi, P, Rusholme, B, Salama, M, Salerno, E, Sandri, M, Santos, D, Sanz, J, Sauter, L, Sauvage, F, Savini, G, Schmelzel, M, Schnorhk, A, Schwarz, W, Scott, D, Seiffert, M, Shellard, P, Shih, C, Sias, M, Silk, J, Silvestri, R, Sippel, R, Smoot, G, Starck, J, Stassi, P, Sternberg, J, Stivoli, F, Stolyarov, V, Stompor, R, Stringhetti, L, Strommen, D, Stute, T, Sudiwala, R, Sugimura, R, Sunyaev, R, Sygnet, J, Türler, M, Taddei, E, Tallon, J, Tamiatto, C, Taurigna, M, Taylor, D, Terenzi, L, Thuerey, S, Tillis, J, Tofani, G, Toffolatti, L, Tommasi, E, Tomasi, M, Tonazzini, E, Torre, J, Tosti, S, Touze, F, Tristram, M, Tuovinen, J, Tuttlebee, M, Umana, G, Valenziano, L, Vallée, D, VAN DER VLIS, M, VAN LEEUWEN, F, Vanel, J, VAN TENT, B, Varis, J, Vassallo, E, Vescovi, C, Vezzu, F, Vibert, D, Vielva, P, Vierra, J, Villa, F, Vittorio, N, Vuerli, C, Wade, L, Walker, A, Wandelt, B, Watson, C, Werner, D, White, M, White, S, Wilkinson, A, Wilson, P, Woodcraft, A, Yoffo, B, Yun, M, Yurchenko, V, Yvon, D, Zhang, B, Zimmermann, O, Zonca, A, Zorita, D, TAUBER J. A, MANDOLESI N, PUGET J. L, BANOS T, BERSANELLI M, BOUCHET F. R, BUTLER R. C, CHARRA J, CRONE G, DODSWORTH J, EFSTATHIOU G, GISPERT R, GUYOT G, GREGORIO A, JUILLET J. J, LAMARRE J. M, LAUREIJS R. J, LAWRENCE C. R, NØRGAARD NIELSEN H. U, PASSVOGEL T, REIX J. M, TEXIER D, VIBERT L, ZACCHEI A, ADE P. A. R, AGHANIM N, AJA B, ALIPPI E, ALOY L, ARMAND P, ARNAUD M, ARONDEL A, ARREOLA VILLANUEVA A, ARTAL E, ARTINA E, ARTS A, ASHDOWN M, AUMONT J, AZZARO M, BACCHETTA A, BACCIGALUPI C, BAKER M, BALASINI M, BALBI A, BANDAY A. J, BARBIER G, BARREIRO R. B, BARTELMANN M, BATTAGLIA P, BATTANER E, BENABED K, BENEY J. L, BENEYTON R, BENNETT K, BENOIT A, BERNARD J. P, BHANDARI P, BHATIA R, BIGGI M, BIGGINS R, BILLIG G, BLANC Y, BLAVOT H, BOCK J. J, BONALDI A, BOND R, BONIS J, BORDERS J, BORRILL J, BOSCHINI L, BOULANGER F, BOUVIER J, BOUZIT M, BOWMAN R, BRÉELLE E, BRADSHAW T, BRAGHIN M, BREMER M, BRIENZA, DANIELE, BROSZKIEWICZ D, BURIGANA C, BURKHALTER M, CABELLA, PAOLO, CAFFERTY T, CAIROLA M, CAMINADE S, CAMUS P, CANTALUPO C. M, CAPPELLINI B, CARDOSO J. F, CARR R, CATALANO, Andrea, CAYÓN L, CESA M, CHAIGNEAU M, CHALLINOR A, CHAMBALLU A, CHAMBELLAND J. P, CHARRA M, CHIANG L. Y, CHLEWICKI G, CHRISTENSEN P. R, CHURCH S, CIANCIETTA E, CIBRARIO M, CIZERON R, CLEMENTS D, COLLAUDIN B, COLLEY J. M, COLOMBI S, COLOMBO A, COLOMBO F, CORRE O, COUCHOT F, COUGRAND B, COULAIS A, COUZIN P, CRANE B, CRILL B, CROOK M, CRUMB D, CUTTAIA F, DÖRL U, DA SILVA P, DADDATO R, DAMASIO C, DANESE L, D'AQUINO G, D'ARCANGELO O, DASSAS K, DAVIES R. D, DAVIES W, DAVIS R. J, DE BERNARDIS, Paolo, DE CHAMBURE D, DE GASPERIS G, DE LA FUENTE M. L, DE PACO P, DE ROSA A, DE TROIA, Grazia, DE ZOTTI G, DEHAMME M, DELABROUILLE J, DELOUIS J. M, DÉSERT F. X, DI GIROLAMO G, DICKINSON C, DOELLING E, DOLAG K, DOMKEN I, DOUSPIS M, DOYLE D, DU S, DUBRUEL D, DUFOUR C, DUMESNIL C, DUPAC X, DURET P, EDER C, ELFVING A, ENLIN T. A, ENG P, ENGLISH K, ERIKSEN H. K, ESTARIA P, FALVELLA M. C, FERRARI F, FINELLI F, FISHMAN A, FOGLIANI S, FOLEY S, FONSECA A, FORMA G, FORNI O, FOSALBA P, FOURMOND J. J, FRAILIS M, FRANCESCHET C, FRANCESCHI E, FRANÇOIS S, FRERKING M, GÓMEZ REÑASCO M. F, GÓRSKI K. M, GAIER T. C, GALEOTTA S, GANGA K, GARCÍA LÁZARO J, GARNICA A, GASPARD M, GAVILA E, GIARD M, GIARDINO G, GIENGER G, GIRAUD HERAUD Y, GLORIAN J. M, GRIFFIN M, GRUPPUSO A, GUGLIELMI L, GUICHON D, GUILLAUME B, GUILLOUET P, HAISSINSKI J, HANSEN F. K, HARDY J, HARRISON D, HAZELL A, HECHLER M, HECKENAUER V, HEINZER D, HELL R, HENROT VERSILLÉ S, HERNÁNDEZ MONTEAGUDO C, HERRANZ D, HERREROS J. M, HERVIER V, HESKE A, HEURTEL A, HILDEBRANDT S. R, HILLS R, HIVON E, HOBSON M, HOLLERT D, HOLMES W, HORNSTRUP A, HOVEST W, HOYLAND R. J, HUEY G, HUFFENBERGER K. M, HUGHES N, ISRAELSSON U, JACKSON B, JAFFE A, JAFFE T. R, JAGEMANN T, JESSEN N. C, JEWELL J, JONES W, JUVELA M, KAPLAN J, KARLMAN P, KECK F, KEIHÄNEN E, KING M, KISNER T. S, KLETZKINE P, KNEISSL R, KNOCHE J, KNOX L, KOCH T, KRASSENBURG M, KURKI SUONIO H, LÄHTEENMÄKI A, LAGACHE G, LAGORIO E, LAMI P, LANDE J, LANGE A, LANGLET F, LAPINI R, LAPOLLA M, LASENBY A, LE JEUNE M, LEAHY J. P, LEFEBVRE M, LEGRAND F, LE MEUR G, LEONARDI R, LERICHE B, LEROY C, LEUTENEGGER P, LEVIN S. M, LILJE P. B, LINDENSMITH C, LINDEN VØRNLE M, LOC A, LONGVAL Y, LUBIN P. M, LUCHIK T, LUTHOLD I, MACIAS PEREZ J. F, MACIASZEK T, MACTAVISH C, MADDEN S, MAFFEI B, MAGNEVILLE C, MAINO D, MAMBRETTI A, MANSOUX B, MARCHIORO D, MARIS M, MARLIANI F, MARRUCHO J. C, MARTÍ CANALES J, MARTÍNEZ GONZÁLEZ E, MARTÍN POLEGRE A, MARTIN P, MARTY C, MARTY W, MASI, Silvia, MASSARDI M, MATARRESE S, MATTHAI F, MAZZOTTA P, MCDONALD A, MCGRATH P, MEDIAVILLA A, MEINHOLD P. R, MÉLIN J. B, MELOT F, MENDES L, MENNELLA A, MERVIER C, MESLIER L, MICCOLIS M, MIVILLE DESCHENES M. A, MONETI A, MONTET D, MONTIER L, MORA J, MORGANTE G, MORIGI G, MORINAUD G, MORISSET N, MORTLOCK D, MOTTET S, MULDER J, MUNSHI D, MURPHY A, MURPHY P, MUSI P, NARBONNE J, NASELSKY P, NASH A, NATI, FEDERICO, NATOLI P, NETTERFIELD B, NEWELL J, NEXON M, NICOLAS C, NIELSEN P. H, NINANE N, NOVIELLO F, NOVIKOV D, NOVIKOV I, O'DWYER I. J, OLDEMAN P, OLIVIER P, OUCHET L, OXBORROW C. A, PÉREZ CUEVAS L, PAGAN L, PAINE C, PAJOT F, PALADINI R, PANCHER F, PANH J, PARKS G, PARNAUDEAU P, PARTRIDGE B, PARVIN B, PASCUAL J. P, PASIAN F, PEARSON D. P, PEARSON T, PECORA M, PERDEREAU O, PEROTTO L, PERROTTA F, PIACENTINI, Francesco, PIAT M, PIERPAOLI E, PIERSANTI O, PLAIGE E, PLASZCZYNSKI S, PLATANIA P, POINTECOUTEAU E, POLENTA, GIANLUCA, PONTHIEU N, POPA L, POULLEAU G, POUTANEN T, PRÉZEAU G, PRADELL L, PRINA M, PRUNET S, RACHEN J. P, RAMBAUD D, RAME F, RASMUSSEN I, RAUTAKOSKI J, REACH W. T, REBOLO R, REINECKE M, REITER J, RENAULT C, RICCIARDI, Sara, RIDEAU P, RILLER T, RISTORCELLI I, RITI J. B, ROCHA G, ROCHE Y, PONS R, ROHLFS R, ROMERO D, ROOSE S, ROSSET C, ROUBEROL S, ROWAN ROBINSON M, RUBIÑO MARTÍN J. A, RUSCONI P, RUSHOLME B, SALAMA M, SALERNO E, SANDRI M, SANTOS D, SANZ J. L, SAUTER L, SAUVAGE F, SAVINI, Giorgio, SCHMELZEL M, SCHNORHK A, SCHWARZ W, SCOTT D, SEIFFERT M. D, SHELLARD P, SHIH C, SIAS M, SILK J. I, SILVESTRI R, SIPPEL R, SMOOT G. F, STARCK J. L, STASSI P, STERNBERG J, STIVOLI, federico, STOLYAROV V, STOMPOR R, STRINGHETTI L, STROMMEN D, STUTE T, SUDIWALA R, SUGIMURA R, SUNYAEV R, SYGNET J. F, TÜRLER M, TADDEI E, TALLON J, TAMIATTO C, TAURIGNA M, TAYLOR D, TERENZI L, THUEREY S, TILLIS J, TOFANI G, TOFFOLATTI L, TOMMASI E, TOMASI M, TONAZZINI E, TORRE J. P, TOSTI S, TOUZE F, TRISTRAM M, TUOVINEN J, TUTTLEBEE M, UMANA G, VALENZIANO L, VALLÉE D, VAN DER VLIS M, VAN LEEUWEN F, VANEL J. C, VAN TENT B, VARIS J, VASSALLO E, VESCOVI C, VEZZU F, VIBERT D, VIELVA P, VIERRA J, VILLA F, VITTORIO N, VUERLI C, WADE L. A, WALKER A. R, WANDELT B. D, WATSON C, WERNER D, WHITE M, WHITE S. D. M, WILKINSON A, WILSON P, WOODCRAFT A, YOFFO B, YUN M, YURCHENKO V, YVON D, ZHANG B, ZIMMERMANN O, ZONCA A, ZORITA D., Tauber, J, Mandolesi, N, Puget, J, Banos, T, Bersanelli, M, Bouchet, F, Butler, R, Charra, J, Crone, G, Dodsworth, J, Efstathiou, G, Gispert, R, Guyot, G, Gregorio, A, Juillet, J, Lamarre, J, Laureijs, R, Lawrence, C, NØRGAARD NIELSEN, H, Passvogel, T, Reix, J, Texier, D, Vibert, L, Zacchei, A, Ade, P, Aghanim, N, Aja, B, Alippi, E, Aloy, L, Armand, P, Arnaud, M, Arondel, A, ARREOLA VILLANUEVA, A, Artal, E, Artina, E, Arts, A, Ashdown, M, Aumont, J, Azzaro, M, Bacchetta, A, Baccigalupi, C, Baker, M, Balasini, M, Balbi, A, Banday, A, Barbier, G, Barreiro, R, Bartelmann, M, Battaglia, P, Battaner, E, Benabed, K, Beney, J, Beneyton, R, Bennett, K, Benoit, A, Bernard, J, Bhandari, P, Bhatia, R, Biggi, M, Biggins, R, Billig, G, Blanc, Y, Blavot, H, Bock, J, Bonaldi, A, Bond, R, Bonis, J, Borders, J, Borrill, J, Boschini, L, Boulanger, F, Bouvier, J, Bouzit, M, Bowman, R, Bréelle, E, Bradshaw, T, Braghin, M, Bremer, M, Brienza, D, Broszkiewicz, D, Burigana, C, Burkhalter, M, Cabella, P, Cafferty, T, Cairola, M, Caminade, S, Camus, P, Cantalupo, C, Cappellini, B, Cardoso, J, Carr, R, Catalano, A, Cayón, L, Cesa, M, Chaigneau, M, Challinor, A, Chamballu, A, Chambelland, J, Charra, M, Chiang, L, Chlewicki, G, Christensen, P, Church, S, Ciancietta, E, Cibrario, M, Cizeron, R, Clements, D, Collaudin, B, Colley, J, Colombi, S, Colombo, A, Colombo, F, Corre, O, Couchot, F, Cougrand, B, Coulais, A, Couzin, P, Crane, B, Crill, B, Crook, M, Crumb, D, Cuttaia, F, Dörl, U, DA SILVA, P, Daddato, R, Damasio, C, Danese, L, D'Aquino, G, D'Arcangelo, O, Dassas, K, Davies, R, Davies, W, Davis, R, DE BERNARDIS, P, DE CHAMBURE, D, DE GASPERIS, G, DE LA FUENTE, M, DE PACO, P, DE ROSA, A, DE TROIA, G, DE ZOTTI, G, Dehamme, M, Delabrouille, J, Delouis, J, Désert, F, DI GIROLAMO, G, Dickinson, C, Doelling, E, Dolag, K, Domken, I, Douspis, M, Doyle, D, Du, S, Dubruel, D, Dufour, C, Dumesnil, C, Dupac, X, Duret, P, Eder, C, Elfving, A, Enlin, T, Eng, P, English, K, Eriksen, H, Estaria, P, Falvella, M, Ferrari, F, Finelli, F, Fishman, A, Fogliani, S, Foley, S, Fonseca, A, Forma, G, Forni, O, Fosalba, P, Fourmond, J, Frailis, M, Franceschet, C, Franceschi, E, François, S, Frerking, M, GÓMEZ REÑASCO, M, Górski, K, Gaier, T, Galeotta, S, Ganga, K, GARCÍA LÁZARO, J, Garnica, A, Gaspard, M, Gavila, E, Giard, M, Giardino, G, Gienger, G, GIRAUD HERAUD, Y, Glorian, J, Griffin, M, Gruppuso, A, Guglielmi, L, Guichon, D, Guillaume, B, Guillouet, P, Haissinski, J, Hansen, F, Hardy, J, Harrison, D, Hazell, A, Hechler, M, Heckenauer, V, Heinzer, D, Hell, R, HENROT VERSILLÉ, S, HERNÁNDEZ MONTEAGUDO, C, Herranz, D, Herreros, J, Hervier, V, Heske, A, Heurtel, A, Hildebrandt, S, Hills, R, Hivon, E, Hobson, M, Hollert, D, Holmes, W, Hornstrup, A, Hovest, W, Hoyland, R, Huey, G, Huffenberger, K, Hughes, N, Israelsson, U, Jackson, B, Jaffe, A, Jaffe, T, Jagemann, T, Jessen, 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Abstract

The European Space Agency's Planck satellite, launched on 14 May 2009, is the third-generation space experiment in the field of cosmic microwave background (CMB) research. It will image the anisotropies of the CMB over the whole sky, with unprecedented sensitivity (${{\Delta T}\over T}$ ~ 2 × 10-6) and angular resolution (~5 arcmin). Planck will provide a major source of information relevant to many fundamental cosmological problems and will test current theories of the early evolution of the Universe and the origin of structure. It will also address a wide range of areas of astrophysical research related to the Milky Way as well as external galaxies and clusters of galaxies. The ability of Planck to measure polarization across a wide frequency range (30-350 GHz), with high precision and accuracy, and over the whole sky, will provide unique insight, not only into specific cosmological questions, but also into the properties of the interstellar medium. This paper is part of a series which describes the technical capabilities of the Planck scientific payload. It is based on the knowledge gathered during the on-ground calibration campaigns of the major subsystems, principally its telescope and its two scientific instruments, and of tests at fully integrated satellite level. It represents the best estimate before launch of the technical performance that the satellite and its payload will achieve in flight. In this paper, we summarise the main elements of the payload performance, which is described in detail in the accompanying papers. In addition, we describe the satellite performance elements which are most relevant for science, and provide an overview of the plans for scientific operations and data analysis.

Published
2010

45. Evaluation of a combined triple method to detect causative HPV in oral and oropharyngeal squamous cell carcinomas: p16 Immunohistochemistry, Consensus PCR HPV-DNA, and In Situ Hybridization.[Identificatico Scopus: 2-s2.0-84857478688]

Author

Pannone G, Rodolico V, Santoro A, Lo Muzio L, Franco R, Botti G, Aquino G, Pedicillo MC, Cagiano S, Campisi G, Rubini C, Papagerakis S, Tornesello ML, Buonaguro FM, Bufo P., DE ROSA, GAETANO, STAIBANO, STEFANIA, Pannone, G, Rodolico, V, Santoro, A, Lo Muzio, L, Franco, R, Botti, G, Aquino, G, Pedicillo, Mc, Cagiano, S, Campisi, G, Rubini, C, Papagerakis, S, DE ROSA, Gaetano, Tornesello, Ml, Buonaguro, Fm, Staibano, Stefania, and Bufo, P.

Subjects
HN-SCC, HPV, Human papillomaviru, Methylation-Specific PCR, OPSCC, DNA consensus PCR, Epigenetic, Head and neck squamous cell carcinoma, OSCC, p16-IHC, Immunohistochemistry, IHC
Abstract

Recent emerging evidences identify Human Papillomavirus (HPV) related Head and Neck squamous cell carcinomas (HN-SCCs) as a separate subgroup among Head and Neck Cancers with different epidemiology, histopathological characteristics, therapeutic response to chemo-radiation treatment and clinical outcome. However, there is not a worldwide consensus on the methods to be used in clinical practice. The endpoint of this study was to demonstrate the reliability of a triple method which combines evaluation of: 1. p16 protein expression by immunohistochemistry (p16-IHC); 2. HPV-DNA genotyping by consensus HPV-DNA PCR methods (Consensus PCR); and 3 viral integration into the host by in situ hybridization method (ISH). This triple method has been applied to HN-SCC originated from oral cavity (OSCC) and oropharynx (OPSCC), the two anatomical sites in which high risk (HR) HPVs have been clearly implicated as etiologic factors. Methylation-Specific PCR (MSP) was performed to study inactivation of p16-CDKN2a locus by epigenetic events. Reliability of multiple methods was measured by Kappa statistics.All the HN-SCCs confirmed HPV positive by PCR and/or ISH were also p16 positive by IHC, with the latter showing a very high level of sensitivity as single test (100\% in both OSCC and OPSCC) but lower specificity level (74\% in OSCC and 93\% in OPSCC).Concordance analysis between ISH and Consensus PCR showed a faint agreement in OPSCC (κ = 0.38) and a moderate agreement in OSCC (κ = 0.44). Furthermore, the addition of double positive score (ISHpositive and Consensus PCR positive) increased significantly the specificity of HR-HPV detection on formalin-fixed paraffin embedded (FFPE) samples (100\% in OSCC and 78.5\% in OPSCC), but reduced the sensitivity (33\% in OSCC and 60\% in OPSCC). The significant reduction of sensitivity by the double method was compensated by a very high sensitivity of p16-IHC detection in the triple approach.Although HR-HPVs detection is of utmost importance in clinical settings for the Head and Neck Cancer patients, there is no consensus on which to consider the 'golden standard' among the numerous detection methods available either as single test or combinations. Until recently, quantitative E6 RNA PCR has been considered the 'golden standard' since it was demonstrated to have very high accuracy level and very high statistical significance associated with prognostic parameters. In contrast, quantitative E6 DNA PCR has proven to have very high level of accuracy but lesser prognostic association with clinical outcome than the HPV E6 oncoprotein RNA PCR. However, although it is theoretically possible to perform quantitative PCR detection methods also on FFPE samples, they reach the maximum of accuracy on fresh frozen tissue. Furthermore, worldwide diagnostic laboratories have not all the same ability to analyze simultaneously both FFPE and fresh tissues with these quantitative molecular detection methods. Therefore, in the current clinical practice a p16-IHC test is considered as sufficient for HPV diagnostic in accordance with the recently published Head and Neck Cancer international guidelines. Although p16-IHC may serve as a good prognostic indicator, our study clearly demonstrated that it is not satisfactory when used exclusively as the only HPV detecting method. Adding ISH, although known as less sensitive than PCR-based detection methods, has the advantage to preserve the morphological context of HPV-DNA signals in FFPE samples and, thus increase the overall specificity of p16/Consensus PCR combination tests.

Published
2012

46. Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015.

Author

Nanda, VGY, Peng, W, Hwu, P, Davies, MA, Ciliberto, G, Fattore, L, Malpicci, D, Aurisicchio, L, Ascierto, PA, Croce, CM, Mancini, R, Spranger, S, Gajewski, TF, Wang, Y, Ferrone, S, Vanpouille-Box, C, Wennerberg, E, Pilones, KA, Formenti, SC, Demaria, S, Tang, H, Fu, Y-X, Dummer, R, Puzanov, I, Tarhini, A, Chauvin, J-M, Pagliano, O, Fourcade, J, Sun, Z, Wang, H, Sanders, C, Kirkwood, JM, Chen, T-HT, Maurer, M, Korman, AJ, Zarour, HM, Stroncek, DF, Huber, V, Rivoltini, L, Thurin, M, Rau, T, Lugli, A, Pagès, F, Camarero, J, Sancho, A, Jommi, C, de Coaña, YP, Wolodarski, M, Yoshimoto, Y, Gentilcore, G, Poschke, I, Masucci, GV, Hansson, J, Kiessling, R, Scognamiglio, G, Sabbatino, F, Marino, FZ, Anniciello, AM, Cantile, M, Cerrone, M, Scala, S, D’alterio, C, Ianaro, A, Cirin, G, Liguori, G, Bott, G, Chapman, PB, Robert, C, Larkin, J, Haanen, JB, Ribas, A, Hogg, D, Hamid, O, Testori, A, Lorigan, P, Sosman, JA, Flaherty, KT, Yue, H, Coleman, S, Caro, I, Hauschild, A, McArthur, GA, Sznol, M, Callahan, MK, Kluger, H, Postow, MA, Gordan, R, Segal, NH, Rizvi, NA, Lesokhin, A, Atkins, MB, Burke, MM, Ralabate, A, Rivera, A, Kronenberg, SA, Agunwamba, B, Ruisi, M, Horak, C, Jiang, J, Wolchok, J, Liszkay, G, Maio, M, Mandalà, M, Demidov, L, Stoyakovskiy, D, Thomas, L, de la Cruz-Merino, L, Atkinson, V, Dutriaux, C, Garbe, C, Wongchenko, M, Chang, I, Koralek, DO, Rooney, I, Yan, Y, Dréno, B, Sullivan, R, Patel, M, Hodi, S, Amaria, R, Boasberg, P, Wallin, J, He, X, Cha, E, Richie, N, Ballinger, M, Smith, DC, Bauer, TM, Wasser, JS, Luke, JJ, Balmanoukian, AS, Kaufman, DR, Zhao, Y, Maleski, J, Leopold, L, Gangadhar, TC, Long, GV, Michielin, O, VanderWalde, A, Andtbacka, RHI, Cebon, J, Fernandez, E, Malvehy, J, Olszanski, AJ, Gause, C, Chen, L, Chou, J, Stephen Hodi, F, Brady, B, Mortier, L, Hassel, JC, Rutkowski, P, McNeil, C, Kalinka-Warzocha, E, Lebbé, C, Ny, L, Chacon, M, Queirolo, P, Loquai, C, Cheema, P, Berrocal, A, Eizmendi, KM, Bar-Sela, G, Hardy, H, Weber, JS, Grob, J-J, Marquez-Rodas, I, Schmidt, H, Briscoe, K, Baurain, J-F, Wolchok, JD, Pinto, R, De Summa, S, Garrisi, VM, Strippoli, S, Azzariti, A, Guida, G, Guida, M, Tommasi, S, Jacquelot, N, Enot, D, Flament, C, Pitt, JM, Vimond, N, Blattner, C, Yamazaki, T, Roberti, M-P, Vetizou, M, Daillere, R, Poirier-Colame, V, la Semeraro, M, Caignard, A, Slingluff, CL, Sallusto, F, Rusakiewicz, S, Weide, B, Marabelle, A, Kohrt, H, Dalle, S, Cavalcanti, A, Kroemer, G, Di Giacomo, AM, Wong, P, Yuan, J, Umansky, V, Eggermont, A, Zitvogel, L, Anna, P, Marco, T, Stefania, S, Francesco, M, Mariaelena, C, Gabriele, M, Antonio, AP, Franco, S, Roberti, MP, Enot, DP, Semeraro, M, Jégou, S, Flores, C, Kwon, BS, Anderson, AC, Borg, C, Aubin, F, Ayyoub, M, De Presbiteris, AL, Cordaro, FG, Camerlingo, R, Fratangelo, F, Mozzillo, N, Pirozzi, G, Patriarca, EJ, Caputo, E, Motti, ML, Falcon, R, Miceli, R, Capone, M, Madonna, G, Mallardo, D, Carrier, MV, Panza, E, De Cicco, P, Armogida, C, Ercolano, G, Botti, G, Cirino, G, Sandru, A, Blank, M, Balatoni, T, Olasz, J, Farkas, E, Szollar, A, Savolt, A, Godeny, M, Csuka, O, Horvath, S, Eles, K, Shoenfeld, Y, Kasler, M, Costantini, S, Capone, F, Moradi, F, Berglund, P, Leandersson, K, Linnskog, R, Andersson, T, Prasad, CP, Nigro, CL, Lattanzio, L, Proby, C, Syed, N, Occelli, M, Cauchi, C, Merlano, M, Harwood, C, Thompson, A, Crook, T, Bifulco, K, Ingangi, V, Minopoli, M, Ragone, C, Pessi, A, Mannavola, F, D’Oronzo, S, Felici, C, Tucci, M, Doronzo, A, Silvestris, F, Ferretta, A, Guida, S, Maida, I, Cocco, T, Passarelli, A, Quaresmini, D, Franzese, O, Palermo, B, Di Donna, C, Sperduti, I, Foddai, M, Stabile, H, Gismondi, A, Santoni, A, Nisticò, P, Sponghini, AP, Platini, F, Marra, E, Rondonotti, D, Alabiso, O, Fierro, MT, Savoia, P, Stratica, F, Quaglino, P, Di Monta, G, Corrado, C, Di Marzo, M, Ugo, M, Di Cecilia, ML, Nicola, M, Fusciello, C, Marra, A, Guarrasi, R, Baldi, C, Russo, R, Di Giulio, G, Faiola, V, Zeppa, P, Pepe, S, Gambale, E, Carella, C, Di Paolo, A, De Tursi, M, Marra, L, De Murtas, F, Sorrentino, V, Voinea, S, Panaitescu, E, Bolovan, M, Stanciu, A, Cinca, S, Botti, C, Aquino, G, Anniciello, A, Fortes, C, Mastroeni, S, Caggiati, A, Passarelli, F, Zappalà, A, Capuano, M, Bono, R, Nudo, M, Marino, C, Michelozzi, P, De Biasio, V, Battarra, VC, Formenti, S, Ascierto, ML, McMiller, TL, Berger, AE, Danilova, L, Anders, RA, Netto, GJ, Xu, H, Pritchard, TS, Fan, J, Cheadle, C, Cope, L, Drake, CG, Pardoll, DM, Taube, JM, Topalian, SL, Gnjatic, S, Nataraj, S, Imai, N, Rahman, A, Jungbluth, AA, Pan, L, Venhaus, R, Park, A, Lehmann, FF, Lendvai, N, Cohen, AD, Cho, HJ, Daniel, S, Hirsh, V, Nanda, VGY, Peng, W, Hwu, P, Davies, MA, Ciliberto, G, Fattore, L, Malpicci, D, Aurisicchio, L, Ascierto, PA, Croce, CM, Mancini, R, Spranger, S, Gajewski, TF, Wang, Y, Ferrone, S, Vanpouille-Box, C, Wennerberg, E, Pilones, KA, Formenti, SC, Demaria, S, Tang, H, Fu, Y-X, Dummer, R, Puzanov, I, Tarhini, A, Chauvin, J-M, Pagliano, O, Fourcade, J, Sun, Z, Wang, H, Sanders, C, Kirkwood, JM, Chen, T-HT, Maurer, M, Korman, AJ, Zarour, HM, Stroncek, DF, Huber, V, Rivoltini, L, Thurin, M, Rau, T, Lugli, A, Pagès, F, Camarero, J, Sancho, A, Jommi, C, de Coaña, YP, Wolodarski, M, Yoshimoto, Y, Gentilcore, G, Poschke, I, Masucci, GV, Hansson, J, Kiessling, R, Scognamiglio, G, Sabbatino, F, Marino, FZ, Anniciello, AM, Cantile, M, Cerrone, M, Scala, S, D’alterio, C, Ianaro, A, Cirin, G, Liguori, G, Bott, G, Chapman, PB, Robert, C, Larkin, J, Haanen, JB, Ribas, A, Hogg, D, Hamid, O, Testori, A, Lorigan, P, Sosman, JA, Flaherty, KT, Yue, H, Coleman, S, Caro, I, Hauschild, A, McArthur, GA, Sznol, M, Callahan, MK, Kluger, H, Postow, MA, Gordan, R, Segal, NH, Rizvi, NA, Lesokhin, A, Atkins, MB, Burke, MM, Ralabate, A, Rivera, A, Kronenberg, SA, Agunwamba, B, Ruisi, M, Horak, C, Jiang, J, Wolchok, J, Liszkay, G, Maio, M, Mandalà, M, Demidov, L, Stoyakovskiy, D, Thomas, L, de la Cruz-Merino, L, Atkinson, V, Dutriaux, C, Garbe, C, Wongchenko, M, Chang, I, Koralek, DO, Rooney, I, Yan, Y, Dréno, B, Sullivan, R, Patel, M, Hodi, S, Amaria, R, Boasberg, P, Wallin, J, He, X, Cha, E, Richie, N, Ballinger, M, Smith, DC, Bauer, TM, Wasser, JS, Luke, JJ, Balmanoukian, AS, Kaufman, DR, Zhao, Y, Maleski, J, Leopold, L, Gangadhar, TC, Long, GV, Michielin, O, VanderWalde, A, Andtbacka, RHI, Cebon, J, Fernandez, E, Malvehy, J, Olszanski, AJ, Gause, C, Chen, L, Chou, J, Stephen Hodi, F, Brady, B, Mortier, L, Hassel, JC, Rutkowski, P, McNeil, C, Kalinka-Warzocha, E, Lebbé, C, Ny, L, Chacon, M, Queirolo, P, Loquai, C, Cheema, P, Berrocal, A, Eizmendi, KM, Bar-Sela, G, Hardy, H, Weber, JS, Grob, J-J, Marquez-Rodas, I, Schmidt, H, Briscoe, K, Baurain, J-F, Wolchok, JD, Pinto, R, De Summa, S, Garrisi, VM, Strippoli, S, Azzariti, A, Guida, G, Guida, M, Tommasi, S, Jacquelot, N, Enot, D, Flament, C, Pitt, JM, Vimond, N, Blattner, C, Yamazaki, T, Roberti, M-P, Vetizou, M, Daillere, R, Poirier-Colame, V, la Semeraro, M, Caignard, A, Slingluff, CL, Sallusto, F, Rusakiewicz, S, Weide, B, Marabelle, A, Kohrt, H, Dalle, S, Cavalcanti, A, Kroemer, G, Di Giacomo, AM, Wong, P, Yuan, J, Umansky, V, Eggermont, A, Zitvogel, L, Anna, P, Marco, T, Stefania, S, Francesco, M, Mariaelena, C, Gabriele, M, Antonio, AP, Franco, S, Roberti, MP, Enot, DP, Semeraro, M, Jégou, S, Flores, C, Kwon, BS, Anderson, AC, Borg, C, Aubin, F, Ayyoub, M, De Presbiteris, AL, Cordaro, FG, Camerlingo, R, Fratangelo, F, Mozzillo, N, Pirozzi, G, Patriarca, EJ, Caputo, E, Motti, ML, Falcon, R, Miceli, R, Capone, M, Madonna, G, Mallardo, D, Carrier, MV, Panza, E, De Cicco, P, Armogida, C, Ercolano, G, Botti, G, Cirino, G, Sandru, A, Blank, M, Balatoni, T, Olasz, J, Farkas, E, Szollar, A, Savolt, A, Godeny, M, Csuka, O, Horvath, S, Eles, K, Shoenfeld, Y, Kasler, M, Costantini, S, Capone, F, Moradi, F, Berglund, P, Leandersson, K, Linnskog, R, Andersson, T, Prasad, CP, Nigro, CL, Lattanzio, L, Proby, C, Syed, N, Occelli, M, Cauchi, C, Merlano, M, Harwood, C, Thompson, A, Crook, T, Bifulco, K, Ingangi, V, Minopoli, M, Ragone, C, Pessi, A, Mannavola, F, D’Oronzo, S, Felici, C, Tucci, M, Doronzo, A, Silvestris, F, Ferretta, A, Guida, S, Maida, I, Cocco, T, Passarelli, A, Quaresmini, D, Franzese, O, Palermo, B, Di Donna, C, Sperduti, I, Foddai, M, Stabile, H, Gismondi, A, Santoni, A, Nisticò, P, Sponghini, AP, Platini, F, Marra, E, Rondonotti, D, Alabiso, O, Fierro, MT, Savoia, P, Stratica, F, Quaglino, P, Di Monta, G, Corrado, C, Di Marzo, M, Ugo, M, Di Cecilia, ML, Nicola, M, Fusciello, C, Marra, A, Guarrasi, R, Baldi, C, Russo, R, Di Giulio, G, Faiola, V, Zeppa, P, Pepe, S, Gambale, E, Carella, C, Di Paolo, A, De Tursi, M, Marra, L, De Murtas, F, Sorrentino, V, Voinea, S, Panaitescu, E, Bolovan, M, Stanciu, A, Cinca, S, Botti, C, Aquino, G, Anniciello, A, Fortes, C, Mastroeni, S, Caggiati, A, Passarelli, F, Zappalà, A, Capuano, M, Bono, R, Nudo, M, Marino, C, Michelozzi, P, De Biasio, V, Battarra, VC, Formenti, S, Ascierto, ML, McMiller, TL, Berger, AE, Danilova, L, Anders, RA, Netto, GJ, Xu, H, Pritchard, TS, Fan, J, Cheadle, C, Cope, L, Drake, CG, Pardoll, DM, Taube, JM, Topalian, SL, Gnjatic, S, Nataraj, S, Imai, N, Rahman, A, Jungbluth, AA, Pan, L, Venhaus, R, Park, A, Lehmann, FF, Lendvai, N, Cohen, AD, Cho, HJ, Daniel, S, and Hirsh, V

Abstract

MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. Y. Nanda, Weiyi Peng, Patrick Hwu, Michael A. Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini K3 Tumor-intrinsic beta-catenin signaling mediates tumor-immune avoidance Stefani Spranger, Thomas F. Gajewski K4 Intracellular tumor antigens as a source of targets of antibody-based immunotherapy of melanoma Yangyang Wang, Soldano Ferrone Combination therapies K5 Harnessing radiotherapy to improve responses to immunotherapy in cancer Claire Vanpouille-Box, Erik Wennerberg, Karsten A. Pilones, Silvia C. Formenti, Sandra Demaria K6 Creating a T cell-inflamed tumor microenvironment overcomes resistance to checkpoint blockade Haidong Tang, Yang Wang, Yang-Xin Fu K7 Biomarkers for treatment decisions? Reinhard Dummer K8 Combining oncolytic therapies in the era of checkpoint inhibitors Igor Puzanov K9 Immune checkpoint blockade for melanoma: should we combine or sequence ipilimumab and PD-1 antibody therapy? Michael A. Postow News in immunotherapy K10 An update on adjuvant and neoadjuvant therapy for melanom Ahmad Tarhini K11 Targeting multiple inhibitory receptors in melanoma Joe-Marc Chauvin, Ornella Pagliano, Julien Fourcade, Zhaojun Sun, Hong Wang, Cindy Sanders, John M. Kirkwood, Tseng-hui Timothy Chen, Mark Maurer, Alan J. Korman, Hassane M. Zarour K12 Improving adoptive immune therapy using genetically engineered T cells David F. Stroncek Tumor microenvironment and biomarkers K13 Myeloid cells and tumor exosomes: a crosstalk for assessing immunosuppression? Veronica Huber, Licia Rivoltini K14 Update on the SITC biomarker taskforce: progress and challenges Magdalena Thurin World-wide immunosc

Published
2016

47. Teaching Technology with Technology: Computer Assisted Lessons in the Medical School - The First Italian Experience in Nephrology and Dialysis

Author

Garofletti Y, Luigi Biancone, D'Aquino G, Giorgio Soragna, Manuel Burdese, Martino B, Daniela Bergamo, Marco Quaglia, Alberto Jeantet, Elisabetta Mezza, Massimo Gai, Gino M, Piccoli Gb, and Segoloni Gp

Subjects
Adult, Male, Nephrology, medicine.medical_specialty, Teaching technology, Students, Medical, 030232 urology & nephrology, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, 050108 psychoanalysis, Biomaterials, 03 medical and health sciences, 0302 clinical medicine, Renal Dialysis, Surveys and Questionnaires, Internal medicine, medicine, Humans, 0501 psychology and cognitive sciences, Medical education, business.industry, 05 social sciences, Medical school, General Medicine, Scale (social sciences), Female, Dialysis (biochemistry), business, Computer-Assisted Instruction, Education, Medical, Undergraduate, Program Evaluation
Abstract

BackgroundDialysis is often neglected in academic teaching. At the University of Torino, Italy, teaching Nephrology (4thyear of Medical School) consists of 21 hours of formal lessons, 10 hours/student of interactive lessons (4/10 dedicated to dialysis) and 10 optional lessons (3 regarding dialysis). Interactive and optional lessons widely employ computer assisted teaching. Aim of the study was to evaluate student satisfaction on this approach.MethodsStudent satisfaction was assessed on 4 sample lessons (166 students), by two short dedicated questionnaires (0–10 scale, open questions).ResultsHigh scores were given to the dialysis lessons (median 8/10). Computer assisted interface (median 8/10, range 6–10) was of help in check of knowledge in real time (86%), enhancing participation (61%); 62% suggest extending this experience to selected courses, 38% to all.ConclusionsMedical students consider dialysis an important part of the academic teaching of Nephrology; new interfaces may help to enhance student satisfaction.

Published
2002

49. Improving neuromuscular performance in young basketball players: plyometric vs. technique training

Author

Attene G, Iuliano E, Di Cagno A, Giuseppe Calcagno, Moalla W, Aquino G, and Padulo J

Subjects
Adolescent, Humans, Female, Basketball, Plyometric Exercise, Athletic Performance, Exercise
Abstract

The aim of this study was to compare the effects of plyometric training versus basketball technique training on improving neuro-muscular performance.Thirty-six (age 14.9±0.9 years, body height 164.0±7.6 cm, body weight 54.0±8.7 kg, BMI 20.1±2.4 kg·m-2) basketball players girls were randomly allocated to 2 groups: Basketball Plyometric Training (BPT, N.=18) and Basketball Technique Training (BTT, N.=18). The players were tested by two specific tests: counter movement jump (CMJ) and squat jump (SJ) before and after 6 training weeks.The jump height, as dependent variable, showed a different trend as an effect of the different training protocols, in contrast with the current knowledge. Manova did not show significant interactions between the two groups for the height of jumps, while significant differences were found for interaction time × training (P0.05) and for main effect × time (P0.001). After training, the BPT group increased significantly CMJ performance by 11.3% (P0.05), whereas the BTT group increased by 4.6%. Likewise, the BPT group demonstrated a significant greater improvement of jump height than BTT group (an increase of 15.4% vs. 7.5%, P0.01; respectively).These results suggest that both training protocols proposed in this study improved vertical jump performance. However, a combination of the two protocols, plyometric training and sport-specific-exercises, could be useful to optimize performance by an easy transition from controlled a-specific to sport-specific performance requirements. In conclusion, BPT is a safe and effective method of achieving a favourable neuro-muscular performance than BTT in female basketball players.

Published
2014

50. Time-of-day effects on static and dynamic balance in elite junior athletes and untrained adolescents

Author

Di Cagno, A. Fiorilli, G. Iuliano, E. Aquino, G. Giombini, A. Battaglia, C. Piazza, M. Tsopani, D. Calcagno, G.

Abstract

The aim of the present study was to analyse the daily variation of balance in two groups of female adolescents: elite athletes (n=20, aged 13.2 ± 0.5 years) and untrained students (n=20, aged 12.9 ± 0.6 years). Participants underwent two testing sessions over two days at two different times each day. Morningness-Eveningness self-assessment questionnaire was administered to assess the chronotype of the participants and oral temperature was measured too. Significant group differences were found in the overall balance tests (p

Published
2014

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