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Your search keyword '"Aquadro, C."' showing total 199 results
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199 results on '"Aquadro, C."'

1. Rapid Mutations in Mice?

Author

Johnson, F. M., Aquadro, C. F., Skow, L. C., Langley, C. H., Lewis, S. E., Green, Margaret C., Bailey, Donald W., Green, Earl L., Roderick, Thomas H., Russell, Elizabeth S., Fitch, Walter M., and Atchley, William R.

Published
1985

9. Cornell University Life Sciences Core Laboratories Center

Author

VanEe, J., Schweitzer, P., Zhang, S., Williams, R., Pillardy, J., Sun, Q., Wang, W., Li, Y., Betel, D., Stelick, T., Spisak, J., Cote, L., Cameron, R., Wroblewski, H., Hover, B., Zhang, L., Mosher, J., Xin, Y., Westby, G., Busuttil, J., Monni, S., Sherwood, R., Ptak, A.C., Chen, W., McCardle, J., Bayles, C., Dela Cruz, J., Riccio, M., Bukowski, R., Ponnala, L., Myers, C., Singh, H., Howard, M., Flaherty, J., Manocchia, A., Dodge, E., Smith, K., Aquadro, C., Melnick, A., Brenna, T., Zipfel, W., Clark, A., Siepel, A., Carr, L., Rose, J.K.C., and Grills, G.

Subjects
Poster Session Abstracts
Abstract

The Cornell University Life Sciences Core Laboratories Center (CLC) provides an array of genomics, proteomics, imaging and informatics shared research resources and services to the university community and to outside investigators. The CLC includes fee-for-service research, technology testing and development, and educational components. The Center has seven core facilities, including genomics (DNA sequencing, genotyping, and microarrays), epigenomics, proteomics and mass spectrometry, microscopy and imaging, bioinformatics, bio-IT, and advanced technology assessment. The CLC is part of a New York State designated Center for Advanced Technology in Life Science Enterprise. The mission of the CLC is to promote research in the life sciences with advanced technologies in a shared resource environment. Use of the CLC resources and services is steadily increasing due to the growth in the number and types of cores in the center, to the expansion of existing services and the implementation of new core technologies, and to the coordinated integration and synergy of services between the CLC cores. Multidisciplinary support for multi-functional instrument platforms is implemented by integrated operations of the CLC core facilities. Investigators are offered coordinated project consultations with the directors and staff of all relevant cores during the design, data production and analysis phases of their projects. The CLC is involved in establishing and supporting multidisciplinary research projects that involve both intercampus initiatives and multi-institutional collaborations. With a concentration of advanced instrumentation and expertise in their applications, the CLC is a key resource for life sciences research.

Published
2011

11. Cornell University Life Sciences Core Laboratories Center

Author

VanEe, J., Schweitzer, P., Wang, W., Li, Y., Zhang, S., Williams, R., Deng, K.Y., Pillardy, J., Sun, Q., Stelick, T., Spisak, J., Paronett, E., Cote, L., Cameron, R., Zhao, J., Hover, B., Kresovich, J., Xin, Y., Figueroa, M., Shaknovich, R., Monni, S., Unnsteinsdottir, U., Sherwood, R., Ptak, C., Yan, H., Bayles, C., Xia, G., Doran, R., Bukowski, R., Myers, C., Ponnala, L., Stefanov, S., Howard, M., Flaherty, J., Manocchia, A., Dodge, E., Smith, K., Aquadro, C., Lin, D., Melnick, A., Zipfel, W., Soloway, P., Jin, M., Clark, A., Siepel, A., Rose, J.K.C., and Grills, G.S.

Subjects
Poster Session Abstracts
Abstract

CF-13

Published
2010

13. Incompatibilities involving yeast mismatch repair genes: A role for genetic modifiers and implications for disease penetrance and variation in genomic mutation rates

Author

Demogines, A. (Ann), Wong, A. (Alex), Aquadro, C. (Charles), Alani, E. (Eric), Demogines, A. (Ann), Wong, A. (Alex), Aquadro, C. (Charles), and Alani, E. (Eric)

Abstract

Genetic background effects underlie the penetrance of most genetically determined phenotypes, including human diseases. To explore how such effects can modify a mutant phenotype in a genetically tractable system, we examined an incompatibility involving the MLH1 and PMS1 mismatch repair genes using a large population sample of geographically and ecologically diverse Saccharomyces cerevisiae strains. The mismatch repair incompatibility segregates into naturally occurring yeast strains, with no strain bearing the deleterious combination. In assays measuring the mutator phenotype conferred by different combinations of MLH1 and PMS1 from these strains, we observed a mutator phenotype only in combinations predicted to be incompatible. Surprisingly, intragenic modifiers could be mapped that specifically altered the strength of the incompatibility over a 20-fold range. Together, these observations provide a powerful model in which to understand the basis of disease penetrance and how such genetic variation, created through mating, could result in new mutations that could be the raw material of adaptive evolution in yeast populations.

Published
2008
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50. Evolution at the tip and base of the X chromosome in an African population of Drosophila melanogaster.

Author

Begun, D J and Aquadro, C F

Abstract

Hitchhiking effects of advantageous mutations have been invoked to explain reduced polymorphism in regions of low crossing-over in Drosophila. Besides reducing DNA heterozygosity, hitchhiking effects should produce strong linkage disequilibrium and a frequency spectrum skewed toward an excess of rare polymorphisms (compared to the neutral expectation). We measured DNA polymorphism in a Zimbabwe population of D. melanogaster at three loci, yellow, achaete, and suppressor of forked, located in regions of reduced crossing-over. Similar to previously published surveys of these genomic regions in other populations, we observed low levels of nucleotide variability. However, the frequency spectrum was compatible with a neutral model, and there was abundant evidence for recombination in the history of the yellow and ac genes. Thus, some aspects of the data cannot be accounted for by a simple hitchhiking model. An alternative hypothesis, background selection, might be compatible with the observed patterns of linkage disequilibrium and the frequency spectrum. However, this model cannot account for the observed reduction in nucleotide heterozygosity. Thus, there is currently no satisfactory theoretical model for the data from the tip and base of the X chromosome in D. melanogaster.

Published
1995
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