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191 results on '"Appetecchia, M"'

1. Gender-related differences in patients with carcinoid syndrome: new insights from an Italian multicenter cohort study

Author

Ruggeri, R. M., Altieri, B., Razzore, P., Retta, F., Sperti, E., Scotto, G., Brizzi, M. P., Zumstein, L., Pia, A., Lania, A., Lavezzi, E., Nappo, G., Laffi, A., Albertelli, M., Boschetti, M., Hasballa, I., Veresani, A., Prinzi, N., Pusceddu, S., Oldani, S., Nichetti, F., Modica, R., Minotta, R., Liccardi, A., Cannavale, G., Grossrubatscher, E. M., Tarsitano, M. G., Zamponi, V., Zatelli, M. C., Zanata, I., Mazzilli, R., Appetecchia, M., Davì, M. V., Guarnotta, V., Giannetta, E., La Salvia, A., Fanciulli, G., Malandrino, P., Isidori, A. M., Colao, A., and Faggiano, A.

Published
2024
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2. When one size does not fit all: Reconsidering PCOS etiology, diagnosis, clinical subgroups, and subgroup-specific treatments

Author

Unfer, V., Kandaraki, E., Pkhaladze, L., Roseff, S., Vazquez-Levin, M.H., Laganà, A.S., Shiao-Yng, C., Yap-Garcia, M.I.M., Greene, N.D.E., Soulage, C.O., Bevilacqua, A., Benvenga, S., Barbaro, D., Pintaudi, B., Wdowiak, A., Aragona, C., Kamenov, Z., Appetecchia, M., Porcaro, G., Hernandez Marin, I., Facchinetti, F., Chiu, T., Pustotina, O., Papalou, O., Nordio, M., Cantelmi, T., Cavalli, P., Vucenik, I., D'Anna, R., Unfer, V.R., Dinicola, S., Salehpour, S., Stringaro, A., Montaninno Oliva, M., Tugushev, M., Prapas, N., Bizzarri, M., Espinola, M.S.B., Di Lorenzo, C., Ozay, A.C., and Nestler, J.

Published
2024
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6. Clinical cure vs a novel trifecta system for evaluating long-term outcomes of minimally-invasive partial or total adrenalectomy for unilateral primary aldosteronism: results of a multicentric series

Author

Anceschi, U., primary, Mormando, M., additional, Fiori, C., additional, Carrara, A., additional, Zappalà, O., additional, De Concilio, B., additional, Brassetti, A., additional, Bove, A.M., additional, Misuraca, L., additional, Tuderti, G., additional, Mastroianni, R., additional, Ferriero, M.C., additional, Appetecchia, M., additional, Tirone, G., additional, Porpiglia, F., additional, Celia, A., additional, Gallucci, M., additional, Guaglianone, S., additional, and Simone, G., additional

Published
2022
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7. A0625 - Clinical cure vs. a novel trifecta system for evaluating long-term outcomes of minimally-invasive partial or total adrenalectomy for unilateral primary aldosteronism: Results of a multicentric series

Author

Anceschi, U., Mormando, M., Fiori, C., Zappalà, O., De Concilio, B., Brassetti, A., Tuderti, G., Ferriero, M.C., Misuraca, L., Bove, A.M., Mastroianni, R., Carrara, A., Appetecchia, M., Porpiglia, F., Celia, A., Gallucci, M., Tirone, G., and Simone, G.

Published
2022
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8. 1111P New prognostic frontiers for lung neuroendocrine tumors: An Italian-Spanish multicentric study of 200 cases

Author

La Salvia, A., primary, Persano, I., additional, Verrico, M., additional, Bassi, M., additional, Modica, R., additional, Audisio, A., additional, Puliani, G., additional, Rinzivillo, M., additional, Zanata, I., additional, Baldelli, R., additional, Razzore, P., additional, Panzuto, F., additional, Volante, M., additional, Giannetta, E., additional, Appetecchia, M., additional, Zatelli, M.C., additional, Colao, A., additional, Brizzi, M.P., additional, Garcia-Carbonero, R., additional, and Faggiano, A., additional

Published
2021
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9. 1750P Molecular genotyping in refractory thyroid cancers: Results of a European survey

Author

Fouchardiere, C. de la, primary, Fugazzola, L., additional, Taylor, J., additional, Appetecchia, M., additional, Besic, N., additional, Bongiovanni, A., additional, Buffet, C., additional, Costante, G., additional, Gay, S., additional, Grande, E., additional, Kapiteijn, E., additional, Krajewska, J., additional, Kroiss, M., additional, Morreau, H., additional, Netea-Maier, R., additional, Peeters, R., additional, Soares, P., additional, Sykiotis, G., additional, Blay, J-Y., additional, and Locati, L.D., additional

Published
2021
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11. The TIS score for the prediction of long-term clinical outcomes after minimally-invasive partial and total adrenalectomy for unilateral primary aldosteronism: Results of a multicentric series

Author

Anceschi, U., primary, Mormando, M., additional, Fiori, C., additional, Zappalà, O., additional, De Concilio, B., additional, Brassetti, A., additional, Carrara, A., additional, Ferriero, M.C., additional, Tuderti, G., additional, Misuraca, L., additional, Bove, A.M., additional, Mastroianni, R., additional, Appetecchia, M., additional, Tirone, G., additional, Porpiglia, F., additional, Celia, A., additional, Gallucci, M., additional, and Simone, G., additional

Published
2021
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12. Surgical quality, antihypertensive therapy and electrolyte balance: A novel trifecta for evaluating outcomes of unilateral primary aldosteronism

Author

Anceschi, U., primary, Mormando, M., additional, Fiori, C., additional, Zappalà, O., additional, De Concilio, B., additional, Brassetti, A., additional, Carrara, A., additional, Ferriero, M.C., additional, Tuderti, G., additional, Misuraca, L., additional, Bove, A.M., additional, Mastroianni, R., additional, Appetecchia, M., additional, Tirone, G., additional, Porpiglia, F., additional, Celia, A., additional, Gallucci, M., additional, and Simone, G., additional

Published
2021
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13. How gender influence the health state? A cross sectional study in an endocrine setting

Author

Lauretta R, Appetecchia M, Barnabei A, Chiefari A, Terrenato I, Mormando M, Puliani G, and Bianchini M

Subjects
Cross-sectional study, Environmental health, Endocrine system, Psychology
Abstract

Background: Gender medicine focuses on how gender differences affect health status and diseases development and how they influence health services access and attitude to screening programmes. Endocrine diseases are influenced by many gender-related issues, some of which have not been sufficiently investigated. The aim of this study was to evaluate gender difference in determinants of health (as lifestyle, level of education, area of origin, distance from hospital) and how these elements could influence diseases prevalence in an endocrine outpatients setting, with a special focus on oncological disease. Methods: We performed a cross-sectional study enrolling patients referring for the first time to our Oncological Endocrinology Unit, between January 2019 to December 2019. Results: We enrolled 1107 consecutive patients. Mean age was 56.8 ± 15.0 years (77% females). The main reasons for referral were thyroid and bone diseases. We found a gender difference in some disease prevalences: malignant endocrine diseases and iatrogenic thyroid diseases were more frequent in males, while other thyroid disorders, adrenal and metabolic diseases and cancer treatment induced bone loss were higher in females. The frequency of oncological comorbidities was higher in females. No difference was found in the propensity to travel long distances to reach the hospital. In our population, women had a higher socio-cultural level and followed healthier lifestyle. In fact, alcohol and tobacco consumption was lower in females and women had lower BMI. The percentage of smokers or ex-smokers was higher in patients with any malignancy compared to patients with benign endocrine diseases. Conclusions: the study showed the importance of considering gender as a determinant of health, able to influence also lifestyle and habits, and as an element to keep in consideration to promote a healthier lifestyle and a targeted endocrine screening especially in oncological setting.

Published
2020
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15. Gender-related differences in patients with carcinoid syndrome: new insights from an Italian multicenter cohort study

Author

Ruggeri, R. M., Altieri, B., Razzore, P., Retta, F., Sperti, E., Scotto, G., Brizzi, M. P., Zumstein, L., Pia, A., Lania, A., Lavezzi, E., Nappo, G., Laffi, A., Albertelli, M., Boschetti, M., Hasballa, I., Veresani, A., Prinzi, N., Pusceddu, S., Oldani, S., Nichetti, F., Modica, R., Minotta, R., Liccardi, A., Cannavale, G., Grossrubatscher, E. M., Tarsitano, M. G., Zamponi, V., Zatelli, M. C., Zanata, I., Mazzilli, R., Appetecchia, M., Davì, M. V., Guarnotta, V., Giannetta, E., La Salvia, A., Fanciulli, G., Malandrino, P., Isidori, A. M., Colao, A., and Faggiano, A.

Abstract

Background: The incidence of neuroendocrine neoplasm (NEN) and related carcinoid syndrome (CaS) has increased markedly in recent decades, and women appear to be more at risk than men. As per other tumors, gender may be relevant in influencing the clinical and prognostic characteristics of NEN-associated CS. However, specific data on carcinoid syndrome (CaS) are still lacking. Purpose: To evaluate gender differences in clinical presentation and outcome of CaS. Methods: Retrospective analysis of 144 CaS patients from 20 Italian high-volume centers was conducted. Clinical presentation, tumor characteristics, therapies, and outcomes (progression-free survival, PFS, overall survival, OS) were correlated to gender. Results: Ninety (62.5%) CaS patients were male. There was no gender difference in the site of primary tumor, tumor grade and clinical stage, as well as in treatments. Men were more frequently smokers (37.2%) and alcohol drinkers (17.8%) than women (9.5%, p= 0.002, and 3.7%, p= 0.004, respectively). Concerning clinical presentation, women showed higher median number of symptoms (p= 0.0007), more frequent abdominal pain, tachycardia, and psychiatric disorders than men (53.3% vs 70.4%, p= 0.044; 6.7% vs 31.5%, p= 0.001; 50.9% vs. 26.7%, p= 0.003, respectively). Lymph node metastases at diagnosis were more frequent in men than in women (80% vs 64.8%; p= 0.04), but no differences in terms of PFS (p= 0.51) and OS (p= 0.64) were found between gender. Conclusions: In this Italian cohort, CaS was slightly more frequent in males than females. Gender-related differences emerged in the clinical presentation of CaS, as well as gender-specific risk factors for CaS development. A gender-driven clinical management of these patients should be advisable.

Published
2023
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18. An update on the use of inositols in preventing gestational diabetes mellitus (GDM) and neural tube defects (NTDs)

Author

Facchinetti, F, Cavalli, P, Copp, Aj, D'Anna, R, Kandaraki, E, Greene, Nde, Unfer, V, Experts Group on Inositol in Basic and Clinical Research (Facchinetti, F, Appetecchia, M, Aragona, C, Bertelli, M, Bevilacqua, A, Bezerra Espinola MS, Bizzarri, M, Copp, A, D’Anna, R, Dewailly, D, Greene, N, Hernández Marín, I, Kamenov, Za, Diamanti-Kandarakis, E, Laganà, As, Monastra, G, Montanino Oliva, M, Nestler, Je, Ozay, Ac, Papalou, O, Pkhaladze, L, Porcaro, G, Prapas, N, Soulage, Co, Stringaro, A, Vazquez-Levin, M, and Wdowiak, A

Subjects
medicine.medical_specialty, endocrine system diseases, D-chiro-inositol (DCI), medicine.medical_treatment, Toxicology, 030226 pharmacology & pharmacy, Article, gestational diabetes mellitus (GDM), 03 medical and health sciences, 0302 clinical medicine, Insulin resistance, prevention, Pregnancy, insulin resistance, Medicine, Animals, Humans, Insulin, Neural Tube Defects, neural tube defects (NTDs), Pharmacology, Fetus, business.industry, Obstetrics, Diabetes, Neural tube, Infant, Newborn, nutritional and metabolic diseases, Infant, General Medicine, medicine.disease, Newborn, Gestational diabetes, Diabetes, Gestational, myo-inositol (MI), medicine.anatomical_structure, 030220 oncology & carcinogenesis, Obstetric history, Gestational, Female, Inositol, business, Maternal body
Abstract

INTRODUCTION: Obstetric history and maternal body composition and lifestyle may be associated with serious complications both for the mother, such as gestational diabetes mellitus (GDM), and for the fetus, including congenital malformations such as neural tube defects (NTDs). AREAS COVERED: In view of the recent knowledge, changes of nutritional and physical activity habits ameliorate glycemic control during pregnancy and in turn improve maternal and neonatal health outcomes. Recently, a series of small clinical and experimental studies indicated that supplementation with inositols, a family of insulin sensitizers, was associated with beneficial impact for both GDM and NTDs. EXPERT OPINION: Herein, we discuss the most significant scientific evidence supporting myo-inositol administration as a prophylaxis for the above-mentioned conditions.

Published
2020

20. Epidemiology of Simultaneous Medullary and Papillary Thyroid Carcinomas (MTC/PTC): An Italian Multicenter Study

Author

Appetecchia, M., Lauretta, R., Barnabei, A., Pieruzzi, L., Terrenato, I., Cavedon, E., Mian, C., Castagna, M. G., Elisei, R., Mariotti, S, Fugazzola, L, Orlandi, F, Romei, C, Pani, F, Calanchini, M, Loli, P, Limone, P, Seregni, E, Durante, C, Isidori, Am, Van Doorne, D, Fabbri, A, Filetti, S, Pacini, F, and Giacomelli, L.

Subjects
Cancer Research, medicine.medical_specialty, Medullary cavity, endocrine system diseases, 030209 endocrinology & metabolism, lcsh:RC254-282, Gastroenterology, medullary thyroid cancer, Article, Papillary thyroid cancer, Thyroid carcinoma, 03 medical and health sciences, 0302 clinical medicine, hemic and lymphatic diseases, Internal medicine, Epidemiology, medicine, papillary thyroid cancer, Stage (cooking), business.industry, Medullary thyroid cancer, respiratory system, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Confidence interval, Oncology, 030220 oncology & carcinogenesis, Concomitant, epidemiology, business
Abstract

Background: The concomitant presence of papillary thyroid cancer (PTC) and medullary TC (MTC) is rare. In this multicentric study, we documented the epidemiological characteristics, disease conditions and clinical outcome of patients with simultaneous MTC/PTC. Methods: We collected data of patients with concomitant MTC/PTC at 14 Italian referral centers. Results: In total, 183 patients were enrolled. Diagnosis was mostly based on cytological examination (n = 58, 32%). At diagnosis, in the majority of cases, both PTC (n = 142, 78%) and MTC (n = 100, 54%) were at stage I. However, more cases of stage II–IV were reported with MTC (stage IV: n = 27, 15%) compared with PTC (n = 9, 5%). Information on survival was available for 165 patients: 109 patients (66%) were disease-free for both PTC and MTC at the last follow-up. Six patients died from MTC. Median time to progression was 123 months (95% confidence interval (CI): 89.3–156.7 months). Overall, 45% of patients were disease-free after &gt, 10 years from diagnosis (125 months), this figure was 72.5% for PTC and 51.1% for MTC. Conclusions: When MTC and PTC are concurrent, the priority should be given to the management of MTC since this entity appears associated with the most severe impact on prognosis.

Published
2019
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22. SC181 - Clinical cure vs a novel trifecta system for evaluating long-term outcomes of minimally-invasive partial or total adrenalectomy for unilateral primary aldosteronism: results of a multicentric series

Author

Anceschi, U., Mormando, M., Fiori, C., Carrara, A., Zappalà, O., De Concilio, B., Brassetti, A., Bove, A.M., Misuraca, L., Tuderti, G., Mastroianni, R., Ferriero, M.C., Appetecchia, M., Tirone, G., Porpiglia, F., Celia, A., Gallucci, M., Guaglianone, S., and Simone, G.

Published
2022
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23. Acromegaly is associated with increased cancer risk: a survey in Italy

Author

Terzolo, Massimo, Reimondo, Giuseppe, Berchialla, Paola, FERRANTE, EMANUELE, Malchiodi, Elena, De Marinis, Laura, Pivonello, Rosario, Grottoli, Silvia, Losa, Marco, Cannavo, Salvatore, Ferone, Diego, Montini, Marcella, Bondanelli, Marta, De Menis, Ernesto, Martini, Chiara, Puxeddu, Efisio, Velardo, Antonino, Peri, Alessandro, Faustini-Fustini, Marco, Tita, Patrizia, Pigliaru, Francesca, Peraga, Giulia, Borretta, Giorgio, Scaroni, Carla, Bazzoni, Nicoletta, Bianchi, Antonio, Berton, Alessandro, Serban, Andreea Liliana, Baldelli, Roberto, Fatti, Letizia Maria, Colao, Annamaria, Arosio, Maura, Lombardi, G., TRIMARCHI, LORENZO, Degli Uberti, E. C., Ambrosio, M. R., Pagani, G., Attanasio, R., Kara, E., Mantero, F., Ceccato, F., Mortini, P., Razzore, P., Angeletti, G., Della Torre, D., Mariotti, S., Ghigo, E., Mainini, A. L., Appetecchia, M., Vigneri, R., Minuto, F., Nazzari, E., Cavagnini, F., Persani, L., Terzolo, Massimo, Reimondo, Giuseppe, Berchialla, Paola, Ferrante, Emanuele, Malchiodi, Elena, De Marinis, Laura, Pivonello, Rosario, Grottoli, Silvia, Losa, Marco, Cannavo, Salvatore, Ferone, Diego, Montini, Marcella, Bondanelli, Marta, De Menis, Ernesto, Martini, Chiara, Puxeddu, Efisio, Velardo, Antonino, Peri, Alessandro, Faustini-Fustini, Marco, Tita, Patrizia, Pigliaru, Francesca, Peraga, Giulia, Borretta, Giorgio, Scaroni, Carla, Bazzoni, Nicoletta, Bianchi, Antonio, Berton, Alessandro, Serban, Andreea Liliana, Baldelli, Roberto, Fatti, Letizia Maria, Colao, Annamaria, Arosio, Maura for the Italian Study Group of Acromegaly, Arosio, Maura, Lombardi, G., Trimarchi, Lorenzo, Degli Uberti, E. C., Ambrosio, M. R., Pagani, G., Attanasio, R., Kara, E., Mantero, F., Ceccato, F., Mortini, P., Razzore, P., Angeletti, G., Della Torre, D., Mariotti, S., Ghigo, E., Mainini, A. L., Appetecchia, M., Vigneri, R., Minuto, F., Nazzari, E., Cavagnini, F., and Persani, L.

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Colorectal cancer, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, NO, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Risk Factors, Neoplasms, Internal medicine, Gh IGF1, Acromegaly, Humans, Medicine, cancer, Family history, Thyroid cancer, Acromegaly cancer, Oncology, business.industry, GH, IGF1, acromegaly, Incidence, Risk Factor, Incidence (epidemiology), Cancer, Middle Aged, medicine.disease, Diabetes and Metabolism, Acromegaly, cancer, GH, IGF1, Italy, 030220 oncology & carcinogenesis, Neoplasm, Female, Cohort Studie, business, Kidney cancer, Human, Cohort study
Abstract

It is debated if acromegalic patients have an increased risk to develop malignancies. The aim of the present study was to assess the standardized incidence ratios (SIRs) of different types of cancer in acromegaly on a large series of acromegalic patients managed in the somatostatin analogs era. It was evaluated the incidence of cancer in an Italian nationwide multicenter cohort study of 1512 acromegalic patients, 624 men and 888 women, mean age at diagnosis 45 ± 13 years, followed up for a mean of 10 years (12573 person-years) in respect to the general Italian population. Cancer was diagnosed in 124 patients, 72 women and 52 men. The SIRs for all cancers was significantly increased compared to the general Italian population (expected: 88, SIR 1.41; 95% CI, 1.18–1.68, P P = 0.022), kidney cancer (SIR 2.87; 95% CI, 1.55–5.34, P P

Published
2017

25. Gender in Endocrine Diseases: Role of Sex Gonadal Hormones

Author

Lauretta, R., Sansone, M., Sansone, A., Romanelli, F., and Appetecchia, M.

Subjects
Article Subject
Abstract

Gender- and sex- related differences represent a new frontier towards patient-tailored medicine, taking into account that theoretically every medical specialty can be influenced by both of them. Sex hormones define the differences between males and females, and the different endocrine environment promoted by estrogens, progesterone, testosterone, and their precursors might influence both human physiology and pathophysiology. With the term Gender we refer, instead, to behaviors, roles, expectations, and activities carried out by the individual in society. In other words, “gender” refers to a sociocultural sphere of the individual, whereas “sex” only defines the biological sex. In the last decade, increasing attention has been paid to understand the influence that gender can have on both the human physiology and pathogenesis of diseases. Even the clinical response to therapy may be influenced by sex hormones and gender, but further research is needed to investigate and clarify how they can affect the human pathophysiology. The path to a tailored medicine in which every patient is able to receive early diagnosis, risk assessments, and optimal treatments cannot exclude the importance of gender. In this review, we have focused our attention on the involvement of sex hormones and gender on different endocrine diseases.

Published
2018
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26. P0686 - The TIS score for the prediction of long-term clinical outcomes after minimally-invasive partial and total adrenalectomy for unilateral primary aldosteronism: Results of a multicentric series

Author

Anceschi, U., Mormando, M., Fiori, C., Zappalà, O., De Concilio, B., Brassetti, A., Carrara, A., Ferriero, M.C., Tuderti, G., Misuraca, L., Bove, A.M., Mastroianni, R., Appetecchia, M., Tirone, G., Porpiglia, F., Celia, A., Gallucci, M., and Simone, G.

Published
2021
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28. Predittori di morbilità e mortalità nell’acromegalia: studio italiano del Gruppo di Studio sull’Acromegalia

Author

Arosio, M., Reimondo, G., Malchiodi, E., Berchialla, P., Borraccino, A., De Marinis, L., Oivonello, R., Grotoli, S., Losa, M., Cannavò, S., Minuto, F., Montini, M., Bondanelli, M., De Menis, E., Martini, C., Angeletti, G., Velardo, A., Peri, A., Faustini-Fustini, M., Tita, P., Pigliaru, F., Borretta, G., Scaroni, C., Bazzoni, N., Bianchi, A., Appetecchia, M., Cavagnini, F., Lombardi, G., Ghigo, E., Peccoz, P. Peck, Colao, A., Terzolo, M., Arvat, Emanuela, and Gruppo di Studio Italiano sull’Acromegalia

Published
2012
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29. Real-world study of everolimus in advanced progressive neuroendocrine tumors

Author

Panzuto F, Rinzivillo M, Fazio N, de Braud F, Luppi G, Zatelli MC, Lugli F, Tomassetti P, Riccardi F, Nuzzo C, Brizzi MP, Faggiano A, Zaniboni A, Nobili E, Pastorelli D, Cascinu S, Merlano M, Chiara S, Antonuzzo L, Funaioli C, Spada F, Pusceddu S, Fontana A, Ambrosio MR, Cassano A, Campana D, Cartenì G, Appetecchia M, Berruti A, Colao A, Falconi M, Panzuto, F, Rinzivillo, M, Fazio, N, de Braud, F, Luppi, G, Zatelli, Mc, Lugli, F, Tomassetti, P, Riccardi, F, Nuzzo, C, Brizzi, Mp, Faggiano, A, Zaniboni, A, Nobili, E, Pastorelli, D, Cascinu, S, Merlano, M, Chiara, S, Antonuzzo, L, Funaioli, C, Spada, F, Pusceddu, S, Fontana, A, Ambrosio, Mr, Cassano, A, Campana, D, Cartenì, G, Appetecchia, M, Berruti, A, Colao, A, and Falconi, M

Published
2015

32. Tumore neuroendocrino ileale e metastasi epatiche

Author

Baldelli, R., Rizza, Laura, DI GIACINTO, Paola, Barnabei, A., Rota, F., Paoloni, A., Battocchio, M., Isidori, Andrea, Appetecchia, M., Lenzi, Andrea, and Martini, C.

Subjects
alte dosi, octreotide LAR, analoghi della somatostatina (SSA), tumori neuroendocrini, terapia
Published
2013

35. Assessment of the awareness and management of sleep apnea syndrome in acromegaly. The COM.E.TA (Comorbidities Evaluation and Treatment in Acromegaly) Italian Study Group

Author

Menis, E., Giustina, A., Colao, A., Degli Uberti, E., Ghigo, E., Minuto, F., Bogazzi, F., Drigo, R., Cattaneo, A., Aimaretti, G., Ambrosio, M. R., Andreani, M., Angeletti, G., Celleno, R., Appetecchia, M. L., Baldelli, R., Armigliato, M., Arosio, M., Babini, A., Baldi, F., Balza, G., Bartalena, L., Tanda, M. L., Battista, C., Beck-Peccoz, P., Boffano, G. M., Martino, E., Borboni, P., Borretta, G., Baffoni, C., Boscaro, M., Arnaldi, G., Buschini, M., Salvatore Cannavo, Caramellino, A., Carani, C., Castelli, A., Pancotti, M., Cavagnini, F., Chiodera, P., Cataldo, S., Chiovato, L., Colombo, M., Crivellaro, C., D Ulizia, M., Mattè, S., Del Monte, P., Delitala, G., Masala, A., Fabbri, A., Piantoni, L., Faustini Fustini, M., Favro, S., Ferone, D., Fidotti, E., Valentini, F., Formoso, G., Frigato, F., Furlani, L., Gargiulo, P., Gasparoni, P., Gazzaruso, C., Giordano, C., Giorgino, F., Grandi, M., Pedersoli, S., Grimaldi, F., Grottoli, S., La Grotta, A., Lanzi, R., Limone, P., Razzore, P., Lio, S., Lo Cascio, V., Francia, G., Davì, M. V., Lo Coco, R., Macinini, E., Mantero, F., Scaroni, C., Marchetti, M., Mariotti, S., Pigliaru, F., Marzullo, P., Monachesi, M., Montini, M., Pagani, G., Muggeo, M., Castello, R., Mulas, G., Nassi, R., Vezzosi, C., Nizzoli, M., Orlandi, F., Pacini, F., Di Cairano, G., Palermo, M., Paoletta, A., Papini, E., Parillo, M., Parisi, G., Pasquali, R., Pagotto, U., Pavoncello, S., Perego, M. R., Peri, A., Piscopello, L., Pivonello, R., Raffa, M., Raggiunti, B., Roiter, I., Tamburrano, G., Terzolo, M., Testa, I., Testori, G., Cerruti, N., Toscano, V., Tota, N., Vailati, A., Lovati, E., Valcavi, R., Vincenzi, V., De Menis, E, Giustina, A, Colao, A, Degli Uberti, E, Ghigo, E, Minuto, F, Bogazzi, F, Drigo, R, Cattaneo, A, Aimaretti, G, Giordano, C, Giustina, Andrea, Italian Study Group, C. O. M. E. T. A., De Menis, E., Giustina, A., Colao, A., Degli Uberti, E., Ghigo, E., Minuto, F., Bogazzi, F., Drigo, R., Cattaneo, A., Aimaretti, G., Ambrosio, M.R., Andreani, M., Angeletti, G., Celleno, R., Appetecchia, M.L., Baldelli, R., Armigliato, M., Arosio, M., Babini, A., Baldi, F., Balza, G., Bartalena, L., Tanda, M.L., Battista, C., Beck-Peccoz, P., Boffano, G.M., Martino, E., Borboni, P., Borretta, G., Baffoni, C., Boscaro, M., Arnaldi, G., Buschini, M., Cannavò, S., Caramellino, A., Carani, C., Castelli, A., Pancotti, M., Cavagnini, F., Chiodera, P., Cataldo, S., Chiovato, L., Colombo, M., Crivellaro, C., D'Ulizia, M., De Mattè, S., Del Monte, P., Delitala, G., Masala, A., Fabbri, A., Piantoni, L., Faustini Fustini, M., Favro, S., Ferone, D., Fidotti, E., Valentini, F., Formoso, G., Frigato, F., Furlani, L., Gargiulo, P., Gasparoni, P., Gazzaruso, C., Giordano, C., Giorgino, F., Grandi, M., Pedersoli, S., Grimaldi, F., Grottoli, S., La Grotta, A., Lanzi, R., Limone, P., Razzore, P., Lio, S., Lo Cascio, V., Francia, G., Davì, M.V., Lo Coco, R., Macinini, E., Mantero, F., Scaroni, C., Marchetti, M., Mariotti, S., Pigliaru, F., Marzullo, P., Monachesi, M., Montini, M., Pagani, G., Muggeo, M., Castello, R., Mulas, G., Nassi, R., Vezzosi, C., Nizzoli, M., Orlandi, F., Pacini, F., Di Cairano, G., Palermo, M., Paoletta, A., Papini, E., Parillo, M., Parisi, G., Pasquali, R., Pagotto, U., Pavoncello, S., Perego, M.R., Peri, A., Piscopello, L., Pivonello, R., Raffa, M., Raggiunti, B., Roiter, I., Tamburrano, G., Terzolo, M., Testa, I., Testori, G., Cerruti, N., Toscano, V., Tota, N., Vailati, A., Lovati, E., Valcavi, R., Vincenzi, V., Colao, Annamaria, and C. O. M. E. T. A. Italian Study G. r. o. u., P.

Subjects
Male, Pediatrics, medicine.medical_specialty, medicine.medical_treatment, Endocrinology, Diabetes and Metabolism, Polysomnography, Comorbidity, somatostatin analogs, acromegaly, sleep apnea syndrome, Settore MED/13 - Endocrinologia, Somatostatin analog, Endocrinology, Sleep Apnea Syndromes, Quality of life, Acromegaly, Sleep apnea syndrome, Somatostatin analogs, Physicians, Surveys and Questionnaires, medicine, Prevalence, Humans, Continuous positive airway pressure, medicine.diagnostic_test, business.industry, Sleep apnea, Awareness, Focus Groups, sleep apnea, medicine.disease, Sleep Apnea, Italy, Physical therapy, COM.E.TA, Female, Clinical Competence, business
Abstract

In 2007 the Italian COM.E.T.A. (COMorbidities Evaluation and Treatment in Acromegaly) study group started to assess the application in a clinical setting of the Versailles criteria for management of acromegaly complications by a first questionnaire focusing on cardiovascular co-morbidities. A further questionnaire on sleep apnea syndrome (SAS) was delivered by the COM.E.T.A. study group to 107 endocrine centers in Italy. The results of our survey suggest that SAS is a well-known comorbidity even if its estimated prevalence is lower than in the literature. Polysomnography is the preferred tool for diagnosis. Control of SAS is considered relevant both for quality of life and co-morbidities. Continuous positive airway pressure is the cornerstone of therapy, but patients' acceptance may be critical. Control of GH/IGF-I secretion is important to improve SAS. Management of SAS requires cooperation between specialists. ©2011, Editrice Kurtis.

Published
2011

36. Hurthle cell tumours of the thyroid. Personal experience and review of the literature

Author

Agnese Barnabei, Ferretti, E., Baldelli, R., Procaccini, A., Spriano, G., and Appetecchia, M.

Subjects
Adult, Male, Adenoma, Oxyphilic, Humans, Female, Thyroid Neoplasms, Original Articles, Middle Aged, Prognosis, Aged, Retrospective Studies
Abstract

Hurthle cell carcinoma represents about 5% of differentiated thyroid carcinomas. The prognosis of the malignant type of the tumour is still under debate as some Authors have reported that Hurthle cell adenoma occasionally behaves like Hurthle cell carcinoma. Aim of the present study was to evaluate previously reported data and personal experience on the clinical and pathological features of patients affected by Hurthle cell tumour that may predict disease progression and death. In the literature, factors potentially associated with decreased survival were identified and include: age, disease stage, tumour size, extra-glandular invasion, lymph node disease, distant metastases, extensive surgery, radioiodine treatment. From 1992 to 2003, the Authors identified 28 patients affected by Hurthle cell tumour, 9 with Hurthle cell adenoma and 19 with Hurthle cell carcinoma. Of these, 22 were females and 6 males. Mean age of patients affected by adenoma was 49.7 years (range 30-72) vs. 49.3 years (range 15-72) in Hurthle cell carcinoma patients. In all patients, total thyroidectomy was performed. At histology, 9 adenomas, 5 "minimally invasive" and 14 invasive carcinomas were found. Post-operatively, in Hurthle cell carcinoma patients, TNM staging showed 9 patients with stage I, 5 stage II, 4 stage III and one stage IVa (UICC, 2002). All invasive carcinomas underwent (131)I therapy (91-585 mCi). One Hurthle cell carcinoma patient received external beam radiotherapy. The mean follow-up period was 62 months (range 6-324). Relapse was not observed in any of the cases with adenoma. Only one Hurthle cell carcinoma patient showed distant lung metastases at 60 months' follow-up. In conclusion, Hurthle cell carcinoma was not found to present a more aggressive behaviour than follicular carcinoma, when risk factors, including extent of tumour invasion, were taken into account. None of the patients with Hurthle cell adenoma showed a relapse or death caused by the tumour.

Published
2009

37. Assessment of the awareness and management of cardiovascular complications of acromegaly in Italy. The COM.E.T.A. (COMorbidities Evaluation and Treatment in Acromegaly) Study

Author

Giustina, A., Mancini, T., Boscani, P. F., De Menis, E., Degli Uberti, E., Ghigo, E., Martino, E., Minuto, F., Colao, A., Comorbidities Evaluation, Com E. T. A., Treatment Inacromegaly Italian Study Group, Aimaretti, G., Ambrosio, M. R., Andreani, M., Angeletti, G., Appetecchia, M. L., Armigliato, M., Arnaldi, G., Arosio, M., Babini, A., Baldi, F., Balza, G., Barbaro, D., Bartalena, L., Battista, C., Bechi, R., Beck Peccoz, P., Bellastella, A., Bevilacqua, M., Boccuzzi, G., Boffano, G. M., Bondanelli, M., Borretta, G., Boscaro, M., Buschini, M., Campanini, M., Cannavo, S., Carani, C., Carpenito, F., Carzaniga, C., Castelli, A., Cavagnini, F., Chiarini, V., Chiodera, P., Colombo, M., Colombo, P., Coppola, A., Cozzi, R., Crivellaro, C., D'Antonio, R., Davi, M., De Marinis, L., De Matte, S., De Remigis, P., Del Monte, P., Delitala, G., Doveri, G., D'Ulizia, M., Favro, S., Ferone, D., Fidotti, E., Formoso, G., Francia, G., Frigato, F., Furlani, L., Galuzzo, A., Gargiulo, P., Gasperoni, P., Gazzaruso, C., Giorgino, F., Grandi, M., Grimaldi, F., Indovina, S., Lanzi, R., Legovini, P., Limone, P., Liuzzi, A., Lo Cascio, V., Lo Coco, R., Loli, P., Mantero, F., Marchetti, M., Mariotti, S., Masala, A., Meringolo, D., Monachesi, M., Montini, M., Moretti, C., Muggeo, M., Mulas, G., Nizzolo, M., Oleandri, S., Orio, F., Orlandi, F., Pacini, F., Palermo, M., Pancotti, D., Paoletta, A., Papini, E., Parillo, M., Parisi, G., Pasquali, R., Pavoncello, S., Perego, M. R., Peri, A., Peri, D., Piantoni, L., Raffa, M., Raggiunti, B., Resmini, E., Rizzi, G., Rosatello, A., Rosato, F., Savino, L., Scaroni, C., Sinisi, A., Stefani, I., Tamburrano, G., Tanda, M., Terzolo, M., Testa, I., Testa, R., Testori, G., Toscano, Vincenzo, Tota, N., Travaglini, P., Vailati, A., Valcavi, R., Ventre, I., Vincenzi, W., Vitale, G., A., Giustina, T., Mancini, P. F., Boscani, E., de Meni, E., degli Uberti, E., Ghigo, E., Martino, F., Minuto, Colao, Annamaria, Giustina A, Mancini T, Boscani PF, de Menis E, degli Uberti E, Ghigo E, Martino E, Minuto F, Colao A, Aimaretti G, Ambrosio MR, Andreani M, Angeletti G, Appetecchia ML, Armigliato M, Arnaldi G, Arosio M, Babini A, Baldi F, Balza G, Barbaro D, Bartalena L, Battista C, Bechi R, Beck-Peccoz P, Bellastella A, Bevilacqua M, Boccuzzi G, Boffano GM, Bondanelli M, Borretta G, Boscaro M, Buschini M, Campanini M, Cannavò S, Carani C, Carpenito F, Carzaniga C, Castelli A, Cavagnini F, Chiarini V, Chiodera P, Colombo M, Colombo P, Coppola A, Cozzi R, Crivellaro C, D'Antonio R, Davì M, De Marinis L, De Mattè S, De Remigis P, Del Monte P, Delitala G, Doveri G, D'Ulizia M, Favro S, Ferone D, Fidotti E, Formoso G, Francia G, Frigato F, Furlani L, Galuzzo A, Gargiulo P, Gasperoni P, Gazzaruso C, Giorgino F, Grandi M, Grimaldi F, Indovina S, Lanzi R, Legovini P, Limone P, Liuzzi A, Lo Cascio V, Lo Coco R, Loli P, Mantero F, Marchetti M, Mariotti S, Masala A, Meringolo D, Monachesi M, Montini M, Moretti C, Muggeo M, Mulas G, Nizzolo M, Oleandri S, Orio F, Orlandi F, Pacini F, Palermo M, Pancotti D, Paoletta A, Papini E, Parillo M, Parisi G, Pasquali R, Pavoncello S, Perego MR, Peri A, Peri D, Piantoni L, Raffa M, Raggiunti B, Resmini E, Rizzi G, Rosatello A, Rosato F, Savino L, Scaroni C, Sinisi A, Stefani I, Tamburrano G, Tanda M, Terzolo M, Testa I, Testa R, Testori G, Toscano V, Tota N, Travaglini P, Vailati A, Valcavi R, Ventre I, Vincenzi W, Vitale G., Giustina, Andrea, Mancini, T, Boscani, Pf, DE MENIS, E, DEGLI UBERTI, E, Ghigo, E, Martino, E, Minuto, F, Colao, A, and Italian Study Group, C. O. M. E. T. A.

Subjects
Questionnaires, cardiovascular risk, medicine.medical_specialty, Pathology, Ambulatory blood pressure, Cardiomyopathy, Endocrinology, Diabetes and Metabolism, MEDLINE, Disease, heart, Comorbidity, Left ventricular hypertrophy, NO, Endocrinology, Patient Education as Topic, Surveys and Questionnaires, Acromegaly, medicine, Humans, Intensive care medicine, Awareness, Echocardiography, Hypertension, Questionnaire, business.industry, Cardiovascular Diseases, Epidemiologic Studies, Follow-Up Studies, medicine.disease, Blood pressure, Heart failure, business
Abstract

Background: During the course of acromegaly, cardiovascular, respiratory, and metabolic co-morbidities contribute to enhanced mortality. In 2002, the Pituitary Society and the European Neuroendocrine Association sponsored a Consensus Workshop in Versailles during which guidelines for diagnosis and treatment of co-morbidities in acromegaly were defined. However, as for other guidelines previously issued in the field, no data are available on their clinical application. Aim: The aim of this work coordinated by the Italian Study group on co-morbidities evaluation and treatment in acromegaly (COM.E.T.A.) was to assess, on a national basis, the application in the clinical practice of the Versailles criteria for diagnosis and treatment of cardiovascular comorbities in acromegaly. Materials and methods: In January 2007 an ad hoc designed questionnaire was sent by mail to 130 endocrine Centers in Italy. Results: The guidelines have been generally well perceived and translated in clinical practice. Specifically: 1) echocardiography is considered the mainstay for the diagnosis and follow-up; 2) ambulatory blood pressure monitoring and blood lipid assessment are performed in most hypertensive patients; 3) most endocrinologists directly manage hypertension and are aware of the uncertainty of the effect of the control of the disease on blood pressure levels; 4) ACE inhibitors and angiotensin receptors blockers are first-choice anti-hypertensive treatment; 5) approximately half of the centers consider somatostatin analogues of paramount relevance for biochemical control of disease; 6) awareness that left ventricular hypertrophy and heart failure are the most relevant cardiovascular complications is high although the impact of ischemic, arrhythmic, and valvular complications on prognosis is less well perceived. Conclusion: The results of the present survey suggest that previuosly issued guidelines are generally carefully followed in the clinical practice. On the other side, a certain lack of awareness of emerging aspects of the cardiovascular comorbities of acromegaly confirms the necessity of periodically updating the guidelines based on the availability of new clinical information.

Published
2008

40. Somatostatin analogs therapy in gastroenteropancreatic neuroendocrine tumors: current aspects and new perspectives

Author

Baldelli, R, Barnabei, A, Rizza, L, Isidori, Am, Rota, F, Di Giacinto, P, Paoloni, A, Torino, F, Corsello, Salvatore Maria, Lenzi, A, Appetecchia, M., Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274), Baldelli, R, Barnabei, A, Rizza, L, Isidori, Am, Rota, F, Di Giacinto, P, Paoloni, A, Torino, F, Corsello, Salvatore Maria, Lenzi, A, Appetecchia, M., and Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274)

Abstract

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are rare tumors that present many clinical features secreting peptides and neuroamines that cause distinct clinical syndromes such as carcinoid syndrome. However most of them are clinically silent until late presentation with mass effects. Surgical resection is the first line treatment for a patient with a GEP-NET while in metastatic disease multiple therapeutic approaches are possible. GEP-NETs are able to express somatostatin receptors (SSTRs) bounded by somatostatin (SST) or its synthetic analogs, although the subtypes and number of SSTRs expressed are very variable. In particular, SST analogs are used frequently to control hormone-related symptoms while their anti-neoplastic activity seems to result prevalently in tumor stabilization. Patients who fail to respond or cease to respond to standard SST analogs treatment seem to have a response to higher doses of these drugs. For this reason, the use of higher doses of SST analogs will probably improve the clinical management of these patients.

Published
2014

41. Testicular and inguinal lymph node metastases of medullary thyroid cancer: a case report and review of the literature

Author

Appetecchia, M, Barnabei, A, Pompeo, V, Sentinelli, S, Baldelli, R, Corsello, Salvatore Maria, Torino, F., Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274), Appetecchia, M, Barnabei, A, Pompeo, V, Sentinelli, S, Baldelli, R, Corsello, Salvatore Maria, Torino, F., and Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274)

Abstract

The involvement of the testis by metastatic medullary thyroid carcinoma has never been described before. We describe the first case of metastatic medullary thyroid carcinoma affecting testis and inguinal lymph nodes.

Published
2014

42. Long-term treatment of somatostatin analog-refractory growth hormone-secreting pituitary tumors with pegvisomant alone or combined with long-acting somatostatin analogs: a retrospective analysis of clinical practice and outcomes

Author

Bianchi, Antonio, Valentini, F, Iuorio, R, Poggi, M, Baldelli, R, Passeri, M, Giampietro, Antonella, Tartaglione, Linda, Chiloiro, Sabrina, Appetecchia, M, Gargiulo, P, Fabbri, A, Toscano, V, Pontecorvi, Alfredo, De Marinis Grasso, Laura, Chiloiro, Sabrina (ORCID:0000-0001-9241-2392), Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865), De Marinis, Laura (ORCID:0000-0001-9916-0669), Bianchi, Antonio, Valentini, F, Iuorio, R, Poggi, M, Baldelli, R, Passeri, M, Giampietro, Antonella, Tartaglione, Linda, Chiloiro, Sabrina, Appetecchia, M, Gargiulo, P, Fabbri, A, Toscano, V, Pontecorvi, Alfredo, De Marinis Grasso, Laura, Chiloiro, Sabrina (ORCID:0000-0001-9241-2392), Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865), and De Marinis, Laura (ORCID:0000-0001-9916-0669)

Abstract

Pegvisomant (PEGV) is widely used, alone or with somatostatin analogs (SSA), for GH-secreting pituitary tumors poorly controlled by SSAs alone. No information is available on specific indications for or relative efficacies of PEGV+SSA versus PEGV monotherapy. Aim of our study was to characterize real-life clinical use of PEGV vs. PEGV+SSA for SSA-resistant acromegaly (patient selection, long-term outcomes, adverse event rates, doses required to achieve control).

Published
2013

43. Thyroid dysfunction as an unintended side effect of anticancer drugs

Author

Torino, F, Barnabei, A, Paragliola, Rosa Maria, Baldelli, R, Appetecchia, M, Corsello, Salvatore Maria, Paragliola, Rosa Maria (ORCID:0000-0002-5070-7771), Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274), Torino, F, Barnabei, A, Paragliola, Rosa Maria, Baldelli, R, Appetecchia, M, Corsello, Salvatore Maria, Paragliola, Rosa Maria (ORCID:0000-0002-5070-7771), and Corsello, Salvatore Maria (ORCID:0000-0002-4544-7274)

Abstract

Several of the currently used anticancer drugs may variably affect thyroid function, with impairment ranging from modified total but not free concentration of thyroid hormones to overt thyroid disease.

Published
2013

46. Microalbuminuria in insulin sensitivity in patients with growth hormone-secreting pituitary tumor.

Author

Baldelli, R, De Marinis, Laura, Bianchi, Antonio, Pivonello, R, Gasco, V, Auriemma, R, Pasimeni, G, Cimino, V, Appetecchia, M, Maccario, M, Lombardi, G, Pontecorvi, Alfredo, Colao, A, Grottoli, S., De Marinis, Laura (ORCID:0000-0001-9916-0669), Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865), Baldelli, R, De Marinis, Laura, Bianchi, Antonio, Pivonello, R, Gasco, V, Auriemma, R, Pasimeni, G, Cimino, V, Appetecchia, M, Maccario, M, Lombardi, G, Pontecorvi, Alfredo, Colao, A, Grottoli, S., De Marinis, Laura (ORCID:0000-0001-9916-0669), and Pontecorvi, Alfredo (ORCID:0000-0003-0570-6865)

Published
2008

47. Predictors of morbidity and mortality in acromegaly: an Italian survey

Author

Arosio, M, primary, Reimondo, G, additional, Malchiodi, E, additional, Berchialla, P, additional, Borraccino, A, additional, De Marinis, L, additional, Pivonello, R, additional, Grottoli, S, additional, Losa, M, additional, Cannavò, S, additional, Minuto, F, additional, Montini, M, additional, Bondanelli, M, additional, De Menis, E, additional, Martini, C, additional, Angeletti, G, additional, Velardo, A, additional, Peri, A, additional, Faustini-Fustini, M, additional, Tita, P, additional, Pigliaru, F, additional, Borretta, G, additional, Scaroni, C, additional, Bazzoni, N, additional, Bianchi, A, additional, Appetecchia, M, additional, Cavagnini, F, additional, Lombardi, G, additional, Ghigo, E, additional, Beck-Peccoz, P, additional, Colao, A, additional, Terzolo, M, additional, and _, _, additional

Published
2012
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48. Measuring calcitonin in washout of the needle in patients undergoing fine needle aspiration with suspicious medullary thyroid cancer

Author

Trimboli, P., primary, Rossi, F., additional, Baldelli, R., additional, Laurenti, O., additional, Nigri, G., additional, Ventura, C., additional, Appetecchia, M., additional, Attanasio, D., additional, Romanelli, F., additional, Guidobaldi, L., additional, Guarino, M., additional, Crescenzi, A., additional, and Valabrega, S., additional

Published
2011
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