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1. Definition of the Post-COVID syndrome using a symptom-based Post-COVID score in a prospective, multi-center, cross-sectoral cohort of the German National Pandemic Cohort Network (NAPKON)

Author

Appel, Katharina S., Nürnberger, Carolin, Bahmer, Thomas, Förster, Christian, Polidori, Maria Cristina, Kohls, Mirjam, Kraus, Tanja, Hettich-Damm, Nora, Petersen, Julia, Blaschke, Sabine, Bröhl, Isabel, Butzmann, Jana, Dashti, Hiwa, Deckert, Jürgen, Dreher, Michael, Fiedler, Karin, Finke, Carsten, Geisler, Ramsia, Hanses, Frank, Hopff, Sina M., Jensen, Björn-Erik O., Konik, Margarethe, Lehnert, Kristin, de Miranda, Susana M. Nunes, Mitrov, Lazar, Miljukov, Olga, Reese, Jens-Peter, Rohde, Gernot, Scherer, Margarete, Tausche, Kristin, Tebbe, Johannes J., Vehreschild, Jörg Janne, Voit, Florian, Wagner, Patricia, Weigl, Martin, and Lemhöfer, Christina

Published
2024
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2. A precise performance-based reimbursement model for the multi-centre NAPKON cohorts – development and evaluation

Author

Appel, Katharina S., Lee, Chin Huang, Nunes de Miranda, Susana M., Maier, Daniel, Reese, Jens-Peter, Anton, Gabriele, Bahmer, Thomas, Ballhausen, Sabrina, Balzuweit, Beate, Bellinghausen, Carla, Blumentritt, Arne, Brechtel, Markus, Chaplinskaya-Sobol, Irina, Erber, Johanna, Fiedler, Karin, Geisler, Ramsia, Heyder, Ralf, Illig, Thomas, Kohls, Mirjam, Kollek, Jenny, Krist, Lilian, Lorbeer, Roberto, Miljukov, Olga, Mitrov, Lazar, Nürnberger, Carolin, Pape, Christian, Pley, Christina, Schäfer, Christian, Schaller, Jens, Schattschneider, Mario, Scherer, Margarete, Schulze, Nick, Stahl, Dana, Stubbe, Hans Christian, Tamminga, Thalea, Tebbe, Johannes Josef, Vehreschild, Maria J. G. T., Wiedmann, Silke, and Vehreschild, Jörg Janne

Published
2024
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3. Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV-2 variants delta and omicron—results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP)

Author

Hopff, Sina M., Appel, Katharina S., Miljukov, Olga, Schneider, Johannes, Addo, Marylyn M., Bals, Robert, Bercker, Sven, Blaschke, Sabine, Bröhl, Isabel, Büchner, Nikolaus, Dashti, Hiwa, Erber, Johanna, Friedrichs, Anette, Geisler, Ramsia, Göpel, Siri, Hagen, Marina, Hanses, Frank, Jensen, Björn-Erik Ole, Keul, Maria, Krawczyk, Adalbert, Lorenz-Depiereux, Bettina, Meybohm, Patrick, Milovanovic, Milena, Mitrov, Lazar, Nürnberger, Carolin, Obst, Wilfried, Römmele, Christoph, Schäfer, Christian, Scheer, Christian, Scherer, Margarete, Schmidt, Julia, Seibel, Kristina, Sikdar, Shimita, Tebbe, Johannes Josef, Tepasse, Phil-Robin, Thelen, Philipp, Vehreschild, Maria J. G. T., Weismantel, Christina, and Vehreschild, J. Janne

Published
2024
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4. Use and effectiveness of remdesivir for the treatment of patients with covid-19 using data from the Lean European Open Survey on SARS-CoV-2 infected patients (LEOSS): a multicentre cohort study

Author

Pilgram, Lisa, Appel, Katharina S., Ruethrich, Maria M., Koll, Carolin E. M., Vehreschild, Maria J. G. T., de Miranda, Susana M. Nunes, Hower, Martin, Hellwig, Kerstin, Hanses, Frank, Wille, Kai, Haselberger, Martina, Spinner, Christoph D., Vom Dahl, Juergen, Hertenstein, Bernd, Westhoff, Timm, Vehreschild, J. Janne, Jensen, Björn-Erik Ole, and Stecher, Melanie

Published
2023
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5. Depression and fatigue six months post-COVID-19 disease are associated with overlapping symptom constellations: A prospective, multi-center, population-based cohort study

Author

Weiß, Martin, Gutzeit, Julian, Appel, Katharina S., Bahmer, Thomas, Beutel, Manfred, Deckert, Jürgen, Fricke, Julia, Hanß, Sabine, Hettich-Damm, Nora, Heuschmann, Peter U., Horn, Anna, Jauch-Chara, Kamila, Kohls, Mirjam, Krist, Lilian, Lorenz-Depiereux, Bettina, Otte, Christian, Pape, Daniel, Reese, Jens-Peter, Schreiber, Stefan, Störk, Stefan, Vehreschild, Jörg Janne, and Hein, Grit

Published
2024
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6. The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics

Author

Schons, Maximilian, Pilgram, Lisa, Reese, Jens-Peter, Stecher, Melanie, Anton, Gabriele, Appel, Katharina S., Bahmer, Thomas, Bartschke, Alexander, Bellinghausen, Carla, Bernemann, Inga, Brechtel, Markus, Brinkmann, Folke, Brünn, Clara, Dhillon, Christine, Fiessler, Cornelia, Geisler, Ramsia, Hamelmann, Eckard, Hansch, Stefan, Hanses, Frank, Hanß, Sabine, Herold, Susanne, Heyder, Ralf, Hofmann, Anna-Lena, Hopff, Sina Marie, Horn, Anna, Jakob, Carolin, Jiru-Hillmann, Steffi, Keil, Thomas, Khodamoradi, Yascha, Kohls, Mirjam, Kraus, Monika, Krefting, Dagmar, Kunze, Sonja, Kurth, Florian, Lieb, Wolfgang, Lippert, Lena Johanna, Lorbeer, Roberto, Lorenz-Depiereux, Bettina, Maetzler, Corina, Miljukov, Olga, Nauck, Matthias, Pape, Daniel, Püntmann, Valentina, Reinke, Lennart, Römmele, Christoph, Rudolph, Stefanie, Sass, Julian, Schäfer, Christian, Schaller, Jens, Schattschneider, Mario, Scheer, Christian, Scherer, Margarete, Schmidt, Sein, Schmidt, Julia, Seibel, Kristina, Stahl, Dana, Steinbeis, Fridolin, Störk, Stefan, Tauchert, Maike, Tebbe, Johannes Josef, Thibeault, Charlotte, Toepfner, Nicole, Ungethüm, Kathrin, Vadasz, Istvan, Valentin, Heike, Wiedmann, Silke, Zoller, Thomas, Nagel, Eike, Krawczak, Michael, von Kalle, Christof, Illig, Thomas, Schreiber, Stefan, Witzenrath, Martin, Heuschmann, Peter, and Vehreschild, Jörg Janne

Published
2022
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7. Comparison of post-COVID-19 symptoms in patients infected with the SARS-CoV- 2 variants delta and omicron - results of the Cross-Sectoral Platform of the German National Pandemic Cohort Network (NAPKON-SUEP)

Author

Hopff, Sina M., primary, Appel, Katharina S., additional, Miljukov, Olga, additional, Schneider, Johannes, additional, Addo, Marylyn M., additional, Bals, Robert, additional, Bercker, Sven, additional, Blaschke, Sabine, additional, Bröhl, Isabel, additional, Büchner, Nikolaus, additional, Dashti, Hiwa, additional, Erber, Johanna, additional, Friedrichs, Anette, additional, Geisler, Ramsia, additional, Göpel, Siri, additional, Hagen, Marina, additional, Hanses, Frank, additional, Jensen, Björn-Erik Ole, additional, Keul, Maria, additional, Krawczyk, Adalbert, additional, Lorenz-Depiereux, Bettina, additional, Meybohm, Patrick, additional, Milovanovic, Milena, additional, Mitrov, Lazar, additional, Nürnberger, Carolin, additional, Obst, Wilfried, additional, Römmele, Christoph, additional, Schäfer, Christian, additional, Scheer, Christian, additional, Scherer, Margarete, additional, Schmidt, Julia, additional, Seibel, Kristina, additional, Sikdar, Shimita, additional, Tebbe, Johannes Josef, additional, Tepasse, Phil-Robin, additional, Thelen, Philipp, additional, Vehreschild, Maria J.G.T., additional, Weismantel, Christina, additional, and Vehreschild, J. Janne, additional

Published
2024
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8. A Systematic Review of Predictor Composition, Outcomes, Risk of Bias, and Validation of COVID-19 Prognostic Scores.

Author

Appel, Katharina S, Geisler, Ramsia, Maier, Daniel, Miljukov, Olga, Hopff, Sina M, and Vehreschild, J Janne

Subjects
*RISK assessment, *PREDICTION models, *RESEARCH funding, *EVALUATION of medical care, *DESCRIPTIVE statistics, *SEVERITY of illness index, *SYSTEMATIC reviews, *MEDLINE, *SOCIODEMOGRAPHIC factors, *COVID-19
Abstract

Background Numerous prognostic scores have been published to support risk stratification for patients with coronavirus disease 2019 (COVID-19). Methods We performed a systematic review to identify the scores for confirmed or clinically assumed COVID-19 cases. An in-depth assessment and risk of bias (ROB) analysis (Prediction model Risk Of Bias ASsessment Tool [PROBAST]) was conducted for scores fulfilling predefined criteria ([I] area under the curve [AUC)] ≥ 0.75; [II] a separate validation cohort present; [III] training data from a multicenter setting [≥2 centers]; [IV] point-scale scoring system). Results Out of 1522 studies extracted from MEDLINE/Web of Science (20/02/2023), we identified 242 scores for COVID-19 outcome prognosis (mortality 109, severity 116, hospitalization 14, long-term sequelae 3). Most scores were developed using retrospective (75.2%) or single-center (57.1%) cohorts. Predictor analysis revealed the primary use of laboratory data and sociodemographic information in mortality and severity scores. Forty-nine scores were included in the in-depth analysis. The results indicated heterogeneous quality and predictor selection, with only five scores featuring low ROB. Among those, based on the number and heterogeneity of validation studies, only the 4C Mortality Score can be recommended for clinical application so far. Conclusions The application and translation of most existing COVID scores appear unreliable. Guided development and predictor selection would have improved the generalizability of the scores and may enhance pandemic preparedness in the future. [ABSTRACT FROM AUTHOR]

Published
2024
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9. 1886. External Validation of the 4C Mortality Score and the qSOFA for Different Variants of Concerns of SARS-CoV-2 Using Data of the NAPKON Cross-Sectoral Cohort Platform (SUEP)

Author

Appel, Katharina S, primary, Maier, Daniel, additional, Hopff, Sina M, additional, Mitrov, Lazar, additional, Stecher, Melanie, additional, Scherer, Margarete, additional, Geisler, Ramsia, additional, Hagen, Marina, additional, Haas, Kirsten, additional, Reese, Jens-Peter, additional, Jiru-Hillmann, Steffi, additional, Miljukov, Olga, additional, Jakob, Carolin E M, additional, Nunes de Miranda, Susana M, additional, Meybohm, Patrick, additional, Hanß, Sabine, additional, Erber, Johanna, additional, Winter, Christof, additional, Tebbe, Johannes J, additional, Stellbrink, Christoph, additional, Khodamoradi, Yascha, additional, Schmidt, Julia, additional, Hanses, Frank, additional, Scheer, Christian, additional, Blaschke, Sabine, additional, Göpel, Siri, additional, Kluge, Stefan, additional, Witzke, Oliver, additional, Römmele, Christoph, additional, Krawczyk, Marcin, additional, Teufel, Andreas, additional, Schmid, Jonas, additional, Pape, Daniel, additional, Schütte, Christian, additional, Tausche, Kristin, additional, Milovanovic, Milena, additional, Krug, Natalie, additional, Tepasse, Phil-Robin, additional, Verket, Marlo, additional, Hamprecht, Axel, additional, Tasci, Selcuk, additional, Hower, Martin, additional, Jensen, Björn-Erik O, additional, Sprinzl, Martin F, additional, Zimmermann, Tim, additional, and Vehreschild, Jörg J, additional

Published
2022
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11. Post COVID - Just a matter of definition?

Author

Lemhoefer, Christina, Appel, Katharina S., Haeuser, Winfried, Hettich, Nora, Kohls, Mirjam, Polidori, Maria Cristina, Lemhoefer, Christina, Appel, Katharina S., Haeuser, Winfried, Hettich, Nora, Kohls, Mirjam, and Polidori, Maria Cristina

Abstract

The prevalence of post-COVID syndrome (PCS) has not yet been conclusively clarified. The existing definitions primarily reflect temporal aspects, but disregard functional deficits as well as the objectification of symptoms. This leads to diagnostic as well as therapeutic ambiguities. Pubmed was searched for systematic reviews dealing with the impact of SARS-CoV-2 infection. The underlying definitions as well as temporal inclusion criteria were extracted. 16 systematic reviews were included, 11 of which included a definition of PCS. In 58 % of the individual studies analyzed, patients with symptomatology > 12 weeks and thus according to the definition of PCS were included. Conclusion: Further clarification of the definition of PCS is necessary to facilitate diagnosis and multimodal treatment and to use the scarce therapeutic resources accordingly.

Published
2022

12. [Post COVID - Just a matter of definition?]

Author

Lemhöfer C, Appel KS, Häuser W, Hettich N, Kohls M, and Polidori MC

Subjects
Humans, SARS-CoV-2, Systematic Reviews as Topic, Prevalence, COVID-19
Abstract

The prevalence of post-COVID syndrome (PCS) has not yet been conclusively clarified. The existing definitions primarily reflect temporal aspects, but disregard functional deficits as well as the objectification of symptoms. This leads to diagnostic as well as therapeutic ambiguities. Pubmed was searched for systematic reviews dealing with the impact of SARS-CoV-2 infection. The underlying definitions as well as temporal inclusion criteria were extracted. 16 systematic reviews were included, 11 of which included a definition of PCS. In 58 % of the individual studies analyzed, patients with symptomatology > 12 weeks and thus according to the definition of PCS were included. CONCLUSION:: Further clarification of the definition of PCS is necessary to facilitate diagnosis and multimodal treatment and to use the scarce therapeutic resources accordingly., Competing Interests: Alle Autoren arbeiten in nicht leitender Funktion im Netzwerk Universitätsmedizin;CP, NH, WH und CL als Sprecher*innen ihrer entsprechenden Fachgruppe im Fachbeirat;MK und KA im Nukleus-Interaktionskern., (Thieme. All rights reserved.)

Published
2022
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