Search

Aim: To evaluate drugs interactions with oral anticoagulants and their clinical relevance, in patients from two emergency departments in hospital., Material and Methods: Retrospective study, during one year, on patients (between 18 and 85 year old) with haemostatic disturbances admitted at two emergency departments in ,,Sf. Spiridon" Hospital, Iaşi and in Piatra Neamţ Public Hospital, consisted in medical records analysis: the diagnostic, therapy recommended. Data were scored and statistically analyzed by t test (Windows Excel). The experimental protocol was in agreement with recommendations of the "Gr. T. Popa" University Committee for Research and Ethical Issues., Results and Conclusions: Analysis and statistical processing of data shows that during the period of the study, 69 patients, which received oral anticoagulant therapy associated with different other medication belonged to the 60 and 80 years age group. The findings suggests the pathology is represented especially by atrial fibrillation and cerebral ischemic diseases. The correlation between the therapy consisting in OAC and amiodaronum or statines drugs association and International Normalized Ratio (INR), revealed a high level of anticoagulation and an increase of hemorragic complications.

Aims: to assess the profile and the characteristic of oncological patients, establishing management in patients with neoplasia presented in the emergency department (ED), the analysis of short-term movements in patients with neoplasia whilst in the ED., Material and Methods: we performed a retrospective study on nonrandomized consecutive cases. The lot analysis included 1315 oncological patients admitted in the Emergency Department of the Clinical Emergency Hospital "St. Spiridon" Iaşi, in the period June 1st, 2009 - May 31st, 2010. 23.12% of the patients had high suspicion of neoplasia at the first visit to the ED., Results: 67.07% of patients were in metastatic stage disease located as follows: liver metastasis 37.59%, lung metastasis 18.36%, lymph node metastasis 13, 29%. After processing the data there were found statistically significant correlations between the age of patients and the documented/suspected diagnosis of neoplasia (p = 0.01) in the sense that a neoplasia diagnosis in emergency was more frequent in people of young age. It should be mentioned that other studies rarely mention first diagnosis of neoplasia in emergency department with presence of complications., Conclusion: 1315 oncological patients presented in ED, almost a quarter of which presented high suspicion of neoplasia (still without histopathological confirmation) when in ED (23.12%). Most of them were aged male patients (over 65 years old), with tumors of the digestive system. A significant proportion (almost 60%) of these patients ended up in emergency due to complications and the therapy intended life support and pain management. Some of these patients were directed to further exploring and emergency outpatient therapy while 75% of patients were hospitalized after stabilization. Although we expected that the frequency of complications to be higher in patients previously diagnosed with cancer, data analysis showed no statistically significant differences (p = NS) between the rate of complications in patients previously diagnosed with neoplasia and those with high-suspicion neoplasia first diagnosed in the ED.

Unlabelled: Oral anticoagulants (OAC) are commonly used as a life-long therapy in the prevention of systemic embolism in patients with atrial fibrillation, valvular heart disease, prosthetic heart valves, and in the primary and secondary prevention of venous thromboembolism, in patients with acute myocardial infarction and angina pectoris. Drugs, herbs, and multivitamin supplements can alter the absorption, pharmacokinetics or pharmacodynamics of OAC., Aim: To investigate the possible interactions between oral anticoagulants and different drugs administered in patients in emergency department., Methods: This 1-year exploratory investigation on 93 patients on OAC (aged 30 - 85 years), admitted at two emergency departments of the Iasi "Sf. Spiridon" Hospital and Piatra Neamţ Hospital, consisted in their medical records analysis: diagnosis, recommended treatement. Data were scored and statistically analyzed by t-test (Windows Excel). The experimental protocol was in agreement with the recommendations of the Gr.T. Popa University Committee for Research and Ethical Issues., Results and Conclusions: Analysis and statistical processing of data shows that during the study period 56 patients which received oral anticoagulant therapy associated with different other medication belonged to the 60 and 80 years age group. This finding suggests that the pathology is represented especially by atrial fibrillation and myocardial infarction. The correlation between the therapy consisting in OAC and sartan or nonsteroidal anti-inflammatory drugs and International Normalized Ratio (INR), revealed a high level of anticoagulation and an increase in hemorragic complications.