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Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Revista Foco (Interdisciplinary Studies Journal) is the property of Revista Foco and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

OSAS (Obstructive Sleep Apnea Syndrome) is considered a respiratory ailment, characterized by repeated pauses, being a frequent condition in the population. Its expression and severity result in interactions between anatomical and physiological changes, and any factors that reduce the caliber of the airways can result in this manifestation, with high rates of comorbidities and mortality in the population. Highlighting the main signs and symptoms, loud and disturbing snoring, excessive sleepiness at night, nonrestorative sleep and behavior and mood disorders can be highlighted. This work aims to identify the incidence of OSAS in the population of patients attending the Dentistry course at Faculdade Evangélica de Goianésia, considering a relevant sample that present related comorbidities as described in recent literature. [ABSTRACT FROM AUTHOR]

RESUMO Objetivo: Investigamos a frequência dos testes de apneia e o uso de exames complementares para o diagnóstico de morte cerebral em nosso hospital, assim como as razões para a não realização do teste de apneia e para utilização de exames complementares. Métodos: Neste estudo retrospectivo, examinaram-se os arquivos de pacientes com diagnóstico de morte cerebral entre 2012 e 2018. O exame preferido foi determinado quando um exame complementar foi realizado para o diagnóstico de morte cerebral. Analisaram-se a taxa e a frequência de uso desses exames. Resultados: Durante o diagnóstico de morte cerebral, o teste de apneia foi realizado em 104 (61,5%) pacientes, e não foi ou não pôde ser realizado em 65 (38,5%) deles. Realizaram-se exames complementares em 139 (82,8%) pacientes. O exame complementar mais comumente utilizado foi a angiografia por tomografia computadorizada (79 pacientes, 46,7%). Foi recebida aprovação para doação de órgãos nas reuniões com familiares após o diagnóstico de morte cerebral para 55 (32,5%) dos 169 pacientes. Conclusão: Nos anos mais recentes, identificamos aumento na taxa de testes de apneia incompletos e, concordantemente, elevação no uso de exames complementares. Os exames complementares devem ser utilizados nos pacientes quando há dificuldade para chegar à decisão do diagnóstico de morte cerebral, mas não se deve esquecer que não existe um consenso mundial a respeito do uso de exames complementares.

A Jornada de Fonoaudiologia da FMRP-USP ocorre a cada dois anos, no primeiro semestre. Esse evento científico conta, na sua organização, com a participação de discentes e docentes do curso de Fonoaudiologia da FMRP-USP. Iniciada em 2007, o objetivo do evento é enriquecer o saber acadêmico, aproximando os estudantes da comunidade científica nacional, além de ofertar aos fonoaudiólogos de Ribeirão Preto e região mais uma oportunidade de atualização de conhecimentos. A VIII Jornada de Fonoaudiologia da FMRP-USP ocorrida entre os dias 26 e 28 de maio de 2021 aconteceu, pela primeira vez, de forma online e no período noturno. Em função do contexto da Pandemia da Covid-19, e atendendo às medidas de prevenção recomendadas pelo Ministério da Saúde e pelo órgão gestor local de saúde, a estrutura da jornada teve de ser adaptada para evitar aglomerações. Foram organizadas duas noites para o desenvolvimento de palestras e uma noite para a apresentação de trabalhos científicos. As palestras abordaram temas bastante relevantes e inovadores para a área de Fonoaudiologia, como: teleatendimento, ética nas redes sociais, seletividade alimentar, transtorno do espectro autista (TEA), Fonoaudiologia no ronco e na apneia do sono, comunicação nas incongruências de gênero e promoção de saúde auditiva nas escolas. Pela primeira vez, toda a verba arrecadada com o evento foi revertida em produtos de higiene e de limpeza para instituições de cuidado a idosos e crianças, ambos em situações de vulnerabilidade. Outra novidade foi a parceria com as entidades estudantis de outras instituições de ensino superior que auxiliaram na divulgação do evento e na formação da Comissão Avaliadora para julgar a qualidade dos trabalhos científicos.

Extracorporeal membrane oxygenation is used as extracirculatory support for the care of patients with severe and reversible cardiac and/or respiratory failure. Neurological complications may be related to the procedure. Given the unfavorable neurological evolution and the need to perform a brain death protocol, the performance of an apnea test in this context remains a challenge. We report the use of an apnea test for the diagnosis of brain death postcardiac surgery in a patient receiving venoarterial extracorporeal membrane oxygenation. [ABSTRACT FROM AUTHOR]

Objective: We investigated the frequency of apnea tests, and the use of ancillary tests in the diagnosis of brain death in our hospital, as well as the reasons for not being able to perform apnea testing and the reasons for using ancillary tests. Methods: In this retrospective study, the files of patients diagnosed with brain death between 2012 - 2018 were examined. The preferred test was determined if an ancillary test was performed in the diagnosis of brain death. The rate and frequency of use of these tests were analyzed. Results: During the diagnosis of brain death, an apnea test was performed on 104 (61.5%) patients and was not or could not be performed on 65 (38.5%) patients. Ancillary tests were performed on 139 (82.8%) of the patients. The most common ancillary test was computed tomography angiography (79 patients, 46.7%). Approval for organ donation was received in the meetings with the family following the diagnosis of brain death for 55 (32.5%) of the 169 patients. Conclusion: We found an increase in the rate of incomplete apnea tests and concordantly, an increase in the use of ancillary tests in recent years. Ancillary tests should be performed on patients when there is difficulty in reaching a decision of brain death, but it should not be forgotten that there is no worldwide consensus on the use of ancillary tests. [ABSTRACT FROM AUTHOR]

The apnea test, which involves disconnection from the mechanical ventilator, presents risks during the determination of brain death, especially in hypoxemic patients. We describe the performance of the apnea test without disconnection from the mechanical ventilator in two patients. The first case involved an 8-year-old boy admitted with severe hypoxemia due to pneumonia. He presented with cardiorespiratory arrest, followed by unresponsive coma due to hypoxic-ischemic encephalopathy. Two clinical exams revealed the absence of brainstem reflexes, and transcranial Doppler ultrasound revealed brain circulatory arrest. Three attempts were made to perform the apnea test, which were interrupted by hypoxemia; therefore, the apnea test was performed without disconnection from the mechanical ventilator, adjusting the continuous airway pressure to 10cmH2O and the inspired fraction of oxygen to 100%. The oxygen saturation was maintained at 100% for 10 minutes. Posttest blood gas analysis results were as follows: pH, 6.90; partial pressure of oxygen, 284.0mmHg; partial pressure of carbon dioxide, 94.0mmHg; and oxygen saturation, 100%. The second case involved a 43-year-old woman admitted with subarachnoid hemorrhage (Hunt-Hess V and Fisher IV). Two clinical exams revealed unresponsive coma and absence of all brainstem reflexes. Brain scintigraphy showed no radioisotope uptake into the brain parenchyma. The first attempt at the apnea test was stopped after 5 minutes due to hypothermia (34.9°C). After rewarming, the apnea test was repeated without disconnection from the mechanical ventilator, showing maintenance of the functional residual volume with electrical bioimpedance. Posttest blood gas analysis results were as follows: pH, 7.01; partial pressure of oxygen, 232.0mmHg; partial pressure of carbon dioxide, 66.9mmHg; and oxygen saturation, 99.0%. The apnea test without disconnection from the mechanical ventilator allowed the preservation of oxygenation in both cases. The use of continuous airway pressure during the apnea test seems to be a safe alternative in order to maintain alveolar recruitment and oxygenation during brain death determination. [ABSTRACT FROM AUTHOR]

Atualmente a SAOS é reconhecida como um preditor independente para a obesidade, e esta, por sua vez, caracteriza-se como o principal fator de risco para a SAOS. Com isso, o presente artigo visa revisar a literatura existente sobre a relação entre SAOS e obesidade, considerando os aspectos endócrinos e metabólicos desta relação, bem como discutir o papel da perda de peso no tratamento desta síndrome. Diversos estudos têm demonstrado que a SAOS está diretamente associada às alterações endócrinas, como os níveis de leptina e grelina, hormônios relacionados a fome e saciedade, bem como pode contribuir para o aumento da resistência à insulina e do cortisol, elevando o risco de doenças crônicas, como as cardiovasculares. Considerando que a SAOS é fator de risco independente para hipertensão e doenças cardiovasculares, além de ser fortemente associada com a obesidade e a resistência à insulina, diversos tratamentos têm sido propostos atualmente, incluindo cirurgias, aparelhos intra orais, uso de CPAP, bem como mudanças de estilo de vida, as quais focam na inclusão de exercícios físicos e diminuição da ingestão calórica, o que promove a redução de medidas antropométricas e melhora no IAH e parâmetros respiratórios. Conclui-se que a SAOS e a obesidade desencadeiam alterações endócrinas e metabólicas, as quais podem atuar negativamente na saúde do indivíduo. Desta forma, pode-se afirmar que a redução da massa corporal é clinicamente importante para pacientes obesos com SAOS, devendo ser uma medida de importante atenção no tratamento desta doença. ABSTRACT Relationship between obstructive sleep apnea and obesity: a review of endocrine, metabolic and nutritional aspects Currently OSAS is recognized as an independent predictor for obesity, and this, in turn, is characterized as the main risk factor for OSAS. This article aims to review the existing literature on the relationship between OSA and obesity, whereas endocrine and metabolic aspects of this relationship and to discuss the role of weight loss in the treatment of this syndrome. Several studies have shown that OSA is directly associated with endocrine disorders such as leptin levels and ghrelin, hormones related to hunger and satiety, and can contribute to increased insulin resistance and cortisol, increasing the risk of chronic diseases such as cardiovascular. Whereas OSAS is an independent risk factor for hypertension and cardiovascular disease, as well as being strongly associated with obesity and insulin resistance, various treatments have been currently proposed, including surgery, oral appliances, CPAP use, as well as changes in lifestyle, which focus on inclusion of exercise and decreased calorie intake, which promotes the reduction of anthropometric measurements and improvement in AHI and respiratory parameters. It is concluded that OSA and obesity trigger endocrine and metabolic disorders, which can negatively affect the health of the individual. Thus, it can be said that the reduction of body mass is clinically important for obese patients with OSAS and should be a measure of important attention in the treatment of this disease.

Introduction: Obstructive sleep apnea and/or hypopnea syndrome (OSAHS) is characterized by repeated obstruction of the airway or reduction of breathing during sleep. This syndrome is caused by pharyngeal collapse against increased respiratory effort during sleep. SAHOS leads to deterioration of sleep quality associated with clinical complaints of excessive daytime sleepiness and unfavorable effects on the cardiovascular system. Orofacial features such as mandibular retrognathism and/or associated maxillary retrognathism, Class II malocclusion, with or without open bite and reduction of the oropharyngeal airway characterize this syndrome. Objective: It is reported an orthosurgical treatment of a 31 years old male patient, with OSAHS characteristics, Class II malocclusion, mandibular deficiency, posterior crossbite and anterior open bite, lower anterior facial height decrease, deepening of the labial sulcus, little exposure of the lower lip and unbalanced face. Report and Results: Non-invasive treatments for OSAHS pass through positive continuous nasal pressure devices in the airways or intra-oral appliances in order to maintain the mandible in an anterior position during sleep. In the invasive treatments protocol, mandibular advancement surgery prevents rotation in the anti-clockwise direction of the maxillomandibular complex with an increase in the oropharyngeal space of the middle and lower airways. In cases with great skeletal dentofacial impact associated with the degree of obstruction of the airway will be necessary an ortho-surgical decompensatory treatment, to allow a respiratory and aesthetic restoration of the face. Conclusion: The decompensatory treatment with bimaxillary surgical advancement corrected the malocclusion, increasing the air space contemplating the respiratory, functional and aesthetic expectation. [ABSTRACT FROM AUTHOR]

Objective : To determine whether there are significant differences between rapid-eye-movement (REM)-related obstructive sleep apnea (OSA) and non-REM (NREM)-related OSA, in terms of the demographic, anthropometric, and polysomnographic characteristics of the subjects. Methods : This was a retrospective study of 110 patients (75 males) with either REM-related OSA (n = 58) or NREM-related OSA (n = 52). To define REM-related and NREM-related OSA, we used a previously established criterion, based on the apnea-hypopnea index (AHI): AHI-REM/AHI-NREM ratio > 2 and ≤ 2, respectively. Results : The mean age of the patients with REM-related OSA was 49.5 ± 11.9 years, whereas that of the patients with NREM-related OSA was 49.2 ± 12.6 years. The overall mean AHI (all sleep stages combined) was significantly higher in the NREM-related OSA group than in the REM-related OSA group (38.6 ± 28.2 vs. 14.8 ± 9.2; p < 0.05). The mean AHI in the supine position (s-AHI) was also significantly higher in the NREM-related OSA group than in the REM-related OSA group (49.0 ± 34.3 vs. 18.8 ± 14.9; p < 0.0001). In the NREM-related OSA group, the s-AHI was higher among the men. In both groups, oxygen desaturation was more severe among the women. We found that REM-related OSA was more common among the patients with mild-to-moderate OSA, whereas NREM-related OSA was more common among those with severe OSA. Conclusions : We found that the severity of NREM-related OSA was associated mainly with s-AHI. Our findings suggest that the s-AHI has a more significant effect on the severity of OSA than does the AHI-REM. When interpreting OSA severity and choosing among treatment modalities, physicians should take into consideration the sleep stage and the sleep posture.

Objetivo: avaliar parâmetros polissonográficos de pacientes com indicação para uso de AOPMs.Métodos: estudaram-se, retrospectivamente, os dados de prontuários com base em itens que compunham a polissonografia de 124 pacientes com idade entre 25 e 77 anos, que não estavam fazendo nenhum tratamento para distúrbios do sono. O estudo foi aprovado pelo Comitê de Ética em Pesquisa da instituição de origem (CAE n o 0378.0.133.000-10).Resultados: 46,8% dos pesquisados tinham diagnóstico de apnéia leve, 91,8% roncavam e tinha uma eficiência do sono insatisfatória. Dos pacientes que roncavam, a quase totalidade apresentava SAHOS. A menor saturação de oxigênio durante o exame variou entre 60% e 97%, com mais de quatro quintos da amostra com índices abaixo de 90%.Conclusão: não houve relação significante entre os índices de apnéia e os níveis de saturação de oxi-hemoglobina. A eficiência do sono esteve diretamente relacionada à severidade da SAHOS, com evidências estatísticas; a oximetria pode ser um valioso instrumento para o diagnóstico da SAHOS, mas não pode ser única fonte para referenciar a gravidade da síndrome; o sono REM foi insatisfatório na maioria dos pesquisados, e este esteve significantemente relacionado à eficiência do sono.

ABSTRACTBACKGROUND AND OBJECTIVES: the "shortness of breath" or "breathing interruption" crisis can be considered a cause of hypoxia in childhood. It is characterized by the presence of a triggering factor followed by weeping and apnea in expiration accompanied by cyanosis or pallor. The sequence of events may include bradycardia, loss of consciousness, abnormal postural tone and even asystole. A review of the literature revealed only two reports of postoperative apnea caused by "shortness of breath".CASE REPORT: this article describes the case of a child with a history of "shortness of breath" undiagnosed before the adenotonsillectomy, but that represented the cause of episodes of hypoxemia and bradycardia in the postoperative period.CONCLUSIONS: the "shortness of breath" crisis should be considered as a possible cause of perioperative hypoxia in children, especially when there is a history suggestive of this problem. As some events may be accompanied by bradycardia, loss of consciousness, abnormal postural tone and even asystole, observation in a hospital setting should be considered.

Currently OSAS is recognized as an independent predictor for obesity, and this, in turn, is characterized as the main risk factor for OSAS. This article aims to review the existing literature on the relationship between OSA and obesity, whereas endocrine and metabolic aspects of this relationship and to discuss the role of weight loss in the treatment of this syndrome. Several studies have shown that OSA is directly associated with endocrine disorders such as leptin levels and ghrelin, hormones related to hunger and satiety, and can contribute to increased insulin resistance and cortisol, increasing the risk of chronic diseases such as cardiovascular. Whereas OSAS is an independent risk factor for hypertension and cardiovascular disease, as well as being strongly associated with obesity and insulin resistance, various treatments have been currently proposed, including surgery, oral appliances, CPAP use, as well as changes in lifestyle, which focus on inclusion of exercise and decreased calorie intake, which promotes the reduction of anthropometric measurements and improvement in AHI and respiratory parameters. It is concluded that OSA and obesity trigger endocrine and metabolic disorders, which can negatively affect the health of the individual. Thus, it can be said that the reduction of body mass is clinically important for obese patients with OSAS and should be a measure of important attention in the treatment of this disease. [ABSTRACT FROM AUTHOR]

Symptoms of sleep-disordered breathing, especially obstructive sleep apnea syndrome (OSAS), are common in asthma patients and have been associated with asthma severity. It is known that asthma symptoms tend to be more severe at night and that asthma-related deaths are most likely to occur during the night or early morning. Nocturnal symptoms occur in 60-74% of asthma patients and are markers of inadequate control of the disease. Various pathophysiological mechanisms are related to the worsening of asthma symptoms, OSAS being one of the most important factors. In patients with asthma, OSAS should be investigated whenever there is inadequate control of symptoms of nocturnal asthma despite the treatment recommended by guidelines having been administered. There is evidence in the literature that the use of continuous positive airway pressure contributes to asthma control in asthma patients with obstructive sleep apnea and uncontrolled asthma.

São poucos os estudos que comparam resultados endoscópicos no paciente acordado com o mesmo paciente sob sono induzido por drogas. OBJETIVOS: O objetivo do presente estudo é comparar os acha dos endoscópicos num mesmo paciente, em dois momentos diferentes: ambulatorial e sob sedação com propofol, por meio da classificação de Fujita. Desenho do estudo: estudo de coorte transversal. MÉTODO: Trinta e quatro pacientes foram submetido ao exame otorrinolaringológico ambulatorial, incluindo nasoendoscopia com manobra de Müller com o paciente acordado e à sonoendoscopia com propofol. A classificação de Fujita foi adotada para comparar os dois exames endoscópicos. Correlacionamos a concordância entre os exames com dados clínicos dos pacientes, como Índice de Massa Corporal, idade e gravidade da síndrome da apneia obstrutiva do sono. RESULTADOS: Não houve concordância nenhuma entre os dois exames endoscópicos, seja para o grupo no geral, seja para cada um dos subgrupos analisados. CONCLUSÃO: Não existe concordância entre os achados endoscópicos com o paciente acordado e os mesmos com o paciente com sono induzido.Only a few studies have compared the outcomes of patients kept awake during endoscopic examination and subjects submitted to drug-induced sleep endoscopy. OBJECTIVE: This study aimed to compare the endoscopic findings of patients submitted to outpatient endoscopy and endoscopic examination with sedation by propofol based on the Fujita Classification. METHOD: This cross-sectional cohort study enrolled 34 patients. The subjects underwent ENT examination, nasal endoscopy with Müller's maneuver, and drug-induced sleep endoscopy with propofol. The Fujita Classification was used to compare the two modes of endoscopic examination. The examinations were correlated to patient clinical data such as BMI, age, and OSAS severity. RESULTS: There was no agreement between the two modes of endoscopic examination, whether for the group in general or for the analyzed subgroups. CONCLUSION: There was no agreement between the endoscopic findings of endoscopic examinations done with the patient awake or in drug-induced sleep.

OBJETIVO: Identificar o papel do broncodilatador no tempo de apneia voluntária máxima em pacientes com distúrbios ventilatórios obstrutivos (DVOs). MÉTODOS: Estudo caso-controle incluindo pacientes com DVOs e grupo controle. Foram realizadas espirometrias antes e após o uso de broncodilatador, assim como testes de apneia respiratória, utilizando-se um microprocessador eletrônico e um pneumotacógrafo como transdutor de fluxo. As curvas de fluxo respiratório foram exibidas em tempo real em um computador portátil, e os tempos de apneia voluntária inspiratória e expiratória máximos (TAVIM e TAVEM, respectivamente) foram determinados a partir do sinal adquirido. RESULTADOS: Um total de 35 pacientes com DVOs e 16 controles foram incluídos no estudo. O TAVIM sem o uso de broncodilatador foi significativamente menor no grupo DVO que no grupo controle (22,27 ± 11,81 s vs. 31,45 ± 15,73; p = 0,025), mas essa diferença não foi significativa após o uso de broncodilatador (24,94 ± 12,89 s vs. 31,67 ± 17,53 s). Os valores de TAVEM foram significativamente menores no grupo DVO que no grupo controle antes (16,88 ± 6,58 s vs. 22,09 ± 7,95 s; p = 0,017) e após o uso de broncodilatador (21,22 ± 9,37 s vs. 28,53 ± 12,46 s; p = 0,024). CONCLUSÕES: Estes resultados fornecem uma evidência adicional da utilidade clínica do teste de apneia na avaliação da função pulmonar e do papel do broncodilatador nesse teste.OBJECTIVE: To identify the role of bronchodilators in the maximal breath-hold time in patients with obstructive lung disease (OLD). METHODS: We conducted a case-control study including patients with OLD and a control group. Spirometric tests were performed prior to and after the use of a bronchodilator, as were breath-hold tests, using an electronic microprocessor and a pneumotachograph as a flow transducer. Respiratory flow curves were displayed in real time on a portable computer. The maximal breath-hold times at end-inspiratory volume and at end-expiratory volume (BHTmaxV EI and BHTmaxV EE, respectively) were determined from the acquired signal. RESULTS: A total of 35 patients with OLD and 16 controls were included. Prior to the use of a bronchodilator, the BHTmaxV EI was significantly lower in the OLD group than in the control group (22.27 ± 11.81 s vs. 31.45 ± 15.73 s; p = 0.025), although there was no significant difference between the two groups in terms of the post-bronchodilator values (24.94 ± 12.89 s vs. 31.67 ± 17.53 s). In contrast, BHTmaxV EE values were significantly lower in the OLD group than in the control group, in the pre- and post-bronchodilator tests (16.88 ± 6.58 s vs. 22.09 ± 7.95 s; p = 0.017; and 21.22 ± 9.37 s vs. 28.53 ± 12.46 s; p = 0.024, respectively). CONCLUSIONS: Our results provide additional evidence of the clinical usefulness of the breath-hold test in the assessment of pulmonary function and add to the existing knowledge regarding the role of the bronchodilator in this test.

OBJETIVO: Investigar a consistência da duração e a reprodutibilidade do padrão dos eventos acústicos relacionados à deglutição de indivíduos sem queixa. MÉTODOS: Oitenta e oito mulheres e 76 homens, entre 6 e 85 anos, com um microfone acoplado ao pescoço e ligado a um computador, realizaram nove deglutições de saliva, e de 5 ml e 10 ml de água. A partir do registro acústico dos sons captados, analisaram-se as durações dos intervalos entre os picos dos dois principais cliques de deglutição (T), da apneia da deglutição (dA), e a relação entre ambos (T/dA). RESULTADOS: Não houve diferenças quanto às durações médias dos tempos entre os picos dos dois cliques da deglutição (T), da apneia da deglutição (dA) e da relação T/dA nas diferentes faixas etárias ou entre os gêneros, com exceção do índice T/dA para as deglutições de 5 ml de água. CONCLUSÃO: Os sons da deglutição apresentam um padrão característico e reprodutível, sendo distinguíveis de ruídos externos e de outros sons produzidos na região cervical, podendo, assim, ser utilizados em métodos de avaliação das disfagias.PURPOSE: To investigate the consistency of duration and reproducibility of the pattern of acoustical events related to the swallowing of individuals without complaints. METHODS: Participants were 88 women and 76 men with ages between 6 and 85 years. With a microphone attached to the neck and connected to a computer, each of them performed nine swallowings of saliva, of 5 ml of water, and of 10 ml of water. Based on the acoustic registration of the sounds recorded, the duration of the interval between the peaks of the two main swallowing clicks (T), of the swallowing apnea (dA), and of the relationship between them (T/dA). RESULTS: No differences were found regarding the mean duration between the peaks of the two swallowing clicks (T), the mean duration of the swallowing apnea (dA), and the relationship T/dA in the different age ranges and between genders, except for the T/dA index for the swallowing of 5 ml of water. There was no correlation between age and the measured parameters. CONCLUSION: The swallowing sounds present a characteristic reproducible pattern, which is distinct both from external noises and from other sounds produced in the cervical region. Therefore, they may be used in dysphagia evaluation methods.

The International Classification of Sleep Disorders lists 90 disorders. Manifestations, such as snoring, are important signs in the diagnosis of the Obstructive Sleep Apnea Syndrome; they are also socially undesirable. OBJECTIVE: The aim of this paper was to present and evaluate a computerized tool that automatically identifies snoring and highlights the importance of establishing the duration of each snoring event in OSA patients. MATERIAL AND METHODS: The low-sampling (200 Hz) electrical signal that indicates snoring was measured during polysomnography. The snoring sound of 31 patients was automatically classified by the software. The Kappa approach was applied to measure agreement between the automatic detection software and a trained observer. Student's T test was applied to evaluate differences in the duration of snoring episodes among simple snorers and OSA snorers. RESULTS: Of a total 43,976 snoring episodes, the software sensitivity was 99. 26%, the specificity was 97. 35%, and Kappa was 0. 96. We found a statistically significant difference (p A classificação internacional de distúrbios do sono enumera aproximadamente 90 distúrbios. Manifestações, como o ronco, são um sinal no diagnóstico da Síndrome da Apneia Obstrutiva, além de ser um incômodo social. OBJETIVO: O objetivo deste artigo é apresentar e avaliar a ferramenta computacional que identifica o ronco automaticamente e destacar a importância da quantificação da duração de cada evento do ronco em pacientes com SAHOS. MATERIAL E MÉTODOS: O sinal elétrico que representa o ronco de baixa amostragem (200 hz) foi captado enquanto os pacientes eram submetidos à polissonografia. O sinal do ronco dos 31 pacientes foi classificado pelo programa computacional automaticamente. Utilizamos o valor de Kappa para avaliar a concordância entre o programa de detecção automática e o observador treinado (teste t-student). Avaliamos a diferença da duração dos episódios de ronco entre simples roncadores e roncadores com SAOS. RESULTADOS: De um total de 43,976 roncos, o programa computacional obteve uma sensibilidade de 99,26%, especificidade de 97,35% e Kappa de 0,96. Foi observada diferença estatística significante (p

OBJETIVO: Determinar a influência da presença de cafeína no sangue de cordão umbilical na ocorrência de apneia. MÉTODOS: Estudo de coorte prospectivo de recém-nascidos pré-termo com peso de nascimento menor que 2.000 g. Os critérios de exclusão foram: mães que receberam opioides; ventilação mecânica durante os primeiros 4 dias de vida; malformações cerebrais e cardíacas maiores; asfixia perinatal; hemorragia peri-intraventricular grave; exsanguineotransfusão antes do quarto dia de vida; e uso de metilxantina antes da extubação. Os recém-nascidos foram divididos em com e sem cafeína detectável no sangue de cordão umbilical, sendo acompanhados nos primeiros 4 dias para verificar ocorrência de apneia. RESULTADOS: Oitenta e sete recém-nascidos com e 40 sem cafeína detectável no sangue de cordão umbilical foram estudados. A mediana da concentração de cafeína dos 87 pacientes com cafeína detectável no sangue de cordão umbilical foi 2,3 µg/mL (0,2-9,4 µg/mL). Não houve associação entre ocorrência de apneia e presença de cafeína no sangue de cordão umbilical. Recém-nascidos com cafeína detectável no cordão umbilical tiveram tendência a apresentar apneia mais tardiamente (66,3±4,14 horas) do que aqueles com níveis indetectáveis (54,2±6,26 horas). CONCLUSÃO: A detecção de níveis de cafeína no sangue de cordão umbilical não diminuiu a ocorrência de apneia da prematuridade, mas teve um efeito limítrofe atrasando sua ocorrência, o que sugere que mesmo um nível baixo de cafeína no sangue de cordão umbilical pode retardar a ocorrência de apneia.OBJECTIVE: To determine the influence of presence of caffeine in umbilical cord blood on apnea occurrence. METHODS: A prospective cohort study with preterm newborns with birth weight lower than 2,000 g was undertaken. Exclusion criteria were: mothers who received opioids; mechanical ventilation during the first 4 days of life; cerebral and major cardiac malformations; perinatal asphyxia; severe periintraventricular hemorrhage; exchange transfusion before the fourth day of life; and those who received methylxantine prior to extubation. Neonates were divided into detectable and undetectable caffeine in umbilical cord blood. Newborns were followed for the first 4 days for occurrence of apnea spells. RESULTS: Eighty-seven newborns with and 40 without detectable caffeine in umbilical cord blood were studied. Median caffeine concentration of the 87 patients with detectable caffeine in umbilical blood was 2.3 µg/mL (0.2-9.4 µg/mL). There was no association between occurrence of apnea spells and presence of caffeine in umbilical cord blood. Neonates with detectable caffeine in umbilical blood had borderline later apnea (66.3±4.14 hours) than those with undetectable levels (54.2±6.26 hours). CONCLUSION: Detected levels of caffeine in umbilical cord blood did not decrease occurrence of apnea of prematurity, but it had a borderline effect delaying its occurrence, suggesting that even a low level of caffeine in umbilical cord blood might delay occurrence of apnea spells.

CONTEXT: Breathing and swallowing coordination, despite the expressive number of study, remain as theme deserving further research. OBJECTIVE: To identify a coordination pattern between swallowing and the natural breathing pause that occur in association with it (swallowing apnea) and also the relevance of the vocal folds closure in this process. METHODS: Sixty-six adults, male and female, including normal health people, post-laryngectomy individuals and patients with digestive complaints without dysphagia were analyzed. The respiratory air flux interruptions produced by wet requested swallows and dry, requested and spontaneous swallows, were registered using thermo and piezoelectric receptors coupled to synectics medical manometry equipment, using Polygram upper 4.21 software. The results were analyzed with the Chi-square (3×2) and (2×2) nonparametric independency test with P = 0.05. RESULTS: Swallowing apnea is a preventive breathing stop that start just before and stay present during all deglutition pharyngeal phase. It is a well coordinated phenomena that occur as pattern in association with low elastic resistance of the lung, on the expiratory final phase until inspiration initial phase. This breathing stoppage it is usually followed by a short expiraton preceding a new breathing cycle. The swallow apnea and vocal folds closure are both independents mechanisms. CONCLUSION: It is possible to suppose that in the subconscious condition, swallowing apnea is integrated under coordination of the same control mechanism that also involves the elastic resistance of the lung.CONTEXTO: Apesar do expressivo número de estudos sobre a coordenação da respiração com a deglutição, o tema permanece aberto à pesquisa. OBJETIVO: Identificar um padrão de coordenação entre a pausa respiratória e a deglutição que ocorre em associação a esta usual apneia (apneia de deglutição) e estabelecer a importância do fechamento das pregas vocais que ocorre em associação a esta apneia. MÉTODOS: Foram estudados 66 adultos de ambos os sexos, incluindo voluntários sadios, indivíduos laringectomizados e pacientes com queixas digestivas sem disfagia. Apneias produzidas em associação com deglutições de liquido a pedido e deglutições a seco, solicitadas e espontâneas, foram registradas a partir de informações captadas por termo receptor e receptor piezelétrico acoplados a equipamento de manometria da Synectics Medical usando o software Polygran upper 4.21. Os resultados foram submetidos a teste de independência não paramétricos qui ao quadrado (3x2) e (2x2), com P = 0.05. RESULTADOS: A apneia de deglutição é uma pausa respiratória preventiva que se inicia imediatamente antes e permanece ativa durante toda a fase faríngea da deglutição. Esta apneia é um bem coordenado fenômeno padrão que ocorre em associação com a baixa resistência elástica dos pulmões, presentes nas fases final da expiração, até a inicial da inspiração. Esta pausa respiratória é usualmente seguida de uma curta expiração que antecede novo ciclo respiratório. A apneia de deglutição e o fechamento das pregas vocais são mecanismos independentes. CONCLUSÕES: É possível supor que em atividade subconsciente, a apneia de deglutição seja integrada sob a coordenação do mesmo mecanismo de controle que também envolve a resistência elástica dos pulmões.

A Síndrome da Apneia Obstrutiva do Sono (SAOS) é definida como episódios recorrentes de obstrução completa ou parcial das vias aéreas superiores que ocorrem durante o sono. O fluxo aéreo pode estar diminuído ou completamente interrompido, a despeito do esforço inspiratório, resultando em episódios intermitentes de hipoxemia, hipercapnia. A presença de SAOS poderá ser um fator de piora da hipoxemia noturna, da doença de base, concorrendo para ocorrência de síndrome torácica aguda. Com o objetivo de revisar dados sobre a fisiopatologia da SAOS em crianças e adolescentes portadores de anemia falciforme, foi realizada busca eletrônica de artigos no Medline e Lilacs nos últimos dez anos, bem como referências cruzadas dos artigos encontrados. Palavras-chaves: "sleep apnea, sickle cell anemia, sickle cell disease, pathophysiology ". Estudos sugerem que a SAOS pode potencializar o quadro clínico, ou seja, as crises álgicas, déficit de estatura, de peso, cognitivo e de inteligência, dessaturação arterial noturna, e acidente vascular cerebral das crianças portadoras de anemia falciforme. Rev. Bras. Hematol. Hemoter.Obstructive Sleep Apnea Syndrome (OSAS) is defined as recurrent episodes of complete or partial obstruction of the upper airway during sleep. The airflow can be reduced or completely stopped despite of inspiratory effort, resulting in intermittent episodes of hypoxemia and hypercapnia. OSAS may be a factor in the worsening of nocturnal hypoxemia, of the underlying disease, leading to acute chest syndrome. The aim of this work was to review data on the pathophysiology of OSAS in children and adolescents with sickle cell anemia. We revisited articles published over the last ten years linked to the Medline and Lilacs databases, as well as cross-referencing using these articles. The following keywords were used: sleep apnea, obstructive sleep apnea, sickle cell anemia, sickle cell disease. Studies suggest that OSAS may increase clinical complications, such as painful crises, delayed growth, cognitive and intelligence disorders, nocturnal arterial desaturation and strokes in children with sickle cell anemia. Studies suggest that OSAS may increase the clinical complications of children with sickle cell anemia. Rev. Bras. Hematol. Hemoter.

BACKGROUND: Attention deficit may be related to sleep disorders in Chiari malformation type II (CMII). Our aim is identify sleep disorders and their specific contribution in attention deficit. METHOD: We selected 24 patients with CM II and 24 without CM II. DSM-IV criteria and a neuropsychological analysis were applied in all. All patients underwent full night polysomnography. RESULTS: 14 CM II patients presented sleep apnea syndrome, REM sleep behavior disorder and periodic limb movement in sleep; six patients without CM II presented sleep apnea syndrome. Among these patients, 12 (six with CM II and six without CM II) presented attention deficit related to the sleep disorders. CONCLUSION: Sleep disorders may impair cognitive functions, as attention, and contribute to poor quality of learning also in patients with CM II.INTRODUÇÃO: Déficits de atenção podem estar relacionados a distúrbios do sono em indivíduos com malformação de Chiari tipo II (CM II). Nosso objetivo é identificar distúrbios do sono e sua contribuição para a ocorrência de déficit de atenção. MÉTODO: Foram selecionados 24 pacientes com CM II e 24 sem CM II. Todos foram submetidos à avaliação neuropsicológica, aos critérios do DSM-IV e a polissonografia. RESULTADOS: 14 pacientes com CM II apresentaram síndrome da apnéia do sono, distúrbio do comportamento da fase do sono REM e movimentos periódicos dos membros em sono; seis pacientes sem CM II apresentaram síndrome da apnéia do sono. Entre estes pacientes, 12 (seis com CM II e seis sem CM II) apresentaram déficit de atenção relacionado a distúrbios do sono. CONCLUSÃO: Distúrbios do sono podem prejudicar funções cognitivas, como a atenção, contribuindo para a piora da qualidade de aprendizado também em pacientes com CM II.

CONTEXT: Sleep has an important function in the physical and emotional development of children. Some studies suggest an association between impulsivity and sleep disorders. However, little is known about this association in schoolchildren aged 8 to 10 years. METHOD: We studied 1180 children, 547 with sleep disorders (SD) and 633 without SD (control group), classified with SD questionnaires. Within the SD group, 53 children with sleep-related respiratory disorders (SRRD) and 521 children with non-respiratory sleep disorders (NRSD) were analyzed. We acessed emotional indicators of impulsivity with Bender test. RESULTS: More SD children presented impulsivity than control group (pCONTEXTO: O sono tem função importante no desenvolvimento físico e emocional das crianças. Alguns estudos sugerem a associação de impulsividade e distúrbios do sono, sendo pouco conhecida esta associação em escolares na faixa etária de 8 a 10 anos. MÉTODO: Estudamos 1180 crianças, 547 com distúrbio do sono (DS) e 633 normais (grupo controle), classificadas através de questionários sobre distúrbios do sono. Dentro do grupo DS, analisamos separadamente as crianças com distúrbio respiratório relacionado ao sono (DRRS) e com distúrbios não respiratórios do sono (DNRS). Aplicamos o Teste Gestáltico de Bender (TB) para detectar os indicadores emocionais de impulsividade. RESULTADOS: Maior número de crianças com DS apresentaram impulsividade em relação às crianças do grupo controle (p

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We report a case showing the association of Moebius syndrome, the use of misoprostol during pregnancy and the development of central congenital alveolar hypoventilation. Pathophysiological aspects of these three diseases are discussed and also the unfavorable prognosis of this association.Descrevemos o caso de um paciente com Síndrome de Moebius associada ao uso de misoprostol durante a gestação. A criança necessitou de suporte ventilatório desde o primeiro dia de vida e evoluiu com quadro de hipoventilação alveolar central congênita, persistindo dependente de ventilação mecânica. São discutidos aspectos fisiopatológicos que poderiam justificar a comorbidade destes três eventos, assim como o prognóstico reservado desta associação.

A hipótese de que a apnéia pudesse ser o evento final da síndrome da morte súbita da infância (SMSI) deu origem a vários estudos avaliando as características deste evento do ponto de vista polissonográfico. Foi sugerido que a atividade fásica do sono REM estaria associada a ativação dos neurônios respiratórios prevenindo a ocorrência de apnéias prolongadas e protegendo os lactentes de evoluírem para SMSI. Em estudo prévio retrospectivo com recém-nascidos não confirmamos estes achados mas muitos destes bebês apresentavam comprometimento neurológico severo. O objetivo do presente estudo é verificar a relação existente entre períodos de atividade fásica do sono REM (movimentos oculares rápidos e movimentos de sucção) e apnéia. Estudamos do ponto de vista clínico c polissonográfico 86 recém-nascidos c lactentes encaminhados para avaliação por terem apresentado apnéia ou episódios com aparente risco de vida durante o sono. Dividimos os pacientes em 3 grupos: recém-nascidos (idade concepcional inferior a 44 semanas, n=31), lactentes com 1 -6 meses (n=48) e lactentes com >6m6When the apnea hypothesis turned to be an explanation for sudden infant death syndrome (SIDS) many authors tried to find if near-miss or apparent life-threatening events (ALTE) could be markers of SIDS. It was suggested that phasic REM activity is associated with increased respiratory neuron activity and prevents prolonged apnea in near-miss SIDS. In a previous retrospective study with newborns we did not confirm these results, nevertheless we had several babies with serious neurological disturbances. The aim of this study was to verify the relationship of phasic activity (rapid eyes movement and sucking bursts) with both apneic and non-apneic epochs during REM sleep. We studied 86 children refered for evaluation because they presented an ALTE during sleep or apneas. The subjects were divided in three groups by age (newborns, n=31; 1 -6 months, n= 48; and >6< 12 months, n=7). They were all submitted to a clinical and neurological evaluation in order to detect possible etiological factors to the apneic episode. The po.lysomnograms (PS) consisted of EEG, submental EMG, electro-oculogram and cardiorespiratory monitoring. The records were made between 11 am and 15 pm for 2 or 3 hours. The electrodes were disposed in the 10-20 system. During one five-minutes epoch of REM sleep we verified the incidence of phasic activity (rapid eyes movement or sucking bursts) time locked to apneic episodes and compared with a similar duration non-apneic epoch. To evaluate the relationship of phasic activity with apneic and non-apneic epochs we compared the incidence of rapid eyes movements and sucking bursts in each group. Our results showed that phasic activity of REM sleep (sucking bursts) seems to be more frequent in newborns in non-apneic epochs (p < 0.05). Between 1-6 months the number of rapid eyes movements were more frequent in non-apneic epochs (p=0.00l). In conclusion our findings suggest that phasic activity of REM sleep seems to be more evident in nonapneic epochs during the first six months of life. Although central apneas may have their origin in an intrinsic disturb of the respiratory control center they may be influenced by the phasic activity of REM sleep. The rapid eyes movements and sucking bursts may have a protection effect against apneas at least in the first 6 months of life, which is the predominant period for SIDS. We suggest that the excitatory driving related to generation of phasic activity in REM sleep may block or atenuate tonic inhibition of respiratory motoneuron and avoid apnea. It is still open for discussion the possible relation between failure of this protective mechanism and SIDS.

The obstructive sleep apnea syndrome (OSAS) are recurrent episodes of partial or complete blockage of the upper airway. This obstruction is usually followed by a reduction in oxyhemoglobin saturation. The amount of air flow during breathing is characterized in two ways: apnea and hypopnea. There are several types of diagnosis, including computed tomography (CT) and a polysomnography that is characterized as a "gold standard" for diagnosis. The computed tomography is a method that allows to evaluate all hard tissues and soft tissues of the head and neck. When applied in the evaluation of the upper airway, the CT provides more anatomical details, if there is some abnormality which determines the OSAS, the computed tomography (CT) is able to identify these changes. Polysomnography is the simultaneous recording of the stages and sleep continuity, respiratory effort, oxygen saturation, body position, electrocardiogram, pulse oximetry and body movements. The exam is performed overnight in the laboratory, and monitored the whole night. The treatments can be invasive and non-invasive, non-invasive are positive airway pressure (PAP) devices, oral devices, nasal dilators; invasive treatments are surgeries involving the maxillaries and tonsillectomy. Treatment depends on the intensity and origin of OSAS. [ABSTRACT FROM AUTHOR]

Purpose: to evaluate some polysomnographic parameters of patients that were referred to use mandibular protusion device (MPD). Methods: we studied, retrospectively, data from medical records with items that made up polysomnography of 124 patients aged between 25-77 years, that were not having any treatment for OSAHS. The study was approved by the Ethics Committee of origin institution (CAE number 0378.0.133.000-10). Results: 46.8% of respondents had mild apnea, snoring and most had poor sleep efficiency. Almost all of these patients had OSAHS. The lower oxygen saturation during the test ranged from 60% to 97%, with more than four fifths of the sample rates below 90%. Conclusion: there was no significant relationship between rates of apnea and the levels of oxyhemoglobin saturation. Sleep efficiency was directly related to the severity of OSA, with statistical evidence; oximetry can be a valuable tool for the diagnosis of OSA, but cannot be sole source to refer to the severity of the syndrome, REM sleep was poor in most investigated, and this was significantly related to sleep efficiency. [ABSTRACT FROM AUTHOR]

The aim of this study was to characterize the structure of solo and duet-based synchronized swimming routines. This was done using a specific nomothetic multidimensional observational design. The ad hoc observational instrument was validated by 12 specialists. The data was recorded using LINCE software, and observational reliability was determined by calculating the degree of intra-observer and inter-observer agreement. The participants were 18 female swimmers (including six Olympic medallists), and 39 routines were analysed: technical solos (n = 9), free solos (n = 11), technical duets (n = 10) and free duets (n = 9). The swimmers spent 61.6 ± 6.4 % of the competition time with their faces immersed in the water, with maximum apnea of 21.1 ± 4.0 s. The inverted-vertical position was the most widely taken in routines (43.2 ± 5.3 %), with the phase of deep immersion in that position being the most commonly reproduced (35.3 ± 5.0 %). In conclusion: 1) the observational instrument is a valid tool for analysing the structure of routines in synchronized swimming; and 2) there are significant differences in the structure of routines as regards their total duration, episodes of apnea, and the degree of immersion in different body positions. [ABSTRACT FROM AUTHOR]