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ellison e., lapuerta p. and martin s. e. (1998) Cytopathology 9, 222–229 Fine needle aspiration (FNA) in HIV+ patients: results from a series of 655 aspirates There are many selected small series or case reports of FNAs in patients with HIV infection, but large series are rare and the epidemic's characteristics have evolved over time. The current study, from a large public hospital in the USA, included women as well as men, hetero- and homosexuals, in-patients and out-patients, and deep radiologically guided aspirates as well as superficial masses. Of 655 FNAs, reactive or benign changes were present in 37%, confirmed or suspected malignancy in 13%, speciwc infection with stainable organisms in 14%, and inflammation in 16%. Twenty percent of cases were inadequate for diagnosis. Most of the identiwable infections were associated with Mycobacterium tuberculosis, with fewer atypical mycobacteria, fungi and other bacteria. Clinically signiwcant diagnoses were correlated with deep aspirate location and lesion size > 2 cm, conwrming other studies which also identiwed tenderness and recent enlargement as important indicators. The liberal use of FNA in our HIV+ population has greatly reduced the necessity for surgical nodal resection, reassured clinicians in continuing observation of reactive lymphadenopathy, and allowed immediate therapy for speciwc infection, cyst or malignancy. [ABSTRACT FROM AUTHOR]