Search

Your search keyword '"Apel K"' showing total 367 results
Start Over Author "Apel K"

Refine your results

more »

more »

more »

more »
367 results on '"Apel K"'

5. Rapid, complete and sustained tumour response to the TRK inhibitor larotrectinib in an infant with recurrent, chemotherapy-refractory infantile fibrosarcoma carrying the characteristic ETV6-NTRK3 gene fusion

Author

Bielack, S.S., Cox, M.C., Nathrath, M., Apel, K., Blattmann, C., Holl, T., Jenewein, R., Klenk, U., Klothaki, P., Müller-Abt, P., Ortega-Lawerenz, S., Reynolds, M., Scheer, M., Simon-Klingenstein, K., Stegmaier, S., Tupper, R., Vokuhl, C., and von Kalle, T.

Published
2019
Full Text
View/download PDF

11. Drug-induced liver injury-significance of pathology

Author

Apel, K., Puetz, K., Tolkach, Y., Canbay, A., Drebber, U., Apel, K., Puetz, K., Tolkach, Y., Canbay, A., and Drebber, U.

Abstract

Many different medical agents, herbal products, and dietary supplements can induce drug-induced liver injury (DILI) as a clinically relevant complication. DILI, which is direct toxic or idiosyncratic, can have a broad spectrum of clinical appearances from elevation of liver enzymes to acute liver failure. DILI is categorized clinically according to the pattern of serum parameters or pathologically according to the pattern of histomorphology. Histopathological patterns can be described as hepatitic, granulomatous, cholestatic, ductopenic, fibrotic, steatotic, steatohepatitic, and vascular. Correlation to the corresponding drug can be carried out with the corresponding databases (US National Library of Medicine, Liver Tox;). Liver biopsy, in contrast to a clinical/serological diagnostic, has the advantage of an exact resolution with evidence of pathophysiology, activity, regeneration, chronification, and prognosis. Co-occurrence of underlying liver disease can be excluded or confirmed. Histological patterns of DILI are described and illustrated. A diagnostic algorithm for the interpretation of liver biopsies is provided.

Published
2020

20. The German PID-net registry

Author

El-Helou, S. M., Biegner, A. K., Bode, S., Ehl, S., Heeg, M., Ritterbusch, H., Rusch, S., Schmitt, R., Warnatz, K., Baerlecken, N. T., Baumann, U., Beider, R., Ernst, D., Gerschmann, S., Klemann, C., Mielke, G., Schmidt, R. E., Schuermann, G., Viemann, D., Albert, M., Eichinger, A., Eisl, E., Hauck, F., Klein, C., Sollinger, F., von Bernuth, H., Hanitsch, L., Krueger, R., Scheibenbogen, C., Avila, A., Borte, M., Borte, S., Fasshauer, M., Hauenherm, A., Kellner, N., Mueller, H., Uelzen, A., Bader, P., Bakhtiar, S., Hess, U., Lee, J. Y., Schubert, R., Voss, S., Zielen, S., Bienemann, K., Lankisch, P., Laws, H. J., Neubert, J., Dueckers, G., Lamers, B., Langemeyer, V., Niehues, T., Hoenig, M., Schulz, A., Schwarz, K., Steinmann, S., Graf, D., Haase, G., Liese, J. G., Morbach, H., Schwaneck, E., Tony, H. P., Foell, D., Hellige, A., Masjosthusmann, K., Mohr, M., Wittkowski, H., Fischer, J. C., Hedrich, C. M., Roesen-Wolff, A., Roesler, J., Behrends, U., Rieber, N., Schauer, U., Boesecke, C., Dilloo, D., Engelhardt, A., Huelsmann, B., Rockstroh, J., Scholtes, C., Schoenberger, S., Wasmuth, J. C., Handgretinger, R., Henes, J., Holzer, U., Kanz, L., Ankermann, T., von Bismarck, P., Schreiber, S., Zeuner, R., Huppertz, H. I., Kaiser-Labusch, P., Greil, J., Jakoby, D., Kulozik, A. E., Graf, N., Heine, S., Garwer, B., Kobbe, R., Lehmberg, K., Mueller, I., Herrmann, F., Horneff, G., Klein, A., Peitz, J., Schmidt, N., Apel, K., Bielack, S., Gross-Wieltsch, U., Deutz, P., Lassay, L., Kamitz, D., Stienen, A., Tenbrock, K., Wagner, N., Classen, C. F., Weiss, M., Bernbeck, B., Brummel, B., Lara-Villacanas, E., Muenstermann, E., Schneider, D., Tietsch, N., Westkemper, M., Naumann-Bartsch, N., Metzler, M., Sobik, B., Kuehnle, I., Kullmann, S., Kramm, C., Girschick, H., Elbe, S., Specker, C., Vinnemeier-Laubenthal, L., Haenicke, H., Schulz, C., Schweigerer, L., Mueller, T. G., Kindle, G., Grimbacher, B., El-Helou, S. M., Biegner, A. K., Bode, S., Ehl, S., Heeg, M., Ritterbusch, H., Rusch, S., Schmitt, R., Warnatz, K., Baerlecken, N. T., Baumann, U., Beider, R., Ernst, D., Gerschmann, S., Klemann, C., Mielke, G., Schmidt, R. E., Schuermann, G., Viemann, D., Albert, M., Eichinger, A., Eisl, E., Hauck, F., Klein, C., Sollinger, F., von Bernuth, H., Hanitsch, L., Krueger, R., Scheibenbogen, C., Avila, A., Borte, M., Borte, S., Fasshauer, M., Hauenherm, A., Kellner, N., Mueller, H., Uelzen, A., Bader, P., Bakhtiar, S., Hess, U., Lee, J. Y., Schubert, R., Voss, S., Zielen, S., Bienemann, K., Lankisch, P., Laws, H. J., Neubert, J., Dueckers, G., Lamers, B., Langemeyer, V., Niehues, T., Hoenig, M., Schulz, A., Schwarz, K., Steinmann, S., Graf, D., Haase, G., Liese, J. G., Morbach, H., Schwaneck, E., Tony, H. P., Foell, D., Hellige, A., Masjosthusmann, K., Mohr, M., Wittkowski, H., Fischer, J. C., Hedrich, C. M., Roesen-Wolff, A., Roesler, J., Behrends, U., Rieber, N., Schauer, U., Boesecke, C., Dilloo, D., Engelhardt, A., Huelsmann, B., Rockstroh, J., Scholtes, C., Schoenberger, S., Wasmuth, J. C., Handgretinger, R., Henes, J., Holzer, U., Kanz, L., Ankermann, T., von Bismarck, P., Schreiber, S., Zeuner, R., Huppertz, H. I., Kaiser-Labusch, P., Greil, J., Jakoby, D., Kulozik, A. E., Graf, N., Heine, S., Garwer, B., Kobbe, R., Lehmberg, K., Mueller, I., Herrmann, F., Horneff, G., Klein, A., Peitz, J., Schmidt, N., Apel, K., Bielack, S., Gross-Wieltsch, U., Deutz, P., Lassay, L., Kamitz, D., Stienen, A., Tenbrock, K., Wagner, N., Classen, C. F., Weiss, M., Bernbeck, B., Brummel, B., Lara-Villacanas, E., Muenstermann, E., Schneider, D., Tietsch, N., Westkemper, M., Naumann-Bartsch, N., Metzler, M., Sobik, B., Kuehnle, I., Kullmann, S., Kramm, C., Girschick, H., Elbe, S., Specker, C., Vinnemeier-Laubenthal, L., Haenicke, H., Schulz, C., Schweigerer, L., Mueller, T. G., Kindle, G., and Grimbacher, B.

Published
2017

21. The European internet-based patient and research database for primary immunodeficiencies: update 2011

Author

Gathmann B., Binder N., Ehl S., Kindle G., Mahlaoui N., Devergnes N., Brosselin P., Sanal O., Yegin O., Kutukculer N., Kilic S. S., Barlan I. B., Reisly I., Caracseghi F., Santos J. L., Llobet P., Carbone J., Granado L. I. G., Sanchez Ramon S., Tricas L., Matamoros N., Exley A., Kumaratne D., Alwood Z., Grimbacher B., Longhurst H., Knerr V., Bangs C., Boardman B., Tierney P., Chapel H., Notarangelo L. D., Plebani A., PIGNATA, CLAUDIO, Nickel R., Schauer U., Spath B., Caiser P., Roisler J., Bieneman K., Line R., Schubert R., El Helou S., Ritterbusch H., Goldacker S., Duckers G., Fabhauer M., Borte M., Notheis G., Belohradsky B. H., Sollinger F., Classen C. F., Apel K., Steinmann S., Muglich C., Szaflarska A., Bernatowska E., Heropolitansca E., Kuijpers T. W., van Beem R., Galal N. M., Reda S., Farber C. L., Meyts I., Velbri S., Kanariou M., Farmaki E., Papadopoulou Alataki E., Trachana M., Richter D., Blaziene A., Seidel M., Marques L., Feighery C., Cucuruz M., Konoplyannikova J., Paschenko O., Shcherbina A., Berglof A., Jardefors H., Wargstrom P., Brodszki N., Cantoni N., Dupenthaler A., Fahrni G., Hoernes M., Sahbacher U., Pasic S., Ciznar P., Jeverica A. K., Litzman J., Hlavackova E., Savchak I., Farkas H., Marodi L., Gathmann, B., Binder, N., Ehl, S., Kindle, G., Mahlaoui, N., Devergnes, N., Brosselin, P., Sanal, O., Yegin, O., Kutukculer, N., Kilic, S. S., Barlan, I. B., Reisly, I., Caracseghi, F., Santos, J. L., Llobet, P., Carbone, J., Granado, L. I. G., Sanchez Ramon, S., Tricas, L., Matamoros, N., Exley, A., Kumaratne, D., Alwood, Z., Grimbacher, B., Longhurst, H., Knerr, V., Bangs, C., Boardman, B., Tierney, P., Chapel, H., Notarangelo, L. D., Plebani, A., Pignata, Claudio, Nickel, R., Schauer, U., Spath, B., Caiser, P., Roisler, J., Bieneman, K., Line, R., Schubert, R., El Helou, S., Ritterbusch, H., Goldacker, S., Duckers, G., Fabhauer, M., Borte, M., Notheis, G., Belohradsky, B. H., Sollinger, F., Classen, C. F., Apel, K., Steinmann, S., Muglich, C., Szaflarska, A., Bernatowska, E., Heropolitansca, E., Kuijpers, T. W., van Beem, R., Galal, N. M., Reda, S., Farber, C. L., Meyts, I., Velbri, S., Kanariou, M., Farmaki, E., Papadopoulou Alataki, E., Trachana, M., Richter, D., Blaziene, A., Seidel, M., Marques, L., Feighery, C., Cucuruz, M., Konoplyannikova, J., Paschenko, O., Shcherbina, A., Berglof, A., Jardefors, H., Wargstrom, P., Brodszki, N., Cantoni, N., Dupenthaler, A., Fahrni, G., Hoernes, M., Sahbacher, U., Pasic, S., Ciznar, P., Jeverica, A. K., Litzman, J., Hlavackova, E., Savchak, I., Farkas, H., and Marodi, L.

Abstract

In order to build a common data pool and estimate the disease burden of primary immunodeficiencies (PID) in Europe, the European Society for Immunodeficiencies (ESID) has developed an internet-based database for clinical and research data on patients with PID. This database is a platform for epidemiological analyses as well as the development of new diagnostic and therapeutic strategies and the identification of novel disease-associated genes. Since its start in 2004, 13,708 patients from 41 countries have been documented in the ESID database. Common variable immunodeficiency (CVID) represents the most common entity with 2880 patients or 21% of all entries, followed by selective immunoglobulin A (sIgA) deficiency (1424 patients, 10·4%). The total documented prevalence of PID is highest in France, with five patients per 100,000 inhabitants. The highest documented prevalence for a single disease is 1·3 per 100,000 inhabitants for sIgA deficiency in Hungary. The highest reported incidence of PID per 100,000 live births was 16·2 for the period 1999-2002 in France. The highest reported incidence rate for a single disease was 6·7 for sIgA deficiency in Spain for the period 1999-2002. The genetic cause was known in 36·2% of all registered patients. Consanguinity was reported in 8·8%, and 18·5% of patients were reported to be familial cases; 27·9% of patients were diagnosed after the age of 16. We did not observe a significant decrease in the diagnostic delay for most diseases between 1987 and 2010. The most frequently reported long-term medication is immunoglobulin replacement.

Published
2012

24. Third symposium onAcetabularia

Author

Alexeev, A. B., Stvolinsky, S. L., Tikhomirova, L. A., Yazykov, A. A., Zubarev, T. N., Apel, K., Bachmann, Peter, Zetsche, Klaus, Bannwarth, Horst, Berger, Sigrid, Boege, Ulrike, Boege, Frank, Gradmann, D., Bokeloh, G., Bonotto, S., Lurquin, P., Baeyens, W., Charles, P., Hoursiangou-Neubrun, D., Mazza, A., Tramontano, G., Felluga, B., BrÄndle, Ernst P. O., Kötter, Renate, Dazy, A. C., Borghi, H., Gauchery, J., Puiseux-Dao, S., Dubacq, J. P., Franke, W. W., Berger, S., Scheer, U., Trendelenburg, M. F., GlÄsel, Rainer M., Herth, Werner, Guillo, M., Karakashian, Marlene W., Kloppstech, Klaus, Koop, Hans-Ulrich, Legros, F., Dumon, I., Hanson, B., Jeanmart, J., Conard, V., Novak, B., Pai, H. S., Dehm, D., Schweiger, M., Rahmsdorf, H. J., Ponta, H., Hirsch-Kauffmann, M., Schweiger, H. G., Schweiger, Hans-Georg, Kretschmer, Horst, Spring, H., Falk, H., Vanden Driessche, T., Delegher-Langohr, V., Hayet, Michèle, Moens, W., Kram, R., Woodcock, C. L. F., Zetsche, K., and Wutz, M.

Published
1975
Full Text
View/download PDF

25. Abstract from the international workshop on morphogenesis inAcetabularia

Author

Bannwarth, H., Ikehara, N., Schweiger, H. -G., Bartkiewicz, Agata, Wilczok, T., Berger, S., Bodard, F., Nuyts, G., Bonotto, S., Carraro, G., Lüttke, A., Bossus, A., Kirchmann, R., Bratz, Sibylla, Richter, G., Broda, H., Dazy, A. C., Puiseux-Dao, S., Durand, M., Santa-Maria, A., de Groot, E., Vanden Driessche, Thérèse, Guisset, J. -L., Harrison, L. G., Snell, Janet, Verdi, R., Zeiss, G. D., Green, Beverly R., Lacalli, Th. C., Hoursiangou-Neubrun, D., Hrib, J., Kof, E. M., Kefeli, V. I., Lenski, M., Werz, G., Lüttke, Angela, Mundt, H., Christiansen, Petra, Paques, M., Brouers, M., Paradies, H. H., Borghi, H., Brun, C., Provost, J. M., Durrand, M., Moini-Zanjani, T., Schmid, R., Koop, H. -U., Wolff, D., Shihira-Ishikawa, Ikuko, Yano, Dirce Mithico Yamaoka, Shoeman, R., Wasilewska, L., Viro, M., Kloppstech, K., Apel, K., Zimmer, B., and Zetsche, K.

Published
1981
Full Text
View/download PDF

27. Fourth symposium onAcetabularia

Author

Apel, K., Bonotto, S., Dujardin, E., Puiseux-Dao, S., Sironval, C., Franke, W. W., Kartenbeck, J., Spring, H., Gibor, A., Green, B. R., Kloppstech, K., Koop, H. U., Mazza, A., Niemeyer, R., Hoursiangou-Neubrun, D., Dubacq, J. P., Oblin, S., Borghi, H., Dazy, A. C., Richter, G., Schweiger, H. G., Karakashian, M., Krohne, G., Trendelenburg, M. F., and Scheer, U.

Published
1977
Full Text
View/download PDF

33. Inleiding

Author

von Schomberg, R. and Apel, K.-O.

Published
1996

Catalog

Books, media, physical & digital resources
See catalog results