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2 results on '"ApaI (rs7975232)"'

1. Relationship between Vitamin D receptor gene polymorphism and renal cell carcinoma susceptibility.

Author

Lin, Zhi-Jun, Zhang, Xia-Lan, Yang, Zhen-Sheng, She, Xiao-Yu, Xie, Yi, and Xie, Wei-Ji

Subjects
*PHYSIOLOGICAL effects of vitamin D, *GENETIC polymorphisms, *RENAL cell carcinoma, *META-analysis, *CAUCASIAN race, *ALLELES, *ASIANS, *CELL receptors, *COMPARATIVE studies, *DISEASE susceptibility, *GENETIC techniques, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *EVALUATION research, *ODDS ratio, *GENOTYPES
Abstract

Aim of Study: Results on the association of Vitamin D receptor (VDR) gene polymorphism with renal cell carcinoma (RCC) susceptibility from the present reports are still debating. This meta-analysis was conducted to assess the association of VDR ApaI (rs7975232), BsmI (rs1544410), TaqI (rs731236), and Fok1 (rs2228570) gene polymorphisms with RCC risk.Materials and Methods: The association studies were recruited from PubMed on May 1, 2016, and eligible reports were extracted and data were synthesized using meta-analysis method.Result: Six investigations were included into this meta-analysis for the relationship between VDR gene polymorphism and RCC susceptibility. In this meta-analysis, the ApaI A allele, AA genotype, aa genotype, and Fok1 FF genotype were associated with RCC susceptibility in Asians. However, VDR BsmI and TaqI gene polymorphisms were not associated with the RCC risk in Asians, Caucasians, and overall populations. Furthermore, Fok1 gene polymorphism was not associated with the RCC risk in Caucasians and overall populations.Conclusion: ApaI gene polymorphism and Fok1 FF genotype were associated with RCC susceptibility in Asians. [ABSTRACT FROM AUTHOR]

Published
2018
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2. Relationship between Vitamin D receptor gene polymorphism and renal cell carcinoma susceptibility

Author

Xialan Zhang, Zhen-Sheng Yang, Weiji Xie, Zhijun Lin, Yi Xie, and Xiao-Yu She

Subjects
0301 basic medicine, Oncology, medicine.medical_specialty, renal cell carcinoma, TaqI, Genotype, gene polymorphism, ApaI (rs7975232), Single-nucleotide polymorphism, urologic and male genital diseases, Calcitriol receptor, lcsh:RC254-282, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Asian People, Internal medicine, Vitamin D and neurology, Odds Ratio, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Genetic Predisposition to Disease, Allele, Carcinoma, Renal Cell, Alleles, Genetic Association Studies, Genetic association, business.industry, General Medicine, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, female genital diseases and pregnancy complications, meta-analysis, 030104 developmental biology, chemistry, Vitamin D receptor, 030220 oncology & carcinogenesis, Receptors, Calcitriol, Gene polymorphism, Fok1 (rs2228570), business, BsmI (rs1544410), TaqI (rs731236), Polymorphism, Restriction Fragment Length
Abstract

Aim of Study: Results on the association of Vitamin D receptor (VDR) gene polymorphism with renal cell carcinoma (RCC) susceptibility from the present reports are still debating. This meta-analysis was conducted to assess the association of VDR ApaI (rs7975232), BsmI (rs1544410), TaqI (rs731236), and Fok1 (rs2228570) gene polymorphisms with RCC risk. Materials and Methods: The association studies were recruited from PubMed on May 1, 2016, and eligible reports were extracted and data were synthesized using meta-analysis method. Result: Six investigations were included into this meta-analysis for the relationship between VDR gene polymorphism and RCC susceptibility. In this meta-analysis, the ApaI A allele, AA genotype, aa genotype, and Fok1 FF genotype were associated with RCC susceptibility in Asians. However, VDR BsmI and TaqI gene polymorphisms were not associated with the RCC risk in Asians, Caucasians, and overall populations. Furthermore, Fok1 gene polymorphism was not associated with the RCC risk in Caucasians and overall populations. Conclusion: ApaI gene polymorphism and Fok1 FF genotype were associated with RCC susceptibility in Asians.

Published
2018

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